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Bleron Azizi, Ana Budimir, Blerim Mehmeti, Suzana Jakovljević, Ivona Bago, Elizabeta Gjorgievska, Dragana Gabrić
PURPOSE: The aim of this study was to evaluate the efficacy of photodynamic therapy (PDT) and light-activated disinfection (LAD) against a 3-day-old bacterial suspension prepared from three different bacterial species present on titanium dental implants, and to analyze the possible alterations of the implant surfaces as a result of the PDT and LAD. MATERIALS AND METHODS: The study was conducted on 72 titanium dental implants contaminated with a bacterial suspension prepared from three bacterial species: Prevotella intermedia, Aggregatibacter actinomycetemcomitans, and Porphyromonas gingivalis...
July 2018: International Journal of Oral & Maxillofacial Implants
Şahin Avşar, Ahmet Öz, Aydan Köken Avşar, Adnan Kaya, Edibe Betül Börklü
Clomiphene citrate is a drug that stimulates ovulation and is commonly used in cases of female infertility. Generally, it is recognized as a safe agent for ovulation induction, but rarely, it is associated with life-threatening conditions. A 36-year-old woman who had been prescribed clomiphene citrate for infertility was admitted to the emergency department for chest pain lasting for 2 hours. She had no history of smoking, and she did not have any cardiac risk factor for myocardial infarction (MI). An electrocardiogram performed on admission revealed ST-elevation in the precordial leads...
July 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
Tümer Erdem Güler, Tolga Aksu, Kazım Serhan Özcan, Serdar Bozyel
This report is a description of a rare case of transient ST-segment elevation during cryoballoon application for paroxysmal atrial fibrillation (PAF). A 74-year-old male with symptomatic PAF was referred to the center for ablation. During cryoablation of the left superior pulmonary vein (188 seconds, -48°C), ST-segment elevation in the anterolateral leads was observed suddenly, though without any significant complaint. Upon the increase in the ST segment, the cryoapplication was immediately terminated. Coronary artery angiography was performed less than 5 minutes after balloon deflation and demonstrated coronary slow flow with a corrected Thrombolysis In Myocardial Infarction (TIMI) frame count of 48...
July 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
Madison Young, Andrew Antczak, Amanda Wawak, Gloria Elliott, Susan Trammell
A light-based processing method to create an amorphous trehalose matrix for the stabilization of proteins is discussed. This method has potential applications in the stabilization of protein-based therapeutics and diagnostics. During light-assisted drying (LAD), proteins suspended in a trehalose solution are dehydrated using near-infrared (NIR) laser light. The goal of this study was to determine processing parameters that resulted in fast processing times and low end moisture contents (EMC), while maintaining the functionality of embedded proteins...
July 2018: Journal of Biomedical Optics
Bharathi D Jagadeesan, Kenneth K Liao, Ganesh Raveendran
Complex Coronary artery to Pulmonary artery fistulas (CPFs) can be difficult to manage with embolization or ligation. An 88-year-old woman with exertional angina was found to have a complex precordial CPF, severe Mitral regurgitation, and Pulmonary Hypertension. CPF treatment was recommended prior to minimally invasive mitral valve replacement (to avoid postoperative myocardial ischemia from worsened steal). The CPF was supplied by multiple branches from the LAD and RCA, and formed a complex common varicosity with multiple drainage channels to the pulmonary artery...
July 18, 2018: Catheterization and Cardiovascular Interventions
Yan-Xia Lv, Sen Zhong, Hexin Tang, Bin Luo, Shao-Juan Chen, Long Chen, Fei Zheng, Lei Zhang, Lu Wang, Xing-Yuan Li, Yu-Wen Yan, Ya-Mu Pan, Miao Jiang, You-En Zhang, Lei Wang, Jian-Ye Yang, Ling-Yun Guo, Shi-You Chen, Jia-Ning Wang, Jun-Ming Tang
BACKGROUND/AIMS: Vagus nerve stimulation (VNS) suppresses arrhythmic activity and minimizes cardiomyocyte injury. However, how VNS affects angiogenesis/arteriogenesis in infarcted hearts, is poorly understood. METHODS: Myocardial infarction (MI) was achieved by ligation of the left anterior descending coronary artery (LAD) in rats. 7 days after LAD, stainless-steel wires were looped around the left and right vagal nerve in the neck for vagus nerve stimulation (VNS)...
