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https://www.readbyqxmd.com/read/29331748/safety-and-efficacy-of-anti-programmed-death-1-antibodies-in-patients-with-cancer-and-pre-existing-autoimmune-or-inflammatory-disease
#1
François-Xavier Danlos, Anne-Laure Voisin, Valérie Dyevre, Jean-Marie Michot, Emilie Routier, Laurent Taillade, Stéphane Champiat, Sandrine Aspeslagh, Julien Haroche, Laurence Albiges, Christophe Massard, Nicolas Girard, Stéphane Dalle, Benjamin Besse, Salim Laghouati, Jean-Charles Soria, Christine Mateus, Caroline Robert, Emilie Lanoy, Aurélien Marabelle, Olivier Lambotte
OBJECTIVE: Patients with autoimmune or inflammatory disease (AID) are susceptible to immune-related adverse events (irAEs) when treated with immune check-point inhibitors (ICIs). We decided to analyse the safety and effectiveness of anti-PD-1 antibodies in AID patients and look for an association between the presence of pre-existing AID and the clinical outcome. METHODS: In a prospective study of the REISAMIC registry of grade ≥2 irAEs occurring in ICI-treated patients, we studied the associations between pre-existing AID on one hand and irAE-free survival, overall survival and best objective response rate on the other...
January 10, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29326905/neuromuscular-features-in-sprinters-with-cerebral-palsy-case-studies-based-on-paralympic-classification
#2
Diego Antunes, Mateus Rossato, Rafael Lima Kons, Raphael Luiz Sakugawa, Gabriela Fischer
Despite the evolution of runner performance in athletes with cerebral palsy (CP), little is known about neuromuscular parameters of sprinters from different classes, especially related to power output, muscular imbalances and asymmetry indexes in lower limbs. The aim of this study was to assess muscle power, muscular imbalance and asymmetry in sprinters with CP. Four male sprinters with CP (age, 18 to 27 years; body mass, 58.5 to 72.8 kg; height, 161.5 to 174 cm) classified as T38, T37, T36, T35 according to International Paralympic Committee functional classification, performed vertical counter movement jump and squat jump on force plate and isokinetic torque evaluations in both limbs...
December 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29322271/responses-of-macroinvertebrate-communities-to-pesticide-application-in-irrigated-rice-fields
#3
Cristina Stenert, Íris C M F de Mello, Mateus M Pires, Débora S Knauth, Naoki Katayama, Leonardo Maltchik
The ability to recover to original states after disturbances makes macroinvertebrates useful tools for assessing the impacts of pesticides. Many studies showed that direct exposure to pesticides decreases macroinvertebrate richness and alters their composition. The main objective of this study was to assess recovery patterns in macroinvertebrate communities after pesticide application in irrigated rice fields. We analyzed short-term temporal dynamics of macroinvertebrate communities after application of the herbicides bispyribac-sodium and clomazone and the insecticide chlorantraniliprole, over the rice-growing season in southern Brazil...
January 10, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29319777/encapsulating-peritoneal-sclerosis-case-report
#4
Gabriel Caetano Pereira, Igor Fiorese Vieira, Mateus Mazorra Coelho Vieira, Eliezer Moreno Romano, Luiz Eduardo Bersani Amado
Patients with chronic kidney disease (CDK) can develop several diseases caused by the renal replacement therapy. Here we report a rare complication of peritoneal dialysis, the encapsulating peritoneal sclerosis (EPS) in which the peritoneal tissue is gradually replaced by fibrous tissue. The patient in question, after late loss of renal graft and conversion to peritoneal dialysis, evolved with multiple hospitalizations for spontaneous bacterial infections, in recent admission, he was diagnosed with sub-occlusive abdomen secondary to the EPS...
October 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29303860/mandibular-osteonecrosis-associated-with-raloxifene
#5
Hélder Antônio Rebelo Pontes, Lucas Lacerda de Souza, Daniel Cavalléro Colares Uchôa, João Mateus Mendes Cerqueira
Osteonecrosis is a disease with diverse pathophysiology, clinical presentation, and management. It may be associated with some medications used to treat systemic issues with bone metabolism. A few cases of jaw bone osteonecrosis have been associated with raloxifene. In this paper, the authors present a clinical report of a 64-year-old woman who presented with a necrosis foci in the right alveolar ridge of the mandible, associated with continued raloxifene use.
