keyword
MENU ▼
Read by QxMD icon Read
search

Uterine transplantation

keyword
https://www.readbyqxmd.com/read/29891843/establishment-of-a-novel-mouse-xenograft-model-of-human-uterine-leiomyoma
#1
Yusuke Suzuki, Masaaki Ii, Takashi Saito, Yoshito Terai, Yasuhiko Tabata, Masahide Ohmichi, Michio Asahi
Uterine leiomyoma is the most common benign tumour in women, and an appropriate animal model for leiomyoma would be useful for exploring new therapeutic strategies. Therefore, we have been challenged to develop a new simple mouse model for human leiomyoma. Leiomyoma tissues were harvested from myomas resected by different surgical procedures with or without gonadotropin-releasing hormone agonist (GnRHa) treatment and were subcutaneously implanted into BALB/c nude mice with an estradiol/progesterone-releasing pellet...
June 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29851156/possible-impact-of-immunosuppressive-therapy-regimens-on-histopathologic-outcomes-of-abnormal-uterine-bleeding-in-solid-organ-transplant-recipients
#2
Yusuf Aytaç Tohma, Hüseyin Akıllı, Mahir Kırnap, Asuman Nihan Haberal, Dilan Akyel, Hatice Yağmur Zengin, Hulusi Bülent Zeyneloğlu, Esra Kuşçu, Ali Ayhan, Mehmet Haberal
BACKGROUND: In this study, we aimed to determine the frequency of histopathologic outcomes of solid-organ transplantation in women with abnormal uterine bleeding (AUB) receiving immunosupressive therapies. METHODS: This is a retrospective study including a single-center experience. Data were extracted from hospital records, and solid-organ transplant recipients who were diagnosed with AUB were included. RESULTS: Fifty-five of these patients were renal transplant recipients (79...
May 31, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29781949/optn-vascularized-composite-allograft-vca-waiting-list-current-status-and-trends-in-the-united-states
#3
Jennifer L Wainright, Christopher L Wholley, Wida S Cherikh, Jennifer M Musick, David K Klassen
BACKGROUND: Vascularized Composite Allograft (VCA) transplantation is a developing area in the field of transplantation. METHODS: This study used Organ Procurement and Transplantation Network (OPTN) VCA waiting list and transplant data from July 3, 2014 through February 28, 2018 to characterize the OPTN VCA waiting list in terms of composition, removal patterns, waiting time, resulting transplants, and trends over time. RESULTS: Between implementation of the OPTN VCA waiting list on July 3, 2014 and February 28, 2018, 54 candidates - 53...
April 30, 2018: Transplantation
https://www.readbyqxmd.com/read/29765518/increasing-aggressiveness-of-patient-derived-xenograft-models-of-cervix-carcinoma-during-serial-transplantation
#4
Catherine S Wegner, Anette Hauge, Lise Mari K Andersen, Ruixia Huang, Trude G Simonsen, Jon-Vidar Gaustad, Einar K Rofstad
Four patient-derived xenograft (PDX) models (BK-12, ED-15, HL-16, LA-19) of carcinoma of the uterine cervix have been developed in our laboratory, and their stability during serial transplantation in vivo was investigated in this study. Two frozen cell stocks were established, one from xenografted tumors in passage 2 (early generation) and the other from xenografted tumors transplanted serially in mice for approximately two years (late generation), and the biology of late generation tumors was compared with that of early generation tumors...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29751094/the-interest-of-women-with-mayer-rokitansky-k%C3%A3-ster-hauser-syndrome-and-laparoscopic-vecchietti-neovagina-in-uterus-transplantation
#5
Roman Chmel, Marta Novackova, Zlatko Pastor, Jiri Fronek
STUDY OBJECTIVE: The goal of this study was to assess a group of Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) women with surgically created neovaginas in the interest of uterus transplantation (UTx) and to recruit the first group of applicants for a uterus transplant trial. DESIGN: and Setting: This is an original prospective study using semistructured interviews. PARTICIPANTS: A study group of 50 MRKH syndrome women with Vecchietti neovaginas was recruited by letter of invitation...
May 8, 2018: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29747272/-analysis-of-proliferative-lesions-of-haematopoietic-and-lymphoid-tissue-in-the-female-productive-tract
#6
D B Chen, H Zhang, Y H Zhang, Y Wang, Q J Song, S M Yang, H Cui, Y Zhao, X Z Fang, D H Shen
Objective: To study the clinicopathologic features, diagnosis and differential diagnosis of tumors of haematopoietic and lymphoid tissue in the female productive tract. Methods: Eleven cases of myeloid sarcoma and leukemia, 9 of non Hodgkin lymphoma (NHL) , 13 of cervical lymphoma-like lesions were selected from Peking University People's Hospital from January 2006 to August 2017. According to WHO classification of tumors of haematopoietic and lymphoid tissues (2008) and updated classification(2016), the cases were studied by microscopy, immunohistochemistry and in situ hybridization...
