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https://www.readbyqxmd.com/read/29027350/liposome-encapsulated-chemotherapy-current-evidence-for-its-use-in-companion-animals
#1
REVIEW
B Børresen, A E Hansen, A Kjaer, T L Andresen, A T Kristensen
Cytotoxic drugs encapsulated into liposomes were originally designed to increase the anticancer response, while minimizing off-target adverse effects. The first liposomal chemotherapeutic drug was approved for use in humans more than 20 years ago, and the first publication regarding its use in a canine cancer patient was published shortly thereafter. Regardless, no general application for liposomal cytotoxic drugs has been established in veterinary oncology till now. Due to the popularity of canines as experimental models for pharmacokinetic analyses and toxicity studies, multiple publications exist describing various liposomal drugs in healthy dogs...
October 13, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28993600/triple-phase-helical-computed-tomography-in-dogs-with-solid-splenic-masses
#2
Kenji Kutara, Mamiko Seki, Kumiko Ishigaki, Kenji Teshima, Chieko Ishikawa, Yumiko Kagawa, Kazuya Edamura, Tomohiro Nakayama, Kazushi Asano
We investigated the utility of triple-phase helical computed tomography (CT) in differentiating between benign and malignant splenic masses in dogs. Forty-two dogs with primary splenic masses underwent triple-phase helical CT scanning (before administration of contrast, and in the arterial phase, portal venous phase, and delayed phase) prior to splenectomy. Tissue specimens were sent for pathological diagnosis; these included hematomas (n=14), nodular hyperplasias (n=12), hemangiosarcomas (n=11), and undifferentiated sarcomas (n=5)...
October 7, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28973697/fenretinide-troglitazone-and-elmiron-add-to-weight-of-evidence-support-for-hemangiosarcoma-mode-of-action-from-studies-in-mice
#3
Jon C Cook, Leslie A Obert, Petra Koza-Taylor, Tim Coskran, Alan Opsahl, Daniel Ziemek, Marc Roy, Jessie Qian, Michael P Lawton, Kay Criswell
Pharmaceuticals and chemicals produce hemangiosarcomas (HS) in mice, often by nongenotoxic, proliferative mechanisms. A mode-of-action (MOA) for hemangiosarcoma was proposed based on information presented at an international workshop (Cohen et al., 2009). Five key elements of the MOA were articulated and included hypoxia, macrophage activation, increased angiogenic growth factors, dysregulated angiogenesis/erythropoiesis, and endothial cell proliferation. The goal of the current study was to add to the weight-of-evidence for the proposed MOA by assessing these key elements with three different compounds of varying potency for HS induction: fenretinide (high), troglitazone (intermediate), and elmiron (low)...
September 18, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28966362/hemangiosarcoma-within-an-intermuscular-lipoma-in-a-golden-retriever-dog
#4
Claire Leriquier, Marie-Odile Benoit-Biancamano, Hugues Lacoste, Gregory D Herndon
A subcutaneous mass on the right pelvic limb of an 11-year-old neutered male golden retriever dog was surgically excised. A hemangiosarcoma included within an intermuscular lipoma was diagnosed upon histopathological examination. To the authors' knowledge, this is the first case report of this nature in a dog.
October 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28959926/malignant-collision-tumors-in-two-dogs
#5
Jacqueline E Scott, Julius M Liptak, Barbara E Powers
CASE DESCRIPTION A 13-year-old Labrador Retriever with a 4-cm-diameter ulcerated perianal mass and a 12-year-old Golden Retriever with a 5-cm-diameter ulcerated caudolateral abdominal mass were brought to a referral oncology practice for evaluation of the dermal masses. Both masses were resected with wide margins without reported postoperative complications. For both dogs, a diagnosis of collision tumor was made. The database of the Veterinary Diagnostic Laboratories at Colorado State University was searched for other examples of collision tumors in dogs...
October 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28933507/renal-neoplasia-in-horses-a-retrospective-study
#6
Julia Vienenkötter, Krystyna Siudak, Lena Stallenberger, Christiane Herden
OBJECTIVE: Being confronted with a case series of renal neoplasia in several horses which was in striking divergence to literature data, we recognized the need of a retrospective study to assess the presence of renal neoplasms in horses. MATERIAL AND METHODS: Anamnestic animal data, necropsy findings and results of histological and immunohistochemical examinations from 2010 through 2015 were collected and evaluated regarding renal neoplasia. RESULTS: Data from postmortem examinations of 1069 horses revealed 20 horses with renal tumors constituting a prevalence of 1...
