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https://www.readbyqxmd.com/read/28521279/chronic-stress-impairs-the-local-immune-response-during-cutaneous-repair-in-gilthead-sea-bream-sparus-aurata-l
#1
Ana Patrícia Mateus, Liliana Anjos, João R Cardoso, Deborah M Power
Scale removal in fish triggers a damage-repair program to re-establish the lost epidermis and scale and an associated local immune response. In mammals, chronic stress is known to delay wound healing and to modulate the cutaneous stress axis, but this is unstudied in teleost fish the most successful extant vertebrates. The present study was designed to test the hypothesis that chronic stress impairs cutaneous repair in teleost fish as a consequence of suppression of the immune response. The hypothesis was tested by removing the scales and damaging the skin on one side of the body of fish previously exposed for 4 weeks to a chronic crowding stress and then evaluating cutaneous repair for 1 week...
May 15, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28516287/spread-of-poxviruses-in-livestock-in-brazil-associated-with-cases-of-double-and-triple-infection
#2
Mateus Laguardia-Nascimento, Ana Paula Ferreira de Oliveira, Isabela Ciarlini Azevedo, Anselmo Vasconcelos Rivetti Júnior, Marcelo Fernandes Camargos, Antônio Augusto Fonseca Júnior
The objective of this work is to describe the distribution of outbreaks of vaccinia virus (VACV), pseudocowpox virus (PCPV), and bovine papular stomatitis virus (BSPV) in Brazil. The Official Laboratory of the Brazilian Ministry of Agriculture received 89 samples from different locations in Brazil in 2015 and 2016 for diagnosis of vesicular and exanthematous disease. Poxvirus coinfections occurred in 11 out of 33 outbreaks, including the first reported triple infection by BPSV, PCPV, and VACV. This occurrence may be associated with the circulation of these viruses in Brazilian cattle...
May 17, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28512495/endodontic-management-of-open-apex-teeth-using-lyophilized-collagen-sponge-and-mta-cement-report-of-two-cases
#3
Miriam Graziele Magro, Milton Carlos Kuga, Weber Adad Ricci, Kátia Cristina Keine, Mateus Rodrigues Tonetto, Suellen Linares Lima, Alvaro Henrique Borges, Lauriê Garcia Belizário, Matheus Coêlho Bandeca
Teeth with open apices, such as in immature teeth or those with apical root resorption are clinical cases with difficult immediate resolution. With the use of mineral trioxide aggregate (MTA) in dentistry, it was possible to optimize the treatment time of these cases by immediate placement of apical plug and the root canal filling. However, some negative effects can occur if MTA is extruded beyond the apex. To avoid this accident, it has been recommended to use of an apical matrix prior to placement of MTA...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28508636/piperazin-1-ylpyridazine-derivatives-are-a-novel-class-of-human-dctp-pyrophosphatase-1-inhibitors
#4
Sabin Llona-Minguez, Andreas Höglund, Artin Ghassemian, Matthieu Desroses, José Manuel Calderón-Montaño, Estefanía Burgos Morón, Nicholas C K Valerie, Elisee Wiita, Ingrid Almlöf, Tobias Koolmeister, André Mateus, Cindy Cazares-Körner, Kumar Sanjiv, Evert Homan, Olga Loseva, Pawel Baranczewski, Masoud Darabi, Amir Mehdizadeh, Shabnam Fayezi, Ann-Sofie Jemth, Ulrika Warpman Berglund, Kristmundur Sigmundsson, Thomas Lundbäck, Annika Jenmalm Jensen, Per Artursson, Martin Scobie, Thomas Helleday
The dCTP pyrophosphatase 1 (dCTPase) is a nucleotide pool "housekeeping" enzyme responsible for the catabolism of canonical and noncanonical nucleoside triphosphates (dNTPs) and has been associated with cancer progression and cancer cell stemness. We have identified a series of piperazin-1-ylpyridazines as a new class of potent dCTPase inhibitors. Lead compounds increase dCTPase thermal and protease stability, display outstanding selectivity over related enzymes and synergize with a cytidine analogue against leukemic cells...
