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https://www.readbyqxmd.com/read/30648506/photopolymerizable-resins-for-3d-printing-solid-cured-tissue-engineered-implants
#1
Antonio J Guerra, Hernan Lara-Padilla, Luiz H Catalani, Matthew L Becker, Ciro A Rodriguez, David Dean
With the advent of inexpensive and highly accurate 3D printing devices, a tremendous flurry of research activity has been unleashed into new resorbable, polymeric materials that can be printed using three approaches: hydrogels for bioprinting and bioplotting, sintered polymer powders, and solid cured (photocrosslinked) resins. Additionally, there is a race to understand the role of extracellular matrix components and cell signaling molecules and to fashion ways to incorporate these materials into resorbable implants...
January 14, 2019: Current Drug Targets
https://www.readbyqxmd.com/read/30644290/animal-models-for-cartilage-repair
#2
I Tessaro, V T Nguyen, A Di Giancamillo, M Agnoletto, F Verdoni, M Domenicucci, R Scurati, G M Peretti, L Mangiavini
Cartilage lesions still represent an unsolved problem: despite the efforts of the basic and translational research, the regeneration of this tissue is far from being reached (1-3). Articular cartilage lesions can be divided in two main groups: superficial or partial defects and full-thickness defects (4, 5). Partial lesions are not able to self-heal because multipotent cells from the bone marrow cannot reach the area leading to a progressive degeneration of the tissue (6). Conversely, full-thickness injuries possess greater chances to heal because subchondral bone involvement allows for the migration of mesenchymal cells, which fill the damaged area (7, 8)...
November 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/30643508/diagnosis-and-treatment-of-the-nutcracker-syndrome-a-review-of-the-last-10-years
#3
REVIEW
Guilherme Lourenço de Macedo, Matheus Alves Dos Santos, Andrey Biff Sarris, Ricardo Zanetti Gomes
The nutcracker syndrome is characterized by a group of clinical manifestations caused by compression of the Left Renal Vein. The main symptoms are: macro and micro hematuria, proteinuria, and flank pain. Diagnosis is usually made after excluding other causes, because there are no clinical criteria for diagnosis. Confirmation is by Doppler ultrasonography or computed tomography. Treatment can vary, depending on patient characteristics and the severity of the symptoms, while conservative treatment, open surgery, and endovascular surgery may be employed...
July 2018: Jornal Vascular Brasileiro
https://www.readbyqxmd.com/read/30637857/advanced-pulmonary-mri-to-quantify-alveolar-and-acinar-duct-abnormalities-current-status-and-future-clinical-applications
#4
REVIEW
Andrew Westcott, David G McCormack, Grace Parraga, Alexei Ouriadov
There are serious clinical gaps in our understanding of chronic lung disease that require novel, sensitive, and noninvasive in vivo measurements of the lung parenchyma to measure disease pathogenesis and progressive changes over time as well as response to treatment. Until recently, our knowledge and appreciation of the tissue changes that accompany lung disease has depended on ex vivo biopsy and concomitant histological and stereological measurements. These measurements have revealed the underlying pathologies that drive lung disease and have provided important observations about airway occlusion, obliteration of the terminal bronchioles and airspace enlargement, or fibrosis and their roles in disease initiation and progression...
January 13, 2019: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/30622684/cardiac-implications-of-thrombotic-thrombocytopenic-purpura
#5
REVIEW
Szymon L Wiernek, Bo Jiang, Gregory M Gustafson, Xuming Dai
Thrombotic thrombocytopenic purpura (TTP) is a multisystem disorder that essentially can affect any organ in the human body. The hallmark of the pathogenesis in TTP is the large von Willebrand factor multimers on platelet-mediated micro-thrombi formation, leading to microvascular thrombosis. Autopsy studies showed that cardiac arrest and myocardial infarction are the most common immediate causes of death in these patients. Clinical manifestations of cardiac involvement in TTP vary dramatically, from asymptomatic elevation of cardiac biomarkers, to heart failure, MI and sudden cardiac death...
