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https://www.readbyqxmd.com/read/29755792/sofosbuvir-plus-daclatasvir-in-treatment-of-chronic-hepatitis-c-genotype-4-infection-in-a-cohort-of-egyptian-patients-an-experiment-the-size-of-egyptian-village
#1
Ossama Ashraf Ahmed, Eslam Safwat, Mohamed Omar Khalifa, Ahmed I Elshafie, Mohamed Hassan Ahmed Fouad, Mohamed Magdy Salama, Gina Gamal Naguib, Mohamed Mahmoud Eltabbakh, Ahmed Fouad Sherief, Sherief Abd-Elsalam
Background and Aims: As indicated by the World Health Organization (WHO), Egypt is positioned as the country with the world's highest prevalence of Hepatitis C virus (HCV). HCV is transmitted through unexamined blood transfusions, different employments of syringes, and poor cleansing, as per the WHO. Our study aimed at screening and management of chronic hepatitis C genotype 4 infected patients in Bardeen village, Sharkeya Governorate, Egypt, with Sofosbuvir plus Daclatasvir, as well as estimating the safety and efficacy of that regimen...
2018: International Journal of Hepatology
https://www.readbyqxmd.com/read/29747397/field-efficacy-of-an-attenuated-infectious-bronchitis-variant-2-virus-vaccine-in-commercial-broiler-chickens
#2
Mohamed A Elhady, Ahmed Ali, Walid H Kilany, Wael K Elfeil, Hytham Ibrahim, Ahmed Nabil, Ahmed Samir, Magdy El Sayed
Egyptian poultry suffer from frequent respiratory disease outbreaks associated with Infectious Bronchitis Virus (IBV) variant 2 strains (Egy/VarII). Different vaccination programs using imported vaccines have failed to protect the flocks from field challenge. Recent studies confirmed a successful protection using homologous strains as live attenuated vaccines. In this study, a newly developed live attenuated IB-VAR2 vaccine representing the GI-23 Middle East IBV lineage was evaluated in day-old commercial broilers in an IBV-endemic area...
May 9, 2018: Veterinary Sciences
https://www.readbyqxmd.com/read/29723110/polyamidoamine-pamam-dendrimers-as-potential-release-modulators-and-oral-bioavailability-enhancers-of-vardenafil-hydrochloride
#3
Mai Ahmed Tawfik, Mina Ibrahim Tadros, Magdy Ibrahim Mohamed
Vardenafil hydrochloride (VAR) is an erectile dysfunction treating drug. VAR has a short elimination half-life (4-5 h) and suffers low oral bioavailability (15%). This work aimed to explore the dual potential of VAR-dendrimer complexes as drug release modulators and oral bioavailability enhancers. VAR-dendrimer complexes were prepared by solvent evaporation technique using four dendrimer generations (G4.5, G5, G5.5 and G6) at three concentrations (190 nM, 380 nM and 950 nM). The systems were evaluated for intermolecular interactions, particle size, zeta potential, drug entrapment efficiency percentages (EE%), and drug released percentages after 2 hours (Q2h ) and 24 hours (Q24h )...
May 3, 2018: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29686365/multifunctional-activities-of-erf109-as-affected-by-salt-stress-in-arabidopsis
#4
Ahmed Bahieldin, Ahmed Atef, Sherif Edris, Nour O Gadalla, Ahmed M Ramadan, Sabah M Hassan, Sanaa G Al Attas, Magdy A Al-Kordy, Abdulrahman S M Al-Hajar, Jamal S M Sabir, Mahmoud E Nasr, Gamal H Osman, Fotouh M El-Domyati
Transcriptomic analysis was conducted in leaves of Arabidopsis T-DNA insertion ERF109-knocked out (KO) mutant or plants overexpressing (OE) the gene to detect its role in driving expression of programmed cell death- (PCD-) or growth-related genes under high salt (200 mM NaCl) stress. The analysis yielded ~22-24 million reads, of which 90% mapped to the Arabidopsis reference nuclear genome. Hierarchical cluster analysis of gene expression and principal component analysis (PCA) successfully separated transcriptomes of the two stress time points...
