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https://www.readbyqxmd.com/read/29652725/therapeutic-strategies-involving-uterine-stem-cells-in-reproductive-medicine
#1
Michael Simoni, Hugh S Taylor
PURPOSE OF REVIEW: The current review provides an update on recent advances in stem cell biology relevant to female reproduction. RECENT FINDINGS: Stem cells are undifferentiated cells that often serve as a reservoir of cells to regenerate tissue in settings or injury or cell loss. The endometrium has progenitor stem cells that can replace all of the endometrium during each menstrual cycle. In addition, multipotent endometrial cells replace these progenitor cells when depleted...
April 12, 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29569955/placental-growth-factor-reverses-decreased-vascular-and-uteroplacental-mmp-2-and-9-and-increased-mmp-1-and-7-and-collagen-i-and-iv-in-hypertensive-pregnancy
#2
Zongli Ren, Ning Cui, Minglin Zhu, Raouf A Khalil
Preeclampsia is a complication of pregnancy manifested as maternal hypertension (HTN-Preg) and fetal growth restriction (IUGR), with unclear mechanism. Placental ischemia increases antiangiogenic soluble fms-like tyrosine-kinase-1 (sFlt-1) relative to angiogenic placental-growth-factor (PlGF); however, the molecular targets are unclear. To test the hypothesis that placental ischemia-induced changes in sFlt-1 and PlGF target vascular and uteroplacental matrix metalloproteinases (MMPs), we tested if raising sFlt-1/PlGF ratio by infusing sFlt-1 (10 µg/kg/day) in pregnant (Preg) rats increases blood pressure (BP) and alters MMPs, and if correcting sFlt-1/PlGF by infusing PlGF (20 µg/kg/day) in Preg rats with reduced uterine perfusion pressure (RUPP) improves BP and reverses the changes in MMPs...
March 23, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29475127/brief-hypoxic-cycles-improve-uterine-contractile-function-after-prolonged-hypoxia-in-term-pregnant-but-not-in-nonpregnant-rats-in-vitro
#3
Mohammed Alotaibi
During labour, the uterus itself is vulnerable to hypoxia/ischemia that can occur with each strong contraction and this may ultimately cause dysfunctional labour in some women. Periods of Intermittent re-oxygenations are beneficial to tissues subjected to hypoxia to wash out metabolic by-products that have been accumulated during hypoxic stresses which may affect the tissue viability. We proposed that short intermittent hypoxic episodes may protect the uterus from subsequent sustained long hypoxia. To investigate this, two sets of experiments were performed on term-pregnant and nonpregnant rat uterine tissues...
June 2018: Theriogenology
https://www.readbyqxmd.com/read/29416572/etiology-of-cesarean-uterine-scar-defect-niche-detailed-critical-analysis-of-hypotheses-and-prevention-strategies-and-peritoneal-closure-debate
#4
REVIEW
Shashikant L Sholapurkar
There is an increasing incidence of cesarean scar (CS) defect/niche and its sequelae, probably not entirely explained by better diagnosis or rising cesarean rate. Discussion of possible etiological factors has received scant attention but would be important to formulate preventive strategies. Meaningful informative studies on long-term sequelae of cesarean section are very difficult and none are available for causation of CS defect. Hence, it is crucial to identify key areas in etiology of CS defect for focused research...
March 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29385880/the-effect-of-antioxidants-on-angiogenesis-in-uterine-transplantation
#5
Tugba Ugurlu, Candan Ozogul, Gulistan Sanem Saribas, Seren Gulsen Gurgen, Seda Nur Akyol, Bahar Kartal
The aim of this study was to investigate the effect of antioxidants on angiogenesis in uterine transplantation. We used 24 female rats equally divided into four groups: Group 1 had the uterus stored in HTK (Histidine-Tryptophan-Ketoglutarate) solution at 4 °C cold storage for 4 h. Group 2 had the uterine tissue stored in HTK solution combined with acetyl L-carnitine (10-8  M) for 4 h at +4 °C. The same procedures with Group 1 and 2 were repeated for 24 h for Groups 3 and 4, respectively. Histological investigation and immunohistochemical analysis were performed...
