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https://www.readbyqxmd.com/read/29407555/enhanced-transdermal-delivery-of-ondansetron-using-nanovesicular-systems-fabrication-characterization-optimization-and-ex-vivo-permeation-study-box-cox-transformation-practical-example
#1
Basant A Habib, Sinar Sayed, Ghada M Elsayed
This study aimed to formulate suitable nanovesicles (NVs) for transdermal delivery of Ondansetron. It also illustrated a practical example for the importance of Box-Cox transformation. A 23 full factorial design was used to enable testing transfersomes, ethosomes, and transethosomes of Ondansetron simultaneously. The independent variables (IVs) studied were sodium taurocholate amount, ethanol volume in hydration medium and sonication time. The studied dependent variables (DVs) were: particle size (PS), zeta potential (ZP) and entrapment efficiency (EE)...
January 30, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29133980/tailored-nanostructured-platforms-for-boosting-transcorneal-permeation-box-behnken-statistical-optimization-comprehensive-in-vitro-ex-vivo-and-in-vivo-characterization
#2
Ibrahim Elsayed, Sinar Sayed
Ocular drug delivery systems suffer from rapid drainage, intractable corneal permeation and short dosing intervals. Transcorneal drug permeation could increase the drug availability and efficiency in the aqueous humor. The aim of this study was to develop and optimize nanostructured formulations to provide accurate doses, long contact time and enhanced drug permeation. Nanovesicles were designed based on Box-Behnken model and prepared using the thin film hydration technique. The formed nanodispersions were evaluated by measuring the particle size, polydispersity index, zeta potential, entrapment efficiency and gelation temperature...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28480807/tri-block-co-polymer-nanocarriers-for-enhancement-of-oral-delivery-of-felodipine-preparation-in-vitro-characterization-and-ex-vivo-permeation
#3
Sinar Sayed, Basant A Habib, Ghada M Elsayed
This study aimed to prepare, optimize and characterize novel felodipine-loaded polymeric nanomicelles, using a pluronic mixture of F127 and P123. Thin-film hydration method was adopted for the preparation of different polymeric nanomicelles (T1-T12) according to a 4(1).3(1) full factorial design. Factors studied were: Pluronic®:drug ratio (P:D ratio) (10, 20, 30 and 40 w/w) and percent of hydrophilic polymer (F127%) (33.33%, 50% and 66.67% w/w). Optimization criteria were to maximize transmittance percent (T%) and entrapment efficiency percent (EE%) and to minimize particle size (PS) and polydispersity index (PDI)...
May 25, 2017: Journal of Liposome Research
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