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https://www.readbyqxmd.com/read/29169218/laccase-fermentation-of-clove-extract-increases-content-of-dehydrodieugenol-which-has-neuroprotective-activity-against-glutamate-toxicity-in-ht22-cells
#1
Han-Saem Lee, Eun-Ju Yang, Taeho Lee, Kyung-Sik Song
Enzyme fermentation is a type of food processing technique generally used to improve the biological activities of food and herbal medicines. In this study, the Syzygium aromaticum (clove) extract was fermented using laccase derived from Trametes versicolor (LTV). The fermented clove extract showed greater neuroprotective effects against glutamate toxicity on HT22 than the non-fermented extract did. HPLC analysis revealed that eugenol (1) and dehydrodieugenol (2) contents had decreased and increased, respectively, after fermentation...
November 25, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29168730/comparative-proteomics-analyses-of-pollination-response-in-endangered-orchid-species-dendrobium-chrysanthum
#2
Wei Wang, Hongyang Yu, Tinghai Li, Lexing Li, Guoqiang Zhang, Zhongjian Liu, Tengbo Huang, Yongxia Zhang
Pollination is a crucial stage in plant reproductive process. The self-compatibility (SC) and self-incompatibility (SI) mechanisms determined the plant genetic diversity and species survival. D. chrysanthum is a highly valued ornamental and traditional herbal orchid in Asia but has been declared endangered. The sexual reproduction in D. chrysanthum relies on the compatibility of pollination. To provide a better understanding of the mechanism of pollination, the differentially expressed proteins (DEP) between the self-pollination (SP) and cross-pollination (CP) pistil of D...
November 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29168595/berberine-impairs-embryonic-development-in-vitro-and-in-vivo-through-oxidative-stress-mediated-apoptotic-processes
#3
Chien-Hsun Huang, Zi-Wei Huang, Feng-Ming Ho, Wen-Hsiung Chan
Berberine, an isoquinoline alkaloid isolated from several traditional Chinese herbal medicines, has been shown to suppress growth and induce apoptosis in some tumor cell lines. However, berberine has also been reported to attenuate H2 O2 -induced oxidative injury and apoptosis. The basis for these ambiguous effects of berberine-triggering or preventing apoptosis-has not been well characterized to date. In the current investigation, we examined whether berberine exerts cytotoxic effects on mouse embryos at the blastocyst stage and affects subsequent embryonic development in vitro and in vivo...
November 23, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29168179/phenolic-and-physicochemical-stability-of-a-functional-beverage-powder-mixture-during-storage-effect-of-the-microencapsulant-inulin-and-food-ingredients
#4
Dalene de Beer, Claire E Pauck, Marique Aucamp, Wilna Liebenberg, Nicole Stieger, Marieta van der Rijst, Elizabeth Joubert
BACKGROUND: The need for a convenience herbal iced tea product with reduced kilojoules merited investigation of the shelf-life of powder mixtures containing a green Cyclopia subternata Vogel (honeybush) extract with proven blood glucose-lowering activity and alternative sweetener mixture. RESULTS: Prior to long-term storage testing, the wettability of powder mixtures containing food ingredients and the compatibility of their components were confirmed using the static sessile drop method and isothermal microcalorimetry, respectively...
