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Pelvic lymph node dissection

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https://www.readbyqxmd.com/read/28068595/the-impact-of-lymphadenectomy-on-survival-endpoints-in-women-with-early-stage-uterine-endometrioid-carcinoma-a-matched-analysis
#1
Ahmed I Ghanem, Nadia T Khan, Meredith Mahan, Ahmed Ibrahim, Thomas Buekers, Mohamed A Elshaikh
OBJECTIVES: The role of pelvic lymphadenectomy (LA) in women with stage I endometrial carcinoma (EC) is controversial. The objective of this study is to investigate the prognostic impact of LA on survival endpoints in matched cohorts of women with stage I EC solely of endometrioid histology. Survival endpoints included recurrence-free (RFS), disease-specific (DSS) and overall survival (OS). METHODS AND MATERIALS: Patients with FIGO stage I EC who underwent hysterectomy with LA as part of their surgical staging between 1/1990 and 6/2015 were matched to a similar group that underwent hysterectomy without lymphadenectomy (NLA), based on stage, grade and adjuvant management...
December 28, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28068243/sentinel-lymph-node-dissection-to-select-clinically-node-negative-prostate-cancer-patients-for-pelvic-radiation-therapy-effect-on-biochemical-recurrence-and-systemic-progression
#2
Nikolaos Grivas, Esther Wit, Floris Pos, Jeroen de Jong, Erik Vegt, Axel Bex, Kees Hendricksen, Simon Horenblas, Gijs KleinJan, Bas van Rhijn, Henk van der Poel
PURPOSE: To assess the efficacy of robotic-assisted laparoscopic sentinel lymph node (SLN) dissection (SLND) to select those patients with prostate cancer (PCa) who would benefit from additional pelvic external beam radiation therapy and long-term androgen deprivation therapy (ADT). METHODS AND MATERIALS: Radioisotope-guided SLND was performed in 224 clinically node-negative patients scheduled to undergo external beam radiation therapy. Patients with histologically positive SLNs (pN1) were also offered radiation therapy to the pelvic lymph nodes, combined with 3 years of ADT...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28054309/the-effect-of-evolving-strategies-in-the-surgical-management-of-organ-confined-prostate-cancer-comparison-of-data-from-2005-to-2014-in-a-multicenter-setting
#3
Margit Pohle, Ahmed Magheli, Tom Fischer, Carsten Kempkensteffen, Jonas Busch, Hannes Cash, Kurt Miller, Stefan Hinz
INTRODUCTION: The objective of this study was to evaluate changes of patient characteristics and surgical techniques in radical prostatectomy in Germany within the last decade. METHODS: Data from 44 German prostate cancer centers were included in the study. Patients' characteristics (age, initial PSA value), surgical techniques (open vs. minimally invasive approaches), perioperative parameters (operating time, rate of nerve-sparing (NS) radical prostatectomies (RPs), hospitalization time, catheter indwelling time, surgical margin status, number of dissected lymph nodes (LN)), and pathological findings (tumor stage, Gleason score) were analyzed...
January 4, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28049550/gec-estro-acrop-recommendations-for-performing-bladder-sparing-treatment-with-brachytherapy-for-muscle-invasive-bladder-carcinoma
#4
Bradley R Pieters, Elzbieta van der Steen-Banasik, Geert A Smits, Marisol De Brabandere, Alberto Bossi, Erik Van Limbergen
The standard treatment for muscle-invasive bladder cancer (MIBC) is a radical cystectomy with pelvic lymph node dissection with or without neoadjuvant chemotherapy. In selected cases a bladder sparing approach is possible, for example a limited surgical excision combined with external beam radiotherapy and brachytherapy. To perform brachytherapy flexible catheters have to be implanted in the bladder wall. The implantation is done either by the open retropubic approach or the endoscopic surgical approach. The largest experience for brachytherapy is with low-dose rate and pulsed-dose rate, although some short-term experience with high-dose rate is also reported...
