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Uterus transplantation

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https://www.readbyqxmd.com/read/29980257/uterus-transplantation-organ-procurement-in-a-deceased-donor-model
#1
Elliott G Richards, Rebecca Flyckt, Andreas Tzakis, Tommaso Falcone
OBJECTIVE: To demonstrate our technique of uterine procurement from a deceased donor. DESIGN: This video uses live action footage from surgery and detailed illustrations to review the steps and techniques involved in deceased donor procurement surgery. SETTING: Academic medical center. PATIENT(S): A deceased multiorgan donor. INTERVENTION(S): Trial organ procurement of a viable uterus from a deceased donor...
July 1, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29980256/endometrial-regeneration-using-cell-sheet-transplantation-techniques-in-rats-facilitates-successful-fertilization-and-pregnancy
#2
Goro Kuramoto, Tatsuya Shimizu, Soichi Takagi, Ken Ishitani, Hideo Matsui, Teruo Okano
OBJECTIVE: To regenerate functional endometrium tissue using "cell sheet" techniques as a regenerative medicine approach to address endometrial disorders causing female factor infertility. DESIGN: In vivo experimental study. SETTING: Preclinical surgical and biomedical research laboratories. ANIMAL(S): Green fluorescent protein (GFP) transgenic rats [SD-Tg (CAG-EGFP) rats] and nude rats (F344/NJcl-rnu/rnu)...
July 1, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29974599/basic-research-on-uterus-transplantation-in-nonhuman-primates-in-japan
#3
REVIEW
Iori Kisu, Kouji Banno, Yusuke Matoba, Masataka Adachi, Daisuke Aoki
Uterus transplantation (UTx) is now a potential option for women with uterine factor infertility to have a child. However, UTx is still in an experimental stage and basic animal studies including in nonhuman primates are needed for accumulation of data that will provide important information for establishment of UTx in humans. Herein, we summarized our experiences using cynomolgus macaques, with the goal of promoting further development of UTx studies in nonhuman primates. Our basic studies using cynomolgus macaques were summarized, including the results of other teams in nonhuman primates...
July 5, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29869370/emerging-problems-in-uterus-transplantation
#4
I Kisu, Y Kato, H Obara, K Matsubara, Y Matoba, K Banno, D Aoki
No abstract text is available yet for this article.
June 4, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29751094/the-interest-of-women-with-mayer-rokitansky-k%C3%A3-ster-hauser-syndrome-and-laparoscopic-vecchietti-neovagina-in-uterus-transplantation
#5
Roman Chmel, Marta Novackova, Zlatko Pastor, Jiri Fronek
STUDY OBJECTIVE: The goal of this study was to assess a group of Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) women with surgically created neovaginas in the interest of uterus transplantation (UTx) and to recruit the first group of applicants for a uterus transplant trial. DESIGN: and Setting: This is an original prospective study using semistructured interviews. PARTICIPANTS: A study group of 50 MRKH syndrome women with Vecchietti neovaginas was recruited by letter of invitation...
May 8, 2018: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29701160/non-pregnant-human-uterus-as-source-of-mesenchymal-stem-cells
#6
Noemi Eiro, Maria Fraile, Jose Schneider, Francisco Vizoso
Stem/progenitor cells for cell therapy and regenerative medicine should ideally be available in large numbers, after having been isolated using minimally invasive or non-invasive methodologies. Also, they should exhibit wide differentiation potential into multiple lineages, as well as capability to be used successfully in autologous or allogeneic transplantation, and all this in accordance with the applicable guidelines of good manufacturing practice. Thus, the identification and characterization of alternative sources of mesenchymal stem cells (MSCs) is of great importance...
April 26, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29649618/preimplantation-high-resolution-hla-sequencing-using-next-generation-sequencing
#7
Maryam Rafati, Mohammad Mahdi Akhondi, Mohammad Reza Sadeghi, Seyedeh Zahra Tara, Saeed Reza Ghaffari
Hematopoietic stem cell transplantation (SCT) is the only therapeutic option in a number of heritable hematologic disorders and hematologic cancers. Many parents and families fail to find an HLA-identical donor for their affected family member. In such cases, conceiving for a "savior baby" remains the only option, especially in countries without access to national registries. By means of next generation sequencing (NGS) techniques, in a single experiment on single-cell products of in vitro fertilization, a healthy HLA-identical embryo can be implanted in the uterus of a concerned mother...
April 9, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29628366/-uterus-transplant-or-gestational-surrogacy-is-there-a-possible-choice
#8
EDITORIAL
D Raudrant, P Madelenat, B Salle
No abstract text is available yet for this article.
