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https://www.readbyqxmd.com/read/29139338/freeze-drying-of-silica-nanoparticles-redispersibility-toward-nanomedicine-applications
#1
Agustin S Picco, Larissa F Ferreira, Michelle S Liberato, Gabriela B Mondo, Mateus B Cardoso
AIM: To study freeze-drying of silica nanoparticles (SiO2NPs) in order to find suitable conditions to produce lyophilized powders with no aggregation after resuspension and storage. METHODS: SiO2NPs were synthesized using a Stöber-based procedure, and characterized by scanning electron microscopy, dynamic light scattering and nitrogen adsorption/desorption isotherms. SiO2NPs hydrodynamic diameters were compared prior and after freeze-drying in the presence/absence of carbohydrate protectants...
November 15, 2017: Nanomedicine
https://www.readbyqxmd.com/read/29132333/oestrogen-receptor-beta-isoform-expression-in-sporadic-colorectal-cancer-familial-adenomatous-polyposis-and-progressive-stages-of-colorectal-cancer
#2
Paulo Roberto Stevanato Filho, Samuel Aguiar Júnior, Maria Dirlei Begnami, Hellen Kuasne, Ranyell Matheus Spencer, Wilson Toshihiko Nakagawa, Tiago Santoro Bezerra, Bruna Catin Kupper, Renata Maymi Takahashi, Mateus Barros Filho, Silvia Regina Rogatto, Ademar Lopes
BACKGROUND: Among the sex hormones, oestrogen may play a role in colorectal cancer, particularly in conjunction with oestrogen receptor-β (ERβ). The expression of ERβ isoform variants and their correlations with familial adenomatous polyposis (FAP) syndrome and sporadic colorectal carcinomas are poorly described. METHODS: This study aimed to investigate the expression levels of the ERβ1, ERβ2, ERβ4 and ERβ5 isoform variants using quantitative RT-PCR (921 analyses) in FAP, normal mucosa, adenomatous polyps and sporadic colorectal carcinomas...
November 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29130698/preoperative-metabolic-status-is-associated-with-different-evolution-of-resting-energy-expenditure-after-liver-transplant-in-adults
#3
Ana Brito-Costa, Luís Pereira-da-Silva, Ana Luisa Papoila, Marta Alves, Élia Mateus, Fernando Nolasco, Eduardo Barroso
INTRODUCTION: The resting energy expenditure (REE) evolution after liver transplantation is not fully understood. OBJECTIVE: To assess longitudinally the REE evolution in adults undergoing liver transplantation, in association with other nutritional measurements that characterize the metabolic profile. METHODS: A single-center cohort of consecutive end-stage liver disease patients with indication for liver transplantation was recruited. REE, subjective global assessment (SGA), handgrip strength and body composition measurements were assessed before transplantation (T0) and at median nine (T1) and 36 (T2) days after transplantation...
October 24, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29130483/contributions-of-infant-vagal-regulation-at-1-month-to-subsequent-joint-attention-abilities
#4
Vera Mateus, Sara Cruz, Fernando Ferreira-Santos, Ana Osório, Adriana Sampaio, Carla Martins
Since birth, humans develop an ability to regulate their inner states and behaviors, when facing demanding situations, in order to restore calmness and engage with other persons and the surrounding environment. The present study analyzed whether 1-month infant vagal regulation to auditory stimuli was associated with later joint attention abilities-responding to and initiating joint attention-in interaction with their mothers. Twenty-three infants were assessed and measures of respiratory sinus arrhythmia-RSA (baseline and vagal tone change during auditory stimulation) were used as index of vagal regulation...
November 12, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/29127992/leishmania-infantum-exerts-immunomodulation-in-canine-kupffer-cells-reverted-by-meglumine-antimoniate
#5
A Rodrigues, D Santos-Mateus, G Alexandre-Pires, A Valério-Bolas, M Rafael-Fernandes, M A Pereira, D Ligeiro, J de Jesus, R Alves-Azevedo, S Lopes-Ventura, M Santos, A M Tomás, I Pereira da Fonseca, G Santos-Gomes
Kupffer cells (KC) are the liver macrophage population that resides in the hepatic sinusoids and efficiently phagocyte pathogens by establishing an intimate contact with circulating blood. KC constitute the liver host cells in Leishmania infection, nevertheless little is described about their role, apart from their notable contribution in granulomatous inflammation. The present study aims to investigate how canine KC sense and react to the presence of Leishmania infantum promastigotes and amastigotes by evaluating the gene expression of specific innate immune cell receptors and cytokines, as well as the induction of nitric oxide and urea production...