December 31, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28040422/pure-but-not-mixed-histologic-variants-are-associated-with-poor-survival-at-radical-cystectomy-in-bladder-cancer-patients
#5
Marco Moschini, Shahrokh F Shariat, Roberta Lucianò, David D'Andrea, Beat Foerster, Mohammad Abufaraj, Marco Bandini, Paolo Dell'Oglio, Rocco Damiano, Andrea Salonia, Francesco Montorsi, Alberto Briganti, Renzo Colombo, Andrea Gallina
PURPOSE: To evaluate the impact of pure and mixed histologic variant versus pure urothelial carcinoma in nonmetastatic bladder cancer (BCa) patients treated with radical cystectomy (RC). PATIENTS AND METHODS: We evaluated data from 1067 patients treated with RC and pelvic lymph node dissection between 1990 and 2013 at a single institution tertiary-care referral center. All specimens were evaluated by dedicated uropathologists. Univariable and multivariable Cox regression analyses tested the impact of the presence of pure and mixed histologic variants versus pure urothelial on recurrence, cancer-specific mortality, and overall mortality after accounting for all available confounders...
December 14, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28035487/application-of-sentinel-lymph-node-dissection-in-gynecological-cancers-results-of-a-survey-among-german-hospitals
#6
Rüdiger Klapdor, Hermann Hertel, Philipp Soergel, Matthias Jentschke, Peter Hillemanns
PURPOSE: Evaluating the application of the sentinel lymph node dissection (SLND) in gynecological cancers among German hospitals. METHODS: Between March and June 2016 an online questionnaire on SLND in gynecologic cancers was sent by email to all German gynecologic cancer centers, all university hospitals and general hospitals for which an email address was available. The survey contained 61 questions regarding the SLND in vulvar, cervical, endometrial and ovarian cancer...
December 29, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28035319/the-role-of-transurethral-resection-in%C3%A2-trimodal-therapy-for-muscle-invasive-bladder-cancer
#7
REVIEW
Christopher M Russell, Amir H Lebastchi, Tudor Borza, Daniel E Spratt, Todd M Morgan
While radical cystectomy (RC) with pelvic lymph node dissection (PLND) represents the accepted gold standard for the treatment of muscle-invasive bladder cancer, this treatment approach is associated with significant morbidity. As such, bladder preservation strategies are often utilized in patients who are either deemed medically unfit due to significant comorbidities or whom decline management with RC and PLND secondary to its associated morbidity. In a select group of patients, meeting strict criteria, bladder preservation approaches may be employed with curative intent...
October 27, 2016: Bladder Cancer
https://www.readbyqxmd.com/read/28024950/detection-and-clinical-significance-of-circulating-tumor-cells-in-patients-undergoing-radical-cystectomy-for-urothelial-bladder-cancer
#8
Vincenzo Pagliarulo, Patrizia Ancona, Tommasangelo Petitti, Annamaria Salerno, Rossana Spadavecchia, Savino Di Stasi, Luigi Cormio, Buscarini Maurizio, Giuseppe Carrieri, Pasquale Ditonno
INTRODUCTION: Estimation of prognosis is patients undergoing radical cystectomy is often unreliable, as occult disease remains undetected by conventional diagnostic tools. The purpose of this study was to evaluate the feasibility and the clinical significance of a polymerase chain reaction assay to detect cytokeratin 7 (CK7) mRNA expression in peripheral blood cells of patients undergoing radical cystectomy for clinically nonmetastatic bladder cancer. PATIENTS AND METHODS: From 2005 to 2009, 59 patients undergoing radical cystectomy and pelvic lymph node dissection were prospectively investigated...
