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Uterine transplantation

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https://www.readbyqxmd.com/read/29687472/conscience-claims-metaphysics-and-avoiding-an-lgbt-eugenic
#1
Abram Brummett
Novel assisted reproductive technologies (ART) are poised to present our society with strange new ethical questions, such as whether lesbian, gay, bisexual, and transgender (LGBT) couples should be allowed to produce children biologically related to both parents, or whether trans-women who want to experience childbirth should be allowed to receive uterine transplants. Clinicians opposed to offering such technologies to LGBT couples on moral grounds are likely to seek legal shelter through the conscience clauses enshrined in U...
April 23, 2018: Bioethics
https://www.readbyqxmd.com/read/29682321/use-of-biomedical-photonics-in-gynecological-surgery-a-uterine-transplantation-model
#2
Srdjan Saso, Neil T Clancy, Benjamin P Jones, Timothy Bracewell-Milnes, Maya Al-Memar, Eleanor M Cannon, Simran Ahluwalia, Joseph Yazbek, Meen-Yau Thum, Tom Bourne, Daniel S Elson, James Richard Smith, Sadaf Ghaem-Maghami
Aim: Uterine transplantation (UTx) has been proposed as a treatment for permanent absolute uterine factor infertility. The study aims were to compare pulse oximetry and multispectral imaging (MSI), for intraoperative tracking of uterine oxygen saturation in animal UTx models (rabbit and sheep). Results/methodology: Imaging results confirmed the re-establishment of adequate perfusion in the transplanted organ after surgery. Comparison of oxygen saturation   values between the pre-UTx donor and post-UTx recipient, and pre-UTx and post-UTx recipient reveals a statistically significant decrease in saturation levels post-UTx...
April 2018: Future Science OA
https://www.readbyqxmd.com/read/29679753/daidzein-rich-isoflavone-aglycones-inhibit-cell-growth-and-inflammation-in-endometriosis
#3
O Takaoka, T Mori, F Ito, H Okimura, H Kataoka, Y Tanaka, A Koshiba, I Kusuki, S Shigehiro, T Amami, J Kitawaki
Endometriosis is an estrogen-dependent disease, and isoflavones interact with estrogen receptors. The purposes of this study are to investigate the in vitro and in vivo effects of daidzein-rich isoflavone aglycones (DRIAs), dietary supplements, on cellular proliferation in endometriosis. Stromal cells isolated from ovarian endometrioma (OESCs) and normal endometrium (NESCs) were cultured with DRIAs, i.e., each of the DRIA components (daidzein, genistein, or glycitein), or isoflavone glycosides (IG; DRIA precursors)...
April 18, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29621960/experimental-uterus-transplant-in-various-models-review-of-surgical-techniques
#4
Jalal Arvin, Maryam Ashrafi, Saeedeh Lotfi, Arash Dadvand Meshgin Shahr, Elvira Schomann, Kristina Scheerer, Elke Schulmeyer
Uterus transplantation may become the surgical therapeutic modality of choice for uterine factor infertility. However, this procedure still faces technical, therapeutic, and immunologic challenges that limit its success and clinical application. Experimental studies are therefore still needed to address various challenges in the field of uterus transplantation. Among various laboratory animals, small animals are ideal models for the purpose of experimental uterus transplant. However, clinical success in small animal models is not generalizable to clinical application and treatment for uterine factor infertility in humans...
