David C McGiffin, Christina E Kure, Peter S Macdonald, Paul C Jansz, Sam Emmanuel, Silvana F Marasco, Atsuo Doi, Chris Merry, Robert Larbalestier, Amit Shah, Agneta Geldenhuys, Amul K Sibal, Cara A Wasywich, Jacob Mathew, Eldho Paul, Caitlin Cheshire, Angeline Leet, James L Hare, Sandra Graham, John F Fraser, David M Kaye
BACKGROUND: Cold static storage (CSS) preservation of donor hearts for periods longer than 4 hours increases the risk of primary graft dysfunction (PGD). The aim of the study was to determine if hypothermic oxygenated perfusion (HOPE) could safely prolong the preservation time of donor hearts. METHODS: We conducted a non-randomised, single arm, multi-center investigation of the effect of HOPE using the XVIVO Heart Preservation System on donor hearts with a projected preservation time of 6-8 hours on 30-day recipient survival and allograft function post-transplant...
October 31, 2023: Journal of Heart and Lung Transplantation