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https://www.readbyqxmd.com/read/28649877/retrospective-cohort-study-and-biobanking-of-patients-treated-for-hemangioma-in-childhood-telomeres-as-biomarker-of-aging-and-radiation-exposure
#1
Monika Frenzel, Michelle Ricoul, Mohamed Amine Benadjaoud, Marion Bellamy, Aude Lenain, Nadia Haddy, Ibrahima Diallo, Christine Mateus, Florent de Vathaire, Laure Sabatier
PURPOSE: Cohorts allowing joint epidemiological and biological analyses are essential for radiation risk assessment. The French Hemangioma Cohort (FHC), studied within the European project EpiRadBio, is one of the rare cohorts suitable for studying the effect of low dose radiation exposure (<100 mGy at organs), with a long-term follow-up. This highly homogeneous cohort consists of healthy individuals belonging to a normal population, except for the presence of skin hemangioma (age at exposure: between 6 months and 3 years of age)...
June 26, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28648371/impacts-of-tannery-effluent-on-development-and-morphological-characters-in-a-neotropical-tadpole
#2
Mateus Flores Montalvão, André Luis da Silva Castro, Aline Sueli de Lima Rodrigues, Bruna de Oliveira Mendes, Guilherme Malafaia
Previous studies have shown the contamination of rivers and streams caused by tannery effluents (TE). However, the effects of TE on amphibians are still unknown. Thus, we evaluated whether the TE, even at low concentrations (0.2%), could cause asymmetric development (inferred through the fluctuating asymmetry indices (FA)) and changes in morphological characteristics of Physalaemus cuvieri larvae. Accordingly, the tadpoles were distributed in groups non-exposed (n=160) and exposed (n=160) to this TE, for 15days...
June 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28646772/prevalence-of-immune-related-systemic-adverse-events-in%C3%A2-patients-treated-with-anti-programmed-cell-death-1-anti-programmed-cell-death-ligand-1-agents-a-single-centre-pharmacovigilance-database-analysis
#3
Sébastien Le Burel, Stéphane Champiat, Christine Mateus, Aurélien Marabelle, Jean-Marie Michot, Caroline Robert, Rakiba Belkhir, Jean-Charles Soria, Salim Laghouati, Anne-Laure Voisin, Olivier Fain, Arsène Mékinian, Laetitia Coutte, Tali-Anne Szwebel, Laetitia Dunogeant, Bertrand Lioger, Cécile Luxembourger, Xavier Mariette, Olivier Lambotte
AIM: The growing use of immune checkpoint inhibitors (ICIs) is associated with the occurrence of immune-related adverse events (irAEs). Few data are published on systemic, immunohaematological and rheumatic irAEs. In a pharmacovigilance database analysis, we screened for these irAEs and calculated their prevalence. PATIENTS AND METHODS: Participants were recruited via Registre des Effets Indésirables Sévères des Anticorps Monoclonaux Immunomodulateurs en Cancérologie (REISAMIC)(1) a French registry of grade ≥2 irAEs occurring in ICI-treated patients...
June 21, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28640478/usefulness-of-office-examination-with-narrow-band-imaging-for-the-diagnosis-of-head-and-neck-squamous-cell-carcinoma-and-follow-up-of-premalignant-lesions
#4
Isabel Vilaseca, Meritxell Valls-Mateus, Anna Nogués, Eduardo Lehrer, Mauricio López-Chacón, Francesc Xavier Avilés-Jurado, José Luis Blanch, Manuel Bernal-Sprekelsen
BACKGROUND: The purpose of this study was to evaluate the value of narrow band imaging (NBI) examination in the office for the diagnosis and follow-up of upper airway premalignant and malignant lesions. METHODS: Four hundred eighty lesions were evaluated with white light endoscopy (WLE) and NBI before a biopsy/excision. Additionally, 151 premalignant lesions were followed up without proven biopsy. Carcinoma-free survival was calculated. The learning curve was analyzed...
June 22, 2017: Head & Neck
https://www.readbyqxmd.com/read/28639723/changes-in-the-inspiratory-pattern-contribute-to-modulate-the-sympathetic-activity-in-sino-aortic-denervated-rats
#5
Mateus R Amorim, Leni G H Bonagamba, George M P R Souza, Davi J A Moraes, Benedito H Machado
The activity of pre-sympathetic neurons is under respiratory modulation and changes in the central respiratory network may impact on the baseline sympathetic activity and mean arterial pressure (MAP). It is well known that after baroreceptor afferents removal (sino-aortic denervation, SAD), rats present an unexpected normal levels of MAP. We hypothesized that changes in the respiratory pattern and in the respiratory modulation of the sympathetic activity contribute to keep the sympathetic outflow in a normal range of variation in absence of arterial baroreceptors in rats...
