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https://www.readbyqxmd.com/read/29138391/maternal-impulse-control-disability-and-developmental-disorder-traits-are-risk-factors-for-child-maltreatment
#1
Yoshiyuki Tachibana, Kenji Takehara, Naoko Kakee, Masashi Mikami, Eisuke Inoue, Rintaro Mori, Erika Ota, Tomoe Koizumi, Makiko Okuyama, Takahiko Kubo
Previous work has suggested that maternal developmental disorder traits related to autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) are significantly associated with child maltreatment. However, there may be other important maternal characteristics that contribute to child maltreatment. We hypothesized that maternal impulse control disability may also affect child maltreatment in addition to maternal developmental disorder traits. We aimed to test this hypothesis via a cohort study performed in Tokyo (n = 1,260)...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29119672/self-compassion-and-psychological-distress-in-parents-of-young-people-and-adults-with-intellectual-and-developmental-disabilities
#2
Suzanne Robinson, Richard P Hastings, Jonathan A Weiss, Jaffni Pagavathsing, Yona Lunsky
BACKGROUND: Parenting an individual with intellectual and developmental disabilities (IDD) can be challenging, particularly during adulthood. It is important to better understand ways of supporting families as individuals with IDD age. Self-compassion is a potential internal coping resource for parents, and is strongly linked to positive mental health outcomes, though research has yet to examine it in parents of adults with IDD. METHOD: The current study examines the association between self-compassion and measures of well-being for 56 parents of adults with IDD...
November 9, 2017: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/29118362/deconstructing-atypical-eye-gaze-perception-in-autism-spectrum-disorder
#3
Peter C Pantelis, Daniel P Kennedy
The ability to discern the target of another person's gaze is critical for social and linguistic development, but functions atypically in autism spectrum disorder (ASD). A multi-pronged approach allowed us to deconstruct this complex ability, to uncover the fundamental bases of this impairment. We analyzed performance on a novel gaze perception task with classical psychophysical metrics (precision and accuracy), principal component analysis (in the analysis of spatial biases), and Bayesian computational modeling (in the analysis of individual subjects' use of contextual salience cues)...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29116420/assessing-autism-in-adults-an-evaluation-of-the-developmental-dimensional-and-diagnostic-interview-adult-version-3di-adult
#4
William Mandy, Kiri Clarke, Michele McKenner, Andre Strydom, Jason Crabtree, Meng-Chuan Lai, Carrie Allison, Simon Baron-Cohen, David Skuse
We developed a brief, informant-report interview for assessing autism spectrum conditions (ASC) in adults, called the Developmental, Dimensional and Diagnostic Interview-Adult Version (3Di-Adult); and completed a preliminary evaluation. Informant reports were collected for participants with ASC (n = 39), a non-clinical comparison group (n = 29) and a clinical comparison group (n = 20) who had non-autistic mental health conditions. Mean administration time was 38 min (50 min for ASC). Internal consistency (αs ≥ 0...
November 7, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29116166/multiple-behavior-phenotypes-of-the-fragile-x-syndrome-mouse-model-respond-to-chronic-inhibition-of-phosphodiesterase-4d-pde4d
#5
Mark E Gurney, Patricia Cogram, Robert M Deacon, Christopher Rex, Michael Tranfaglia
Fragile-X syndrome (FXS) patients display intellectual disability and autism spectrum disorder due to silencing of the X-linked, fragile-X mental retardation-1 (FMR1) gene. Dysregulation of cAMP metabolism is a consistent finding in patients and in the mouse and fly FXS models. We therefore explored if BPN14770, a prototypic phosphodiesterase-4D negative allosteric modulator (PDE4D-NAM) in early human clinical trials, might provide therapeutic benefit in the mouse FXS model. Daily treatment of adult male fmr1 C57Bl6 knock-out mice with BPN14770 for 14 days reduced hyperarousal, improved social interaction, and improved natural behaviors such as nesting and marble burying as well as dendritic spine morphology...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29114236/patterns-of-joint-improvisation-in-adults-with-autism-spectrum-disorder
#6
Rachel-Shlomit Brezis, Lior Noy, Tali Alony, Rachel Gotlieb, Rachel Cohen, Yulia Golland, Nava Levit-Binnun
Recent research on autism spectrum disorders (ASDs) suggests that individuals with autism may have a basic deficit in synchronizing with others, and that this difficulty may lead to more complex social and communicative deficits. Here, we examined synchronization during an open-ended joint improvisation (JI) paradigm, called the mirror game (MG). In the MG, two players take turns leading, following, and jointly improvising motion using two handles set on parallel tracks, while their motion tracks are recorded with high temporal and spatial resolution...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29112530/the-prevalence-of-psychiatric-disorders-and-mental-health-services-utilization-by-parents-and-relatives-living-with-individuals-with-autism-spectrum-disorders-in-puerto-rico
#7
Ernesto Magallón-Neri, Dorilyz Vila, Katyana Santiago, Pedro García, Glorisa Canino
Knowledge about prevalence rates of psychiatric disorders and mental health services use among parents and relatives of persons with autism spectrum disorder (ASD) is limited, particularly when referring to epidemiologic samples. The current study is based on an island-wide probabilistic multistage cluster sample of adult individuals (N = 3062) living in Puerto Rico. Results showed a significantly higher rate of attention deficit hyperactivity disorder and serious mental illness in parents (n = 34) or relatives (n = 34) of ASD individuals, as compared with the Puerto Rico adult population as a whole...
