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https://www.readbyqxmd.com/read/29924943/peptidylarginine-deiminase-4-a-nuclear-button-triggering-neutrophil-extracellular-traps-in-inflammatory-diseases-and-aging
#1
Siu Ling Wong, Denisa D Wagner
Peptidylarginine deiminase 4 (PAD4) is a nuclear citrullinating enzyme that is critically involved in the release of decondensed chromatin from neutrophils as neutrophil extracellular traps (NETs). NETs, together with fibrin, are implicated in host defense against pathogens; however, the formation of NETs (NETosis) has injurious effects that may outweigh their protective role. For example, PAD4 activity produces citrullinated neoantigens that promote autoimmune diseases, such as rheumatoid arthritis, to which PAD4 is genetically linked and where NETosis is prominent...
June 20, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29924890/targeting-mmp-13-in-bronchial-epithelial-repair
#2
Christopher Howell, James R Smith, Janis K Shute
BACKGROUND: Viral infection of the bronchial epithelium disrupts the barrier properties of the epithelium in healthy individuals and those with lung disease. Repair of the bronchial epithelium is dependent of the formation of a provisional fibrin matrix and migration of epithelial cells to cover denuded areas, followed by proliferation and differentiation. OBJECTIVE: The objective was to test the hypothesis that poly I:C, a model of viral infection, limits epithelial repair through the stimulated release of matrix metalloproteinase-13 (MMP-13)...
June 20, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29924595/angiogenesis-and-full-thickness-wound-healing-efficiency-of-copper-doped-borate-bioactive-glass-poly-lactic-co-glycolic-acid-dressing-loaded-with-vitamin-e-in-vivo-and-in-vitro
#3
Haoran Hu, Yue Tang, Libin Pang, Cunlong Lin, Wenhai Huang, Deping Wang, Weitao Jia
There is an urgent demand for wound healing biomaterials because of the increasing frequency of traffic accidents, industrial contingencies and natural disasters. Borate bioactive glass has potential applications in bone tissue engineering and wound healing; however, its uncontrolled release runs a high risk of rapid degradation and transient biotoxicity. In this study, a novel organic-inorganic dressing of copper-doped borate bioactive glass/poly(lactic-co-glycolic acid) loaded with vitamin E (0-3.0 wt.% vitamin E) was fabricated to evaluate its efficiency for angiogenesis in cells and full-thickness skin wounds healing in rodents...
June 20, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29923901/treatment-of-genital-burn-injuries-traditional-procedures-and-new-techniques
#4
Alexandra Schulz, Benedikt Ribitsch, Paul Christian Fuchs, Alexandra Lipensky, Jennifer Lynn Schiefer
OBJECTIVE: Because genital burns are rare, only limited information on treatment guidelines is available in the literature. Vital tissue should be preserved to promote spontaneous healing because reconstruction does not always lead to satisfying results. The aim of this report is to present a general overview of current, prevailing treatment for genital burns and compare this to study authors' experiences. In addition, the article describes an entirely new approach of tissue-preserving bromelain-based enzymatic debridement of genital burn wounds...
July 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29922562/primary-double-eyelid-surgery-trapezoidal-debulking-of-upper-eyelid-tissues
#5
William P D Chen
The video illustrates the steps of Asian blepharoplasty of the upper eyelids, using the author's principle of beveled approach and trapezoidal debulking of preaponeurotic platform to allow safe access, minimization of wound injury, and creating a physiologically dynamic crease, without resorting to the use of buried sutures.
May 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29922542/bioprosthetic-versus-synthetic-mesh-analysis-of-tissue-adherence-and-revascularization-in-an-experimental-animal-model
#6
David M Adelman, Kevin G Cornwell
Background: Both synthetic and bioprosthetic meshes play important roles in surgical procedures such as ventral hernia repair. Although sometimes used interchangeably, these devices have inherently different properties. We therefore sought to better understand how these materials interact with the host environment to optimize surgical techniques and to improve outcomes. Methods: Synthetic mesh (polypropylene, Prolene) or bioprosthetic mesh (acellular fetal/neonatal bovine dermis, SurgiMend) was implanted intraperitoneally into rats lateral to a ventral incision in a novel intra-abdominal implant model...