April 25, 2018: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29734842/the-beneficial-effects-of-nerolidol-and-hesperidin-on-surgically-induced-endometriosis-in-a-rat-model
#7
Rauf Melekoglu, Osman Ciftci, Sevil Eraslan, Aslı Cetin, Nese Basak
The objective of this article is to analyze the effects of nerolidol and hesperidin treatment on surgically induced endometriosis in a rat model. Endometriosis was induced in 24 healthy adult female Wistar albino rats via homologous uterine horn transplantation. Three operations were performed on each rat. After the second operation, the rats were randomized into control, nerolidol, and hesperidin treatment groups, and medications were administered for 2 weeks. The effects of the drugs on the endometriotic foci were evaluated after the third operation...
May 7, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29701160/non-pregnant-human-uterus-as-source-of-mesenchymal-stem-cells
#8
Noemi Eiro, Maria Fraile, Jose Schneider, Francisco Vizoso
Stem/progenitor cells for cell therapy and regenerative medicine should ideally be available in large numbers, after having been isolated using minimally invasive or non-invasive methodologies. Also, they should exhibit wide differentiation potential into multiple lineages, as well as capability to be used successfully in autologous or allogeneic transplantation, and all this in accordance with the applicable guidelines of good manufacturing practice. Thus, the identification and characterization of alternative sources of mesenchymal stem cells (MSCs) is of great importance...
April 26, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29687472/conscience-claims-metaphysics-and-avoiding-an-lgbt-eugenic
#9
Abram Brummett
Novel assisted reproductive technologies (ART) are poised to present our society with strange new ethical questions, such as whether lesbian, gay, bisexual, and transgender (LGBT) couples should be allowed to produce children biologically related to both parents, or whether trans-women who want to experience childbirth should be allowed to receive uterine transplants. Clinicians opposed to offering such technologies to LGBT couples on moral grounds are likely to seek legal shelter through the conscience clauses enshrined in U...
June 2018: Bioethics
https://www.readbyqxmd.com/read/29682321/use-of-biomedical-photonics-in-gynecological-surgery-a-uterine-transplantation-model
#10
Srdjan Saso, Neil T Clancy, Benjamin P Jones, Timothy Bracewell-Milnes, Maya Al-Memar, Eleanor M Cannon, Simran Ahluwalia, Joseph Yazbek, Meen-Yau Thum, Tom Bourne, Daniel S Elson, James Richard Smith, Sadaf Ghaem-Maghami
Aim: Uterine transplantation (UTx) has been proposed as a treatment for permanent absolute uterine factor infertility. The study aims were to compare pulse oximetry and multispectral imaging (MSI), for intraoperative tracking of uterine oxygen saturation in animal UTx models (rabbit and sheep). Results/methodology: Imaging results confirmed the re-establishment of adequate perfusion in the transplanted organ after surgery. Comparison of oxygen saturation   values between the pre-UTx donor and post-UTx recipient, and pre-UTx and post-UTx recipient reveals a statistically significant decrease in saturation levels post-UTx...
April 2018: Future Science OA
https://www.readbyqxmd.com/read/29679753/daidzein-rich-isoflavone-aglycones-inhibit-cell-growth-and-inflammation-in-endometriosis
#11
O Takaoka, T Mori, F Ito, H Okimura, H Kataoka, Y Tanaka, A Koshiba, I Kusuki, S Shigehiro, T Amami, J Kitawaki
Endometriosis is an estrogen-dependent disease, and isoflavones interact with estrogen receptors. The purposes of this study are to investigate the in vitro and in vivo effects of daidzein-rich isoflavone aglycones (DRIAs), dietary supplements, on cellular proliferation in endometriosis. Stromal cells isolated from ovarian endometrioma (OESCs) and normal endometrium (NESCs) were cultured with DRIAs, i.e., each of the DRIA components (daidzein, genistein, or glycitein), or isoflavone glycosides (IG; DRIA precursors)...
July 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29621960/experimental-uterus-transplant-in-various-models-review-of-surgical-techniques
#12
Jalal Arvin, Maryam Ashrafi, Saeedeh Lotfi, Arash Dadvand Meshgin Shahr, Elvira Schomann, Kristina Scheerer, Elke Schulmeyer
Uterus transplantation may become the surgical therapeutic modality of choice for uterine factor infertility. However, this procedure still faces technical, therapeutic, and immunologic challenges that limit its success and clinical application. Experimental studies are therefore still needed to address various challenges in the field of uterus transplantation. Among various laboratory animals, small animals are ideal models for the purpose of experimental uterus transplant. However, clinical success in small animal models is not generalizable to clinical application and treatment for uterine factor infertility in humans...
