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Mitochondria complex

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https://www.readbyqxmd.com/read/29656200/photoinduced-anticancer-activity-studies-of-iridium-iii-complexes-targeting-mitochondria-and-tubules
#1
Wen-Yao Zhang, Qian-Yan Yi, Yang-Jie Wang, Fan Du, Miao He, Bing Tang, Dan Wan, Yun-Jun Liu, Hong-Liang Huang
Three new iridium (III) complexes [Ir (ppy)2 (ipbc)](PF6 ) (1), [Ir (bzq)2 (ipbc)](PF6 ) (2) and [Ir (piq)2 (ipbc)](PF6 ) (3) were designed and synthesized. All the complexes were tested for anticancer activity using 3-(4,5-dimethylthiazole)-2,5-diphenyltetraazolium bromide (MTT) method. The complexes show no cytotoxic activity toward cancer BEL-7402, SGC-7901, Eca-109, A549, HeLa and HepG2 cells. However, upon irradiation with white light, the complexes display high cytotoxicity against BEL-7402 cells with an IC50 value of 5...
April 7, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29653348/increased-oxidative-stress-in-the-mitochondria-isolated-from-lymphocytes-of-bipolar-disorder-patients-during-depressive-episodes
#2
Samira S Valvassori, Daniela V Bavaresco, Gustavo Feier, Kelen Cechinel-Recco, Amanda V Steckert, Roger B Varela, Cenita Borges, Milena Carvalho-Silva, Lara M Gomes, Emílio L Streck, João Quevedo
The present study aims to investigate the oxidative stress parameters in isolated mitochondria, as well as looking at mitochondrial complex activity in patients with Bipolar Disorder (BD) during depressive or euthymic episodes. This study evaluated the levels of mitochondrial complex (I, II, II-III and IV) activity in lymphocytes from BD patients. We evaluated the following oxidative stress parameters: superoxide, thiobarbituric acid reactive species (TBARS) and carbonyl levels in submitochondrial particles of lymphocytes from bipolar patients...
April 4, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29648643/mutations-in-glycyl-trna-synthetase-impair-mitochondrial-metabolism-in-neurons
#3
Veronika Boczonadi, Kathrin Meyer, Humberto Gonczarowska-Jorge, Helen Griffin, Andreas Roos, Marina Bartsakoulia, Boglarka Bansagi, Giulia Ricci, Fanni Palinkas, René P Zahedi, Francesco Bruni, Brian Kaspar, Hanns Lochmüller, Kym M Boycott, Juliane S Müller, Rita Horvath
The nuclear-encoded glycyl-tRNA synthetase gene (GARS) is essential for protein translation in both cytoplasm and mitochondria. In contrast, different genes encode the mitochondrial and cytosolic forms of most other tRNA synthetases. Dominant GARS mutations were described in inherited neuropathies, while recessive mutations cause severe childhood-onset disorders affecting skeletal muscle and heart. The downstream events explaining tissue-specific phenotype-genotype relations remained unclear. We investigated the mitochondrial function of GARS in human cell lines and in the GarsC210R mouse model...
April 10, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29643809/examination-of-the-role-of-mitochondrial-morphology-and-function-in-the-cardioprotective-effect-of-sodium-nitrite-administered-24-h-before-ischemia-reperfusion-injury
#4
Vivien Demeter-Haludka, Mária Kovács, Alexandra Petrus, Roland Patai, Danina M Muntean, László Siklós, Ágnes Végh
Background: We have previous evidence that in anesthetized dogs the inorganic sodium nitrite protects against the severe ventricular arrhythmias, resulting from coronary artery occlusion and reperfusion, when administered 24 h before. The present study aimed to examine, whether in this effect changes in mitochondrial morphology and function would play a role. Methods: Thirty dogs were infused intravenously either with saline ( n = 15) or sodium nitrite (0.2 μmol/kg/min; n = 15) for 20 min, and 24 h later, 10 dogs from each group were subjected to a 25 min period of occlusion and then reperfusion of the left anterior descending coronary artery...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29643256/critical-role-of-flavin-and-glutathione-in-complex-i-mediated-bioenergetic-failure-in-brain-ischemia-reperfusion-injury
#5
Anja Kahl, Anna Stepanova, Csaba Konrad, Corey Anderson, Giovanni Manfredi, Ping Zhou, Costantino Iadecola, Alexander Galkin
BACKGROUND AND PURPOSE: Ischemic brain injury is characterized by 2 temporally distinct but interrelated phases: ischemia (primary energy failure) and reperfusion (secondary energy failure). Loss of cerebral blood flow leads to decreased oxygen levels and energy crisis in the ischemic area, initiating a sequence of pathophysiological events that after reoxygenation lead to ischemia/reperfusion (I/R) brain damage. Mitochondrial impairment and oxidative stress are known to be early events in I/R injury...