December 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/29127630/analysis-of-various-effects-of-abamectin-on-erythrocyte-morphology-in-japanese-quails-coturnix-japonica
#6
Denise Braga Gomes de Faria, Mateus Flores Montalvão, Joyce Moreira de Souza, Bruna de Oliveira Mendes, Guilherme Malafaia, Aline Sueli de Lima Rodrigues
Although previous studies have already confirmed the toxicological potential of abamectin (ABA) in different experimental models (from invertebrates to vertebrates), almost nothing is known about the impacts the exposure to this pesticide can cause on birds. Thus, the aim of our study is to investigate the cytotoxic effects on the erythrocytes of female Japanese quails (Coturnix japonica) exposed to low abamectin concentrations. In order to do so, three experimental groups were proposed: "control," composed of quails exposed to abamectin-free drinking water; "ABA 1% median lethal dose (LD50)," comprising birds exposed to water containing 15...
November 10, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29121494/being-a-mother-of-preterm-multiples-in-the-context-of-socioeconomic-disadvantage-perceived-stress-and-psychological-symptoms
#7
Joana Baptista, Vanessa Moutinho, Vera Mateus, Hercília Guimarães, Fátima Clemente, Sara Almeida, Maria Agostinha Andrade, Clara Paz Dias, Alice Freitas, Carla Martins, Isabel Soares
OBJECTIVE: This study aimed to examine the differences between mothers of preterm multiples and mothers of preterm singletons regarding perceived stress and maternal psychological symptoms, and to explore the putative adverse amplified effect of socioeconomic disadvantage. METHOD: Ninety-five mothers of 1-year-olds born preterm participated in this cross-sectional study. Data collection was carried out in two public hospitals from Northern Portugal. To assess maternal perceived daily stress and psychological symptoms, mothers completed two questionnaires...
November 6, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/29109428/serial-omics-of-p53-brca1-mouse-breast-tumor-and-normal-mammary-gland
#8
Susanne B Breitkopf, Mateus De Oliveira Taveira, Min Yuan, Gerburg M Wulf, John M Asara
This study demonstrates a liquid-liquid extraction for the sequential tandem mass spectrometry (LC-MS/MS) analysis of non-polar lipids, polar metabolites, proteins and phosphorylation sites from a single piece of tissue. Extraction of 10 mg BRCA-/-, p53-/- breast tumor tissue or normal mammary gland tissue with methyl-tert-butyl ether (MTBE) results in three phases: an upper non-polar phase containing 1,382 lipids, a lower polar phase with 805 metabolites and a precipitated protein pellet with 4,792 proteins with 1,072 phosphorylation sites...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29109320/effects-of-the-ratio-between-pigment-and-bleaching-gel-on-the-fracture-resistance-and-dentin-microhardness-of-endodontically-treated-teeth
#9
Marina Og Galloza, Keren Cf Jordão-Basso, Matheus C Bandeca, Samuel O Costa, Alvaro H Borges, Mateus R Tonetto, Fabio C Tirintan, Kátia C Keine, Milton C Kuga
INTRODUCTION: The aim of this study was to evaluate the effects of bleaching gel using 35% hydrogen peroxide (HP), associated with red carmine pigment (RC), in the 3:1 or 1:1 ratio, on fracture resistance and dentin microhardness of endodontically treated teeth. MATERIALS AND METHODS: A total of 40 lower incisors were endodontically treated and divided into four groups (n = 10), according to the bleaching protocol: G1 (HP3), 35% HP + RC (3:1); G2 (HP1), 35% HP + RC (1:1); G3 (positive), 38% HP; and G4 (negative), unbleached...
November 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29107355/spatial-compounding-of-3-d-fetal-brain-ultrasound-using-probabilistic-maps
#10
Jorge Perez-Gonzalez, Fernando Arámbula-Cosío, Mario Guzmán, Lisbeth Camargo, Benjamin Gutierrez, Diana Mateus, Nassir Navab, Verónica Medina-Bañuelos
A new method to address the problem of shadowing in fetal brain ultrasound volumes is presented. The proposed approach is based on the spatial composition of multiple 3-D fetal head projections using the weighted Euclidean norm as an operator. A support vector machine, which is trained with optimal textural features, was used to assign weighting according to the posterior probabilities of brain tissue and shadows. Both phantom and real fetal head ultrasound volumes were compounded using previously reported operators and compared with the proposed composition method to validate it...
