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nausea and vomitting in palliative care

C M Bruce, J Smith, A Price
AIMS: The non-specialist management of cancer patients is becoming increasingly complex. Acute oncology services (AOS), aiming to provide rapid access to specialist advice, have been shown to improve patient experience and reduce length of inpatient stay. The present study aimed to inform service provision in a district general hospital (DGH) by investigating cancer patients, not on active anti-cancer treatment, where the disease itself precipitated admission. This is a vulnerable group who are potentially disenfranchised of focused oncological input due to having less robust care pathways established to date...
April 17, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
Randy L Wei, Lauren E Colbert, Joshua Jones, Margarita Racsa, Gabrielle Kane, Steve Lutz, Neha Vapiwala, Kavita V Dharmarajan
PURPOSE: The purpose of this study was to assess the state of palliative and supportive care (PSC) and palliative radiation therapy (RT) educational curricula in radiation oncology residency programs in the United States. METHODS AND MATERIALS: We surveyed 87 program directors of radiation oncology residency programs in the United States between September 2015 and November 2015. An electronic survey on PSC and palliative RT education during residency was sent to all program directors...
December 1, 2016: Practical Radiation Oncology
Lauren Colbert, Joshua Adam Jones, Gabrielle Kane, Margarita Racsa-Alamgir, Neha Vapiwala, Kavita Vyas Dharmarajan
178 Background: To assess the state of palliative care education curricula in radiation oncology residency programs in the United States. METHODS: We surveyed 90 program directors of radiation oncology residency programs in the United States from September 2015 to November 2015. An electronic survey on palliative care education during residency was sent to all program directors. The survey consisted of questions on perceived relevance of palliative care in radiation oncology residency, formal didactics on domains of palliative care, effective teaching formats for palliative care education, and perceived barriers for integrating palliative care into the residency curriculum...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Anna Winthereik, Mette Neergaard, Peter Vedsted, Anders Jensen
OBJECTIVE: General practitioners (GPs) are pivotal in end-of-life (EOL) care. This study aimed to assess GP-reported provision of EOL care and to assess associations with GP characteristics. DESIGN: Population-based questionnaire study. SETTING: Central Denmark Region with approximately 1.3 million inhabitants. SUBJECTS: All 843 active GPs in the Central Denmark Region were sent a questionnaire by mail. MAIN OUTCOME MEASURES: Responses to 18 items concerning four aspects: provision of EOL care to patients with different diagnosis, confidence with being a key worker, organisation of EOL care and EOL skills (medical and psychosocial)...
December 2016: Scandinavian Journal of Primary Health Care
Pedro C Barata, Alice Cardoso, Maria P Custodio, Marta Alves, Ana L Papoila, Barbosa António, Peter G Lawlor
This study aimed to identify clusters of symptoms, to determine the patient characteristics associated with identified, and determine their strength of association with survival in patients with advanced cancer (ACPs). Consecutively eligible ACPs not receiving cancer-specific treatment, and referred to a Tertiary Palliative Care Clinic, were enrolled in a prospective cohort study. At first consultation, patients rated 9 symptoms through the Edmonton Symptom Assessment System (0-10 scale) and 10 others using a Likert scale (1-5)...
September 13, 2016: Cancer Medicine
Naveen Salins, Lipika Patra, M R Usha Rani, S O Lohitashva, Raghavendra Rao, Raghavendra Ramanjulu, Nandini Vallath
INTRODUCTION: Palliative care is usually delivered late in the course of illness trajectory. This precludes patients on active disease modifying treatment from receiving the benefit of palliative care intervention. A survey was conducted to know the opinion of oncologists, oncology nurses, and patients about the role of early specialist palliative care in cancer. METHODS: A nonrandomized descriptive cross-sectional study was conducted at a tertiary cancer care center in India...
July 2016: Indian Journal of Palliative Care
Kathleen E Bickel, Kristen McNiff, Mary K Buss, Arif Kamal, Dale Lupu, Amy P Abernethy, Michael S Broder, Charles L Shapiro, Anupama Kurup Acheson, Jennifer Malin, Tracey Evans, Monika K Krzyzanowska
PURPOSE: Integrated into routine oncology care, palliative care can improve symptom burden, quality of life, and patient and caregiver satisfaction. However, not all oncology practices have access to specialist palliative medicine. This project endeavored to define what constitutes high-quality primary palliative care as delivered by medical oncology practices. METHODS: An expert steering committee outlined 966 palliative care service items, in nine domains, each describing a candidate element of primary palliative care delivery for patients with advanced cancer or high symptom burden...
