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Mariana Bisarro Dos Reis, Mateus Camargo Barros-Filho, Fábio Albuquerque Marchi, Caroline Moraes Beltrami, Hellen Kuasne, Clóvis Antônio Lopes Pinto, Srikant Ambatipudi, Zdenko Herceg, Luiz Paulo Kowalski, Silvia Regina Rogatto
Context: Even though the majority of well-differentiated thyroid cancer (WDTC) is indolent, a number of cases display an aggressive behavior. Cumulative evidences have suggested that the deregulation of DNA methylation has the potential to point out molecular markers associated with worse prognosis. Objective: To identify a prognostic epigenetic signature in thyroid cancer. Design: Genome-wide DNA methylation assays (450k platform, Illumina) were performed in a cohort of 50 non-neoplastic thyroid tissues (NT), 17 benign thyroid lesions (BTL) and 74 thyroid carcinomas (60 papillary, 8 follicular, 2 Hürthle cell, 1 poorly differentiated and 3 anaplastic)...
August 16, 2017: Journal of Clinical Endocrinology and Metabolism
Dalmarcia de Sousa Carlos Mourão, Talita Ferreira de Souza Pereira, Danival José de Souza, Aloísio Freitas Chagas Júnior, Mateus Sunti Dalcin, Ronice Alves Veloso, Evelynne Urzêdo Leão, Gil Rodrigues Dos Santos
The Curvularia Leaf Spot is becoming more common due to the culture expansion and the low resistance of the cultivated genotypes in tropical regions. Thus, the objective was to evaluate the fungitoxicity of the essential oil of Cymbopogon citratus upon the phytopathogen Curvularia lunata, causative agent of the Curvularia Leaf Spot. There was realized pathogenicity tests of C. lunata in maize plants, phytotoxicity of the essential oil of C. citratus and gas chromatography attached, germination tests of the conidia, and of in vitro inhibition of C...
August 20, 2017: Medicines (Basel, Switzerland)
Janaina Costa E Silva, Dalmarcia de Sousa Carlos Mourão, Fabia Silva de Oliveira Lima, Renato de Almeida Sarmento, Mateus Sunti Dalcin, Raimundo Wagner de Souza Aguiar, Gil Rodrigues Dos Santos
The objective of this work was to evaluate the efficiency of noni essential oil on the control of Exserohilum turcicum, a causative agent of Exserohilum spot in maize culture. In the sanitary test 400 seeds were incubated using the blotter test method. For the transmissibility test, the fragments of damaged leaves of seedlings were removed and put into a potato, dextrose and agar (PDA) culture environment. To verify the pathogenicity, Koch´s postulates were performed. In the phytotoxicity test different concentrations of noni oil were applied in maize seedlings...
August 14, 2017: Medicines (Basel, Switzerland)
Sebastian A Suarez, Martina Muñoz, Lucia Alvarez, Mateus F Venancio, Willian Rocha, Damian E Bikiel, Marcelo A Marti, Fabio Doctorovich
Azanone (nitroxyl, HNO) is a highly reactive compound whose biological role is still a matter of debate. One possible route for its formation is NO reduction by biological reductants. These reactions have been historically discarded due to the negative redox potential for the NO,H+/HNO couple. However, the NO to HNO conversion mediated by vitamins C, E and aromatic alcohols has been recently shown to be feasible from a chemical standpoint. Based on these precedents we decided to study the reaction of NO with thiols as potential sources of HNO...
September 19, 2017: Journal of the American Chemical Society
Rafael Del Caño, Lucia Mateus, Guadalupe Sánchez-Obrero, José Manuel Sevilla, Rafael Madueño, Manuel Blázquez, Teresa Pineda
In this work, we report on the electrochemical behavior of bioconjugates prepared with gold nanoparticles (AuNP) capped with three different molecular layers (citrate anions, 6-mercaptopurine and ω-mercaptoundecanoic acid) and the protein hemoglobin (Hb). Freshly formed bioconjugates are deposited on a glassy carbon electrode and assayed for electroactivity. A pair of redox peaks with formal potential at -0.37V is obtained, in contrast with the free Hb protein that is inactive on the glassy carbon substrate...