April 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29376240/-impact-of-prostaglandin-f2%C3%AE-and-endothelin-pulsation-index-and-resistance-index-of-uterine-artery-blood-flow-on-dysmenorrhea-patients-of-cold-stagnation-and-blood-stasis-syndrome-with-dingkun-dan
#6
Kun Ma, Yan-Xia Chen, Yan-Ying Wang
This research apply Dingkun Dan to treat patients with dysmenorrhea of cold stagnation and blood stasis syndrome. This study observed its effectiveness and safety of the treatment of the disease and its influence on the serum prostaglandin F2α, endothefin, pulsatility index and resistant index of uterine artery blood, to explore the possible mechanism of effect of Dingkun Dan in the treatment of dysmenorrhea and provide scientific basis for clinical application. The 75 patients with dysmenorrhea of cold stagnation and blood stasis who met the inclusion criteria, were divided into treatment group (n=37) and control group (n=38) by using random number remainder grouping method...
December 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29364276/a-rat-model-of-mild-intrauterine-hypoperfusion-with-microcoil-stenosis
#7
Masahiro Tsuji, Jacques-Olivier Coq, Yuko Ogawa, Yumi Yamamoto, Makiko Ohshima
Intrauterine hypoperfusion/ischemia is one of the major causes of intrauterine/fetal growth restriction, preterm birth, and low birth weight. Most studies of this phenomenon have been performed in either models with severe intrauterine ischemia or models with gradient degree of intrauterine hypoperfusion. No study has been performed in a model on uniform mild intrauterine hypoperfusion (MIUH). Two models have been used for studies of MIUH: a model based on suture ligation of either side of the arterial arcade formed with the uterine and ovarian arteries, and a transient model based on clipping the bilateral ovarian arteries and aorta having patency...
January 7, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29077872/allowable-warm-ischemic-time-and-morphological-and-biochemical-changes-in-uterine-ischemia-reperfusion-injury-in-cynomolgus-macaque-a-basic-study-for-uterus-transplantation
#8
Iori Kisu, Kiyoko Umene, Masataka Adachi, Katsura Emoto, Yuya Nogami, Kouji Banno, Iori Itagaki, Ikuo Kawamoto, Takahiro Nakagawa, Hayato Narita, Atsushi Yoshida, Hideaki Tsuchiya, Kazumasa Ogasawara, Daisuke Aoki
No abstract text is available yet for this article.
December 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938750/allowable-warm-ischemic-time-and-morphological-and-biochemical-changes-in-uterine-ischemia-reperfusion-injury-in-cynomolgus-macaque-a-basic-study-for-uterus-transplantation
#9
Iori Kisu, Kiyoko Umene, Masataka Adachi, Katsura Emoto, Yuya Nogami, Kouji Banno, Iori Itagaki, Ikuo Kawamoto, Takahiro Nakagawa, Hayato Narita, Atsushi Yoshida, Hideaki Tsuchiya, Kazumasa Ogasawara, Daisuke Aoki
STUDY QUESTION: How long is the allowable warm ischemic time of the uterus and what morphological and biochemical changes are caused by uterine ischemia/reperfusion injury in cynomolgus macaques? SUMMARY ANSWER: Warm ischemia in the uterus of cynomolgus macaques is tolerated for up to 4 h and reperfusion after uterine ischemia caused no further morphological and biochemical changes. WHAT IS KNOWN ALREADY: Uterus transplantation is a potential option for women with uterine factor infertility...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28912068/angiogenic-imbalance-and-diminished-matrix-metalloproteinase-2-and-9-underlie-regional-decreases-in-uteroplacental-vascularization-and-feto-placental-growth-in-hypertensive-pregnancy
#10
Carlos A Dias-Junior, Juanjuan Chen, Ning Cui, Charles L Chiang, Minglin Zhu, Zongli Ren, Jose S Possomato-Vieira, Raouf A Khalil
Preeclampsia is a form of hypertension-in-pregnancy (HTN-Preg) with unclear mechanism. Generalized reduction of uterine perfusion pressure (RUPP) could be an initiating event leading to uteroplacental ischemia, angiogenic imbalance, and HTN-Preg. Additional regional differences in uteroplacental blood flow could further affect the pregnancy outcome and increase the risk of preeclampsia in twin or multiple pregnancy, but the mechanisms involved are unclear. To test the hypothesis that regional differences in angiogenic balance and matrix metalloproteinases (MMPs) underlie regional uteroplacental vascularization and feto-placental development, we compared fetal and placental growth, and placental and myoendometrial vascularization in the proximal, middle and distal regions of the uterus (in relation to the iliac bifurcation) in normal pregnant (Preg) and RUPP rats...