December 1, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28018903/impact-of-lymph-node-burden-on-survival-of-high-risk-prostate-cancer-patients-following-radical-prostatectomy-and-pelvic-lymph-node-dissection
#9
Lisa Moris, Thomas Van den Broeck, Lorenzo Tosco, Anthony Van Baelen, Paolo Gontero, Robert Jeffrey Karnes, Wouter Everaerts, Maarten Albersen, Patrick J Bastian, Piotr Chlosta, Frank Claessens, Felix K Chun, Markus Graefen, Christian Gratzke, Burkhard Kneitz, Giansilvio Marchioro, Rafael Sanchez Salas, Bertrand Tombal, Henk Van Der Poel, Jochen Christoph Walz, Gert De Meerleer, Alberto Bossi, Karin Haustermans, Francesco Montorsi, Hendrik Van Poppel, Martin Spahn, Alberto Briganti, Steven Joniau
AIM: To determine the impact of the extent of lymph node invasion (LNI) on long-term oncological outcomes after radical prostatectomy (RP). MATERIAL AND METHODS: In this retrospective study, we examined the data of 1,249 high-risk, non-metastatic PCa patients treated with RP and pelvic lymph node dissection (PLND) between 1989 and 2011 at eight different tertiary institutions. We fitted univariate and multivariate Cox models to assess independent predictors of cancer-specific survival (CSS) and overall survival (OS)...
2016: Frontiers in Surgery
https://www.readbyqxmd.com/read/28011096/minimally-invasive-radical-hysterectomy-for-cervical-cancer-is-associated-with-reduced-morbidity-and-similar-survival-outcomes-compared-with-laparotomy
#10
Elisabeth Diver, Emily Hinchcliff, Allison Gockley, Alexander Melamed, Leah Contrino, Sarah Feldman, Whitfield Growdon
STUDY OBJECTIVE: In cervical cancer, there are limited randomized trials to indicate whether patient outcomes are equivalent after radical hysterectomy (RH) via minimally invasive (MIS) or traditional laparotomy (XL) approach. The aim of this study was to assess patient outcomes of women with cervical cancer undergoing upfront RH at two large academic institutions to determine if mode of surgery affects patient outcomes. DESIGN: A retrospective cohort study Design classification: Canadian Task Force Classification II-1 SETTING: Two academic medical institutions in the United States from 2000 to 2013 PATIENTS: Women undergoing upfront RH for cervical cancer INTERVENTION: Minimally invasive techniques (laparoscopic and robotic) for RH, as compared with XL MEASUREMENTS AND MAIN RESULTS: 383 women met eligibility requirements...
December 20, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28009151/comparing-conventional-laparoscopic-to-robotic-assisted-extended-pelvic-lymph-node-dissection-in-men-with-intermediate-and-high-risk-prostate-cancer-a-matched-pair-analysis
#11
Simone Albisinni, Fouad Aoun, Dam LE Dinh, Marc Zanaty, Eric Hawaux, Alexandre Peltier, Roland VAN Velthoven
BACKGROUND: In intermediate and high-risk prostate cancer patients, a robotic-assisted approach is increasingly being used for prostatectomy and extended pelvic lymph node dissection (ePLND). This is reducing the number of conventional laparoscopic radical prostatectomies (LR P) and laparoscopic ePLNDs for prostate cancer in Europe. Aim of this study is to compare laparoscopic ePLND to robotic-assisted ePLND in a cohort of patients with intermediate and high risk prostate cancer. METHODS: We performed a matched-pair analysis matching 1:1 70 patients who underwent LRP+ePLND (2004-2009) to 70 who underwent RAR P+ePLND (2010-2014)...
February 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28009147/ten-year-experience-of-robot-assisted-radical-prostatectomy-the-road-from-cherry-picking-to-standard-procedure
#12
Jonas Schiffmann, Alexander Haese, Katharina Boehm, Georg Salomon, Thomas Steuber, Hans Heinzer, Hartwig Huland, Markus Graefen, Pierre I Karakiewicz
BACKGROUND: Patients treated with robot-assisted radical prostatectomy (RARP) are frequently selected according to more favorable characteristics. Such patient selection might decrease according to increasing experience. METHODS: We relied on the Martini Clinic Prostate Cancer Center database and focused on patients treated with RARP between 2004 and 2013. Differences in clinical, pathological and surgical characteristics at RARP over time (2004-2010, 2011-2012 and 2013) were assessed...
