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Ischemia uterus

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https://www.readbyqxmd.com/read/28805600/the-effect-of-oxytocin-and-kisspeptin-10-in-ovary-and-uterus-of-ischemia-reperfusion-injured-rats
#1
M Aslan, G Erkanli Senturk, H Akkaya, S Sahin, B Yılmaz
OBJECTIVE: Ischemia/reperfusion (I/R) injuries result in damage to endothelial and parenchymal cells. Oxytocin (OXY) stimulates uterine contraction during parturition and myoepithelial cells during suckling. OXY has been used as a protective antioxidant. Kisspeptin plays a key role in the central control of reproductive functions and onset of puberty. Recent studies show that these reproductive hormones have protective potential as antioxidant. The aim of this study is to investigate the potential protective effects of Kisspeptin and OXY as antioxidants on I/R injured ovary and uterus of female rats...
August 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28626073/increased-vascular-and-uteroplacental-matrix-metalloproteinase-1-and-7-levels-and-collagen-i-deposition-in-hypertension-in-pregnancy-role-of-tnf
#2
Wei Li, Ning Cui, Marc Q Mazzuca, Karina M Mata, Raouf A Khalil
Preeclampsia is manifested as maternal hypertension-in-pregnancy (HTN-Preg) and fetal growth restriction. Placental ischemia could be an initiating event; however, the molecular targets and intermediary mechanisms are unclear. We tested the hypothesis that placental ischemia could target vascular and uteroplacental matrix metalloproteinases (MMPs) through cytokines-mediated mechanism. MMP levels and distribution were measured in aorta, uterus and placenta of normal pregnant rats (Preg), and pregnant rats with reduced uterine perfusion pressure (RUPP)...
June 16, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28624353/expression-of-hypoxia-inducible-factor-1%C3%AE-and-antioxidant-enzymes-superoxide-dismutases-1-and-2-in-ischemic-porcine-endometrium
#3
Joanna Kwiatkowska, Barbara Wąsowska, Przemysław Gilun
The aim of this study was to determine how 60-min ischemia changes the expression of hypoxia inducible factor 1α (HIF-1α) and superoxide dismutases (SOD)-1 and -2 in selected regions of porcine uterine horns. The results showed that 60-min ischemia of the porcine uterus conducted at the mid-secretory estrous phase caused decreased HIF-1α and increased SOD-2 gene expression. Higher expression of SOD-2 suggests that this enzyme may play an important role in the suppression of HIF-1α accumulation in an ischemic endometrium...
June 14, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/28535402/uterus-tolerance-to-extended-cold-ischemic-storage-after-auto-transplantation-in-ewes
#4
Jérémy Tricard, Sébastien Ponsonnard, Yannick Tholance, Laura Mesturoux, Denis Lachatre, Claude Couquet, Faraj Terro, Catherine Yardin, Pierre Marquet, Alessandro Piccardo, Tristan Gauthier
OBJECTIVE: To assess how the uterus tolerates extended cold ischemic storage before auto-transplantation in ewes. STUDY DESIGN: Fourteen uterine auto-transplantations were performed in ewes from November 2014 to June 2015 at the Analysis and Research Laboratory of Limoges, France. The animals were divided into 2 groups: 7 after 3h of cold ischemia timeand 7 after 24h. Transplant was assessed ≥8days after transplantation. Histology and apoptosis analyses (TUNEL method and indirect immunohistochemistry of cleaved Caspase 3) were performed before uterus retrieval (control), after 90min following reperfusion and ≥8days after transplantation...
May 16, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28506758/decreased-homodimerization-and-increased-timp-1-complexation-of-uteroplacental-and-uterine-arterial-matrix-metalloproteinase-9-during-hypertension-in-pregnancy
#5
Juanjuan Chen, Zongli Ren, Minglin Zhu, Raouf A Khalil
Preeclampsia is a complication of pregnancy manifested as hypertension-in-pregnancy (HTN-Preg) and often intrauterine growth restriction (IUGR). Placental ischemia could be an initiating event, but the molecular mechanisms are unclear. To test the hypothesis that dimerization of matrix metalloproteinases (MMPs) plays a role in HTN-Preg and IUGR, the levels/activity of MMP-9, tissue inhibitor of metalloproteinase (TIMP-1), and their dimerization forms were measured in the placenta, uterus, and uterine artery of normal pregnant (Preg) rats and a rat model of reduced uteroplacental perfusion pressure (RUPP)...