April 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29576000/uterine-autotransplantation-in-the-nonhuman-primate-with-preservation-of-the-uterine-and-ovarian-vascular-pedicles
#5
Michelle N Han, Hugo Ramirez, Luis Ruvalcaba, Juan Luis Contreras, Atunga Nyachieo, Edwin Ramirez
PURPOSE: To evaluate the technical feasibility of performing a uterine autotransplantation in the nonhuman primate while preserving the uterine and ovarian vascular pedicles. METHODS: Eight (n = 8) female baboons at a primate research facility underwent a uterine autotransplant procedure with preservation of the vascular pedicles. The uterine arteries were separated from their amorphous tissue and skeletonized toward the internal iliac arteries bilaterally. A segment of the internal iliac artery was removed bilaterally along with both uterine arteries...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29575738/first-live-birth-after-uterus-transplantation-in-the-united-states
#6
G Testa, G J McKenna, R T Gunby, T Anthony, E C Koon, A M Warren, J M Putman, L Zhang, G dePrisco, J M Mitchell, K Wallis, G B Klintmalm, M Olausson, L Johannesson
Uterus transplantation has proven to be a successful treatment for women with absolute uterine infertility, caused either by the absence of a uterus or the presence of a nonfunctioning uterus. We report the first birth of a healthy child following uterus transplantation in the United States, from a recipient of a uterus allograft procured from an altruistic living donor. Two major modifications from the previously reported live births characterized this uterus transplant. First, the transplanted uterus relied upon and sustained the pregnancy while having only the utero-ovarian vein as venous outflow...
March 25, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29574054/uterine-transplantation-review-in-human-research
#7
REVIEW
A Favre-Inhofer, A Rafii, M Carbonnel, A Revaux, J M Ayoubi
Uterine transplantation is the solution to treat absolute uterine fertility. In this review, we present the historical, medical, technical, psychological and ethical perspectives in human uterine transplantation research. We reviewed the PubMed database following PRISMA guidelines and added data presented by several research teams during the first international congress on uterine transplantation.
March 21, 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29571018/stem-cell-therapy-in-asherman-syndrome-and-thin-endometrium-stem-cell-based-therapy
#8
REVIEW
Ramyar Azizi, Leili Aghebati-Maleki, Mohammad Nouri, Faroogh Marofi, Sohrab Negargar, Mehdi Yousefi
The endometrium is one of the essential components of the uterus. The endometrium of human is a complex and dynamic tissue, which undergoes periods of growth and turn over during any menstrual cycle. Stem cells are initially undifferentiated cells that display a wide range of differentiation potential with no distinct morphological features. Stem cell therapy method recently has become a novel procedure for treatment of tissue injury and fibrosis in response to damage. Currently, there is massive interest in stem cells as a novel treatment method for regenerative medicine and more specifically for the regeneration of human endometrium disorder like Asherman syndrome (AS) and thin endometrium...
March 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29524724/a-survey-of-public-opinion-in-the-united-states-regarding-uterine-transplantation
#9
Eduardo Hariton, Pietro Bortoletto, Randi H Goldman, Leslie V Farland, Elizabeth S Ginsburg, Antonio R Gargiulo
OBJECTIVE: Our objective was to evaluate opinions and attitudes of the general public regarding uterine transplantation (UTx) in the United States (U.S.). DESIGN: Cross-sectional study (Canadian Task Force Classification II-2) SETTING: Web-based survey. PATIENTS(S): Nationally representative sample of adult U.S. residents by age and gender. INTERVENTION(S): Web-based questionnaire administered in November 2016. MAIN OUTCOME MEASURE(S): Respondents who supported UTx were compared with those who were opposed using log binomial regression to calculate relative risk ratios and 95% confidence intervals RESULT(S): Of the 1,444 respondents recruited, 1,337 (93%) completed the survey...
March 7, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29506220/identification-of-trophectoderm-derived-cripto-as-an-essential-mediator-of-embryo-implantation
#10
Eran Gershon, Ron Hadas, Michal Elbaz, Evan Booker, Moran Muchnik, Alona Kleinjan, Sharon Karasenti, Olga Genin, Yuval Cinnamon, Peter C Gray
Cripto-1 (TDGF1) is a multifunctional signaling factor that stimulates cellular effects including proliferation, migration, survival, EMT and angiogenesis to regulate embryogenesis, tissue homeostasis and tumorigenesis. Those cell behaviors are also associated with implantation of the embryo into the uterine wall and this led us to investigate the role of embryo-derived Cripto in embryo attachment and implantation. We show here that Cripto and its signaling mediator GRP78 are uniquely localized to embryo implantation sites...
