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https://www.readbyqxmd.com/read/30582269/mitochondrial-damage-associated-molecular-patterns-released-by-lung-transplants-are-associated-with-primary-graft-dysfunction
#1
Davide Scozzi, Mohsen Ibrahim, Fuyi Liao, Xue Lin, Hsi-Min Hsiao, Ramsey Hachem, Laneshia Tague, Alberto Ricci, Hrishikesh S Kulkarni, Howard J Huang, Seiichiro Sugimoto, Alexander S Krupnick, Daniel Kreisel, Andrew E Gelman
Primary graft dysfunction (PGD) is a major limitation to short and long-term lung transplant survival. Recent work has shown mitochondrial damage associated molecular patterns (Mt-DAMPs) can promote solid organ injury but whether they contribute to PGD severity remains unclear. We quantitated circulating plasma Mt-DNA in 62 patients, prior to lung transplant and shortly after ICU arrival. Although all recipients released Mt-DNA, high levels were associated with severe PGD development. In a mouse orthotopic lung transplant model of PGD we detected airway cell-free damaged mitochondria and Mt-DNA in the peripheral circulation...
December 23, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/30562571/protective-effects-of-curcumin-against-ischemia-reperfusion-injury-in-the-liver
#2
REVIEW
Kowsar Bavarsad, Maryam Matbou Riahi, Saeideh Saadat, George Barreto, Stephen L Atkin, Amirhossein Sahebkar
Liver ischemia/reperfusion (I/R) injury is a major complication of hepatic surgery and transplantation. It is one of the leading causes of morbidity and mortality because of post-surgery hepatic dysfunction. Several studies have suggested different mechanisms are involved in the pathogenesis of I/R injury in the liver that includes oxidative stress, inflammation, mitochondria dysfunction, liver Kupffer cells (KCs) activation, vascular cell adhesion molecule overexpression, and facilitation of polymorphonuclear neutrophil injury...
December 15, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/30428625/furanoid-f-acid-f6-uniquely-induces-netosis-compared-to-c16-and-c18-fatty-acids-in-human-neutrophils
#3
Meraj A Khan, Cecil Pace-Asciak, Jassim M Al-Hassan, Mohammad Afzal, Yuan Fang Liu, Sosamma Oommen, Bincy M Paul, Divya Nair, Nades Palaniyar
Various biomolecules induce neutrophil extracellular trap (NET) formation or NETosis. However, the effect of fatty acids on NETosis has not been clearly established. In this study, we focused on the NETosis-inducing ability of several lipid molecules. We extracted the lipid molecules present in Arabian Gulf catfish ( Arius bilineatus , Val) skin gel, which has multiple therapeutic activities. Gas chromatography⁻mass spectrometry (GC-MS) analysis of the lipid fraction-3 from the gel with NETosis-inducing activity contained fatty acids including a furanoid F-acid (F6; 12,15-epoxy-13,14-dimethyleicosa-12,14-dienoic acid) and common long-chain fatty acids such as palmitic acid (PA; C16:0), palmitoleic acid (PO; C16:1), stearic acid (SA; C18:0), and oleic acid (OA; C18:1)...
November 13, 2018: Biomolecules
https://www.readbyqxmd.com/read/30391192/mitochondrial-transplantation-prolongs-cold-ischemia-time-in-murine-heart-transplantation
#4
Kamila Moskowitzova, Borami Shin, Kaifeng Liu, Giovanna Ramirez-Barbieri, Alvise Guariento, David Blitzer, Jerusha K Thedsanamoorthy, Rouan Yao, Erin R Snay, James A H Inkster, Arzoo Orfany, David Zurakowski, Douglas B Cowan, Alan B Packard, Gary A Visner, Pedro J Del Nido, James D McCully
BACKGROUND: Cold ischemia time (CIT) causes ischemia‒reperfusion injury to the mitochondria and detrimentally effects myocardial function and tissue viability. Mitochondrial transplantation replaces damaged mitochondria and enhances myocardial function and tissue viability. Herein we investigated the efficacy of mitochondrial transplantation in enhancing graft function and viability after prolonged CIT. METHODS: Heterotopic heart transplantation was performed in C57BL/6J mice...
September 28, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/30326737/mitochondrial-pathway-of-apoptosis-and-necrosis-contribute-to-tenofovir-disoproxil-fumarate-induced-renal-damage-in-rats
#5
H Ramamoorthy, P Abraham, B Isaac, D Selvakumar
Tenofovir disoproxil fumarate (TDF) is currently the only nucleotide analogue reverse-transcriptase inhibitor that is approved by the Food and Drug administration (FDA), USA, for the treatment of human immunodeficiency virus (HIV) infection. In recent days, renal toxicity is becoming common i HIV patients treated with TDF. However, the mechanism of tenofovir nephrotoxicity is not clear. We hypothesized that mitochondrial pathway of apoptosis, poly [ADP-ribose] polymerase (PARP) overactivation and neutrophil infiltration may contribute to tenofovir-induced renal damage...
