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diastolic dysfunction in cirrhotics

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https://www.readbyqxmd.com/read/27931578/pretransplant-left-ventricular-dysfunction-adversely-affects-perioperative-outcomes-in-pediatric-liver-transplantation-a%C3%A2-retrospective-observational-study
#1
D-M Jang, I-G Jun, Y-J Moon, W-J Shin, J-G Song, G-S Hwang
BACKGROUND: Although left ventricular diastolic dysfunction (LVDD) is a pronounced feature of adult cirrhotic cardiomyopathy and a major predictor of poor outcomes following liver transplantation (LT), little is known about if pretransplant cardiac dysfunction affects perioperative outcomes in pediatric LT. METHODS: We retrospectively evaluated pretransplant clinical and Doppler echocardiographic data for 45 consecutive pediatric LT recipients who were treated between 2007 and 2013 (median age = 15 months; interquartile range = 9 to 78 months)...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27816131/anesthesia-patients-with-concomitant-cardiac-and-hepatic-dysfunction
#2
REVIEW
Julianne Ahdout, Michael Nurok
Anesthesia and surgery in patients with hepatic and cardiac dysfunction poses a challenge for anesthesiologists. It is imperative to optimize these patients perioperatively. Cirrhosis is associated with a wide range of cardiovascular abnormalities. Cirrhotic cardiomyopathy is characterized by blunted contractile responsiveness or systolic incompetence, and/or diastolic dysfunction. In liver disease, anesthetic drug distribution, metabolism, and elimination may be altered. Among patients with liver disease, propofol is a reasonable anesthetic choice and cisatracurium is the preferred neuromuscular blocker...
December 2016: Anesthesiology Clinics
https://www.readbyqxmd.com/read/27458853/galactin-3-and-brain-natriuretic-peptide-versus-conventional-echocardiography-in-the-early-detection-of-cirrhotic-cardiomyopathy
#3
Wael A Abbas, Soheir M Kasem Ahmed, Amal M Abdel Aal, Amal A Mahmoud, Mohamed O Abdelmalek, Mohamed A Mekky, Mohamed A A Abozaid, Ahmed K Ibrahim
BACKGROUND/AIMS: Cirrhotic cardiomyopathy (CCM) is defined as an abnormal heart structure and function in cirrhotic patients. CCM includes systolic and diastolic dysfunction, electrophysiological abnormalities, and structural changes, both microscopic and macroscopic. Currently, there is no one diagnostic test that can identify patients with CCM. Evaluation of the validity of galactin-3 and brain natriuretic peptide (BNP) as biomarkers in the early detection of CCM in comparison to conventional echocardiography...
July 2016: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/27214985/-diagnosis-and-clinical-manifestations-of-cirrhotic-cardiomyopathy
#4
A S Rodina, M E Shubina, O P Dudanova
UNLABELLED: The aim of the study was to determine the incidence of cirrhotic cardiomyopathy (CCMP), features of its recognition and clinical manifestations. MATERIALS AND METHODS: The study included 102 patients with alcoholic and viral liver cirrhosis (LC) without cardiovascular history, without viremia and signs of acute alcoholic hepatitis. Echocardiography, electrocardiography (ECG) and brain natriuretic hormone (proBNP) level were investigated in all patients...
2015: Experimental & Clinical Gastroenterology
https://www.readbyqxmd.com/read/27075496/diastolic-dysfunction-in-cirrhosis
#5
Søren Møller, Signe Wiese, Hanne Halgreen, Jens D Hove
Development of esophageal varices, ascites, and hepatic nephropathy is among the major complications of cirrhosis. The presence of cirrhotic cardiomyopathy, which includes a left ventricular diastolic dysfunction (DD), seems to deteriorate the course of the disease and the prognosis. Increased stiffness of the cirrhotic heart may decrease the compliance and result in DD. The prevalence of DD in cirrhotic patients averages about 50 %. It can be evaluated by transmitral Doppler echocardiography, tissue Doppler echocardiography, and cardiac magnetic resonance imaging...