December 26, 2018: World Journal of Cardiology
https://www.readbyqxmd.com/read/30621068/restoring-dystrophin-expression-in-duchenne-muscular-dystrophy-current-status-of-therapeutic-approaches
#6
REVIEW
Yuko Shimizu-Motohashi, Hirofumi Komaki, Norio Motohashi, Shin'ichi Takeda, Toshifumi Yokota, Yoshitsugu Aoki
Duchenne muscular dystrophy (DMD), a rare genetic disorder characterized by progressive muscle weakness, is caused by the absence or a decreased amount of the muscle cytoskeletal protein dystrophin. Currently, several therapeutic approaches to cure DMD are being investigated, which can be categorized into two groups: therapies that aim to restore dystrophin expression, and those that aim to compensate for the lack of dystrophin. Therapies that restore dystrophin expression include read-through therapy, exon skipping, vector-mediated gene therapy, and cell therapy...
January 7, 2019: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/30609022/extracellular-micro-nanovesicles-rescue-kidney-from-ischemia-reperfusion-injury
#7
REVIEW
Saeed Farzamfar, Akram Hasanpour, Niloufar Nazeri, Hengameh Razavi, Majid Salehi, Shilan Shafei, Vajiheh T Nooshabadi, Ahmad Vaez, Arian Ehterami, Hamed Sahrapeyma, Jafar Ai
Acute renal failure (ARF) is a clinical challenge that is highly resistant to treatment, and its high rate of mortality is alarming. Ischemia-reperfusion injury (IRI) is the most common cause of ARF. Especially IRI is implicated in kidney transplantation and can determine graft survival. Although the exact pathophysiology of renal IRI is unknown, the role of inflammatory responses has been elucidated. Because mesenchymal stromal cells (MSCs) have strong immunomodulatory properties, they are under extensive investigation as a therapeutic modality for renal IRI...
January 4, 2019: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30605737/advanced-drug-delivery-systems-and-artificial-skin-grafts-for-skin-wound-healing
#8
REVIEW
Hye Sung Kim, Xiaoyan Sun, Jung-Hwan Lee, Hae-Won Kim, Xiaobing Fu, Kam W Leong
Cutaneous injuries, especially chronic wounds, burns, and skin wound infection, require painstakingly long-term treatment with an immense financial burden to healthcare systems worldwide. However, clinical management of chronic wounds remains unsatisfactory in many cases. Various strategies including growth factor and gene delivery as well as cell therapy have been used to enhance the healing of non-healing wounds. Drug delivery systems across the nano, micro, and macroscales can extend half-life, improve bioavailability, optimize pharmacokinetics, and decrease dosing frequency of drugs and genes...
December 31, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/30603120/combination-immunotherapy-and-radiation-therapy-strategies-for-pancreatic-cancer-targeting-multiple-steps-in-the-cancer-immunity-cycle
#9
REVIEW
Snehal Gajiwala, Anna Torgeson, Ignacio Garrido-Laguna, Conan Kinsey, Shane Lloyd
Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease, with its mortality rate approaching its incidence rate every year. Accordingly, much interest has been generated in harnessing the immune system in order to improve survival outcomes for these patients. Pancreatic cancer is not thought to be as immunogenic as other cancers that have seen promising results with immune checkpoint inhibitors alone, therefore likely several targets within the cancer-immunity cycle will need to be employed for successful treatment...
December 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30596534/laminar-air-flow-handling-systems-in-the-operating-room
#10
Sameer Jain, Mike Reed
BACKGROUND: Surgical site infection is associated with a substantial healthcare burden and remains one of the most challenging complications to treat. Airborne particles carrying contaminating micro-organisms are responsible for the majority of these infections. METHODS: Various operating theater ventilatory systems have been developed to prevent direct airborne bacterial inoculation of the surgical wound. Laminar air flow uses positive pressure air currents through filtration units to direct air streams away from the operative field in order to create an ultraclean zone around the operative site...
