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https://www.readbyqxmd.com/read/30419632/serum-alanine-aminotransferase-level-as-a-risk-factor-for-coronary-heart-disease-prediction-in-koreans-analysis-of-the-korea-national-health-and-nutrition-examination-survey-v-1-2010-and-v-2-2011
#1
Kiyoung Kim, Dong Sun Kim, Kyu-Nam Kim
Background: The blood level of alanine aminotransferase (ALT) is associated with increased coronary heart disease (CHD) risk. However, its use as an independent factor for CHD risk prediction remains unclear in Asian populations. The purpose of this study was to examine the association between serum ALT levels and CHD risk in Koreans. Methods: This was a cross-sectional study using data from the Korea National Health and Nutrition Examination Survey (V-1, 2010 and V-2, 2011)...
November 13, 2018: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/30419601/should-the-presence-or-extent-of-coronary-artery-disease-be-quantified-in-the-cha2ds2-vasc-score-in-atrial-fibrillation-a-report-from-the-western-denmark-heart-registry
#2
Kamilla Steensig, Kevin K W Olesen, Troels Thim, Jens C Nielsen, Svend E Jensen, Lisette O Jensen, Steen D Kristensen, Hans Erik Bøtker, Gregory Y H Lip, Michael Maeng
BACKGROUND:  Patients with atrial fibrillation (AF) have an increased risk of ischaemic stroke. The risk can be predicted by the CHA2 DS2 -VASc score, in which the vascular component refers to previous myocardial infarction, peripheral artery disease and aortic plaque, whereas coronary artery disease (CAD) is not included. OBJECTIVES:  This article explores whether CAD per se or extent provides independent prognostic information of future stroke among patients with AF...
November 12, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/30419282/cardioprotective-and-anti-apoptotic-effects-of-potentilla-reptans-l-root-via-nrf2-pathway-in-an-isolated-rat-heart-ischemia-reperfusion-model
#3
Ayesheh Enayati, Narguess Yassa, Zohreh Mazaheri, Maryam Rajaei, Mona Pourabouk, Sajjad Ghorghanlu, Salar Basiri, Vahid Khori
BACKGROUND: Previous studies have shown that proanthocyanidins have cardioprotective effects which are mediated via the release of nitric oxide (NO) ultimately resulting in increasing the antioxidant activity. We have investigated to show whether 1) the total extract and ethyl acetate fraction (Et) of Potentilla reptans root have an ischemic preconditioning (IPC) effect, 2) P. reptans has antioxidant and cardioprotective effects mediated by nuclear factor erythroid 2-related factor 2 (Nrf2) pathway and scavenging of reactive oxygen species (ROS), 3) NO, caspase-3 and Bcl-2/Bax are involved in the IPC effect of P...
November 9, 2018: Life Sciences
https://www.readbyqxmd.com/read/30418248/incorporation-of-the-heart-score-into-a-low-risk-chest-pain-pathway-to-safely-decrease-admissions
#4
Brandon R Allen, Grant G Simpson, Ideen Zeinali, Jared T Freitas, Jeffrey J Chapa, Liam J Rawson, Julie A Richter, Thomas F Payton, Joseph Adrian Tyndall
Chest pain can be a challenging complaint to manage in the emergency department. A missed diagnosis can result in significant morbidity or mortality, whereas avoidable testing and hospitalizations can lead to increased health care costs, contribute to hospital crowding, and increase risks to patients. The HEART score is a validated decision aid to identify patients at low risk for acute coronary syndrome who can be safely discharged without admission or objective cardiac testing. In the largest and one of the longest studies to date (N = 31,060; 30 months), we included the HEART score into a larger, newly developed low-risk chest pain decision pathway, using a retrospective observational pre/post study design with the objective of safely lowering admissions...
December 2018: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/30418247/prognostic-utility-of-the-heart-score-in-the-observation-unit
#5
Alexander Michaels, Joseph Gibbs, Sagger Mawri, George Dirani, Lindsey Aurora, Gordon Jacobsen, Richard Nowak, James McCord
The evaluation of individuals with possible acute myocardial infarction (AMI) is time consuming and costly. Risk stratification early during an acute care encounter presents an opportunity for increased delivery of high-value care. We sought to evaluate if the HEART score could be used in the triage of low-risk versus high-risk patients directly home without cardiac testing. Retrospective review of 838 patients placed in an observation unit for evaluation of AMI was done at a single-center, tertiary care teaching hospital...