January 1, 2018: Talanta
Marilesia Ferreira de Souza, Hellen Kuasne, Mateus de Camargo Barros-Filho, Heloísa Lizotti Cilião, Fabio Albuquerque Marchi, Paulo Emilio Fuganti, Alexandre Rossi Paschoal, Silvia Regina Rogatto, Ilce Mara de Syllos Cólus
Circulating nucleic acids are found in free form in body fluids and may serve as minimally invasive tools for cancer diagnosis and prognosis. Only a few studies have investigated the potential application of circulating mRNAs and microRNAs (miRNAs) in prostate cancer (PCa). The Cancer Genome Atlas (TCGA) database was used for an in silico analysis to identify circulating mRNA and miRNA as potential markers of PCa. A total of 2,267 genes and 49 miRNAs were differentially expressed between normal and tumor samples...
2017: PloS One
Mateus L Stivanin, Marcelo Duarte, Camila Sartori, Naylil M R Capreti, Celio F F Angolini, Igor D Jurberg
A novel, scalable strategy for the preparation of 2,3,4,6-tetrasubstituted pyridines is described. This protocol has two steps: an aminocatalyzed addition of ketones to alkylidene isoxazol-5-ones, followed by an iron-mediated decarboxylative cyclization event. Mechanistic insights for both steps are provided based on HRMS-ESI(+) studies.
September 14, 2017: Journal of Organic Chemistry
António Lima Grilo, Marilia Mateus, M Raquel Aires-Barros, Ana M Azevedo
Monoclonal antibodies currently dominate the biopharmaceutical market with growing sales having reached 80 billion USD in 2016. As most top-selling mAbs are approaching the end of their patent life, biopharmaceutical companies compete fiercely in the biosimilars market. These two factors present a strong motivation for alternative process strategies and process optimization. In this work a novel purification strategy for monoclonal antibodies comprising phenylboronic acid multimodal chromatography for capture followed by polishing by ion exchange monolithic chromatography and packed bed hydrophobic interaction chromatography is presented and compared to the traditional protein-A-based process...
September 13, 2017: Biotechnology Journal
Mateus Flores Montalvão, Guilherme Malafaia
Abamectin is one of the most used pesticides worldwide. However, investigations about its effects on amphibian populations are rare. Thus, the present study sought to investigate possible cytotoxic effects on Lithobates catesbeianus tadpoles exposed to low abamectin concentrations diluted in water. Accordingly, four experimental groups were set: negative control, positive control (cyclophosphamide-40 mL L(-1)), abamectin at concentrations 36 μg a.i./L (ABA36 group), and 72 μg a.i./L (ABA72 group), applied as Kraft® 36EC...
September 11, 2017: Environmental Science and Pollution Research International
George Miguel P R Souza, Mateus R Amorim, Davi J A Moraes, Benedito H Machado
Obstructive sleep apnea (OSA) is a complex disease in which humans face episodes of intermittent hypoxia and it affects men and women. Patients with OSA present hypertension and sympathetic overactivity among several other dysfunctions. Therefore, one important question remains: are the autonomic dysfunctions associated with OSA similar in male and female? This is an unresolved question since sex factors are overlooked in most clinical and experimental studies. Epidemiological data indicate that sex exerts an important influence in the prevalence of OSA and associated comorbidities, such as hypertension...