September 2016: Heart Failure Reviews
https://www.readbyqxmd.com/read/27011687/evaluation-of-cardiac-functions-of-cirrhotic-children-using-serum-brain-natriuretic-peptide-and-tissue-doppler-imaging
#6
Aya M Fattouh, Mortada H El-Shabrawi, Enas H Mahmoud, Wafaa O Ahmed
BACKGROUND: Cirrhotic cardiomyopathy (CCM) is described as the presence of cardiac dysfunction in cirrhotic patients. In children with chronic liver disease, CCM has been very rarely investigated. THE AIM OF THE STUDY: Is to evaluate the cardiac function of cirrhotic children to identify those with CCM. PATIENTS AND METHODS: Fifty-two cirrhotic patients and 53 age and sex matched controls were assessed using serum brain-type natriuretic peptide (BNP), conventional echocardiography, and tissue Doppler imaging...
January 2016: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/26915857/diastolic-dysfunction-in-liver-cirrhosis-prognostic-predictor-in-liver-transplantation
#7
F Carvalheiro, C Rodrigues, T Adrego, J Viana, H Vieira, C Seco, L Pereira, F Pinto, A Eufrásio, C Bento, E Furtado
BACKGROUND: Patients with liver cirrhosis may develop cirrhotic cardiomyopathy (CC), characterized by blunted contractile responsiveness to stress, diastolic dysfunction (DD), and electrophysiological abnormalities. It may adversely affect the long-term prognosis of these patients. METHODS: We conducted a retrospective analysis of patients undergoing liver transplantation (LT) for cirrhosis from January 2012 to June 2015. We analyzed demographic characteristics, the etiology of cirrhosis, Child-Pugh and Model for End-Stage Liver Disease (MELD) scores, the corrected QT (QTc) interval in the preoperative period, diastolic and systolic dysfunction, mortality and survival, and duration of mechanical ventilation and vasopressor support in the post-LT period...
January 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/26850503/cardiac-manifestations-in-alcoholic-liver-disease
#8
REVIEW
Sandra Milić, Davorka Lulić, Davor Štimac, Alen Ružić, Luka Zaputović
Alcoholic liver disease is the most prevalent cause of progressive liver disease in Europe. Alcoholic cirrhosis occurs in 8%-20% of cases of alcoholic liver disease. It has significant influence on cardiovascular system and haemodynamics through increased heart rate, cardiac output, decreased systemic vascular resistance, arterial pressure and plasma volume expansion. Cirrhotic cardiomyopathy is characterised by systolic and diastolic dysfunction and electrophysiological abnormalities, if no other underlying cardiac disease is present...
April 2016: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/26839643/cirrhotic-cardiomyopathy-isn-t-stress-evaluation-always-required-for-the-diagnosis
#9
Mara Barbosa, Joana Guardado, Carla Marinho, Bruno Rosa, Isabel Quelhas, António Lourenço, José Cotter
AIM: To describe the proportion of patients with cirrhotic cardiomyopathy (CCM) evaluated by stress echocardiography and investigating its association with the severity of liver disease. METHODS: A cross-sectional study was conducted. Cirrhotic patients without risk factors for cardiovascular disease were included. Data regarding etiology and severity of liver disease (Child-Pugh score and model for end-stage liver disease), presence of ascites and gastroesophageal varices, pro-brain natriuretic peptide (pro-BNP) and corrected QT (QTc) interval were collected...
January 28, 2016: World Journal of Hepatology
https://www.readbyqxmd.com/read/26755864/left-ventricular-function-assessment-in-cirrhosis-current-methods-and-future-directions
#10
REVIEW
Francisco Sampaio, Joana Pimenta
Cirrhotic cardiomyopathy has been defined as a chronic cardiac dysfunction in patients with cirrhosis characterized by impaired contractile responsiveness to stress and/or altered diastolic relaxation with electrophysiological abnormalities in the absence of other known cardiac disease. Non-invasive cardiovascular imaging modalities play a major role in unmasking systolic and diastolic dysfunction in patients with cirrhosis. Echocardiography has been the most commonly used modality for assessing myocardial function in these patients...
