keyword
https://read.qxmd.com/read/38536507/oxaloacetate-as-new-inducer-for-osteogenic-differentiation-of-human-adipose-tissue-derived-mesenchymal-stem-cells-in-vitro
#1
JOURNAL ARTICLE
Fatemeh Jamali Shirkoohi, Marzieh Ghollasi, Raheleh Halabian, Elahe Eftekhari, Mohsen Ghiasi
BACKGROUND: Mitochondrial organelles play a crucial role in cellular metabolism so different cell types exhibit diverse metabolic and energy demands. Therefore, alternations in the intracellular distribution, quantity, function, and structure of mitochondria are required for stem cell differentiation. Finding an effective inducer capable of modulating mitochondrial activity is critical for the differentiation of specific stem cells into osteo-like cells for addressing issues related to osteogenic disorders...
March 27, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38535187/comparative-transcriptome-profiles-of-the-response-of-mycelia-of-the-genus-morchella-to-temperature-stress-an-examination-of-potential-resistance-mechanisms
#2
JOURNAL ARTICLE
Yihong Yue, Haibo Hao, Qian Wang, Tingting Xiao, Yuchen Zhang, Hui Chen, Jinjing Zhang
Temperature and moisture belong to the most important environmental factors affecting the growth and development of fungi. However, the effect of temperature on the mycelia of the edible Morchella mushrooms has not been determined. Here, a comprehensive analysis was performed to determine the influence of culture temperature on 13 strains of mycelia of three Morchella species ( Morchella sextelata , Morchella septimelata , and Morchella importuna ) at 5 °C, 10 °C, 15 °C, 20 °C, 25 °C, and 30 °C...
February 27, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38534780/effects-of-rpl1001-gene-deletion-on-cell-division-of-fission-yeast-and-its-molecular-mechanism
#3
JOURNAL ARTICLE
Wen Yu, Rongmei Yuan, Mengnan Liu, Ke Liu, Xiang Ding, Yiling Hou
The rpl1001 gene encodes 60S ribosomal protein L10, which is involved in intracellular protein synthesis and cell growth. However, it is not yet known whether it is involved in the regulation of cell mitosis dynamics. This study focuses on the growth, spore production, cell morphology, the dynamics of microtubules, chromosomes, actin, myosin, and mitochondria of fission yeast ( Schizosaccharomyces pombe ) to investigate the impact of rpl1001 deletion on cell mitosis. RNA-Seq and bioinformatics analyses were also used to reveal key genes, such as hsp16 , mfm1 and isp3 , and proteasome pathways...
March 18, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534379/disulfiram-inhibits-opsonin-independent-phagocytosis-and-migration-of-human-long-lived-in-vitro-cultured-phagocytes-from-multiple-inflammatory-diseases
#4
JOURNAL ARTICLE
Chen Li, Julian M Schneider, E Marion Schneider
Disulfiram (DSF), an anti-alcoholism medicine, exerts treatment effects in patients suffering from persistent Borreliosis and also exhibits anti-cancer effects through its copper chelating derivatives and induction of oxidative stress in mitochondria. Since chronic/persistent borreliosis is characterized by increased amounts of pro-inflammatory macrophages, this study investigated opsonin-independent phagocytosis, migration, and surface marker expression of in vivo activated and in vitro cultured human monocyte-derived phagocytes (macrophages and dendritic cells) with and without DSF treatment...
March 18, 2024: Cells
https://read.qxmd.com/read/38534330/cannabidiol-disrupts-mitochondrial-respiration-and-metabolism-and-dysregulates-trophoblast-cell-differentiation
#5
JOURNAL ARTICLE
Tina Podinic, Louise Limoges, Cristina Monaco, Andie MacAndrew, Mahek Minhas, Joshua Nederveen, Sandeep Raha
Trophoblast differentiation is a crucial process in the formation of the placenta where cytotrophoblasts (CTs) differentiate and fuse to form the syncytiotrophoblast (ST). The bioactive components of cannabis, such as Δ9 -THC, are known to disrupt trophoblast differentiation and fusion, as well as mitochondrial dynamics and respiration. However, less is known about the impact of cannabidiol (CBD) on trophoblast differentiation. Due to the central role of mitochondria in stem cell differentiation, we evaluated the impact of CBD on trophoblast mitochondrial function and differentiation...