November 23, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29167679/effects-of-mountain-uplift-and-climatic-oscillations-on-phylogeography-and-species-divergence-in-four-endangered-notopterygium-herbs
#5
Khurram Shahzad, Yun Jia, Fu-Lin Chen, Umar Zeb, Zhong-Hu Li
Mountain uplift and climatic fluctuations are important driving forces that have affected the geographic distribution and population dynamics history of organisms. However, it is unclear how geological and climatic events might have affected the phylogeographic history and species divergence in high-alpine herbal plants. In this study, we analyzed the population demographic history and species differentiation of four endangered Notopterygium herbs on the high-altitude Qinghai-Tibetan Plateau (QTP) and adjacent areas...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29167659/balancing-herbal-medicine-and-functional-food-for-prevention-and-treatment-of-cardiometabolic-diseases-through-modulating-gut-microbiota
#6
REVIEW
Ming Lyu, Yue-Fei Wang, Guan-Wei Fan, Xiao-Ying Wang, Shuang-Yong Xu, Yan Zhu
It has become apparent that gut microbiota is closely associated with cardiometabolic diseases (CMDs), and alteration in microbiome compositions is also linked to the host environment. Next generation sequencing (NGS) has facilitated in-depth studies on the effects of herbal medicine and functional food on gut microbiota. Both herbal medicine and functional food contain fiber, polyphenols and polysaccharides, exerting prebiotics-like activities in the prevention and treatment of CMDs. The administrations of herbal medicine and functional food lead to increased the abundance of phylum Bacteroidetes, and genus Akkermansia, Bifidobacteria, Lactobacillus, Bacteroides and Prevotella, while reducing phylum Firmicutes and Firmicutes/Bacteroidetes ratio in gut...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29166937/a-putative-chondroprotective-role-for-il-1%C3%AE-and-mpo-in-herbal-treatment-of-experimental-osteoarthritis
#7
Nora M Aborehab, Mahitab H El Bishbishy, Abeer Refaiy, Nermien E Waly
BACKGROUND: Herbal treatment may have a chondroprotective and therapeutic effect on Osteoarthritis (OA). We investigated the mechanism of action of ginger and curcumin rhizomes cultivated in Egypt in treatment of OA in rat model. METHODS: Thirty-five albino rats were intra-articularly injected with Monosodium Iodoacetate in the knee joint. Ginger and curcumin was orally administered at doses of 200 and 400 mg/kg (F200 and F400). Serum levels of cartilage oligomeric matrix protein (COMP), hyaluronic acid (HA), malondialdehyde (MDA), myeloperoxidase (MPO), Interleukin-1 beta (IL-1β) and superoxide dismutase activity (SOD) were measured using ELISA...
November 22, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29166574/altered-tnf-%C3%AE-response-by-aconibal-%C3%A2-and-methotrexate-in-a-lipopolysaccharide-induced-setting-of-inflammatory-conditions-potential-on-a-synergistic-combination
#8
Gunhyuk Park, Seoung Hoon Lee, Ji-Ye Han, Dal-Seok Oh
ETHNOPHARMACOLOGICAL RELEVANCE: Aconitum carmichaelii (AC) is a common herbal medicine used as anti-inflammatory and analgesic agent in Eastern Asia. In Korea, a commercial processed AC (Aconibal(®)) is traditionally used to treat the symptoms of spondylosis deformans and rheumatic pain. AIM OF STUDY: Rheumatoid arthritis (RA) is systemic and auto-immune disease characterized by chronic inflammation. Methotrexate (MTX) is often the first-line therapy for RA. If MTX monotherapy is ineffective or RA is initially severe, adding a tumor necrosis factor (TNF)-α inhibitor to the treatment can be beneficial...
November 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29166255/chemical-burns-following-massage-with-chopped-pulsatilla-koreana
#9
Jinkyung Song, Sangpil Tae, Hongsil Joo, Sang-Yeul Lee, Kun-Yong Sung
Herbal massage is commonly used for cosmetic and antirheumatic purposes in the Republic of Korea. Cutaneous burns can complicate herbal massages, but this is a very rare occurrence. Pulsatilla koreana, the Korean pasque flower, is a species of the genus Pulsatilla from the Ranunculaceae family. It is a perennial plant native to Korea, where it is used in herbal and folk medicine for its antipyretic, analgesic, anti-inflammatory, astringent, and hemostatic effects. Three cases of burns as a result of herbal massages with Pulsatilla koreana are presented herein to increase public awareness about the adverse effects of products used incorrectly for herbal massage...
November 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29165401/systematic-overview-of-bacopa-monnieri-l-wettst-dominant-poly-herbal-formulas-in-children-and-adolescents
#10
REVIEW
James D Kean, Luke A Downey, Con Stough
Background: The Ayurvedic medicinal system employs a holistic approach to health, utilising the synergistic properties of organic resources. Research into the Ayurvedic herb Bacopa monnieri (L.) Wettst. (B.monnieri) has reported improvements in cognitive outcomes in child and adult populations. The aim of current review is to systematically assess and critically summarize clinical trials investigating B.monnieri-dominant poly-herbal formulas and their effects on the cognition, memory, learning, and behaviour in children and adolescents...
