keyword
MENU ▼
Read by QxMD icon Read
search

anchored molecular

keyword
https://www.readbyqxmd.com/read/28932220/chalcone-attenuates-staphylococcus-aureus-virulence-by-targeting-sortase-a-and-alpha-hemolysin
#1
Bing Zhang, Zihao Teng, Xianhe Li, Gejin Lu, Xuming Deng, Xiaodi Niu, Jianfeng Wang
Staphylococcus aureus (S.aureus) resistance, considered a dilemma for the clinical treatment of this bacterial infection, is becoming increasingly intractable. Novel anti-virulence strategies will undoubtedly provide a path forward in combating these resistant bacterial infections. Sortase A (SrtA), an enzyme responsible for anchoring virulence-related surface proteins, and alpha-hemolysin (Hla), a pore-forming cytotoxin, have aroused great scientific interest, as they have been regarded as targets for promising agents against S...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28930097/dipole-switch-induced-modification-of-the-emissive-response-of-carbon-nanotubes
#2
Mareen Gläske, Pascal Bluemmel, Sabrina Juergensen, Antonio Setaro, Stephanie Reich
The interaction of carbon nanotubes with the molecular dipole switch spiropyran is expected to affect the optical response of the tubes. Until now, the need of anchor groups to immobilize the switches on the tubes has hindered experimental observation of effects of switching on the emission behavior of the tubes. Here we present spiropyran-carbon nanotubes complexes obtained by micelle swelling. This method does not require any anchor nor sophisticated chemistry to warrant close tube-switch proximity. For the first time we observe the shifts predicted theoretically and their effect on the tubes' excitation and emission energies...
September 20, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28926625/defining-the-molecular-basis-of-interaction-between-r3-receptor-type-protein-tyrosine-phosphatases-and-ve-cadherin
#3
Olga Dorofejeva, Alastair J Barr
Receptor-type protein tyrosine phosphatases (RPTPs) of the R3 subgroup play key roles in the immune, vascular and nervous systems. They are characterised by a large ectodomain comprising multiple FNIII-like repeats, a transmembrane domain, and a single intracellular phosphatase domain. The functional role of the extracellular region has not been clearly defined and potential roles in ligand interaction, dimerization, and regulation of cell-cell contacts have been reported. Here bimolecular fluorescence complementation (BiFC) in live cells was used to examine the molecular basis for the interaction of VE-PTP with VE-cadherin, two proteins involved in endothelial cell contact and maintenance of vascular integrity...
2017: PloS One
https://www.readbyqxmd.com/read/28912108/leptospira-borgpetersenii-hybrid-leucine-rich-repeat-protein-cloning-and-expression-immunogenic-identification-and-molecular-docking-evaluation
#4
Tepyuda Sritrakul, Supachai Nitipan, Worawidh Wajjwalku, Anchalee La-Ard, Chattip Suphatpahirapol, Wimol Petkarnjanapong, Boonsong Ongphiphadhanakul, Siriwan Prapong
Leptospirosis is an important zoonotic disease, and the major outbreak of this disease in Thailand in 1999 was due largely to the Leptospira borgpetersenii serovar Sejroe. Identification of the leucine-rich repeat (LRR) LBJ_2271 protein containing immunogenic epitopes and the discovery of the LBJ_2271 ortholog in Leptospira serovar Sejroe, KU_Sej_R21_2271, led to further studies of the antigenic immune properties of KU_Sej_LRR_2271. The recombinant hybrid (rh) protein was created and expressed from a hybrid PCR fragment of KU_Sej_R21_2271 fused with DNA encoding the LBJ_2271 signal sequence for targeting protein as a membrane-anchoring protein...
