keyword
MENU ▼
Read by QxMD icon Read
search

Fal

keyword
https://www.readbyqxmd.com/read/29241710/new-insights-into-the-gene-expression-associated-to-amyotrophic-lateral-sclerosis
#1
REVIEW
Daniela Recabarren-Leiva, Marcelo Alarcón
Amyotrophic lateral sclerosis (ALS) is the most prevalent neuromuscular disease worldwide. It is a lethal and progressive neurodegenerative disease, principally affecting motor neurons; patient clinical characteristics are muscle weakness, dysphagia and respiratory failure. The mean age is related to family history (40years, familial ALS or FALS) or with no family history (50years), but it is more common in people aged 60-69years. The cause of ALS is not known and it is not known yet why it affects some people and not others...
December 11, 2017: Life Sciences
https://www.readbyqxmd.com/read/29234142/a-molecular-chaperone-activity-of-ccs-restores-the-maturation-of-sod1-fals-mutants
#2
Enrico Luchinat, Letizia Barbieri, Lucia Banci
Superoxide dismutase 1 (SOD1) is an important metalloprotein for cellular oxidative stress defence, that is mutated in familiar variants of Amyotrophic Lateral Sclerosis (fALS). Some mutations destabilize the apo protein, leading to the formation of misfolded, toxic species. The Copper Chaperone for SOD1 (CCS) transiently interacts with SOD1 and promotes its correct maturation by transferring copper and catalyzing disulfide bond formation. By in vitro and in-cell NMR, we investigated the role of the SOD-like domain of CCS (CCS-D2)...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29198548/embolization-of-arterial-gastrointestinal-hemorrhage-with-fuaile-medical%C3%A2-adhesive
#3
Min Xu, Xiaoli Zhu, Yizhi Liu, Zhi Li, Tianzhi An, Tianpeng Jiang, Jie Song, Lizhou Wang, Shi Zhou, Caifang Ni
BACKGROUND: To investigate the safety and effectiveness of Fuaile medical adhesive (FAL) with superselective catheterization in endovascular embolotherapy for the treatment of gastrointestinal hemorrhage (GIH) that was unresponsive to internal medicine treatment and gastroscopy management. METHODS: A total of 25 patients with GIH, confirmed using angiography but with failed results after internal medicine treatment or gastroscopy were retrospectively analyzed. A mixture of lipiodol and FAL (1:1) was used to embolize the bleeding vessels...
November 30, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29197603/a-reliable-mouse-model-of-hindlimb-gangrene
#4
Punam P Parikh, Diego Castilla, Roberta M Lassance-Soares, Hongwei Shao, Manuela Regueiro, Yan Li, Roberto Vazquez-Padron, Keith A Webster, Zhao-Jun Liu, Omaida C Velazquez
INTRODUCTION: Lack of a reliable hindlimb gangrene animal model limits pre-clinical studies of gangrene, a severe form of critical limb ischemia (CLI). We develop a novel mouse hindlimb gangrene model to facilitate translational studies. METHODS: BALB/c, FVB and C57BL/6 mice underwent femoral artery ligation (FAL) with or without administration of NG-nitro-L-arginine methyl ester (L-NAME), an endothelial nitric oxide synthase (eNOS) inhibitor. Gangrene was assessed using standardized ischemia scores ranging from 0 (no gangrene) to 12 (forefoot gangrene)...
November 29, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29194436/characterisation-of-the-pathogenic-effects-of-the-in-vivo-expression-of-an-als-linked-mutation-in-d-amino-acid-oxidase-phenotype-and-loss-of-spinal-cord-motor-neurons
#5
Nazanin Rahmani Kondori, Praveen Paul, Jacqueline P Robbins, Ke Liu, John C W Hildyard, Dominic J Wells, Jacqueline S de Belleroche
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset neuromuscular disorder characterised by selective loss of motor neurons leading to fatal paralysis. Current therapeutic approaches are limited in their effectiveness. Substantial advances in understanding ALS disease mechanisms has come from the identification of pathogenic mutations in dominantly inherited familial ALS (FALS). We previously reported a coding mutation in D-amino acid oxidase (DAOR199W) associated with FALS. DAO metabolises D-serine, an essential co-agonist at the N-Methyl-D-aspartic acid glutamate receptor subtype (NMDAR)...