May 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29921749/role-of-human-macrophage-polarization-in-inflammation-during-infectious-diseases
#7
REVIEW
Chiraz Atri, Fatma Z Guerfali, Dhafer Laouini
Experimental models have often been at the origin of immunological paradigms such as the M1/M2 dichotomy following macrophage polarization. However, this clear dichotomy in animal models is not as obvious in humans, and the separating line between M1-like and M2-like macrophages is rather represented by a continuum, where boundaries are still unclear. Indeed, human infectious diseases, are characterized by either a back and forth or often a mixed profile between the pro-inflammatory microenvironment (dominated by interleukin (IL)-1β, IL-6, IL-12, IL-23 and Tumor Necrosis Factor (TNF)-α cytokines) and tissue injury driven by classically activated macrophages (M1-like) and wound healing driven by alternatively activated macrophages (M2-like) in an anti-inflammatory environment (dominated by IL-10, Transforming growth factor (TGF)-β, chemokine ligand (CCL)1, CCL2, CCL17, CCL18, and CCL22)...
June 19, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29921702/cell-scientist-to-watch-sandra-rieger
#8
(no author information available yet)
Sandra Rieger studied at the University of Applied Sciences at Fulda, Germany, and wrote her diploma thesis in collaboration with Zyomyx, Inc. (San Francisco, USA). She then joined the laboratory of Reinhard Koester at the Helmholtz Center in Munich to complete her PhD in developmental neurobiology in 2008. For her postdoctoral studies, Sandra moved to the University of California, Los Angeles to work with Alvaro Sagasti on axon regeneration in zebrafish. Since 2011, she has been Assistant Professor for regenerative biology and medicine at the MDI Biological Laboratory in Maine, USA...
June 19, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29921037/hydrogen-gas-inhalation-protects-against-cutaneous-ischaemia-reperfusion-injury-in-a-mouse-model-of-pressure-ulcer
#9
Wei Fang, Guizhen Wang, Luyan Tang, Huilin Su, Huyan Chen, Wanqing Liao, Jinhua Xu
Pressure ulcer formation depends on various factors among which repetitive ischaemia/reperfusion(I/R) injury plays a vital role. Molecular hydrogen (H2 ) was reported to have protective effects on I/R injuries of various internal organs. In this study, we investigated the effects of H2 inhalation on pressure ulcer and the underlying mechanisms. H2 inhalation significantly reduced wound area, 8-oxo-dG level (oxidative DNA damage) and cell apoptosis rates in skin lesions. H2 remarkably decreased ROS accumulation and enhanced antioxidant enzymes activities by up-regulating expression of Nrf2 and its downstream components in wound tissue and/or H2 O2 -treated endothelia...
June 19, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29920914/robot-assisted-percutaneous-screw-placement-combined-with-pelvic-internal-fixator-for-minimally-invasive-treatment-of-unstable-pelvic-ring-fractures
#10
Hua-Shui Liu, Sheng-Jun Duan, Shi-Dong Liu, Feng-Shuang Jia, Li-Ming Zhu, Min-Cen Liu
PURPOSE: The purpose of this study was to investigate the safety and efficacy of the combination of robot-assisted percutaneous screw placement and pelvic internal fixator (INFIX) for minimally invasive treatment of unstable anterior and posterior pelvic ring injuries. METHODS: From September 2016 to June 2017, twenty-four patients with unstable anterior and posterior pelvic ring injuries were treated with TiRobot-assisted percutaneous sacroiliac cannulated screw fixation on the posterior pelvic ring combined with robot-assisted pedicle screw placement in the anterior inferior iliac spine along with INFIX on the anterior pelvic ring...