September 12, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28904612/block-copolymers-from-ionic-liquids-for-the-preparation-of-thin-carbonaceous-shells
#5
Sadaf Hanif, Bernd Oschmann, Dmitri Spetter, Muhammad Nawaz Tahir, Wolfgang Tremel, Rudolf Zentel
This paper describes the controlled radical polymerization of an ionic-liquid monomer by RAFT polymerization. This allows the control over the molecular weight of ionic liquid blocks in the range of 8000 and 22000 and of the block-copolymer synthesis. In this work we focus on block copolymers with an anchor block. They can be used to control the formation of TiO2 nanoparticles, which are functionalized thereafter with a block of ionic-liquid polymer. Pyrolysis of these polymer functionalized inorganic nanoparticles leads to TiO2 nanoparticles coated with a thin carbonaceous shell...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28901494/molecular-mechanisms-of-pathogenesis-in-hepatocellular-carcinoma-revealed-by-rna%C3%A2-sequencing
#6
Yao Liu, Zhe Yang, Feng Du, Qiao Yang, Jie Hou, Xiaohong Yan, Yi Geng, Yaning Zhao, Hua Wang
The present study aimed to explore the underlying molecular mechanisms of hepatocellular carcinoma (HCC). RNA‑sequencing profiles GSM629264 and GSM629265, from the GSE25599 data set, were downloaded from the Gene Expression Omnibus database and processed by quality evaluation. GSM629264 and GSM629265 were from HCC and adjacent non‑cancerous tissues, respectively. TopHat software was used for alignment analysis, followed by the detection of novel splicing sites. In addition, the Cufflinks software package was used to analyze gene expressions, and the Cuffdiff program was used to screen for differently expressed genes (DEGs) and differentially expressed splicing variants...
September 11, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28899095/nanodrops-of-discotic-liquid-crystals-a-monte-carlo-study
#7
Luis F Rull, José Manuel Manuel Romero-Enrique
We study the morphologies of nematic nanodrops in a vapor of a discotic nematogen by Monte Carlo simulations. The fluid interactions are modeled by a Gay-Berne model with molecular elongations κ=0.3 and 0.5, and different values of the energy anisotropy parameter κ' in the range of temperatures T in which the nematic coexists with a vapor phase. We considered nanodrops of N=4000 and N=32000 particles. For κ>κ' we observe that nanodrops are quite spherical (even for N=4000 nanodrops), with a homogeneous director field for κ=0...
September 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28893534/solution-structure-of-the-n-terminal-domain-of-mediator-subunit-med26-and-molecular-characterization-of-its-interaction-with-eaf1-and-taf7
#8
Zoé Lens, François-Xavier Cantrelle, Riccardo Peruzzini, Xavier Hanoulle, Frédérique Dewitte, Elisabeth Ferreira, Jean-Luc Baert, Didier Monté, Marc Aumercier, Vincent Villeret, Alexis Verger, Isabelle Landrieu
MED26 is a subunit of Mediator, a large complex central to the regulation of gene transcription by RNA Polymerase II. MED26 plays a role in the switch between the initiation and elongation phases of RNA Polymerase II-mediated transcription process. Regulation of these steps requires successive binding of MED26 N-terminal domain (NTD) to TATA-binding protein-associated factor 7 (TAF7) and Eleven-nineteen lysine-rich in leukemia-Associated Factor 1 (EAF1). In order to investigate the mechanism of regulation by MED26, MED26-NTD structure was solved by NMR, revealing a 4-helix bundle...
September 9, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28891023/variation-of-mucin-adhesion-cell-surface-characteristics-and-molecular-mechanisms-among-lactobacillus-plantarum-isolated-from-different-habitats
#9
Nirunya Buntin, Willem M de Vos, Tipparat Hongpattarakere
The adhesion ability to mucin varied greatly among 18 Lactobacillus plantarum isolates depending on their isolation habitats. Such ability remained at high level even though they were sequentially exposed to the gastrointestinal (GI) stresses. The majority of L. plantarum isolated from shrimp intestine and about half of food isolates exhibited adhesion ability (51.06-55.04%) about the same as the well-known adhesive L. plantarum 299v. Interestingly, five infant isolates of CIF17A2, CIF17A4, CIF17A5, CIF17AN2, and CIF17AN8 exhibited extremely high adhesion ranging from 62...
September 11, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28888050/significance-of-perivascular-tumour-cells-defined-by-cd109-expression-in-progression-of-glioma
#10
Yukihiro Shiraki, Shinji Mii, Atsushi Enomoto, Hiroyuki Momota, Yi-Peng Han, Takuya Kato, Kaori Ushida, Akira Kato, Naoya Asai, Yoshiki Murakumo, Kosuke Aoki, Hiromichi Suzuki, Fumiharu Ohka, Toshihiko Wakabayashi, Tomoki Todo, Seishi Ogawa, Atsushi Natsume, Masahide Takahashi
In the progression of glioma, tumour cells often exploit the perivascular microenvironment to promote their survival and resistance to conventional therapies. Some of these cells are considered to be brain tumour stem cells (BTSCs); however, the molecular nature of perivascular tumour cells has not been specifically clarified because of the complexity of glioma. Here, we identified CD109, a glycosylphosphatidylinositol- anchored protein and regulator of multiple signalling pathways, as a critical regulator of the progression of lower-grade glioma (World Health Organization grade II/III) by clinicopathological and whole genome sequencing analysis of tissues from human glioma...