2017: PloS One
https://www.readbyqxmd.com/read/29170591/new-technological-interventions-in-conservation-conflicts-countering-emotions-and-contested-knowledge
#6
Audrey Verma, René van der Wal, Anke Fischer
New technologies have increasingly featured in environmental conservation conflicts. We examined the deployment of imaging devices such as sonar equipment and cameras to survey the Fal estuary in Cornwall, UK. Due to heavy use of these waters, there have been several disputes coalescing around protected marine features, including the estuary's rare maerl beds. A comparison of two cases, scallop dredging and docks development, showed technical instruments being deployed to produce information about the marine environment as evidence to inform decision-making...
2017: Human Ecology: An Interdisciplinary Journal
https://www.readbyqxmd.com/read/29164764/influence-of-levulinic-acid-hydrogenation-on-aluminum-coordination-in-zeolite-supported-ruthenium-catalysts-a%C3%A2-27-al-3qmas-nuclear-magnetic-resonance-study
#7
Wenhao Luo, Ernst R H van Eck, Pieter C A Bruijnincx, Bert M Weckhuysen
The influence of a highly oxygenated, polar protic reaction medium, that is, levulinic acid in 2-ethylhexanoic acid, on the dealumination of two zeolite-supported ruthenium catalysts, namely Ru/H-β and Ru/H-ZSM-5, has been investigated by (27) Al triple-quantum magic-angle spinning nuclear magnetic resonance spectroscopy (3QMAS NMR). Upon use of these catalysts in the hydrogenation of levulinic acid, the heterogeneity in aluminum speciation is found to increase for both Ru/H-ZSM-5 and Ru/H-β. For Ru/H-ZSM-5, the symmetric, tetrahedral framework aluminum species (FAL) were found to be mainly converted into distorted tetrahedral FAL species, with limited loss of aluminum to the solution by leaching...
November 22, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29157189/molecular-dynamics-of-a-far-positioned-sod1-mutant-v14m-reveals-pathogenic-misfolding-behavior
#8
Dharma Rao Tompa, K Saraboji
Human superoxide dismutase (Cu/Zn SOD1) is a homodimeric enzyme. Mutations in Cu/Zn SOD1 causes a familial form of amyotrophic lateral sclerosis (fALS), and aggregation of mutant SOD1 has been proposed to play a role in neurodegeneration. Though a majority of the mutations are point substitutions, there are a few changes that result in amino acid deletions or truncations of the polypeptide. These pathogenic mutations are scattered throughout the three-dimensional structure of the dimeric enzyme, which creates a puzzling pattern to investigate the molecular determinants of fALS...
November 20, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29136890/electro-acoustic-sensor-for-the-real-time-identification-of-the-bacteriophages
#9
О I Guliy, B D Zaitsev, I A Borodina, А М Shikhabudinov, S А Staroverov, L A Dykman, A S Fomin
The electro-acoustical sensor for the real-time identification of the bacteriophage FAl-SR65 is described. The polyclonal antibodies specific to the bacteriophage FAl-SR65 were for the first time obtained, and the possibility of their application to the bacteriophage detection by using the electro-acoustical method of analysis was also studied for the first time. The electro-acoustical sensor was based on the lateral electric field excited piezoelectric resonator. The frequency dependences of the real and imaginary parts of the electrical impedance of such a resonator, loaded with the virus-antibody suspension, significantly differed from those measured for the same resonator with the same virus suspension but without antibodies (control)...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29134510/drug-design-for-alk-positive-nsclc-an-integrated-pharmacophore-based-3d-qsar-and-virtual-screening-strategy
#10
Nivya James, V Shanthi, K Ramanathan
The increasing death rates related to anaplastic lymphoma kinase (ALK)-positive lung cancer culminated in a significant interest in the discovery of novel inhibitors for ALK. In the present research work, pharmacophore-based 3D QSAR modeling and virtual screening strategy have been carried out to address these issues. Initially, a five-point pharmacophore model was developed using the biological data of 50 compounds which includes an FDA-approved ALK inhibitor, crizotinib. Using the generated pharmacophore, a 3D QSAR model was developed and used as a query to screen the DrugBank database...
November 13, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29131108/genetic-and-pathological-assessment-of-hnrnpa1-hnrnpa2-b1-and-hnrnpa3-in-familial-and-sporadic-amyotrophic-lateral-sclerosis
#11
Jennifer A Fifita, Katharine Y Zhang, Jasmin Galper, Kelly L Williams, Emily P McCann, Alison L Hogan, Neil Saunders, Denis Bauer, Ingrid S Tarr, Roger Pamphlett, Garth A Nicholson, Dominic Rowe, Shu Yang, Ian P Blair
BACKGROUND: Mutations in the genes encoding the heterogeneous nuclear ribonucleoproteins hnRNPA1 and hnRNPA2/B1 have been reported in a multisystem proteinopathy that includes amyotrophic lateral sclerosis (ALS) and inclusion body myopathy associated with Paget disease of the bone and frontotemporal dementia. Mutations were also described in the prion-like domain of hnRNPA1 in patients with classic ALS. Another hnRNP protein, hnRNPA3, has been found to be associated with the ALS/frontotemporal dementia protein C9orf72...