June 22, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28627932/short-term-prognostic-effect-of-prior-cerebrovascular-and-peripheral-artery-disease-in-patients-with-acute-coronary-syndrome-can-we-do-better
#6
Filipa Cordeiro, Pedro S Mateus, Alberto Ferreira, Silvia Leao, Miguel Moz, J Ilidio Moreira
BACKGROUND: We sought to evaluate the impact of prior cerebrovascular and/or peripheral arterial disease (PAD) on in-hospital outcomes in patients with acute coronary syndromes. METHODS: From 1 October 2010 to 26 February 2016, 13,904 acute coronary syndrome patients were enrolled in a national multicentre registry. They were divided into four groups: prior stroke/transient ischaemic attack (stroke/TIA); prior PAD; prior stroke/TIA and PAD; none. The endpoints included in-hospital mortality and a composite endpoint of death, re-infarction and stroke during hospitalization...
June 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28624490/bioenergetics-dysfunction-mitochondrial-permeability-transition-pore-opening-and-lipid-peroxidation-induced-by-hydrogen-sulfide-as-relevant-pathomechanisms-underlying-the-neurological-dysfunction-characteristic-of-ethylmalonic-encephalopathy
#7
Gabriela Miranda Fernandez Cardoso, Julia Tauana Pletsch, Belisa Parmeggiani, Mateus Grings, Nícolas Manzke Glanzel, Larissa Daniele Bobermin, Alexandre Umpierrez Amaral, Moacir Wajner, Guilhian Leipnitz
Hydrogen sulfide (sulfide) accumulates at high levels in the brains of patients with ethylmalonic encephalopathy (EE). In the present study, we evaluated whether sulfide could disturb energy and redox homeostasis, and induce mitochondrial permeability transition (mPT) pore opening in rat brain aiming to better clarify the neuropathophysiology of EE. Sulfide decreased the activities of citrate synthase and aconitase in rat cerebral cortex mitochondria, and of creatine kinase (CK) in rat cerebral cortex, striatum and hippocampus supernatants...
June 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28621940/on-the-solvation-and-proton-coupled-electron-transfer-reduction-potential-of-2-no-%C3%A2-to-1-hno-in-aqueous-solution-a-theoretical-investigation
#8
Mateus F Venancio, Fabio Doctorovich, Willian Ricardo Rocha
In this work quantum mechanical calculations and Monte Carlo statistical mechanical simulations were carried out to investigate the solvation properties of HNO in aqueous solution and to evaluate the proton coupled one electron reduction potential of 2NO to 1HNO, which are essential missing information to understand the fate of 2NO in the biological medium. Our results showed that the 1HNO molecule acts mainly as hydrogen bond donor in aqueous solution with an average energy of -5.5  1.3 kcal/mol. The solvation free energy of 1HNO in aqueous solution, computed using three approaches based on the Liner Response Theory revealed that the current prediction of the hydration free energy of HNO is, at least, two times underestimated...
June 16, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28611474/p38%C3%AE-regulates-cytokine-induced-ifn%C3%AE-secretion-via-the-mnk1-eif4e-pathway-in-th1-cells
#9
María Salvador-Bernáldez, Sara B Mateus, Iván Del Barco Barrantes, Simon C Arthur, Carlos Martínez-A, Angel R Nebreda, Jesús M Salvador
The p38 mitogen-activated protein kinase (MAPK) pathway is involved in the regulation of immune and inflammatory processes. We used p38α-conditional, p38β-deficient, and p38α/β double-null mouse models to address the role of these two p38 MAPK in CD4(+) T cells, and found that p38α deficiency causes these cells to hyperproliferate. Our studies indicate that both p38α and p38β are dispensable for T helper cell type 1 (Th1) differentiation but, by controlling IFNγ and TNFα production, are critical for normal Th1 effector function...
June 14, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28610826/structural-ultrastructural-and-immunohistochemical-evidence-of-testosterone-effects-and-its-ablation-on-the-bulbourethal-gland-of-the-artibeus-planirostris-bat-chiroptera-mammalia
#10
Cíntia C I Puga, Mateus R Beguelini, Eliana Morielle-Versute, Patricia S L Vilamaior, Sebastião R Taboga
This study evaluated the effects of testosterone in the bulbourethral glands (BG) of the bat, Artibeus planirostris, by performing castration and posterior hormonal supplementation of the animals. The results showed a decrease in testosterone levels in animals 15days after castration, which induced a small reduction in epithelium height, percentage of AR+ cells, and an increase in the amount of basal cells. This reduction became more severe in groups castrated for longer periods (19 and 22days), where there was also an increase in apoptotic cells...