October 16, 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/30319621/the-mitochondrion-lysosome-axis-in-adaptive-and-innate-immunity-effect-of-lupus-regulator-peptide-p140-on-mitochondria-autophagy-and-netosis
#6
Mykolas Bendorius, Indira Neeli, Fengjuan Wang, Srinivasa Reddy Bonam, Eszter Dombi, Nelly Buron, Annie Borgne-Sanchez, Joanna Poulton, Marko Radic, Sylviane Muller
Mitochondria deserve special attention as sensors of cellular energy homeostasis and metabolic state. Moreover, mitochondria integrate intra- and extra-cellular signals to determine appropriate cellular responses that range from proliferation to cell death. In autoimmunity, as in other inflammatory chronic disorders, the metabolism of immune cells may be extensively remodeled, perturbing sensitive tolerogenic mechanisms. Here, we examine the distribution and effects of the therapeutic 21-mer peptide called P140, which shows remarkable efficacy in modulating immune responses in inflammatory settings...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30312762/propofol-inhibits-endogenous-formyl-peptide-induced-neutrophil-activation-and-alleviates-lung-injury
#7
Chun-Yu Chen, Yung-Fong Tsai, Wei-Ju Huang, Shih-Hsin Chang, Tsong-Long Hwang
Critically ill patients have a high risk of sepsis. Various studies have demonstrated that propofol has anti-inflammatory effects that may benefit critically ill patients who require anesthesia. However, the mechanism and therapeutic effect remain incompletely understood. Our previous data suggest that propofol can act as a formyl peptide receptor 1 (FPR1) antagonist. Here, we hypothesize that propofol mitigates sepsis-induced acute lung injury (ALI) by inhibiting mitochondria-derived N-formyl peptide-mediated neutrophil activation...
October 10, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/30308298/atrazine-exposure-triggers-common-carp-neutrophil-apoptosis-via-the-cyp450s-ros-pathway
#8
Shengchen Wang, Qiaojian Zhang, Shufang Zheng, Menghao Chen, Fuqing Zhao, Shiwen Xu
Due to the excessive pursuit of crop yields and the abuse of herbicides, water pollution caused by atrazine (ATR) has become one of the most severe environmental issues threatening the health of fish and aquatic animals. However, no detailed report has been conducted on the mechanisms of ATR immunotoxicity in fish neutrophils. To investigate these mechanism, we exposed peripheral blood neutrophils to 25 μg/ml atrazine for 1, 2, and 3 h. The results showed that ATR induced the mRNA expression of CYPs enzymes (CYP1A1, CYP1B1, CYP1C and CYP3A138), which increased the ROS levels, and inhibited the SOD and CAT activities, GSH content and spurred the accumulation of MDA...
October 9, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/30226809/extracellular-vesicles-derived-from-human-umbilical-cord-mesenchymal-stem-cells-alleviate-rat-hepatic-ischemia-reperfusion-injury-by-suppressing-oxidative-stress-and-neutrophil-inflammatory-response
#9
Jia Yao, Jun Zheng, Jianye Cai, Kaining Zeng, Chaorong Zhou, Jiebin Zhang, Shihui Li, Hui Li, Liang Chen, Liying He, Huaxin Chen, Hongyuan Fu, Qi Zhang, Guihua Chen, Yang Yang, Yingcai Zhang
Mesenchymal stem cells (MSCs) have been reported to exert therapeutic effects on immunoregulation, tissue repair, and regeneration from the bench to the bedside. Increasing evidence demonstrates that extracellular vesicles (EVs) derived from MSCs could contribute to these effects and are considered as a potential replacement for stem cell-based therapies. However, the efficacy and underlying mechanisms of EV-based treatment in hepatic ischemia-reperfusion injury (IRI) remain unclear. Here, we demonstrated that human umbilical cord MSC-EVs (huc-MSC-EVs) could protect against IRI-induced hepatic apoptosis by reducing the infiltration of neutrophils and alleviating oxidative stress in hepatic tissue in vivo...