April 11, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29643173/-mitochondrial-atp-synthase-dimers-spontaneously-associate-due-to-a-long-range-membrane-induced-force
#6
Claudio Anselmi, Karen M Davies, José D Faraldo-Gómez
Adenosine triphosphate (ATP) synthases populate the inner membranes of mitochondria, where they produce the majority of the ATP required by the cell. From yeast to vertebrates, cryoelectron tomograms of these membranes have consistently revealed a very precise organization of these enzymes. Rather than being scattered throughout the membrane, the ATP synthases form dimers, and these dimers are organized into rows that extend for hundreds of nanometers. The rows are only observed in the membrane invaginations known as cristae, specifically along their sharply curved edges...
April 11, 2018: Journal of General Physiology
https://www.readbyqxmd.com/read/29642957/characterization-of-mitochondrion-targeted-gtpases-in-plasmodium-falciparum
#7
Kirti Gupta, Ankit Gupta, Afreen Haider, Saman Habib
Ribosome assembly is critical for translation and regulating the response to cellular events and requires a complex interplay of ribosomal RNA and proteins with assembly factors. We investigated putative participants in the biogenesis of the reduced organellar ribosomes of Plasmodium falciparum and identified homologues of two assembly GTPases - EngA and Obg that were found in mitochondria. Both are indispensable in bacteria and P. berghei EngA is among the 'essential' parasite blood stage proteins identified recently...
April 12, 2018: Parasitology
https://www.readbyqxmd.com/read/29629602/deactivation-of-mitochondrial-complex-i-after-hypoxia-ischemia-in-the-immature-brain
#8
Anna Stepanova, Csaba Konrad, Sergio Guerrero-Castillo, Giovanni Manfredi, Susan Vannucci, Susanne Arnold, Alexander Galkin
Mortality from perinatal hypoxic-ischemic (HI) brain injury reached 1.15 million worldwide in 2010 and is also a major factor for neurological disability in infants. HI directly influences the oxidative phosphorylation enzyme complexes in mitochondria, but the exact mechanism of HI-reoxygenation response in brain remains largely unresolved. After induction of HI-reoxygenation in postnatal day 10 rats, activities of mitochondrial respiratory chain enzymes were analysed and complexome profiling was performed...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29628813/metabolic-profiling-of-isolated-mitochondria-and-cytoplasm-reveals-compartment-specific-metabolic-responses
#9
Daqiang Pan, Caroline Lindau, Simon Lagies, Nils Wiedemann, Bernd Kammerer
Introduction: Subcellular compartmentalization enables eukaryotic cells to carry out different reactions at the same time, resulting in different metabolite pools in the subcellular compartments. Thus, mutations affecting the mitochondrial energy metabolism could cause different metabolic alterations in mitochondria compared to the cytoplasm. Given that the metabolite pool in the cytosol is larger than that of other subcellular compartments, metabolic profiling of total cells could miss these compartment-specific metabolic alterations...
2018: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/29627383/lpaat%C3%AE-agpat4-deficiency-impairs-maximal-force-contractility-in-soleus-and-alters-fibre-type-in-extensor-digitorum-longus-muscle
#10
Ryan M Bradley, Darin Bloemberg, Juan J Aristizabal Henao, Ashkan Hashemi, Andrew S Mitchell, Val A Fajardo, Catherine Bellissimo, Emily B Mardian, Eric Bombardier, Marie-France Paré, Katherine A Moes, Ken D Stark, A Russell Tupling, Joe Quadrilatero, Robin E Duncan
Lysophosphatidic acid acyltransferase (LPAAT) δ/acylglycerophosphate acyltransferase 4 is a mitochondrial enzyme and one of five homologues that catalyze the acyl-CoA-dependent synthesis of phosphatidic acid (PA) from lysophosphatidic acid. We studied skeletal muscle LPAATδ and found highest levels in soleus, a red oxidative fibre-type that is rich in mitochondria, and lower levels in extensor digitorum longus (EDL) (white glycolytic) and gastrocnemius (mixed fibre-type). Using Lpaatδ-deficient mice, we found no change in soleus or EDL mass, or in treadmill time-to-exhaustion compared to wildtype littermates...