January 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26556983/cirrhotic-cardiomyopathy
#11
REVIEW
Luis Ruiz-del-Árbol, Regina Serradilla
During the course of cirrhosis, there is a progressive deterioration of cardiac function manifested by the disappearance of the hyperdynamic circulation due to a failure in heart function with decreased cardiac output. This is due to a deterioration in inotropic and chronotropic function which takes place in parallel with a diastolic dysfunction and cardiac hypertrophy in the absence of other known cardiac disease. Other findings of this specific cardiomyopathy include impaired contractile responsiveness to stress stimuli and electrophysiological abnormalities with prolonged QT interval...
November 7, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26545992/evaluation-of-cardiac-systolic-function-in-cirrhotic-patients-undergoing-liver-transplantation
#12
Roya Sattarzadeh-Badkoubeh, Babak Geraiely, Mohssen Nassiri-Toosi, Ali Jafarian
We assessed different systolic cardiac indices to detect left and right ventricular systolic dysfunction in cirrhotic patients before liver transplantation. Between 2010-2011, 81 consecutive individuals with confirmed hepatic cirrhosis who were a candidate for liver transplantation were enrolled in this study. A total of 32 age and sex matched healthy volunteers were also selected as the control group. A detailed two-dimensional, Color Flow Doppler, and Tissue Doppler echocardiography were performed in all patients and control participants...
August 2015: Acta Medica Iranica
https://www.readbyqxmd.com/read/26541640/cardiac-imaging-in-patients-with-chronic-liver-disease
#13
Signe Wiese, Jens D Hove, Søren Møller
Cirrhotic cardiomyopathy (CCM) is characterized by an impaired contractile response to stress, diastolic dysfunction and the presence of electrophysiological abnormalities, and it may be diagnosed at rest in some patients or demasked by physiological or pharmacological stress. CCM seems to be involved in the development of hepatic nephropathy and is associated with an impaired survival. In the field of cardiac imaging, CCM is not yet a well-characterized entity, hence various modalities of cardiac imaging have been applied...
November 5, 2015: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/26525531/diastolic-dysfunction-diagnosed-by-tissue-doppler-imaging-in-cirrhotic-patients-prevalence-and-its-possible-relationship-with-clinical-outcome
#14
Calogero Falletta, Daniela Filì, Cinzia Nugara, Gabriele Di Gesaro, Chiara Minà, Cesar Mario Hernandez Baravoglia, Giuseppe Romano, Cesare Scardulla, Fabio Tuzzolino, Giovanni Vizzini, Francesco Clemenza
BACKGROUND: Cirrhotic cardiomyopathy has been characterized by impaired contractile response to stress and/or altered diastolic relaxation, with electrophysiological abnormalities in the absence of known cardiac disease. However, the clinical significance of diastolic dysfunction (DDF) in cirrhotic patients has not been clarified. METHODS: We studied 84 cirrhotic patients with normal systolic function to evaluate the prevalence of DDF using tissue Doppler imaging, and to investigate the possible correlation of DDF with outcomes (hospitalization, death) and with the specific causes of death...
December 2015: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/26462482/cardiac-abnormalities-in-cirrhotic-children-pre-and-post-liver-transplantation
#15
Khemika Khemakanok, Anant Khositseth, Suporn Treepongkaruna, Sumate Teeraratkul, Wichai Pansrimangkorn, Surasak Leelaudomlipi, Uthen Bunmee, Suthus Sriphojanart
BACKGROUND/AIM: Liver cirrhosis is associated with several cardiac abnormalities. There have been few studies of these abnormalities in cirrhotic children post-liver transplantation (LT). The purpose of this study was to evaluate cardiac abnormalities in cirrhotic children pre- and post-LT. METHODS: All cirrhotic children <15 years of age on a waiting list for LT underwent pre-LT echocardiography to evaluate left ventricular (LV) dimension, mass, and function...