June 19, 2018: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/29920380/transvaginal-treatment-of-anterior-and-apical-genital-prolapses-using-an-ultra-lightweight-mesh-restorelle%C3%A2-direct-fixtm-a-retrospective-study-on-feasibility-and-morbidity
#11
Philippe Ferry, Pauline Bertherat, Anne Gauthier, Richard Villet, Francesco Del Piano, David Hamid, Hervé Fernandez, Pierre-Louis Broux, Delphine Salet-Lizée, Etienne Vincens, Pierre Ntshaykolo, Philippe Debodinance, Philippe Pocholle, Yannick Thirouard, Renaud de Tayrac
Vaginal mesh safety information is limited, especially concerning single incision techniques using ultra lightweight meshes for the treatment of anterior pelvic organ prolapse (POP). Objective To determine the intraoperative and postoperative complication rates after anterior POP repair involving an ultralight mesh (19kg/m2 ): Restorelle® Direct Fix™. Methods A case series of 218 consecutive patients, operated on between January 2013 and December 2016 in ten tertiary and secondary care centres, was retrospectively analysed...
June 16, 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29920363/wounding-induced-upregulation-of-the-bone-morphogenic-protein-signaling-pathway-in-drosophila-promotes-survival-against-parasitic-nematode-infection
#12
Jelena Patrnogic, Christa Heryanto, Ioannis Eleftherianos
The common fruit fly, Drosophila melanogaster is an outstanding model to analyze the regulation of conserved signaling pathways. In this study, we examined whether signaling components in the Bone Morphogenic Protein (BMP) branch of the TGF-β signaling pathway are involved in the response to wounding caused by either sterile injury or infection by parasitic nematodes in D. melanogaster adult flies. We found that following sterile injury, the BMP pathway Type I receptor sax and intracellular transcription factor Mad were substantially upregulated...
June 16, 2018: Gene
https://www.readbyqxmd.com/read/29920252/anti-allodynic-and-anti-hyperalgesic-activities-of-fentanyl-loaded-dermal-clay-fldc-dressings-in-rat-model-of-second-degree-burn-injury
#13
Srinath Rangappa, Krishnaswamy K Rangan, Tirumalai S Sudarshan, S Narasimha Murthy
Second degree burn injury is the most common type of burn injury which usually takes 2-3 weeks for complete healing. However, such patients suffer with intense pain associated with development of hyperalgesia and allodynia. Here, we prepare a silver clay patch using Montmorillonite clay, betaine and silver nitrate. Later, the silver clay patches were loaded with fentanyl. Further, the patches were fabricated into burn wound dressings. The dressings were first subjected to ex vivo skin penetration studies and were later evaluated for thermal hyperalgesia and mechanical allodynia using second degree burn injury rodent model...
June 16, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29917206/up-regulation-of-microrna-503-by-high-glucose-reduces-the-migration-and-proliferation-but-promotes-the-apoptosis-of-human-umbilical-vein-endothelial-cells-by-inhibiting-the-expression-of-insulin-like-growth-factor-1-receptor
#14
L-J Hou, J-J Han, Y Liu
OBJECTIVE: The present study is aimed to investigate the regulatory effect of microRNA (miRNA or miR)-503 on endothelial functions, as well as the mechanism by which high glucose leads to injury of endothelial cells. MATERIALS AND METHODS: When reaching 80% confluency, human umbilical vein endothelial cells (HUVECs) were subjected to non-serum synchronization for 12 h, and medium of cells in high-glucose (HG) group was replaced by normal medium supplemented with 25 mmol/L D-glucose...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29916991/risk-factors-for-early-reoperation-after-operative-treatment-of-acetabular-fractures
#15
Anthony Ding, Robert V OʼToole, Renan Castillo, Brad Reahl, Ryan Montalvo, Jason W Nascone, Marcus F Sciadini, Anthony R Carlini, Theodore T Manson
OBJECTIVES: To identify the risk factors for early reoperation after operative fixation of acetabular fractures. DESIGN: Retrospective evaluation. SETTING: Level I Trauma Center. PATIENTS: Seven hundred ninety-one patients with displaced acetabular fractures treated with open reduction and internal fixation (ORIF) from 2006 to 2015. Average follow-up was 52 weeks. MAIN OUTCOME MEASURES: Early reoperation after acetabular ORIF, defined as secondary procedure for infection or revision within 3 years of initial operation...