April 5, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29626541/use-the-protonmotive-force-mitochondrial-uncoupling-and-reactive-oxygen-species
#11
REVIEW
Brandon J Berry, Adam J Trewin, Andrea M Amitrano, Minsoo Kim, Andrew P Wojtovich
Mitochondrial respiration results in an electrochemical proton gradient, or protonmotive force (pmf), across the mitochondrial inner membrane (IM). The pmf is a form of potential energy consisting of charge (∆ψm ) and chemical (∆pH) components, that together drive ATP production. In a process called uncoupling, proton leak into the mitochondrial matrix independent of ATP production dissipates the pmf and energy is lost as heat. Other events can directly dissipate the pmf independent of ATP production as well, such as chemical exposure or mechanisms involving regulated mitochondrial membrane electrolyte transport...
April 4, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29623826/targeting-ampk-in-diabetes-and-diabetic-complications-energy-homeostasis-autophagy-and-mitochondrial-health
#12
Y V Madhavi, Nikhil Gaikwad, Veera Ganesh Yerra, Anil Kumar Kalvala, Srinivas Nanduri, Ashutosh Kumar
Adenosine 5'-monophosphate activated protein kinase (AMPK) is a key enzymatic protein involved in linking the energy sensing to the metabolic manipulation. It is a serine/threonine kinase activated by several upstream kinases. AMPK is a heterotrimeric protein complex regulated by AMP, ADP, and ATP allosterically. AMPK is ubiquitously expressed in various tissues of the living system such as heart, kidney, liver, brain and skeletal muscles. Thus malfunctioning of AMPK is expected to harbor several human pathologies especially diseases associated with metabolic and mitochondrial dysfunction...
April 6, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29620877/a-family-of-rhodium-complexes-with-selective-toxicity-towards-mismatch-repair-deficient-cancers
#13
Kelsey M Boyle, Jacqueline K Barton
Rhodium metalloinsertors are a unique set of metal complexes that bind specifically to DNA base pair mismatches in vitro and kill mismatch repair (MMR)-deficient cells at lower concentrations than their MMR-proficient counterparts. A family of metalloinsertors containing rhodium-oxygen ligand coordination, termed "Rh-O" metalloinsertors, has been prepared and shown to have a significant increase in both overall potency and selectivity towards MMR-deficient cells regardless of structural changes in the ancillary ligands...
April 5, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29619196/dual-targeting-of-the-cancer-antioxidant-network-with-1-4-naphthoquinone-fused-gold-i-n-heterocyclic-carbene-complexes
#14
R McCall, M Miles, P Lascuna, B Burney, Z Patel, K J Sidoran, V Sittaramane, J Kocerha, D A Grossie, J L Sessler, K Arumugam, J F Arambula
To achieve a systems-based approach to targeting the antioxidant pathway, 1,4-naphthoquinone annulated N-heterocyclic carbene (NHC) [bis(1,3-dimesityl-4,5-naphthoquino-imidazol-2-ylidene)-gold(i)] [silver(i) dichloride] ( 1 ), [bis(1,3-dimesityl-4,5-naphthoquino-imidazol-2-ylidene)-gold(i)] chloride ( 2 ), and 1,3-dimesityl-4,5-naphthoquino-imidazol-2-ylidene)-gold(i) chloride ( 3 )) were designed, synthesized, and tested for biological activity in a series of human cancer cell lines. The solution phase of complexes 1-3 were assigned using several spectroscopy techniques, including NMR spectroscopic analysis...
September 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29618839/metformin-adapts-its-cellular-effects-to-bioenergetic-status-in-a-model-of-metabolic-dysfunction
#15
Christopher Auger, Thibacg Sivayoganathan, Abdikarim Abdullahi, Alexandra Parousis, Bo Wen Pang, Marc G Jeschke
Thermal injury induces a complex immunometabolic response, characterized by hyperglycemia, extensive inflammation and persistent hypermetabolism. It has been suggested that attenuation of the hypermetabolic response is beneficial for patient wellbeing. To that effect, metformin represents an attractive therapeutic agent, as its effects on glycemia, inflammation and bioenergetics can improve outcomes in burn patients. Therefore, we studied metformin and its effects on mitochondrial bioenergetics in a murine model of thermal injury...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29618609/molecular-structural-diversity-of-mitochondrial-cardiolipins
#16
Gregor Oemer, Katharina Lackner, Katharina Muigg, Gerhard Krumschnabel, Katrin Watschinger, Sabrina Sailer, Herbert Lindner, Erich Gnaiger, Saskia B Wortmann, Ernst R Werner, Johannes Zschocke, Markus A Keller
Current strategies used to quantitatively describe the biological diversity of lipids by mass spectrometry are often limited in assessing the exact structural variability of individual molecular species in detail. A major challenge is represented by the extensive isobaric overlap present among lipids, hampering their accurate identification. This is especially true for cardiolipins, a mitochondria-specific class of phospholipids, which are functionally involved in many cellular functions, including energy metabolism, cristae structure, and apoptosis...
