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https://www.readbyqxmd.com/read/28317766/first-evidences-of-interaction-between-pyranoanthocyanins-and-salivary-proline-rich-proteins
#1
Ignacio García-Estévez, Luís Cruz, Joana Oliveira, Nuno Mateus, Victor de Freitas, Susana Soares
The contribution of other classes of polyphenol compounds besides tannins to the overall perception of astringency is still poorly understood. So, this work aimed to study the interaction between a family of salivary proline-rich proteins (aPRPs) and representative pyranoanthocyanins in red wines [pyranomalvidin-3-glucoside (vitisin B), pyranomalvidin-3-glucoside-catechol, and pyranomalvidin-3-glucoside-epicatechin] using saturation transfer difference-NMR and MALDI-TOF. For vitisin B KD was of 1.74mM; for pyranomalvidin-3-glucoside-catechol was 1...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28317744/molecular-study-of-mucin-procyanidin-interaction-by-fluorescence-quenching-and-saturation-transfer-difference-std-nmr
#2
Elsa Brandão, Mafalda Santos Silva, Ignacio García-Estévez, Nuno Mateus, Victor de Freitas, Susana Soares
Astringency is closely related to the interaction between procyanidins and salivary proteins (SP). The aim of this work was to study the interaction between mucin, a SP responsible for saliva lubricating properties, with different procyanidins (B4 dimer, tetramer (TT) and fractions of oligomeric procyanidins), and the influence of several conditions [pH, ionic strength, procyanidins' mean degree of polymerization (mDP) and different solvents (ethanol or dimethylsulfoxide)] on this interaction by fluorescence quenching and Saturation Transfer Difference (STD)-NMR...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28317612/hormonal-electrolytic-and-electrocardiographic-evaluations-in-bitches-with-eutocia-and-dystocia
#3
Carla Regina Barbieri Simões, Flávia Gardilin Vassalo, Maria Lúcia Gomes Lourenço, Fabiana Ferreira de Souza, Eunice Oba, Mateus José Sudano, Nereu Carlos Prestes
The objective of the study was to assess clinical alterations, electrocardiographic, hematological, biochemical, hemogasometric, electrolytic, and hormone plasma concentrations in bitches with eutocia and dystocia. Overall, 28 bitches (dystocia, n = 22 and eutocia, n = 6) were assessed. The evaluations were performed at 2 time points, M1 (1 hour prepartum-eutocia group and cesarean or clinical intervention-dystocia group) and M2 (postpartum-eutocia or dystocia group and anesthetic recovery-dystocia group). The main clinical finding was the hypothermia (mean: 36...
December 2016: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/28303883/high-resolution-analysis-of-tropical-forest-fragmentation-and-its-impact-on-the-global-carbon-cycle
#4
Katharina Brinck, Rico Fischer, Jürgen Groeneveld, Sebastian Lehmann, Mateus Dantas De Paula, Sandro Pütz, Joseph O Sexton, Danxia Song, Andreas Huth
Deforestation in the tropics is not only responsible for direct carbon emissions but also extends the forest edge wherein trees suffer increased mortality. Here we combine high-resolution (30 m) satellite maps of forest cover with estimates of the edge effect and show that 19% of the remaining area of tropical forests lies within 100 m of a forest edge. The tropics house around 50 million forest fragments and the length of the world's tropical forest edges sums to nearly 50 million km. Edge effects in tropical forests have caused an additional 10...
March 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28302679/disrupting-androgen-receptor-signaling-induces-snail-mediated-epithelial-mesenchymal-plasticity-in-prostate-cancer
#5
Lu Miao, Lin Yang, Rui Li, Daniel Nava Rodrigues, Mateus Crespo, Jer-Tsong Hsieh, Wayne D Tilley, Johann S de Bono, Luke A Selth, Ganesh V Raj
Epithelial to mesenchymal plasticity (EMP) has been linked to metastasis, stemness, and drug resistance. In prostate cancer (PCa), EMP has been associated with both suppression and activation of androgen receptor (AR) signaling. Here we investigated the effect of the potent AR antagonist enzalutamide on EMP in multiple preclinical models of PCa and patient tissues. Enzalutamide treatment significantly enhanced the expression of EMP drivers (ZEB1, ZEB2, Snail, Twist, and FOXC2) and mesenchymal markers (N-cadherin, fibronectin, and vimentin) in PCa cells, enhanced PCa cell migration, and induced PCa transformation to a spindle, fibroblast-like morphology...