November 11, 2017: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/29119072/a-comparison-of-visual-outcomes-and-patient-satisfaction-between-photorefractive-keratectomy-and-femtosecond-laser-assisted-in-situ-keratomileusis
#12
Nauman Hashmani, Sharif Hashmani, Priyanka Ramesh, Hina Rajani, Junaid Ahmed, Jaish Kumar, Arun Kumar, Munira Jamali
Purpose To compare visual outcomes and satisfaction among patients of photorefractive keratectomy (PRK; Wavelight EX 500, Alcon, Ft Worth, TX, USA) and femtosecond laser-assisted in situ keratomileusis (FAL; Wavelight FS 200 laser and Wavelight EX 500, Alcon, Ft Worth, TX, USA). Methods We performed a retrospective study of 409 eyes in 207 patients that underwent either PRK (n=90) or FAL (n=117) at the two centers of Hashmanis Hospital, Karachi, Pakistan. The included refractive outcomes were sphere diopters (D), cylinder D, and spherical equivalent D...
September 1, 2017: Curēus
https://www.readbyqxmd.com/read/29082476/effective-utilization-of-carbohydrate-in-corncob-to-synthesize-furfuralcohol-by-chemical-enzymatic-catalysis-in-toluene-water-media
#13
Xin-Xia Xue, Jun-Hua Di, Yu-Cai He, Bing-Qian Wang, Cui-Luan Ma
In this study, carbohydrates (cellulose plus hemicellulose) in corncob were effectively converted furfuralcohol (FOL) via chemical-enzymatic catalysis in a one-pot manner. After corncob (2.5 g, dry weight) was pretreated with 0.5 wt% oxalic acid, the obtained corncob-derived xylose (19.8 g/L xylose) could be converted to furfural at 60.1% yield with solid acid catalyst SO4(2-)/SnO2-attapulgite (3.6 wt% catalyst loading) in the water-toluene (3:1, v/v) at 170 °C for 20 min. Moreover, the oxalic acid-pretreated corncob residue (1...
October 30, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29033165/molecular-epidemiological-study-of-familial-amyotrophic-lateral-sclerosis-in-japanese-population-by-whole-exome-sequencing-and-identification-of-novel-hnrnpa1-mutation
#14
Hiroya Naruse, Hiroyuki Ishiura, Jun Mitsui, Hidetoshi Date, Yuji Takahashi, Takashi Matsukawa, Masaki Tanaka, Akiko Ishii, Akira Tamaoka, Keiichi Hokkoku, Masahiro Sonoo, Mari Segawa, Yoshikazu Ugawa, Koichiro Doi, Jun Yoshimura, Shinichi Morishita, Jun Goto, Shoji Tsuji
To elucidate the genetic epidemiology of familial amyotrophic lateral sclerosis (FALS) in the Japanese population, we conducted whole-exome sequencing analysis of 30 FALS families in whom causative mutations have not been identified in previous studies. Consequently, whole-exome sequencing analysis revealed novel mutations in HNRNPA1, TBK1, and VCP. Taken together with our previous results of mutational analyses by direct nucleotide sequencing analysis, a microarray-based resequencing method, or repeat-primed PCR analysis, causative mutations were identified in 41 of the 68 families (60...
September 6, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28993872/a-novel-mutation-of-vapb-in-one-chinese-familial-amyotrophic-lateral-sclerosis-pedigree-and-its-clinical-characteristics
#15
Yi-Min Sun, Yi Dong, Jian Wang, Jia-Hong Lu, Yan Chen, Jian-Jun Wu
The mutation of vesicle-associated membrane protein-associated protein B (VAPB) was proved to cause family amyotrophic lateral sclerosis (FALS). Only two mutations of VAPB associated with ALS have been reported (p.Pro56Ser and p.Thr46Ile). Here we reported a Chinese Han FALS family caused by a novel VAPB point mutation. The clinical materials of one Chinese Han FALS family were collected. The genetic analysis was carried out by target sequencing and further verified by Sanger sequencing. One novel mutation of c...