May 16, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28506641/guiding-multimodal-registration-with-learned-optimization-updates
#5
Benjamin Gutierrez-Becker, Diana Mateus, Loic Peter, Nassir Navab
In this paper, we address the multimodal registration problem from a novel perspective, aiming to predict the transformation aligning images directly from their visual appearance. We formulate the prediction as a supervised regression task, with joint image descriptors as input and the output are the parameters of the transformation that guide the moving image towards alignment. We model the joint local appearance with context aware descriptors that capture both local and global cues simultaneously in the two modalities, while the regression function is based on the gradient boosted trees method capable of handling the very large contextual feature space...
May 6, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28505282/survival-and-locomotory-behavior-of-earwigs-after-exposure-to-reduced-risk-insecticides
#6
Catarina D Freitas, Lessando M Gontijo, Raul Narciso C Guedes, Mateus Chediak
The conservation of natural enemies is an important tactic to promote biological control of arthropod pests. The earwig Doru luteipes (Sccuder) is the most important predator of the fall armyworm Spodoptera frugiperda (J.E. Smith) in corn fields. One way of conserving these predators in the field is by using only selective insecticides when the pest population reaches the economic threshold. Some recent insecticides such as azadirachtin, chlorantraniliprole, and novaluron have been claimed to pose reduced risk for natural enemies...
May 12, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28505144/microbiota-and-particulate-matter-assessment-in-portuguese-optical-shops-providing-contact-lens-services
#7
Carla Viegas, Tiago Faria, Cátia Pacífico, Mateus Dos Santos, Ana Monteiro, Carla Lança, Elisabete Carolino, Susana Viegas, Sandra Cabo Verde
The aim of this work was to assess the microbiota (fungi and bacteria) and particulate matter in optical shops, contributing to a specific protocol to ensure a proper assessment. Air samples were collected through an impaction method. Surface and equipment swab samples were also collected side-by-side. Measurements of particulate matter were performed using portable direct-reading equipment. A walkthrough survey and checklist was also applied in each shop. Regarding air sampling, eight of the 13 shops analysed were above the legal requirement and 10 from the 26 surfaces samples were overloaded...
May 15, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/28504433/influence-of-shading-and-pedestrian-traffic-on-the-preference-of-aedes-stegomyia-aegypti-diptera-culicidae-for-oviposition-microenvironments
#8
G P Prado, J S Maciel, G R Leite, M A A Souza
Aedes aegypti mosquitoes are highly adaptable to abiotic stimuli. To evaluate the influence of shading and pedestrian traffic on the preference of Ae. aegypti for oviposition microenvironments, 20 sites were sampled weekly using ovitraps within the perimeter of Universidade Federal do Espírito Santo, located in São Mateus, Espírito Santo, Brazil. A spatial and statistical analysis was performed in order to assess the relationship between shading time, pedestrian traffic, and the presence of biological forms of Ae...
June 2017: Journal of Vector Ecology: Journal of the Society for Vector Ecology
https://www.readbyqxmd.com/read/28501036/tuberculosis-in-liver-transplant-recipients-a-report-of-eight-cases-during-a-five-year-period
#9
Diana Póvoas, João Machado, Rui Perdigoto, Ana Morbey, Júlio Veloso, Helena Glória, Élia Mateus, Américo Martins, Fernando Maltez, Eduardo Barroso
INTRODUCTION: Tuberculosis incidence in Portugal ranged from 20 to 22 cases per 100 000 inhabitants between 2010 and 2014. Tuberculosis incidence in liver transplant recipients is not precisely known, but it is estimated to be higher than among the general population. Tuberculosis in liver transplant recipients is particularly challenging because of the atypical clinical presentation and side effects of the antibacillary drugs and their potential interactions with immunosuppressive therapies...
