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https://www.readbyqxmd.com/read/28214340/molecular-tiling-on-the-surface-of-a-bacterial-spore-the-exosporium-of-the-bacillus-anthracis-cereus-thuringiensis-group
#1
Cassandra Terry, Shuo Jiang, David S Radford, Wan Qiang, Svetomir Tzokov, Anne Moir, Per A Bullough
Bacteria of the genera Bacillus and Clostridium form highly resistant spores, which in the case of some pathogens act as the infectious agents. An exosporium forms the outermost layer of some spores; it plays roles in protection, adhesion, dissemination, host targeting in pathogens, and germination control. The exosporium of the Bacillus cereus group, including the anthrax pathogen, contains a 2D-crystalline basal layer, overlaid by a hairy nap. BclA and related proteins form the hairy nap, and require ExsFA (BxpB) for their localisation on the basal layer...
February 18, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28213174/evidence-of-the-presence-of-a-calmodulin-sensitive-plasma-membrane-ca-2-atpase-in-trypanosoma-equiperdum
#2
María Carolina Pérez-Gordones, José Rubén Ramírez-Iglesias, Vincenza Cervino, Graciela L Uzcanga, Gustavo Benaim, Marta Mendoza
Trypanosoma equiperdum belongs to the subgenus Trypanozoon, which has a significant socio-economic impact by limiting animal protein productivity worldwide. Proteins involved in the intracellular Ca(2+) regulation are prospective chemotherapeutic targets since several drugs used in experimental treatment against trypanosomatids exert their action through the disruption of the parasite intracellular Ca(2+) homeostasis. Therefore, the plasma membrane Ca(2+)-ATPase (PMCA) is considered as a potential drug target...
February 14, 2017: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/28213095/cytotoxicity-of-gold-nanoparticles-with-different-structures-and-surface-anchored-chiral-polymers
#3
Jun Deng, Mengyun Yao, Changyou Gao
Nanoparticles (NPs) can have profound effects on cell biology. However, the potential adverse effects of gold nanoparticles (AuNPs) with different surface chirality and structures have not been elucidated. In this study, monolayers of poly(acryloyl-L(D)-valine (L(D)-PAV) chiral molecules were anchored on the surfaces of gold nanocubes (AuNCs) and nanooctahedras (AuNOs), respectively. The L-PAV-AuNCs and D-PAV-AuNCs, or the L-PAV-AuNOs and D-PAV-AuNOs, had identical physicochemical properties in terms of size, morphology and ligand density except of the reverse molecular chirality on the particle surfaces, respectively...
February 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28210903/role-of-exchange-protein-directly-activated-by-camp-epac1-in-breast-cancer-cell-migration-and-apoptosis
#4
Naveen Kumar, Sonal Gupta, Surbhi Dabral, Shailja Singh, Seema Sehrawat
Despite the current progress in cancer research and therapy, breast cancer remains the leading cause of mortality among half a million women worldwide. Migration and invasion of cancer cells are associated with prevalent tumor metastasis as well as high mortality. Extensive studies have powerfully established the role of prototypic second messenger cAMP and its two ubiquitously expressed intracellular cAMP receptors namely the classic protein kinaseA/cAMP-dependent protein kinase (PKA) and the more recently discovered exchange protein directly activated by cAMP/cAMP-regulated guanine nucleotide exchange factor (EPAC/cAMP-GEF) in cell migration, cell cycle regulation, and cell death...
