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https://www.readbyqxmd.com/read/30005359/engineering-virus-resistance-via-crispr-cas-systems
#1
REVIEW
Ahmed Mahas, Magdy Mahfouz
In prokaryotes, CRISPR/Cas adaptive immunity systems target and destroy nucleic acids derived from invading bacteriophages and other foreign genetic elements. In eukaryotes, the native function of these systems has been exploited to combat viruses in mammals and plants. Rewired CRISPR/Cas9 and CRISPR/Cas13 systems have been used to confer resistance against DNA and RNA viruses, respectively. Here, we discuss recent approaches employing CRISPR/Cas systems to combat viruses in eukaryotes, highlight key challenges, and provide future perspectives...
July 10, 2018: Current Opinion in Virology
https://www.readbyqxmd.com/read/29954242/uterine-artery-flow-velocity-waveform-fvw-type-and-subednometrial-vascularity-in-recurrent-pregnancy-loss
#2
Ghada M Mansour, Sherif H Hussein, Rasha M Abd El Hady, Haitham F Mohammed, Magdy M Abd El Gawad, Ahmed I Abou Gabal, Rania M Al-Awadhy, Mohamed E L Saied
PURPOSE: To assess the sub endometrial and uterine artery blood flow and pattern of waveform of uterine artery in cases of recurrent pregnancy loss, compared to normal controls. SUBJECTS AND METHODS: Fifty women with a history of two or more successive pregnancy losses were investigated by Doppler transvaginal ultrasound to assess the sub endometrial blood flow resistance index, type of Doppler waveform of uterine artery, and uterine artery pulsatility index in the midluteal phase...
June 28, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29954009/distally-based-peroneus-brevis-muscle-flap-for-large-leg-ankle-and-foot-defects-anatomical-finding-and-clinical-application
#3
Magdy Ahmed Abd-Al-Moktader
BACKGROUND:  Peroneus brevis muscle flap is a distinguished, distally based safe flap that can be manipulated to cover small defects in the leg and ankle. For large-sized defects, a more distal, larger flap is required either locally or distantly. METHODS:  Forty-two distally based peroneus brevis muscle flaps were elevated in 42 patients (30 males and 12 females) with major lower leg, ankle, and proximal foot defects of 6 to 15 cm in length and 6 to 12 cm in width...
June 28, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29953735/response-surface-design-as-a-powerful-tool-for-the-development-of-environmentally-benign-hplc-methods-for-the-determination-of-two-antihypertensive-combinations-greenness-assessment-by-two-green-analytical-chemistry-evaluation-tools
#4
Ahmed Hemdan, Ragaa Magdy, Maha Farouk
Interest in implementing green chemistry principles in analytical chemistry has grown dramatically in the past few years. The solvents used have the major influence on the greenness of the method. Most conventional high-performance liquid chromatography methods employed utilize solvents that are "hazardous for the environment". In the present study, two-factor three-level response surface design was exploited to develop eco-friendly chromatographic methods for two different mixtures. The first one was Atorvastatin and Amlodipine and the second one was Amlodipine, Perindopril, and Indapamide...
June 28, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29948635/diagnostic-accuracy-of-multi-slice-computed-tomography-in-identifying-lesion-characteristics-in-coronary-total-occlusion
#5
Islam Abdelmoneim, Ayman Sadek, Mohamed Ahmed Mosaad, Ibrahim Yassin, Yasser Radwan, Khalid Shokry, Ahmed Magdy, Mohammed Yasser Elsherbeny, Abdelrahman Ibrahim Abushouk
We performed this study to compare the sensitivity and specificity of multi-slice computed tomography (MSCT) to coronary angiography (CA) in detecting coronary total occlusion (CTO) lesion characteristics. Moreover, we analyzed the association between these characteristics and the risk of revascularization failure. Fifty patients with confirmed CTO diagnosis were tried for revascularization using the antegrade (all 50) or retrograde (in failed nine antegrade interventions) approaches. Each patient underwent CA and MSCT before the intervention and data from both modalities were compared using the SPSS software...