February 28, 2018: Endocrinology
https://www.readbyqxmd.com/read/29501812/uterine-transplantation-a-survey-of-perceptions-and-attitudes-of-american-reproductive-endocrinologists-and-gynecologic-surgeons
#11
Pietro Bortoletto, Eduardo Hariton, Leslie V Farland, Randi H Goldman, Antonio R Gargiulo
OBJECTIVE: To determine whether reproductive endocrinologists and minimally invasive surgeons support uterine transplantation as a treatment option for absolute uterine factor infertility (AUFI). DESIGN: Cross-sectional study (Canadian Task Force Classification II-2) SETTING: Web-based survey. PATIENTS(S): Physician members of the American Society of Reproductive Medicine (ASRM) and the American Association of Gynecologic Laparoscopists (AAGL)...
March 1, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29501707/uterine-transplantation-minimally-invasive-approach
#12
EDITORIAL
Rebecca L Flyckt, Ruth M Farrell, Tommaso Falcone
No abstract text is available yet for this article.
February 28, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29434492/sr-16234-a-novel-selective-estrogen-receptor-modulator-for-pain-symptoms-with-endometriosis-an-open-label-clinical-trial
#13
Tasuku Harada, Ikuko Ohta, Yusuke Endo, Hiroshi Sunada, Hisashi Noma, Fuminori Taniguchi
Background: SR-16234 is a selective estrogen receptor modulator (SERM) structurally different from approved SERM and has been reported to have estrogen receptor (ER) α antagonistic activity and strong affinity with a weak partial agonistic activity to ERβ receptor. SR-16234 showed strong inhibitory effects on transplanted endometrial cysts in the endometriosis model of rat and mouse. In this clinical trial, efficacy and safety of SR-16234 have been evaluated in endometriosis patients...
December 2017: Yonago Acta Medica
https://www.readbyqxmd.com/read/29433563/therapeutic-effect-of-human-umbilical-cord-derived-mesenchymal-stem-cells-on-injured-rat-endometrium-during-its-chronic-phase
#14
Lu Zhang, Ying Li, Chun-Yi Guan, Shi Tian, Xiao-Dan Lv, Jian-Hui Li, Xu Ma, Hong-Fei Xia
BACKGROUND: Repair deficiency after endometrial injury is an important reason for intra-uterine adhesions, amenorrhea, and infertility in females. Bone marrow-derived mesenchymal stem cell (BMSC) transplantation is effective in repairing the damaged endometrium. However, the possibility of using umbilical cord-derived MSCs (UC-MSCs) to treat endometrial injury is rarely reported. METHODS: Ethanol (95%) was injected into rat uterus to establish a model of endometrial injury...
February 13, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29423621/uterine-transplant-a-risk-to-life-or-a-chance-for-life
#15
Alankrita Taneja, Siddhartha Das, Syed Ather Hussain, Mohammed Madadin, Stany Wilfred Lobo, Huda Fatima, Ritesh G Menezes
Being inherently different from any other lifesaving organ transplant, uterine transplantation does not aim at saving lives but supporting the possibility to generate life. Unlike the kidneys or the liver, the uterus is not specifically a vital organ. Given the non-lifesaving nature of this procedure, questions have been raised about its feasibility. The ethical dilemma revolves around whether it is worth placing two lives at risk related to surgery and immunosuppression, amongst others, to enable a woman with absolute uterine factor infertility to experience the presence of an organ enabling childbirth...
February 8, 2018: Science and Engineering Ethics
https://www.readbyqxmd.com/read/29423555/second-malignancies-after-hematopoietic-stem-cell-transplantation
#16
REVIEW
Ivetta Danylesko, Avichai Shimoni
Second malignancies are a rare but well-defined late complication after autologous and allogeneic hematopoietic stem-cell transplantation (SCT). Solid malignancies occur in up to 15% of patients 15 years after SCT with myeloablative conditioning, with no plateau in the incidence rates. They are responsible for 5-10% of late deaths after SCT. The incidence is increased with advanced age at SCT. The major risk factors are the use of total body irradiation, which is associated with adenocarcinomas and with chronic graft-versus-host disease which is associated with squamous cell cancers...