September 8, 2017: Respiratory Physiology & Neurobiology
Bruna Piaia Ramborger, Claudia Alves Ortis Gularte, Daniela Teixeira Rodrigues, Mateus Cristofari Gayer, Murilo Ricardo Sigal Carriço, Matheus Chimelo Bianchini, Robson Luiz Puntel, Elton Luis Gasparotto Denardin, Rafael Roehrs
The possible phytoremediation capacity of Plectranthus neochilus (boldo) exposed to the commercial pesticide (Aminol) in soil and water through consecutive extractions (days interval) was evaluated. After the exposure period, tea leaves from the plant were analyzed in terms of the presence of 2,4-D, total antioxidant capacity (DPPH), concentration of total polyphenols and flavonoids for plants exposed to soil and water. In water, 2,4-D remained up to 67% in the 60 days of experiment in the control group, which provided the use of two treatment groups with the plant (one group of plants for 30 days and another group in the remaining 30 days in the same system), thus, a decontamination up to 49% of the 2,4-D was obtained in this system with water...
August 31, 2017: Chemosphere
Nicholas Joseph Tavares da Cruz, Álvaro Guillermo Rojas Lezana, Paulo da Cruz Freire Dos Santos, Ibsen Mateus Bittencourt Santana Pinto, Claudio Zancan, Gustavo Henrique Silva de Souza
Cemeteries and crematoria are the main funeral ways used in the world nowadays. It is a little-studied segment in the present days, mainly as for the possible environmental impacts in the environment, such as those derived from dental amalgam, prostheses, and dioxins, among other. This article aimed to identify the environmental impacts caused by cemeteries and crematoria and to point out new trends in funeral processes such as freeze-drying and alkaline hydrolysis. The study is justified due to the large part of the Brazilian population that do not know the environmental impacts caused by cemeteries and crematoria, as well as to bring information about the new processes...
September 7, 2017: Environmental Science and Pollution Research International
Marcelo Fialho de Moura, Mayara Cristina Lopes, Renata Ramos Pereira, Jorgiane Benevenute Parish, Mateus Chediak, Lucas de Paulo Arcanjo, Daiane das Graças do Carmo, Marcelo Coutinho Picanço
BACKGROUND: Empoasca kraemeri is an important pest of the common bean in the tropics and subtropics. However, economic injury levels and sequential sampling plans for this pest have not yet been determined for this crop. Thus, the objectives of this research were to determine E. kraemeri sequential sampling plans and economic injury levels in the common bean at different crop technological levels. RESULTS: Common bean plants tolerate low attack intensities of this pest (up to 1 adult...
September 6, 2017: Pest Management Science
Jefferson J Soares, Mayara B Gonçalves, Mateus C Gayer, Matheus C Bianchini, Aline C Caurio, Susana J Soares, Robson L Puntel, Rafael Roehrs, Elton L G Denardin
Fly fruit Drosophila melanogaster (DM) has been extensively employed as an in vivo model system to study pesticides toxicity. Pesticide administration to the fly traditionally involves feeding in an agar-gelled feed fly's medium (AM). However, AM method has several limitations such as uncertainty regarding the bioavailability and amount of pesticides ingested. And also high manipulation of the treated flies. We developed a new method of exposure the flies to pesticides, called Continuous Liquid Feeding (CLF)...
September 1, 2017: Analytical Biochemistry
Sabin Llona-Minguez, Andreas Höglund, Artin Ghassemian, Matthieu Desroses, José Manuel Calderón-Montaño, Estefanía Burgos Morón, Nicholas C K Valerie, Elisee Wiita, Ingrid Almlöf, Tobias Koolmeister, André Mateus, Cindy Cazares-Körner, Kumar Sanjiv, Evert Homan, Olga Loseva, Pawel Baranczewski, Masoud Darabi, Amir Mehdizadeh, Shabnam Fayezi, Ann-Sofie Jemth, Ulrika Warpman Berglund, Kristmundur Sigmundsson, Thomas Lundbäck, Annika Jenmalm Jensen, Per Artursson, Martin Scobie, Thomas Helleday
No abstract text is available yet for this article.