June 8, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29945849/impact-of-the-international-nosocomial-infection-control-consortium-inicc-s-multidimensional-approach-on-rates-of-ventilator-associated-pneumonia-in-intensive-care-units-in-22-hospitals-of-14-cities-of-the-kingdom-of-saudi-arabia
#6
Hail M Al-Abdely, Yassir Khidir Mohammed, Victor D Rosenthal, Pablo W Orellano, Mohamed ALazhary, Eman Kaid, Anan Al-Attas, Ghadeer Hawsawi, Ashraf Kelany, Bedoor Hussein, Bayan Esam, Rami Altowerqi, Modhi A Alkamaly, Nader A Tawfic, Elinita Cruzpero, Raya M Al Rashidi, Reny Thomas, Apsia M Molano, Hessa A Al Enazy, Fatima M Al Adwani, Arlu M Casuyon Pahilanga, Sharifa Alatawi, Raslan Nakhla, Fatma M Al Adwani, Rosita Gasmin Aromin, Evangelina Balon Ubalde, Hanan Hanafy Diab, Nahla A Kader, Ibtesam Y Hassan Assiry, Fahad A Sawan, Hassan E Ammari, Alhasan M Mashiakhy, Elaine B Santiago, Christian M S Chua, Imee M Dalis, Haider M Arishi, Ruthelma Lozada, Ibrahim A M Al-Zaydani Asiri, Hala Ahmed, Al Jarie, Ali S M Al-Qathani, Halima Y Al-Alkami, Mervat AlDalaton, Siti J B Alih, Mohammed J Alaliany, Najla J Helali, Grace Sindayen, Annalyn A Malificio, Haya B Al Dossari, Abdulmajid G Algethami, Dia Mohamed, Leigh Yanne, Avigail Tan, Sheema Babu, Shatha M Abduljabbar, Hala Rushdi, Janice Fernandez, Waleed M Hussain, Renuga D Rajavel, Syed Z Bukhari, Abdullah A Turkistani, Jeyashri J Mushtaq, Eida Albeladi, Sally Aboushoushah, Nahed Qushmaq, Leide Shyrine, Jomol Philipose, Mohamed Raees, Nawal S AbdulKhalik, Marjory Madco, Mohd Abdulghany, Athena Manao, Catherine Acostan, Rania Safwat, Muhammad Halwani, Nahla A H Abdul Aal, Anumol Thomas, Shaymaa M Abdulatif, Nelia C Ariola, Aisha H Mutwalli, Nelia Ariola, Eatedal Bohlega, Saly Simon, Estelita Damlig, Sherin G Elsherbini, Ilama T Krishne, Sheela Abraham, Mohammed A Ali Karrar, Nisreen A Gosn, Abdulaziz A Al Hindi, Rasha N Jaha, Saeda M AlQahtani, Ali O Abdul Aziz, Nadia L Demaisip, Elizabeth Laungayan Cortez, Analen F Cabato, Jerlie M Gonzales Celiz, Mohammed A Al Raey, Saeed A Al Darani, Misbah R Aziz, Batool A Manea, Eslam Samy, Solita Briones, Radhika Krishnan, Saman S M Raees, Kehkashan Tabassum, Khalid M Ghalilah, Mohamed Alradady, Abdulrahim Al Qatri, Mafaten Chaouali, Magdy Elsisi, Hajer A Aldossary, Shehab Al-Suliman, Amina A Al Talib, Nadira Albaghly, Mohammad E Haqlre Mia, Manal M Al-Gethamy, Dhafer M Alamri, Adnan S Al-Saadi, Evelyn P Ayugat, Nawaf A Al Hazazi, Modi I Al Hussain, Yvonne Caminade, Ann J Santos, Mohamed H Abdulwahab, Bushra T A Al-Garni
BACKGROUND: To analyze the impact of the International Nosocomial Infection Control Consortium (INICC) Multidimensional Approach (IMA) and use of INICC Surveillance Online System (ISOS) on ventilator-associated pneumonia (VAP) rates in Saudi Arabia from September 2013 to February 2017. METHODS: A multicenter, prospective, before-after surveillance study on 14,961 patients in 37 intensive care units (ICUs) of 22 hospitals. During baseline, we performed outcome surveillance of VAP applying the definitions of the CDC/NHSN...