September 18, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30095413/surface-modification-affect-the-biodistribution-and-toxicity-characteristics-of-iron-oxide-magnetic-nanoparticles-in-rats
#10
Pengfei Yang, Hengyi Xu, Zhihong Zhang, Lin Yang, Huijuan Kuang, Zoraida P Aguilar
Various surface modifications of iron oxide magnetic nanoparticles (IOMNs) can improve their stability and long-term retention time in vivo , expanding applications of biomedical fields. However, whether the long-term retention of IOMNs coated with different surface modifications has toxic effects remains poorly understood. Here, the toxicity of IOMNs modified with polyethylene glycol (PEG), bovine serum albumin (BSA), and carboxyl group (COOH), forming PEG-IOMNs, BSA-IOMNs, and COOH-IOMNs, respectively, were evaluated in the rats...
August 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/30089724/circulating-mitochondria-in-deceased-organ-donors-are-associated-with-immune-activation-and-early-allograft-dysfunction
#11
Justin Pollara, R Whitney Edwards, Liwen Lin, Victoria A Bendersky, Todd V Brennan
Brain death that occurs in the setting of deceased organ donation for transplantation is associated with systemic inflammation of unknown origin. It has recently been recognized that mitochondria-derived damage-associated molecular patterns (mtDAMPs) released into the circulation in the setting of trauma and tissue injury are associated with a systemic inflammatory response. We examined the blood of deceased organ donors and found elevated levels of inflammatory cytokines and chemokines that correlated with levels of mtDAMPs...
August 9, 2018: JCI Insight
https://www.readbyqxmd.com/read/29787548/a-subset-of-five-human-mitochondrial-formyl-peptides-mimics-bacterial-peptides-and-functionally-deactivates-human-neutrophils
#12
Elzbieta Kaczmarek, Carl J Hauser, Woon Yong Kwon, Ingred Riça, Li Chen, Nicola Sandler, Leo E Otterbein, Yan Campbell, Charles H Cook, Michael B Yaffe, Michael F Marusich, Kiyoshi Itagaki
BACKGROUND: Trauma causes inflammation by releasing mitochondria that act as Danger-Associated Molecular Patterns (DAMPs). Trauma also increases susceptibility to infection. Human mitochondria contain 13 N-formyl peptides (mtFPs). We studied whether mtFPs released into plasma by clinical injury induce neutrophil (PMN) inflammatory responses, whether their potency reflects their similarity to bacterial FPs and how their presence at clinically relevant concentration affects PMN function...
November 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29753511/acute-adrenal-cortex-injury-during-cardiopulmonary-bypass-in-a-canine-model
#13
Bo Mei, Song Yang, Yuan Yue, Jian Hou, Keke Wang, Guangxian Chen, Mengya Liang, Zhongkai Wu
OBJECTIVE: Cardiopulmonary bypass (CPB) might induce systemic inflammatory responses that cause acute injuries to multiple organs. However, no direct evidence exists to determine whether CPB leads to adrenal cortex injury or to describe its underlying mechanism. METHODS: Twelve healthy adult beagles were randomly assigned into control and CPB groups. After cannulation, mild hypothermia CPB was performed in the CPB group but not in the control group. The serum concentrations of various cytokines, cortisol, and aldosterone were assessed...
August 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29722336/mitochondrial-autophagy-and-nlrp3-inflammasome-in-pulmonary-tissues-from-severe-combined-immunodeficient-mice-after-cardiac-arrest-and-cardiopulmonary-resuscitation
#14
Jing-Jun Lyu, Jawahar L Mehta, Yi Li, Lu Ye, Sheng-Nan Sun, Hong-Shuang Sun, Jia-Chang Li, Dong-Mei Zhang, Jie Wei
Background: The incidence of cancer, diabetes, and autoimmune diseases has been increasing. Furthermore, there are more and more patients with solid organ transplants. The survival rate of these immunocompromised individuals is extremely low when they are severely hit-on. In this study, we established cardiac arrest cardiopulmonary resuscitation (CPR) model in severe combined immunodeficient (SCID) mice, analyzed the expression and activation of mitochondrial autophagy and NLRP3 inflammasome/caspase-1, and explored mitochondrial repair and inflammatory injury in immunodeficiency individual during systemic ischemia-reperfusion injury...