October 26, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29107209/phkv-a-toxin-isolated-from-the-spider-venom-induces-antinociception-by-inhibition-of-cholinesterase-activating-cholinergic-system
#11
Flavia Karine Rigo, Mateus Fortes Rossato, Gabriela Trevisan, Samira Dal-Toé De Prá, Rafael Porto Ineu, Mariane Bernardo Duarte, Célio José de Castro Junior, Juliano Ferreira, Marcus Vinicius Gomez
BACKGROUND AND AIMS: Cholinergic agents cause antinociception by mimicking the release of acetylcholine (ACh) from spinal cholinergic nerves. PhKv is a peptide isolated from the venom of the armed spider Phoneutria nigriventer. It has an antiarrythmogenic activity that involves the enhanced release of acetylcholine. The aim of this study was to investigate whether PhKv had an antinociceptive action in mice. METHODS: Male albino Swiss mice (25-35g) were used in this study...
October 26, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29101708/dose-response-effect-of-photobiomodulation-therapy-on-neuromuscular-economy-during-submaximal-running
#12
Rodolfo André Dellagrana, Mateus Rossato, Raphael Luiz Sakugawa, Caetano Decian Lazzari, Bruno Manfredini Baroni, Fernando Diefenthaeler
The purpose of this study was to verify the photobiomodulation therapy (PBMT) effects with different doses on neuromuscular economy during submaximal running tests. Eighteen male recreational runners participate in a randomized, double-blind, and placebo-controlled trial, which each participant was submitted to the same testing protocol in five conditions: control, placebo, and PBMT with doses of 15, 30, and 60 J per site (14 sites in each lower limb). The submaximal running was performed at 8 and 9 km h(-1) during 5 min for each velocity...
November 3, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29099819/an-educational-strategy-that-promotes-healthy-habits-in-elderly-people-with-hypertension-in-a-municipality-of-colombia-a-participatory-action-research-study
#13
María Carolina López-Mateus, Erwin Hernando Hernández-Rincón, Camilo Alejandro Correal-Muñoz, Gina Paola Cadena-Buitrago, Ingrid Johanna Galvis-Díaz, Génesis Esmeralda Romero-Prieto
OBJECTIVE: To identify resources of the municipality of Sopó-Cundinamarca, Colombia, that are also opportunities to strengthen the development of an educational strategy that promotes healthy habits (healthy diet and exercise) as part of the comprehensive management of hypertension in the elderly. METHODS: A qualitative study of a participatory-action research initiative in the Community Day Center of Sopó in the second semester of 2015. It was developed in three stages: first, a community diagnosis showed the need to integrate the culture, traditions and resources of the municipality as inputs that allow the adherence of healthy styles by the elderly for the control of hypertension; in the second stage, a work plan was established based on actions provided by the community; and in the third stage, we reflected on the results...
October 30, 2017: Medwave
https://www.readbyqxmd.com/read/29098946/are-antibiotic-functionalized-nanoparticles-a-promising-tool-in-antimicrobial-therapies
#14
Jessica Fernanda Affonso de Oliveira, Larissa Brentano Capeletti, Mateus Borba Cardoso
No abstract text is available yet for this article.
November 3, 2017: Nanomedicine
https://www.readbyqxmd.com/read/29097830/speed-sintering-translucent-zirconia-for-chairside-one-visit-dental-restorations-optical-mechanical-and-wear-characteristics
#15
Marina R Kaizer, Petra C Gierthmuehlen, Mateus Bf Dos Santos, Sergio S Cava, Yu Zhang
The fabrication of zirconia dental restorations is a time-consuming process due to traditional slow sintering schemes; zirconia (Y-TZP) produced by these conventional routes are predominantly opaque. Novel speed sintering protocols have been developed to meet the demand for time and cost effective chairside CAD/CAM-produced restorations, as well as to control ceramic microstructures for better translucency. Although the speed sintering protocols have already been used to densify dental Y-TZP, the wear properties of these restorations remain elusive...