February 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28009144/robot-assisted-lymphadenectomy-in-urology-pelvic-retroperitoneal-and-inguinal
#13
Giovannalberto Pini, Surena F Matin, Nazareno Suardi, Mihir Desai, Inderbir Gill, James Porter, Robert J Stein, Rene Sotelo, Franco Gaboardi, Francesco Porpiglia
Lymph node dissection represents an essential surgical step in the treatment of the most commonly treated urological cancers. The introduction of robotic surgery has lead to the possibility of treating these diseases with a minimally invasive surgical approach, but the surgical principles of open surgery need to be carefully respected in order to achieve comparable oncological results. Therefore, the robotic approach to urological cancers must include a carefully performed lymph node dissection when indicated...
February 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27995219/current-technique-and-results-for-extended-pelvic-lymph-node-dissection-during-robot-assisted-radical-prostatectomy
#14
REVIEW
Roger Li, Firas G Petros, Janet B Kukreja, Stephen B Williams, John W Davis
The practice of extended pelvic lymph node dissection (ePLND) remains one of the most controversial topics in the management of clinically localized prostate cancer. Although most urologists agree on its benefit for staging and prognostication, the role of the ePLND in cancer control continues to be debated. The increased perioperative morbidity makes it unpalatable, especially in patients with low likelihood of lymph node disease. With the advent of robotic assisted laparoscopic prostatectomy, many surgeons were slow to adopt ePLND in the robotic setting...
December 2016: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/27987527/development-validation-and-clinical-application-of-pelvic-lymphadenectomy-assessment-and-completion-evaluation-place-intraoperative-assessment-of-lymph-node-dissection-after-robot-assisted-radical-cystectomy-for-bladder-cancer
#15
Ahmed A Hussein, Nobuyuki Hinata, Shiva Dibaj, Paul R May, Justen D Kozlowski, Hassan Abol-Enein, Ronney Abaza, Daniel Eun, Shamim Khan, James L Mohler, Piyush Agrawal, Kamal Pohar, Richard Sarle, Ronald Boris, Sridhar S Mane, Alan Hutson, Khurshid A Guru
OBJECTIVES: To develop a scoring tool, Pelvic Lymphadenectomy Appropriateness and Completion Evaluation (PLACE), to assess the intraoperative completeness and appropriateness of pelvic lymph node dissection (PLND) following robot-assisted radical cystectomy (RARC). METHODS: A panel of 11 open and robotic surgeons developed the content and structure of PLACE. The PLND template was divided into 3 zones. Twenty-one de-identified videos of bilateral robot-assisted PLND were assessed by the 11 experts using PLACE to determine inter-rater reliability (IRR)...
December 17, 2016: BJU International
https://www.readbyqxmd.com/read/27981731/robotic-salvage-retroperitoneal-and-pelvic-lymph-node-dissection-for-node-only-recurrent-prostate-cancer-technique-and-initial-series
#16
Andre Luis de Castro Abreu, Carlos E S Fay, Daniel Park, David Quinn, Tanya Dorff, John Carpten, Peter Kuhn, Parkash Gill, Fabio Almeida, Inderbir S Gill
OBJECTIVES: To describe the technique of robotic high-extended salvage retroperitoneal and pelvic lymphadenectomy (sRPLND+PLND) for 'node-only' recurrent prostate cancer. MATERIALS AND METHODS: Ten patients underwent robotic sRPLND+PLND (09/2015-03/2016) for 'node-only' recurrent prostate cancer, as identified by carbon-11 acetate PET/CT imaging. Our anatomic template extends from bilateral renal artery/vein cranially up to Cloquet's node caudally, completely excising lymphatic-fatty tissue from aorto-caval and iliac vascular trees; RPLND precedes PLND...