July 17, 2018: Cellular Physiology and Biochemistry
Bartłomiej Orlik, Krzysztof Milewski, Kamil Derbisz, Michał Jelonek, Patrycja Chrząszcz, Sonia Beil, Adam Młodziankowski, Wojciech Picheta, Piotr P Buszman, Paweł E Buszman
Introduction: Most clinical trials related to bioresorbable vascular scaffold (BVS) technology are limited to a highly selected patient population. Aim: To evaluate early and long-term clinical outcomes of the Absorb everolimus-eluting BVS compared to the everolimus-eluting metallic XIENCE V stent in routine clinical practice. Material and methods: This is a multicenter, retrospective propensity score-matched comparative study, comprising 76 patients treated with a bare metal stents (BMS) and 501 with a XIENCE stent...
2018: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
Xosé R Bustelo, Piero Crespo, Isabel Fernández-Pisonero, Sonia Rodríguez-Fdez
Deregulated RAS signaling is associated with increasing numbers of congenital diseases usually referred to as RASopathies. The spectrum of genes and mutant alleles causing these diseases has been significantly expanded in recent years. This progress has triggered new challenges, including the origin and subsequent selection of the mutations driving these diseases, the specific pathobiological programs triggered by those mutations, the type of correlations that exist between the genotype and the clinical features of patients, and the ancillary genetic factors that influence the severity of the disease in patients...
July 11, 2018: Current Opinion in Cell Biology
Juan Zhang, Fei Xu, Xiao-Bo Liu, Shao-Jie Bi, Qing-Hua Lu
BACKGROUND/AIM: Rho kinase is a downstream effector of Rho GTPase that is known to regulate various pathological processes. The aim of this study was to evaluate the regulation of Rho kinase activity in leukocytes in patients with ischemia/reperfusion (I/R) injury. PATIENTS AND METHODS: We investigated 38 patients with acute ST-segment elevation myocardial infarction (STEMI), 26 patients with atherosclerosis (AS) and 22 normal subjects. All patients underwent coronary angiography (CAG) and all STEMI patients received primary percutaneous coronary intervention (PPCI) of the left anterior descending artery (LAD) within 12 h after chest pain on-set...
July 1, 2018: Perfusion
Yan-Qun Zhang, Fei-Long Zhang, Wei-Wei Wang, Xue-Hai Chen, Jian-Hua Chen, Liang-Long Chen
Background: Paroxysmal atrial fibrillation (PAF) is one of the most common clinical arrhythmias. Although radiofrequency catheter ablation (RFCA) for the treatment of atrial fibrillation has continuously matured and developed in recent years, some patients treated with RFCA continued to have atrial fibrillation recurrence, and the recurrence rate was high. Determining indicators to predict the recurrence of PAF after RFCA is significantly important for improving the surgical success rate and guiding clinical work...
May 2018: Journal of Thoracic Disease
Kahraman Coşansu, Mustafa Tarık Ağaç, Harun Kılıç, Ramazan Akdemir, Hüseyin Gündüz
A circumflex artery originating from an ostium apart from the left main artery is one of the most common coronary artery anomalies. However, a dual origin of the circumflex artery is an extremely rare anomaly. We describe a 55-year-old male patient admitted to our clinic with the diagnosis of unstable angina. Angiography revealed twin circumflex arteries: one from the left main artery and the other from the proximal right coronary artery and a stenotic left anterior descending coronary artery (LAD). The patient was treated with percutaneous coronary intervention on the LAD lesion...
January 2018: Journal of Tehran Heart Center
Islam A Abdelaziz Ali, Prasanna Neelakantan
Light activated disinfection (LAD) is a strategy for optimizing root canal disinfection by using a highly-selective, targeted killing of bacteria using a combination of photosensitizers and light. Over the past decade, numerous in vitro and clinical studies have been performed to demonstrate the effectiveness of this mode of root canal disinfection. While most studies offer an important understanding of the effectiveness of LAD on monospecies biofilms, few have offered credence to the fact that infections of the root canal system are mediated by polymicrobial biofilms...
July 10, 2018: Dentistry journal
Cierra Bruck, Omar Jafar, Jayne Prats, Deepak Bhatt, Zubair Jafar
INTRODUCTION: Not infrequently, patients undergoing dual antiplatelet therapy for a recent cardiac stent develop a need for a non-cardiac surgery. Most of these surgeries can be delayed while the antiplatelet treatment is stopped and normal platelet function returns in order to avoid potential surgical complications and excessive bleeding. However, there are a number of patients who require urgent surgery where the procedure cannot be postponed. To date, no agents have been proven to bridge the patient off dual-antiplatelet therapy...