April 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29621960/experimental-uterus-transplant-in-various-models-review-of-surgical-techniques
#9
Jalal Arvin, Maryam Ashrafi, Saeedeh Lotfi, Arash Dadvand Meshgin Shahr, Elvira Schomann, Kristina Scheerer, Elke Schulmeyer
Uterus transplantation may become the surgical therapeutic modality of choice for uterine factor infertility. However, this procedure still faces technical, therapeutic, and immunologic challenges that limit its success and clinical application. Experimental studies are therefore still needed to address various challenges in the field of uterus transplantation. Among various laboratory animals, small animals are ideal models for the purpose of experimental uterus transplant. However, clinical success in small animal models is not generalizable to clinical application and treatment for uterine factor infertility in humans...
April 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29615065/efficacy-safety-and-recurrence-of-new-progestins-and-selective-progesterone-receptor-modulator-for-the-treatment-of-endometriosis-a-comparison-study-in-mice
#10
Bo Liang, Ling Wu, Hui Xu, Chun Wai Cheung, Wen Ying Fung, Sze Wai Wong, Chi Chiu Wang
BACKGROUND: Current medical treatments for endometriosis are very limited. Progestin and selective progesterone receptor modulators (SPRM) are developed but their efficacy, safety, mechanism and recurrence in endometriosis are not fully studied. METHODS: In order to compare therapeutic, side effects and therapeutic actions of Esmya, Duphaston and Dienogest in endometriosis. Experimental endometriosis was induced by either intraperitoneal or subcutaneous mouse endometrium transplantation...
April 3, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29575738/first-live-birth-after-uterus-transplantation-in-the-united-states
#11
G Testa, G J McKenna, R T Gunby, T Anthony, E C Koon, A M Warren, J M Putman, L Zhang, G dePrisco, J M Mitchell, K Wallis, G B Klintmalm, M Olausson, L Johannesson
Uterus transplantation has proven to be a successful treatment for women with absolute uterine infertility, caused either by the absence of a uterus or the presence of a nonfunctioning uterus. We report the first birth of a healthy child following uterus transplantation in the United States, from a recipient of a uterus allograft procured from an altruistic living donor. Two major modifications from the previously reported live births characterized this uterus transplant. First, the transplanted uterus relied upon and sustained the pregnancy while having only the utero-ovarian vein as venous outflow...
May 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29571018/stem-cell-therapy-in-asherman-syndrome-and-thin-endometrium-stem-cell-based-therapy
#12
REVIEW
Ramyar Azizi, Leili Aghebati-Maleki, Mohammad Nouri, Faroogh Marofi, Sohrab Negargar, Mehdi Yousefi
The endometrium is one of the essential components of the uterus. The endometrium of human is a complex and dynamic tissue, which undergoes periods of growth and turn over during any menstrual cycle. Stem cells are initially undifferentiated cells that display a wide range of differentiation potential with no distinct morphological features. Stem cell therapy method recently has become a novel procedure for treatment of tissue injury and fibrosis in response to damage. Currently, there is massive interest in stem cells as a novel treatment method for regenerative medicine and more specifically for the regeneration of human endometrium disorder like Asherman syndrome (AS) and thin endometrium...
June 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29524724/a-survey-of-public-opinion-in-the-united-states-regarding-uterine-transplantation
#13
Eduardo Hariton, Pietro Bortoletto, Randi H Goldman, Leslie V Farland, Elizabeth S Ginsburg, Antonio R Gargiulo
STUDY OBJECTIVE: To evaluate the opinions and attitudes of the general public regarding uterine transplantation (UTx) in the United States. DESIGN: A cross-sectional study (Canadian Task Force classification II-2). SETTING: A Web-based survey. PATIENTS: A nationally representative sample of adult US residents by age and sex. INTERVENTIONS: A Web-based questionnaire administered in November 2016...
March 7, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29516621/transplant-of-insulin-like-growth-factor-1-expressing-bone-marrow-stem-cells-improves-functional-regeneration-of-injured-rat-uterus-by-nf-%C3%AE%C2%BAb-pathway
#14
Lei Wang, Mengnan Yang, Minfei Jin, Yuelin Wu, Tao Zheng, Shengyi Gu, Xiaolin Hua
To investigate the potential beneficial effect of insulin-like growth factor-1 (IGF-1) in BMSC transplantation therapy of uterus injury and the underlying molecular mechanisms, rat BMSCs were isolated and cultured. The relative expressions of IGF-1 and IL-10 were determined by RT-PCR and immunoblotting. The secretory IL-10 and released E2 were measured using ELISA kits. The relative vWF and α-SMA expressions were determined by immunohistochemistry. The direct binding of NF-κB subunit p50 with IL-10 promoter was analysed by chromatin immunoprecipitation assay...