December 15, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28805600/the-effect-of-oxytocin-and-kisspeptin-10-in-ovary-and-uterus-of-ischemia-reperfusion-injured-rats
#11
M Aslan, G Erkanli Senturk, H Akkaya, S Sahin, B Yılmaz
OBJECTIVE: Ischemia/reperfusion (I/R) injuries result in damage to endothelial and parenchymal cells. Oxytocin (OXY) stimulates uterine contraction during parturition and myoepithelial cells during suckling. OXY has been used as a protective antioxidant. Kisspeptin plays a key role in the central control of reproductive functions and onset of puberty. Recent studies show that these reproductive hormones have protective potential as antioxidant. The aim of this study is to investigate the potential protective effects of Kisspeptin and OXY as antioxidants on I/R injured ovary and uterus of female rats...
August 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28626073/increased-vascular-and-uteroplacental-matrix-metalloproteinase-1-and-7-levels-and-collagen-type-i-deposition-in-hypertension-in-pregnancy-role-of-tnf-%C3%AE
#12
Wei Li, Ning Cui, Marc Q Mazzuca, Karina M Mata, Raouf A Khalil
Preeclampsia is a pregnancy-related disorder manifested as maternal hypertension in pregnancy (HTN-Preg) and fetal growth restriction. Placental ischemia could be an initiating event that leads to abnormal vascular and uteroplacental remodeling in HTN-Preg; however, the molecular targets and intermediary mechanisms involved are unclear. We tested the hypothesis that placental ischemia could target vascular and uteroplacental matrix metalloproteinases (MMPs) through an inflammatory cytokine-mediated mechanism...
September 1, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28624353/expression-of-hypoxia-inducible-factor-1%C3%AE-and-antioxidant-enzymes-superoxide-dismutases-1-and-2-in-ischemic-porcine-endometrium
#13
Joanna Kwiatkowska, Barbara Wąsowska, Przemysław Gilun
The aim of this study was to determine how 60-min ischemia changes the expression of hypoxia inducible factor 1α (HIF-1α) and superoxide dismutases (SOD)-1 and -2 in selected regions of porcine uterine horns. The results showed that 60-min ischemia of the porcine uterus conducted at the mid-secretory estrous phase caused decreased HIF-1α and increased SOD-2 gene expression. Higher expression of SOD-2 suggests that this enzyme may play an important role in the suppression of HIF-1α accumulation in an ischemic endometrium...
September 2017: Reproductive Biology
https://www.readbyqxmd.com/read/28535402/uterus-tolerance-to-extended-cold-ischemic-storage-after-auto-transplantation-in-ewes
#14
Jérémy Tricard, Sébastien Ponsonnard, Yannick Tholance, Laura Mesturoux, Denis Lachatre, Claude Couquet, Faraj Terro, Catherine Yardin, Pierre Marquet, Alessandro Piccardo, Tristan Gauthier
OBJECTIVE: To assess how the uterus tolerates extended cold ischemic storage before auto-transplantation in ewes. STUDY DESIGN: Fourteen uterine auto-transplantations were performed in ewes from November 2014 to June 2015 at the Analysis and Research Laboratory of Limoges, France. The animals were divided into 2 groups: 7 after 3h of cold ischemia timeand 7 after 24h. Transplant was assessed ≥8days after transplantation. Histology and apoptosis analyses (TUNEL method and indirect immunohistochemistry of cleaved Caspase 3) were performed before uterus retrieval (control), after 90min following reperfusion and ≥8days after transplantation...
July 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28506758/decreased-homodimerization-and-increased-timp-1-complexation-of-uteroplacental-and-uterine-arterial-matrix-metalloproteinase-9-during-hypertension-in-pregnancy
#15
Juanjuan Chen, Zongli Ren, Minglin Zhu, Raouf A Khalil
Preeclampsia is a complication of pregnancy manifested as hypertension-in-pregnancy (HTN-Preg) and often intrauterine growth restriction (IUGR). Placental ischemia could be an initiating event, but the molecular mechanisms are unclear. To test the hypothesis that dimerization of matrix metalloproteinases (MMPs) plays a role in HTN-Preg and IUGR, the levels/activity of MMP-9, tissue inhibitor of metalloproteinase (TIMP-1), and their dimerization forms were measured in the placenta, uterus, and uterine artery of normal pregnant (Preg) rats and a rat model of reduced uteroplacental perfusion pressure (RUPP)...