August 15, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28406930/eutopic-ectopic-endometrial-apoptosis-initiated-by-bilateral-uterine-artery-occlusion-a-new-therapeutic-mechanism-for-uterus-sparing-surgery-in-adenomyosis
#6
Li Chen, Caixia Li, Jing Guo, Ning Luo, Xiaoyan Qu, Le Kang, Mingmin Liu, Zhongping Cheng
The objective of the present study was to investigate differences in the expression of apoptosis-related factors in the eutopic and ectopic endometrium (EuE/EE) in women with adenomyosis before and after laparoscopic bilateral uterine artery occlusion (LUAO). Ten patients with uterine adenomyosis who received LUAO were selected as the research subjects, from whom EuE and EE tissues were obtained before and after LUAO and detected for the expression of apoptosis-related molecules in EuE and EE by PT-PCR and Western blot, and changes in the mitochondrial structure by electron microscopy...
2017: PloS One
https://www.readbyqxmd.com/read/28376665/thinking-outside-the-box
#7
Judith Ingles, Chandrashekara N Kyathanahalli, Pancharatnam Jeyasuria, Jennifer C Condon
A broad definition of preconditioning is "the preparation for a subsequent action." Mounting evidence demonstrates that novel remote preconditioning paradigms, in which protective stimuli experienced locally can capacitate systemic tolerance and enhanced cell viability upon exposure to ensuing cellular insults, have been largely successful in the field of cardiovascular ischemia/reperfusion injury. To ensure successful protective preconditioning, some models (including the uterus) have been demonstrated to activate the unfolded protein response (UPR), which is a cellular stress response controlled at the level of the endoplasmic reticulum...
July 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28273748/the-effects-of-uterine-artery-embolization-with-a-new-degradable-microsphere-in-an-experimental-study
#8
Johan Bengtsson, Wojciech Cwikiel, Pia C Sundgren, Erika Karlstam, Dolores Gavier-Widén, Inger Keussen
Background Transarterial particle embolization is a common treatment of uterine fibroids, aiming to obtain ischemia resulting in shrinking of the fibroid with preservation of normal uterine tissue. Embolization with non-degradable microspheres is established, but causes permanent occlusion of the arteries, affecting both the uterus as well as the fibroids. Purpose To evaluate in vivo degradation, local tissue effects, and possible recanalization following intra-arterial deposition of the new, degradable starch microspheres (DSM), in a short-term experimental pilot study...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28236104/uterine-fibroid-therapy-using-interventional-radiology-mini-invasive-treatments-current-perspective
#9
REVIEW
Carlo Masciocchi, Francesco Arrigoni, Fabiana Ferrari, Aldo Victor Giordano, Sonia Iafrate, Ilaria Capretti, Ester Cannizzaro, Alfonso Reginelli, Anna Maria Ierardi, Chiara Floridi, Alessio Salvatore Angileri, Luca Brunese, Antonio Barile
Uterine fibroids are common benign tumors of unclear etiopathology that affect the female reproductive tract. They are responsible for considerable morbidity and deterioration of life quality, and may have a negative impact on the reproductive system as well. Besides surgery aided by uterus-saving techniques, several minimally invasive procedures are now available within the field of interventional radiology that represent a valid solution for women who desire pregnancy and relief from disease-specific symptomatology...
