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Uterus transplantation

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https://www.readbyqxmd.com/read/29450941/hematogenous-dissemination-of-mesenchymal-stem-cells-from-endometriosis
#1
Fei Li, Myles H Alderman, Aya Tal, Ramanaiah Mamillapalli, Alexis Coolidge, Demetra Hufnagel, Zhihao Wang, Elham Neisani, Stephanie Gidicsin, Graciela Krikun, Hugh S Taylor
Endometriosis is ectopic growth of endometrial tissue traditionally thought to arise through retrograde menstruation. We aimed to determine if cells derived from endometriosis could enter vascular circulation and lead to hematogenous dissemination. Experimental endometriosis was established by transplanting endometrial tissue from DsRed+ mice into the peritoneal cavity of DsRed- mice. Using flow cytometry, we identified DsRed+ cells in blood of animals with endometriosis. The circulating donor cells expressed CXCR4 and mesenchymal stem cell (MSC) biomarkers, but not hematopoietic stem cell markers...
February 16, 2018: Stem Cells
https://www.readbyqxmd.com/read/29444715/porcine-wharton-s-jelly-cells-distribute-throughout-the-body-after-intraperitoneal-injection
#2
Kreeson Packthongsuk, Theresa Rathbun, Deryl Troyer, Duane L Davis
BACKGROUND: Wharton's jelly cells (WJCs) have multiple differentiation potentials and are easily harvested in large numbers. WJCs are well tolerated in allogeneic environments and there is a growing list of their therapeutic effects. Most therapies require administering large numbers of cells and this is generally accomplished by intravenous injection. Here, we studied the locations of porcine WJCs in immune-competent, allogeneic hosts after intraperitoneal (IP) injection. METHODS: Male porcine WJCs were administered to female neonatal piglets by IP injection...
February 14, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29433563/therapeutic-effect-of-human-umbilical-cord-derived-mesenchymal-stem-cells-on-injured-rat-endometrium-during-its-chronic-phase
#3
Lu Zhang, Ying Li, Chun-Yi Guan, Shi Tian, Xiao-Dan Lv, Jian-Hui Li, Xu Ma, Hong-Fei Xia
BACKGROUND: Repair deficiency after endometrial injury is an important reason for intra-uterine adhesions, amenorrhea, and infertility in females. Bone marrow-derived mesenchymal stem cell (BMSC) transplantation is effective in repairing the damaged endometrium. However, the possibility of using umbilical cord-derived MSCs (UC-MSCs) to treat endometrial injury is rarely reported. METHODS: Ethanol (95%) was injected into rat uterus to establish a model of endometrial injury...
February 13, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29423621/uterine-transplant-a-risk-to-life-or-a-chance-for-life
#4
Alankrita Taneja, Siddhartha Das, Syed Ather Hussain, Mohammed Madadin, Stany Wilfred Lobo, Huda Fatima, Ritesh G Menezes
Being inherently different from any other lifesaving organ transplant, uterine transplantation does not aim at saving lives but supporting the possibility to generate life. Unlike the kidneys or the liver, the uterus is not specifically a vital organ. Given the non-lifesaving nature of this procedure, questions have been raised about its feasibility. The ethical dilemma revolves around whether it is worth placing two lives at risk related to surgery and immunosuppression, amongst others, to enable a woman with absolute uterine factor infertility to experience the presence of an organ enabling childbirth...
February 8, 2018: Science and Engineering Ethics
https://www.readbyqxmd.com/read/29395094/robotic-assisted-surgery-in-live-donor-uterus-transplantation
#5
EDITORIAL
Mats Brännström, Pernilla Dahm-Kähler, Niclas Kvarnström
No abstract text is available yet for this article.