December 2018: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/30416189/effect-of-statins-on-mortality-in-heart-failure-with-preserved-ejection-fraction-without-coronary-artery-disease-report-from-the-jasper-study
#6
Kyohei Marume, Seiji Takashio, Toshiyuki Nagai, Kenichi Tsujita, Yoshihiko Saito, Tsutomu Yoshikawa, Toshihisa Anzai
BACKGROUND: Statins might be associated with improved survival in patients with heart failure with preserved ejection fraction (HFpEF). The effect of statins in HFpEF without coronary artery disease (CAD), however, remains unclear.Methods and Results:From the JASPER registry, a multicenter, observational, prospective cohort with Japanese patients aged ≥20 years requiring hospitalization with acute HF and LVEF ≥50%, 414 patients without CAD were selected for outcome analysis. Based on prescription of statins at admission, we divided patients into the statin group (n=81) or no statin group (n=333)...
November 9, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/30415653/rate-and-risk-factors-for-aki-after-ct-scans-in-a-cancer-cohort
#7
Sheron Latcha, Andrew J Plodkowski, Junting Zheng, Edgar A Jaimes
AIMS: The proinflammatory milieu in cancer patients may expose them to increased risk for acute kidney injury (AKI) after IV contrast (CON). The aims of this study were to determine: (1) the rates of AKI after CON and noncontrast (NC) CT scans in cancer inpatients, (2) if rates differed among cancer subtypes, and (3) whether recent chemotherapy, comorbid conditions, or nephrotoxins increase AKI after CON. MATERIALS AND METHODS: Retrospective data was collected on adults who had received a CON or NC CT from January 1, 2012 to December 30, 2014...
November 12, 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/30413105/combination-of-plasma-biomarkers-and-clinical-data-for-the-detection-of-myocardial-fibrosis-or-aggravation-of-heart-failure-symptoms-in-heart-failure-with-preserved-ejection-fraction-patients
#8
Cho-Kai Wu, Mao-Yuan M Su, Yi-Fan Wu, Juey-Jen Hwang, Lian-Yu Lin
Background: Heart failure with preserved ejection fraction (HFpEF) is characterized by heart failure symptoms and structural change (including fibrosis). The relationship between novel biomarkers and the above components remains unclear. Methods: Seventy-seven HFpEF patients were recruited. All patients underwent echocardiography with tissue doppler imaging, cardiac magnetic resonance imaging (CMRI), and measurement of plasma inflammatory, remodelling, endothelial function, and heart failure biomarker levels...
November 8, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/30410518/direct-thrombectomy-versus-bridging-for-patients-with-emergent-large-vessel-occlusions
#9
Ronen R Leker, Jose E Cohen, David Tanne, David Orion, Gregory Telman, Guy Raphaeli, Jacob Amsalem, Jonathan Y Streifler, Hen Hallevi, Pavel Gavriliuc, Natan M Bornstein, Anat Horev, Nour Eddine Yaghmour
Background and Aims: Patients with emergent large-vessel occlusion (ELVO) that present earlier than 4 h from onset are usually treated with bridging systemic thrombolysis followed by endovascular thrombectomy (EVT). Whether direct EVT (dEVT) could improve the chances of favorable outcome remains unknown. Methods: Consecutively, prospectively enrolled patients with ELVO presenting within 4 h of onset were entered into a National Acute Stroke Registry of patients undergoing revascularization...
October 2018: Interventional Neurology
https://www.readbyqxmd.com/read/30409707/history-of-atrial-fibrillation-and-trajectory-of-decongestion-in-acute-heart-failure
#10
Ravi B Patel, Muthiah Vaduganathan, Aruna Rikhi, Hrishikesh Chakraborty, Stephen J Greene, Adrian F Hernandez, G Michael Felker, Margaret M Redfield, Javed Butler, Sanjiv J Shah
OBJECTIVES: This study sought to characterize the course of decongestion among patients hospitalized for acute heart failure (AHF) by history of atrial fibrillation (AF) and/or atrial flutter (AFL). BACKGROUND: AF/AFL and chronic heart failure (HF) commonly coexist. Little is known regarding impact of AF/AFL on relief of congestion among patients who develop AHF. METHODS: We pooled patients from 3 randomized trials of AHF conducted within the Heart Failure Network, the DOSE (Diuretic Optimization Strategies) trial, the ROSE (Renal Optimization Strategies) trial, and the CARRESS-HF (Cardiorenal Rescue Study in Acute Decompensated Heart Failure) trial...