April 2017: Medical Oncology
https://www.readbyqxmd.com/read/28157642/cervicovaginal-agenesis-treated-with-modified-yang-monti-technique-in-two-steps-case-report-and-literature-review
#10
J Acosta-León, A Pantoja-Rojas, J R Corona-Rivera, E López-Marure, C F Ploneda-Valencia
INTRODUCTION: Müllerian duct anomalies are rare with less than 200 cases published in the literature. Recently, the implementation of the Yang-Monti principle for the creation of the neovagina has been used in 10 previous published cases. Here, we report the first case of cervicovaginal agenesis treated with the modified Yang-Monti technique in two steps in México. PRESENTATION OF CASE: A 14-year-old female presented to the pediatric consult with a history of primary amenorrhea and a chronic-cyclic pelvic pain...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27897020/the-effect-of-erythropoietin-on-uterus-inflammation-during-ischemia-reperfusion-injury-in-rats
#11
C Tsompos, C Panoulis, K Toutouzas, A Triantafyllou, G Zografos, A Papalois
OBJECTIVE: This experiment evaluated the influence of erythropoietin (Epo) in an animal model of uterine ischemia reperfusion using the quoting established protocol. DESIGN: The effects of erythropoietin treatment were evaluated by mean uterus inflammation (UI) lesions. UI lesions were determined at the 60th reperfusion min (for groups A and C) and at the 120th reperfusion min (for groups B and D). Groups A and B received no drugs, whereas rats from groups C and D were administered with erythropoietin...
December 0: Ceská Gynekologie
https://www.readbyqxmd.com/read/27818250/a-novel-mechanism-of-non-feminizing-estrogens-in-neuroprotection
#12
Elizabeth B Engler-Chiurazzi, Douglas F Covey, James W Simpkins
Estrogens are potent and efficacious neuroprotectants both in vitro and in vivo in a variety of models of neurotoxicity. We determined the structural requirements for neuroprotection in an in vitro assay using a panel of >70 novel estratrienes, synthesized to reduce or eliminate estrogen receptor (ER) binding. We observed that neuroprotection could be enhanced by as much as 200-fold through modifications that positioned a large bulky group at the C2 or C4 position of the phenolic A ring of the estratriene...
August 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/27607535/which-donor-for-uterus-transplants-brain-dead-donor-or-living-donor-a-systematic-review
#13
REVIEW
Vincent Lavoué, Cécile Vigneau, Solène Duros, Karim Boudjema, Jean Levêque, Pascal Piver, Yves Aubard, Tristan Gauthier
BACKGROUND: The aim of this systematic review was to evaluate and compare the pros and cons of using living donors or brain-dead donors in uterus transplantation programs, 2 years after the first worldwide live birth after uterus transplantation. METHODS: The Medline database and the Central Cochrane Library were used to locate uterine transplantation studies carried out in human or nonhuman primates. All types of articles (case reports, original studies, meta-analyses, reviews) in English or French were considered for inclusion...
February 2017: Transplantation
https://www.readbyqxmd.com/read/27572931/interobserver-reliability-for-computed-tomography-findings-of-adnexal-torsion
#14
Megan H Lee, Nicholas Meyers, Constantine A Raptis, Vincent M Mellnick
Pelvic pain is a common presenting symptom in the emergency room, and prompt diagnosis of adnexal torsion is essential to reduce the risk of irreversible ovarian ischemia. Although ultrasound has been the study of choice for the diagnosis of adnexal torsion, patients with pelvic pain may often be imaged first with computed tomography given the prevalent use of computed tomography in the emergency department. Therefore, it is essential to be familiar with the computed tomography signs of adnexal torsion. A retrospective study of 40 patients with adnexal torsion with and without an adnexal mass was conducted to evaluate interobserver reliability for the computed tomography signs of adnexal torsion...
February 2017: Emergency Radiology
https://www.readbyqxmd.com/read/27347417/effect-of-hyperbaric-oxygen-on-lipid-peroxidation-and-visual-development-in-neonatal-rats-with-hypoxia-ischemia-brain-damage
#15
Jing Chen, Yan-Hui Chen, Hong-Yan Lv, Li-Ting Chen
The aim of the present study was to investigate the effect of hyperbaric oxygen (HBO) on lipid peroxidation and visual development in a neonatal rat model of hypoxic-ischemic brain damage (HIBD). The rat models of HIBD were established by delayed uterus dissection and were divided randomly into two groups (10 rats each): HIBD and HBO-treated HIBD (HIBD+HBO) group. Another 20 rats that underwent sham-surgery were also divided randomly into the HBO-treated and control groups. The rats that underwent HBO treatment received HBO (0...