December 15, 2016: BJU International
https://www.readbyqxmd.com/read/27980085/the-feasibility-and-effectiveness-of-robot-assisted-radical-cystectomy-after-neoadjuvant-chemotherapy-in-patients-with-muscle-invasive-bladder-cancer
#17
Takuya Koie, Chikara Ohyama, Hayato Yamamoto, Atsushi Imai, Shingo Hatakeyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Tohru Yoneyama, Yuki Tobisawa, Atsushi Yamauchi, Toru Shimazui, Mikinobu Ohtani
OBJECTIVES: The aim of this study was to compare 29 muscle-invasive bladder cancer patients who received neoadjuvant chemotherapy (NAC) followed by immediate robot-assisted radical cystectomy (RARC) with those who underwent minimum-incision endoscopic RC (MIE-RC). METHODS: We retrospectively reviewed the charts of 430 consecutive patients who underwent RC and bilateral pelvic node dissection (PLND) between May 1994 and July 2016. Our study focused on patients with MIBC who had histologically confirmed stage T2-T4aN0M0 urothelial carcinoma of the bladder and received NAC prior to surgery...
December 15, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27958385/updated-postoperative-nomogram-incorporating-the-number-of-positive-lymph-nodes-to-predict-disease-recurrence-following-radical-prostatectomy
#18
D P Nguyen, M Kent, A Vilaseca, R B Corradi, N Fossati, D D Sjoberg, N Benfante, J A Eastham, P T Scardino, K A Touijer
BACKGROUND: A significant number of patients with minimal lymph node disease at radical prostatectomy (RP) and pelvic lymph node dissection (PLND) have better than expected long-term outcomes. We explored whether stratification by number of positive nodes enhances our institutional prediction model for biochemical recurrence after RP. METHODS: A total of 7789 patients underwent RP and pelvic lymph node dissection from 1995 to 2012 at a tertiary referral center. We compared two recurrence prediction models: one incorporated lymph node invasion and the other tracked the number of positive nodes...
December 13, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27957426/mesothelial-inclusions-in-pelvic-lymph-nodes-initially-diagnosed-as-metastatic-prostate-cancer-the-utility-of-second-opinions-and-genomic-testing-in-the-setting-of-unexpected-results
#19
Fadi Joudi, Bela S Denes, Carolyn Mies, Alan W Shindel
Benign mesothelial inclusions in pelvic lymph nodes may be mistaken for metastatic disease in the setting of pelvic malignancy. In this case-report a patient with Low-Risk prostate cancer (confirmed by biopsy and genomic testing) underwent radical prostatectomy with pelvic lymph node dissection. The initial pathological diagnosis was organ-confined Gleason 3 + 3 = 6 cancer with metastasis to a pelvic lymph node. Upon review of the pathological specimen and immunohistochemical staining the lymph node tissue concerning for metastatic disease was recharacterized as mesothelial in origin...
January 2017: Urology Case Reports
https://www.readbyqxmd.com/read/27939590/lymph-node-fluorescence-during-robot-assisted-radical-prostatectomy-with-indocyanine-green-prospective-dosing-analysis
#20
Avinash Chennamsetty, Ali Zhumkhawala, Scott B Tobis, Nora Ruel, Clayton S Lau, Jonathan Yamzon, Timothy G Wilson, Bertram E Yuh
OBJECTIVE: To prospectively assess the ideal dosing and the value of fluorescent sentinel lymph node (LN) detection with indocyanine green (ICG) for the detection of LN metastases in intermediate- and high-risk patients undergoing robot-assisted prostatectomy and extended pelvic LN dissection (ePLND). PATIENTS AND METHODS: Twenty patients received transperineal prostatic injections of ICG. Patients were cycled through 5 doses (1.25, 2.5, 3.75, 5, and 7.5 mg) so optimal ICG dosing could be discovered early...
November 16, 2016: Clinical Genitourinary Cancer
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