April 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29681097/philtrum-length-and-intercommissural-distance-measurements-at-mixed-dentition-period
#5
Mostafa Mostafa, Nehal Hassib, Inas Sayed, Amany Neamat, Magda Ramzy, Tarek El-Badry, Hisham ElGabry, Haidy Salem, Nada Omar, Amira Ismail, Yousra Ibrahim, Amr Shebaita, Ahmed Allam, Magdy Mostafa
Anthropometric measurements of the lip and mouth are of great importance in clinical dysmorphology as well as reconstructive plastic surgery. In this study, the philtrum length (PhL) and intercommissural distance (ICmD) nomograms for Egyptian children in the mixed dentition period were established. A group of 1,338 Egyptian students in primary schools (735 boys and 603 girls) were included in the study. The students were at mixed dentition period and their ages ranged from 7 to 12 years. Anthropometric norms of PhL and ICmD were developed with significant sex difference in certain groups...
May 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29623600/significance-of-glypican-3-in-early-detection-of-hepatocellular-carcinoma-in-cirrhotic-patients
#6
Ahmed M Tahon, Magdy Z El-Ghanam, Samy Zaky, Tarek Mostafa Emran, Ali M Bersy, Fathiya El-Raey, Elsayed A Z, Amr M El Kharsawy, Dina Johar
BACKGROUND: Egypt has high incidence of hepatocellular carcinoma (HCC). This is due to wide spread of hepatitis C virus (HCV) infection which is responsible for most of the cases of liver cirrhosis. The major diagnostic techniques for HCC include serum markers and various imaging modalities. Glypican 3 (GPC3) protein is highly expressed in HCC, but not in normal liver tissue. The significance of GPC3 as a predictor or diagnostic tool for human tumors other than HCC is unclear. AIM: To quantitatively assess the role of GPC3 in diagnosis of HCC in comparison to α-fetoprotein (AFP), ultrasonography (US), and computerized tomography (CT)...
April 6, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29611624/design-synthesis-biological-evaluations-molecular-docking-and-in-vivo-studies-of-novel-phthalimide-analogs
#7
Magdy A H Zahran, Bishoy El-Aarag, Ahmed B M Mehany, Amany Belal, Ali S Younes
A series of novel phthalimide analogs containing an indole or brominated indole moiety were synthesized and their antimicrobial activity was evaluated. Compound 8 showed a broad spectrum activity, revealing 53-67% of erythromycin activity on the tested bacteria and 60-70% of miconazole activity on the tested fungi. Anticancer activity was evaluated on the cell lines HepG2, MCF-7, A549, H1299, and Caco2. The results revealed that the new phthalimide analog 8 has broad-spectrum anticancer activity toward all the tested cancer cell lines, followed by compound 11, which showed good activity toward all the tested cell lines except for MCF-7...
April 3, 2018: Archiv der Pharmazie
https://www.readbyqxmd.com/read/29605099/crispr-cas13-as-a-tool-for-rna-interference
#8
Zahir Ali, Ahmed Mahas, Magdy Mahfouz
Almost all biological processes involve RNA, making it crucial to develop tools for manipulation of the transcriptome. The bacterial CRISPR/Cas13 system was recently rewired to facilitate RNA manipulation in eukaryotes, including plants. We discuss here the opportunities and limitations of using CRISPR/Cas13 in plants for various types of RNA manipulation.
May 2018: Trends in Plant Science
https://www.readbyqxmd.com/read/29484231/the-role-of-the-neurometer-cpt-c-in-sacral-neuromodulation
#9
Abdullah Ahmed Ghazi, Malak Abuzgaya, Mai Banakhar, Magdy Hassouna
Objective: The aim of the current research project was to study the role of the Neurometer® as a tool to predict responders to sacral neuromodulation therapy (SNM). Material and methods: This was a prospective, open study in male and female patients, aged 18 and over with voiding dysfunction [non-obstructive retention and/or frequency/ urgency syndrome]. The first group underwent a screening test to evaluate percutaneous nerve functions (PNE) and to determine whether they are candidates for SNM with the InterStim® ...
January 2018: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29484070/embolization-of-congenital-intercostobronchial-trunk-pulmonary-artery-fistula-using-amplatzer-vascular-plugs
#10
Souheil Saddekni, Amr Ahmed Abouateya, Rafik Mohamed Ibrahim, Maysoon Farouk Hamed, Sherif Magdy Moawad, Ahmed Anwar Abouarab, Ahmed Kamel Abdel Aal
We present the case of a 54-year-old male patient diagnosed with a right upper lobe lung cancer and was referred for resection. Positron emission tomography-computed tomography scan showed a prominent vascular structure in the right lung, suspicious for vascular malformation. A computed tomography angiography was done, demonstrating an intercostobronchial trunk-pulmonary artery fistula. There was also non-tapering dilated wandering pulmonary artery coursing through the right lower lung without any abnormal connection with pulmonary veins and were supplying normal lung parenchyma...