June 23, 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29895998/first-trimester-uterine-artery-pulsatility-index-and-maternal-serum-papp-a-and-plgf-in-prediction-of-preeclampsia-in-primigravida
#7
Mostafa Abdo Ahmed Salem, Islam Mohamed Magdi Ammar
Background: Preeclampsia is a heterogeneous disorder affecting different body systems and frequently associated with morbidity and mortality. Early preeclampsia prediction will reduce this associated morbidity and mortality as it will give the chance for frequent maternal and fetal surveillance and application of prophylactic procedures. Objective: The aim of this work is to evaluate the role of mean pulsatility index (PI) of the uterine arteries and maternal serum concentrations of pregnancy-associated plasma protein A (PAPP-A) and placental growth factor (PlGF) in early preeclampsia prediction in primigravida...
June 2018: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/29884493/aortic-root-dynamism-geometry-and-function-after-the-remodeling-operation-clinical-relevance
#8
Magdi H Yacoub, Heba Aguib, Mazen Abou Gamrah, Nairouz Shehata, Mohamed Nagy, Mohamed Donia, Yasmine Aguib, Hesham Saad, Soha Romeih, Ryo Torii, Ahmed Afifi, Su-Lin Lee
OBJECTIVES: Valve-conserving operations for aneurysms of the ascending aorta and root offer many advantages, and their use is steadily increasing. Optimizing the results of these operations depends on providing the best conditions for normal function and durability of the new root. METHODS: Multimodality imaging including 2-dimensional echocardiography, multislice computed tomography, and cardiovascular magnetic resonance combined with image processing and computational fluid dynamics were used to define geometry, dynamism and aortic root function, before and after the remodeling operation...
April 13, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29876769/impact-of-serum-soluble-programed-death-ligand-1-on-end-of-treatment-metabolic-response-of-diffuse-large-b-cell-lymphoma-patients
#9
Amro Mohamed Sedky El-Ghammaz, Hoda Ahmed Gadallah, Gihan Kamal, Mohammed Magdy Maher, Mohamad Ayed Mohamad
Programmed death ligand-1 (PD-L1) plays an important role in the immune evasion of cancer cells and, in turn, can influence the outcome of many malignancies. The serum soluble PD-L1 (sPD-L1) levels were measured in diffuse large B cell lymphoma (DLBCL) patients at diagnosis and at end of treatment. Their impact on end of treatment metabolic response was analyzed. Serum sPD-L1 level was significantly elevated in DLBCL patients at diagnosis than in controls (P < 0.001). Also, serum sPD-L1 level at diagnosis was significantly higher than that at end of treatment (P < 0...
June 6, 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29844867/the-effect-of-the-type-of-dietary-protein-on-the-development-of-ovarian-cancer
#10
Ahmed A A Taha, Masafumi Koshiyama, Noriomi Matsumura, Kaoru Abiko, Ken Yamaguchi, Jyunzo Hamanishi, Tsukasa Baba, Budiman Kharma, Ibrahim Hassanin Mohamed, Magdy Mohamed Ameen, Salah Ali Ismail, Ikuo Konishi, Masaki Mandai
We evaluated whether different dietary protein qualities (isocaloric diets involving animal (casein) or plant protein (soy protein) could inhibit the ovarian cancer growth in mice and improve their prognosis and whether chemotherapy had different tumor reducing effects on these mice. In the mice of the 20% plant protein group, the ovarian cancer growth at 5 weeks after tumor implantation was clearly reduced in comparison to the mice in the 20% animal protein group (p< 0.001). The serum levels of insulin and IGF-1 levels were both lower in the mice of the 20% plant protein group than in the mice of the 20% animal protein group (p<0...
May 8, 2018: Oncotarget
https://www.readbyqxmd.com/read/29755792/sofosbuvir-plus-daclatasvir-in-treatment-of-chronic-hepatitis-c-genotype-4-infection-in-a-cohort-of-egyptian-patients-an-experiment-the-size-of-egyptian-village
#11
Ossama Ashraf Ahmed, Eslam Safwat, Mohamed Omar Khalifa, Ahmed I Elshafie, Mohamed Hassan Ahmed Fouad, Mohamed Magdy Salama, Gina Gamal Naguib, Mohamed Mahmoud Eltabbakh, Ahmed Fouad Sherief, Sherief Abd-Elsalam
Background and Aims: As indicated by the World Health Organization (WHO), Egypt is positioned as the country with the world's highest prevalence of Hepatitis C virus (HCV). HCV is transmitted through unexamined blood transfusions, different employments of syringes, and poor cleansing, as per the WHO. Our study aimed at screening and management of chronic hepatitis C genotype 4 infected patients in Bardeen village, Sharkeya Governorate, Egypt, with Sofosbuvir plus Daclatasvir, as well as estimating the safety and efficacy of that regimen...
