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Transient Global Amnesia

Federica Naldi, Simone Baiardi, Maria Guarino, Luca Spinardi, Fabio Cirignotta, Andrea Stracciari
The acute onset of isolated amnesia is an intriguing challenge for neurologist, because the lack of associated signs can be misleading for diagnosis. The most common cause is transient global amnesia (TGA), a benign condition, but rarely it results from abuse of substance/alcohol or cerebrovascular diseases. In the latter, the brain region involved is the hippocampus. We describe a patient with presenting symptoms of TGA, but affected by an ischemic hippocampal stroke. The computed tomography angiography helped the etiologic diagnosis showing an hemodynamic stenosis of the posterior P2P segment...
December 22, 2016: Neurocase
Bondish Kambaja, Sophie Dupont
The epileptic syndromes, notably the temporal lobe epilepsy, frequently include memory disturbances. These memory disturbances may occur during seizures, i.e. ictal memory disturbances, or between seizures, i.e. interictal memory disturbances. Two atypical clinical epileptic syndromes should be pointed out in the elderly: the transient epileptic amnesia and the epileptic pseudodementia. Both represent potentially reversible memory disturbances and have a treatment based on antiepileptic drugs. Transient epileptic amnesia (TEA) is a subtype of medial temporal lobe epilepsy with late onset...
December 1, 2016: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
Audrey-Anne Fouchard, Karl Mondon, Bertrand De Toffol
Transient epileptic amnesia (TEA) is a sub-type of mesial temporal lobe epilepsy, with amnesic seizures. TEA is characterized by recurrent episodes of amnesia. Diagnostic criteria are available for TEA, and these memory disturbances should not be misdiagnosed with transient global amnesia. The neuropsychological evaluation is normal, however, autobiographical memory impairment is present in 70% of the cases and accelerated long term forgetting in 44%. When a patient complains of memory disturbances, especially autobiographical memory, TEA must be considered especially if there was an amnesic episode and symptoms that suggest temporal epilepsia...
December 7, 2016: La Presse Médicale
Frauke Nees, Martin Griebe, Anne Ebert, Michaela Ruttorf, Benjamin Gerber, Oliver T Wolf, Lothar R Schad, Achim Gass, Kristina Szabo
Transient global amnesia (TGA) is a disorder with reversible anterograde disturbance of explicit memory, frequently preceded by an emotionally or physically stressful event. By using magnetic resonance imaging (MRI) following an episode of TGA, small hippocampal lesions have been observed. Hence it has been postulated that the disorder is caused by the stress-related transient inhibition of memory formation in the hippocampus. In experimental studies, stress has been shown to affect both explicit and implicit learning-the latter defined as learning and memory processes that lack conscious awareness of the information acquired...
2016: Frontiers in Behavioral Neuroscience
Juliane Döhring, Anne Stoldt, Karsten Witt, Robby Schönfeld, Günther Deuschl, Jan Born, Thorsten Bartsch
Learning and the formation of memory are reflected in various memory systems in the human brain such as the hippocampus based declarative memory system and the striatum-cortex based system involved in motor sequence learning. It is a matter of debate how both memory systems interact in humans during learning and consolidation and how this interaction is influenced by sleep. We studied the effect of an acute dysfunction of hippocampal CA1 neurons on the acquisition (on-line condition) and off-line changes of a motor skill in patients with a transient global amnesia (TGA)...
October 24, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Kosuke Yoshida
A 67-year-old right-handed woman experienced a sudden anterograde and retrograde short-term memory deficit that recovered on the next day. Magnetic resonance imaging (MRI) showed a spotty high-intensity lesion in the left putamen in the diffusion-weighted and fluid-attenuated inversion recovery images. Transient global amnesia due to lacunar infarction of the left putamen was diagnosed. Transient global amnesia is characterized by a sudden onset of anterograde amnesia that disappears within 24 hours. The cause of transient global amnesia is still uncertain...
January 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
John Charles Williamson, Andrew J Larner
A 67-year-old woman was diagnosed with transient global amnesia having presented with an abrupt and temporary disruption in her memory function. Her symptom onset came shortly after a visit to her general practitioner where she had performed bedside spirometry. Following symptom resolution, she was discharged home with reassurance.