July 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29916226/the-effect-of-low-molecular-weight-heparin-on-salvaging-the-zone-of-stasis-in-an-experimental-burn-model
#16
Muhammet Uraloğlu, Murat Livaoğlu, Özgür Agdoğan, Şafak Ersöz, Naci Karaçal
Background/aim: Multiple zones of injuries are formed after burns, consisting of a zone of coagulative necrosis, a zone of hyperemia, and a zone of stasis, in which progressive microcirculatory thrombosis leads to degeneration and deepening of the wound. We used an experimental rat comb burn model to test the hypothesis that use of low molecular weight heparin (LMWH) may save the zone of stasis. Materials and methods: Adult female rats were randomly divided two groups: the LMWH group (n = 8) rats received subcutaneous LMWH injections, while the saline group (n = 8) rats were injected with the same volume of saline solution by the same route...
June 14, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29915632/incidence-causes-and-risk-factors-for-30-day-unplanned-reoperation-after-gastrectomy-for-gastric-cancer-experience-of-a-high-volume-center
#17
Hua Xiao, Yu Wang, Hu Quan, Yongzhong Ouyang
Background: To investigate the incidence, causes and risk factors for unplanned reoperation because of early complications within 30 days of radical gastrectomy for gastric cancer. Methods: The study cohort comprised 1,948 patients who underwent radical gastrectomy for gastric cancer between November 2010 and April 2017. The incidence, causes and outcomes of unplanned reoperation were examined and the risk factors were identified using univariate and multivariate analyses...
June 2018: Gastroenterology Research
https://www.readbyqxmd.com/read/29915573/functions-of-v%C3%AE-4-t-cells-and-dendritic-epidermal-t-cells-on-skin-wound-healing
#18
REVIEW
Yashu Li, Jun Wu, Gaoxing Luo, Weifeng He
Wound healing is a complex and dynamic process that progresses through the distinct phases of hemostasis, inflammation, proliferation, and remodeling. Both inflammation and re-epithelialization, in which skin γδ T cells are heavily involved, are required for efficient skin wound healing. Dendritic epidermal T cells (DETCs), which reside in murine epidermis, are activated to secrete epidermal cell growth factors, such as IGF-1 and KGF-1/2, to promote re-epithelialization after skin injury. Epidermal IL-15 is not only required for DETC homeostasis in the intact epidermis but it also facilitates the activation and IGF-1 production of DETC after skin injury...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29915541/adm-scaffolds-generate-a-pro-regenerative-microenvironment-during-full-thickness-cutaneous-wound-healing-through-m2-macrophage-polarization-via-lamtor1
#19
Chengmin He, Zhi Yang, Ying Jin, Xiaoyang Qi, Jin Chu, Xiaoyuan Deng
Adult mammalian skin has a defective regenerative capacity following full-thickness cutaneous injury; this defect overshadows the complete physiological functions of the skin. Immune-mediated skin reconstruction driven by biological scaffolds is a recently developed innovative repair strategy to support regenerative wound healing. However, to date, little is known about how biological scaffolds orchestrate the immune response to promote regeneration. Here, using acellular dermal matrix (ADM) scaffolds, we discovered that the default pro-inflammatory response was altered in response to a pro-regenerative response characterized by specific M2 polarization...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29914830/clinical-factors-that-influence-the-cellular-responses-of-saphenous-veins-used-for-arterial-bypass
#20
Michael Sobel, Shinsuke Kikuchi, Lihua Chen, Gale L Tang, Tom N Wight, Richard D Kenagy
OBJECTIVE: When an autogenous vein is harvested and used for arterial bypass, it suffers physical and biologic injuries that may set in motion the cellular processes that lead to wall thickening, fibrosis, stenosis, and ultimately graft failure. Whereas the injurious effects of surgical preparation of the vein conduit have been extensively studied, little is known about the influence of the clinical environment of the donor leg from which the vein is obtained. METHODS: We studied the cellular responses of fresh saphenous vein samples obtained before implantation in 46 patients undergoing elective lower extremity bypass surgery...
June 15, 2018: Journal of Vascular Surgery
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