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Uterus transplantation

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https://www.readbyqxmd.com/read/27915038/intrauterine-administration-of-hcg-activated-autologous-human-peripheral-blood-mononuclear-cells-pbmc-promotes-live-birth-rates-in-frozen-thawed-embryo-transfer-cycles-of-patients-with-repeated-implantation-failure
#1
Saijiao Li, Jing Wang, Yan Cheng, Danni Zhou, Tailang Yin, Wangming Xu, Nan Yu, Jing Yang
Recurrent implantation failure refers to unsuccessful implantation after repeated transfers of morphologically good quality embryos into a normal uterus. Recently, accumulating evidence has suggested that local immune cells at the implantation site have actively contributed to embryo implantation. Our aim was to study the effects of intrauterine administration of hCG-activated autologous human PBMC on clinical pregnancy, implantation rates and live birth rate of patients who received frozen/thawed embryo transfer...
November 27, 2016: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/27873528/transplantation-of-vascularized-composite-allografts-review-of-current-knowledge
#2
M Molitor
Transplantation in reconstructive surgery has been performed for more than 20 years, although the official beginning of these procedures is considered the first successful transplantation of the hand in 1998. The original name "Composite Tissue Transplantation" has been used less frequently; more common is the term "Vascularized Composite Allotransplant", which better describes the basis of the procedure. There have been so far approximately 180 transplantations performed, the exact number is difficult to find...
2016: Acta Chirurgiae Plasticae
https://www.readbyqxmd.com/read/27868389/monitoring-of-human-uterus-transplantation-with-cervical-biopsies-a-provisional-scoring-system-for-rejection
#3
J Mölne, V Broecker, J Ekberg, O Nilsson, P Dahm-Kähler, M Brännström
Until now, absolute uterine factor infertility has been the major untreatable form of female infertility. Recently, uterus transplantation has proven to be the first successful treatment for absolute uterine factor infertility, with demonstration of live births. Here, live donation uterus transplantation was performed in nine women. 163 cervical biopsies (149 protocol, 14 follow-up) were taken to detect histopathological signs of rejection. Based on experience from animal experiments, we used a three-grade scoring system to evaluate biopsies systematically...
November 21, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27814762/risk-of-adverse-pregnancy-and-perinatal-outcomes-after-high-technology-infertility-treatment-a-comprehensive-systematic-review
#4
REVIEW
Stefano Palomba, Roy Homburg, Susanna Santagni, Giovanni Battista La Sala, Raoul Orvieto
In the literature, there is growing evidence that subfertile patients who conceived after infertility treatments have an increased risk of pregnancy and perinatal complications and this is particularly true for patients who conceived through use of high technology infertility treatments. Moreover, high technology infertility treatments include many concomitant clinical and biological risk factors. This review aims to summarize in a systematic fashion the current evidence regarding the relative effect of the different procedures for high technology infertility treatments on the risk of adverse pregnancy and perinatal outcome...
November 4, 2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27786258/surgical-technique-for-allogeneic-uterus-transplantation-in-macaques
#5
Hideaki Obara, Iori Kisu, Yojiro Kato, Yohei Yamada, Kentaro Matsubara, Katsura Emoto, Masataka Adachi, Yusuke Matoba, Kiyoko Umene, Yuya Nogami, Kouji Banno, Hideaki Tsuchiya, Iori Itagaki, Ikuo Kawamoto, Takahiro Nakagawa, Hirohito Ishigaki, Yasushi Itoh, Kazumasa Ogasawara, Yoko Saiki, Shin-Ichi Sato, Kenshi Nakagawa, Takashi Shiina, Daisuke Aoki, Yuko Kitagawa
No study has reported an animal model of uterus transplantation (UTx) using cynomolgus macaques. We aimed to establish a surgical technique of allogeneic UTx assuming the recovery of a uterus from a deceased donor in cynomolgus macaques. Four allogeneic UTxs were performed in female cynomolgus macaques. Donor surgeries comprised en bloc recovery of organs with iliac vessels on both sides, and/or abdominal aorta/vena cava after sufficient perfusion from one femoral artery or external iliac artery. Before perfusion, 150 mL of whole blood was obtained from the donor for subsequent blood transfusion to the recipient...
October 27, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27774233/other-women-s-wombs-uterus-transplants-and-gestational-surrogacy
#6
John A Robertson
The birth of a child after uterus transplant from a living donor in Sweden in October, 2013 has spurred reproductive and transplant physicians in Europe and North America to investigate whether uterus transplants, from living or cadaveric donors, will be a safe and effective therapy for women with uterine insufficiency. While progress with uterus transplant depends on medical factors, there are also important ethical and legal concerns. Uterus transplant is essential for women without access to surrogacy. It may also be sought by infertile women who dislike surrogacy...