March 16, 2017: Cancer Research
https://www.readbyqxmd.com/read/28302409/effectiveness-of-2009-pandemic-influenza-a-h1n1-vaccines-a-systematic-review-and-meta-analysis
#6
REVIEW
Louise E Lansbury, Sherie Smith, Walter Beyer, Emina Karamehic, Eva Pasic-Juhas, Hana Sikira, Ana Mateus, Hitoshi Oshitani, Hongxin Zhao, Charles R Beck, Jonathan S Nguyen-Van-Tam
BACKGROUND: The clinical effectiveness of monovalent influenza A(H1N1)pdm09 vaccines has not been comprehensively summarised. We undertook a systematic review and meta-analysis to assess vaccine effectiveness (VE) for adjuvanted and unadjuvanted vaccines. METHODS: We searched healthcare databases and grey literature from 11 June 2009 to 12 November 2014. Two researchers independently assessed titles and abstracts to identify studies for full review. Random effects meta-analyses estimated the pooled effect size of vaccination compared to placebo or no vaccination for crude and adjusted odds ratios (OR) to prevent laboratory confirmed influenza illness (LCI) and related hospitalization...
March 14, 2017: Vaccine
https://www.readbyqxmd.com/read/28293288/techno-economic-analysis-and-climate-change-impacts-of-sugarcane-biorefineries-considering-different-time-horizons
#7
Tassia L Junqueira, Mateus F Chagas, Vera L R Gouveia, Mylene C A F Rezende, Marcos D B Watanabe, Charles D F Jesus, Otavio Cavalett, Artur Y Milanez, Antonio Bonomi
BACKGROUND: Ethanol production from lignocellulosic feedstocks (also known as 2nd generation or 2G ethanol process) presents a great potential for reducing both ethanol production costs and climate change impacts since agricultural residues and dedicated energy crops are used as feedstock. This study aimed at the quantification of the economic and environmental impacts considering the current and future scenarios of sugarcane biorefineries taking into account not only the improvements of the industrial process but also of biomass production systems...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28293254/multiple-uses-of-fibrin-sealant-for-nervous-system-treatment-following-injury-and-disease
#8
REVIEW
Natalia Perussi Biscola, Luciana Politti Cartarozzi, Suzana Ulian-Benitez, Roberta Barbizan, Mateus Vidigal Castro, Aline Barroso Spejo, Rui Seabra Ferreira, Benedito Barraviera, Alexandre Leite Rodrigues Oliveira
Lesions to the nervous system often produce hemorrhage and tissue loss that are difficult, if not impossible, to repair. Therefore, scar formation, inflammation and cavitation take place, expanding the lesion epicenter. This significantly worsens the patient conditions and impairment, increasing neuronal loss and glial reaction, which in turn further decreases the chances of a positive outcome. The possibility of using hemostatic substances that also function as a scaffold, such as the fibrin sealant, reduces surgical time and improve postoperative recovery...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28291258/adult-hippocampal-neuroplasticity-triggers-susceptibility-to-recurrent-depression
#9
N D Alves, J S Correia, P Patrício, A Mateus-Pinheiro, A R Machado-Santos, E Loureiro-Campos, M Morais, J M Bessa, N Sousa, L Pinto
Depression is a highly prevalent and recurrent neuropsychiatric disorder associated with alterations in emotional and cognitive domains. Neuroplastic phenomena are increasingly considered central to the etiopathogenesis of and recovery from depression. Nevertheless, a high number of remitted patients experience recurrent episodes of depression, remaining unclear how previous episodes impact on behavior and neuroplasticity and/or whether modulation of neuroplasticity is important to prevent recurrent depression...