September 9, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28885841/tuning-product-selectivity-for-aqueous-co2-reduction-with-a-mn-bipyridine-pyrene-catalyst-immobilized-on-a-carbon-nanotube-electrode
#11
Bertrand Reuillard, Khoa H Ly, Timothy E Rosser, Moritz F Kuehnel, Ingo Zebger, Erwin Reisner
The development of high-performance electrocatalytic systems for the controlled reduction of CO2 to value-added chemicals is a key goal in emerging renewable energy technologies. The lack of selective and scalable catalysts in aqueous solution currently hampers the implementation of such a process. Here, the assembly of a [MnBr(2,2'-bipyridine)(CO)3] complex anchored to a carbon nanotube electrode via a pyrene unit is reported. Immobilization of the molecular catalyst allows electrocatalytic reduction of CO2 under fully aqueous conditions with a catalytic onset overpotential η = 360 mV and controlled potential electrolysis generated more than a thousand turnovers at η = 550 mV...
September 8, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28885759/host-guest-complexes-of-cyclodextrins-and-nanodiamonds-as-strong-non-covalent-binding-motif-for-self-assembled-nanomaterials
#12
Frauke Schibilla, Jens Voskuhl, Natalie Fokina, Jeremy Dahl, Peter R Schreiner, Bart Jan Ravoo
We report on the inclusion of carboxy- and amine-substituted molecular nanodiamonds (NDs) adamantane, diamantane and triamantane by β- and γ-cyclodextrin (β-CD and γ-CD) with particularly suited hydrophobicity and symmetry for an optimal fit of host and guest. We studied the host-guest interactions in detail and generally observed 1:1 association of the NDs with the larger γ-CD cavity but 1:2 association for the largest ND in the series (triamantane) with β-CD. We found higher binding affinities of carboxy-substituted NDs compared to amine-substituted NDs...
September 8, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28881798/role-of-a-kinase-anchor-protein-akap4-in-growth-and-survival-of-ovarian-cancer-cells
#13
Vikash Kumar, Nirmala Jagadish, Anil Suri
Ovarian cancer represents one of the most common malignancies among women with very high mortality rate worldwide. A-kinase anchor protein 4 (AKAP4), a unique cancer testis (CT) antigen has been shown to be associated with various malignant properties of cancer cells. However, its involvement in various molecular pathways in ovarian cancer remains unknown. In present investigation, employing gene silencing approach, we examined the role of AKAP4 in cell cycle, apoptosis and epithelial-mesenchymal transition (EMT)...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28880279/live-cell-confocal-microscopy-and-quantitative-4d-image-analysis-of-anchor-cell-invasion-through-the-basement-membrane-in-caenorhabditis-elegans
#14
Laura C Kelley, Zheng Wang, Elliott J Hagedorn, Lin Wang, Wanqing Shen, Shijun Lei, Sam A Johnson, David R Sherwood
Cell invasion through basement membrane (BM) barriers is crucial in development, leukocyte trafficking and the spread of cancer. The mechanisms that direct invasion, despite their importance in normal and disease states, are poorly understood, largely because of the inability to visualize dynamic cell-BM interactions in vivo. This protocol describes multichannel time-lapse confocal imaging of anchor-cell invasion in live Caenorhabditis elegans. Methods presented include outline-slide preparation and worm growth synchronization (15 min), mounting (20 min), image acquisition (20-180 min), image processing (20 min) and quantitative analysis (variable timing)...
October 2017: Nature Protocols
https://www.readbyqxmd.com/read/28876352/nanostructured-interfacial-self-assembled-peptide-polymer-membranes-for-enhanced-mineralization-and-cell-adhesion
#15
Sofia Ribeiro, Elham Radvar, Yejiao Shi, João Borges, Rogério P Pirraco, Isabel B Leonor, João F Mano, Rui L Reis, Álvaro Mata, Helena S Azevedo
Soft interfacial materials, such as self-assembled polymer membranes, are gaining increasing interest as biomaterials since they can provide selective barriers and/or controlled affinity interactions important to regulate cellular processes. Herein, we report the design and fabrication of multiscale structured membranes integrating selective molecular functionalities for potential applications in bone regeneration. The membranes were obtained by interfacial self-assembly of miscible aqueous solutions of hyaluronan and multi-domain peptides (MDPs) incorporating distinct biochemical motifs, including mineralizing (EE), integrin-binding (RGDS) and osteogenic (YGFGG) peptide sequences...