December 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28982682/phyllotactic-regularity-requires-the-paf1-complex-in-arabidopsis
#16
Kateryna Fal, Mengying Liu, Assem Duisembekova, Yassin Refahi, Elizabeth S Haswell, Olivier Hamant
In plants, aerial organs are initiated at stereotyped intervals, both spatially (every 137 degrees in a pattern called phyllotaxis) and temporally (at prescribed time intervals called plastochron). To investigate the molecular basis of such regularity, mutants with altered architecture have been isolated. However, most of them only exhibit defects in plastochron and/or produce a new, albeit equally reproducible, phyllotactic pattern. This leaves open the question of a molecular control of phyllotaxis regularity...
October 5, 2017: Development
https://www.readbyqxmd.com/read/28979725/effect-of-nicorandil-on-qt-dispersion-in-patients-with-stable-angina-pectoris-undergoing-elective-angioplasty-a-triple-blind-randomized-placebo-controlled-study
#17
Homa Fal Suleimani, Ali Eshraghi, Mehdi Hasanzadeh Daloee, Sara Hoseini, Nima Nakhaee
BACKGROUND: Nicorandil leads to the relaxation of fine vascular smooth muscle, and thus causes vasodilatation of major epicardial. Also, it has anti-arrhythmic and cardio-protective effects by improving reperfusion, and ultimately leads to a reduction in microvascular damage caused by percutaneous coronary intervention (PCI). OBJECTIVE: The aim of this study was to determine the effect of nicorandil on QT interval dispersion (QTd) in patients with stable angina pectoris during elective angioplasty...
August 2017: Electronic Physician
https://www.readbyqxmd.com/read/28943780/strategies-for-the-construction-of-supramolecular-dimers-versus-homoleptic-1d-coordination-polymers-starting-from-the-diphosphorus-cp2mo2-co-4-%C3%AE-2-p2-complex-and-silver-i-salts
#18
Mehdi Elsayed Moussa, Martin Fleischmann, Eugenia V Peresypkina, Luis Dütsch, Michael Seidl, Gabor Balázs, Manfred Scheer
The reactions of the tetrahedral diphosphorus [Cp2Mo2(CO)4(η(2)-P2)] (1; Cp = C5H5) complex with Ag[Al{OC(CF3)3}4] (AgTEF) (A) and Ag[FAl{OC(C6F5)(C6F10)}3] (AgFAl) (B) were studied. The first reaction led to the formation of the [Ag2(η(2)-1)2(η(1):η(1)-1)2][TEF]2 (2) dimer and the [Ag2(η(1):η(1)-1)3] n [TEF]2n (3) coordination polymer, whereas the second reaction afforded the [Ag2(η(1):η(1)-1)2(η(1)-CH2Cl2)2(η(2)-C7H8)2][FAl]2 (4) or the [Ag2(η(2)-1)2(η(1):η(1)-1)2][FAl]2 (5) dimer and the [Ag2(η(1):η(1)-1)4] n [FAl]2n (6) coordination polymer...
July 7, 2017: European Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28899654/deciphering-the-loss-of-metal-binding-due-to-mutation-d83g-of-human-sod1-protein-causing-fals-disease
#19
E Srinivasan, R Rajasekaran
Mutations in Cu/Zn superoxide dismutase 1 (SOD1) protein are found to be the causative factor, behind the majority of familial amyotrophic later sclerosis (FALS) cases. The mutations particularly on the metal (Zn) binding residues are found to increase the disease onset in the individuals suffering from FALS, while the presence of the metal ion (Zn) is essential for the catalytic activity and retaining the protein stability. Thus in our study, we focused on one such metal binding mutant (D83G) and assessed the impact of the mutation on protein structure and function...
September 9, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28884318/implications-of-fals-mutations-on-sod1-function-and-oligomerization-in-cell-models
#20
Aline A Brasil, Rayne S S Magalhães, Mariana D C De Carvalho, Isabel Paiva, Ellen Gerhardt, Marcos D Pereira, Tiago F Outeiro, Elis C A Eleutherio
Among the familial forms of amyotrophic lateral sclerosis (fALS), 20% are associated with the Cu,Zn-superoxide dismutase (Sod1). fALS is characterized by the accumulation of aggregated proteins and the increase in oxidative stress markers. Here, we used the non-invasive bimolecular fluorescence complementation (BiFC) assay in human H4 cells to investigate the kinetics of aggregation and subcellular localization of Sod1 mutants. We also studied the effect of the different Sod1 mutants to respond against oxidative stress by following the levels of reactive oxygen species (ROS) after treatment with hydrogen peroxide...
September 7, 2017: Molecular Neurobiology
keyword
keyword
109491
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"