March 14, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28273955/lack-of-xpc-leads-to-a-shift-between-respiratory-complexes-i-and-ii-but-sensitizes-cells-to-mitochondrial-stress
#10
Mateus P Mori, Rute A P Costa, Daniela T Soltys, Thiago de S Freire, Franco A Rossato, Ignácio Amigo, Alicia J Kowaltowski, Aníbal E Vercesi, Nadja C de Souza-Pinto
Genomic instability drives tumorigenesis and DNA repair defects are associated with elevated cancer. Metabolic alterations are also observed during tumorigenesis, although a causal relationship between these has not been clearly established. Xeroderma pigmentosum (XP) is a DNA repair disease characterized by early cancer. Cells with reduced expression of the XPC protein display a metabolic shift from OXPHOS to glycolysis, which was linked to accumulation of nuclear DNA damage and oxidants generation via NOX-1...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28273086/two-new-ootaxa-from-the-late-jurassic-the-oldest-record-of-crocodylomorph-eggs-from-the-lourinh%C3%A3-formation-portugal
#11
João Russo, Octávio Mateus, Marco Marzola, Ausenda Balbino
The Late Jurassic Lourinhã Formation is known for its abundant remains of dinosaurs, crocodylomorphs and other vertebrates. Among this record are nine localities that have produced either dinosaur embryos, eggs or eggshell fragments. Herein, we describe and identify the first crocodiloid morphotype eggs and eggshells from the Lourinhã Formation, from five occurrences. One clutch from Cambelas, composed of 13 eggs, eggshell fragments from Casal da Rola and Peralta, one crushed egg and eggshells from Paimogo North, and four crushed eggs as well as eggshell fragments from Paimogo South...
2017: PloS One
https://www.readbyqxmd.com/read/28270135/is-cancer-a-pure-growth-curve-or-does-it-follow-a-kinetics-of-dynamical-structural-transformation
#12
Maraelys Morales González, Javier Antonio González Joa, Luis Enrique Bergues Cabrales, Ana Elisa Bergues Pupo, Baruch Schneider, Suleyman Kondakci, Héctor Manuel Camué Ciria, Juan Bory Reyes, Manuel Verdecia Jarque, Miguel Angel O'Farril Mateus, Tamara Rubio González, Soraida Candida Acosta Brooks, José Luis Hernández Cáceres, Gustavo Victoriano Sierra González
BACKGROUND: Unperturbed tumor growth kinetics is one of the more studied cancer topics; however, it is poorly understood. Mathematical modeling is a useful tool to elucidate new mechanisms involved in tumor growth kinetics, which can be relevant to understand cancer genesis and select the most suitable treatment. METHODS: The classical Kolmogorov-Johnson-Mehl-Avrami as well as the modified Kolmogorov-Johnson-Mehl-Avrami models to describe unperturbed fibrosarcoma Sa-37 tumor growth are used and compared with the Gompertz modified and Logistic models...
March 7, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28263419/transoral-ultrasonic-surgery-of-pharyngolaryngeal-giant-hemangioma-after-ethylene-vinyl-alcohol-copolymer-onyx-embolization
#13
Meritxell Valls-Mateus, Luis San Román, Juan Macho, Alfons Nadal, Manuel Bernal-Sprekelsen, Isabel Vilaseca
BACKGROUND: Cervico-mediastinal hemangiomas in adulthood are rare and slow-growing vascular tumors. The optimal treatment for giant hemangiomas is controversial. In asymptomatic cases, clinical observation is generally recommended. METHODS: We report the transoral resection of a pharyngolaryngeal hemangioma (diameters of 44 × 56 × 39 mm) with tracheal involvement and mediastinal extension. Clinically, the patient had throat foreign body sensation, severe dyspnea and stridor...
March 6, 2017: Head & Neck
https://www.readbyqxmd.com/read/28258194/antiparasitic-treatment-induces-an-improved-cd8-t-cell-response-in-chronic-chagasic-patients
#14
Jose Mateus, Elena Pérez-Antón, Paola Lasso, Adriana Egui, Nubia Roa, Bartolomé Carrilero, John M González, M Carmen Thomas, Concepción J Puerta, Manuel C López, Adriana Cuéllar
Chagas disease is a chronic infection caused by Trypanosoma cruzi, an intracellular protozoan parasite. Chronic chagasic patients (CCPs) have dysfunctional CD8(+) T cells that are characterized by impaired cytokine production, high coexpression of inhibitory receptors, and advanced cellular differentiation. Most patients diagnosed in the chronic phase of Chagas disease already exhibit heart involvement, and there is no vaccination that protects against the disease. Antiparasitic treatment is controversial as to its indication for this stage of the disease...
March 3, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28254717/a-pioneering-study-on-cytotoxicity-in-australian-parakeets-melopsittacus-undulates-exposed-to-tannery-effluent
#15
Joyce Moreira de Souza, Mateus Flores Montalvão, Anderson Rodrigo da Silva, Aline Sueli de Lima Rodrigues, Guilherme Malafaia
Waste effluent from the tannery industry is a major source of environmental pollution. Considering that the bird intake of water contaminated with tannery effluent constitutes a potential genotoxic source, especially for birds inhabiting areas closest to tanning industries, the aim of this study is to assess the possible mutagenic effects that the intake may have on Melopsittacus undulatus (Australian parakeet). In order to do so, adult male and female M. undulatus were distributed in two experimental groups: control (drinking water) and TE (5%)...