September 2016: Journal of Oncology Practice
Mustafa Süren, İsmail Okan, Ziya Kaya, Serkan Karaman, Semih Arici, Mevlüt Çömlekçi, Murat Ayan, Mehmet Esen, Serkan Doğru, Aynur Şahin, Tuğba Karaman
BACKGROUND/AIM: We investigated the symptoms and needs of terminal cancer patients in a region where formal palliative care is limited. Here we present the demographic features and symptoms of end-stage cancer patients living in a city in northern Turkey. MATERIALS AND METHODS: The study was conducted at Gaziosmanpaşa University (Tokat, Turkey), in 2011 and 2012. End-stage cancer patients admitted or referred by various departments to our outpatient pain unit were included...
February 17, 2014: Turkish Journal of Medical Sciences
Florence T Baralatei, Richard J Ackermann
Management of nonpain symptoms can improve quality of life for patients at the end of life and their family members. Constipation is the most common nonpain symptom. It can be related to opioid therapy and/or medical conditions. After abdominal examination to detect masses or evidence of bowel obstruction and rectal examination to exclude fecal impaction, constipation should be managed with a stimulant laxative (eg, senna) or an osmotic laxative (eg, sorbitol). Dyspnea also is common, and often improves with use of a fan to blow air into the face, as well with breathing and relaxation exercises...
2016: FP Essentials
Hanife Ozcelik, Yasemin Guzel, Esra Sonmez, Fatma Aksoy, Ruchan Uslu
OBJECTIVE: Assessing quality of life, which is the main focus of palliative care, is highly important. The number of available, specific, simple, and valid assessment instruments for patients with advanced cancer in Turkey is limited. The aim of our study was to perform a psychometric evaluation of the Turkish version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 15-PAL (EORTC QLQ-C15-PAL). METHOD: The study was conducted in İzmir with patients who had received treatment in the palliative care unit of a university hospital between November of 2011 and December of 2013...
December 2016: Palliative & Supportive Care
Hayley Barnes, Julie McDonald, Natasha Smallwood, Renée Manser
BACKGROUND: Breathlessness is a common and disabling symptom which affects many people with advanced cardiorespiratory disease and cancer. The most effective treatments are aimed at treating the underlying disease. However, this may not always be possible, and symptomatic treatment is often required in addition to maximal disease-directed therapy. Opioids are increasingly being used to treat breathlessness, although their mechanism of action is still not completely known. A few good sized, high quality trials have been conducted in this area...
March 31, 2016: Cochrane Database of Systematic Reviews
Snezana M Bosnjak, Jelena Dimitrijevic, Fedja Djordjevic
PURPOSE OF THE REVIEW: The purpose of review is to critically present the evidence supporting the use of olanzapine, an atypical antipsychotic, as an antiemetic for cancer and chemotherapy-induced nausea and vomiting (CINV). RECENT FINDINGS: Two phase III clinical studies demonstrated superior efficacy of olanzapine in comparison with the neurokinin-1 receptor antagonists (NK1RA) for substance P (aprepitant, fosaprepitant) in the prevention of nausea after highly emetogenic chemotherapy...
June 2016: Current Opinion in Supportive and Palliative Care
James R Eiszner, Alfred Atanda, Ashwin Rangavajjula, Mary Theroux
AIM: The purpose of this study was to report our experience with peripheral nerve blockade in pediatric and young adult patients with skeletal dysplasia undergoing knee arthroscopy. BACKGROUND: The incidence of skeletal dysplasia is 1:4000 live births. These patients have biomechanical predispositions to knee joint degeneration, which is often palliated by arthroscopic surgery. Regional anesthesia has been proven to improve the cost and quality of care in adults undergoing arthroscopic knee surgery...
May 2016: Paediatric Anaesthesia
Nicholas Chiu, Leonard Chiu, Marko Popovic, Carlo DeAngelis, Mark Pasetka, Stephen Lutz, Na Zhang, Gustavo Nader Marta, Lucas Castro Mendez, Breanne Lechner, Natalie Pulenzas, Milica Milakovic, Ronald Chow, Edward Chow
Palliative radiotherapy (RT) is an effective treatment for symptomatic bone metastases. However, pain flare, nausea and vomiting are common adverse effects associated with this treatment. The management of pain flare and radiation-induced nausea and vomiting (RINV) are important endpoints in palliative care. Our report documents the incidence, clinical importance, and advances in the management of these two adverse-effects. We recommend that antiemetic prophylaxis be given based on emetic risk category as outlined in the American Society of Clinical Oncology (ASCO) guidelines...