February 16, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28208449/anisotropic-charge-transport-in-ion-conductive-photoresponsive-polyethylene-oxide-based-mesomorphic-materials
#5
Corinne Binet, Alexandre Allart, Patrick Judeinstein, Frédérick Roussel
The mechanism of charge motion in conductive and photosensitive mesogenic block copolymers containing polyethylene oxide (PEO) segments is investigated over a wide frequency and temperature range with the broadband dielectric spectroscopy technique. It is found that the ultraviolet (UV) irradiation, the UV intensity, and the anchoring conditions of mesogenic unit in the cells produce changes in conductivity properties and in the molecular arrangement. The anisotropic nature of the conductivity is established...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28208081/molecular-synergy-in-biolubrication-the-role-of-cartilage-oligomeric-matrix-protein-comp-in-surface-structuring-of-lubricin
#6
Akanksha Raj, Min Wang, Chao Liu, Liaquat Ali, Niclas G Karlsson, Per M Claesson, Andra Dėdinaitė
HYPOTHESIS: Synovial surfaces are lubricated by biomolecular aggregates that act in synergy, and lubricin is one key biolubricant. Its molecular structure allows extensive hydration and this is conducive to its lubrication performance. However, in order to fullfil its lubrication function it needs to be anchored and oriented on the surface in a proper way. We suggest that cartilage oligomeric matrix protein (COMP) is one of the biomolecules that promotes anchoring of lubricin in a fashion that facilitates lubrication...
February 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28205437/surface-and-interface-engineering-of-noble-metal-free-electrocatalysts-for-efficient-energy-conversion-processes
#7
Yun Pei Zhu, Chunxian Guo, Yao Zheng, Shi-Zhang Qiao
Developing cost-effective and high-performance electrocatalysts for renewable energy conversion and storage is motivated by increasing concerns regarding global energy security and creating sustainable technologies dependent on inexpensive and abundant resources. Recent achievements in the design and synthesis of efficient non-precious-metal and even non-metal electrocatalysts make the replacement of noble metal counterparts for the hydrogen evolution reaction (HER), oxygen evolution reaction (OER), and oxygen reduction reaction (ORR) with earth-abundant elements, for example, C, N, Fe, Mn, and Co, a realistic possibility...
February 16, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28201988/molecular-characterization-of-mhc-class-iib-genes-of-sympatric-neotropical-cichlids
#8
Melinda J Hofmann, Seraina E Bracamonte, Christophe Eizaguirre, Marta Barluenga
BACKGROUND: The Major Histocompatibility Complex (MHC) is a key component of the adaptive immune system of all vertebrates and consists of the most polymorphic genes known to date. Due to this complexity, however, MHC remains to be characterized in many species including any Neotropical cichlid fish. Neotropical crater lake cichlids are ideal models to study evolutionary processes as they display one of the most convincing examples of sympatric and repeated parallel radiation events within and among isolated crater lakes...
February 15, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28201879/full-dimensional-ground-and-excited-state-potential-energy-surfaces-and-state-couplings-for-photodissociation-of-thioanisole
#9
Shaohong L Li, Donald G Truhlar
Analytic potential energy surfaces (PESs) and state couplings of the ground and two lowest singlet excited states of thioanisole (C6H5SCH3) are constructed in a diabatic representation based on electronic structure calculations including dynamic correlation. They cover all 42 internal degrees of freedom and a wide range of geometries including the Franck-Condon region and the reaction valley along the breaking S-CH3 bond with the full ranges of the torsion angles. The parameters in the PESs and couplings are fitted to the results of smooth diabatic electronic structure calculations including dynamic electron correlation by the extended multi-configurational quasi-degenerate perturbation theory method for the adiabatic state energies followed by diabatization by the fourfold way...
February 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28198505/migration-and-invasion-enhancer-1-mien1-is-overexpressed-in-breast-cancer-and-is-a-potential-new-therapeutic-molecular-target
#10
H-B Zhao, X-F Zhang, H-B Wang, M-Z Zhang
Migration and invasion enhancer 1 (MIEN1) is a membrane-anchored protein that is highly expressed in various types of cancer, and is correlated with the PI3K/AKT pathway. The aim of this study was to investigate the expression of MIEN1 and its clinical pathological significance in breast cancer. We used immunohistochemical staining to examine the expression of MIEN1 in 40 samples of human breast cancer tissue and 10 samples taken from regions adjacent to normal breast tissue. The rate of detection of MIEN1 protein was 67...
