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Nieroshan Rajarubendra, Fabio Almeida, Zarko Manojlovic, Chisato Ohe, Nariman Ahmadi, Giovanni Cacciamani, Michael Qiu, Andre Abreu, Jie Cai, Gus Miranda, Mariana C Stern, John Carpten, Peter Kuhn, Mahul B Amin, Parkash S Gill, Manju Aron, Inderbir S Gill
PURPOSE: Conventional imaging cannot definitively detect nodal metastases from prostate cancer (PCa). We histologically validated 11-carbon-Acetate (11 C-Acetate) PET/CT for identifying nodal metastases, examining PCa factors that influence detection rates. MATERIALS AND METHODS: Patients with 11 C-Acetate-avid PET/CT imaged pelvic/retroperitoneal lymph nodes underwent high-extended robotic lymphadenectomy. A standardized mapping-template, comprising 8 pre-determined anatomic regions, was dissected during lymphadenectomy, allowing matched, region-based analysis and comparison of imaging and histological data...
September 12, 2018: Journal of Urology
Hainan Chen, Yijian Liu, Qingjun Gui, Xiao Zhu, Lin Zeng, Jun Meng, Jina Qing, Ling Gao, Ampadu O Jackson, Juling Feng, Yi Li, Jing He, Kai Yin
Ghrelin, a peptide hormone produced in the gastrointestinal tract, has recently been found to be associated with the onset of myocardial fibrosis (MF). The exact mechanism, however, remains elusive. This study sought to identify the function and mechanism of ghrelin on MF after acute myocardial infarction (AMI). AMI was established in Spraque-Dawley rats by ligation of the left anterior descending (LAD). Ghrelin or saline was intraperitoneally injected two times per day for 8 weeks after ligation. The weight of heart (mg) and the weight ratio of heart to body (mg/g) as well as the fibrotic area was increased, while serum level of ghrelin was decreased after AMI...
September 12, 2018: Peptides
Ji-Hoon Na, Sohyun Kim, Lucy Youngmin Eun
Timely diagnosis of coronary involvement is paramount in Kawasaki disease (KD) as it can be associated with long-term morbidity. However, echocardiographic measurements of coronary artery dilation in KD are inconsistent and not proficient for all abnormal arteries. The purpose of this study was to investigate more valuable indices and determine their sensitivity and specificity for early diagnosis of coronary involvement in KD. We performed this retrospective study in 218 children. All patients underwent laboratory and echocardiographic evaluations upon admission...
September 14, 2018: Pediatric Cardiology
D Allan Butterfield, Debra Boyd-Kimball
Alzheimer disease (AD) is a progressive neurodegenerative disorder associated with aging and characterized pathologically by the presence of senile plaques, neurofibrillary tangles, and neurite and synapse loss. Amyloid beta-peptide (1-42) [Aβ(1-42)], a major component of senile plaques, is neurotoxic and induces oxidative stress in vitro and in vivo. Redox proteomics has been used to identify proteins oxidatively modified by Aβ(1-42) in vitro and in vivo. In this review, we discuss these proteins in the context of those identified to be oxidatively modified in animal models of AD, and human studies including Familial AD (FAD), Preclinical AD (PCAD), Mild Cognitive Impairment (MCI), Early AD (EAD), Late AD (LAD), Down syndrome (DS) and DS with AD (DS/AD)...
September 14, 2018: Journal of Neurochemistry
Seong Ho Moon, Joung Hun Byun, Jong Woo Kim, Sung Hwan Kim, Ki Nyun Kim, Jae Jun Jung, Dong Hoon Kang, Jun Ho Yang, Jun Young Choi, In Seok Jang, Hyun Oh Park, Chung Eun Lee, Jong Hwa Ahn
BACKGROUND: A wider angle between the left anterior descending coronary artery (LAD) and left circumflex coronary artery (LCX) has been suggested to induce plaque formation in the arterial system via changes in shear stress. However, the relationship between the left main coronary artery (LM)-LAD angle and LAD stenosis has not been investigated. Therefore, we aimed to evaluate the associations between the LM-LAD and LAD-LCX angles and LAD stenosis. METHODS: Coronary computed tomography angiographies (CTAs) of 201 patients with suspected coronary artery disease were analyzed...
2018: PloS One
John C Moscona, Jason D Stencel, Gregory Milligan, Christopher Salmon, Rohit Maini, Paul Katigbak, Qusai Saleh, Ryan Nelson, Sudesh Srivastav, Owen Mogabgab, Rohan Samson, Thierry Le Jemtel
Background: An accurate diagnostic assessment of coronary artery disease is crucial for patients undergoing coronary artery bypass grafting (CABG). Fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) to guide complete revascularization have not been adequately studied in patients prior to CABG. We compared an anatomic to a physiologic assessment of moderate coronary lesions (40-70% stenosis) in patients referred for CABG. Methods: We retrospectively reviewed 109 medical records of patients who underwent CABG at Tulane Medical Center from 2014 to 2016...
