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Thomas Sené, Olivier Lidove, Joel Sebbah, Jean-Marc Darondel, Hervé Picard, Laurent Aaron, Olivier Fain, Thierry Zenone, Dominique Joly, Philippe Charron, Jean-Marc Ziza
The incidence and predictive factors of arrhythmias and/or conduction abnormalities (ACAs) requiring cardiac device (CD) implantation are poorly characterized in Fabry disease (FD). The aim of our retrospective study was to determine the prevalence, incidence, and factors associated with ACA requiring CD implantation in a monocentric cohort of patients with confirmed FD who were followed up in a department of internal medicine and reference center for FD.Forty-nine patients (20M, 29F) were included. Nine patients (4M, 5F; 18%) had at least one episode of ACA leading to device therapy...
October 2016: Medicine (Baltimore)
Hoang H Nguyen, Shabana Shahanavaz, George F Van Hare, David T Balzer, Ramzi Nicolas, Jennifer N Avari Silva
BACKGROUND: Percutaneous pulmonary valve implantation (PPVI) is first-line therapy for some congenital heart disease patients with right ventricular outflow tract dysfunction. The hemodynamics improvements after PPVI are well documented, but little is known about its effects on the electrophysiologic substrate. The objective of this study is to assess the short- and medium-term electrophysiologic substrate changes and elucidate postprocedure arrhythmias. METHODS AND RESULTS: A retrospective chart review of patients undergoing PPVI from May 2010 to April 2015 was performed...
September 30, 2016: Journal of the American Heart Association
Javier Jiménez-Candil, Jesús Hernández, Pedro Perdiguero, Ana Martín, José Moríñigo, Loreto Bravo, Olga Durán, Pedro Luis Sánchez
Nonsustained ventricular tachycardias (NSVTs) are frequently observed in patients with left ventricular (LV) dysfunction. The prognostic implications of such NSVTs are conflicting. Our objective was to determine the relation between the burden of NSVT occurring early (within the first 6 months after ICD implant) and prognosis among ICD patients with LV dysfunction. We followed 416 ICD patients (age: 65 ± 11 years; LV ejection fraction: 30 ± 8; ischemic origin: 62%; primary prevention: 63%) with LV dysfunction for 41 ± 27 months...
August 23, 2016: American Journal of Cardiology
Adaya Weissler-Snir, Raymond H Chan, Arnon Adler, Melanie Care, Vijay Chauhan, Michael H Gollob, Tomer Ziv-Baran, Dana Fourey, Waseem Hindieh, Harry Rakowski, Danna A Spears
Nonsustained ventricular tachycardia (NSVT), defined as ≥3 consecutive ventricular beats at ≥120 beats/min lasting <30 seconds, is an independent predictor of sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HC). Current guidelines recommend 24- to 48-hour Holter monitoring as part of SCD risk stratification. We sought to assess the difference in diagnostic yield of 14-day Holter monitoring compared to 24-48 hours for the detection of NSVT and to assess the prevalence and characteristics of NSVT in patients with HC with prolonged monitoring...
October 15, 2016: American Journal of Cardiology
Chin-Yu Lin, Shih-Lin Chang, Fa-Po Chung, Yun-Yu Chen, Yenn-Jiang Lin, Li-Wei Lo, Yu-Feng Hu, Ta-Chuan Tuan, Tze-Fan Chao, Jo-Nan Liao, Yao-Ting Chang, Chung-Hsing Lin, Suresh Allamsetty, Rohit Walia, Abigail Louise D Te, Shinya Yamada, Shuo-Ju Chiang, Hsuan-Ming Tsao, Shih-Ann Chen
BACKGROUND: The impact of non-sustained ventricular tachycardia (NSVT) on the risk of thromboembolic event and clinical outcomes in patients without structural heart disease remains undetermined. This study aimed to evaluate the association between NSVT and clinical outcomes. METHODS: The study population of 5903 patients was culled from the "Registry of 24-hour ECG monitoring at Taipei Veterans General Hospital" (REMOTE database) between January 1, 2002 and December 31, 2004...