November 5, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/30409274/multimarker-approach-to-identify-patients-with-higher-mortality-and-rehospitalization-rate-after-surgical-aortic-valve-replacement-for-aortic-stenosis
#11
Brian R Lindman, Marie-Annick Clavel, Rami Abu-Alhayja'a, Nancy Côté, François Dagenais, Eric Novak, Pierre Voisine, Anthony Poulin, Benoit J Arsenault, Philippe Desmeules, Abdellaziz Dahou, Lionel Taster, Khitam Aldahoun, Yohan Bossé, Patrick Mathieu, Philippe Pibarot
OBJECTIVES: This study sought to evaluate whether a multimarker approach might identify patients with higher mortality and hospitalization rates after aortic valve replacement (AVR) for aortic stenosis (AS). BACKGROUND: The society valve guidelines include accepted triggers for AVR in patients with severe asymptomatic AS, but circulating biomarkers do not have a clear role. METHOD: From a prospective registry of patients undergoing cardiac surgery between 2000 and 2012, 665 treated with surgical AVR (441 isolated) were evaluated...
November 12, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/30408607/effects-of-pre-existing-comorbidities-on-outcomes-in-patients-with-chronic-subdural-hematoma
#12
Hideki Atsumi, Takatoshi Sorimachi, Yumie Honda, Azusa Sunaga, Mitsunori Matsumae
OBJECTIVE: The number of patients with chronic subdural hematoma (CSDH) showing comorbidities and/or impaired activities of daily living (ADL) before the onset of CSDH has increased with the recent aging of society. The purposes of this study were to evaluate ADL worsening by comparing premorbid ADL and ADL at discharge, and to investigate the effects of pre-existing comorbidity-related clinical factors on the outcomes. METHODS: A total of 570 patients with CSDH admitted from 2006 to 2016 were studied retrospectively...
November 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30407958/comparative-analysis-of-emergency-medical-service-provider-workload-during-simulated-out-of-hospital-cardiac-arrest-resuscitation-using-standard-versus-experimental-protocols-and-equipment
#13
Nicholas Asselin, Bryan Choi, Catherine C Pettit, Max Dannecker, Jason T Machan, Derek L Merck, Lisa H Merck, Selim Suner, Kenneth A Williams, Janette Baird, Gregory D Jay, Leo Kobayashi
INTRODUCTION: Protocolized automation of critical, labor-intensive tasks for out-of-hospital cardiac arrest (OHCA) resuscitation may decrease Emergency Medical Services (EMS) provider workload. A simulation-based assessment method incorporating objective and self-reported metrics was developed and used to quantify workloads associated with standard and experimental approaches to OHCA resuscitation. METHODS: Emergency Medical Services-Basic (EMT-B) and advanced life support (ALS) providers were randomized into two-provider mixed-level teams and fitted with heart rate (HR) monitors for continuous HR and energy expenditure (EE) monitoring...
November 7, 2018: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/30407745/myocardial-inflammation-measured-using-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-fdg-pet-ct-is-associated-with-disease-activity-in-rheumatoid-arthritis
#14
Isabelle Amigues, Aylin Tugcu, Cesare Russo, Jon T Giles, Rachelle Morgenstein, Afshin Zartoshti, Christian Schulze, Raul Flores, Sabahat Bokhari, Joan M Bathon
OBJECTIVES: To determine the prevalence and correlates of subclinical myocardial inflammation in rheumatoid arthritis (RA). METHODS: RA patients (n=119) without known cardiovascular disease (CVD) underwent cardiac 18-fluorodeoxyglucose positron emission tomography with computed tomography (FDG PET-CT). Myocardial FDG uptake was assessed visually and quantitatively by standardized uptake values (SUV). Multivariable linear regression was used to assess the associations of patient characteristics with myocardial SUV...
November 8, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/30407304/clinical-characteristics-and-thromboembolic-risk-of-atrial-fibrillation-patients-with-and-without-congestive-heart-failure-results-from-the-cratf-study
#15
Paweł Balsam, Monika Gawałko, Michał Peller, Agata Tymińska, Krzysztof Ozierański, Martyna Zaleska, Katarzyna Żukowska, Katarzyna Szepietowska, Kacper Maciejewski, Marcin Grabowski, Mariusz Borkowski, Łukasz Kołtowski, Anna Praska-Oginska, Inna Zaboyska, Grzegorz Opolski, Janusz Bednarski
Congestive heart failure (CHF) and atrial fibrillation (AF) frequently coexist and are associated with increased risk of cardiovascular events.To compare baseline characteristics, comorbidities and pharmacotherapy in AF patients with concomitant CHF to those without CHF.The study included 3506 real-life AF patients with (37.1%) and without CHF - participants of the multicentre, retrospective MultiCenter expeRience in AFib patients Treated with OAC (CRAFT) trial (NCT02987062).All patients were treated with non-vitamin K antagonist oral anticoagulants (NOAC) or vitamin K antagonists (VKA)...
