Julie Favre, Ji Gao, Jean-Paul Henry, Isabelle Remy-Jouet, Isabelle Fourquaux, Audrey Billon-Gales, Christian Thuillez, Jean-François Arnal, Françoise Lenfant, Vincent Richard
OBJECTIVE: To assess the coronary endothelial protective effects of 17β-estradiol (E2) and the role of estrogen receptor (ER) α in ischemia/reperfusion (I/R). METHODS AND RESULTS: E2 exerts protective effects in cardiac I/R. However, the implication in vivo of the endothelium and the cellular targets of the anti-ischemic effects of E2 are unknown. Mice were subjected to I/R (30 minutes of I and 1 hour of R) in vivo, after which acetylcholine-induced relaxation of isolated coronary segments was assessed ex vivo...
December 2010: Arteriosclerosis, Thrombosis, and Vascular Biology