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hemangiosarcoma

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https://www.readbyqxmd.com/read/28193671/safe-and-effective-sarcoma-therapy-through-bispecific-targeting-of-egfr-and-upar
#1
Antonella Borgatti, Joseph S Koopmeiners, Aaron L Sarver, Amber L Winter, Kathleen Stuebner, Deborah Todhunter, Anthony E Rizzardi, Jonathan C Henricksen, Stephen Schmechel, Colleen L Forster, Jong-Hyuk Kim, Jerry Froelich, Jillian Walz, Michael S Henson, Matthew Breen, Kerstin Lindblad-Toh, Felix Oh, Kristy Pilbeam, Jaime F Modiano, Daniel A Vallera
Sarcomas differ from carcinomas in their mesenchymal origin. Therapeutic advancements have come slowly so alternative drugs and models are urgently needed. These studies report a new drug for sarcomas that simultaneously targets both tumor and tumor neovasculature. eBAT is a bispecific angiotoxin consisting of truncated, deimmunized Pseudomonas exotoxin fused to epidermal growth factor (EGF) and the amino terminal fragment (ATF) of urokinase. Here, we study the drug in an in vivo "ontarget" companion dog trial since eBAT effectively kills canine hemangiosarcoma (HSA) and human sarcoma cells in vitro...
February 13, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28190928/metastatic-hemangiosarcoma-of-the-liver-in-a-young-rat
#2
Makoto Tanaka, Seiji Miyoshi, Osamu Sawamoto
Spontaneous hemangiosarcoma is generally uncommon in rats. Furthermore, there are only a few case reports in young rats. This report describes a spontaneous hemangiosarcoma in a young 7-week-old rat. At necropsy, no remarkable changes were noted in any organs including the liver. Histopathologically, multifocal small tumors were located mainly in the perilobular region of the liver. The tumors comprised polygonal to short spindle-shaped cells that showed cellular atypia and local infiltration. In the foci, there were blood-filled spaces lined by spindle-shaped cells...
January 2017: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/28132405/urethral-stenting-for-obstructive-uropathy-utilizing-digital-radiography-for-guidance-feasibility-and-clinical-outcome-in-26-dogs
#3
A Radhakrishnan
BACKGROUND: Urethral stent placement is an interventional treatment option to alleviate urethral outflow obstruction. It has been described utilizing fluoroscopy, but fluoroscopy is not as readily available in private practice as digital radiography. OBJECTIVES: To describe the use of digital radiography for urethral stent placement in dogs with obstructive uropathy. ANIMALS: Twenty-six client-owned dogs presented for dysuria associated with benign and malignant causes of obstructive uropathy that underwent urethral stent placement...
January 29, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28129857/discovering-novel-oncogenic-pathways-and-new-therapies-using-zebrafish-models-of-sarcoma
#4
M N Hayes, D M Langenau
Sarcoma is a type of cancer affecting connective, supportive, or soft tissue of mesenchymal origin. Despite rare incidence in adults (<1%), over 15% of pediatric cancers are sarcoma. Sadly, both adults and children with relapsed or metastatic disease have devastatingly high rates of mortality. Current treatment options for sarcoma include surgery, radiation, and/or chemotherapy; however, significant limitations exist with respect to the efficacy of these strategies. Strong impetus has been placed on the development of novel therapies and preclinical models for uncovering mechanisms involved in the development, progression, and therapy resistance of sarcoma...
2017: Methods in Cell Biology
https://www.readbyqxmd.com/read/28029283/evaluation-of-procoagulant-tissue-factor-expression-in-canine-hemangiosarcoma-cell-lines
#5
Lauren E Witter, Erika J Gruber, Fabian Z X Lean, Tracy Stokol
OBJECTIVE To evaluate expression of procoagulant tissue factor (TF) by canine hemangiosarcoma cells in vitro. SAMPLES 4 canine hemangiosarcoma cell lines (SB-HSA [mouse-passaged cutaneous tumor], Emma [primary metastatic brain tumor], and Frog and Dal-1 [primary splenic tumors]) and 1 nonneoplastic canine endothelial cell line (CnAoEC). PROCEDURES TF mRNA and TF antigen expression were evaluated by quantitative real-time PCR assay and flow cytometry, respectively. Thrombin generation was measured in canine plasma and in coagulation factor-replete or specific coagulation factor-deficient human plasma by calibrated automated thrombography...