December 31, 2018: Surgical Infections
https://www.readbyqxmd.com/read/30587496/the-functional-role-of-prostate-cancer-metastasis-related-micro-rnas
#11
REVIEW
Ulrich H Weidle, Alexandra Epp, Fabian Birzele, Ulrich Brinkmann
The mortality of patients with hormone-resistant prostate cancer can be ascribed to a large degree to metastasis to distant organs, predominantly to the bones. In this review, we discuss the contribution of micro-RNAs (miRs) to the metastatic process of prostate cancer. The criteria for selection of miRs for this review were the availability of preclinical in vivo metastasis-related data in conjunction with prognostic clinical data. Depending on their function in the metastatic process, the corresponding miRs are up- or down-regulated in prostate cancer tissues when compared to matching normal tissues...
January 2019: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/30582859/clinical-hematological-characterization-and-polymorphism-of-abo-and-rh-blood-group-systems-in-plasma-cell-myeloma-patients
#12
T F Liubarets, Zh M Minchenko, O O Dmytrenko, V I Khomenko, L S Reznikova, T Yu Shlyahtichenko, A O Tovstogan, Yu O Silayev
Objective to study the peculiarities of clinical characteristics and polymorphism of ABO and Rh blood group systemsin relation to the natural history of plasma cell myeloma in the ChNPP accident survivors. MATERIALS AND METHODS: Peculiarities of the disease natural history were reviewed in the 111 plasma cell myeloma(PCM) patients receiving medical management at the Department of Radiation Oncohematology of the NRCRM dur-ing 2010-2017. Principal clinical and laboratory characteristics of PCM, namely the values/levels of LDH, β2-mic-roglobulin, albumin, serum calcium, urea, creatinine and hemoglobin were assessed, taking into account the gender,radiation history (ChNPP accident clean-up workers, evacuees from areas of obligatory resettlement, inhabitants ofcontaminated territories, and the comparison group) and the PCM stage codenamed by Durie-Salmon et al...
December 2018: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/30579984/micro-and-nanotechnology-approaches-to-improve-parkinson-s-disease-therapy
#13
REVIEW
Pablo Vicente Torres-Ortega, Laura Saludas, Amira Sayed Hanafy, Elisa Garbayo, María José Blanco-Prieto
Current therapies for Parkinson's disease are symptomatic and unable to regenerate the brain tissue. In recent years, the therapeutic potential of a wide variety of neuroprotective and neuroregenerative molecules such as neurotrophic factors, antioxidants and RNA-based therapeutics has been explored. However, drug delivery to the brain is still a challenge and the therapeutic efficacy of many drugs is limited. In the last decade, micro- and nanoparticles have proved to be powerful tools for the administration of these molecules to the brain, enabling the development of new strategies against Parkinson's disease...
December 20, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30579238/liquid-biopsy-mirna-as-a-potential-biomarker-in-oral-cancer
#14
REVIEW
Sayani Mazumder, Shalini Datta, Jay Gopal Ray, Keya Chaudhuri, Raghunath Chatterjee
Oral cancer is one of the leading cancers in South-Asian countries. Despite the easy access of the oral cavity, the detection and five year survival rates of OSCC patients are dismal. Identification of non-invasive biomarkers to determine the progression and recurrence of OSCC could be of immense help to patients. Recent studies on oral cancer suggest the importance of non-invasive biomarker development. Micro-RNAs (miRNAs) are one of the important components of the cell-free nucleic acids available in different body fluids...
December 19, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/30579043/nano-micro-and-macroscale-drug-delivery-systems-for-cancer-immunotherapy
#15
REVIEW
Pingsheng Huang, Xiaoli Wang, Xiaoyu Liang, Jing Yang, Chuangnian Zhang, Deling Kong, Weiwei Wang
Immunotherapy is moving to the frontier of cancer treatment. Drug delivery systems (DDSs) have greatly advanced the development of cancer immunotherapeutic regimen and combination treatment. DDSs can spatiotemporally present tumor antigens, drugs, immunostimulatory molecules, or adjuvants, thus enabling the modulation of immune cells including dendritic cells (DCs) or T-cells directly in vivo and thereby provoking robust antitumor immune responses. Cancer vaccines, immune checkpoint blockade, and adoptive cell transfer have shown promising therapeutic efficiency in clinic, and the incorporation of DDSs may further increase antitumor efficiency while decreasing adverse side effects...