2016: PloS One
Joseph E Marine
Nonsustained ventricular tachycardia (NSVT) may trigger concern, particularly in patients with known congestive heart failure, structural heart disease, or prolonged QT interval. When NSVT occurs in patients with normal hearts, it usually has a benign prognosis. Therefore, establishing the presence or absence of structural or inherited heart disease is a critical step in each patient's evaluation. It is important to approach a wide-complex tachycardia in a systematic manner, to ensure correct diagnosis and treatment...
September 2016: Cardiac Electrophysiology Clinics
A McCombe, F Touma, D Jackson, C Canniffe, P Choudhary, L Pressley, D Tanous, Peter J Robinson, D Celermajer
BACKGROUND: Congenitally corrected transposition of the great arteries (ccTGA) is a rare congenital heart disease. There have been only few reports of sudden cardiac death (SCD) in patients with ccTGA and reasonable ventricular function. METHODS: A retrospective review of the medical records of all patients attending our adult congenital heart centre, with known ccTGA. RESULTS: From a database of over 3500 adult patients with congenital heart disease, we identified 39 (∼1%) with ccTGA and 'two-ventricle' circulations...
2016: Open Heart
Leonardo Pippa Gadioli, Carlos Henrique Miranda, Antonio Osvaldo Pintya, Alexandre Baldini de Figueiredo, André Schmidt, Benedito Carlos Maciel, José Antonio Marin-Neto, Marcus Vinicius Simões
BACKGROUND: To investigate the correlation between the extent of myocardial sympathetic denervation and fibrosis and the presence of degrees of severity of ventricular arrhythmias in chronic Chagas cardiomyopathy (CCC). METHODS: Forty-three CCC patients with left ventricular ejection fraction (LVEF) ≥ 35% were divided into three groups: SVT group-presenting Sustained Ventricular Tachycardia (SVT) (n = 15), NSVT group-exhibiting episodes of non-SVT (NSVT) on 24-h Holter monitoring (n = 11), and Control group-exhibiting neither SVT nor episodes of NSVT (n = 17)...
July 5, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Pablo Ávila, François Marcotte, Annie Dore, Lise-Andrée Mercier, Azadeh Shohoudi, François-Pierre Mongeon, Blandine Mondésert, Anna Proietti, Reda Ibrahim, Anita Asgar, Nancy Poirier, Paul Khairy
BACKGROUND: Sudden death of presumed arrhythmic etiology is the leading cause of mortality in adults with tetralogy of Fallot. OBJECTIVES: To assess the impact of exercise on ventricular arrhythmias in adults with tetralogy of Fallot. METHODS: Adults with repaired tetralogy of Fallot were randomized in a 2:1 ratio to an open-label trial of standard care versus 12weeks of supervised combined aerobic/resistance training with continuous Holter monitoring...
September 15, 2016: International Journal of Cardiology
Mikko Jalanko, Mika Tarkiainen, Petri Sipola, Pertti Jääskeläinen, Kirsi Lauerma, Mika Laine, Markku S Nieminen, Markku Laakso, Tiina Heliö, Johanna Kuusisto
OBJECTIVE: We assessed the value of speckle tracking two-dimensional (2D) strain echocardiography (2DSE) measured mechanical dispersion (MD) with other imaging and electrocardiographic parameters in differentiating hypertrophic cardiomyopathy (HCM) patients with and without nonsustained ventricular tachycardia (NSVT) on 24-h ambulatory ECG monitoring. METHODS AND RESULTS: We studied 31 patients with HCM caused by the Finnish founder mutation MYBPC3-Q1061X and 20 control subjects with comprehensive 2DSE echocardiography and cardiac magnetic resonance imaging (CMRI)...