August 2018: Annals of Translational Medicine
Kenneth Drinkwater, Andrew Denovan, Neil Dagnall, Andrew Parker
The Australian Sheep-Goat Scale (ASGS) is a commonly used measure of belief in the paranormal. The scale contains items that index extrasensory perception (ESP), psychokinesis (PK), and life after death (LAD). Although, research employs the ASGS as both a general (unidimensional) and factorial (multidimensional) measure, few studies have examined the appropriateness of these solutions. Accordingly, the present paper tested the psychometric integrity of the ASGS via two studies. Study 1 assessed ASGS factorial structure using confirmatory factor analysis...
2018: Frontiers in Psychology
Paul Rogers, John E Fisk, Emma Lowrie
This study examines the extent to which belief in extrasensory perception (ESP), psychokinesis (PK) or life after death (LAD), plus need for cognition (NFC) and faith in intuition (FI), predict the generation of confirmatory conjunction errors. An opportunity sample (n = 261) completed sixteen conjunction problems manipulated across a 2 event type (paranormal vs. non-paranormal) × 2 outcome type (confirmatory vs. disconfirmatory) within subjects design. Three Generalised Linear Mixed Models - one per paranormal belief type - were performed...
September 7, 2018: Consciousness and Cognition
Rajeev Sandal, Kundan Mishra, Aditya Jandial, Deepesh Lad
No abstract text is available yet for this article.
September 8, 2018: BMJ Case Reports
Chun Li, Yi Zhang, Qiyan Wang, Hui Meng, Qian Zhang, Yan Wu, Wei Xiao, Yong Wang, Pengfei Tu
ETHNOPHARMACOLOGICAL RELEVANCE: Dragon's Blood (DB), the red resin of Dracaena cochinchinensis (Lour.) S. C., has been used in traditional Chinese medicine to treat acute myocardial infarction (AMI) for centuries. Evidence indicated that DB may exert cardio-protective effect by inhibiting inflammatory response during myocardial infarction. However, its pharmaceutical mechanism is still to be elucidated. AIM OF THE STUDY: Due to its potential anti-inflammatory effect, Dragon's Blood extract (DBE) was applied on AMI mice model in this study and its mechanism on inflammation via PI3K-AKT-mTOR signaling pathway was to be validated...
September 6, 2018: Journal of Ethnopharmacology
M Winnisch, T M Tiefenboeck, M Steiger, M Komjati, M Hofbauer, R Kdolsky
BACKGROUND: The purpose of this study was to objectively evaluate the clinical functionality of the knee joint 30 years after surgical augmentation of the ACL with the "Kennedy Ligament Augmentation Device ®" (Kennedy LAD®). METHODS: The patient collective consisted of 41 patients with an average age of 59.51 years (±10.18 standard deviation). Included were all patients treated operatively with a Kennedy LAD® augmented reattachment of the ACL at the Department of Trauma Surgery between 1983 and 1985...
September 4, 2018: Knee
Sheila MacDonnell, Lisa M Papazian
This is a case report of a 29-year-old, male applicant for life insurance who was discovered to have an absence of the left main coronary artery (LMCA), with the left anterior descending coronary artery (LAD) and left circumflex coronary artery (LCX) each arising directly from the left sinus of Valsalva. A brief review of several types of coronary artery anatomic variants will be presented.
January 2018: Journal of Insurance Medicine
Shirley Siang Ning Tan, Keng Tat Koh, Lee Len Tiong, Tiong Kiam Ong, Alan Yean Yip Fong
AIM: Recurrent thrombotic events still occur despite dual antiplatelet therapy in patient's post percutaneous coronary intervention (PCI) could be attributed to high on-treatment platelet reactivity. METHODS: A 44-year-old male, who had staged PCI to left anterior descending (LAD) 2 weeks after an anterior MI, with a drug-coated stent was readmitted with new anterior STEMI 35 days later. Coronary angiogram revealed mid-stent thrombus in situ. He had further uncomplicated PCI...