April 4, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29617867/weaning-disrupts-intestinal-antioxidant-status-impairs-intestinal-barrier-and-mitochondrial-function-and-triggers-mitophagy-in-piglets
#17
S T Cao, C C Wang, H Wu, Q H Zhang, L F Jiao, C H Hu
In the present study, we investigated the influence of weaning on antioxidant status, intestinal integrity, mitochondrial function, and the mitophagy level in piglets (weaned at 21 d) during the 1 wk after weaning. The redox status was measured by antioxidant enzymes activities, related genes expression, and malondialdehyde (MDA) content in jejunum. The intestinal barrier function was assessed by the Ussing chamber and expression of tight junction proteins in the jejunum. The function of intestine mitochondria was measured by mitochondrial DNA (mtDNA) content and activities of mitochondria oxidative phosphorylation complexes...
April 3, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29617673/mitochondrial-complex-i-inhibitors-expose-a-vulnerability-for-selective-killing-of-pten-null-cells
#18
Adam Naguib, Grinu Mathew, Colleen R Reczek, Kaitlin Watrud, Alexandra Ambrico, Tali Herzka, Irene Casanova Salas, Matthew F Lee, Nour El-Amine, Wu Zheng, M Emilia Di Francesco, Joseph R Marszalek, Darryl J Pappin, Navdeep S Chandel, Lloyd C Trotman
A hallmark of advanced prostate cancer (PC) is the concomitant loss of PTEN and p53 function. To selectively eliminate such cells, we screened cytotoxic compounds on Pten-/- ;Trp53-/- fibroblasts and their Pten-WT reference. Highly selective killing of Pten-null cells can be achieved by deguelin, a natural insecticide. Deguelin eliminates Pten-deficient cells through inhibition of mitochondrial complex I (CI). Five hundred-fold higher drug doses are needed to obtain the same killing of Pten-WT cells, even though deguelin blocks their electron transport chain equally well...
April 3, 2018: Cell Reports
https://www.readbyqxmd.com/read/29617003/the-effect-of-mitochondrial-complex-i-linked-respiration-by-isoflurane-is-independent-of-mitochondrial-nitric-oxide-production
#19
Fuqi Xu, Shigang Qiao, Hua Li, Yanjun Deng, Chen Wang, Jianzhong An
BACKGROUND: Anesthetic preconditioning (APC) of the myocardium is mediated in part by reversible alteration of mitochondrial function. Nitric oxide (NO) inhibits mitochondrial respiration and may mediate APC-induced cardioprotection. In this study, the effects of isoflurane on different states of mitochondrial respiration during the oxidation of complex I-linked substrates and the role of NO were investigated. METHODS: Mitochondria were isolated from Sprague-Dawley rat hearts...
February 1, 2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29616350/mitochondrial-dysfunction-in-parkinson-s-disease-new-mechanistic-insights-and-therapeutic-perspectives
#20
REVIEW
Jin-Sung Park, Ryan L Davis, Carolyn M Sue
PURPOSE OF REVIEW: Parkinson's disease (PD) is a complex neurodegenerative disorder, the aetiology of which is still largely unknown. Overwhelming evidence indicates that mitochondrial dysfunction is a central factor in PD pathophysiology. Here we review recent developments around mitochondrial dysfunction in familial and sporadic PD, with a brief overview of emerging therapies targeting mitochondrial dysfunction. RECENT FINDINGS: Increasing evidence supports the critical role for mitochondrial dysfunction in the development of sporadic PD, while the involvement of familial PD-related genes in the regulation of mitochondrial biology has been expanded by the discovery of new mitochondria-associated disease loci and the identification of their novel functions...
April 3, 2018: Current Neurology and Neuroscience Reports
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