February 8, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28198374/magnetic-routing-of-light-induced-waveguides
#11
Yana Izdebskaya, Vladlen Shvedov, Gaetano Assanto, Wieslaw Krolikowski
Among photofunctional materials that can be employed to control the propagation of light by modifying their properties, soft dielectrics such as nematic liquid crystals (NLCs) stand out for their large all-optical response. Through reorientation, the molecular distribution of NLCs can be modified by the electric field of light, permitting functional operations and supporting self-localized light beams or spatial optical solitons. To date, the generation and routing of such solitons have been limited by the boundary conditions employed to tailor the properties of NLCs in planar cells or capillaries...
February 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28198353/adsorption-and-migration-of-single-metal-atoms-on-the-calcite-10-4-surface
#12
H Pinto, V Haapasilta, M Lokhandwala, S Öberg, Adam S Foster
Transition metal atoms are one of the key ingredients in the formation of functional 2D metal organic coordination networks. Additionally, the co-deposition of metal atoms can play an important role in anchoring the molecular structures to the surface at room temperature. To gain control of such processes requires the understanding of adsorption and diffusion properties of the different transition metals on the target surface. Here, we used density functional theory to investigate the adsorption of 3d (Ti, Cr, Fe, Ni, Cu), 4d (Zr, Nb, Mo, Pd, Ag) and 5d (Hf, W, Ir, Pt, Au) transition metal adatoms on the insulating calcite (10...
February 15, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28196861/molecular-determinants-of-the-n-terminal-acetyltransferase-naa60-anchoring-to-the-golgi-membrane
#13
Henriette Aksnes, Marianne Goris, Øyvind Strømland, Adrian Drazic, Qaiser Waheed, Nathalie Reuter, Thomas Arnesen
Nα-acetyltransferase 60 (Naa60 or NatF) was recently identified as an unconventional N-terminal acetyltransferase (NAT) since it localizes to organelles, in particular the Golgi apparatus, and has a preference for acetylating N-termini of transmembrane proteins. This knowledge challenged the prevailing view of N-terminal acetylation as a co-translational ribosome-associated process and suggested a new mechanistic functioning for the enzymes responsible for this increasingly recognized protein modification...
February 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28192645/cytological-molecular-and-clinical-features-of-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-versus-invasive-forms-of-follicular-variant-of-papillary-thyroid-carcinoma
#14
Liena Zhao, Dora Dias-Santagata, Peter M Sadow, William C Faquin
BACKGROUND: The noninvasive follicular variant of papillary thyroid carcinoma (PTC) has an indolent clinical behavior in comparison with other PTCs, including the invasive follicular variant of papillary thyroid carcinoma (IFVPTC). Recently, the term noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was introduced to emphasize the low biological potential of these tumors. This study compares clinical, cytological, and molecular features of NIFTP and IFVPTC...
February 13, 2017: Cancer
https://www.readbyqxmd.com/read/28192241/molecular-cloning-mrna-expression-and-characterization-of-membrane-bound-hemoglobin-in-oriental-river-prawn-macrobrachium-nipponense
#15
Shengming Sun, Fujun Xuan, Hongtuo Fu, Jian Zhu, Xianping Ge, Xugan Wu
Most hemoglobins are respiratory proteins and are ubiquitous in animals, bacteria, fungi, protists, and plants. In this study, we describe a membrane-bound hemoglobin in the oriental river prawn Macrobrachium nipponense (MnHb), which also expresses hemocyanin. MnHb cDNA was cloned using the rapid amplification of cDNA ends (RACE) approach, which afforded a 1201bp gene encoding a 193 amino acid polypeptide. Bioinformatic evaluation suggested MnHb is membrane anchored by N-myristoylation, and immunofluorescence confirmed its location in the membrane of chief cells in the gill...