June 1, 2016: Annals of Medicine
Lorenzo Maria Santucci, Fabio Anselmo Saputo, Letizia Verticelli, Ilaria Tamburri, Silvia Placidi, Massimo Stefano Silvetti, Fabrizio Drago
No abstract text is available yet for this article.
August 2016: Pacing and Clinical Electrophysiology: PACE
Aziez Ahmed, John R Phillips
We report the first case of pregnancy in a pediatric patient with catecholiminergic polymorphic ventricular tachycardia (CPVT). Pregnant adolescents with CPVT are at high risk for NSVT and malignant VT during pregnancy, despite antiarrhythmic medication. They may receive multiple implantable cardioverter defibrillator (ICD) therapies. Such patients require close monitoring with special care during the first trimester.
April 2016: Clinical Case Reports
Mary C Niu, Shaine A Morris, Michele Krenek, Caridad M DE LA Uz, Claudia Pedroza, Christina Y Miyake, Jeffrey J Kim, Santiago O Valdés
INTRODUCTION: In pediatric patients with pacemakers implanted for atrioventricular block (AVB), nonsustained ventricular tachycardia (NSVT) detected during routine surveillance is a finding of unknown significance. We sought to describe the incidence of NSVT and determine if there was an association between NSVT and adverse outcomes in these patients. METHODS AND RESULTS: This is a single-center retrospective study of 136 patients (1971-2013) with pacemakers implanted for advanced and complete AVB...
April 2016: Journal of Cardiovascular Electrophysiology
Ting-Yan Zhu, Shu-En Teng, Yan-Yu Chen, Shen-Rong Liu, Su-Rong Meng, Jian Peng
OBJECTIVE: To investigate whether Tpeak-Tend interval (Tp-e) and Tp-e/QT ratio are associated with malignant ventricular arrhythmia in patients with implantable cardioverter-defibrillator (ICD) for primary prevention. METHODS: A cohort of 68 consecutive patients with chronic heart failure undergoing standard ICD for primary prevention indications (NYHA function class II-III, left ventricular ejection fraction ≤35%, systolic cardiomyopathy without prior malignant ventricular arrhythmia) were enrolled in this study...
March 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
Petros Arsenos, George Manis, Konstantinos A Gatzoulis, Polychronis Dilaveris, Theodoros Gialernios, Athanasios Angelis, Achileas Papadopoulos, Erifili Venieri, Athanasios Trikas, Dimitris Tousoulis
BACKGROUND: Deceleration capacity (DC) of heart rate proved an independent mortality predictor in postmyocardial infarction patients. The original method (DCorig) may produce negative values (9% in our analyzed sample). We aimed to improve the method and to investigate if DC also predicts the arrhythmic mortality. METHODS: Time series from 221 heart failure patients was analyzed with DCorig and a new variant, the DCsgn, in which decelerations are characterized based on windows of four consecutive beats and not on anchors...
September 2016: Annals of Noninvasive Electrocardiology
Karthik Viswanathan, Adrian M Suszko, Moloy DAS, Nicholas Jackson, Michael Gollob, Douglas Cameron, Danna Spears, Anna Woo, Harry Rakowski, Mamta Khurana, Vijay S Chauhan
BACKGROUND: Nonsustained ventricular tachycardia (NSVT) detected by ambulatory Holter (Holter NSVT) is a major risk factor for sudden cardiac death in hypertrophic cardiomyopathy (HCM). We hypothesized that the prognostic utility of Holter NSVT in HCM would improve with prolonged monitoring and a higher heart rate cut-off for detection. METHODS: We enrolled 60 patients (44 ± 14 years) with HCM, who had a prophylactic implantable cardioverter defibrillator (ICD)...
