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Hoon Choi, David Harvey, Yi Ding, Nien-Hwa Linda Wang
A constant-pattern design method for separating ternary mixtures using ligand-assisted displacement chromatography was developed for non-ideal systems. The general correlation for the minimum column length required to achieve the constant-pattern state for binary separations from our previous study was extended to ternary separations. Additionally, an equation for the yield of a target component as a function of key dimensionless groups was derived based on the constant-pattern mass transfer zone lengths. The column length and operating velocity solved from the two equations ensured the yields and the constant-pattern state for the target components...
September 29, 2018: Journal of Chromatography. A
Hyeonyong Hae, Soo-Jin Kang, Won-Jang Kim, So-Yeon Choi, June-Goo Lee, Youngoh Bae, Hyungjoo Cho, Dong Hyun Yang, Joon-Won Kang, Tae-Hwan Lim, Cheol Hyun Lee, Do-Yoon Kang, Pil Hyung Lee, Jung-Min Ahn, Duk-Woo Park, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park
BACKGROUND: Invasive fractional flow reserve (FFR) is a standard tool for identifying ischemia-producing coronary stenosis. However, in clinical practice, over 70% of treatment decisions still rely on visual estimation of angiographic stenosis, which has limited accuracy (about 60%-65%) for the prediction of FFR < 0.80. One of the reasons for the visual-functional mismatch is that myocardial ischemia can be affected by the supplied myocardial size, which is not always evident by coronary angiography...
November 2018: PLoS Medicine
Giorgio Quadri, Enrico Cerrato, Cristina Rolfo, Ferdinando Varbella
A young woman admitted with a diagnosis of NSTE-ACS underwent coronary angiography which showed LAD spontaneous coronary artery dissection treated with magnesium-made bioresorbable scaffold. We report 1-year angiographic and OCT findings.
November 12, 2018: Catheterization and Cardiovascular Interventions
Zhiling Qiu, Yuanhui Hu, Yanting Geng, Huaqin Wu, Rongqiang Bo, Jingjing Shi, Jiuchong Wang, Huan Wang
Heart failure caused by myocardial infarction is a common cardiovascular disease with high mortality rate. Myocardial mitophagy is involved in the process of occurrence and development of heart failure. In this study, we aimed to investigate the effects of Xin Fu Kang (XFK) oral liquid on myocardial mitophagy in a rat model of advanced heart failure. The rat model of advanced heart failure was established by ligating the left anterior descending (LAD) artery for eight weeks. Captopril and XFK were given by gavage separately...
2018: American Journal of Translational Research
Jaywant Nawale, Rajendra Chavan, Meghav Shah, Digvijay Nalawade, Nikhil Borikar, Ajay Chaurasia
Congenital coronary anomalies are rare and reported to occur in 0.64-1.3% of patients undergoing coronary angiography. The dual left anterior descending coronary artery (LAD) is a rare coronary anomaly defined as the presence of two LADs in the anterior interventricular sulcus (AIVS). It consists of a short LAD that ends high in the AIVS and a longer LAD that enters the distal AIVS and feeds apex. Percutaneous interventions are even more uncommon in dual LAD especially Type V LAD. Thus we describe an interesting case of percutaneous transluminal coronary angioplasty (PTCA) with stenting to Type V dual LAD in a patient with chronic stable angina who was refractory to maximal anti-anginal medications...
November 2018: Journal of Cardiology Cases
Baruch Wolach, Ronit Gavrieli, Ofir Wolach, Tal Stauber, Omar Abuzaitoun, Amir Kuperman, Yaakov Amir, Polina Stepensky, Raz Somech, Amos Etzioni
Leukocyte Adhesion Deficiency (LAD) is a rare, innate autosomal-recessive immunodeficiency with 3 subtypes. Twenty-nine patients with LADs were diagnosed and treated in Israeli Medical Centers and in the Palestinian Authority. We discuss the phenotypic, genotypic and biochemical features of LAD-I, -II and -III diagnosed during the neonatal period and early infancy in 18, 6 and 5 patients, respectively. Consanguinity was frequent. Common features were severe infections of variable etiology, excessive leukocytosis and delayed umbilical cord detachment...
November 9, 2018: European Journal of Clinical Investigation
Emrah Ermis, Serkan Kahraman, Hakan Ucar, Sinem Ozbay Ozyılmaz, Samir Allahverdiyev
Simultaneous multivessel epicardial coronary artery thrombosis is an uncommon finding in acute ST-segment elevation myocardial infarction (STEMI). It generally leads to cardiogenic shock and sudden cardiac death in the hospital. We report a 42-year-old male patient presenting with acute anterior STEMI with triple coronary artery thrombosis. An emergency coronary angiogram showed total occlusion of the left anterior descending artery (LAD) with thrombus formation. At the same time, thrombus formations were also seen in the circumflex artery (CXA), the second obtuse marginal (OM2) branch, and the distal right coronary artery (RCA)...