April 2016: Journal of Law and the Biosciences
https://www.readbyqxmd.com/read/27754594/living-donor-uterus-transplant-and-surrogacy-ethical-analysis-according-to-the-principle-of-equipoise
#7
G Testa, E C Koon, L Johannesson
The uterus is the most recent addition to the list of organs that can be successfully transplanted in humans. This article analyzes living donor uterus transplantation according to the ethical principle of equipoise. A comparison is made between living donor uterus transplantation and gestational surrogate motherhood. Both are solutions to absolute uterine infertility that allow the transfer of genetic material from intended parents to a child. The analysis concludes that living donor uterus transplantation does not violate the ethical principle of equipoise and should be considered an ethically acceptable solution to absolute uterine infertility...
October 18, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27720095/uterine-transplants-in-the-canadian-setting-a-theoretical-framework
#8
Jacques Balayla
The uterine transplant is an innovative surgical procedure whereby a healthy uterus is transplanted into a woman with uterine factor infertility (UFI) for the purpose of procreation. Twelve uterine transplants have been attempted in the world in the last two decades, and five have led to viable births. While uterine transplantation is still in its experimental stages, it remains unclear whether Canadian centres plan to attempt the procedure in the near future. Herein, I raise several observations that are specific to the Canadian setting and apply the Montreal Criteria for the Ethical Feasibility of Uterine Transplantation to determine whether there is fertile ground for a uterine transplantation program to be adopted in Canada...
October 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/27716570/ectopic-pregnancy-in-simultaneous-pancreas-kidney-transplantation-a-case-report
#9
Shinji Yamamoto, Maria Nelander
INTRODUCTION: We present a case report of ectopic pregnancy (EP) after simultaneous pancreas-kidney transplantation (SKPTx). PRESENTATION OF CASE: A 33-year-old female status post SKPTx suddenly got abdominal pain in the lower level. She had high human chorionic Gonadotropin test. Ultrasonography revealed that there was no fetus in the uterus but a dilated right fallopian tube, which strongly suggested ectopic pregnancy. An emergency operation was performed and a dilated right side uterine tube was found with adhesions to her transplant...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27664218/autologous-menstrual-blood-derived-stromal-cells-transplantation-for-severe-asherman-s-syndrome
#10
Jichun Tan, Pingping Li, Qiushi Wang, Yaxuan Li, Xiaoni Li, Dongni Zhao, Xiaoyan Xu, Lin Kong
STUDY QUESTION: Does autologous transplantation of menstrual blood-derived stromal cells (menSCs) regenerate endometrium to support pregnancy in patients with severe Asherman's syndrome (AS)? SUMMARY ANSWER: Autologous menSCs transplantation significantly increases endometrial thickness (ET) for women with severe AS. WHAT IS KNOWN ALREADY: AS is a major cause of secondary infertility in women. Cell transplantation has been tried in a few clinical cases with encouraging results...
September 22, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27650562/deceased-donor-uterus-retrieval-the-first-czech-experience
#11
J Froněk, L Janousek, R Chmel
INTRODUCTION: Uterus transplantation is the youngest solid organ transplantation described in the literature. This procedure is the only treatment method for congenital or acquired Absolute Uterine Factor Infertility. METHOD: The method is not recognised as standard clinical care yet, there were only some 13 cases performed worldwide so far. There is only one clinical trial worldwide, which has proven both feasibility and also healthy child delivery. RESULTS: Czech Republic Ministry of Health permitted the uterus transplant clinical trial in 2015...
2016: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/27640423/uterus-human-leucocyte-antigen-expression-in-the-perspective-of-transplantation
#12
Tristan Gauthier, Matthieu Filloux, Angelique Guillaudeau, Marie Essig, Romain Bibes, Adam Fodil Pacha, Pascal Piver, Yves Aubard, Pierre Marquet, Mireille Drouet
AIM: To describe class I and II human leucocyte antigen (HLA) expression using different uterine tissues in the perspective of uterus transplantation. METHODS: Human uterine tissues were obtained from 12 women who had undergone hysterectomy for the treatment of benign disease. HLA class I and HLA-antigen D related (DR) expression were assessed via immunochemistry. HLA class I expression in the uterus was compared with expression in other organs and tissues, including kidney and myocardium samples...
September 19, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27638900/uterus-transplantation-from-animal-models-through-the-first-heart-beating-pregnancy-to-the-first-human-live-birth
#13
REVIEW
Omer Ozkan, Nasuh Utku Dogan, Ozlenen Ozkan, Inanc Mendilcioglu, Selen Dogan, Batu Aydinuraz, Mehmet Simsek
Absolute uterine factor infertility affects 3-5% of the general population, and unfortunately this condition is untreatable. There are some available options, including surrogacy or adoption, but neither of these suits each and every woman who desires to have her own genetic child. With recent advances in surgery and transplant immunology, uterus transplantation may be a source of hope for these women with uterine infertility. In the last decade, a number of animal species including rats, mice, rabbits, pigs, sheep, and primates have been used as experimental models, and pregnancies were achieved in some of these...