2018: International Journal of Hepatology
https://www.readbyqxmd.com/read/29747397/field-efficacy-of-an-attenuated-infectious-bronchitis-variant-2-virus-vaccine-in-commercial-broiler-chickens
#12
Mohamed A Elhady, Ahmed Ali, Walid H Kilany, Wael K Elfeil, Hytham Ibrahim, Ahmed Nabil, Ahmed Samir, Magdy El Sayed
Egyptian poultry suffer from frequent respiratory disease outbreaks associated with Infectious Bronchitis Virus (IBV) variant 2 strains (Egy/VarII). Different vaccination programs using imported vaccines have failed to protect the flocks from field challenge. Recent studies confirmed a successful protection using homologous strains as live attenuated vaccines. In this study, a newly developed live attenuated IB-VAR2 vaccine representing the GI-23 Middle East IBV lineage was evaluated in day-old commercial broilers in an IBV-endemic area...
May 9, 2018: Veterinary Sciences
https://www.readbyqxmd.com/read/29723110/polyamidoamine-pamam-dendrimers-as-potential-release-modulators-and-oral-bioavailability-enhancers-of-vardenafil-hydrochloride
#13
Mai Ahmed Tawfik, Mina Ibrahim Tadros, Magdy Ibrahim Mohamed
Vardenafil hydrochloride (VAR) is an erectile dysfunction treating drug. VAR has a short elimination half-life (4-5 h) and suffers low oral bioavailability (15%). This work aimed to explore the dual potential of VAR-dendrimer complexes as drug release modulators and oral bioavailability enhancers. VAR-dendrimer complexes were prepared by solvent evaporation technique using four dendrimer generations (G4.5, G5, G5.5 and G6) at three concentrations (190 nM, 380 nM and 950 nM). The systems were evaluated for intermolecular interactions, particle size, zeta potential, drug entrapment efficiency percentages (EE%) and drug released percentages after 2 h (Q2h ) and 24 h (Q24h )...
May 21, 2018: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29686365/multifunctional-activities-of-erf109-as-affected-by-salt-stress-in-arabidopsis
#14
Ahmed Bahieldin, Ahmed Atef, Sherif Edris, Nour O Gadalla, Ahmed M Ramadan, Sabah M Hassan, Sanaa G Al Attas, Magdy A Al-Kordy, Abdulrahman S M Al-Hajar, Jamal S M Sabir, Mahmoud E Nasr, Gamal H Osman, Fotouh M El-Domyati
Transcriptomic analysis was conducted in leaves of Arabidopsis T-DNA insertion ERF109-knocked out (KO) mutant or plants overexpressing (OE) the gene to detect its role in driving expression of programmed cell death- (PCD-) or growth-related genes under high salt (200 mM NaCl) stress. The analysis yielded ~22-24 million reads, of which 90% mapped to the Arabidopsis reference nuclear genome. Hierarchical cluster analysis of gene expression and principal component analysis (PCA) successfully separated transcriptomes of the two stress time points...
April 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29681097/philtrum-length-and-intercommissural-distance-measurements-at-mixed-dentition-period
#15
Mostafa Mostafa, Nehal Hassib, Inas Sayed, Amany Neamat, Magda Ramzy, Tarek El-Badry, Hisham ElGabry, Haidy Salem, Nada Omar, Amira Ismail, Yousra Ibrahim, Amr Shebaita, Ahmed Allam, Magdy Mostafa
Anthropometric measurements of the lip and mouth are of great importance in clinical dysmorphology as well as reconstructive plastic surgery. In this study, the philtrum length (PhL) and intercommissural distance (ICmD) nomograms for Egyptian children in the mixed dentition period were established. A group of 1,338 Egyptian students in primary schools (735 boys and 603 girls) were included in the study. The students were at mixed dentition period and their ages ranged from 7 to 12 years. Anthropometric norms of PhL and ICmD were developed with significant sex difference in certain groups...