January 27, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29385880/the-effect-of-antioxidants-on-angiogenesis-in-uterine-transplantation
#6
Tugba Ugurlu, Candan Ozogul, Gulistan Sanem Saribas, Seren Gulsen Gurgen, Seda Nur Akyol, Bahar Kartal
The aim of this study was to investigate the effect of antioxidants on angiogenesis in uterine transplantation. We used 24 female rats equally divided into four groups: Group 1 had the uterus stored in HTK (Histidine-Tryptophan-Ketoglutarate) solution at 4 °C cold storage for 4 h. Group 2 had the uterine tissue stored in HTK solution combined with acetyl L-carnitine (10-8 M) for 4 h at +4 °C. The same procedures with Group 1 and 2 were repeated for 24 h for Groups 3 and 4, respectively. Histological investigation and immunohistochemical analysis were performed...
January 31, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29379666/could-the-female-to-male-transgender-population-be-donor-candidates-for-uterus-transplantation
#7
Murat Api, Ayşen Boza, Mehmet Ceyhan
Objective: To evaluate the eligibility of female-to-male (FtM) transgender people as donor candidates with regard to histologic, surgical, and social aspects. Materials and Methods: In this prospective cohort study, 31 FtM transgender people underwent standard hysterectomy and bilateral salpingo-oophorectomy for gender reassignment upon their request. The pelvic viscera of the transgender people was intraoperatively observed and the histology of the removed uteri were evaluated for fertility capacity and procurement surgery...
December 2017: Turkish journal of obstetrics and gynecology
https://www.readbyqxmd.com/read/29372042/intrauterine-xenotransplantation-of-human-wharton-jelly-derived-mesenchymal-stem-cells-into-the-liver-of-rabbit-fetuses-a-preliminary-study-for-in-vivo-expression-of-the-human-liver-genes
#8
Leila Rezaeian, Seyed Ebrahim Hosseini, Mehdi Dianatpour, Mohammad Amin Edalatmanesh, Nader Tanideh, Asghar Mogheiseh, Amin Tamadon
Objectives: End-stage hepatic failure is a potentially life-threatening condition for which orthotopic liver transplantation is the only effective treatment. However, a shortage of available donor organs for transplantation each year results in the death of many patients waiting for liver transplantation. Xenotransplantation, or the transplantation of cells, tissues, or organs between different species, was proposed as a possible solution to the worldwide shortage of human organs and tissues for transplantation...
January 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29366966/laparoscopic-assisted-uterus-retrieval-from-live-organ-donors-for-uterine-transplant-our-experience-of-two-patients
#9
Shailesh Puntambekar, Milind Telang, Pankaj Kulkarni, Seema Puntambekar, Sanjeev Jadhav, Mangesh Panse, Ravindra Sathe, Nikhil Agarkhedkar, Neeta Warty, Sandesh Kade, Manoj Manchekar, Hirav Parekh, Kajal Parikh, Riddhi Desai, Mehul Mehta, Mihir Chitale, Bhushan Kinholkar, Joy Shankar Jana, Avinash Pare, Abhay Sadre, Swapnil Karnik, Abhay Mane, Giriraj Gandhi, Shailendra Kanade, Uday Phadke
OBJECTIVE: To report the first ever laparoscopic-assisted live donor uterus retrieval in two patients for uterus transplant DESIGN: Case study (Canadian Task Force Classification Level III) SETTING: Galaxy CARE Laparoscopy Institute, Pune, India PATIENT(S): Two patients with AUFI with their mothers as donors. INTERVENTION(S): A twelve member team was formed and approval for transplant was obtained from Institutional Review Board (IRB). Pre transplant, In Vitro Fertilization (IVF) for both patients was done...
January 20, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29364592/live-nondirected-uterus-donors-psychological-characteristics-and-motivation-for-donation
#10
A M Warren, G Testa, T Anthony, G J McKenna, G B Klintmalm, K Wallis, E C Koon, R T Gunby, L Johannesson
Emerging research suggests that uterus transplantation is a viable option for women without a uterus who want to become pregnant and carry a child to term. Currently, no knowledge exists regarding nondirected uterus donors. This study (NCT 02656550) explored the baseline psychological characteristics of nondirected uterus donors at a single study site. Of the 62 potential donors who underwent initial screening, six nondirected donors were chosen and participated in uterus donation. Participants received a comprehensive evaluation, which included clinical history and psychological assessments...