November 22, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29165101/therapeutic-potentials-and-cytochrome-p450-mediated-interactions-involving-herbal-products-indicated-for-diabetes-mellitus
#11
Cyprian Ogbonna Onyeji, Sharon I Igbinoba, Gbola Olayiwola
There has been an increase in the use of herbal products to complement conventional drugs in the treatment of various diseases especially in developing countries. This may be attributable to the relatively cost-effectiveness and ease of accessibility of these products as well as the perception of their safety profiles. However, there are numerous literature reports on herbs altering the pharmacokinetics and pharmacodynamics of other co-administered drugs thereby modulating the therapeutic outcomes. The prevalence of diabetes is on a steady increase worldwide and it is now identified as one of the main threats to human health...
November 20, 2017: Drug Metabolism Letters
https://www.readbyqxmd.com/read/29165100/phytochemicals-formulated-as-nanoparticles-inventions-recent-patents-and-future-prospects
#12
Namdeo Jadhav, Sameer Nadaf, Dipali Lohar, Pravin Ghagare, Trupti Powar
BACKGROUND: The quest to improve the therapeutic effectiveness of herbal drugs has driven rigorously the pharmaceutical research towards development of herbal nanoparticles. Till date, various approaches have been adopted for the design of herbal nanoparticles. METHODS: We carried out an organized search of bibliographic databases consisting of an ample number of published abstracts and research articles using a focused review questionaries and insertion/omission criteria...
November 19, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29164155/new-insights-into-the-mechanisms-of-chinese-herbal-products-on-diabetes-a-focus-on-the-bacteria-mucosal-immunity-inflammation-diabetes-axis
#13
REVIEW
Zezheng Gao, Qingwei Li, Xuemin Wu, Xuemin Zhao, Linhua Zhao, Xiaolin Tong
Diabetes, especially type 2, has been rapidly increasing all over the world. Although many drugs have been developed and used to treat diabetes, side effects and long-term efficacy are of great challenge. Therefore, natural health product and dietary supplements have been of increasing interest alternatively. In this regard, Chinese herbs and herbal products have been considered a rich resource of product development. Although increasing evidence has been produced from various scientific studies, the mechanisms of action are lacking...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/29163845/improved-medical-expenditure-and-survival-with-integration-of-traditional-chinese-medicine-treatment-in-patients-with-heart-failure-a-nationwide-population-based-cohort-study
#14
Ming-Yen Tsai, Wen-Long Hu, Jen-Huai Chiang, Yu-Chuen Huang, Shih-Yu Chen, Yu-Chiang Hung, Yung-Hsiang Chen
Background: No previous studies have evaluated the effects of traditional Chinese medicine (TCM) treatment on patients with heart failure (HF). Hence, in this study, we determined whether TCM treatment affects the healthcare burden and survival of HF patients. Methods: Samples were retrieved from the registry of catastrophic illness patients of the Taiwan National Health Insurance Research Database (NHIRD). Based on a frequency (1:1) matched case-control design, patients with HF between 2000 and 2010 were designated as cases (TCM users) and controls (non-TCM users)...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163745/possible-reversible-cerebral-vasoconstriction-syndrome-associated-with-eucalyptus-case-report
#15
Daniel Lapid, Mohtashim Arbaab Qureshi, Ihtesham Aatif Quresh, Mohammed Rauf Afzal, Alberto Maud, Gustavo J Rodriguez, Rakesh Khatri
Background: Reversible cerebral vasoconstrictive syndrome (RCVS) has characteristic clinical features, brain imaging and Angiographic features. The majority of RCVS cases are associated with the use of antidepressants, polysubstance abuse, and nasal decongestants. We here present a case that highlights the use of eucalyptus herbs as a possible precipitant factor for RCVS formation. Case Presentation: A 42-year-old woman presented to the emergency department with a tingling sensation on the right-hand side of her body and a two-week progressive throbbing severe holocranial headache radiating to the neck, with associated nausea, photophobia, and phonophobia...