August 15, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28406930/eutopic-ectopic-endometrial-apoptosis-initiated-by-bilateral-uterine-artery-occlusion-a-new-therapeutic-mechanism-for-uterus-sparing-surgery-in-adenomyosis
#16
Li Chen, Caixia Li, Jing Guo, Ning Luo, Xiaoyan Qu, Le Kang, Mingmin Liu, Zhongping Cheng
The objective of the present study was to investigate differences in the expression of apoptosis-related factors in the eutopic and ectopic endometrium (EuE/EE) in women with adenomyosis before and after laparoscopic bilateral uterine artery occlusion (LUAO). Ten patients with uterine adenomyosis who received LUAO were selected as the research subjects, from whom EuE and EE tissues were obtained before and after LUAO and detected for the expression of apoptosis-related molecules in EuE and EE by PT-PCR and Western blot, and changes in the mitochondrial structure by electron microscopy...
2017: PloS One
https://www.readbyqxmd.com/read/28376665/thinking-outside-the-box
#17
REVIEW
Judith Ingles, Chandrashekara N Kyathanahalli, Pancharatnam Jeyasuria, Jennifer C Condon
A broad definition of preconditioning is "the preparation for a subsequent action." Mounting evidence demonstrates that novel remote preconditioning paradigms, in which protective stimuli experienced locally can capacitate systemic tolerance and enhanced cell viability upon exposure to ensuing cellular insults, have been largely successful in the field of cardiovascular ischemia/reperfusion injury. To ensure successful protective preconditioning, some models (including the uterus) have been demonstrated to activate the unfolded protein response (UPR), which is a cellular stress response controlled at the level of the endoplasmic reticulum...
July 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28273748/the-effects-of-uterine-artery-embolization-with-a-new-degradable-microsphere-in-an-experimental-study
#18
Johan Bengtsson, Wojciech Cwikiel, Pia C Sundgren, Erika Karlstam, Dolores Gavier-Widén, Inger Keussen
Background Transarterial particle embolization is a common treatment of uterine fibroids, aiming to obtain ischemia resulting in shrinking of the fibroid with preservation of normal uterine tissue. Embolization with non-degradable microspheres is established, but causes permanent occlusion of the arteries, affecting both the uterus as well as the fibroids. Purpose To evaluate in vivo degradation, local tissue effects, and possible recanalization following intra-arterial deposition of the new, degradable starch microspheres (DSM), in a short-term experimental pilot study...
November 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28236104/uterine-fibroid-therapy-using-interventional-radiology-mini-invasive-treatments-current-perspective
#19
REVIEW
Carlo Masciocchi, Francesco Arrigoni, Fabiana Ferrari, Aldo Victor Giordano, Sonia Iafrate, Ilaria Capretti, Ester Cannizzaro, Alfonso Reginelli, Anna Maria Ierardi, Chiara Floridi, Alessio Salvatore Angileri, Luca Brunese, Antonio Barile
Uterine fibroids are common benign tumors of unclear etiopathology that affect the female reproductive tract. They are responsible for considerable morbidity and deterioration of life quality, and may have a negative impact on the reproductive system as well. Besides surgery aided by uterus-saving techniques, several minimally invasive procedures are now available within the field of interventional radiology that represent a valid solution for women who desire pregnancy and relief from disease-specific symptomatology...
April 2017: Medical Oncology
https://www.readbyqxmd.com/read/28157642/cervicovaginal-agenesis-treated-with-modified-yang-monti-technique-in-two-steps-case-report-and-literature-review
#20
J Acosta-León, A Pantoja-Rojas, J R Corona-Rivera, E López-Marure, C F Ploneda-Valencia
INTRODUCTION: Müllerian duct anomalies are rare with less than 200 cases published in the literature. Recently, the implementation of the Yang-Monti principle for the creation of the neovagina has been used in 10 previous published cases. Here, we report the first case of cervicovaginal agenesis treated with the modified Yang-Monti technique in two steps in México. PRESENTATION OF CASE: A 14-year-old female presented to the pediatric consult with a history of primary amenorrhea and a chronic-cyclic pelvic pain...
2017: International Journal of Surgery Case Reports
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