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JOURNAL ARTICLE
Huiyu Cen, Mingna Sun, Bingyu Zheng, Weijie Peng, Qiqi Wen, Zhongxiao Lin, Xin Zhang, Na Zhou, Guanxiong Zhu, Xiyong Yu, Lingmin Zhang, Lu Liang
Verteporfin (VER), a photosensitizer used in macular degeneration therapy, has shown promise in controlling macrophage polarization and alleviating inflammation in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). However, its hydrophobicity, limited bioavailability, and side effects hinder its therapeutic potential. In this study, we aimed to enhance the therapeutic potential of VER through pulmonary nebulized drug delivery for ALI/ARDS treatment. We combined hydrophilic hyaluronic acid (HA) with an oil-in-water system containing a poly(lactic acid-co-glycolic acid) (PLGA) copolymer of VER to synthesize HA@PLGA-VER (PHV) nanoparticles with favorable surface characteristics to improve the bioavailability and targeting ability of VER...
April 4, 2024: International Journal of Biological Macromolecules
#22
JOURNAL ARTICLE
Anna Eligulashvili, Moshe Gordon, Jimmy S Lee, Jeylin Lee, Shiv Mehrotra-Varma, Jai Mehrotra-Varma, Kevin Hsu, Imanyah Hilliard, Kristen Lee, Arleen Li, Muhammed Amir Essibayi, Judy Yee, David J Altschul, Emad Eskandar, Mark F Mehler, Tim Q Duong
BACKGROUND: Acute neurological manifestation is a common complication of acute Coronavirus Disease 2019 (COVID-19) disease. This retrospective cohort study investigated the 3-year outcomes of patients with and without significant neurological manifestations during initial COVID-19 hospitalization. METHODS AND FINDINGS: Patients hospitalized for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection between 03/01/2020 and 4/16/2020 in the Montefiore Health System in the Bronx, an epicenter of the early pandemic, were included...
April 2024: PLoS Medicine
#23
Kha Minh Nguyen, Hai Phuong Nguyen Tran, Vi Tuong Dang, Sy Van Hoang
BACKGROUND: The persistent challenge of high mortality rates in acute myocardial infarction-induced cardiogenic shock endures notwithstanding advancements in the diagnosis and treatment of this disease over the past two decades. While recent studies present conflicting evidence on the efficacy of veno-arterial extracorporeal membrane oxygenation (VA ECMO), observational research supports the benefits of early VA ECMO initiation. However, the current lack of robust support from randomized clinical trials for VA ECMO use in this context highlights the ongoing uncertainty surrounding its effectiveness...
April 2024: European Heart Journal. Case Reports
#24
JOURNAL ARTICLE
Trine B Jonassen, Sofie E Jørgensen, Nikki H Mitchell, Trine H Mogensen, Ronan M G Berg, Andreas Ronit, Ronni R Plovsing
BACKGROUND: Type I interferon (IFN-I) and IFN autoantibodies play a crucial role in controlling SARS-CoV-2 infection. The levels of these mediators have only rarely been studied in the alveolar compartment in patients with COVID-19 acute respiratory distress syndrome (CARDS) but have not been compared across different ARDS etiologies, and the potential effect of dexamethasone (DXM) on these mediators is not known. METHODS: We assessed the integrity of the alveolo-capillary membrane, interleukins, type I, II, and III IFNs, and IFN autoantibodies by studying the epithelial lining fluid (ELF) volumes, alveolar concentration of protein, and ELF-corrected concentrations of cytokines in two patient subgroups and controls...
2024: Frontiers in Immunology
#25
JOURNAL ARTICLE
Yumi Mitsuyama, Hisatake Matsumoto, Yuki Togami, Sayaka Oda, Shinya Onishi, Jumpei Yoshimura, Arisa Murtatsu, Hiroshi Ito, Hiroshi Ogura, Daisuke Okuzaki, Jun Oda
BACKGROUND: Acute respiratory distress syndrome (ARDS) is respiratory failure that commonly occurs in critically ill patients, and the molecular mechanisms underlying its pathogenesis and severity are poorly understood. We evaluated mRNA and miRNA in patients with ARDS and elucidated the pathogenesis of ARDS after performing mRNA and miRNA integration analysis. METHODS: In this single-center, prospective, observational clinical study of patients with ARDS, peripheral blood of each patient was collected within 24 hours of admission...
