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https://www.readbyqxmd.com/read/27912752/a-comparison-of-microrna-expression-profiles-from-splenic-hemangiosarcoma-splenic-nodular-hyperplasia-and-normal-spleens-of-dogs
#1
Janet A Grimes, Nripesh Prasad, Shawn Levy, Russell Cattley, Stephanie Lindley, Harry W Boothe, Ralph A Henderson, Bruce F Smith
BACKGROUND: Splenic masses are common in older dogs; yet diagnosis preceding splenectomy and histopathology remains elusive. MicroRNAs (miRNAs) are short, non-coding RNAs that play a role in post-transcriptional regulation, and differential expression of miRNAs between normal and tumor tissue has been used to diagnose neoplastic diseases. The objective of this study was to determine differential expression of miRNAs by use of RNA-sequencing in canine spleens that were histologically confirmed as hemangiosarcoma, nodular hyperplasia, or normal...
December 3, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27779362/role-of-monocyte-recruitment-in-hemangiosarcoma-metastasis-in-dogs
#2
D P Regan, A Escaffi, J Coy, J Kurihara, S W Dow
Canine hemangiosarcoma (HSA) is a highly malignant tumour associated with short survival times because of early and widespread metastasis. In humans and rodents, monocytes play key roles in promoting tumour metastasis through stimulating tumour cell extravasation, seeding, growth and angiogenesis. Therefore, we investigated the potential association between monocyte infiltration and tumour metastasis in HSA and other common canine tumours. Immunohistochemistry was used to quantify CD18(+) monocytes within metastases...
October 25, 2016: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/27767434/primary-nodal-hemangiosarcoma-in-four-dogs
#3
Catherine M Chan, Courtney H Zwahlen, Louis-Philippe de Lorimier, Stephen M Yeomans, Karon L Hoffmann, Antony S Moore
CASE DESCRIPTION 4 dogs with a slow-growing mass in the cervical region were evaluated. CLINICAL FINDINGS All dogs had no clinical signs at the time of the evaluation. There was no apparent evidence of visceral metastases or other primary tumor based on available CT or MRI data for any dog. TREATMENT AND OUTCOME For each dog, surgery to remove the mass was performed. Histologic examination of the excised tissue revealed a completely excised grade 1 or 2 lymph node hemangiosarcoma. All dogs received adjuvant chemotherapy; 2 dogs underwent curative intent chemotherapy, 1 dog underwent metronomic treatment with cyclophosphamide, and 1 dog underwent metronomic treatment with chlorambucil...
November 1, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27746404/primary-intrapelvic-hemangiosarcoma-in-a-dog
#4
Saejong Yoo, Jiyong Kim, Hyun-Wook Myung, Suhan Woo, Dai-Jung Chung, A-Jin Lee, Han-Jun Kim, Sun-Hee DO, Hwi-Yool Kim
A 12-year-old, spayed female Schnauzer presented with constipation. A mass was observed in the pelvic cavity, and metastasis was not identified. Mass resection was performed through celiotomy with pubic osteotomy, and hemangiosarcoma was diagnosed. At 10 weeks post-operatively, the patient died of multiple metastasis. Primary intrapelvic hemangiosarcoma is rare in dogs.
October 15, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27699974/imaging-diagnosis-ultrasonographic-appearance-of-skeletal-muscle-metastases-in-a-dog-with-hemangiosarcoma
#5
Martina Fabbi, Stefano Di Palma, Sabrina Manfredi, Giacomo Gnudi, Francesca Miduri, Eleonora Daga, Gabriele Costantino Melis, Ezio Bianchi, Simone Voccia, Antonella Volta
A 13-year-old spayed female German shepherd dog was presented for acute onset of lethargy, anorexia, and disseminated erythematous skin lesions. Thoracic radiographs and abdominal ultrasonographic findings were consistent with metastatic hemangiosarcoma. Multiple, ill-defined, irregularly shaped hypoechoic nodules were also detected within the thoracic and abdominal wall. Hemangiosarcoma metastases to the skeletal muscle were confirmed based on histopathological examination. Multivisceral involvement was also confirmed by necropsy...