May 2016: Hepatology International
https://www.readbyqxmd.com/read/26427586/circulatory-response-to-volume-expansion-and-transjugular-intrahepatic-portosystemic-shunt-in-refractory-ascites-relationship-with-diastolic-dysfunction
#16
Daniela Filì, Calogero Falletta, Angelo Luca, Cesar Hernandez Baravoglia, Francesco Clemenza, Roberto Miraglia, Cesare Scardulla, Fabio Tuzzolino, Giovanni Vizzini, Bruno Gridelli, Jaime Bosch
BACKGROUND: Cirrhotic cardiomyopathy may lead to heart failure in stressful circumstances, such as after transjugular intrahepatic portosystemic shunt (TIPS) placement. AIM: To examine whether acute volume expansion predicts haemodynamic changes after TIPS and elicits signs of impending heart failure. METHODS: We prospectively evaluated refractory ascites patients (group A) and compensated cirrhotics (group B), who underwent echocardiography, NT-proBNP measurement, and heart catheterization before and after volume load; group A repeated measurements after TIPS...
December 2015: Digestive and Liver Disease
https://www.readbyqxmd.com/read/26304615/a-detailed-evaluation-of-cardiac-function-in-cirrhotic-patients-and-its-alteration-with-or-without-liver-transplantation
#17
Yan Chen, Albert C Chan, See-Ching Chan, Siu-Ho Chok, William Sharr, James Fung, Ju-Hua Liu, Zhe Zhen, Wai-Ching Sin, Chung-Mau Lo, Hung-Fat Tse, Kai-Hang Yiu
BACKGROUND: Cirrhosis has been shown to be associated with left ventricular (LV) myocardial dysfunction, but studies of right ventricular (RV) function in cirrhotic patients compared with controls are scarce. Limited studies have prospectively evaluated the progression of myocardial function in patients with cirrhosis and assessed changes in cardiac function following liver transplantation (LTx). So the aim of the study was to evaluate biventricular myocardial function in cirrhotic patients and its alteration with or without liver transplantation...
February 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/26202764/diastolic-cardiac-dysfunction-is-a-predictor-of-dismal-prognosis-in-patients-with-liver-cirrhosis
#18
Dimitrios S Karagiannakis, Jiannis Vlachogiannakos, Georgios Anastasiadis, Irini Vafiadis-Zouboulis, Spiros D Ladas
BACKGROUND AND PURPOSE: Left ventricular diastolic dysfunction (LVDD) constitutes the prominent characteristic of cirrhotic cardiomyopathy, but its relevance on the clinical course of cirrhotic patients has not been clearly defined. The aim of the study was to evaluate the relationship of LVDD with the severity and etiology of liver disease and to investigate whether it affects the outcome of cirrhotic patients. METHODS: Cardiac function of 45 cirrhotics was studied by a tissue Doppler imaging echocardiography...
October 2014: Hepatology International
https://www.readbyqxmd.com/read/26065511/cardiac-involvement-in-patients-with-cirrhosis-a-focus-on-clinical-features-and-diagnosis
#19
REVIEW
Anna Licata, Giuseppina Novo, Daniela Colomba, Antonino Tuttolomondo, Massimo Galia, Calogero Camma'
Cirrhotic heart has been traditionally considered protected from cardiovascular disease, even if a large amount of literature has recently shown that patients affected by chronic liver disease are exposed to cardiovascular events, as well. Since the first recognition of cardiac involvement in cirrhosis, all published studies explain that decompensated cirrhotic patients suffer from haemodynamic changes, currently known as hyperdynamic syndrome, which finally lead to cirrhotic cardiomyopathy. This is defined by the presence of a subclinical systolic dysfunction unmasked under stress conditions, impaired diastolic function and electrophysiological abnormalities, in the absence of any known cardiac disease...
January 2016: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/26011993/-cirrhotic-cardiomyopathy-a-brief-overview
#20
REVIEW
S Marchetta, J Delwaide, R Lancellotti
Even though cardiac disorders were described in alcoholic cirrhosis more than fifty years ago, cirrhotic cardiomyopathy was not defined until the end of the eighties. The term is used to describe all the cardiac structural and functional abnormalities observed in cirrhotic patients without any underlying cardiac disease. This cardiomyopathy is characterized by impaired systolic function, often unmasked during stress, diastolic dysfunction, and electrophysiological abnormalities. It can be detected by the electrocardiogram, transthoracic echocardiography and measurements of cardiac biomarkers (BNP)...
February 2015: Revue Médicale de Liège
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