February 8, 2018: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29385880/the-effect-of-antioxidants-on-angiogenesis-in-uterine-transplantation
#17
Tugba Ugurlu, Candan Ozogul, Gulistan Sanem Saribas, Seren Gulsen Gurgen, Seda Nur Akyol, Bahar Kartal
The aim of this study was to investigate the effect of antioxidants on angiogenesis in uterine transplantation. We used 24 female rats equally divided into four groups: Group 1 had the uterus stored in HTK (Histidine-Tryptophan-Ketoglutarate) solution at 4 °C cold storage for 4 h. Group 2 had the uterine tissue stored in HTK solution combined with acetyl L-carnitine (10-8  M) for 4 h at +4 °C. The same procedures with Group 1 and 2 were repeated for 24 h for Groups 3 and 4, respectively. Histological investigation and immunohistochemical analysis were performed...
April 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29379666/could-the-female-to-male-transgender-population-be-donor-candidates-for-uterus-transplantation
#18
Murat Api, Ayşen Boza, Mehmet Ceyhan
Objective: To evaluate the eligibility of female-to-male (FtM) transgender people as donor candidates with regard to histologic, surgical, and social aspects. Materials and Methods: In this prospective cohort study, 31 FtM transgender people underwent standard hysterectomy and bilateral salpingo-oophorectomy for gender reassignment upon their request. The pelvic viscera of the transgender people was intraoperatively observed and the histology of the removed uteri were evaluated for fertility capacity and procurement surgery...
December 2017: Turkish journal of obstetrics and gynecology
https://www.readbyqxmd.com/read/29366966/laparoscopic-assisted-uterus-retrieval-from-live-organ-donors-for-uterine-transplant-our-experience-of-two-patients
#19
Shailesh Puntambekar, Milind Telang, Pankaj Kulkarni, Seema Puntambekar, Sanjeev Jadhav, Mangesh Panse, Ravindra Sathe, Nikhil Agarkhedkar, Neeta Warty, Sandesh Kade, Manoj Manchekar, Hirav Parekh, Kajal Parikh, Riddhi Desai, Mehul Mehta, Mihir Chitale, Bhushan Kinholkar, Joy Shankar Jana, Avinash Pare, Abhay Sadre, Swapnil Karnik, Abhay Mane, Giriraj Gandhi, Shailendra Kanade, Uday Phadke
STUDY OBJECTIVE: To report the first ever laparoscopic-assisted live donor uterus retrieval in 2 patients for uterus transplant. DESIGN: Case study (Canadian Task Force classification III). SETTING: Galaxy CARE Laparoscopy Institute, Pune, India. PATIENTS: Two patients with absolute uterine factor infertility with their mothers as donors. INTERVENTIONS: In vitro fertilization and uterine transplant...
January 31, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29300901/aromatase-inhibitor-use-during-ovarian-stimulation-suppresses-growth-of-uterine-endometrial-cancer-in-xenograft-mouse-model
#20
Tai Kawahara, Naoki Okamoto, Seido Takae, Megumi Kashiwagi, Mariko Nakajima, Atsushi Uekawa, Junya Ito, Naomi Kashiwazaki, Yodo Sugishita, Nao Suzuki
STUDY QUESTION: Could aromatase inhibitors (AI) be used to reduce risks of uterine endometrial cancer growth or recurrence during ovarian stimulation? SUMMARY ANSWER: In a xenograft mouse model of endometrial cancer, concomitant AI administration suppressed the growth of endometrial cancer during ovarian stimulation. WHAT IS KNOWN ALREADY: Recurrence and mortality rates of estrogen receptor-positive early breast cancer are reduced by long-term AI administration...
February 1, 2018: Human Reproduction
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