January 24, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29259482/uterus-transplantation-toward-clinical-application-in-japan
#11
REVIEW
Nobuhiko Suganuma, Ayako Hayashi, Iori Kisu, Kouji Banno, Hisako Hara, Makoto Mihara
Background: In recent years, uterus transplantation (UTx) has been applied as the treatment for patients with uterine factor infertility worldwide. Thus, the clinical application of UTx in Japan should be considered through both the history of UTx technology development in the world and future prospects. Methods: Recent information on UTx was collected via a literature survey and the Internet. Results: Basic research using various animals has been done mainly since 2000...
October 2017: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29246556/uterus-transplantation-robotic-surgeon-perspective
#12
Hubert Fornalik, Nicole Fornalik
OBJECTIVE: To study the safety and feasibility of robotic dissection of deep pelvic vessels as applied to the robotic harvesting of a uterus from live transplant donor. DESIGN: Surgical video. SETTING: Gynecologic oncology practice of a tertiary community cancer center. PATIENT(S): Two patients undergoing robotic nerve-sparing radical hysterectomy for International Federation of Gynecology and Obstetrics (FIGO) stage Ib1 cervical cancer...
December 12, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/29228447/ethical-and-medico-legal-remarks-on-uterus-transplantation-may-it-solve-uterine-factor-infertility
#13
S Zaami, E Marinelli, N M di Luca, G Montanari Vergallo
Uterus transplantation was firstly tested with animal trials sixty-five years ago. Despite several successful attempts in human subjects, the different procedures still lay at the experimental stage, in need of further studies and investigations before they can be considered as standard clinical practices. Uterus transplant cannot be regarded as a life-saving procedure, but rather a method to restore woman ability to procreate, when lost, thus improving her quality of life. Uterus transplant is a complex surgical procedure and presents significant health threats...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29221944/living-uterus-donation-and-transplantation-experience-of-interest-and-screening-in-a-single-center-in-the-united-states
#14
Liza Johannesson, Kristin Wallis, E Colin Koon, Greg J McKenna, Tiffany Anthony, Sara G Leffingwell, Goran B Klintmalm, Robert T Gunby, Giuliano Testa
BACKGROUND: Little is known about attitudes toward uterus donation and transplantation in society and the interest of the women the treatment is aimed to assist. OBJECTIVE: This study examined the interest of recipients and living donors in our uterus transplantation program; it describes the screening protocol we developed and the results of the screening and reports demographic data and characteristics of screened candidates. STUDY DESIGN: Initial screening and evaluation included physical examinations by a gynecologist and a transplant surgeon; psychological evaluation; imaging (x-ray, computed tomography, ultrasound); blood tests; immunological testing; viral, bacterial, and fungal testing; drug screen; hormonal testing; Papanicolau smear; urinalysis; and electrocardiogram...
December 6, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29210893/uterus-transplantation-a-rapidly-expanding-field
#15
Mats Brännström, Pernilla Dahm Kähler, Robert Greite, Johan Mölne, César Díaz-García, Stefan G Tullius
No abstract text is available yet for this article.
November 28, 2017: Transplantation
https://www.readbyqxmd.com/read/29177592/hyperandrogenemia-and-ovarian-reserve-in-patients-with-mayer-rokitansky-k%C3%A3-ster-hauser-syndrome-type-1-and-2-potential-influences-on-ovarian-stimulation
#16
Melanie Henes, Ludmila Jurow, Andreas Peter, Birgitt Schoenfisch, Florin Andrei Taran, Markus Huebner, Harald Seeger, Sara Yvonne Brucker, Kristin Katharina Rall
PURPOSE: This study aimed to analyze the hormone profiles, to detect the rate of hyperandrogenemia and to investigate the potential effect of Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) on ovarian reserve, as reflected by the serum Anti-Mullerian hormone (AMH) levels. Clinical implications were analyzed by including our own experiences with three patients after ovarian stimulation in preparation for uterus transplantation. METHODS: Serum samples of 100 patients with MRKHS (50 patients with MRKHS type 1 and 50 with type 2) were analyzed and compared to 50 individually age-matched healthy controls...