July 2016: Pacing and Clinical Electrophysiology: PACE
Matthew D Solomon, Jingrong Yang, Sue Hee Sung, Martha L Livingston, George Sarlas, Judith C Lenane, Alan S Go
BACKGROUND: Ambulatory electrocardiographic (ECG) monitoring is the standard to screen for high-risk arrhythmias. We evaluated the clinical utility of a novel, leadless electrode, single-patient-use ECG monitor that stores up to 14 days of a continuous recording to measure the burden and timing of potentially high-risk arrhythmias. METHODS: We examined data from 122,815 long term continuous ambulatory monitors (iRhythm ZIO® Service, San Francisco) prescribed from 2011 to 2013 and categorized potentially high-risk arrhythmias into two types: (1) ventricular arrhythmias including non-sustained and sustained ventricular tachycardia and (2) bradyarrhythmias including sinus pauses >3 s, atrial fibrillation pauses >5 s, and high-grade heart block (Mobitz Type II or third-degree heart block)...
2016: BMC Cardiovascular Disorders
Alex J A McLELLAN, Andris H Ellims, Sandeep Prabhu, Alex Voskoboinik, Leah M Iles, James L Hare, David M Kaye, Ivan Macciocca, Justin A Mariani, Jonathan M Kalman, Andrew J Taylor, Peter M Kistler
INTRODUCTION: Non-sustained ventricular tachycardia (NSVT) is a risk factor for sudden cardiac death (SCD) in patients with hypertrophic cardiomyopathy (HCM). We aimed to assess whether diffuse ventricular fibrosis on cardiac magnetic resonance (CMR) imaging could be a surrogate marker for ventricular arrhythmias in patients with HCM. METHODS: A total of 100 patients with HCM (mean age 51 ± 13 years, septal wall thickness 20 ± 5 mm) underwent CMR with a 1.5 T scanner to determine the presence of ventricular late gadolinium enhancement (LGE) for focal fibrosis, and post-contrast T1 mapping for diffuse ventricular fibrosis...
May 2016: Journal of Cardiovascular Electrophysiology
An H Bui, Christopher P Cannon, Philippe Gabriel Steg, Robert F Storey, Steen Husted, Jianping Guo, KyungAh Im, Stefan K James, Eric L Michelson, Anders Himmelmann, Claes Held, Christoph Varenhorst, Lars Wallentin, Benjamin M Scirica
BACKGROUND: Nonsustained ventricular tachycardia (NSVT) is common after acute coronary syndrome (ACS) and a marker of increased risk of arrhythmogenic death. However, the prognostic significance of NSVT when evaluated with other contemporary risk markers and at later time points after ACS remains uncertain. METHODS AND RESULTS: In the Platelet Inhibition and Patient Outcomes (PLATO) trial, continuous ECGs were performed during the first 7 days after ACS (n=2866) and repeated for another 7 days at day 30 (n=1991)...
February 2016: Circulation. Arrhythmia and Electrophysiology
Christophe P Teuwen, Tanwier T T K Ramdjan, Marco Götte, Bianca J J M Brundel, Reinder Evertz, Joris W J Vriend, Sander G Molhoek, H G Reinhart Dorman, Jurren M van Opstal, Thelma C Konings, Pepijn van der Voort, Etienne Delacretaz, Nienke J Wolfhagen, Virgilla van Gastel, Peter de Klerk, Dominic A Theuns, Maarten Witsenburg, Jolien W Roos-Hesselink, John K Triedman, Ad J J C Bogers, Natasja M S de Groot
BACKGROUND: Sustained ventricular tachycardia (susVT) and ventricular fibrillation (VF) are observed in adult patients with congenital heart disease (CHD). These dysrhythmias may be preceded by non-sustained ventricular tachycardia (NSVT). The aims of this study are to examine the 1] time course of ventricular tachyarrhythmia (VTA) in a large cohort of patients with various CHDs and 2] the development of susVT/VF after NSVT. METHODS: In this retrospective study, patients with VTA on ECG, 24-hour Holter or ICD-printout or an out-of-hospital-cardiac arrest due to VF were included...
March 1, 2016: International Journal of Cardiology
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