March 11, 2024: Cells
https://read.qxmd.com/read/38521844/diverse-functions-of-cytochrome-c-in-cell-death-and-disease
#6
REVIEW
Zhuan Zhou, Tasnim Arroum, Xu Luo, Rui Kang, Yong J Lee, Daolin Tang, Maik Hüttemann, Xinxin Song
The redox-active protein cytochrome c is a highly positively charged hemoglobin that regulates cell fate decisions of life and death. Under normal physiological conditions, cytochrome c is localized in the mitochondrial intermembrane space, and its distribution can extend to the cytosol, nucleus, and extracellular space under specific pathological or stress-induced conditions. In the mitochondria, cytochrome c acts as an electron carrier in the electron transport chain, facilitating adenosine triphosphate synthesis, regulating cardiolipin peroxidation, and influencing reactive oxygen species dynamics...
March 23, 2024: Cell Death and Differentiation
https://read.qxmd.com/read/38519771/mitophagy-mediated-by-bnip3-and-nix-protects-against-ferroptosis-by-downregulating-mitochondrial-reactive-oxygen-species
#7
JOURNAL ARTICLE
Shun-Ichi Yamashita, Yuki Sugiura, Yuta Matsuoka, Rae Maeda, Keiichi Inoue, Kentaro Furukawa, Tomoyuki Fukuda, David C Chan, Tomotake Kanki
Mitophagy plays an important role in the maintenance of mitochondrial homeostasis and can be categorized into two types: ubiquitin-mediated and receptor-mediated pathways. During receptor-mediated mitophagy, mitophagy receptors facilitate mitophagy by tethering the isolation membrane to mitochondria. Although at least five outer mitochondrial membrane proteins have been identified as mitophagy receptors, their individual contribution and interrelationship remain unclear. Here, we show that HeLa cells lacking BNIP3 and NIX, two of the five receptors, exhibit a complete loss of mitophagy in various conditions...
March 22, 2024: Cell Death and Differentiation
https://read.qxmd.com/read/38519718/oestradiol-and-osteoclast-differentiation-effects-on-p53-and-mitochondrial-metabolism
#8
JOURNAL ARTICLE
Adriana Marques-Carvalho, Beatriz Silva, Francisco B Pereira, Ha-Neui Kim, Maria Almeida, Vilma A Sardão
BACKGROUND: Oestrogen deficiency increases bone resorption, contributing to osteoporosis development. Yet, the mechanisms mediating the effects of oestrogen on osteoclasts remain unclear. This study aimed to elucidate the early metabolic alteration induced by RANKL, the essential cytokine in osteoclastogenesis and 17-beta-oestradiol (E2 ) on osteoclast progenitor cells, using RAW 264.7 macrophage cell line and primary bone marrow-derived macrophages as biological models. RESULTS: This research demonstrated that, in osteoclast precursors, RANKL stimulates complex I activity, oxidative phosphorylation (OXPHOS) and mitochondria-derived ATP production as early as 3 h of exposure...
March 22, 2024: European Journal of Clinical Investigation
https://read.qxmd.com/read/38519473/defective-mitochondria-remodelling-in-b-cells-leads-to-an-aged-immune-response
#9
JOURNAL ARTICLE
Marta Iborra-Pernichi, Jonathan Ruiz García, María Velasco de la Esperanza, Belén S Estrada, Elena R Bovolenta, Claudia Cifuentes, Cristina Prieto Carro, Tamara González Martínez, José García-Consuegra, María Fernanda Rey-Stolle, Francisco Javier Rupérez, Milagros Guerra Rodriguez, Rafael J Argüello, Sara Cogliati, Fernando Martín-Belmonte, Nuria Martínez-Martín
The B cell response in the germinal centre (GC) reaction requires a unique bioenergetic supply. Although mitochondria are remodelled upon antigen-mediated B cell receptor stimulation, mitochondrial function in B cells is still poorly understood. To gain a better understanding of the role of mitochondria in B cell function, here we generate mice with B cell-specific deficiency in Tfam, a transcription factor necessary for mitochondrial biogenesis. Tfam conditional knock-out (KO) mice display a blockage of the GC reaction and a bias of B cell differentiation towards memory B cells and aged-related B cells, hallmarks of an aged immune response...
March 22, 2024: Nature Communications
https://read.qxmd.com/read/38518837/engrailed-1-deficiency-induces-changes-in-ciliogenesis-during-human-neuronal-differentiation
#10
JOURNAL ARTICLE
Sina Hembach, Sebastian Schmidt, Tanja Orschmann, Ingo Burtscher, Heiko Lickert, Florian Giesert, Daniela Vogt Weisenhorn, Wolfgang Wurst
A key pathological feature of Parkinson's Disease (PD) is the progressive degeneration of dopaminergic neurons (DAns) in the substantia nigra pars compacta. Considering the major role of EN1 in the development and maintenance of these DAns and the implications from En1 mouse models, it is highly interesting to study the molecular and protective effect of EN1 also in a human cellular model. Therefore, we generated EN1 knock-out (ko) human induced pluripotent stem cell (hiPSCs) lines and analyzed these during neuronal differentiation...