October 4, 2016: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/27677669/glyphosate-rodent-carcinogenicity-bioassay-expert-panel-review
#6
Gary M Williams, Colin Berry, Michele Burns, Joao Lauro Viana de Camargo, Helmut Greim
Glyphosate has been rigorously and extensively tested for carcinogenicity by administration to mice (five studies) and to rats (nine studies). Most authorities have concluded that the evidence does not indicate a cancer risk to humans. The International Agency for Research on Cancer (IARC), however, evaluated some of the available data and concluded that glyphosate probably is carcinogenic to humans. The expert panel convened by Intertek assessed the findings used by IARC, as well as the full body of evidence and found the following: (1) the renal neoplastic effects in males of one mouse study are not associated with glyphosate exposure, because they lack statistical significance, strength, consistency, specificity, lack a dose-response pattern, plausibility, and coherence; (2) the strength of association of liver hemangiosarcomas in a different mouse study is absent, lacking consistency, and a dose-response effect and having in high dose males only a significant incidence increase which is within the historical control range; (3) pancreatic islet-cell adenomas (non-significant incidence increase), in two studies of male SD rats did not progress to carcinomas and lacked a dose-response pattern (the highest incidence is in the low dose followed by the high dose); (4) in one of two studies, a non-significant positive trend in the incidence of hepatocellular adenomas in male rats did not lead to progression to carcinomas; (5) in one of two studies, the non-significant positive trend in the incidence of thyroid C-cell adenomas in female rats was not present and there was no progression of adenomas to carcinomas at the end of the study...
September 2016: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/27585244/alternative-lengthening-of-telomeres-does-exist-in-various-canine-sarcomas
#7
Theresa Kreilmeier, Sandra Sampl, Abigail J Deloria, Ingrid Walter, Martin Reifinger, Marlene Hauck, Luke B Borst, Klaus Holzmann, Miriam Kleiter
Alternative lengthening of telomeres (ALT) is a telomere maintenance mechanism (TMM) found in some human tumors such as sarcomas. Canine tumors are not characterized for ALT and the study aim was to identify if the ALT phenotype exists in canine sarcomas. Sixty-four canine sarcoma samples (20 snap-frozen, 44 FFPE) as well as six canine sarcoma cell lines were screened for ALT by C-circle assay. ALT was further evaluated by measuring telomere length via qPCR and telomere restriction-fragments including pulsed-field electrophoresis...
September 1, 2016: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/27528400/fischer-344-tp53-knockout-rats-exhibit-a-high-rate-of-bone-and-brain-neoplasia-with-frequent-metastasis
#8
Sarah A Hansen, Marcia L Hart, Susheel Busi, Taybor Parker, Angela Goerndt, Kevin Jones, James M Amos-Landgraf, Elizabeth C Bryda
Somatic mutations in the Tp53 tumor suppressor gene are the most commonly seen genetic alterations in cancer, and germline mutations in Tp53 predispose individuals to a variety of early-onset cancers. Development of appropriate translational animal models that carry mutations in Tp53 and recapitulate human disease are important for drug discovery, biomarker development and disease modeling. Current Tp53 mouse and rat models have significant phenotypic and genetic limitations, and often do not recapitulate certain aspects of human disease...
October 1, 2016: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/27507032/use-of-routine-histopathology-and-factor-viii-related-antigen-von-willebrand-factor-immunohistochemistry-to-differentiate-primary-hemangiosarcoma-of-bone-from-telangiectatic-osteosarcoma-in-54-dogs
#9
M A Giuffrida, N J Bacon, D A Kamstock
Hemangiosarcoma (HSA) of bone and telangiectatic osteosarcoma (tOSA) can appear similar histologically, but differ in histogenesis (malignant endothelial cells versus osteoblasts), and may warrant different treatments. Immunohistochemistry (IHC) for endothelial cell marker factor VIII-related antigen/von Willebrand factor (FVIII-RAg/vWF) is a well-documented ancillary test to confirm HSA diagnoses in soft tissues, but its use in osseous HSA is rarely described. Archived samples of 54 primary appendicular bone tumours previously diagnosed as HSA or tOSA were evaluated using combination routine histopathology (RHP) and IHC...
August 9, 2016: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/27493283/outcome-and-prognostic-factors-for-dogs-with-a-histological-diagnosis-of-splenic-hematoma-following-splenectomy-35-cases-2001-2013
#10
Steve G Patten, Sarah E Boston, Gabrielle J Monteith
Canine splenic hematoma can be indistinguishable from hemangiosarcoma on clinical presentation and grossly at the time of surgery. However, hemangiosarcoma represents an aggressive malignancy and a misdiagnosis of hematoma would forgo indications for chemotherapy. This study describes a long-term follow-up of cases with a histologic diagnosis of splenic hematoma following splenectomy to determine if the clinical course of the disease corroborated the diagnosis. Thirty-five dogs were evaluated to determine survival and prognostic associations with signalment and clinical data...