July 11, 2018: Cardiology and Therapy
Bobby Yanagawa, Subodh Verma, Akshay Bagai, John D Puskas
PURPOSE OF REVIEW: The purpose of this article is to investigate the potential role of fractional flow reserve (FFR) to guide surgical revascularization. RECENT FINDINGS: Coronary artery bypass is planned and executed primarily based on angiographic coronary anatomy. FFR is the most well-established tool for functional assessment of coronary lesions. Randomized trials have demonstrated the benefit of FFR-guided percutaneous coronary intervention (PCI) to determine the ischemic burden of intermediate lesions...
July 9, 2018: Current Opinion in Cardiology
Lingyan Yuan, Lin Qiu, Yong Ye, Jian Wu, Shuchun Wang, Xingxu Wang, Ning Zhou, Yunzeng Zou
Cardiac hypertrophy after myocardial infarction (MI) is an independent risk factor for heart failure. Regression of cardiac hypertrophy has emerged as a promising strategy in the treatment of MI patients. Here, we have been suggested that heat-shock transcription factor 1 (HSF1) is a novel repressor of ischaemia-induced cardiac hypertrophy. Ligation of left anterior descending coronary was used to produce MI in HSF1-deficient heterozygote (KO), HSF1 transgenic (TG) mice and their wild-type (WT) littermates, respectively...
July 11, 2018: Journal of Cellular and Molecular Medicine
Zichang Tan, Jun Wan, Zhen Lei, Ruicong Zhi, Guodong Guo, Stan Zq Li
Different ages are closely related especially among the adjacent ages because aging is a slow and extremely non-stationary process with much randomness. To explore the relationship between the real age and its adjacent ages, an age group-n encoding (AGEn) method is proposed in this paper. In our model, adjacent ages are grouped into the same group and each age corresponds to n groups. The ages grouped into the same group would be regarded as an independent class in the training stage. On this basis, the original age estimation problem can be transformed into a series of binary classification sub-problems...
December 4, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
Ho Yeol Lee, Seung Pil Ham, Yoo Won Choi, Hai-Jin Park
Autoimmune subepidermal bullous diseases (AISBDs) exhibit various clinical presentations, histological appearances, prognoses, and responses to treatment. Many diagnostic techniques, such as direct immunofluorescence (IF), indirect salt-split skin IF, and enzyme-linked immunosorbent assays, are used in the differential diagnoses of AISBDs. However, these techniques require fresh frozen tissue, expensive laboratory equipment, and sophisticated laboratory techniques. The purpose of this study was to evaluate the value of type IV collagen immunohistochemical (IHC) staining for the differential diagnosis of AISBDs...
June 2018: Acta Dermatovenerologica Croatica: ADC
Pankaj Jariwala, Edla Arjun Padma Kumar
Hyper-dominant left anterior descending artery (LAD) is a rare coronary anomaly where LAD continues as a posterior descending artery. It is a rare coronary anomaly and there are only 19 cases reported so far in 17 case reports in the literature. Its involvement during acute coronary syndrome can be fatal as it leads to ischemia/infarction of a larger area of left and/or right ventricular myocardium. Its early recognition and management is essential with a high index of clinical suspicion.
July 2018: Journal of the Saudi Heart Association
Raneem Fallatah, Abdelfatah Elasfar, Osama Amoudi, Mohamed Ajaz, Ibraheem AlHarbi, Reda Abuelatta
To the best of our knowledge, there have not been any reports of total transcatheter approach including stenting of severe coarctation of the aorta (CoA), transcatheter aortic valve replacement (TAVR) for concomitant severe aortic valve stenosis, and percutaneous coronary intervention (PCI) to treat significant coronary artery disease in a single patient. We report a 70-year-old female, who presented with uncontrolled hypertension and acute decompensated heart failure (ADHF) and was found to have severe CoA, severe bicuspid aortic valve (BAV) stenosis, and significant proximal left anterior descending (LAD) coronary artery disease...
July 2018: Journal of the Saudi Heart Association
Miao Liu, Yilu Wang, Qian Zhu, Junyu Zhao, Yao Wang, Man Shang, Minglin Liu, Yanna Wu, Junqiu Song, Yanxia Liu
Microvesicles (MVs) have been shown to be involved in pathophysiology of ischemic heart diseases. However, the underlying mechanisms are still unclear. Here we investigated the effects of MVs derived from ischemic preconditioning (IPC-MVs) on myocardial ischemic/reperfusion (I/R) injury in rats. Myocardial IPC model was elicited by three cycles of ischemia and reperfusion of the left anterior descending (LAD) coronary artery. IPC-MVs from the peripheral blood of the above animal model were isolated by ultracentrifugation and characterized by flow cytometry and transmission electron microscopy...
July 6, 2018: Apoptosis: An International Journal on Programmed Cell Death
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