December 2018: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
Xiao He, Meng-Wei Yao, Ming Zhu, Dong-Lan Liang, Wei Guo, Yi Yang, Rong-Seng Zhao, Ting-Ting Ren, Xiang Ao, Wei Wang, Chun-Yu Zeng, Hua-Ping Liang, Dong-Po Jiang, Jian Yu, Xiang Xu
BACKGROUND: Cardiovascular complications, especially myocardial infarctions (MIs), are the leading mortality cause in diabetic patients. The transplantation of stem cells into damaged hearts has had considerable success as a treatment for MI, although whether antidiabetic drugs affect the therapeutic efficacy of stem cell transplantation is still unknown. This study aims to understand whether and how metformin, one of the first-line drugs used to treat type 2 diabetes mellitus (T2 DM), induces mesenchymal stromal cell (MSC) apoptosis and dampens their cardioprotective effect after transplantation into infarcted hearts...
November 8, 2018: Stem Cell Research & Therapy
Hui-Ping Zhang, Xue Yu, Fu-Sui Ji, Fu-Cheng Sun
RATIONALE: The safety and efficacy of drug-coated balloon (DCB) technology have primarily been proven in the treatment of coronary in-stent restenosis. Whereas increasing evidences show that DCB use was feasible in certain de novo coronary lesions. In 2012, Vassilev reported the 1st case in which a coronary aneurysm formed after a DCB was used to treat drug-eluting stent (DES) restenosis. To date, limited information has been reported on coronary artery aneurysm (CAA) development following DCB treatment of de novo lesions...
November 2018: Medicine (Baltimore)
Hassan Tahir, Sajjad Ahmad, Muhammad U Awan, Bassam Omar, Joey Glass, Jason Cole
Congenital coronary anomalies are uncommon and are mostly asymptomatic; however, patients may have symptoms depending on the origin and course of anomalous artery. Very rarely, coronary anomalies can also lead to life-threatening complications especially in young athletes. A malignant course of the left main (LM) or left anterior descending (LAD) artery between aorta and pulmonary artery is considered the most significant risk factor for such complications. Various noninvasive tests are available to evaluate myocardial ischemia due to anomalous coronary artery...
August 28, 2018: Curēus
Yosuke Murase, Yasuya Inden, Hajime Imai, Seifuku Kyo, Satoshi Yanagisawa, Aya Fujii, Yusuke Sakamoto, Toshiro Tomomatsu, Toyoaki Murohara
Early recurrence of atrial arrhythmia (ERAA) after ablation frequently occurs, but there is limited evidence about ERAA-timing. This study aimed to investigate the association between ERAA-timing and late recurrence. We retrospectively investigated 332 patients who underwent PVI for paroxysmal atrial fibrillation at Nagoya University Hospital and Komaki City Hospital. Seventy-six patients (23%) had ERAA. The cutoff value of the first ERAA for late recurrence was set as 3 days, with a specificity of 77% and sensitivity of 43%...
November 2, 2018: Heart and Vessels
Alexey V Pindyurin, Artem A Ilyin, Anton V Ivankin, Mikhail V Tselebrovsky, Valentina V Nenasheva, Elena A Mikhaleva, Ludo Pagie, Bas van Steensel, Yuri Y Shevelyov
BACKGROUND: In most mammalian cell lines, chromatin located at the nuclear periphery is represented by condensed heterochromatin, as evidenced by microscopy observations and DamID mapping of lamina-associated domains (LADs) enriched in dimethylated Lys9 of histone H3 (H3K9me2). However, in Kc167 cell culture, the only Drosophilla cell type where LADs have previously been mapped, they are neither H3K9me2-enriched nor overlapped with the domains of heterochromatin protein 1a (HP1a). RESULTS: Here, using cell type-specific DamID we mapped genome-wide LADs, HP1a and Polycomb (Pc) domains from the central brain, Repo-positive glia, Elav-positive neurons and the fat body of Drosophila third instar larvae...
November 1, 2018: Epigenetics & Chromatin
Uday Yanamandra, Kamal Kant Sahu, Parathan Karunakaran, Deeksha Katoch, Nidhi Jain, Alka Khadwal, Gaurav Prakash, Deepesh Lad, Shano Naseem, Neelam Varma, Subhash Varma, Pankaj Malhotra
The data on Adolescent and Young Adult Chronic Myeloid Leukemia (AYA-CML) from the Indian subcontinent are scarce. We studied characteristics of AYA-CML through a retrospective analysis of 1950 CML patients registered to a tertiary care hospital in Northern India. AYA-CML represented 22.1% of all CML patients, with cumulative overall survival (OS) of 84%, and 1 and 8 years OS of 94.2% and 74.2%, respectively. Of all cases, 8.91% patients had advanced disease at the time of diagnosis, and 13.95% had myelofibrosis in the diagnostic marrow, 79...