January 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28001112/microwave-ablation-for-treatment-of-hepatic-neoplasia-in-five-dogs
#6
Toni Yang, J Brad Case, Sarah Boston, Michael J Dark, Beau Toskich
CASE DESCRIPTION 5 dogs between 9 and 11 years of age were evaluated for treatment of primary (n = 2) or metastatic (3) hepatic neoplasia. CLINICAL FINDINGS Patients were evaluated on an elective (n = 3) or emergency (2) basis. Two dogs with primary hepatic neoplasia were evaluated because of lethargy and inappetence. One dog was referred after an enlarged anal sac was detected via palpation per rectum during a routine physical examination. Two dogs were evaluated on an emergency basis because of lethargy and weakness, and hemoabdomen in the absence of a history of trauma was detected...
January 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27928170/magnetic-resonance-imaging-and-immunohistochemistry-of-primary-vertebral-hemangiosarcoma-in-a-dog-and-implications-for-diagnosis-and-therapy
#7
Claudia Pérez-Martínez, Marta Regueiro-Purriños, Beatriz Fernández-Martínez, José R Altónaga, José M Gonzalo-Orden, María J García-Iglesias
A vertebral mass in a dog with an acute onset paraparesis was identified by magnetic resonance imaging. A poorly differentiated hemangiosarcoma was diagnosed by histopathology and immunohistochemistry. Endothelial nitric oxide synthase could be a new differential marker for poorly differentiated hemangiosarcoma in dogs. Immunohistochemical detection of p53 phosphorylated at Serine(392), p53, CD117, and CD44 suggest targets for design of therapeutic strategies.
December 2016: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/27912752/a-comparison-of-microrna-expression-profiles-from-splenic-hemangiosarcoma-splenic-nodular-hyperplasia-and-normal-spleens-of-dogs
#8
COMPARATIVE STUDY
Janet A Grimes, Nripesh Prasad, Shawn Levy, Russell Cattley, Stephanie Lindley, Harry W Boothe, Ralph A Henderson, Bruce F Smith
BACKGROUND: Splenic masses are common in older dogs; yet diagnosis preceding splenectomy and histopathology remains elusive. MicroRNAs (miRNAs) are short, non-coding RNAs that play a role in post-transcriptional regulation, and differential expression of miRNAs between normal and tumor tissue has been used to diagnose neoplastic diseases. The objective of this study was to determine differential expression of miRNAs by use of RNA-sequencing in canine spleens that were histologically confirmed as hemangiosarcoma, nodular hyperplasia, or normal...
December 3, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27779362/role-of-monocyte-recruitment-in-hemangiosarcoma-metastasis-in-dogs
#9
D P Regan, A Escaffi, J Coy, J Kurihara, S W Dow
Canine hemangiosarcoma (HSA) is a highly malignant tumour associated with short survival times because of early and widespread metastasis. In humans and rodents, monocytes play key roles in promoting tumour metastasis through stimulating tumour cell extravasation, seeding, growth and angiogenesis. Therefore, we investigated the potential association between monocyte infiltration and tumour metastasis in HSA and other common canine tumours. Immunohistochemistry was used to quantify CD18(+) monocytes within metastases...
October 25, 2016: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/27767434/primary-nodal-hemangiosarcoma-in-four-dogs
#10
Catherine M Chan, Courtney H Zwahlen, Louis-Philippe de Lorimier, Stephen M Yeomans, Karon L Hoffmann, Antony S Moore
CASE DESCRIPTION 4 dogs with a slow-growing mass in the cervical region were evaluated. CLINICAL FINDINGS All dogs had no clinical signs at the time of the evaluation. There was no apparent evidence of visceral metastases or other primary tumor based on available CT or MRI data for any dog. TREATMENT AND OUTCOME For each dog, surgery to remove the mass was performed. Histologic examination of the excised tissue revealed a completely excised grade 1 or 2 lymph node hemangiosarcoma. All dogs received adjuvant chemotherapy; 2 dogs underwent curative intent chemotherapy, 1 dog underwent metronomic treatment with cyclophosphamide, and 1 dog underwent metronomic treatment with chlorambucil...