May 2017: Chemosphere
https://www.readbyqxmd.com/read/28251854/interaction-between-wine-phenolic-acids-and-salivary-proteins-by-saturation-transfer-difference-nuclear-magnetic-resonance-spectroscopy-std-nmr-and-molecular-dynamics-simulations
#16
Raúl Ferrer-Gallego, José Miguel Hernández-Hierro, Natércia F Brás, Nuno Vale, Paula Gomes, Nuno Mateus, Victor de Freitas, Francisco J Heredia, María Teresa Escribano-Bailón
The interaction between phenolic compounds and salivary proteins is highly related to the astringency perception. Recently, it has been proven the existence of synergisms on the perceived astringency when phenolic acids were tested as mixtures in comparison to individual compounds, maintaining constant the total amount of the stimulus. The interactions between wine phenolic acids and the peptide fragment IB712 have been studied by saturation-transfer difference (STD) NMR spectroscopy. This technique provided the dissociation constants and the percentage of interaction between both individual and mixtures of hydroxybenzoic and hydroxycinnamic acids and the model peptide...
March 10, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28247034/genomic-characteristics-of-trastuzumab-resistant-her2-positive-metastatic-breast-cancer
#17
Mateus de Oliveira Taveira, Sheida Nabavi, Yuker Wang, Peter Tonellato, Francisco J Esteva, Lewis C Cantley, Gerburg M Wulf
PURPOSE: Resistance to trastuzumab therapy is linked to phosphoinositol 3-kinase (PI3K) pathway activation. One key downstream effector and regulator of this pathway is the mechanistic target of rapamycin (mTOR). In 2011, a phase I/II study evaluated the combination of trastuzumab and everolimus (a mTOR inhibitor) for treatment of Her2-positive metastatic breast cancer (MBC) for patients who had progressed on trastuzumab-based therapy. METHODS: We retrospectively analyzed GeneChip microarray data from 22 of 47 patients included in the study...
February 28, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28245688/treatment-of-prescription-opioid-use-disorder-in-pregnant-women
#18
Constance Guille, Kelly S Barth, Julio Mateus, Jenna L McCauley, Kathleen T Brady
No abstract text is available yet for this article.
March 1, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28242355/activities-of-ectonucleotidases-and-adenosine-deaminase-in-platelets-of-cattle-experimentally-infected-by-fasciola-hepatica
#19
Mateus Fracasso, Aleksandro S Da Silva, Matheus D Baldissera, Nathieli B Bottari, Mateus E Gabriel, Manoela M Piva, Fernanda A Stedille, Ricardo Christ, Leandro A Rhoden, Luan C Henker, Vera M Moresch, Maria Rosa C Schetinger, Ricardo E Mendes
The enzymatic activities of NTPDase, 5'-nucleotidase and adenosine deaminase (ADA) are important in regulating the concentration of adenine nucleotides, molecules known to be involved on platelet aggregation. Fasciolosis causes coagulation disorders that have not been completely elucidated. Taking into consideration the association between the purinergic system and hemostasis, this study aimed to evaluate the enzymatic activities of NTPDase (hydrolyze ATP and ADP), 5'-nucleotidase (hydrolyze AMP) and ADA (deamination of adenosine) in platelets from cattle experimentally infected by Fasciola hepatica on days 20, 40, 60 and 80 post-infection (PI)...
February 24, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28225057/intracellular-drug-bioavailability-a-new-predictor-of-system-dependent-drug-disposition
#20
André Mateus, Andrea Treyer, Christine Wegler, Maria Karlgren, Pär Matsson, Per Artursson
Intracellular drug exposure is influenced by cell- and tissue-dependent expression of drug-transporting proteins and metabolizing enzymes. Here, we introduce the concept of intracellular bioavailability (Fic) as the fraction of extracellular drug available to bind intracellular targets, and we assess how Fic is affected by cellular drug disposition processes. We first investigated the impact of two essential drug transporters separately, one influx transporter (OATP1B1; SLCO1B1) and one efflux transporter (P-gp; ABCB1), in cells overexpressing these proteins...
February 22, 2017: Scientific Reports
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