January 31, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28495087/gemcitabine-anti-proliferative-activity-significantly-enhanced-upon-conjugation-with-cell-penetrating-peptides
#10
Nuno Vale, Abigail Ferreira, Iva Fernandes, Cláudia Alves, Maria João Araújo, Nuno Mateus, Paula Gomes
Gemcitabine proven efficiency against a wide range of solid tumors and undergoes deamination to its inactive uridine metabolite, which underlies its low bioavailability, and tumour resistance was also associated with nucleoside transporter alterations. Hence, we have conjugated gemcitabine to cell-penetrating peptides (CPP), in an effort to both mask its aniline moiety and facilitate its delivery into cancer cells. Two CPP-drug conjugates have been synthesized and studied regarding both the time-dependent kinetics of gemcitabine release and their anti-proliferative activity on three different human cancer cell lines...
April 28, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28492692/pharmacokinetics-of-table-and-port-red-wine-anthocyanins-a-crossover-trial-in-healthy-men
#11
I Fernandes, C Marques, A Évora, L Cruz, V de Freitas, C Calhau, A Faria, N Mateus
This study was designed to evaluate the pharmacokinetics of Port and table red wine anthocyanins in healthy men. Volunteers were recruited to drink 250 mL of a table red wine (221 mg of anthocyanins) and 150 mL of young Port red wine (49 mg of anthocyanins). Venous blood was collected from participants at 0, 15, 30, 60 and 120 min after wine ingestion. Urine samples were collected at baseline and at 120 min. Anthocyanins and anthocyanin metabolites in plasma and urine samples were quantified by HPLC-DAD and tentatively identified by LC-MS...
May 11, 2017: Food & Function
https://www.readbyqxmd.com/read/28491174/diagnosis-of-abnormally-invasive-posterior-placentation-the-role-of-mr-imaging
#12
Madison R Kocher, Douglas H Sheafor, Evelyn Bruner, Charles Newman, Julio Fernando Mateus Nino
Abnormally invasive placentation is becoming more common with a recent increase in cesarean sections and maternal age, among other risk factors. Ultrasonography is the first line-imaging, but it can be difficult to diagnose when limiting factors are present. Failure to recognize this serious placental abnormality precludes us from making the appropriate plan for the delivery and consequently can lead to fatal results. In this report, we present a case in which magnetic resonance imaging was used to diagnose posterior placenta increta missed by multiple sonographic examinations in a patient with previous myomectomies, and we also include a review of the literature on this topic...
June 2017: Radiology case reports
https://www.readbyqxmd.com/read/28489218/percutaneous-transbiliary-biopsy
#13
Gustavo Vieira Andrade, Miguel Arcanjo Santos, Marconi Roberto Meira, Mateus Duarte Meira
Percutaneous drainage of the bile ducts is an established procedure for malignant obstructions, in which a histological diagnosis is often not obtained. We describe the biopsy technique of obstructive lesions through biliary drainage access, using a 7F endoscopic biopsy forceps, widely available; some are even reusable. This technique applies to lesions of the hepatic ducts, of the common hepatic duct and of all extension of the common bile duct. RESUMO A drenagem percutânea das vias biliares é um procedimento estabelecido para obstruções malignas, nos quais, muitas vezes, não se consegue um diagnóstico histológico...
January 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28489169/mortality-of-urgency-versus-elective-videolaparoscopic-cholecystectomy-for-acute-cholecystitis
#14
Saulo José Oliveira Felício, Ediriomar Peixoto Matos, Antonio Maurício Cerqueira, Kurt Wolfgang Schindler Freire de Farias, Ramon de Assis Silva, Mateus de Oliveira Torres
Background: Surgical approach is still controversial in patients with acute cholecystitis: to treat clinically the inflammatory process and operate electively later or to operate immediately on an emergency basis? Aim: To test the hypothesis that urgent laparoscopic cholecystectomy in acute cholecystitis has a higher mortality than elective laparoscopic cholecystectomy. Methods: From the data available in Datasus, mortality was compared between patients undergoing elective laparoscopic cholecystectomy for cholelithiasis and in urgency...
January 2017: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/28486949/a-decade-of-adverse-drug-events-in-portuguese-hospitals-space-time-clustering-and-spatial-variation-in-temporal-trends
#15
Gianina Scripcaru, Ceu Mateus, Carla Nunes
BACKGROUND: The aim of this study is to identify the distribution by municipalities of adverse drug events (ADE) in Portugal, including adverse drug reactions (ADR) and accidental poisoning by drugs (AP), on municipality/years ADE rate clustering. Also we identify areas with different trends in time. METHODS: We used a national dataset of public hospital discharges in Continental Portugal from 2004 to 2013. Events were identified based on codes: from E930 to E949...