November 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30407209/are-two-internal-thoracic-grafts-better-than-one-in-patients-with-peripheral-vascular-disease
#16
Nadav Teich, Dmitry Pevni, Rephael Mohr, Nahum Nesher, Amir Kramer, Yosef Paz, Yanai Ben-Gal
BACKGROUND: The use of two bilateral internal thoracic artery grafting (BITA) was shown to lead to survival benefit. However, operators are reluctant to use BITA with peripheral vascular disease (PVD) because of concerns of increased rates of sternal wound infection and lack of studies supporting survival benefit compared with single internal thoracic artery (SITA) grafting. The aim of this study is to compare outcome BITA grafting versus of SITA and vein grafts in PVD patients. PATIENTS AND METHODS: Six hundred and twenty-one PVD patients who underwent BITA between 1996 and 2011 were compared with 372 patients who underwent SITA...
November 6, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/30406891/spirituality-needs-in-chronic-pain-patients-a-cross-sectional-study-in-a-general-hospital-in-malaysia
#17
Kurubaran Ganasegeran, Surajudeen Abiola Abdulrahman, Sami Abdo Radman Al-Dubai, Sin Wan Tham, Muralitharan Perumal
Evidence-based practices that rely upon pain relieving medications and interventional strategies for symptom alleviation in chronic pain survivors have shown modest benefits. The recent emphasis of spiritual care as a new dimension of treatment strategy incorporated within the biopsychosocial model has inspired new hopes to mediate mental and physical health for illness coping. This study aimed to explore the factors associated with spirituality needs among chronic pain patients in a general hospital in Malaysia...
November 8, 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/30406310/prognostic-value-of-a-new-semiquantitative-score-system-for-adenosine-stress-myocardial-perfusion-by-cmr
#18
Sonia Gómez-Revelles, Xavier Rossello, José Díaz-Villanueva, Ignacio López-Lima, Esteban Sciarresi, Mariano Estofán, Francesc Carreras, Sandra Pujadas, Guillem Pons-Lladó
OBJECTIVES: Cardiovascular magnetic resonance (CMR) provides information on myocardial ischemia through stress perfusion studies. In clinical practice, the grading of induced perfusion defects is performed by visual estimation of their extension. The aim of our study is to devise a score of the degree of ischemia and to test its prognostic value. METHODS: Between 2009 and 2011, patients with diagnosed or suspected coronary artery disease underwent stress perfusion CMR...
November 7, 2018: European Radiology
https://www.readbyqxmd.com/read/30404726/combined-testing-of-copeptin-and-high-sensitivity-cardiac-troponin-t-at-presentation-in-comparison-to-other-algorithms-for-rapid-rule-out-of-acute-myocardial-infarction
#19
Matthias Mueller-Hennessen, Bertil Lindahl, Evangelos Giannitsis, Mehrshad Vafaie, Moritz Biener, Alexander C Haushofer, Josef Seier, Michael Christ, Aitor Alquézar-Arbé, Christopher R deFilippi, James McCord, Richard Body, Mauro Panteghini, Tomas Jernberg, Mario Plebani, Franck Verschuren, John K French, Robert H Christenson, Carina Dinkel, Hugo A Katus, Christian Mueller
BACKGROUND: We aimed to directly compare the diagnostic and prognostic performance of a dual maker strategy (DMS) with combined testing of copeptin and high-sensitivity (hs) cardiac troponin T (cTnT) at time of presentation with other algorithms for rapid rule-out of acute myocardial infarction (AMI). METHODS: 922 patients presenting to the emergency department with suspected AMI and available baseline copeptin measurements qualified for the present TRAPID-AMI substudy...
October 26, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30404140/health-literacy-but-not-frailty-predict-self-care-behaviors-in-patients-with-heart-failure
#20
Youn-Jung Son, Dae Keun Shim, Eun Koung Seo, Eun Ji Seo
Heart failure (HF) is a chronic condition requiring continuous self-care. Health literacy is increasingly recognized as a key factor of self-care behaviors in patients with chronic diseases. Recently, frailty in chronic diseases has also been associated with self-care behaviors. However, relationships among health literacy, frailty, and self-care in the HF population are not well understood. Therefore, this cross-sectional study aimed to identify the impact of health literacy and frailty on self-care behaviors in patients with HF...
November 6, 2018: International Journal of Environmental Research and Public Health
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