September 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28876015/molecular-attochemistry-in-non-polar-liquid-environments-ultrafast-charge-migration-dynamics-through-gold-thiolate-and-gold-selenolate-linkages
#16
Sampad Bag, Sankhabrata Chandra, Atanu Bhattacharya
Molecular attosecond science has already started contributing to our fundamental understanding of ultrafast purely electron dynamics in isolated molecules under vacuum. Extending attosecond science to the liquid phase is expected to offer new insight into the influence of a surrounding solvent environment on the attosecond electron dynamics in solvated molecules. A systematic theoretical investigation of the attochemistry of solvated molecules would help one design attosecond experiments under ambient conditions to explore the attochemistry in a liquid environment...
September 6, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28875434/nonlinear-and-nonsymmetric-single-molecule-electronic-properties-towards-molecular-information-processing
#17
REVIEW
Takashi Tamaki, Takuji Ogawa
This review highlights molecular design for nonlinear and nonsymmetric single-molecule electronic properties such as rectification, negative differential resistance, and switching, which are important components of future single-molecule information processing devices. Perspectives on integrated "molecular circuits" are also provided. Nonlinear and nonsymmetric single-molecule electronics can be designed by utilizing (1) asymmetric molecular cores, (2) asymmetric anchoring groups, (3) an asymmetric junction environment, and (4) asymmetric electrode materials...
September 5, 2017: Topics in Current Chemistry (Journal)
https://www.readbyqxmd.com/read/28871634/assembly-and-analysis-of-a-qingke-reference-genome-demonstrates-its-close-genetic-relation-to-modern-cultivated-barley
#18
Fei Dai, Xiaolei Wang, Xiao-Qi Zhang, Zhonghua Chen, Eviatar Nevo, Gulei Jin, Dezhi Wu, Chengdao Li, Guoping Zhang
Qingke, the local name of hulless barley in the Tibetan Plateau, is a staple food for Tibetans. The availability of its reference genome sequences could be useful for studies on breeding and molecular evolution. Taking advantage of the third-generation sequencer (PacBio), we de novo assembled a 4.84 Gb genome sequence of qingke, cv. Zangqing320 and anchored a 4.59 Gb sequence to seven chromosomes. Of the 46,787 annotated 'high-confidence' genes, 31,564 were validated by RNA-sequencing data of 39 wild and cultivated barley genotypes with wide genetic diversity, and the results were also confirmed by non-redundant protein database from NCBI...
September 4, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28868340/e-selectin-and-sdf-1-regulate-metastatic-trafficking-of-breast-cancer-cells-within-the-bone
#19
Trevor T Price, Dorothy A Sipkins
E-selectin is a key mediator of breast cancer cell (BCC) metastatic entry into the bone and stromal-derived factor 1 (SDF-1) is a critical molecular anchor for BCCs within discrete pro-dormancy bone marrow (BM) niches. Small-molecule inhibitors blocked metastatic entry and mobilized established disease from BM, suggesting a new treatment strategy to prevent breast cancer relapse.
2017: Molecular & Cellular Oncology
https://www.readbyqxmd.com/read/28864445/dissection-of-the-molecular-circuitry-controlling-virulence-in-francisella-tularensis
#20
Bonnie J Cuthbert, Wilma Ross, Amy E Rohlfing, Simon L Dove, Richard L Gourse, Richard G Brennan, Maria A Schumacher
Francisella tularensis, the etiological agent of tularemia, is one of the most infectious bacteria known. Because of its extreme pathogenicity, F. tularensis is classified as a category A bioweapon by the US government. F. tularensis virulence stems from genes encoded on the Francisella pathogenicity island (FPI). An unusual set of Francisella regulators-the heteromeric macrophage growth locus protein A (MglA)-stringent starvation protein A (SspA) complex and the DNA-binding protein pathogenicity island gene regulator (PigR)-activates FPI transcription and thus is essential for virulence...
September 1, 2017: Genes & Development
keyword
keyword
109489
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"