March 20, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38512537/sirt3-a-potential-target-of-different-types-of-osteoporosis
#11
REVIEW
Binjing Pan, Chongyang Chen, Yangting Zhao, Jing Cai, Songbo Fu, Jingfang Liu
Osteoporosis (OP) is a common age-related disease. OP is mainly a decrease in bone density and mass caused by the destruction of bone microstructure, which leads to an increase in bone fragility. SIRT3 is a mitochondrial deacetylase that plays critical roles in mitochondrial homeostasis, metabolic regulation, gene transcription, stress response, and gene stability. Studies have shown that the higher expression levels of SIRT3 are associated with decreased levels of oxidative stress in the body and may play important roles in the prevention of age-related diseases...
March 21, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38506772/effects-of-mitochondrial-transplantation-on-chronic-pressure-wound-healing-in-a-human-patient
#12
JOURNAL ARTICLE
Omer Faruk Taner, Oner Ulger, Simay Ersahin, Nesrin Tan Baser, Onur Genc, Gokhan Burcin Kubat
BACKGROUND AIMS: Wound healing is a multistage process that requires a concerted effort of various cell types. The intricate processes involved in the healing of wounds result in high energy requirements. Furthermore, mitochondria play a crucial role in the healing process because of their involvement in neo angiogenesis, growth factor synthesis, and cell differentiation. It is unclear how mitochondria transplantation, a promising new approach, influences wound healing. METHODS: In this study, healthy autologous mitochondria obtained from skeletal muscle were injected into chronic pressure wounds as an intervention to promote wound healing...
March 4, 2024: Cytotherapy
https://read.qxmd.com/read/38505645/alterations-in-metabolic-pathways-a-bridge-between-aging-and-weaker-innate-immune-response
#13
REVIEW
Zahra Saleh, Sara Mirzazadeh, Fatemeh Mirzaei, Kamran Heidarnejad, Seppo Meri, Kurosh Kalantar
Aging is a time-dependent progressive physiological process, which results in impaired immune system function. Age-related changes in immune function increase the susceptibility to many diseases such as infections, autoimmune diseases, and cancer. Different metabolic pathways including glycolysis, tricarboxylic acid cycle, amino acid metabolism, pentose phosphate pathway, fatty acid oxidation and fatty acid synthesis regulate the development, differentiation, and response of adaptive and innate immune cells...
2024: Front Aging
https://read.qxmd.com/read/38505613/npc1-is-required-for-postnatal-islet-%C3%AE-cell-differentiation-by-maintaining-mitochondria-turnover
#14
JOURNAL ARTICLE
Bei Liu, Duanyi Hua, Linyan Shen, Tingting Li, Zheying Tao, Chenyang Fu, Zhongzheng Tang, Jie Yang, Li Zhang, Aifang Nie, Yiran Jiang, Jiqiu Wang, Yang Li, Yanyun Gu, Guang Ning
Rationale: NPC1 is a protein localized on the lysosome membrane regulating intracellular cholesterol transportation and maintaining normal lysosome function. GWAS studies have found that NPC1 variants in T2D was a pancreatic islet expression quantitative trait locus, suggesting a potential role of NPC1 in T2D islet pathophysiology. Methods: Two-week-old Npc1 -/- mice and wild type littermates were employed to examine pancreatic β cell morphology and functional changes induced by loss of Npc1 . Single cell RNA sequencing was conducted on primary islets...
2024: Theranostics
https://read.qxmd.com/read/38503846/endogenous-bax-and-bak-form-mosaic-rings-of-variable-size-and-composition-on-apoptotic-mitochondria
#15
JOURNAL ARTICLE
Sarah V Schweighofer, Daniel C Jans, Jan Keller-Findeisen, Anne Folmeg, Peter Ilgen, Mark Bates, Stefan Jakobs
One hallmark of apoptosis is the oligomerization of BAX and BAK to form a pore in the mitochondrial outer membrane, which mediates the release of pro-apoptotic intermembrane space proteins into the cytosol. Cells overexpressing BAX or BAK fusion proteins are a powerful model system to study the dynamics and localization of these proteins in cells. However, it is unclear whether overexpressed BAX and BAK form the same ultrastructural assemblies following the same spatiotemporal hierarchy as endogenously expressed proteins...