November 1, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27746404/primary-intrapelvic-hemangiosarcoma-in-a-dog
#11
Saejong Yoo, Jiyong Kim, Hyun-Wook Myung, Suhan Woo, Dai-Jung Chung, A-Jin Lee, Han-Jun Kim, Sun-Hee DO, Hwi-Yool Kim
A 12-year-old, spayed female Schnauzer presented with constipation. A mass was observed in the pelvic cavity, and metastasis was not identified. Mass resection was performed through celiotomy with pubic osteotomy, and hemangiosarcoma was diagnosed. At 10 weeks post-operatively, the patient died of multiple metastasis. Primary intrapelvic hemangiosarcoma is rare in dogs.
January 24, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27699974/imaging-diagnosis-ultrasonographic-appearance-of-skeletal-muscle-metastases-in-a-dog-with-hemangiosarcoma
#12
Martina Fabbi, Stefano Di Palma, Sabrina Manfredi, Giacomo Gnudi, Francesca Miduri, Eleonora Daga, Gabriele Costantino Melis, Ezio Bianchi, Simone Voccia, Antonella Volta
A 13-year-old spayed female German shepherd dog was presented for acute onset of lethargy, anorexia, and disseminated erythematous skin lesions. Thoracic radiographs and abdominal ultrasonographic findings were consistent with metastatic hemangiosarcoma. Multiple, ill-defined, irregularly shaped hypoechoic nodules were also detected within the thoracic and abdominal wall. Hemangiosarcoma metastases to the skeletal muscle were confirmed based on histopathological examination. Multivisceral involvement was also confirmed by necropsy...
October 4, 2016: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/27677669/glyphosate-rodent-carcinogenicity-bioassay-expert-panel-review
#13
Gary M Williams, Colin Berry, Michele Burns, Joao Lauro Viana de Camargo, Helmut Greim
Glyphosate has been rigorously and extensively tested for carcinogenicity by administration to mice (five studies) and to rats (nine studies). Most authorities have concluded that the evidence does not indicate a cancer risk to humans. The International Agency for Research on Cancer (IARC), however, evaluated some of the available data and concluded that glyphosate probably is carcinogenic to humans. The expert panel convened by Intertek assessed the findings used by IARC, as well as the full body of evidence and found the following: (1) the renal neoplastic effects in males of one mouse study are not associated with glyphosate exposure, because they lack statistical significance, strength, consistency, specificity, lack a dose-response pattern, plausibility, and coherence; (2) the strength of association of liver hemangiosarcomas in a different mouse study is absent, lacking consistency, and a dose-response effect and having in high dose males only a significant incidence increase which is within the historical control range; (3) pancreatic islet-cell adenomas (non-significant incidence increase), in two studies of male SD rats did not progress to carcinomas and lacked a dose-response pattern (the highest incidence is in the low dose followed by the high dose); (4) in one of two studies, a non-significant positive trend in the incidence of hepatocellular adenomas in male rats did not lead to progression to carcinomas; (5) in one of two studies, the non-significant positive trend in the incidence of thyroid C-cell adenomas in female rats was not present and there was no progression of adenomas to carcinomas at the end of the study...
September 2016: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/27585244/alternative-lengthening-of-telomeres-does-exist-in-various-canine-sarcomas
#14
Theresa Kreilmeier, Sandra Sampl, Abigail J Deloria, Ingrid Walter, Martin Reifinger, Marlene Hauck, Luke B Borst, Klaus Holzmann, Miriam Kleiter
Alternative lengthening of telomeres (ALT) is a telomere maintenance mechanism (TMM) found in some human tumors such as sarcomas. Canine tumors are not characterized for ALT and the study aim was to identify if the ALT phenotype exists in canine sarcomas. Sixty-four canine sarcoma samples (20 snap-frozen, 44 FFPE) as well as six canine sarcoma cell lines were screened for ALT by C-circle assay. ALT was further evaluated by measuring telomere length via qPCR and telomere restriction-fragments including pulsed-field electrophoresis...
March 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/27528400/fischer-344-tp53-knockout-rats-exhibit-a-high-rate-of-bone-and-brain-neoplasia-with-frequent-metastasis
#15
Sarah A Hansen, Marcia L Hart, Susheel Busi, Taybor Parker, Angela Goerndt, Kevin Jones, James M Amos-Landgraf, Elizabeth C Bryda
Somatic mutations in the Tp53 tumor suppressor gene are the most commonly seen genetic alterations in cancer, and germline mutations in Tp53 predispose individuals to a variety of early-onset cancers. Development of appropriate translational animal models that carry mutations in Tp53 and recapitulate human disease are important for drug discovery, biomarker development and disease modeling. Current Tp53 mouse and rat models have significant phenotypic and genetic limitations, and often do not recapitulate certain aspects of human disease...