July 2016: Women's Health
https://www.readbyqxmd.com/read/27614987/application-of-bone-marrow-derived-mesenchymal-stem-cells-in-the-treatment-of-intrauterine-adhesions-in-rats
#14
Jianmei Wang, Baohui Ju, Caijun Pan, Yan Gu, Yu Zhang, Li Sun, Bumei Zhang, Yujuan Zhang
AIMS: To investigate the therapeutic effects of bone marrow-derived mesenchymal stem cells (BMSCs) transplantation on intrauterine adhesions (IUA). METHODS: BMSCs were isolated and labeled by green fluorescence protein. IUA model was established by mechanical injury. 48 rats were randomly divided into control, IUA model, BMSCs vein injection and BMSCs intrauterine injection groups (n=12 in each group). The third generation of BMSCs was injected through tail vein or intrauterine...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27607535/which-donor-for-uterus-transplants-brain-dead-donor-or-living-donor-a-systematic-review
#15
Vincent Lavoué, Cécile Vigneau, Solène Duros, Karim Boudjema, Jean Levêque, Pascal Piver, Yves Aubard, Tristan Gauthier
BACKGROUND: The aim of this systematic review was to evaluate and compare the pros and cons of using living donors or brain-dead donors in uterus transplantation programs, 2 years after the first worldwide live birth after uterus transplantation. METHODS: The Medline database and the Central Cochrane Library were used to locate uterine transplantation studies carried out in human or non-human primates. All types of articles (case reports, original studies, meta-analyses, reviews) in English or French were considered for inclusion...
September 8, 2016: Transplantation
https://www.readbyqxmd.com/read/27602224/cancer-risk-in-patients-receiving-renal-replacement-therapy-a-meta-analysis-of-cohort-studies
#16
Weifeng Shang, Liu Huang, Li Li, Xiaojuan Li, Rui Zeng, Shuwang Ge, Gang Xu
It has been reported that patients receiving renal replacement therapy (RRT), including dialysis and kidney transplantation, tend to have an increased risk of cancer; however, studies on the degree of this risk have remained inconclusive. The present meta-analysis was therefore performed to quantify the cancer risk in patients with RRT. Cohort studies assessing overall cancer risk in RRT patients published before May 29, 2015 were included following systematic searches with of PubMed, EMBASE and the reference lists of the studies retrieved...
September 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27552172/uterus-transplantation-in-france-for-which-patients
#17
S Huet, A Tardieu, M Filloux, M Essig, N Pichon, J F Therme, P Piver, Y Aubard, J M Ayoubi, O Garbin, P Collinet, A Agostini, V Lavoue, A Piccardo, T Gauthier
OBJECTIVE: Uterine infertility (UI), which can be caused by a variety of congenital or acquired factors, affects several thousand women in Europe. Uterus transplantation (UTx), at the current stage of research, offers hope for these women to be both the biological mother and the carrier of their child. However, the indications of UTx still need to be defined. The main aim of the study was to describe the different etiologies of UI and other data as marital and parental status from women requesting UTx who contacted us in the framework of a UTx clinical trial...
October 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27535958/aberrant-endometrial-dna-methylome-and-associated-gene-expression-in-endometriosis
#18
Sahar Houshdaran, Camran R Nezhat, Kim Chi Vo, Zara Zelenko, Juan C Irwin, Linda C Giudice
Endometriosis is an estrogen-dependent, progesterone-resistant disorder largely derived from retrograde transplantation of menstrual tissue/cells into the pelvis, eliciting an inflammatory response, pelvic pain and infertility. Eutopic endometrium (within the uterus), giving rise to pelvic disease, displays cycle-dependent transcriptomic, proteomic, and signaling abnormalities, and while its DNA methylation profiles dynamically change across the cycle in healthy women, studies in endometriosis are limited. Herein, we investigated the DNA methylome and associated gene expression in three phases of the cycle in eutopic endometrium of women with severe endometriosis versus controls, matched for ethnicity, medications, smoking, and no recent contraceptive steroid use...
August 17, 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/27524411/prostaglandin-levels-vaginal-innervation-and-cyst-innervation-as-peripheral-contributors-to-endometriosis-associated-vaginal-hyperalgesia-in-rodents
#19
Stacy L McAllister, Barbra K Giourgas, Elizabeth K Faircloth, Emma Leishman, Heather B Bradshaw, Eric R Gross
Endometriosis is a painful condition characterized by growth of endometrial cysts outside the uterus. Here, we tested the hypothesis that peripheral innervation and prostaglandin levels contribute to endometriosis-associated pain. Female Sprague-Dawley rats (n = 16) were surgically instrumented by transplanting uterine tissue onto mesenteric arteries within the peritoneal cavity to create a model of endometriosis which forms extra-uterine endometrial cysts and vaginal hyperalgesia. Our results describe a significant positive correlation between endometriosis-induced vaginal hyperalgesia and cyst innervation density (sensory, r = 0...
December 5, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27521259/public-funding-social-change-and-uterus-transplants-a-response-to-commentaries
#20
Stephen Wilkinson, Nicola Jane Williams
No abstract text is available yet for this article.
September 2016: Journal of Medical Ethics
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