November 4, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/29105664/brain-behavior-participant-similarity-networks-among-youth-and-emerging-adults-with-schizophrenia-spectrum-autism-spectrum-or-bipolar-disorder-and-matched-controls
#8
Laura Stefanik, Lauren Erdman, Stephanie H Ameis, George Foussias, Benoit H Mulsant, Tina Behdinan, Anna Goldenberg, Lauren J O'Donnell, Aristotle N Voineskos
There is considerable heterogeneity in social cognitive and neurocognitive performance among people with schizophrenia spectrum disorders (SSD), autism spectrum disorders (ASD), bipolar disorder (BD), and healthy individuals. This study used Similarity Network Fusion (SNF), a novel data-driven approach, to identify participant similarity networks based on relationships among demographic, brain imaging, and behavioral data. T1-weighted and diffusion-weighted magnetic resonance images were obtained for 174 adolescents and young adults (aged 16-35 years) with an SSD (n=51), an ASD without intellectual disability (n=38), euthymic BD (n=34), and healthy controls (n=51)...
November 6, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29104007/perinatal-exposure-to-concentrated-ambient-particulates-results-in-autism-like-behavioral-deficits-in-adult-mice
#9
Jamie S Church, Pamella B Tijerina, Felicity J Emerson, Morgan A Coburn, Jason L Blum, Judith T Zelikoff, Jared J Schwartzer
Exposure to fine ambient particulates (PM2.5) during gestation or neonatally has potent neurotoxic effects. While biological and behavioral data indicate a vulnerability to environmental pollutants across distinct neurodevelopmental windows, the behavioral consequences following exposure across the entire developmental period remain unknown. Moreover, several epidemiological studies support a link between developmental exposure to air pollution and an increased risk of later receiving a diagnosis of autism spectrum disorders (ASD), a neurodevelopmental disorder that persists throughout life...
November 2, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/29099059/actions-of-brain-derived-neurotrophic-factor-and-glucocorticoid-stress-in-neurogenesis
#10
REVIEW
Tadahiro Numakawa, Haruki Odaka, Naoki Adachi
Altered neurogenesis is suggested to be involved in the onset of brain diseases, including mental disorders and neurodegenerative diseases. Neurotrophic factors are well known for their positive effects on the proliferation/differentiation of both embryonic and adult neural stem/progenitor cells (NSCs/NPCs). Especially, brain-derived neurotrophic factor (BDNF) has been extensively investigated because of its roles in the differentiation/maturation of NSCs/NPCs. On the other hand, recent evidence indicates a negative impact of the stress hormone glucocorticoids (GCs) on the cell fate of NSCs/NPCs, which is also related to the pathophysiology of brain diseases, such as depression and autism spectrum disorder...
November 2, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29092799/novel-drosophila-model-for-psychiatric-disorders-including-autism-spectrum-disorder-by-targeting-of-atp-binding-cassette-protein-a
#11
Ibuki Ueoka, Hitoshi Kawashima, Atsushi Konishi, Mikio Aoki, Ryo Tanaka, Hideki Yoshida, Toru Maeda, Mamiko Ozaki, Masamitsu Yamaguchi
Autism spectrum disorder (ASD) is characterized by persistent deficits in social communication and social interactions, as well as restricted, stereotyped patterns of behavior and interests. In addition, alterations in circadian sleep-wake rhythm are common in young children with ASD. Mutations in ATP binding cassette subfamily A member 13 (ABCA13) have been recently identified in a monkey that displays behavior associated with ASD. ABCA13, a member of the ABCA family of proteins, is predicted to transport lipid molecules and is expressed in the human trachea, testis, bone marrow, hippocampus, cortex, and other tissues...
October 29, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29090494/selective-patient-and-public-involvement-the-promise-and-perils-of-pharmaceutical-intervention-for-autism
#12
Ginny Russell, Sandy Starr, Chris Elphick, Raffaele Rodogno, Ilina Singh
BACKGROUND: Guidelines suggest the patient community should be consulted from the outset when designing and implementing basic biomedical research, but such patient communities may include conflicting views. We examined how engagement occurred in one such instance. OBJECTIVE: Our objective was to scrutinize patient and public involvement (PPI) by a pan-European biomedical consortium working to develop drugs to treat autism. We aimed to use this as an example to illustrate how PPI has been utilized in biomedical research...
October 31, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/29089535/language-and-music-phrase-boundary-processing-in-autism-spectrum-disorder-an-erp-study
#13
John DePriest, Anastasia Glushko, Karsten Steinhauer, Stefan Koelsch
Autism spectrum disorder (ASD) is frequently associated with communicative impairment, regardless of intelligence level or mental age. Impairment of prosodic processing in particular is a common feature of ASD. Despite extensive overlap in neural resources involved in prosody and music processing, music perception seems to be spared in this population. The present study is the first to investigate prosodic phrasing in ASD in both language and music, combining event-related brain potential (ERP) and behavioral methods...