January 4, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29291385/serological-detection-and-molecular-characterization-of-piroplasmids-in-equids-in-brazil
#6
Maria Isabel Botelho Vieira, Márcio Machado Costa, Mateus Tonial de Oliveira, Luiz Ricardo Gonçalves, Marcos Rogério André, Rosangela Zacarias Machado
Equine piroplasmosis is a disease caused by the hemoparasites Babesia caballi and Theileria equi and is considered to be the most important parasitic infection affecting Equidae. The objective of the present study was to carry out an epidemiological molecular and serological survey for the presence of these two protozoal organisms in equids from the northwestern region of the State of Rio Grande do Sul (RS), south Brazil. For this purpose, blood samples were collected from 90 equids in the city of Passo Fundo, RS, Brazil...
December 29, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29287391/blackberry-anthocyanins-%C3%AE-cyclodextrin-fortification-for-thermal-and-gastrointestinal-stabilization
#7
Ana Fernandes, Marisa A A Rocha, Luis M N B F Santos, Joana Brás, Joana Oliveira, Nuno Mateus, Victor de Freitas
Anthocyanins are potential food colorants due to their color, low toxicity and biological properties. However, the low chemical stability of anthocyanins has limited their use. In this work, the thermal stability of cyanidin-3-O-glucoside (cy3glc) (major blackberry anthocyanin) and blackberry purees through molecular inclusion with β-cyclodextrin (β-CD) was assessed. Complexation with β-CD showed a thermal stabilization of cy3glc, resulting on a decrease of the degradation rate constant (k) and in several alterations in the cy3glc-β-CD DSC thermogram...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29286652/semisynthetic-phenol-derivatives-obtained-from-natural-phenols-antimicrobial-activity-and-molecular-properties
#8
Patrícia Fontes Pinheiro, Luciana Alves Parreira Menini, Patrícia Campos Bernardes, Sérgio Henriques Saraiva, José Walkimar Mesquita Carneiro, Adilson Vidal Costa, Társila Rodrigues Arruda, Mateus Ribeiro Lage, Patrícia Martins Gonçalves, Carolina de Oliveira Bernardes, Elson Santiago Alvarenga, Luciano Menini
Semisynthetic phenol derivatives were obtained from the natural phenols: thymol, carvacrol, eugenol, and guaiacol through catalytic oxychlorination, Williamson synthesis, and aromatic Claisen rearrangement. The compounds characterization was carried out by 1H NMR, 13C NMR, and mass spectrometry. The natural phenols and their semisynthetic derivatives were tested for their antimicrobial activity against the bacteria: Staphylococcus aureus, Escherichia coli, Listeria innocua, Pseudomonas aeruginosa, Salmonella enterica Typhimurium, Salmonella enterica ssp...
December 29, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29282135/implementation-of-a-relatives-toolkit-impart-study-an-iterative-case-study-to-identify-key-factors-impacting-on-the-implementation-of-a-web-based-supported-self-management-intervention-for-relatives-of-people-with-psychosis-or-bipolar-experiences-in-a-national
#9
Fiona Lobban, Victoria Appleton, Duncan Appelbe, Johanna Barraclough, Julie Bowland, Naomi R Fisher, Sheena Foster, Sonia Johnson, Elizabeth Lewis, Céu Mateus, Barbara Mezes, Elizabeth Murray, Puffin O'Hanlon, Vanessa Pinfold, Jo Rycroft-Malone, Ron Siddle, Jo Smith, Chris J Sutton, Andrew Walker, Steven H Jones
BACKGROUND: Web-based interventions to support people to manage long-term health conditions are available and effective but rarely used in clinical services. The aim of this study is to identify critical factors impacting on the implementation of an online supported self-management intervention for relatives of people with recent onset psychosis or bipolar disorder into routine clinical care and to use this information to inform an implementation plan to facilitate widespread use and inform wider implementation of digital health interventions...
December 28, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/29280659/prevalence-of-hypovitaminosis-d-and-associated-factors-in-adolescent-students-of-a-capital-of-northeastern-brazil
#10
Euarda Pontes Dos Santos Araújo, Dayanna Joyce Marques Queiroz, Juliana Padilha Ramos Neves, Lavoisiana Mateus de Lacerda, Maria Da Conceição Rodrigues Gonçalves, Alice Teles de Carvalho
BACKGROUND: Hypovitaminosis D is a frequent problem in the world and can be influenced by several factors. OBJECTIVE: To estimate the prevalence of hypovitaminosis D and associated factors in adolescent students of a capital city of northeastern Brazil. METHODS: Cross-sectional epidemiological study assessing 220 school adolescents of both sexes aged 15 to 19 years. A questionnaire was applied to assess sociodemographic (skin color, mother's education and receiving social benefits) and behavioral data (number of hours of sleep per day, sun exposure, physical activity and dietary vitamin D intake)...