December 19, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/30571645/micro-electrode-dot-array-digital-microfluidic-biochips-technology-design-automation-and-test-techniques
#16
Zhanwei Zhong, Zipeng Li, Krishnendu Chakrabarty, Tsung-Yi Ho, Chen-Yi Lee
Digital microfluidic biochips (DMFBs) are being increasingly used for DNA sequencing, point-of-care clinical diagnostics and immunoassays. DMFBs based on a micro-electrodedot-array (MEDA) architecture have recently been proposed, and fundamental droplet manipulations, e.g., droplet mixing and splitting, have also been experimentally demonstrated on MEDA biochips. There can be thousands of microelectrodes on a single MEDA biochip, and the fine-grained control of nanoliter volumes of biochemical samples and reagents is also enabled by this technology...
December 14, 2018: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/30510551/emerging-role-of-immunosuppression-in-diseases-induced-by-micro-and-nano-particles-time-to-revisit-the-exclusive-inflammatory-scenario
#17
REVIEW
François Huaux
Fibrosis, cancer, and autoimmunity developing upon particle exposure have been exclusively linked with uncontrolled inflammatory processes. The critical role of inflammation is now challenged by several contradictory observations indicating that the emergence of these chronic disorders may result from non-inflammatory events. A growing number of studies reveals that micro- and nano-particles can cause exaggerated and persistent immunosuppression characterized by the release of potent anti-inflammatory cytokines (IL-10 and TGF-β), and the recruitment of major regulatory immune cells (M2 macrophages, T and B regs, and MDSC)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30497121/-clipping-for-large-paraclinoid-internal-carotid-artery-aneurysms-by-non-fluoroscopic-occlusion-via-a-micro-bone-window-frontolateral-approach
#18
H Y Wang, Y Zhao, H Zhang, Y K Gao, W W Xin, J Z Cui, S Y Yue, S Y Yang, J N Zhang, X Y Yang
Objective: To evaluate the clinical value and outcomes of technical improvement of hybrid operatical clipping for large paraclinoid internal carotid artery aneurysms. Methods: A review was conducted on 18 cases of large paraclinoid internal carotid artery aneurysm which were clipped by balloon non-fluoroscopic occlusion of the parent artery via a micro-bone window frontolateral approach in hybrid operating room at Neurosurgery Department of Tianjin Medical University General Hospital from June 2014 to December 2017...
December 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/30489598/diabetes-and-lung-disease-a-neglected-relationship
#19
Jasmin Khateeb, Eyal Fuchs, Mogher Khamaisi
BACKGROUND: Diabetes mellitus is a systemic disorder associated with inflammation and oxidative stress which may target many organs such as the kidney, retina, and the vascular system. The pathophysiology, mechanisms, and consequences of diabetes on these organs have been studied widely. However, no work has been done on the concept of the lung as a target organ for diabetes and its implications for lung diseases. AIM: In this review, we aimed to investigate the effects of diabetes and hypoglycemic agent on lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis, pulmonary hypertension, and lung cancer...
November 23, 2018: Review of Diabetic Studies: RDS
https://www.readbyqxmd.com/read/30488033/frontiers-of-medical-micro-nanorobotics-in-vivo-applications-and-commercialization-perspectives-toward-clinical-uses
#20
REVIEW
Fernando Soto, Robert Chrostowski
The field of medical micro/nanorobotics holds considerable promise for advancing medical diagnosis and treatment due to their unique ability to move and perform complex task at small scales. Nevertheless, the grand challenge of the field remains in its successful translation towards widespread patient use. We critically address the frontiers of the current methodologies for in vivo applications and discuss the current and foreseeable perspectives of their commercialization. Although no "killer application" that would catalyze rapid commercialization has yet emerged, recent engineering breakthroughs have led to the successful in vivo operation of medical micro/nanorobots...
2018: Frontiers in Bioengineering and Biotechnology
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