October 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29082803/-hold-me-tight-so-i-can-go-it-alone-developmental-themes-for-young-adults-with-autism-spectrum-disorder
#14
Laura Mattys, Ilse Noens, Kris Evers, Dieter Baeyens
Although research shows that young adults with autism spectrum disorder (ASD) struggle with higher rates of depression, anxiety, and other co-occurring psychiatric disorders, their psychological development through emerging adulthood remains understudied. To explore relevant developmental themes for young adults with ASD while subscribing to a social-constructionist epistemology, we interviewed young adults with ASD and their mental health care professionals individually, and organized focus groups with their parents in a multiperspective design...
October 1, 2017: Qualitative Health Research
https://www.readbyqxmd.com/read/29082426/anxiety-disorders-and-obsessive-compulsive-disorder-in-individuals-with-autism-spectrum-disorder
#15
REVIEW
Valentina Postorino, Connor M Kerns, Giacomo Vivanti, Jessica Bradshaw, Martina Siracusano, Luigi Mazzone
PURPOSE OF REVIEW: This review aims to synthesize the most recent research on anxiety disorders and obsessive-compulsive disorder (OCD) in individuals with autism spectrum disorder (ASD) and discuss the relationship between these conditions and challenges for assessment. Furthermore, implications for treatment and future directions are discussed. RECENT FINDINGS: Research suggests that anxiety disorders and OCD are highly prevalent in individuals with ASD. However, the significant overlap of ASD features with anxiety and OCD symptomology makes differential diagnosis of these disorders particularly challenging...
October 30, 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29078024/don-t-ask-me-what-s-the-matter-ask-me-what-matters-acute-mental-health-facility-experiences-of-people-living-with-autism-spectrum-conditions
#16
Paul Maloret, Tricia Scott
BACKGROUND: This qualitative study explored how mental health inpatients with autistic spectrum conditions experience and cope with anxiety when admitted to an acute mental health inpatient facility in the UK. Anxiety is a common characteristic for people who live with autistic spectrum conditions and whilst a plethora of studies on anxiety in this population are published which correlate anxiety with mental health service experience, little is known about the actual triggers of anxiety and its manifestations...
October 27, 2017: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/29075560/deletion-of-fmr1-results-in-sex-specific-changes-in-behavior
#17
Suzanne O Nolan, Conner D Reynolds, Gregory D Smith, Andrew J Holley, Brianna Escobar, Matthew A Chandler, Megan Volquardsen, Taylor Jefferson, Ashvini Pandian, Tileena Smith, Jessica Huebschman, Joaquin N Lugo
OBJECTIVE: In this study, we used a systemic Fmr1 knockout in order to investigate both genotype- and sex-specific differences across multiple measures of sociability, repetitive behaviors, activity levels, anxiety, and fear-related learning and memory. BACKGROUND: Fragile X syndrome is the most common monogenic cause of intellectual disability and autism. Few studies to date have examined sex differences in a mouse model of Fragile X syndrome, though clinical data support the idea of differences in both overall prevalence and phenotype between the sexes...
October 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29072583/self-injury-in-autism-spectrum-disorder-and-intellectual-disability-exploring-the-role-of-reactivity-to-pain-and-sensory-input
#18
REVIEW
Jane Summers, Ali Shahrami, Stefanie Cali, Chantelle D'Mello, Milena Kako, Andjelka Palikucin-Reljin, Melissa Savage, Olivia Shaw, Yona Lunsky
This paper provides information about the prevalence and topography of self-injurious behavior in children and adults with autism spectrum disorder and intellectual disability. Dominant models regarding the etiology of self-injury in this population are reviewed, with a focus on the role of reactivity to pain and sensory input. Neuroimaging studies are presented and suggestions are offered for future research.
October 26, 2017: Brain Sciences
https://www.readbyqxmd.com/read/29072182/social-challenges-of-contemporary-psychiatry
#19
N Bouras
Psychiatry and society are interrelated and the biopsychosocial model continues to dominate the clinical psychiatric practice. Some doubts have been expressed in recent years about the value and the wide acceptance of the biopsychosocial model. Ghaemi (2009)1 considers it to be anti-humanistic and advocates the use of less eclectic, less generic, and less vague alternatives. The fundamental changes that have been witnessed in our times across the spectrum of biology, psychology and sociology have made necessary that a conceptual clarity should prevail...
July 2017: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/29071566/experiences-of-autism-acceptance-and-mental-health-in-autistic-adults
#20
Eilidh Cage, Jessica Di Monaco, Victoria Newell
Mental health difficulties are highly prevalent in individuals on the autism spectrum. The current study examined how experiences and perceptions of autism acceptance could impact on the mental health of autistic adults. 111 adults on the autism spectrum completed an online survey examining their experiences of autism acceptance, along with symptoms of depression, anxiety and stress. Regression analyses showed that autism acceptance from external sources and personal acceptance significantly predicted depression...
October 25, 2017: Journal of Autism and Developmental Disorders
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