May 10, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28481772/hiv-drug-resistance-in-africa-an-emerging-problem-that-deserves-urgent-attention
#16
Milagros Moreno, Estrella Caballero, Raquel M Mateus, Filomena Samba, Eva Gil, Vicenç Falcó
No abstract text is available yet for this article.
May 5, 2017: AIDS
https://www.readbyqxmd.com/read/28480464/breakdown-of-the-stokes-einstein-water-transport-through-narrow-hydrophobic-nanotubes
#17
Mateus Henrique Köhler, José Rafael Bordin, Leandro B da Silva, Marcia C Barbosa
In this paper the transport properties of water confined inside hydrophobic and hydrophilic nanotubes are compared for different nanotube radii and densities. While for wider nanotubes the nature of the wall plays no relevant role in the water mobility, for small nanotubes the hydrophobic confinement presents a peculiar behavior. As the density is increased the viscosity shows a huge increase associated with a small increase in the diffusion coefficient. This breakdown in the Stokes-Einstein relation for diffusion and viscosity was observed in the hydrophobic, but not in the hydrophilic nanotubes...
May 8, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28480132/osteology-of-galeamopus-pabsti-sp-nov-sauropoda-diplodocidae-with-implications-for-neurocentral-closure-timing-and-the-cervico-dorsal-transition-in-diplodocids
#18
Emanuel Tschopp, Octávio Mateus
Diplodocids are among the best known sauropod dinosaurs. Numerous specimens of currently 15 accepted species belonging to ten genera have been reported from the Late Jurassic to Early Cretaceous of North and South America, Europe, and Africa. The highest diversity is known from the Upper Jurassic Morrison Formation of the western United States: a recent review recognized 12 valid, named species, and possibly three additional, yet unnamed ones. One of these is herein described in detail and referred to the genus Galeamopus...
2017: PeerJ
https://www.readbyqxmd.com/read/28469731/integrated-data-analysis-reveals-potential-drivers-and-pathways-disrupted-by-dna-methylation-in-papillary-thyroid-carcinomas
#19
Caroline Moraes Beltrami, Mariana Bisarro Dos Reis, Mateus Camargo Barros-Filho, Fabio Albuquerque Marchi, Hellen Kuasne, Clóvis Antônio Lopes Pinto, Srikant Ambatipudi, Zdenko Herceg, Luiz Paulo Kowalski, Silvia Regina Rogatto
BACKGROUND: Papillary thyroid carcinoma (PTC) is a common endocrine neoplasm with a recent increase in incidence in many countries. Although PTC has been explored by gene expression and DNA methylation studies, the regulatory mechanisms of the methylation on the gene expression was poorly clarified. In this study, DNA methylation profile (Illumina HumanMethylation 450K) of 41 PTC paired with non-neoplastic adjacent tissues (NT) was carried out to identify and contribute to the elucidation of the role of novel genic and intergenic regions beyond those described in the promoter and CpG islands (CGI)...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28465530/defeating-bacterial-resistance-and-preventing-mammalian-cells-toxicity-through-rational-design-of-antibiotic-functionalized-nanoparticles
#20
Jessica Fernanda Affonso de Oliveira, Ângela Saito, Ariadne Tuckmantel Bido, Jörg Kobarg, Hubert Karl Stassen, Mateus Borba Cardoso
The rational synthesis of alternative materials is highly demanding due to the outbreak of infectious diseases and resistance to antibiotics. Herein, we report a tailored nanoantibiotic synthesis protocol where the antibiotic binding was optimized on the silver-silica core-shell nanoparticles surface to maximize biological responses. The obtained silver nanoparticles coated with mesoporous silica functionalized with ampicillin presented remarkable antimicrobial effects against susceptible and antibiotic-resistant Escherichia coli...
May 2, 2017: Scientific Reports
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