November 16, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29278967/physiotherapy-methods-to-facilitate-pelvic-floor-muscle-contraction-a-systematic-review
#11
Elaine Cristine Lemes Mateus-Vasconcelos Pt PhD, Aline Moreira Ribeiro Pt MSc, Flávia Ignácio Antônio Pt PhD, Luiz Gustavo de Oliveira Brito PhD, Cristine Homsi Jorge Ferreira
AIM: To undertake a systematic review of the literature on physical therapy methods to facilitate voluntary pelvic floor muscles (PFM) contraction. METHODS: The databases consulted were PubMed, the Cochrane Central Register of Controlled Trials, the Cochrane Database of Systematic Reviews, PEDro and CINHAL. The study included randomized controlled trials, quasi-experimental trials and systematic reviews. The GRADE scale was used to assess methodological quality...
December 26, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29277697/characterization-and-gene-expression-analysis-of-pacu-piaractus-mesopotamicus-inducible-nitric-oxide-synthase-inos-following-aeromonas-dhakensis-infection
#12
Mateus M Carriero, Flávio Henrique-Silva, Alexandre Rodrigues Caetano, Francisco Pereira Lobo, Anderson Luis Alves, Eduardo Sousa Varela, Maite Del Collado, Gabriel S A Moreira, Antonio A M Maia
Nitric oxide (NO) is an important effector molecule which is involved in a myriad of biological processes, including immune responses against pathogens such as parasites, virus and bacteria. During the inflammatory processes in vertebrates, NO is produced by the inducible nitric oxide synthase (iNOS) enzyme in practically all nucleated cells to suppress or kill intracellular pathogens. The aim of the present study was to characterize the full coding region of the iNOS gene of pacu (Piaractus mesopotamicus), an economically and ecologically important South American fish species, and to analyze mRNA expression levels following intraperitoneal infection with the pathogenic bacterium Aeromonas dhakensis by means of quantitative real time PCR (qPCR)...
December 22, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29277453/sarcoidosis-post-anti-pd-1-therapy-mimicking-relapse-of-metastatic-melanoma-in-a-patient-undergoing-complete-remission
#13
N Yatim, C Mateus, P Charles
Novel treatments of metastatic melanoma include the usage of checkpoint inhibitors such as anti-cytotoxic-T-lymphocyte-associated antigen (CTLA-4) or anti-programmed death-1 (PD-1) antibodies, which are immunomodulatory antibodies that enhance the immune response against tumors. While they have substantially improved the prognosis for patients, these therapies are associated with a large spectrum of immune-related adverse effects (irAEs). We report a patient developing pulmonary and cutaneous sarcoidosis after pembrolizumab therapy while complete regression of stage IV melanoma was perceived...
December 22, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29275130/evaluation-of-antibacterial-and-modifying-action-of-catechin-antibiotics-in-resistant-strains
#14
Fernanda Mateus Silva Gomes, Jayze da Cunha Xavier, Joycy Francely Sampaio Dos Santos, Yedda Maria Lobo Soares de Matos, Saulo Relison Tintino, Thiago Sampaio de Freitas, Henrique Douglas Melo Coutinho
Diseases caused by bacteria are today one of the great problems of present time. Access to over-the-counter medication, the indiscriminate use of antibacterials and high rates of hospitalization have contributed to the increase in cases. This picture has led to the search for new alternative drugs. Thus, secondary metabolites have been reported as a possible treatment option, being evidenced in many researches to ascertain their combination with existing drugs. This research aimed to evaluate the antibacterial effect and the antibiotic activity modifying action of the catechin compound against Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus multiresistant strains...
December 21, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29273783/clay-content-and-ph-soil-characteristic-associations-with-the-persistent-presence-of-chronic-wasting-disease-in-northern-illinois
#15
Sheena J Dorak, Michelle L Green, Michelle M Wander, Marilyn O Ruiz, Michael G Buhnerkempe, Ting Tian, Jan E Novakofski, Nohra E Mateus-Pinilla
Environmental reservoirs are important to infectious disease transmission and persistence, but empirical analyses are relatively few. The natural environment is a reservoir for prions that cause chronic wasting disease (CWD) and influences the risk of transmission to susceptible cervids. Soil is one environmental component demonstrated to affect prion infectivity and persistence. Here we provide the first landscape predictive model for CWD based solely on soil characteristics. We built a boosted regression tree model to predict the probability of the persistent presence of CWD in a region of northern Illinois using CWD surveillance in deer and soils data...