2024: Frontiers in Immunology
#26
EDITORIAL
Narin Maclean, P Davies, S Lewis
Prone positioning is an intervention used for patients with acute respiratory distress syndrome (ARDS) whose hypoxia is worsening despite conventional treatment. Previously used infrequently, it became an important treatment escalation strategy for hypoxia during the COVID-19 pandemic. Current evidence for prone positioning suggests increased survivability in intubated patients with moderate to severe ARDS who are prone for >12 hours a day. As a relatively low-cost, low-tech intervention with a growing evidence base, the viability of prone positioning in the deployed land environment is considered in this article...
April 2, 2024: BMJ military health
#27
JOURNAL ARTICLE
Jing Wang, Zhong-Jin Chen, Ze-Yi Zhang, Mei-Ping Shen, Bo Zhao, Wei Zhang, Ye Zhang, Ji-Gang Lei, Cheng-Jie Ren, Jing Chang, Cui-Li Xu, Meng Li, Yang-Yang Pi, Tian-Lun Lu, Cheng-Xiang Dai, Su-Ke Li, Ping Li
BACKGROUND: Human adipose stromal cells-derived extracellular vesicles (haMSC-EVs) have been shown to alleviate inflammation in acute lung injury (ALI) animal models. However, there are few systemic studies on clinical-grade haMSC-EVs. Our study aimed to investigate the manufacturing, quality control (QC) and preclinical safety of clinical-grade haMSC-EVs. METHODS: haMSC-EVs were isolated from the conditioned medium of human adipose MSCs incubated in 2D containers...
April 2, 2024: Stem Cell Research & Therapy
#28
JOURNAL ARTICLE
Vikram B Gondhalekar, Amir Gandomi, Sarah L Gilman, Negin Hajizadeh, Zubair M Hasan, Matthew A Bank, Daniel M Rolston, Allison Cohen, Timmy Li, Mitsuaki Nishikimi, Mangala Narasimhan, Lance Becker, Daniel Jafari
OBJECTIVES: Nonconventional ventilators (NCVs), defined here as transport ventilators and certain noninvasive positive pressure devices, were used extensively as crisis-time ventilators for intubated patients with COVID-19. We assessed whether there was an association between the use of NCV and higher mortality, independent of other factors. DESIGN: This is a multicenter retrospective observational study. SETTING: The sample was recruited from a single healthcare system in New York...
April 2, 2024: Critical Care Medicine
#29
JOURNAL ARTICLE
Ioannis Grigoropoulos, Georgios Tsioulos, Artemis Kastrissianakis, Shiran Shapira, Orr Green, Vasiliki Rapti, Maria Tsakona, Thomas Konstantinos, Athina Savva, Dimitra Kavatha, Dimitrios Boumpas, Konstantinos Syrigos, Ioannis Xynogalas, Konstantinos Leontis, Vasileios Ntousopoulos, Vissaria Sakka, Zafeiris Sardelis, Andreas Fotiadis, Lamprini Vlassi, Chrysoula Kontogianni, Anastasia Levounets, Garyfalia Poulakou, Mina Gaga, Ronan MacLoughlin, Justin Stebbing, Nadir Arber, Anastasia Antoniadou, Sotirios Tsiodras
INTRODUCTION: EXO-CD24 are exosomes genetically manipulated to over-express Cluster of Differentiation (CD) 24. It consists of two breakthrough technologies: CD24, the drug, as a novel immunomodulator that is smarter than steroids without any side effects, and exosomes as the ideal natural drug carrier. METHODS: A randomized, single blind, dose-finding phase IIb trial in hospitalized patients with mild to moderate Coronavirus disease 2019 (COVID-19) related Acute Respiratory Distress Syndrome (ARDS) was carried out in two medical centers in Athens...