June 10, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28610263/taxonomic-and-distributional-notes-on-spongilla-flies-neuroptera-sisyridae-from-southeastern-brazil-with-first-interactive-key-to-the-species-of-the-country
#11
Alice Carvalho Assmar, Frederico Falcão Salles
Based on adults collected from Espírito Santo, Southeastern Brazil, we present the first reports of Sisyridae from the state, expanding the known distributional range of five species of Climacia McLachlan and Sisyra Burmeister. Adults were collected throughout two basins, Rio Doce and São Mateus, and its tributaries in the north of the state with Pennsylvania light trap. Two species are reported for the first time from Southeastern Brazil. Furthermore, we describe the male of Climacia basalis Banks and compare it with the male of its junior synonym, C...
June 1, 2017: Zootaxa
https://www.readbyqxmd.com/read/28607784/use-of-nonvascularized-autologous-fibular-strut-graft-in-the-treatment-of-major-bone-defect-after-periprosthetic-knee-fracture
#12
Vincenzo Giordano, Bruno Parilha Coutinho, Mateus Kenji Miyahira, Felipe Serrão Mendes de Souza, Ney Pecegueiro do Amaral
We present the case of a patient who suffered a comminuted supracondylar periprosthetic femur fracture. The patient was an 86-year-old lady who suffered a minor fall at home and presented at our hospital with a right comminuted distal femur fracture around a total knee arthroplasty. The patient was submitted to a cruciate-sacrificing total knee replacement 6 years before at the same institution. Despite severe metaphyseal fragmentation and short distal fragment, the prosthesis was stable; thus, open fracture reduction and stabilization with internal fixation were performed...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28605196/%C3%AE-ag2-2xznxwo4-0-%C3%A2-x-%C3%A2-0-25-solid-solutions-structure-morphology-and-optical-properties
#13
Paula F S Pereira, Clayane C Santos, Amanda F Gouveia, Mateus M Ferrer, Ivo M Pinatti, Gleice Botelho, Julio R Sambrano, Ieda L V Rosa, Juan Andrés, Elson Longo
A theoretical study was elaborated to support the experimental results of the Zn-doped α-Ag2WO4. Theses α-Ag2-2xZnxWO4 (0 ≤ x ≤ 0.25) solid solutions were obtained by coprecipitation method. X-ray diffraction data indicated that all α-Ag2-2xZnxWO4 (0 ≤ x ≤ 0.25) microcrystals presented an orthorhombic structure. The experimental values of the micro-Raman frequencies were in reasonable agreement with both previously reported and calculated results. Microscopy images showed that the replacement of Ag(+) by Zn(2+) promoted a reduction in the average crystal size and modifications in the morphology, from rod-like with hexagonal shape to roll-like with a curved surface...
June 12, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28604797/a-human-inferred-germline-antibody-binds-to-an-immunodominant-epitope-and-neutralizes-zika-virus
#14
Diogo M Magnani, Cassia G T Silveira, Brandon C Rosen, Michael J Ricciardi, Núria Pedreño-Lopez, Martin J Gutman, Varian K Bailey, Helen S Maxwell, Aline Domingues, Lucas Gonzalez-Nieto, Vivian I Avelino-Silva, Mateus Trindade, Juliana Nogueira, Consuelo S Oliveira, Alvino Maestri, Alvina Clara Felix, José Eduardo Levi, Mauricio L Nogueira, Mauricio A Martins, José M Martinez-Navio, Sebastian P Fuchs, Stephen S Whitehead, Dennis R Burton, Ronald C Desrosiers, Esper G Kallas, David I Watkins
The isolation of neutralizing monoclonal antibodies (nmAbs) against the Zika virus (ZIKV) might lead to novel preventative strategies for infections in at-risk individuals, primarily pregnant women. Here we describe the characterization of human mAbs from the plasmablasts of an acutely infected patient. One of the 18 mAbs had the unusual feature of binding to and neutralizing ZIKV despite not appearing to have been diversified by affinity maturation. This mAb neutralized ZIKV (Neut50 ~ 2 μg/ml) but did not react with any of the four dengue virus serotypes...
June 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28601998/side-effects-of-spirotetramat-on-pupae-and-adults-of-a-neotropical-strain-of-eretmocerus-mundus-hymenoptera-aphelinidae-effects-on-the-life-parameters-and-demography
#15
Natalia Francesena, Nicolas Desneux, Mateus Ribeiro de Campos, Marcela Inés Schneider
The negative impact of conventional pesticides on the environment is already extensively discussed worldwide. Although the use of chemical agents for controlling agricultural pests remains as first-line strategy for pest control, novel biorational active insecticides, such as spirotetramat, have appeared in the pesticide market during recent years in Argentina. The aim of this study was to assess the toxicity of spirotetramat on two developmental stages of a Neotropical strain of Eretmocerus mundus, with the conventional insecticide cypermethrin as a positive control, and to determine spirotetramat's side effects on parasitoid demographic parameters...