October 2017: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/29163704/riparsaponin-isolated-from-homonoia-riparia-lour-induces-apoptosis-of-oral-cancer-cells
#16
Tiecheng Li, Lei Wang
Homonoia riparia Lour (Euphorbiaceae) is a known source of herbal medicine in China, and riparsaponin (RSP) is an active constituent isolated from H. riparia. The aim of the present study was to investigate the antitumor effect of RSP on human oral carcinoma cells and its potential underlying molecular mechanism. RSP was isolated from roots of H. riparia and identified using nuclear magnetic resonance. An MTT assay was used to evaluate the cytotoxicity of RSP on human oral carcinoma cells. Subsequently, DAPI staining was performed to investigate the apoptotic effect of RSP...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29163427/antimycobacterial-and-anti-inflammatory-mechanisms-of-baicalin-via-induced-autophagy-in-macrophages-infected-with-mycobacterium-tuberculosis
#17
Qingwen Zhang, Jinxia Sun, Yuli Wang, Weigang He, Lixin Wang, Yuejuan Zheng, Jing Wu, Ying Zhang, Xin Jiang
Tuberculosis (TB) remains a leading killer worldwide among infectious diseases and the effective control of TB is still challenging. Autophagy is an intracellular self-digestion process which has been increasingly recognized as a major host immune defense mechanism against intracellular microorganisms like Mycobacterium tuberculosis (Mtb) and serves as a key negative regulator of inflammation. Clinically, chronic inflammation surrounding Mtb can persist for decades leading to lung injury that can remain even after successful treatment...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29163163/guanxin-danshen-formulation-protects-against-myocardial-ischemia-reperfusion-injury-induced-left-ventricular-remodeling-by-upregulating-estrogen-receptor-%C3%AE
#18
Xuehong Deng, Xiaoyan Xing, Guibo Sun, Xudong Xu, Haifeng Wu, Guang Li, Xiaobo Sun
Background: Guanxin Danshen formulation (GXDSF) is a traditional Chinese herbal recipe recorded in the Chinese Pharmacopeia since 1995 edition, which consists of Salviae miltiorrhizae Radix et Rhizoma, Notoginseng Radix et Rhizoma and Dalbergiae odoriferae Lignum. Our previous research suggested GXDSF had positive effect on cardiovascular disease. Therefore, the aim of this study was to elucidate the effects of GXDSF on myocardial ischemia reperfusion injury-induced left ventricular remodelling (MIRI-LVR). Methods: The effects of GXDSF on cardiac function were detected by haemodynamics and echocardiograms...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29162232/chemomics-based-marker-compounds-mining-and-mimetic-processing-for-exploring-chemical-mechanisms-in-traditional-processing-of-herbal-medicines-a-continuous-study-on-rehmanniae-radix
#19
Li Zhou, Jin-Di Xu, Shan-Shan Zhou, Hong Shen, Qian Mao, Ming Kong, Ye-Ting Zou, Ya-Yun Xu, Jun Xu, Song-Lin Li
Exploring processing chemistry, in particular the chemical transformation mechanisms involved, is a key step to elucidate the scientific basis in traditional processing of herbal medicines. Previously, taking Rehmanniae Radix (RR) as a case study, the holistic chemome (secondary metabolome and glycome) difference between raw and processed RR was revealed by integrating hyphenated chromatographic techniques-based targeted glycomics and untargeted metabolomics. Nevertheless, the complex chemical transformation mechanisms underpinning the holistic chemome variation in RR processing remain to be extensively clarified...
November 18, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29161660/molecular-mechanisms-of-anti-inflammatory-effect-of-chrysophanol-an-active-component-of-ast2017-01-on-atopic-dermatitis-in-vitro-models
#20
Hyun-Ja Jeong, Hee-Yun Kim, Hyung-Min Kim
AST2017-01 mainly consists of Rumex crispus and -Cordyceps militaris and has been widely consumed as an herbal medicine or functional food in Korea. Here we investigated the influences of AST2017-01 and its active component, chrysophanol on human mast cell (HMC-1 cell) and human keratinocyte (HaCaT cell)-mediated inflammatory reactions. Pretreatment with AST2017-01 or chrysophanol suppressed intracellular calcium levels and histamine release in phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-treated HMC-1 cells...
November 18, 2017: International Immunopharmacology
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