December 2017: Radiology Case Reports
https://www.readbyqxmd.com/read/29455633/placental-growth-factor-vascular-endothelial-growth-factor-and-hypoxia-inducible-factor-1%C3%AE-in-the-placentas-of-women-with-pre-eclampsia
#11
Lobna E Ali, Magdi M Salih, Elhassan M Elhassan, Ahmed A Mohmmed, Ishag Adam
BACKGROUND: Although the exact mechanism of pre-eclampsia - high blood pressure and proteinuria after 20 gestational weeks - is not yet fully understood, placental growth factor (PLGF), vascular endothelial growth factor (VEGF), and hypoxia-inducible factor (HIF) are known to play important roles in vascularization and in the pathology of pre-eclampsia. METHODS: PLGF, VEGF, and HIF-1α were evaluated by immunohistochemistry in the placentas of Sudanese women with mild or severe pre-eclampsia, and in normal controls...
February 28, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29451863/efficacy-of-three-different-regimens-in-recovery-of-bowel-function-following-elective-cesarean-section-a-randomized-trial
#12
Magdy Refaat Ahmed, Waleed Ali Sayed Ahmed, Rasha Elsayed Khamess, Manar S Youwakim, Khaled Mohamed El-Nahas
AIM: To compare the efficacy of three postoperative feeding regimens on bowel function recovery after term elective cesarean section (CS). METHODS: Women recruited for this randomized trial were allocated into three groups. Women in group (A) were instructed to chew sugarless gum for 10 min every 2 h after surgery. Group (B) mothers received IV fluids for 6 h followed by sipping fruit juices sweetened with honey. Group (C) had oral intake of clear fluids after passage of flatus and regular diet with the passage of bowel movement...
February 16, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29370886/functional-outcome-and-health-related-quality-of-life-after-dual-mobility-cup-total-hip-replacement-for-displaced-femoral-neck-fractures-in-middle-aged-egyptian-patients
#13
Ramy Ahmed Rashed, Hannah Sevenoaks, Amira Mohammed Shabaan, Qaisar Akhlaq Choudry, Abdullah Said Hammad, Mohammed Samir Kasem, Tarek Aly El Khadrawe, Magdy Mohammed El Dakhakhny
AIM: This study was done to assess the functional and clinical results after one year of cemented THR with dual mobility cup for the treatment of fracture neck femur in active middle-aged patients in Egypt (Middle Eastern population). PATIENTS AND METHODS: This study included 31 patients (32 hips) with displaced femoral neck fractures that were admitted to El Hadara University Hospital, Alexandria, Egypt. Their mean age was 66.4 ± 5.9 years. Fifteen patients were females...
March 2018: Injury
https://www.readbyqxmd.com/read/29319234/comparative-pharmacokinetics-of-trandolapril-its-active-metabolite-and-verapamil-in-human-plasma-of-egyptian-population-using-hplc-ms-ms
#14
Ragaa Magdy, Ahmed H El-Khatib, Ahmed Hemdan, Omar Abd Elaziz, Maha Farouk, Michael W Linscheid
Trandolapril and verapamil are commonly used antihypertensive drugs. However, there is a lack of available data on the change of their pharmacokinetics in patients with liver or kidney impairment and hence the need for dose adjustment. In this article, a high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was developed and validated for the monitoring of trandolapril, its active metabolite trandolaprilat, and verapamil in human plasma of patients with renal impairment and/or liver insufficiency...
January 10, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29301551/rna-virus-interference-via-crispr-cas13a-system-in-plants
#15
Rashid Aman, Zahir Ali, Haroon Butt, Ahmed Mahas, Fatimah Aljedaani, Muhammad Zuhaib Khan, Shouwei Ding, Magdy Mahfouz
BACKGROUND: CRISPR/Cas systems confer immunity against invading nucleic acids and phages in bacteria and archaea. CRISPR/Cas13a (known previously as C2c2) is a class 2 type VI-A ribonuclease capable of targeting and cleaving single-stranded RNA (ssRNA) molecules of the phage genome. Here, we employ CRISPR/Cas13a to engineer interference with an RNA virus, Turnip Mosaic Virus (TuMV), in plants. RESULTS: CRISPR/Cas13a produces interference against green fluorescent protein (GFP)-expressing TuMV in transient assays and stable overexpression lines of Nicotiana benthamiana...