November 24, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29157289/vitamin-c-plus-hydrogel-facilitates-bone-marrow-stromal-cell-mediated-endometrium-regeneration-in-rats
#17
Huan Yang, Su Wu, Ran Feng, Junjiu Huang, Lixiang Liu, Feng Liu, Yuqing Chen
BACKGROUND: Intrauterine adhesion (IUA) is a common uterine cavity disease which can be caused by mechanical damage that may eventually lead to infertility and pregnancy abnormalities. Since the effect of therapeutic drugs appears disappointing, cell therapy has emerged as an alternative choice for endometrium regeneration. The aim of this study is to investigate whether the combination of hydrogel Pluronic F-127 (PF-127), Vitamin C (Vc), and a bone marrow stromal cell (BMSC) mixture could be a feasible strategy to improve the endometrial regeneration in a mechanical damage model of IUA in rats...
November 21, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29133152/laparoscopic-assisted-uterus-retrieval-from-live-organ-donors-for-uterine-transplant
#18
Shailesh Puntambekar, Milind Telang, Pankaj Kulkarni, Sanjeev Jadhav, Ravindra Sathe, Neeta Warty, Seema Puntambekar, Sandesh Kade, Mangesh Panse, Nikhil Agarkhedkar, Giriraj Gandhi, Manoj Manchekar, Hirav Parekh, Kajal Parikh, Riddhi Desai, Mehul Mehta, Mihir Chitale, Sambit Nanda
OBJECTIVE: The authors present the first ever laparoscopic assisted uterus retrieval in live donor for uterus transplant. DESIGN: A step-by-step surgical demonstration SETTING: Galaxy CARE Laparoscopy Institute, Pune, India PATIENT(S): Two patients, ages 21 and 26 with Mayer Rokitansky Kuster Hauser (MRKH) syndrome and Ashermann's syndrome respectively, with their mothers as donors. INTERVENTION(S): A Twelve member team was formed. After review of available literature on uterine transplant a protocol was formulated and submitted to the IRB...
November 10, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29077872/allowable-warm-ischemic-time-and-morphological-and-biochemical-changes-in-uterine-ischemia-reperfusion-injury-in-cynomolgus-macaque-a-basic-study-for-uterus-transplantation
#19
Iori Kisu, Kiyoko Umene, Masataka Adachi, Katsura Emoto, Yuya Nogami, Kouji Banno, Iori Itagaki, Ikuo Kawamoto, Takahiro Nakagawa, Hayato Narita, Atsushi Yoshida, Hideaki Tsuchiya, Kazumasa Ogasawara, Daisuke Aoki
No abstract text is available yet for this article.
October 25, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29032587/team-preparation-for-human-uterus-transplantation-autologous-transplantation-in-sheep-model
#20
Evgeny Solomonov, Naama Marcus Braun, Yariv Siman-Tov, Inbar Ben-Shachar
We performed autologous uterus transplantation using the living-sheep donor model for team preparation before human uterine transplantation. Five sequential operations (in 3 ewes) were prospectively conducted. Surgical technique included uterus retrieval, graft preparation, and uterus transplantation. Anastomoses were performed at the level of the external iliac. At 3-week follow-up, the uterus and anastomoses were checked for strictures and thrombosis. Two successful auto-transplantations were made, and one failed because of undeveloped uterine arteries (< 1 mm in diameter)...
December 2017: Clinical Transplantation
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