May 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29623600/significance-of-glypican-3-in-early-detection-of-hepatocellular-carcinoma-in-cirrhotic-patients
#16
Ahmed M Tahon, Magdy Z El-Ghanam, Samy Zaky, Tarek Mostafa Emran, Ali M Bersy, Fathiya El-Raey, Elsayed A Z, Amr M El Kharsawy, Dina Johar
BACKGROUND: Egypt has high incidence of hepatocellular carcinoma (HCC). This is due to wide spread of hepatitis C virus (HCV) infection which is responsible for most of the cases of liver cirrhosis. The major diagnostic techniques for HCC include serum markers and various imaging modalities. Glypican 3 (GPC3) protein is highly expressed in HCC, but not in normal liver tissue. The significance of GPC3 as a predictor or diagnostic tool for human tumors other than HCC is unclear. AIM: To quantitatively assess the role of GPC3 in diagnosis of HCC in comparison to α-fetoprotein (AFP), ultrasonography (US), and computerized tomography (CT)...
April 6, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29611624/design-synthesis-biological-evaluations-molecular-docking-and-in-vivo-studies-of-novel-phthalimide-analogs
#17
Magdy A H Zahran, Bishoy El-Aarag, Ahmed B M Mehany, Amany Belal, Ali S Younes
A series of novel phthalimide analogs containing an indole or brominated indole moiety were synthesized and their antimicrobial activity was evaluated. Compound 8 showed a broad spectrum activity, revealing 53-67% of erythromycin activity on the tested bacteria and 60-70% of miconazole activity on the tested fungi. Anticancer activity was evaluated on the cell lines HepG2, MCF-7, A549, H1299, and Caco2. The results revealed that the new phthalimide analog 8 has broad-spectrum anticancer activity toward all the tested cancer cell lines, followed by compound 11, which showed good activity toward all the tested cell lines except for MCF-7...
May 2018: Archiv der Pharmazie
https://www.readbyqxmd.com/read/29605099/crispr-cas13-as-a-tool-for-rna-interference
#18
Zahir Ali, Ahmed Mahas, Magdy Mahfouz
Almost all biological processes involve RNA, making it crucial to develop tools for manipulation of the transcriptome. The bacterial CRISPR/Cas13 system was recently rewired to facilitate RNA manipulation in eukaryotes, including plants. We discuss here the opportunities and limitations of using CRISPR/Cas13 in plants for various types of RNA manipulation.
May 2018: Trends in Plant Science
https://www.readbyqxmd.com/read/29484231/the-role-of-the-neurometer-cpt-c-in-sacral-neuromodulation
#19
Abdullah Ahmed Ghazi, Malak Abuzgaya, Mai Banakhar, Magdy Hassouna
Objective: The aim of the current research project was to study the role of the Neurometer® as a tool to predict responders to sacral neuromodulation therapy (SNM). Material and methods: This was a prospective, open study in male and female patients, aged 18 and over with voiding dysfunction [non-obstructive retention and/or frequency/ urgency syndrome]. The first group underwent a screening test to evaluate percutaneous nerve functions (PNE) and to determine whether they are candidates for SNM with the InterStim® ...
January 2018: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29484070/embolization-of-congenital-intercostobronchial-trunk-pulmonary-artery-fistula-using-amplatzer-vascular-plugs
#20
Souheil Saddekni, Amr Ahmed Abouateya, Rafik Mohamed Ibrahim, Maysoon Farouk Hamed, Sherif Magdy Moawad, Ahmed Anwar Abouarab, Ahmed Kamel Abdel Aal
We present the case of a 54-year-old male patient diagnosed with a right upper lobe lung cancer and was referred for resection. Positron emission tomography-computed tomography scan showed a prominent vascular structure in the right lung, suspicious for vascular malformation. A computed tomography angiography was done, demonstrating an intercostobronchial trunk-pulmonary artery fistula. There was also non-tapering dilated wandering pulmonary artery coursing through the right lower lung without any abnormal connection with pulmonary veins and were supplying normal lung parenchyma...
December 2017: Radiology Case Reports
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