January 4, 2018: Genome Biology
https://www.readbyqxmd.com/read/29298468/radiographic-position-of-the-electrode-as-a-predictor-of-the-outcome-of-interstim-therapy
#16
Abdullah Ahmed Gahzi, Mai Ahmed Banakhar, Dean S Elterman, Magdy Hassouna
PURPOSE: Sacral neuromodulation (SNM) therapy is indicated for some refractory urological conditions. The electrode lead position in sacral x-rays during routine follow-up may predict the outcome of SNM therapy. To determine whether the radiographic position of the electrode in the sacral foramen predicted the long-term outcome of SNM therapy. METHODS: This was a retrospective study of patients who underwent InterStim SNM at Toronto Western Hospital by 2 surgeons from July 2013 to March 2014...
December 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/29281919/terretonin-m-a-new-meroterpenoid-from-the-thermophilic-aspergillus-terreus-tm8-and-revision-of-the-absolute-configuration-of-penisimplicins
#17
Mohamed Shaaban, Mohammad Magdy El-Metwally, Ahmed Adel Abdel-Razek, Hartmut Laatsch
Terretonin M (1), a new highly oxygenated tetracyclic meroterpenoid, was isolated from the thermophilic fungus Aspergillus terreus TM8 together with 10 known metabolites: terrelumamide A, asterrelenin, 7-prenyl-indolyl-3-carbaldehyde, (3β,5α,6β)-3,5,6-trihydroxy-ergosta-7,22-diene, sitostenone, linoleic acid, ergosterol, uracil, p-hydroxy-benzoic acid, and indole-3-carboxylic acid. The chemical structure of the new compound was elucidated by extensive 1D, 2D NMR, and ESI HR mass measurements, and by comparison with literature data...
December 27, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29275040/radiosynthesis-and-modified-quality-control-of-o-2-18-f-fluoroethyl-l-tyrosine-18-f-fet-for-brain-tumor-imaging
#18
Ibrahim Saber Siddiq, Shoukar Tawfik Atwa, Sayed Ahmed Shama, Magdy Hafez Eltaoudy, Walid Mohamed Omar
O-(2-[18 F]fluoroethyl)-L-tyrosine ([18 F]FET) is the most promising radio-labeled amino acid tracer for brain tumor imaging due to the limitation of 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) and L-methyl-[11 C]methionine (11 C-MET). However, it has some limitations in radiosynthesis and related quality control that make it less frequently used in many PET centers, in this study, we report a new modification of [18 F]FET production using a commercially available fully automated GRP SCINTOMICS module overcoming some of the existing limitations along with a suggestion of a simplified quality control procedure with special focus placed on enantiomeric and radiochemical purity...
March 2018: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29219854/reconstruction-of-the-scapula-in-pediatric-and-adolescent-patients-after-total-scapulectomy-a-report-of-10-patients-treated-by-extracorporeal-irradiation-and-reimplantation-of-the-scapula
#19
Ahmed M El Ghoneimy, Mohamed S Zaghloul, Iman Zaky, Hala Taha, Ahmed Elgammal, Magdy El Sherbiny, Nehal Kamal
BACKGROUND: Ewing sarcoma of the scapula is uncommon. Restoration of shoulder function after total scapulectomy is challenging. Extracorporeal irradiation and reimplantation is a well-known method of biological reconstruction in orthopaedic oncology; yet very few reports in the literature describe its specific use in tumors of the scapula. PATIENTS AND METHODS: Ten patients with the diagnosis of Ewing sarcoma of the scapula were surgically treated by total scapulectomy and extracorporeal irradiation and reimplantation of the scapula...
February 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29197619/harnessing-crispr-cas-systems-for-programmable-transcriptional-and-post-transcriptional-regulation
#20
REVIEW
Ahmed Mahas, C Neal Stewart, Magdy M Mahfouz
Genome editing has enabled broad advances and novel approaches in studies of gene function and structure; now, emerging methods aim to precisely engineer post-transcriptional processes. Developing precise, efficient molecular tools to alter the transcriptome holds great promise for biotechnology and synthetic biology applications. Different approaches have been employed for targeted degradation of RNA species in eukaryotes, but they lack programmability and versatility, thereby limiting their utility for diverse applications...
January 2018: Biotechnology Advances
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