April 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29576000/uterine-autotransplantation-in-the-nonhuman-primate-with-preservation-of-the-uterine-and-ovarian-vascular-pedicles
#13
Michelle N Han, Hugo Ramirez, Luis Ruvalcaba, Juan Luis Contreras, Atunga Nyachieo, Edwin Ramirez
PURPOSE: To evaluate the technical feasibility of performing a uterine autotransplantation in the nonhuman primate while preserving the uterine and ovarian vascular pedicles. METHODS: Eight (n = 8) female baboons at a primate research facility underwent a uterine autotransplant procedure with preservation of the vascular pedicles. The uterine arteries were separated from their amorphous tissue and skeletonized toward the internal iliac arteries bilaterally. A segment of the internal iliac artery was removed bilaterally along with both uterine arteries...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29575738/first-live-birth-after-uterus-transplantation-in-the-united-states
#14
G Testa, G J McKenna, R T Gunby, T Anthony, E C Koon, A M Warren, J M Putman, L Zhang, G dePrisco, J M Mitchell, K Wallis, G B Klintmalm, M Olausson, L Johannesson
Uterus transplantation has proven to be a successful treatment for women with absolute uterine infertility, caused either by the absence of a uterus or the presence of a nonfunctioning uterus. We report the first birth of a healthy child following uterus transplantation in the United States, from a recipient of a uterus allograft procured from an altruistic living donor. Two major modifications from the previously reported live births characterized this uterus transplant. First, the transplanted uterus relied upon and sustained the pregnancy while having only the utero-ovarian vein as venous outflow...
May 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29574054/uterine-transplantation-review-in-human-research
#15
REVIEW
A Favre-Inhofer, A Rafii, M Carbonnel, A Revaux, J M Ayoubi
Uterine transplantation is the solution to treat absolute uterine fertility. In this review, we present the historical, medical, technical, psychological and ethical perspectives in human uterine transplantation research. We reviewed the PubMed database following PRISMA guidelines and added data presented by several research teams during the first international congress on uterine transplantation.
March 21, 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29571018/stem-cell-therapy-in-asherman-syndrome-and-thin-endometrium-stem-cell-based-therapy
#16
REVIEW
Ramyar Azizi, Leili Aghebati-Maleki, Mohammad Nouri, Faroogh Marofi, Sohrab Negargar, Mehdi Yousefi
The endometrium is one of the essential components of the uterus. The endometrium of human is a complex and dynamic tissue, which undergoes periods of growth and turn over during any menstrual cycle. Stem cells are initially undifferentiated cells that display a wide range of differentiation potential with no distinct morphological features. Stem cell therapy method recently has become a novel procedure for treatment of tissue injury and fibrosis in response to damage. Currently, there is massive interest in stem cells as a novel treatment method for regenerative medicine and more specifically for the regeneration of human endometrium disorder like Asherman syndrome (AS) and thin endometrium...
June 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29524724/a-survey-of-public-opinion-in-the-united-states-regarding-uterine-transplantation
#17
Eduardo Hariton, Pietro Bortoletto, Randi H Goldman, Leslie V Farland, Elizabeth S Ginsburg, Antonio R Gargiulo
STUDY OBJECTIVE: To evaluate the opinions and attitudes of the general public regarding uterine transplantation (UTx) in the United States. DESIGN: A cross-sectional study (Canadian Task Force classification II-2). SETTING: A Web-based survey. PATIENTS: A nationally representative sample of adult US residents by age and sex. INTERVENTIONS: A Web-based questionnaire administered in November 2016...
March 7, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29506220/identification-of-trophectoderm-derived-cripto-as-an-essential-mediator-of-embryo-implantation
#18
Eran Gershon, Ron Hadas, Michal Elbaz, Evan Booker, Moran Muchnik, Alona Kleinjan-Elazary, Sharon Karasenti, Olga Genin, Yuval Cinnamon, Peter C Gray
Cripto-1 (TDGF1) is a multifunctional signaling factor that stimulates cellular effects, including proliferation, migration, survival, epithelial-to-mesenchymal transition, and angiogenesis, to regulate embryogenesis, tissue homeostasis, and tumorigenesis. Those cell behaviors are also associated with implantation of the embryo into the uterine wall, and this led us to investigate the role of embryo-derived Cripto in embryo attachment and implantation. In this study, we show that Cripto and its signaling mediator GRP78 are uniquely localized to embryo implantation sites...
April 1, 2018: Endocrinology
https://www.readbyqxmd.com/read/29501812/uterine-transplantation-a-survey-of-perceptions-and-attitudes-of-american-reproductive-endocrinologists-and-gynecologic-surgeons
#19
Pietro Bortoletto, Eduardo Hariton, Leslie V Farland, Randi H Goldman, Antonio R Gargiulo
OBJECTIVE: To determine whether reproductive endocrinologists and minimally invasive surgeons support uterine transplantation as a treatment option for absolute uterine factor infertility (AUFI). DESIGN: A cross-sectional study (Canadian Task Force classification II-2). SETTING: A Web-based survey. PATIENTS: Physician members of the American Society of Reproductive Medicine (ASRM) and the American Association of Gynecologic Laparoscopists (AAGL)...
March 2, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29501707/uterine-transplantation-a-minimally-invasive-approach
#20
EDITORIAL
Rebecca L Flyckt, Ruth M Farrell, Tommaso Falcone
No abstract text is available yet for this article.
May 2018: Journal of Minimally Invasive Gynecology
keyword
keyword
109450
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"