January 2016: Annals of Palliative Medicine
Keisuke Kaneishi, Kazunori Nishimura, Norio Sakurai, Kengo Imai, Naoki Matsuo, Naoko Takahashi, Kenichiro Okamoto, Akihiko Suga, Hiromi Sano, Isseki Maeda, Haruhiro Nishina, Takuhiro Yamaguchi, Tatsuya Morita, Satoru Iwase
Nausea and vomiting are among the most common and distressing symptoms in patients with advanced cancer. Olanzapine, an antipsychotic agent, is known to have an affinity for multiple neurotransmitter receptors. Previous studies have reported olanzapine to be efficacious in the treatment of nausea and vomiting. Although it has been administered at a number of facilities, its applicability to treat nausea and vomiting in patients with advanced cancer is poorly understood. We investigated the use of olanzapine for nausea and vomiting in patients with advanced cancer at multiple centers...
June 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
M Mücke, C Carter, H Cuhls, M Prüß, L Radbruch, W Häuser
BACKGROUND: Cannabinoids have multiple medical indications in palliative care, such as relief of pain or nausea or increase of appetite and weight stabilisation. The value of cannabinoids for these indications is not resolved sufficiently for palliative patients. A systematic review with meta-analysis of the efficacy, tolerability and safety on the basis of randomised controlled studies (RCT) or randomised open label or crossover studies has not yet been conducted. MATERIALS AND METHODS: An extensive search for RCTs, randomised open label or crossover studies dealing with the underlying question was performed in the databases of Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, PsycINFO, PubMed, Scopus and Clinicaltrials...
February 2016: Der Schmerz
Emily Collis, Harriet Mather
No abstract text is available yet for this article.
December 3, 2015: BMJ: British Medical Journal
Xinyin Wu, Vincent C H Chung, Edwin P Hui, Eric T C Ziea, Bacon F L Ng, Robin S T Ho, Kelvin K F Tsoi, Samuel Y S Wong, Justin C Y Wu
Acupuncture and related therapies such as moxibustion and transcutaneous electrical nerve stimulation are often used to manage cancer-related symptoms, but their effectiveness and safety are controversial. We conducted this overview to summarise the evidence on acupuncture for palliative care of cancer. Our systematic review synthesised the results from clinical trials of patients with any type of cancer. The methodological quality of the 23 systematic reviews in this overview, assessed using the Methodological Quality of Systematic Reviews Instrument, was found to be satisfactory...
2015: Scientific Reports
Marvin Omar Delgado-Guay, Alfredo Rodriguez-Nunez, Seong Hoon Shin, Gary Chisholm, Janet Williams, Susan Frisbee-Hume, Eduardo Bruera
PURPOSE: Patients with advanced cancer may be referred for a palliative care consultation (PC) from a hospital emergency center (EC) or as inpatients. However, research about symptoms and outcomes in patients with advanced cancer who receive PC at the EC is limited. METHODS: We reviewed demographic variables, frequency and intensity of symptoms (using the Edmonton Symptom Assessment Scale (ESAS)), PC interventions, time from admission to PC consultation, hospitalization duration, and discharge destination of 200 advanced cancer patients referred to PC services from the EC ("EC patients") and 200 matched advanced cancer inpatients referred to PC services ("inpatients") from January 1, 2010, through December 31, 2011...
May 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Agnieszka Górska, Michał Marszałł, Anna Sloderbach
Haloperydol is a butyrophenone, typical neuroleptic agent characterized as a high antipsychotics effects in the treatment of schizophrenia and in palliative care to alleviation many syndromes, such as naursea, vomiting and delirium. Clinical problems occurs during and after administration of the drug are side effects, particularly extrapyrramidal symptoms (EPS). The neurotoxicity of haloperydol may be initiated by the cationic metabolites of haloperydol, HPP+, RHPP+, formed by oxidation and reduction pathways...
October 19, 2015: Postȩpy Higieny i Medycyny Doświadczalnej
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