April 1, 2024: Respiratory Research
#30
JOURNAL ARTICLE
Gang Li, Ke Yan, Wanyi Zhang, Haiyan Pan, Pengxiang Guo
BACKGROUND: Acute Respiratory Distress Syndrome (ARDS) is a common condition in the intensive care unit (ICU) with a high mortality rate, yet the diagnosis rate remains low. Recent studies have increasingly highlighted the role of aging in the occurrence and progression of ARDS. This study is committed to investigating the pathogenic mechanisms of cellular and genetic changes in elderly ARDS patients, providing theoretical support for the precise treatment of ARDS. METHODS: Gene expression profiles for control and ARDS samples were obtained from the Gene Expression Omnibus (GEO) database, while aging-related genes (ARGs) were sourced from the Human Aging Genomic Resources (HAGR) database...
2024: Frontiers in Immunology
#31
REVIEW
Marco Prato, Natalia Tiberti, Cristina Mazzi, Federico Gobbi, Chiara Piubelli, Silvia Stefania Longoni
The RAS is a hormonal system playing a pivotal role in the control of blood pressure and electrolyte homeostasis, the alteration of which is associated with different pathologies, including acute respiratory distress syndrome (ARDS). As such, it is not surprising that a number of studies have attempted to elucidate the role and balance of the renin-angiotensin system (RAS) in COVID-19. In this review article, we will describe the evidence collected regarding the two main enzymes of the RAS (i.e., ACE and ACE2) and their principal molecular products (i...
March 14, 2024: Microorganisms
#32
REVIEW
Łukasz Huminiecki
Coronavirus disease 2019 (COVID-19) is a type of pneumonia caused by the SARS-CoV-2 coronavirus. It can cause acute pulmonary and systemic inflammation, which can lead to death in severely ill patients. This study explores the potential reasons behind severe COVID-19 and its similarities to systemic autoimmune diseases. This study reviewed unbiased high-throughput gene expression datasets, including next-generation and single-cell RNA sequencing. A total of 27 studies and eight meta-analyses were reviewed. The studies indicated that severe COVID-19 is associated with the upregulation of genes involved in pro-inflammatory, interferon, and cytokine/chemokine pathways...
March 14, 2024: International Journal of Molecular Sciences
#33
REVIEW
Tatsiana Romenskaya, Yaroslava Longhitano, Aman Mahajan, Gabriele Savioli, Antonio Voza, Manfredi Tesauro, Christian Zanza
Extracorporeal membrane oxygenation (ECMO) is a cardiac or pulmonary function support system that is used in cases of refractory organ failure in addition to conventional treatment. Currently, Level I evidence is not yet available, which reflects improved outcomes with ECMO in pregnant women, the use in pregnancy should be indicated in selected cases and only in specialized centers. We searched articles in the most important scientific databases from 2009 until 31 December 2023 consulting also the site ClinicalTrials...
March 13, 2024: Journal of Clinical Medicine
#34
JOURNAL ARTICLE
Hua Jin, Yue Zhao, Yinlian Yao, Shilong Fan, Renxing Luo, Xin Shen, Yanyan Wang, Jiang Pi, Gonghua Huang
Cytokine storm and ROS overproduction in the lung always lead to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) in a very short time. Effectively controlling cytokine storm release syndrome (CRS) and scavenging ROS are key to the prevention and treatment of ALI/ARDS. In this work, the naringin nanoparticles (Nar-NPs) were prepared by the emulsification and evaporation method; then, the mesenchymal stem cell membranes (CMs) were extracted and coated onto the surface of the Nar-NPs through the hand extrusion method to obtain the biomimetic CM@Nar-NPs...
February 26, 2024: Antioxidants (Basel, Switzerland)
#35
REVIEW
Vitalii Kryvenko, István Vadász
Acute respiratory distress syndrome (ARDS) is associated with high morbidity and mortality but lacks specific therapeutic options. Diverse endocytic processes play a key role in all phases of acute lung injury (ALI), including the initial insult, development of respiratory failure due to alveolar flooding, as a consequence of altered alveolar-capillary barrier function, as well as in the resolution or deleterious remodeling after injury. In particular, clathrin-, caveolae-, endophilin- and glycosylphosphatidyl inositol-anchored protein-mediated endocytosis, as well as, macropinocytosis and phagocytosis have been implicated in the setting of acute lung damage...