September 20, 2017: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/28892429/adjuvant-doxorubicin-with-or-without-metronomic-cyclophosphamide-for-canine-splenic-hemangiosarcoma
#7
Arata Matsuyama, Valerie J Poirier, Fernanda Mantovani, Robert A Foster, Anthony J Mutsaers
This retrospective study investigated the outcome of 33 dogs with splenic hemangiosarcoma treated with surgery followed by adjuvant dose-intensified doxorubicin (DOX) with or without low-dose metronomic cyclophosphamide (LDM-C) maintenance therapy. Among the 33 dogs, 18 dogs received LDM-C. Clinical stage was available for all dogs (5 stage I, 18 stage II, and 10 stage III). Nine dogs had macroscopic, and 24 dogs had microscopic disease at the start of DOX treatment. Median progression-free survival (PFS) and overall survival were 125 and 133 days, respectively...
September 11, 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28828962/evaluation-of-clinical-and-histologic-factors-associated-with-survival-time-in-dogs-with-stage-ii-splenic-hemangiosarcoma-treated-by-splenectomy-and-adjuvant-chemotherapy-30-cases-2011-2014
#8
Antony S Moore, Kenneth M Rassnick, Angela E Frimberger
OBJECTIVE To determine histologic and clinical factors associated with survival time in dogs with stage II splenic hemangiosarcoma treated by splenectomy and a chemotherapy protocol in which an anthracycline was alternated with lomustine. DESIGN Retrospective case series. ANIMALS 30 dogs with stage II splenic hemangiosarcoma. PROCEDURES Medical records of 3 facilities were reviewed to identify dogs treated for stage II splenic hemangiosarcoma between June 2011 and October 2014. Information collected included signalment, disease staging data, whether anemia was present, date of splenectomy, chemotherapy protocol, adverse effects, and date of death or last follow-up...
September 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28820464/enhanced-susceptibility-of-ogg1-mutant-mice-to-multiorgan-carcinogenesis
#9
Anna Kakehashi, Naomi Ishii, Takahiro Okuno, Masaki Fujioka, Min Gi, Hideki Wanibuchi
The role of deficiency of oxoguanine glycosylase 1 (Ogg1) Mmh homolog, a repair enzyme of the 8-hydroxy-2'-deoxyguanosine (8-OHdG) residue in DNA, was investigated using the multiorgan carcinogenesis bioassay in mice. A total of 80 male and female six-week-old mice of C57BL/6J background carrying a mutant Mmh allele of the Mmh/Ogg1 gene (Ogg1(-)(/)(-)) and wild type (Ogg1(+/+)) mice were administered N-diethylnitrosamine (DEN), N-methyl-N-nitrosourea (MNU), N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN), N-bis (2-hydroxypropyl) nitrosamine (DHPN) and 1,2-dimethylhydrazine dihydrochloride (DMH) (DMBDD) to induce carcinogenesis in multiple organs, and observed up to 34 weeks...
August 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28768863/hras-egfr-met-and-ron-genes-are-recurrently-activated-by-provirus-insertion-in-liver-tumors-induced-by-the-retrovirus-myeloblastosis-associated-virus-2
#10
Vladimir Pecenka, Petr Pajer, Vít Karafiat, Petra Kasparova, Jana Dudlova, Michal Dvorak
Myeloblastosis-associated virus 2 (MAV-2) is a highly tumorigenic simple avian retrovirus. Chickens infected in ovo with MAV-2 develop tumors in the kidneys, lungs, and liver with a short latency, less than 8 weeks. Here we report the results of molecular analyses of MAV-2-induced liver tumors that fall into three classes: hepatic hemangiosarcomas (HHSs), intrahepatic cholangiocarcinomas (ICCs), and hepatocellular carcinomas (HCCs). Comprehensive inverse PCR-based screening of 92 chicken liver tumors revealed that in ca...