July 2016: Biomedical Reports
https://www.readbyqxmd.com/read/27329637/evaluation-of-allowable-time-and-histopathological-changes-in-warm-ischemia-of-the-uterus-in-cynomolgus-monkey-as-a-model-for-uterus-transplantation
#16
Masataka Adachi, Iori Kisu, Toshihiro Nagai, Katsura Emoto, Kouji Banno, Kiyoko Umene, Yuya Nogami, Hideaki Tsuchiya, Iori Itagaki, Ikuo Kawamoto, Takahiro Nakagawa, Kazumasa Ogasawara, Daisuke Aoki
INTRODUCTION: The objective of this study was to examine the allowable warm ischemic time and pathological changes due to ischemia and reperfusion injury in the uterus of the cynomolgus monkey as a model for uterus transplantation. MATERIAL AND METHODS: Six female cynomolgus monkeys were used in the study. The uterus was resected from the vaginal canal and connected through the bilateral ovarian and uterine arteries and veins only. One animal was used as a control...
September 2016: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/27132411/complete-longitudinal-vaginal-septum-resection-description-of-a-bloodless-new-technique
#17
I Chatzipapas, D Zacharakis, L Michala, T Grigoriadis, P Antsaklis, A Protopapas
PURPOSE OF INVESTIGATION: To describe a novel approach for longitudinal vaginal septum (LVS) resection. Materials and Methods: Two cases of young girls with a uterus didelphys and a longitudinal vaginal septum. The technique consisted in grasping the vaginal septum with a laparoscopic 33-cm long bipolar cutting forceps, five-mm in diameter, and divided it to its midportion towards the two cervices. RESULTS: In both cases, the procedure was straightforward, uncomplicated, completed within three minutes and the patients were discharged four hours later...
2016: Clinical and Experimental Obstetrics & Gynecology
https://www.readbyqxmd.com/read/26978015/-the-mother-placenta-fetus-system-in-diffuse-toxic-goiter-morphopathological-aspects
#18
T V Pavlova, E S Malyutina, V A Petrukhin
OBJECTIVE: to compare the clinical and morphological parallels of the mother-placenta-fetus system in diffuse toxic goiter (DTG) through current morphological examinations. SUBJECTS AND METHODS: Sixty-five women whose pregnancy occurred with DTG were examined using both clinical and morphological studies (light, scanning electron, and atomic-force microscopies and macro- and microelement analysis); the placenta and uterus were investigated. RESULTS: Destructive changes and microrelief impairment, resulting from circulatory disorders (ischemia) and hemic hypoxia, were observed in the presence of DTG during pregnancy...
September 2015: Arkhiv Patologii
https://www.readbyqxmd.com/read/26941907/the-protective-effect-of-%C3%AE-aminobutyric-acid-on-kidney-injury-induced-by-renal-ischemia-reperfusion-in-ovariectomized-estradiol-treated-rats
#19
Nahid Talebi, Mehdi Nematbakhsh, Ramesh Monajemi, Safoora Mazaheri, Ardeshir Talebi, Marzieh Vafapour
BACKGROUND: Renal ischemia-reperfusion injury (IRI) is one of the most important causes of kidney injury, which is possibly gender-related. This study was designed to investigate the role of γ-aminobutyric acid (GABA) against IRI in ovariectomized estradiol-treated rats. METHODS: Thirty-five ovariectomized Wistar rats were used in six experimental groups. The first three groups did not subject to estradiol treatment and assigned as sham-operated, control, and GABA-treated groups...
2016: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/26887216/-from-biological-effects-of-local-cutaneous-thermal-stimulation-to-moxibustion-therapy
#20
REVIEW
Kai-yu Huang, Shuang Liang, Guang-yong Hu, Yang-yang Zou, Lu Lu, Jian-bin Zhang
Moxibustion is one of the major external therapies of traditional Chinese medicine (TCM) and exerts a definite favorable effect in the treatment of patients with different problems. In the present paper, the authors reviewed 38 papers about somatic thermal intervention therapy published in recent 15 years and analyzed its biological functions from local, distal, and whole body effects. The local effects include 1) improving cutaneous inflammatory illnesses as verruca, herpes simplex, Leishmania infection, cutaneous necrosis, wound disunion, and promoting percutaneous absorption of some medicines, swelling pain; 2) reliving sports fatigue and muscular injury, eliminating inflammation and pain reactions, probably by lowering local reactive oxygen species, superoxide dismutase,catalase, glutathione, etc...
December 2015: Zhen Ci Yan Jiu, Acupuncture Research
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