May 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29501812/uterine-transplantation-a-survey-of-perceptions-and-attitudes-of-american-reproductive-endocrinologists-and-gynecologic-surgeons
#15
Pietro Bortoletto, Eduardo Hariton, Leslie V Farland, Randi H Goldman, Antonio R Gargiulo
OBJECTIVE: To determine whether reproductive endocrinologists and minimally invasive surgeons support uterine transplantation as a treatment option for absolute uterine factor infertility (AUFI). DESIGN: A cross-sectional study (Canadian Task Force classification II-2). SETTING: A Web-based survey. PATIENTS: Physician members of the American Society of Reproductive Medicine (ASRM) and the American Association of Gynecologic Laparoscopists (AAGL)...
March 2, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29450941/hematogenous-dissemination-of-mesenchymal-stem-cells-from-endometriosis
#16
Fei Li, Myles H Alderman, Aya Tal, Ramanaiah Mamillapalli, Alexis Coolidge, Demetra Hufnagel, Zhihao Wang, Elham Neisani, Stephanie Gidicsin, Graciela Krikun, Hugh S Taylor
Endometriosis is ectopic growth of endometrial tissue traditionally thought to arise through retrograde menstruation. We aimed to determine if cells derived from endometriosis could enter vascular circulation and lead to hematogenous dissemination. Experimental endometriosis was established by transplanting endometrial tissue from DsRed+ mice into the peritoneal cavity of DsRed- mice. Using flow cytometry, we identified DsRed+ cells in blood of animals with endometriosis. The circulating donor cells expressed CXCR4 and mesenchymal stem cell (MSC) biomarkers, but not hematopoietic stem cell markers...
February 16, 2018: Stem Cells
https://www.readbyqxmd.com/read/29444715/porcine-wharton-s-jelly-cells-distribute-throughout-the-body-after-intraperitoneal-injection
#17
Kreeson Packthongsuk, Theresa Rathbun, Deryl Troyer, Duane L Davis
BACKGROUND: Wharton's jelly cells (WJCs) have multiple differentiation potentials and are easily harvested in large numbers. WJCs are well tolerated in allogeneic environments and there is a growing list of their therapeutic effects. Most therapies require administering large numbers of cells and this is generally accomplished by intravenous injection. Here, we studied the locations of porcine WJCs in immune-competent, allogeneic hosts after intraperitoneal (IP) injection. METHODS: Male porcine WJCs were administered to female neonatal piglets by IP injection...
February 14, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29433563/therapeutic-effect-of-human-umbilical-cord-derived-mesenchymal-stem-cells-on-injured-rat-endometrium-during-its-chronic-phase
#18
Lu Zhang, Ying Li, Chun-Yi Guan, Shi Tian, Xiao-Dan Lv, Jian-Hui Li, Xu Ma, Hong-Fei Xia
BACKGROUND: Repair deficiency after endometrial injury is an important reason for intra-uterine adhesions, amenorrhea, and infertility in females. Bone marrow-derived mesenchymal stem cell (BMSC) transplantation is effective in repairing the damaged endometrium. However, the possibility of using umbilical cord-derived MSCs (UC-MSCs) to treat endometrial injury is rarely reported. METHODS: Ethanol (95%) was injected into rat uterus to establish a model of endometrial injury...
February 13, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29423621/uterine-transplant-a-risk-to-life-or-a-chance-for-life
#19
Alankrita Taneja, Siddhartha Das, Syed Ather Hussain, Mohammed Madadin, Stany Wilfred Lobo, Huda Fatima, Ritesh G Menezes
Being inherently different from any other lifesaving organ transplant, uterine transplantation does not aim at saving lives but supporting the possibility to generate life. Unlike the kidneys or the liver, the uterus is not specifically a vital organ. Given the non-lifesaving nature of this procedure, questions have been raised about its feasibility. The ethical dilemma revolves around whether it is worth placing two lives at risk related to surgery and immunosuppression, amongst others, to enable a woman with absolute uterine factor infertility to experience the presence of an organ enabling childbirth...
February 8, 2018: Science and Engineering Ethics
https://www.readbyqxmd.com/read/29395094/robotic-assisted-surgery-in-live-donor-uterus-transplantation
#20
EDITORIAL
Mats Brännström, Pernilla Dahm-Kähler, Niclas Kvarnström
No abstract text is available yet for this article.
February 2018: Fertility and Sterility
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