October 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28762232/morphofunctional-basis-of-the-different-types-of-angiogenesis-and-formation-of-postnatal-angiogenesis-related-secondary-structures
#11
REVIEW
L Díaz-Flores, R Gutiérrez, M P García-Suárez, F J Sáez, E Gutiérrez, F Valladares, J L Carrasco, L Díaz-Flores, J F Madrid
We review the morpho-functional basis of the different types of angiogenesis and report our observations, including the formation of angiogenesis-related secondary structures. First of all, we consider the following issues: a) conceptual differences between angiogenesis and vasculogenesis, b) incidence of angiogenesis in pre- and postnatal life, c) regions of vascular tree with angiogenic capacity, d) cells (endothelial cells, pericytes, CD34+ adventitial stromal cells of the microvasculature and inflammatory cells) and extracellular matrix components involved in angiogenesis, e) events associated with angiogenesis, f) different types of angiogenesis, including sprouting and intussusceptive angiogenesis, and other angiogenic or vascularization forms arising from endothelial precursor cells (postnatal vasculogenesis), vasculogenesis mimicry, vessel co-option and piecemeal angiogenesis...
August 1, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28752536/multimodality-imaging-of-primary-ureteral-hemangiosarcoma-with-thoracic-metastasis-in-an-adult-dog
#12
Daniele Troiano, Micaela Zarelli
A 12-year-old spayed female standard Poodle was presented for investigation of severe hematuria. Abdominal ultrasound and thoracic and abdominal computed tomography identified severe hydronephrosis due to an obstructive ureteral mass with no evidence of metastasis. Histological examination after nephrectomy and ureterectomy confirmed an obstructive ureteral hemangiosarcoma. Forty days after surgery, the dog was presented with severe dyspnea. Survey radiographs of the thorax revealed a severe diffuse nodular interstitial pattern...
July 27, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28560045/correlation-of-neuter-status-and-expression-of-heritable-disorders
#13
Janelle M Belanger, Thomas P Bellumori, Danika L Bannasch, Thomas R Famula, Anita M Oberbauer
BACKGROUND: Gonadectomy, or neutering, is a very common surgery for dogs having many positive effects on behavior, health, and longevity. There are also certain risks associated with neutering including the development of orthopedic conditions, cognitive decline, and a predisposition to some neoplasias. This study was designed specifically to identify if a correlation exists between neuter status and inherited conditions in a large aggregate cohort of dogs representing many different breeds...
2017: Canine Genetics and Epidemiology
https://www.readbyqxmd.com/read/28536479/circulating-microrna-214-and-126-as-potential-biomarkers-for-canine-neoplastic-disease
#14
Kazuki Heishima, Yukie Ichikawa, Kyoko Yoshida, Ryota Iwasaki, Hiroki Sakai, Takayuki Nakagawa, Yuiko Tanaka, Yuki Hoshino, Yasuhiko Okamura, Mami Murakami, Kohji Maruo, Yukihiro Akao, Takashi Mori
Circulating microRNAs in the blood may provide diagnostic and prognostic information about canine neoplastic diseases, and their profiles may be conserved between human and canine species. We performed RT-qPCR to obtain the profiles of circulating plasma microRNA-214 and -126 in total 181 cases of canine neoplastic diseases and healthy controls. MicroRNA-214 levels were high in 2 epithelial tumours (thyroid and mammary carcinomas) and 4 non-epithelial tumours (osteosarcoma, histiocytic sarcoma, chondrosarcoma, and hemangiosarcoma)...
May 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28526098/first-description-of-bartonella-koehlerae-infection-in-a-spanish-dog-with-infective-endocarditis
#15
María-Dolores Tabar, Laura Altet, Ricardo G Maggi, Jaume Altimira, Xavier Roura
BACKGROUND: Bartonella koehlerae has been recently described as a new cat- and cat fleas-associated agent of culture-negative human endocarditis. It has been also encountered in one dog from Israel and six dogs from the USA, but other clinically relevant reports involving this bacterium are lacking. RESULTS: A 7-year-old intact male mixed dog presented with clinico-pathological signs consistent with mitral endocarditis and cutaneous hemangiosarcoma. Molecular studies revealed the presence of Bartonella koehlerae DNA in samples from blood and mitral valve tissue...