May 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29682165/urinary-mitochondrial-dna-identifies-renal-dysfunction-and-mitochondrial-damage-in-sepsis-induced-acute-kidney-injury
#15
Qiongyuan Hu, Jianan Ren, Huajian Ren, Jie Wu, Xiuwen Wu, Song Liu, Gefei Wang, Guosheng Gu, Kun Guo, Jieshou Li
Background: Recent animal studies have shown that mitochondrial dysfunction initiates and accelerates renal injury in sepsis, but its role in sepsis remains unknown. Mitochondrial stress or dying cells can lead to fragmentation of the mitochondrial genome, which is considered a surrogate marker of mitochondrial dysfunction. Therefore, we evaluated the efficiency of urinary mitochondrial DNA (UmtDNA) as a marker of renal dysfunction during sepsis-induced acute kidney injury (AKI). Methods: We isolated DNA from plasma and urine of patients...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29658397/inflammation-coagulation-response-and-thrombotic-effects-induced-by-silica-nanoparticles-in-zebrafish-embryos
#16
Junchao Duan, Shuang Liang, Yang Yu, Yang Li, Lijing Wang, Zehao Wu, Yueyue Chen, Mark R Miller, Zhiwei Sun
Nowadays, nanotechnology environmental health and safety (nanoEHS) is gaining attention. We previously found that silica nanoparticles (SiNPs) could induce vascular endothelial damage. However, the subsequent toxicologic response to SiNPs-induced endothelial damage was still largely unknown. In this study, we explored the inflammation-coagulation response and thrombotic effects of SiNPs in endothelial cells and zebrafish embryos. For in vitro study, swollen mitochondria and autophagosome were observed in ultrastructural analysis...
June 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29590639/neutrophil-specific-knockout-demonstrates-a-role-for-mitochondria-in-regulating-neutrophil-motility-in-zebrafish
#17
Wenqing Zhou, Lingyan Cao, Jacob Jeffries, Xiaoguang Zhu, Christopher J Staiger, Qing Deng
Neutrophils are fast-moving cells essential for host immune functions. Although they primarily rely on glycolysis for ATP, isolated primary human neutrophils depend on mitochondrial membrane potential for chemotaxis. However, it is not known whether mitochondria regulate neutrophil motility in vivo , and the underlying molecular mechanisms remain obscure. Here, we visualized mitochondria in an interconnected network that localizes to the front and rear of migrating neutrophils using a novel transgenic zebrafish line...
March 28, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29486699/mitochondria-targeted-antioxidant-skq1-10-6%C3%A2-plastoquinonyl-decyltriphenylphosphonium-bromide-inhibits-mast-cell-degranulation-in-vivo-and-in-vitro
#18
M A Chelombitko, O A Averina, T V Vasilyeva, O Yu Pletiushkina, E N Popova, A V Fedorov, B V Chernyak, V S Shishkina, O P Ilinskaya
The therapeutic effect of mitochondria-targeted antioxidant 10-(6´-plastoquinonyl)decyltriphenylphosphonium bromide (SkQ1) in experimental models of acute inflammation and wound repair has been shown earlier. It was suggested that the antiinflammatory activity of SkQ1 is related to its ability to suppress inflammatory activation of the vascular endothelium and neutrophil migration into tissues. Here, we demonstrated that SkQ1 inhibits activation of mast cells (MCs) followed by their degranulation and histamine release in vivo and in vitro...
December 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/29478824/an-unexpected-player-in-gaucher-disease-the-multiple-roles-of-complement-in-disease-development
#19
REVIEW
Manoj K Pandey, Gregory A Grabowski, Jörg Köhl
The complement system is well appreciated for its role as an important effector of innate immunity that is activated by the classical, lectin or alternative pathway. C5a is one important mediator of the system that is generated in response to canonical and non-canonical C5 cleavage by circulating or cell-derived proteases. In addition to its function as a chemoattractant for neutrophils and other myeloid effectors, C5a and its sister molecule C3a have concerted roles in cell homeostasis and surveillance. Through activation of their cognate G protein coupled receptors, C3a and C5a regulate multiple intracellular pathways within the mitochondria and the lysosomal compartments that harbor multiple enzymes critical for protein, carbohydrate and lipid metabolism...
June 2018: Seminars in Immunology
https://www.readbyqxmd.com/read/29467458/maresin-1-attenuates-mitochondrial-dysfunction-through-the-alx-camp-ros-pathway-in-the-cecal-ligation-and-puncture-mouse-model-and-sepsis-patients
#20
Jiaqi Gu, Lingchun Luo, Qian Wang, Songfan Yan, Jing Lin, Dan Li, Bingbing Cao, Hongxia Mei, Binyu Ying, Lu Bin, Fang Gao Smith, Sheng-Wei Jin
Inflammation always accompanies infection during sepsis. Mitochondrial dysfunction and the role of reactive oxygen species (ROS) produced by mitochondria have been proposed in the pathogenesis of sepsis. Maresins have protective and resolving effects in experimental models of infection. In the present study, we investigated the effects of maresin 1 (MaR1) on mitochondrial function in cecal ligation and puncture (CLP)-induced sepsis and sepsis patients to identify mechanisms underlying maresin 1-mediated stimulation of ROS in mitochondria...
June 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
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