February 10, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28191961/poly-glycidyl-ether-based-monolayers-on-gold-surfaces-control-of-grafting-density-and-chain-conformation-by-grafting-procedure-surface-anchor-and-molecular-weight
#16
Silke Heinen, Marie Weinhart
For a meaningful correlation of surface coatings with their respective biological response reproducible coating procedures, well-defined surface coatings, and thorough surface characterization with respect to layer thickness and grafting density are indispensable. The same applies to polymeric monolayer coatings which are intended to be used for, e.g., fundamental studies on the volume phase transition of surface end-tethered thermoresponsive polymer chains. Planar gold surfaces are frequently used as model substrates, since they allow a variety of straightforward surface characterization methods...
February 13, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28186746/unearthing-a-well-defined-highly-active-bimetallic-w-ti-pre-catalyst-anchored-on-a-single-silica-surface-for-metathesis-of-propane
#17
Manoja K Samantaray, Santosh Kavitake, Natalia Morlanes, Edy Abou-Hamad, Ali Hamieh, Raju Dey, Jean Marie Basset
Two compatible organometallic complexes, W(CH3)6 (1) followed by TiNp4 (2) were anchored on a highly dehydrox-ylated single silica support (silica-700) to synthesize a well-defined, bimetallic pre-catalyst [(≡Si-O-)W(Me)5 (≡Si-O-)Ti(Np)3](4). The pre-catalyst 4 was characterized at molecular level using advanced SOMC characterization tech-niques. Strong autocorrelation observed between methyl of W and Ti in 1H-1H Multiple Quantum NMR demonstrates that W and Ti species are in close proximity to each other...
February 10, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28186724/the-effect-of-heterocyclic-anchoring-sequence-on-the-properties-of-dithienogermole-based-solar-cells
#18
Bright Walker, Daehee Han, Mijin Moon, Song Yi Park, Ka-Hyun Kim, Jin Young Kim, Changduk Yang
The synthesis and characterization of two new small molecular donor materials, DTGe(ThFBTTh2)2 and DTGe(FBTTh3)2 are presented for application in organic solar cells. These two materials represent structural evolutions of the high-efficiency, dithienogermole (DTGe)-cored small molecule DTGe(FBTTh2)2, in which the conjugation length in the backbone was extended by incorporating additional thiophene units. Using the same molecular framework, we have evaluated how the anchoring sequence of heterocyclic units influences material properties and function in solar cell devices...
February 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28185454/starburst-triarylamine-donor-based-metal-free-photosensitizers-for-photocatalytic-hydrogen-production-from-water
#19
Po-Yu Ho, Yi Wang, Sze-Chun Yiu, Wai-Hong Yu, Cheuk-Lam Ho, Shuping Huang
Three metal-free molecular photosensitizers (S1-S3) featuring a starburst triarylamine donor moiety have been synthesized. They show attractive photocatalytic performance in visible light-driven H2 production from water in their platinized TiO2 composites. A remarkable H2 turnover number (TON) of 10 200 (48 h) was achieved in an S1-anchored system.
February 10, 2017: Organic Letters
https://www.readbyqxmd.com/read/28181015/a-density-functional-theory-investigation-of-the-interaction-of-the-tetraaqua-calcium-cation-with-bidentate-carbonyl-ligands
#20
Daniel Garcez S Quattrociocchi, Marcos Vinicius Monsores Meuser, Glaucio Braga Ferreira, José Walkimar de M Carneiro, Stanislav R Stoyanov, Leonardo Moreira da Costa
Calcium complexes with bidentate carbonyl ligands are important in biological systems, medicine and industry, where the concentration of Ca(2+) is controlled using chelating ligands. The exchange of two water molecules of [Ca(H2O)6](2+) for one bidentate monosubstituted and homo disubstituted dicarbonyl ligand was investigated using the B3LYP/6-311++G(d,p) method. The ligand substituents NH2, OCH3, OH, CH3, H, F, Cl, CN and NO2 are functional groups with distinct electron-donating and -withdrawing effects that bond directly to the sp(2) C atom of the carbonyl group...
February 2017: Journal of Molecular Modeling
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