November 17, 2016: BMJ Case Reports
Luca Pradotto, Laura Orsi, Monica Mencarelli, Marcella Caglio, Danilo Lauro, Alessandra Milesi, Anna Di Blasio, Alessandro Mauro
Despite transient global amnesia is considered unusual in Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and causal relation is still unclear, this report suggests to consider CADASIL in those patients with recurrent transient global amnesia, especially when MRI shows multifocal hyperintensities affecting the cerebral white matter or when it is followed by cognitive decline.
November 2016: Clinical Case Reports
A A Fouchard, J Biberon, K Mondon, B de Toffol
No abstract text is available yet for this article.
December 2016: Seizure: the Journal of the British Epilepsy Association
Young Ho Park, Jeong-Youn Kim, SangHak Yi, Jae-Sung Lim, Jae-Won Jang, Chang-Hwan Im, SangYun Kim
Acute perturbation of the hippocampus, one of the connector hubs in the brain, is a key step in the pathophysiological cascade of transient global amnesia (TGA). We tested the hypothesis that network efficiency, meaning the efficiency of information exchange over a network, is impaired during the acute stage of TGA. Graph theoretical analysis was applied to resting-state EEG data collected from 21 patients with TGA. The EEG data were obtained twice, once during the acute stage (< 24 hours after symptom onset) and once during the resolved stage (> 2 months after symptom onset) of TGA...
2016: PloS One
Md Asiful Islam, Fahmida Alam, Mohammad Amjad Kamal, Kah Keng Wong, Teguh Haryo Sasongko, Siew Hua Gan
Neurological manifestations or disorders associated with central nervous system (CNS) are one of the most common as well as important clinical characteristics of antiphospholipid syndrome (APS). Although in the last updated (2006) classification criteria of APS its neurological manifestations encompassed only transient ischemic attack (TIA) and stroke, diverse 'non-criteria' neurological disorders or manifestations (headache, migraine, bipolar disorder, transverse myelitis, dementia, chorea, epileptic seizures, multiple sclerosis, psychosis, cognitive impairment, Tourette's syndrome, parkinsonism, dystonia, transient global amnesia, obsessive compulsive disorder and leukoencephalopathy) have been observed in APS patients...
September 20, 2016: CNS & Neurological Disorders Drug Targets
Yeonsil Moon, Jeeyoung Oh, Kyoung Ja Kwon, Seol-Heui Han
Transient global amnesia is a well-described clinical syndrome; however, the pathophysiology is perplexing. Structural imaging indicates that punctuate hippocampal lesions are the representative pathophysiology, although functional neuroimaging studies have reported that the various regions comprising the episodic memory network are involved. We hypothesized that the neuronal integrity of the memory network might correlate with amnesia symptoms when there is any insult that can affect the hippocampus. Diffusion tensor images of 5 patients with variable diffusion-weighted imaging findings with or without transient global amnesia symptoms were analyzed...
September 15, 2016: Journal of the Neurological Sciences
Bom Sahn Kim, Sang Soo Cho, Joon Young Choi, Young Hwan Kim
PURPOSE: Transient global amnesia (TGA) is characterized by sudden loss of memory of recent events, transient inability to retain new information, and retrograde amnesia. We investigated the changes of regional cerebral blood flow in patients with TGA shortly after symptom onset and after recovery using Tc-99m-ethyl cysteinate dimer single-photon emission computed tomography (Tc-99m ECD SPECT) and statistical parametric mapping (SPM) analysis. METHODS: Six right-handed patients with TGA were studied using Tc-99m ECD SPECT shortly after symptom onset and after recovery...
September 2016: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
Hongzhou Duan, Liang Li, Yang Zhang, Jiayong Zhang, Ming Chen, Shengde Bao
Introduction. Transient global amnesia (TGA) following angiography is rare, and the pathogenesis has not been illustrated clearly till now. The aim of this research is to explore the pathogenesis of TGA following angiography by analyzing our data and reviewing the literature. Methods. We retrospectively studied 20836 cases with angiography in our hospital between 2007 and 2015 and found 9 cases with TGA following angiography. The data of these 9 cases were analyzed. Results. We found all 9 cases with TGA following neural angiography (5 in 4360) or cardiac angiography (4 in 8817) and no case with TGA following peripheral angiography (0 in 7659)...