September 7, 2018: Pharmacogenomics
Quratulain Fatima Masood, Ali Asad, Syed Maaz Tariq, Saad Javaid, Muhammad H Khalil, Fiaz Hussain
Spontaneous coronary artery dissection (SCAD) is one of the rarest causes of acute coronary syndromes, which include myocardial infarction (MI), stable and unstable angina, cardiogenic shock, and sudden death. The course of the disease, its etiology, prevalence, prognosis, and treatment remain ill-defined. Adding to the complexity is the fact that patients may lack typical risk factors for coronary heart disease. Herein, we report a case of a 42-year-old woman with vitamin B12 deficiency, who presented with chest pain; electrocardiography (ECG) findings were consistent with the acute anterior wall MI...
July 1, 2018: Curēus
Sho Kusadokoro, Koichi Adachi, Mio Shinshi, Daijiro Hori, Hiroko Nakata, Atsushi Yamaguchi
Approximately 40% of the patients with aortic aneurysm have coronary artery disease(CAD), which is an important factor contributing to early mortality associated with aneurysm surgery. Combined coronary artery bypass grafting (CABG)and aortic aneurysm repair of the ascending aorta to the aortic arch is often performed through a median sternotomy due to a good surgical exposure. However, treatment strategy of thoraco-abdominal aortic aneurysm(TAAA) combined with CAD is often controversial. We report a successful case of a 69-year-old man who underwent TAAA repair and CABG through a left thoracotomy...
August 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
Takeshi Ikuta, Noriaki Kishimoto, Hirofumi Fujii, Eiji Kimura, Yoshihiro Shimizu
Ventricular septal rupture(VSR) after acute myocardial infarction(AMI) is a rare and serious complication that is associated with extremely high mortality. Delayed VSR is particularly uncommon and is difficult to diagnose and treat. A 68-year-old man presented with dyspnea on effort. Coronary angiography revealed subtotal occlusion of the right coronary artery(RCA) with collateral circulation to the chronically and totally occluded left anterior descending artery (LAD). Elective stenting of the RCA was successfully performed for a recent MI of the RCA, while percutaneous coronary intervention(PCI) in the LAD ended in failure...
September 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
Deanna K Olney, Jef Leroy, Lilia Bliznashka, Marie T Ruel
Background: Food-assisted maternal and child health and nutrition (FA-MCHN) programs may foster child growth during the first 1000 d (pregnancy and the first 2 y of a child's life), but evidence is scant. Objective: We evaluated the impact of an FA-MCHN program, PROCOMIDA, on linear growth (stunting [length-for-age z score (LAZ) < -2] and length-for-age difference [LAD]) among children aged 1-24 mo. PROCOMIDA was implemented in Guatemala by Mercy Corps and was available to beneficiaries throughout the first 1000 d...
September 1, 2018: Journal of Nutrition
Jessica L Bloom, Jeffrey R Darst, Lori Prok, Jennifer B Soep
BACKGROUND: Henoch-Schonlein Purpura (HSP) is one of the most common vasculitides of childhood, with 10-20 cases per 100,000 children. It frequently occurs following an infectious trigger and involves IgA and C3 deposition in small vessel walls. HSP is characterized by palpable purpura plus IgA deposition on biopsy, arthritis/arthralgia, renal involvement (hematuria and/or proteinuria), and/or abdominal pain. It is not generally recognized as a cause of dilated coronary arteries. CASE PRESENTATION: We describe the first reported case of HSP presenting with dilated coronary arteries...
September 4, 2018: Pediatric Rheumatology Online Journal
C-C Wang, B-B Shang, C-W Yang, Y-F Liu, X-D Li, S-Y Wang
OBJECTIVE: To explore the role of microRNA-326 in myocardial fibrosis after myocardial infarction (MI) and its underlying mechanism. MATERIALS AND METHODS: MI rat model was constructed via left anterior descending artery (LAD) ligation. Infarct tissues, infarct border zone tissues and remote zone tissues were harvested at postoperative 1st, 2nd, and 4th week, respectively. The mRNA levels of microRNA-325, collagen I, fibronectin, and transforming growth factor-β1 (TGF-β1) in the above tissues were detected by qRT-PCR (quantitative Real-time polymerase chain reaction)...
August 2018: European Review for Medical and Pharmacological Sciences
John J Wang, Olle Pahlm, James W Warren, John L Sapp, B Milan Horáček
BACKGROUND: Criteria for electrocardiographic detection of acute myocardial ischemia recommended by the Consensus Document of ESC/ACCF/AHA/WHF consist of two parts: The ST elevation myocardial infarction (STEMI) criteria based on ST elevation (ST↑) in 10 pairs of contiguous leads and the other on ST depression (ST↓) in the same 10 contiguous pairs. Our aim was to assess sensitivity (SE) and specificity (SP) of these criteria-and to seek their possible improvements-in three databases of 12‑lead ECGs...
August 13, 2018: Journal of Electrocardiology
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