October 1, 2016: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/27507032/use-of-routine-histopathology-and-factor-viii-related-antigen-von-willebrand-factor-immunohistochemistry-to-differentiate-primary-hemangiosarcoma-of-bone-from-telangiectatic-osteosarcoma-in-54-dogs
#16
M A Giuffrida, N J Bacon, D A Kamstock
Hemangiosarcoma (HSA) of bone and telangiectatic osteosarcoma (tOSA) can appear similar histologically, but differ in histogenesis (malignant endothelial cells versus osteoblasts), and may warrant different treatments. Immunohistochemistry (IHC) for endothelial cell marker factor VIII-related antigen/von Willebrand factor (FVIII-RAg/vWF) is a well-documented ancillary test to confirm HSA diagnoses in soft tissues, but its use in osseous HSA is rarely described. Archived samples of 54 primary appendicular bone tumours previously diagnosed as HSA or tOSA were evaluated using combination routine histopathology (RHP) and IHC...
August 9, 2016: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/27493283/outcome-and-prognostic-factors-for-dogs-with-a-histological-diagnosis-of-splenic-hematoma-following-splenectomy-35-cases-2001-2013
#17
Steve G Patten, Sarah E Boston, Gabrielle J Monteith
Canine splenic hematoma can be indistinguishable from hemangiosarcoma on clinical presentation and grossly at the time of surgery. However, hemangiosarcoma represents an aggressive malignancy and a misdiagnosis of hematoma would forgo indications for chemotherapy. This study describes a long-term follow-up of cases with a histologic diagnosis of splenic hematoma following splenectomy to determine if the clinical course of the disease corroborated the diagnosis. Thirty-five dogs were evaluated to determine survival and prognostic associations with signalment and clinical data...
August 2016: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/27487352/hemothorax-in-three-dogs-with-intrathoracic-extracardiac-hemangiosarcoma
#18
Lynda Rutherford, Anneliese Stell, Ken Smith, Nicola Kulendra
Intrathoracic extracardiac hemangiosarcoma (HSA) is rare in dogs. This report describes three dogs with acute onset dyspnea due to hemorrhagic pleural effusion resulting from intrathoracic extracardiac masses, which were confirmed as HSA by histopathology. The dogs were stabilized with thoracocentesis and intravascular fluid resuscitation. Computed tomography identified intrathoracic masses, which were not originating from the heart or pulmonary parenchyma. Surgical exploration was performed in all cases. Case 1 was euthanized intraoperatively as the tumor could not be dissected from the aorta...
September 2016: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/27456773/stage-specific-embryonic-antigen-ssea-determining-the-expression-in-canine-glioblastoma-melanoma-and-mammary-cancer-cells
#19
Weiming Lin, Jaime F Modiano, Daisuke Ito
The expression of stage-specific embryonic antigens (SSEAs) was determined in multiple canine cancer cells. Flow cytometry showed SSEA-1 expression in glioblastoma, melanoma and mammary cancer cells, although none expressed SSEA-3 or SSEA-4. SSEA-1 expression was not detectable in lymphoma, osteosarcoma, or hemangiosarcoma cell lines. Relatively stable SSEA-1 expression was observed after 24, 48 and 72 h of culture, and sorted SSEA-1(-) and SSEA-1(+) cells following 8-days in culture re-established comparable expression levels of SSEA-1 as were seen in unsorted cells...
July 25, 2016: Journal of Veterinary Science
https://www.readbyqxmd.com/read/27440821/progression-of-serosal-vascular-proliferative-lesions-to-hemangiosarcomas-in-the-uterus-of-the-26-week-tg-rash2-mice-carcinogenicity-studies
#20
Madhav G Paranjpe, Jessica L Belich, Dayauna R Richardson, Tom Vidmar, Peter C Mann, Marie E McKeon, Reem H Elbekai
Tg.rasH2 mice are predisposed to hemangiosarcomas. Following the spleen, the uterus is the second most commonly affected organ in the female mice. Female mice are also predisposed to spontaneous vascular proliferative lesions on the serosal surface of the uterus, in which there is proliferation of normal vessels that are lined by well-differentiated endothelial cells. The hemangiosarcomas and vascular proliferative lesions can occur independently. In our facility, we have recorded a total of 47 uterine hemangiosarcomas in 3,985 female Tg...
July 20, 2016: International Journal of Toxicology
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