2016: BioMed Research International
Jeremy Samuel Faust, Andreea Nemes
Transient global amnesia is a clinically distinct syndrome characterized by the acute inability to form new memories. It can last up to 24 hours. The diagnosis is dependent on eliminating other more serious etiologies including toxic ingestions, acute strokes, complex partial seizures, and central nervous system infections. Transient global amnesia confers no known long-term risks; however, when abnormal signs or symptoms are present, they take precedence and guide the formulation of a differential diagnosis and investigation...
August 2016: Emergency Medicine Practice
David R Spiegel, Aidan L Mccroskey, Branden A Deyerle
Transient global amnesia is a clinical syndrome characterized by the sudden onset of anterograde amnesia, accompanied by repetitive questioning, sometimes with a retrograde component, lasting up to 24 hours, without compromise of other neurologic function. Neuroimaging after an acutetransient global amnesia event often shows transient perturbation of specific hippocampal circuits that are involved in memory processing. Critical clinical distinctions, such as between transient global amnesia and other forms of transient amnesic episodes, as well as important clues to the underlying pathophysiologies are herein reviewed...
March 2016: Innovations in Clinical Neuroscience
Cristiano Correia Bacarin, Jaqueline Godinho, Rúbia Maria Weffort de Oliveira, Makoto Matsushita, Aline Kirie Gohara, Lúcio Cardozo-Filho, Jéssica de Carvalho Lima, Isolde Santos Previdelli, Silvana Regina Melo, Matheus Henrique Dal Molin Ribeiro, Humberto Milani
We reported that fish oil (FO) prevented the loss of spatial memory caused by transient, global cerebral ischemia (TGCI), provided the treatment covered the first days prior to and after ischemia. Continuing these studies, trained rats were subjected to TGCI, and FO was administered for 10days, with a time window of efficacy (TWE) of 4, 8 or 12h post-ischemia. Retrograde memory was assessed up to 43days after TGCI. In another experiment, ischemic rats received FO with a 4- or 12-h TWE, and dendritic density was assessed in the hippocampus and cerebral cortex...
September 15, 2016: Behavioural Brain Research
Jon Foss-Skiftesvik, Agneta Henriette Snoer, Aase Wagner, John Hauerberg
Transient global amnesia is considered a very rare complication of diagnostic cerebral angiography, and has been reported only in a limited number of case reports more than 15 years ago. We describe a patient experiencing transient global amnesia following cerebral digital subtraction angiography. While the condition by definition is self-limiting, its differential diagnoses may cause severe morbidity and/or mortality if left untreated. It is therefore important to build and maintain awareness of transient global amnesia as a possible complication of cerebral angiography...
2014: Radiology case reports
Cristina Tiu, Elena Oana Terecoasă, Nicolae Grecu, Bogdan Dorobăţ, Andreea Nicoleta Marinescu, Ovidiu Alexandru Băjenaru
Transient global amnesia is now considered a very rare complication of cerebral angiography. Various etiological mechanisms have been suggested to account for this complication, but no consensus has been reached yet. This case report documents one of the few reported cases of cerebral angiography-related transient global amnesia associated with magnetic resonance imaging (MRI) evidence of unilateral hippocampal ischemia, most probably as a consequence of a transient reduction in regional hippocampal blood flow...
May 2016: Medicine (Baltimore)
Ophir Keret, Nirit Lev, Tzippy Shochat, Israel Steiner
BACKGROUND AND PURPOSE: Transient global amnesia (TGA) is a stereotypic condition characterized by anterograde and retrograde amnesia that typically resolves within 24 hours. The pathophysiology of TGA is still unclear. We noted that patients hospitalized with TGA tend to appear in seasonal clusters, and decided to investigate this phenomenon. METHODS: Every patient with acute presentation of amnesia at our medical center is hospitalized for observation and evaluation...
April 19, 2016: Journal of Clinical Neurology
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