November 1, 2018: Journal of Adolescent and Young Adult Oncology
Ashkan Javadzadegan
Computational fluid dynamics (CFD) modeling of myocardial bridging (MB) remains challenging due to its dynamic and phasic nature. This study aims to develop a patientspecific CFD model of MB. There were two parts to this study. The first part consisted of developing an in silico model of the left anterior descending (LAD) coronary artery of a patient with MB. In this regard, a moving-boundary CFD algorithm was developed to simulate the patient-specific muscle compression caused by MB. A second simulation was also performed with the bridge artificially removed to determine the hemodynamics in the same vessel in the absence of MB...
November 1, 2018: Journal of Biomechanical Engineering
Ajith Ananthakrishna Pillai, Sasinthar Rangasamy
We report a case of severe negative remodelling at the ostium of septal LAD artery. We deferred stenting to avoid the risk of rupture of the vessel and stent fracture.
October 31, 2018: International Journal of Cardiovascular Imaging
Marina Piccinelli, Sang-Geon Cho, Ernest V Garcia, Erick Alexanderson, Joo Myung Lee, C David Cooke, Nikhil Goyal, Mauricio Santos Sanchez, Russel D Folks, Zhengjia Chen, John Votaw, Bon-Kwon Koo, Hee-Seung Bom
OBJECTIVES: The goal of the present work is to present a novel methodology for the extraction of MBF, MFR and RFR along coronary arteries by means of multimodality image fusion of dynamic PET and CCTA images. BACKGROUND: FFR is the reference standard to identify flow-limiting lesions, but its invasiveness limits broad application. New noninvasive methodologies are warranted to stratify patients and guide treatment. METHODS: A group of 16 low-risk CAD subjects who underwent both 13 NH3 PET and CCTA were analyzed...
October 29, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Yunxia An, Qianqian Zhang, Xiaoliang Li, Zheng Wang, Ying Li, Xueyi Tang
PURPOSE: In this study, we aimed to identify the key pathways and hub genes in lung adenocarcinoma (LAD)1 through bioinformatics analysis and to identify the miRNAs that targeted the selected hub gene. The present study was conducted to explore the effect of the hub gene KIBRA, the Hippo signaling pathway and miR-21 on LAD progression. METHODS: Through gene set enrichment analysis (GSEA), the enriched KEGG pathways involved in LAD were identified. Weighted correlation network analysis (WGCNA) was employed to screen out hub genes...
October 19, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Xuan Li, Jia Liu, Haiyan Hu, Shaoxin Lu, Qingguo Lu, Nanhu Quan, Thomas Rousselle, Mulchand S Patel, Ji Li
Dichloroacetate (DCA), an inhibitor of pyruvate dehydrogenase kinase (PDK), regulates substrate metabolism in the heart. AMP-activated protein kinase (AMPK) is an age-related energy sensor that protects the heart from ischemic injury. This study aims to investigate whether DCA can protect the heart from ischemic injury through the AMPK signaling pathway. Young (3-4 months) and aged (20-24 months) male C57BL/6J mice were subjected to ligation of the left anterior descending coronary artery (LAD) for an in vivo ischemic model...
October 29, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
Aditya Jandial, Kundan Mishra, Pranab Dey, Deepak Goni, Mohd Umair, Deepesh Lad, Gaurav Prakash, Alka Khadwal, Neelam Varma, Pankaj Malhotra
Diffuse large B-cell lymphoma (DLBCL) is the commonest sub-type of non-Hodgkin lymphoma. However, lung consolidation is a rare presentation of DLBCL. Moreover, in view of poor general condition, it poses clinical dilemma of when to start chemotherapy and whether chemotherapy should be given at full dose or truncated doses till improvement in general condition. A 48-years-old lady was admitted with complaints of non-productive cough for 2 months duration. She was febrile and hypoxemic requiring oxygen supplementation...
October 2018: Indian Journal of Hematology & Blood Transfusion
Kennosuke Yamashita, Myong Hwa Yamamoto, Wataru Igawa, Morio Ono, Takehiko Kido, Seitarou Ebara, Toshitaka Okabe, Shigeo Saito, Kisaki Amemiya, Naoei Isomura, Hiroshi Araki, Masahiko Ochiai
The relationship between epicardial adipose tissue volume (EATV) and plaque vulnerability in non-culprit coronary lesions is not clearly understood.Fifty-four consecutive patients/158 lesions with suspected coronary artery disease underwent computed tomography (CT) and 40 MHz intravascular ultrasound imaging (iMap-IVUS) in cardiac catheterization. Cross-sectional CT slices were semiautomatically traced from base to apex of the heart. Using a 3D workstation, EATV was measured as the sum of fat areas (-190 to -30 Hounsfield units [HU])...
October 25, 2018: International Heart Journal
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