June 10, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28595324/bacteriophage-use-to-control-salmonella-biofilm-on-surfaces-present-in-chicken-slaughterhouses
#16
Keila Carolina de Ornellas Dutka Garcia, Isadora Mainieri de Oliveira Corrêa, Larissa Quinto Pereira, Tarcísio Macedo Silva, Mateus de Souza Ribeiro Mioni, Ana Carolina de Moraes Izidoro, Igor Henrique Vellano Bastos, Guilherme Augusto Marietto Gonçalves, Adriano Sakai Okamoto, Raphael Lucio Andreatti Filho
Foodborne diseases represent a major risk to public health worldwide. Pathogenic bacteria can live in the form of biofilm within the food industry, providing a permanent source of contamination. The aim of this study was to evaluate the influence of the types of adhesion surfaces on Salmonella biofilm formation at eight different times, and analyze the action time of a bacteriophage pool on established biofilms. Most of the samples used were classified as weak biofilm producers, with serovars Enteritidis and Heidelberg showing the highest frequency of biofilm formation...
June 8, 2017: Poultry Science
https://www.readbyqxmd.com/read/28589723/molecular-interaction-between-salivary-proteins-and-food-tannins
#17
Mafalda Silva, Ignacio García-Estévez, Elsa Brandão, Nuno Mateus, Victor De Freitas, Susana Soares
Polyphenols interaction with salivary proteins (SP) has been related with organoleptic features such as astringency. The aim of this work was to study the interaction between some human SP and tannins through two spectroscopic techniques, fluorescence quenching and Saturation Transfer Difference-Nuclear Magnetic Resonance (STD-NMR). Generally, the results showed a significant interaction between SP and both condensed tannins and ellagitannins. Herein, STD-NMR proved to be a useful tool to map tannins' epitopes of binding, while fluorescence quenching allowed to discriminate binding affinities...
June 7, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28585931/the-modulation-of-adult-neuroplasticity-is-involved-in-the-mood-improving-actions-of-atypical-antipsychotics-in-an-animal-model-of-depression
#18
M Morais, P Patrício, A Mateus-Pinheiro, N D Alves, A R Machado-Santos, J S Correia, J Pereira, L Pinto, N Sousa, J M Bessa
Depression is a prevalent psychiatric disorder with an increasing impact in global public health. However, a large proportion of patients treated with currently available antidepressant drugs fail to achieve remission. Recently, antipsychotic drugs have received approval for the treatment of antidepressant-resistant forms of major depression. The modulation of adult neuroplasticity, namely hippocampal neurogenesis and neuronal remodeling, has been considered to have a key role in the therapeutic effects of antidepressants...
June 6, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28583268/voice-disorders-in-residual-paracoccidioidomycosis-in-upper-airways-and-digestive-tract
#19
Ananda Dutra da Costa, Amanda Pereira Vargas, Marcia Mendonça Lucena, Ana Cristina Nunes Ruas, Fernanda da Silva Santos Braga, Mateus Pereira Bom-Braga, Frederico Pereira Bom-Braga, Antonio Carlos Francesconi do Valle, Ricardo Pereira Igreja, Cláudia Maria Valete-Rosalino
BACKGROUND: Paracoccidioidomycosis (PCM) is a systemic mycosis of acute and chronic evolution, caused by species belonging to the genus Paracoccidioides. It is considered the most prevalent systemic endemic mycosis in Latin America, with cases in the tropical and subtropical regions. Residual PCM refers to the fibrotic scar sequelae resulting from the disease treatment which, when associated with collagen accumulation, leads to functional and anatomic alterations in the organs. AIMS: The aim of this study was to evaluate the vocal function of patients with residual PCM in upper airways and digestive tract...
June 2, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28576938/neuro-immune-glia-interactions-in-the-sensory-ganglia-account-for-the-development-of-acute-herpetic-neuralgia
#20
Jaqueline R Silva, Alexandre H Lopes, Jhimmy Talbot, Nerry T Cecilio, Mateus F Rossato, Rangel L Silva, Guilherme R Souza, Cassia R Silva, Guilherme Lucas, Benedito A Fonseca, Eurico Arruda, Jose C Alves-Filho, Fernando Q Cunha, Thiago M Cunha
Herpetic neuralgia is the most important symptom of herpes zoster disease, which is caused by Varicella zoster. Nevertheless, the pathophysiological mechanisms involved in herpetic neuralgia are not totally elucidated. Here, we examined the neuro-immune interactions at the sensory ganglia that account for the genesis of herpetic neuralgia by using a murine model of Herpes simplex virus type-1 (HSV-1) infection. The cutaneous HSV-1 infection of mice results in the development of a zosteriform-like skin lesion followed by a time-dependent increase in pain-like responses (mechanical allodynia)...
June 2, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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