May 19, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28509648/video-assisted-extirpation-of-cranial-mediastinal-masses-in-dogs-18-cases-2009-2014
#16
MULTICENTER STUDY
Melissa A MacIver, J Brad Case, Eric L Monnet, Geraldine B Hunt, Philipp D Mayhew, Michelle L Oblak, Jeffrey J Runge, Ameet Singh, Daniel D Smeak, Michele A Steffey, Sarah E Boston
OBJECTIVE To characterize clinical findings, surgical procedures, complications, and outcomes in dogs undergoing extirpation of masses from the cranial mediastinum via video-assisted thoracic surgery (VATS) and establish preliminary guidelines for case selection when considering VATS for thymectomy in dogs. DESIGN Retrospective case series. ANIMALS 18 client-owned dogs that underwent extirpation of a cranial mediastinal mass by means of VATS at 5 academic referral hospitals from 2009 through 2014. PROCEDURES Medical records were reviewed and data extracted regarding signalment, clinical signs, physical examination findings, diagnostic imaging results, surgical approach and duration, cytologic and histologic examination results, complications, outcome, and cause of death, when applicable...
June 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28467747/splenomegaly-in-small-breed-dogs-45-cases-2005-2011
#17
Erin E Corbin, Ryan P Cavanaugh, Pamela Schwartz, Katherine I Zawadzki, Taryn Donovan
OBJECTIVE To assess causes of splenomegaly and postsurgical outcomes in small-breed (ie, < 16-kg [< 35.2-lb]) dogs that underwent splenectomy and evaluate associations among malignant disease, hemoperitoneum, and survival time in these patients. DESIGN Retrospective case series. ANIMALS 45 client-owned dogs. PROCEDURES Medical records of 2 veterinary facilities were reviewed to identify small-breed dogs that underwent splenectomy and had a histologic diagnosis recorded. Data analyzed included signalment, diagnosis, presence or absence of hemoperitoneum, and survival time...
May 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28375825/spontaneous-neoplasms-in-captive-virginia-opossums-didelphis-virginiana-a-retrospective-case-series-1989-2014-and-review-of-the-literature
#18
Jenny P Pope, Robert L Donnell
This retrospective project summarizes the types of neoplasms identified in Virginia opossums ( Didelphis virginiana) presented to the University of Tennessee, College of Veterinary Medicine (UTCVM) postmortem service in 1989-2014 and serves as a review of the literature. Of the 85 Virginia opossums identified from the UTCVM case database, there were 17 diagnoses of neoplasia from 12 cases (14%). These cases included 8 females, 2 males, and 2 neutered males. All opossums with known ages (11 of 12) were >2 y old...
May 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28285583/molecular-detection-of-vector-borne-pathogens-in-blood-and-splenic-samples-from-dogs-with-splenic-disease
#19
Rebeca Movilla, Laura Altet, Lorena Serrano, María-Dolores Tabar, Xavier Roura
BACKGROUND: The spleen is a highly perfused organ involved in the immunological control and elimination of vector-borne pathogens (VBP), which could have a fundamental role in the pathogenesis of splenic disease. This study aimed to evaluate certain VBP in samples from dogs with splenic lesions. METHODS: Seventy-seven EDTA-blood and 64 splenic tissue samples were collected from 78 dogs with splenic disease in a Mediterranean area. Babesia spp., Bartonella spp., Ehrlichia/Anaplasma spp...
March 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28283317/pilot-study-to-determine-the-feasibility-of-radiation-therapy-for-dogs-with-right-atrial-masses-and-hemorrhagic-pericardial-effusion
#20
M W Nolan, M M Arkans, D LaVine, T DeFrancesco, J A Myers, E H Griffith, L P Posner, B W Keene, S P Tou, T L Gieger
OBJECTIVES: To determine the short-term safety and biologic activity of radiation therapy (RT) for presumptive cardiac hemangiosarcoma in pet dogs. ANIMALS: Six dogs with echocardiographic evidence of a right atrial/auricular mass, and hemorrhagic pericardial effusion, were enrolled in a prospective, single-arm clinical trial. METHODS: A single fraction of 12 Gy was delivered using conformal external beam irradiation. Serum cardiac troponin I and plasma concentrations of vascular endothelial growth factor were quantified before, 4 and 24 h after RT...
April 2017: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
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