2024: Frontiers in Immunology
#36
JOURNAL ARTICLE
Tommaso Pozzi, Silvia Coppola, Elena Chiodaroli, Federico Cucinotta, Francesca Becci, Davide Chiumello
PURPOSE: The Prone positioning in addition to non invasive respiratory support is commonly used in patients with acute respiratory failure. The aim of this study was to assess the accuracy of an impedance-based non-invasive respiratory volume monitor (RVM) in supine and in prone position. METHODS: In sedated, paralyzed and mechanically ventilated patients in volume-controlled mode with acute respiratory distress syndrome scheduled for prone positioning it was measured and compared non-invasively tidal volume and respiratory rate provided by the RVM in supine and, subsequently, in prone position, by maintaining unchanged the ventilatory setting...
March 26, 2024: Journal of Clinical Monitoring and Computing
#37
JOURNAL ARTICLE
Anoop Kumar As, Rima R Sahay, Chandni Radhakrishnan, Shihabudheen P, Sathishkumar Kandath, Deepak Y Patil, Anita M Shete, Shamsudheen M, Gayathri Ramakrishnan, Anitha Puduvail Moorkoth, Nivedita Gupta, Pragya D Yadav, Sheela Godbole, Lathika Velichapat Ramakrishnan, Shameer Vadekkandiyil, Danish Ekkalayil, Nithasha V, Anukumar Balakrishnan, Niyas K Pullor, Neelakandhan Asokan, Reena Kalathil Joseph, Priyanka R Nair, Sreejayan Meethale Purayil, Thomas Mathew, Rajaram Kizhakkekandiyil, Jayesh Kumar Poovullathil, Kannan Sabarinath Ps, Ullas Pt, Kalpana George, Asma Rahim, Surendra Kumar, Siba S, Sreelekshmy Mohandas, Lekshmi S Rajan, Shamin Punnath Ramachandran, Seethu Ponnu Thampi, Ashadevi, Thekkumkara Surendran Anish, Priya Chandran, Anuja Mohan, Bindu Vadakkayil, Shaji Cheriya Koroth, Nimin Hafeez, Rajasi Ranjini Sasi, Minu Abraham
India experienced its sixth Nipah virus (NiV) outbreak in September 2023 in the Kozhikode district of Kerala state. The NiV is primarily transmitted by spillover events from infected bats followed by human-to-human transmission. The clinical specimens were screened using real-time RT-PCR, and positive specimens were further characterized using next-generation sequencing. We describe here an in-depth clinical presentation and management of NiV-confirmed cases and outbreak containment activities. The current outbreak reported a total of six cases with two deaths, with a case fatality ratio of 33...
March 2024: Journal of Medical Virology
#38
JOURNAL ARTICLE
Chunxia Wang, Jianli Zheng, Yilin Zhao, Tiantian Liu, Yucai Zhang
OBJECTIVE: Oxygen and hemodynamic management are important for providing a sufficient adequate oxygen-containing blood to the organs for septic patients. In present study, we aimed to explore the application of sequential respiratory support (SRS) and the association of SRS with the outcome of septic patients who needed continuous renal replacement therapy (CRRT). METHODS: We extracted the medical information of septic patients who received CRRT within 24 h of intensive care unit (ICU) admission from the MIMIC-III v1...
March 30, 2024: Heliyon
#39
JOURNAL ARTICLE
Martina Part
The purpose of the article: Generalized pustular psoriasis (GPP) is a rare auto-inflammatory disease. Patients with GPP may develop life-threatening complications, including sepsis, acute renal failure, neutrophilic cholangitis, high-output congestive heart failure, acute respiratory distress syndrome and death. The therapy of GPP is very limited and the course of the disease is unpredictable. Materials and methods: We report a 60-year-old woman presenting with widespread and confluent erythematous-desquamative plaques with numerous small pustules covering almost 70% of the body surface area...
December 2024: Journal of Dermatological Treatment
#40
REVIEW
Yitianhe Xu, Leyao Lv, Qian Wang, Qing Yao, Longfa Kou, Hailin Zhang
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are serious lung injuries caused by various factors, leading to increased permeability of the alveolar-capillary barrier, reduced stability of the alveoli, inflammatory response, and hypoxemia. Despite several decades of research since ARDS was first formally described in 1967, reliable clinical treatment options are still lacking. Currently, supportive therapy and mechanical ventilation are prioritized, and there is no medication that can be completely effective in clinical treatment...
March 21, 2024: Colloids and Surfaces. B, Biointerfaces
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