September 1, 2017: Journal of Medicinal Chemistry
Joana Azevedo, Ana Fernandes, Joana Oliveira, Natércia Fernandes Brás, Sofia Reis, Paulo Lopes, Isabel Roseira, Miguel Cabral, Nuno Mateus, Victor De Freitas
The aim of this study was to evaluate the reactivity of phenolic compounds extracted from cork stoppers to wine model solutions with two major wine components, namely (+)-catechin and malvidin-3-O-glucoside. Besides the formation of some compounds already described in the literature, these reactions also yielded a new family of ellagitannin-derived compounds, named herein as corklins. This new family of compounds that were found to result from the interaction between ellagitannins in alcoholic solutions and (+)-catechin were structurally characterized by mass spectroscopy, NMR and computational methods...
September 1, 2017: Journal of Agricultural and Food Chemistry
Nuno D Alves, Patrícia Patrício, Joana S Correia, António Mateus-Pinheiro, Ana R Machado-Santos, Eduardo Loureiro-Campos, Mónica Morais, João M Bessa, Nuno Sousa, Luísa Pinto
The continuous generation of new neurons and glial cells in the adult hippocampal dentate gyrus (DG) represents an important form of adult neuroplasticity, involved in normal brain function and behavior but also associated with the etiopathogenesis and treatment of psychiatric disorders. Despite the large number of studies addressing cell genesis along the septotemporal axis, data on the anatomical gradients of cytogenesis along the DG transverse axis is scarce, especially after exposure to stress. As such, in this study we characterized both basal proliferation and survival of adult-born neural cells along the transverse axis of the rat dorsal DG, and after stress exposure...
August 29, 2017: Brain Structure & Function
Jefferson J Soares, Daniela T Rodrigues, Mayara B Gonçalves, Maurício C Lemos, Mariana S Gallarreta, Matheus C Bianchini, Mateus C Gayer, Robson L Puntel, Rafael Roehrs, Elton L G Denardin
Extracts from the leaves of Bougainvillea glabra Choisy are used in traditional medicines, but their actions on the central nervous system have not been studied. In the present study, we investigated the potential neuroprotective effects of Bougainvillea glabra Choisy leaf extract (BG extract) against paraquat (PQ)-induced neurotoxicity. Male adult wild-type flies (1- 4days old) were exposed to PQ (3.5mM) and/or BG extract (120μg/mL) through food for 4days. PQ-fed flies had decreased locomotor capacity in negative geotaxis and crossing number assays and had a higher incidence of mortality than the control group...
August 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Mateus Ribeiro da Silva, Carla Andreia Freixo Portela, Silvia Maria Ferreira Albani, Paola Rizzo de Paiva, Martha Massako Tanizaki, Teresa Cristina Zangirolami
Haemophilus influenzae type b (Hib), a Gram-negative capsulated bacterium, is a causative agent of meningitis worldwide. The capsular polysaccharide, a high molecular mass polymer consisting of the repeated units of the polyribosyl-ribitol-phosphate, is considered the main virulence factor and it is used as an antigen to vaccines, conjugated to a carrier protein. The industrial production of the polysaccharide requires the cultivation of Hib in rich medium, which impacts process costs and product recovery. In this study, a central composite rotational experimental design strategy was used to access the influence of key components of culture medium (soy peptone, yeast extract and glucose) on biomass formation and polysaccharide production in shake-flasks...
August 25, 2017: Biotechnology Progress
Heraldo Mendes Garmes, José Barreto Campello Carvalheira, Fabiano Reis, Luciano de Souza Queiroz, Mateus Dal Fabbro, Vanessa de Fatima Porto Souza, Allan de Oliviera Santos
BACKGROUND: Pituitary carcinoma is extremely rare and carries a very poor prognosis. In most cases, apparently indolent tumors become malignant; however, there are no satisfactory biomarkers for predicting tumor behavior. Thus, scientific advances in the search for new biological markers, diagnostic methods, and therapies are needed to improve the prognosis of these patients. CASE DESCRIPTION: We report the case of a woman with initial diagnosis of nonfunctioning pituitary adenoma which evolved to carcinoma after 4 years...
2017: Surgical Neurology International
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