October 1, 2017: Ceramics International
https://www.readbyqxmd.com/read/29093500/shape-tailored-magnetic-nanorings-for-intracellular-hyperthermia-cancer-therapy
#16
Carlos S B Dias, Talita D M Hanchuk, Heberton Wender, Willian T Shigeyosi, Jörg Kobarg, André L Rossi, Marcelo N Tanaka, Mateus B Cardoso, Flávio Garcia
This work explores a new class of vortex/magnetite/iron oxide nanoparticles designed for magnetic hyperthermia applications. These nanoparticles, named Vortex Iron oxide Particles (VIPs), are an alternative to the traditional Superparamagnetic Iron Oxide Nanoparticles (SPIONs), since VIPs present superior heating power while fulfilling the main requirements for biomedical applications (low cytotoxicity and nonremanent state). In addition, the present work demonstrates that the synthesized VIPs also promote an internalization and aggregation of the particles inside the cell, resulting in a highly localized hyperthermia in the presence of an alternating magnetic field...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29083057/convenient-enzymatic-resolution-of-r-s-2-methylbutyric-acid-catalyzed-by-immobilized-lipases
#17
Mateus Mittersteiner, Bruna Luiza Linshalm, Ana Paula Furlan Vieira, Patrícia Bulegon Brondani, Dilamara Riva Scharf, Paulo Cesar de Jesus
The application of several immobilized lipases has been explored in the enantioselective esterification of (R,S)-2-methylbutyric acid, an insect pheromone precursor. With the use of Candida antarctica B, using hexane as solvent, (R)-pentyl 2-methylbutyrate was prepared in 2 h with c 40%, eep 90%, and E = 35, while Thermomyces lanuginosus leads to c 18%, eep 91%, and E = 26. The (S)-enantiomer was obtained by the use of Candida rugosa or Rhizopus oryzae (2-h reaction, c 34% and 35%, eep 75 and 49%, and E = 10 and 4, respectively)...
October 30, 2017: Chirality
https://www.readbyqxmd.com/read/29080044/metformin-effect-on-tsh-in-subclinical-hypothyroidism-randomized-double-blind-placebo-controlled-clinical-trial
#18
Mateus Dornelles Severo, Thais Stürmer Andrade, Vicente Correa Junior, Alexandre Antonio Naujorks, Miguel Gus, Beatriz D Schaan
INTRODUCTION: Non-randomized trials suggest that metformin may reduce TSH levels through unknown mechanisms. OBJECTIVE: To evaluate whether metformin can reduce TSH levels in subjects with subclinical hypothyroidism. PATIENTS AND METHODS: This is a randomized, double-blind, placebo controlled clinical trial with 3 months duration that enrolled 48 individuals, between 18 and 65 years, with subclinical hypothyroidism. The patients were randomized to the use of metformin 850 mg or placebo twice a day for 3 months...
October 27, 2017: Endocrine
https://www.readbyqxmd.com/read/29073918/a-first-description-of-the-colombian-national-registry-for-rare-diseases
#19
Heidi Eliana Mateus, Ana María Pérez, Martha Lucía Mesa, Germán Escobar, Jubby Marcela Gálvez, José Ivo Montaño, Martha Lucía Ospina, Paul Laissue
OBJECTIVE: Orphan diseases must be considered a public health concern, underlying country-specific challenges for their accurate and opportune diagnosis, classification and management. Orphan disease registries have not yet been created in South America, a continent having a population of ~ 415 million inhabitants. In Colombia ~ 3 million of patients are affected by rare diseases. The aim of the present study was to establish the first Colombian national registry for rare diseases. The registry was created after the establishment of laws promoting the development of clinical guidelines for diagnosis, management, census and registry of patients suffering rare diseases...
October 26, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29069204/cardiac-metabolic-and-molecular-profiles-of-sedentary-rats-in-the-initial-moment-of-obesity
#20
Bruno Barcellos Jacobsen, Ana Paula Lima Leopoldo, Jóctan Pimentel Cordeiro, Dijon Henrique Salomé de Campos, André Ferreira do Nascimento, Mário Mateus Sugizaki, Antônio Carlos Cicogna, Carlos Roberto Padovani, André Soares Leopoldo
BACKGROUND: Different types of high-fat and/or high-energy diets have been used to induce obesity in rodents. However, few studies have reported on the effects observed at the initial stage of obesity induced by high-fat feeding on cardiac functional and structural remodelling. OBJECTIVE: To characterize the initial moment of obesity and investigate both metabolic and cardiac parameters. In addition, the role of Ca2+ handling in short-term exposure to obesity was verified...
October 19, 2017: Arquivos Brasileiros de Cardiologia
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