December 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29261700/effect-of-feeding-rumen-protected-methionine-on-productive-and-reproductive-performance-of-dairy-cows
#16
Mateus Z Toledo, Giovanni M Baez, Alvaro Garcia-Guerra, Nelson E Lobos, Jerry N Guenther, Eduardo Trevisol, Daniel Luchini, Randy D Shaver, Milo C Wiltbank
The objectives of this study were to evaluate the effects of daily top-dressing (individually feeding on the top of the total mixed ration) with rumen-protected methionine (RPM) from 30 ± 3 until 126 ± 3 Days in milk on productive and reproductive performance in lactating dairy cows. A total of 309 lactating dairy Holstein cows (138 primiparous and 171 multiparous) were randomly assigned to treatment diets containing either RPM (21.2 g of RPM + 38.8 g of dried distillers grain; 2.34% Methionine [Met] of metabolizable protein [MP]) or Control (CON; 60 g of dried distillers grain; 1...
2017: PloS One
https://www.readbyqxmd.com/read/29260013/popular-stroke-knowledge-in-brazil-a-multicenter-survey-during-world-stroke-day
#17
Ana Beatriz Ayroza Galvão Ribeiro Gomes, Mauro Henrique, Vinicius Andreoli Schoeps, Mariana Monteiro Saldanha Altenfelder Santos, Ada Pellegrinelli, Bárbara Pessoa de Matos, Gabriel Taricani Kubota, Haniel Alves Araújo, Letícia Sant' Ana Cardoso da Silva, Fabrício de Paula Leite Battisti, Bruno Yukio Kubota, Areta Cavalcanti Ferreira, Mateus Paquesse Pellegrino, Renata de Andrade Prado, Ronaldo Abrahm, Vivian Dias Baptista Gagliardi, Marcel Simis, Rubens José Gagliardi
Context and objective: Cerebrovascular disease is one of the most important causes of death and disability worldwide. The patient's inability to identify the warning signs of stroke substantially delays the search for emergency services, which is related directly to a worse outcome. Thus, during the 2011 Stroke Campaign in Brazil, a survey was conducted to identify the lay population's knowledge with regard to the recognition, treatment, and prevention of stroke. Design and setting: This retrospective, cross-sectional, multicenter study was held in cities throughout southeastern Brazil...
March 2017: ENeurologicalSci
https://www.readbyqxmd.com/read/29245708/new-species-of-i-poecilocloeus-i-bruner-1910-orthoptera-acrididae-proctolabinae-from-paran%C3%A3-state-brazil
#18
Maria Kátia Matiotti DA Costa, Marcos Fianco, Fernando DE Farias Martins, Victor Mateus Prasniewski, Neucir Szinwelski, Edison Zefa
In this study, we describe a new species of the genus Poecilocloeus from Renascença municipality, Paraná State, Brazil. Poecilocloeus renascensis n. sp. inhabits the Atlantic Semideciduous Forest edges of Renascença and adjacent areas, and our study is the first record of this genus from southern Brazil. The species belongs to the group bullatus (Rehn, 1908), and the descriptions are based on morphological characters, mainly from male genitalia. Morphological descriptions are provided together with illustrations emphasizing the most significant diagnostic features of external morphology and male genitalia...
October 30, 2017: Zootaxa
https://www.readbyqxmd.com/read/29241126/the-chronic-exposure-to-abamectin-causes-spatial-memory-deficit-and-depressive-behavior-in-mice
#19
Wellington Alves Mizael da Silva, Abraão Tiago Batista Guimarães, Mateus Flores Montalvão, Bruna de Oliveira Mendes, Aline Sueli de Lima Rodrigues, Guilherme Malafaia
It is known that abamectin (ABA), which is a component belonging to the group of avermectins, has been broadly used as biopesticide. Although its effect on non-target aquatic organisms is known, knowledge about its impacts on terrestrial animals such as mammals remains incipient. Thus, we aim at investigating the effects (phycical and neural-behavioral) from the chronic exposure (90 days) to ABA (1/10 of LD50) on Swiss and C57Bl/6J mice from both sexes. Accordingly, at the end of the experimental period the animals were subjected to the following tests: Novel Object Recognition Test (NORT), Morris Water Maze (MWM), Tail Suspension Test (TST), and Forced Swimming Test (FST)...
December 7, 2017: Chemosphere
https://www.readbyqxmd.com/read/29236918/peri-implant-assessment-via-cone-beam-computed-tomography-and-digital-periapical-radiography-an-ex-vivo-study
#20
Nicolau Silveira-Neto, Mateus Ericson Flores, João Paulo De Carli, Max Dória Costa, Felipe de Souza Matos, Luiz Renato Paranhos, Maria Salete Sandini Linden
OBJECTIVES: This research evaluated detail registration in peri-implant bone using two different cone beam computer tomography systems and a digital periapical radiograph. METHODS: Three different image acquisition protocols were established for each cone beam computer tomography apparatus, and three clinical situations were simulated in an ex vivo fresh pig mandible: buccal bone defect, peri-implant bone defect, and bone contact. Data were subjected to two analyses: quantitative and qualitative...
November 2017: Clinics
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