August 2016: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/27487352/hemothorax-in-three-dogs-with-intrathoracic-extracardiac-hemangiosarcoma
#11
Lynda Rutherford, Anneliese Stell, Ken Smith, Nicola Kulendra
Intrathoracic extracardiac hemangiosarcoma (HSA) is rare in dogs. This report describes three dogs with acute onset dyspnea due to hemorrhagic pleural effusion resulting from intrathoracic extracardiac masses, which were confirmed as HSA by histopathology. The dogs were stabilized with thoracocentesis and intravascular fluid resuscitation. Computed tomography identified intrathoracic masses, which were not originating from the heart or pulmonary parenchyma. Surgical exploration was performed in all cases. Case 1 was euthanized intraoperatively as the tumor could not be dissected from the aorta...
September 2016: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/27456773/stage-specific-embryonic-antigen-ssea-determining-the-expression-in-canine-glioblastoma-melanoma-and-mammary-cancer-cells
#12
Weiming Lin, Jaime F Modiano, Daisuke Ito
The expression of stage-specific embryonic antigens (SSEAs) was determined in multiple canine cancer cells. Flow cytometry showed SSEA-1 expression in glioblastoma, melanoma and mammary cancer cells, although none expressed SSEA-3 or SSEA-4. SSEA-1 expression was not detectable in lymphoma, osteosarcoma, or hemangiosarcoma cell lines. Relatively stable SSEA-1 expression was observed after 24, 48 and 72 h of culture, and sorted SSEA-1(-) and SSEA-1(+) cells following 8-days in culture re-established comparable expression levels of SSEA-1 as were seen in unsorted cells...
July 25, 2016: Journal of Veterinary Science
https://www.readbyqxmd.com/read/27440821/progression-of-serosal-vascular-proliferative-lesions-to-hemangiosarcomas-in-the-uterus-of-the-26-week-tg-rash2-mice-carcinogenicity-studies
#13
Madhav G Paranjpe, Jessica L Belich, Dayauna R Richardson, Tom Vidmar, Peter C Mann, Marie E McKeon, Reem H Elbekai
Tg.rasH2 mice are predisposed to hemangiosarcomas. Following the spleen, the uterus is the second most commonly affected organ in the female mice. Female mice are also predisposed to spontaneous vascular proliferative lesions on the serosal surface of the uterus, in which there is proliferation of normal vessels that are lined by well-differentiated endothelial cells. The hemangiosarcomas and vascular proliferative lesions can occur independently. In our facility, we have recorded a total of 47 uterine hemangiosarcomas in 3,985 female Tg...
July 20, 2016: International Journal of Toxicology
https://www.readbyqxmd.com/read/27422008/identification-of-the-two-kit-isoforms-and-their-expression-status-in-canine-hemangiosarcomas
#14
Yi-Chen Chen, Jiunn-Wang Liao, Wei-Li Hsu, Shih-Chieh Chang
BACKGROUND: KIT is a tyrosine kinase growth factor receptor. High expression of KIT has been found in several tumors including canine hemangiosarcoma (HSA). This study investigated the correlation of KIT expression and c-kit sequence mutations in canine HSAs and benign hemangiomas (HAs). RESULTS: Immunohistochemistry (IHC) staining confirmed KIT expression in 94.4 % (34/36) of HSAs that was significantly higher than 0 % in HAs (0/16). Sequencing the entire c-kit coding region of HSAs and normal canine cerebellums (NCCs) revealed GNSK-deletion in exon 9...
2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27408334/effects-of-inhibitors-of-vascular-endothelial-growth-factor-receptor-2-and-downstream-pathways-of-receptor-tyrosine-kinases-involving-phosphatidylinositol-3-kinase-akt-mammalian-target-of-rapamycin-or-mitogen-activated-protein-kinase-in-canine-hemangiosarcoma
#15
Mami Adachi, Yuki Hoshino, Yusuke Izumi, Hiroki Sakai, Satoshi Takagi
Canine hemangiosarcoma (HSA) is a progressive malignant neoplasm with no current effective treatment. Previous studies showed that receptor tyrosine kinases and molecules within their downstream pathways involving phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (m-TOR) or mitogen-activated protein kinase (MAPK) were overexpressed in canine, human, and murine tumors, including HSA. The present study investigated the effects of inhibitors of these pathways in canine splenic and hepatic HSA cell lines using assays of cell viability and apoptosis...