March 19, 2024: Cell Death and Differentiation
https://read.qxmd.com/read/38503234/simple-ammonium-salt-and-sigma-1-receptor-ligand-dipentylammonium-provides-neuroprotective-effects-in-cell-culture-and-caenorhabditis-elegans-models-of-alzheimer-s-disease
#16
JOURNAL ARTICLE
Mani Iyer Prasanth, Kanika Verma, Sirikalaya Brimson, Tewin Tencomnao, James Michael Brimson
The sigma-1 receptor (σ-1R), a chaperone protein located at the mitochondria-associated membrane (MAM) of the endoplasmic reticulum, can interact with and modify the signaling pathways of various proteins, thereby modulating many disease pathologies, including Alzheimer's disease (AD). The σ-1R ligand dipentylammonium (DPA) was analyzed for its anti-AD properties using PC12 cells (in vitro) and Caenorhabditis elegans (in vivo) models along with molecular docking (in silico) analysis. DPA at 1 and 10 µM concentrations was able to significantly potentiate NGF-induced neurite growth length by 137...
March 18, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38499486/fus-reads-histone-h3k36me3-to-regulate-alternative-polyadenylation
#17
JOURNAL ARTICLE
Junqi Jia, Haonan Fan, Xinyi Wan, Yuan Fang, Zhuoning Li, Yin Tang, Yanjun Zhang, Jun Huang, Dong Fang
Complex organisms generate differential gene expression through the same set of DNA sequences in distinct cells. The communication between chromatin and RNA regulates cellular behavior in tissues. However, little is known about how chromatin, especially histone modifications, regulates RNA polyadenylation. In this study, we found that FUS was recruited to chromatin by H3K36me3 at gene bodies. The H3K36me3 recognition of FUS was mediated by the proline residues in the ZNF domain. After these proline residues were mutated or H3K36me3 was abolished, FUS dissociated from chromatin and bound more to RNA, resulting in an increase in polyadenylation sites far from stop codons genome-wide...
March 18, 2024: Nucleic Acids Research
https://read.qxmd.com/read/38499327/sirt4-as-a-novel-interactor-and-candidate-suppressor-of-c-raf-kinase-in-mapk-signaling
#18
JOURNAL ARTICLE
Mehrnaz Mehrabipour, Saeideh Nakhaei-Rad, Radovan Dvorsky, Alexander Lang, Patrick Verhülsdonk, Mohammad R Ahmadian, Roland P Piekorz
Cellular responses leading to development, proliferation, and differentiation depend on RAF/MEK/ERK signaling, which integrates and amplifies signals from various stimuli for downstream cellular responses. C-RAF activation has been reported in many types of tumor cell proliferation and developmental disorders, necessitating the discovery of potential C-RAF protein regulators. Here, we identify a novel and specific protein interaction between C-RAF among the RAF kinase paralogs, and SIRT4 among the mitochondrial sirtuin family members SIRT3, SIRT4, and SIRT5...
June 2024: Life Science Alliance
https://read.qxmd.com/read/38499237/yap-upregulates-ampk%C3%AE-1-to-induce-cancer-cell-senescence
#19
JOURNAL ARTICLE
Yongtong Zhan, Guihao Wu, Xuhong Fan, Ze Fu, Yue Ni, Beini Sun, Hongce Chen, Tongsheng Chen, Xiaoping Wang
Yes-associated protein (YAP)-a major effector protein of the Hippo pathway- regulates cell proliferation, differentiation, apoptosis, and senescence. Amp-activated protein kinase (AMPK) is a key sensor that monitors cellular nutrient supply and energy status. Although YAP and AMPK are considered to regulate cellular senescence, it is still unclear whether AMPK is involved in YAP-regulated cellular senescence. Here, we found that YAP promoted AMPKα1 aggregation and localization around mitochondria by co-transfecting CFP-YAP and YFP-AMPKα1 plasmids...
March 16, 2024: International Journal of Biochemistry & Cell Biology
https://read.qxmd.com/read/38497895/the-phospholipids-cardiolipin-and-phosphatidylethanolamine-differentially-regulate-mdc-biogenesis
#20
JOURNAL ARTICLE
Tianyao Xiao, Alyssa M English, Zachary N Wilson, J Alan Maschek, James E Cox, Adam L Hughes
Cells utilize multiple mechanisms to maintain mitochondrial homeostasis. We recently characterized a pathway that remodels mitochondria in response to metabolic alterations and protein overload stress. This remodeling occurs via the formation of large membranous structures from the mitochondrial outer membrane called mitochondrial-derived compartments (MDCs), which are eventually released from mitochondria and degraded. Here, we conducted a microscopy-based screen in budding yeast to identify factors that regulate MDC formation...
May 6, 2024: Journal of Cell Biology
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