July 2016: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/27318054/angiosarcoma-after-excisional-surgery-for-chronic-lymphedema
#16
Jin Hyun Joh, Byung-Boong Lee, Young Soo Chun, Weon Kuu Chung, Ha Yeon Lee
Angiosarcoma is a rare soft tissue sarcoma of endothelial cell origin. It can arise from the endothelium of lymphatics (lymphangiosarcoma) or blood vessels (hemangiosarcoma). Chronic lymphedema of any origin is associated with its development. Few cases have been reported after surgical procedures for lymphedema. Here, we report one case of angiosarcoma that developed 15 months after excisional surgery for lymphedema. In spite of radical surgery and adjuvant chemoradiotherapy, the patient died of multiple lung metastases and pleural effusion 13 months later...
July 2016: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/27315383/cutaneous-hemangiosarcoma-in-a-pacific-parrotlet-forpus-coelestis
#17
Zachary F Kline, Julia K Whittington, David A Coleman
A 2-month-old Pacific parrotlet (Forpus coelestis) was presented for assessment following a traumatic injury to the right wing that resulted in persistent swelling and inflammation. Six weeks postinjury the bird underwent surgical resection of a large hemorrhagic cavitated mass that had formed at the site of the original injury and a second, smaller mass on the body in direct contact with the wing mass. Histopathology of the wing mass confirmed a diagnosis of hemangiosarcoma. While commonly diagnosed in domestic species, hemangiosarcoma is uncommonly reported in avian species...
June 2016: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/27298251/disseminated-hemangiosarcoma-in-a-juvenile-rhesus-macaque-macaca-mulatta
#18
Amanda P Beck, Stanton B Gray, Beth K Chaffee
Hemangiosarcoma is a malignant tumor of vascular endothelial origin that is sporadically reported in rhesus macaques. This report describes the clinicopathologic features of a 1-y-old rhesus macaque with spontaneous disseminated hemangiosarcoma that originally presented as a focal cutaneous mass. Histopathologic examination of multiple tumor foci revealed regions in which the neoplastic cells formed diffuse sheets, as well as the well-defined vascular channels typically associated with hemangiosarcoma. Multiple endothelial cell immunomarkers were used to confirm the diagnosis in this rhesus macaque...
2016: Comparative Medicine
https://www.readbyqxmd.com/read/27276060/immunohistochemical-analysis-of-pd-l1-expression-in-canine-malignant-cancers-and-pd-1-expression-on-lymphocytes-in-canine-oral-melanoma
#19
Naoya Maekawa, Satoru Konnai, Tomohiro Okagawa, Asami Nishimori, Ryoyo Ikebuchi, Yusuke Izumi, Satoshi Takagi, Yumiko Kagawa, Chie Nakajima, Yasuhiko Suzuki, Yukinari Kato, Shiro Murata, Kazuhiko Ohashi
Spontaneous cancers are common diseases in dogs. Among these, some malignant cancers such as oral melanoma, osteosarcoma, hemangiosarcoma, and mast cell tumor are often recognized as clinical problems because, despite their high frequencies, current treatments for these cancers may not always achieve satisfying outcomes. The absence of effective systemic therapies against these cancers leads researchers to investigate novel therapeutic modalities, including immunotherapy. Programmed death 1 (PD-1) is a costimulatory receptor with immunosuppressive function...
2016: PloS One
https://www.readbyqxmd.com/read/27259024/occurrence-and-clinicopathologic-features-of-splenic-neoplasia-based-on-body-weight-325-dogs-2003-2013
#20
J Matthew Sherwood, April M Haynes, Emily Klocke, Mary Lynn Higginbotham, Elizabeth M Thomson, Hsin-Yi Weng, Heather A Towle Millard
Medical records of 396 dogs undergoing splenectomy for treatment of a splenic mass or nodular disease were reviewed retrospectively. Overall distribution of histopathologic diagnosis and clinicopathologic features were evaluated for 325 dogs that met inclusion criteria. Dogs were dichotomized into two groups based on weight, with the statistically derived cutoff identified as 27.8 kg. Malignancy was diagnosed in 58% of dogs, with no difference between small (55%) and large (61%) dogs (P = .291). Overall, 32% of splenic masses were hemangiosarcoma (HSA), which comprised 25 and 39% of all masses in small and large dogs, respectively...
July 2016: Journal of the American Animal Hospital Association
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