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https://www.readbyqxmd.com/read/28101398/wide-field-retinal-optical-coherence-tomography-with-wavefront-sensorless-adaptive-optics-for-enhanced-imaging-of-targeted-regions
#1
James Polans, Brenton Keller, Oscar M Carrasco-Zevallos, Francesco LaRocca, Elijah Cole, Heather E Whitson, Eleonora M Lad, Sina Farsiu, Joseph A Izatt
The peripheral retina of the human eye offers a unique opportunity for assessment and monitoring of ocular diseases. We have developed a novel wide-field (>70°) optical coherence tomography system (WF-OCT) equipped with wavefront sensorless adaptive optics (WSAO) for enhancing the visualization of smaller (<25°) targeted regions in the peripheral retina. We iterated the WSAO algorithm at the speed of individual OCT B-scans (~20 ms) by using raw spectral interferograms to calculate the optimization metric...
January 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28101172/adenosine-triphosphate-stress-99m-tc-methoxyisobutylisonitrile-gated-myocardial-perfusion-imaging-efficacy-in-diagnosing-stent-restenosis-following-coronary-stent-implantation
#2
Pengfei Zhang, Song Chen, Yang Li, Qiuhong Du, Lijuan Wang, Yingxian Sun, Yaming Li
Coronary stent restenosis rate following implantation is considerably high. The adenosine stress gated myocardial perfusion imaging (G-MPI) method has been widely used in the diagnosis, risk stratification and prognosis evaluation of coronary heart disease; however, the high cost of adenosine limits its clinical application. The aim of the present study was to investigate the efficacy of adenosine triphosphate (ATP) stress (99m)Tc-methoxyisobutylisonitrile ((99m)Tc-MIBI) G-MPI for diagnosis in-stent restenosis following coronary stent implantation...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28096838/a-rare-case-of-myocardial-bridge-involving-left-anterior-descending-obtuse-marginal-and-ramus-intermediate-coronary-arteries
#3
Tuncay Kiris, Diyar Koprulu, Muzaffer Elmali, Gonul Zeren, Guney Erdogan
Myocardial bridging, a congenital coronary anomaly, is a cluster of myocardial fibers crossing over the epicardial coronary arteries. It is most frequently seen in the left anterior descending artery (LAD), and rarely involves the circumflex (CX) and right coronary artery (RCA). We report a patient with an unusual coronary bridge crossing over the left anterior descending, obtuse marginal and ramus intermediate branches. The patient presented with exercise-induced angina pectoris that was relieved with medical therapy...
December 2016: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/28088002/radiochemical-studies-pre-clinical-investigation-and-preliminary-clinical-evaluation-of-170-tm-edtmp-prepared-using-in-house-freeze-dried-edtmp-kit
#4
Tapas Das, Ajit Shinto, Koramadai K Kamaleshwaran, Haladhar D Sarma, Sahiralam Khan Mohammed, Arpit Mitra, Sangita Lad, M G R Rajan, Sharmila Banerjee
The objective of the present work is to formulate (170)Tm-EDTMP using an in-house freeze-dried EDTMP kit and evaluate its potential as a bone pain palliation agent. Patient dose of (170)Tm-EDTMP was prepared with high radiochemical purity using the lyophilized kit at room temperature within 15min. Pre-clinical evaluation in normal Wistar rats revealed selective skeletal accumulation with extended retention. Preliminary clinical investigation in 8 patients with disseminated skeletal metastases exhibited selective uptake in the bone and retention therein for a long duration...
January 5, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28087071/development-of-delineation-for-the-left-anterior-descending-coronary-artery-region-in-left-breast-cancer-radiotherapy-an-optimized-organ-at-risk
#5
Jie Lee, Kai-Lung Hua, Shih-Ming Hsu, Jhen-Bin Lin, Chou-Hsien Lee, Kuo-Wei Lu, Kun-Yao Dai, Xu-Nian Huang, Jun-Zhao Huang, Meng-Hao Wu, Yu-Jen Chen
BACKGROUND AND PURPOSE: The left anterior descending coronary artery (LAD) and diagonal branches (DBs) are blurred on computed tomography (CT). We aimed to define the LAD region (LADR) with adequate inclusion of the LAD and DBs and contouring consistency. METHODS AND MATERIALS: The LADR was defined using coronary CT angiograms. The inclusion ratio was used to assess the LAD and DBs inclusion by the LADR. Four radiation oncologists delineated the LAD and LADR, using contrast-enhanced CT of 15 patients undergoing left breast radiotherapy...
January 10, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28079848/high-resolution-computed-tomography-to-differentiate-chronic-diffuse-infiltrative-lung-diseases-with-chronic-multifocal-consolidation-patterns-using-logical-analysis-of-data
#6
Constance De Margerie-Mellon, Geneviève Dion, Julien Darlay, Imene Ridene, Marianne Kambouchner, Nadia Brauner, Michel Brauner, Dominique Valeyre, Pierre-Yves Brillet
BACKGROUND: Chronic lung consolidation has a limited number of differential diagnoses requiring distinct managements. The aim of the study was to investigate how logical analysis of data (LAD) can support their diagnosis at HRCT (high-resolution computed tomography). METHODS: One hundred twenty-four patients were retrospectively included and classified into 8 diagnosis categories: sarcoidosis (n=35), connective tissue disease (n=21), adenocarcinoma (n=17), lymphoma (n=13), cryptogenic organizing pneumonia (n=11), drug-induced lung disease (n=9), chronic eosinophilic pneumonia (n =7) and miscellaneous (n=11)...
December 23, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/28073988/posteromedial-papillary-muscle-rupture-due-to-squeezing-of-the-left-anterior-descending-coronary-artery
#7
Kaoru Hattori, Kozo Fukui, Nobuaki Suzuki, Kazuo Ito
An unusual case of posteromedial papillary muscle (PPM) rupture due to isolated left anterior descending (LAD) artery ischaemia, associated with severe myocardial bridge contraction, is presented. The unusual blood supply to the PPM was associated with its apical origin and apex-forming LAD.
January 10, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28065691/difference-in-vascular-response-between-sirolimus-eluting-and-everolimus-eluting-stents-in-ostial-left-circumflex-artery-after-unprotected-left-main-as-observed-by-optical-coherence-tomography
#8
Yusuke Fujino, Guilherme F Attizzani, Satoko Tahara, Toru Naganuma, Kensuke Takagi, Hiroto Yabushita, Wei Wang, Kentaro Tanaka, Takahiro Matsumoto, Hiroyoshi Kawamoto, Yuya Yamada, Shinnosuke Amano, Yusuke Watanabe, Takayuki Warisawa, Tomohiko Sato, Satoru Mitomo, Naoyuki Kurita, Hisaaki Ishiguro, Koji Hozawa, Takahiro Tsukahara, Masahiro Motosuke, Hiram G Bezerra, Shotaro Nakamura, Sunao Nakamura
BACKGROUND: Kissing-balloon technique (KBT) is commonly performed during percutaneous coronary intervention of distal unprotected left main coronary artery (ULM) aiming at obtaining optimal opening of the side branch (left circumflex artery; LCX) ostium. Nonetheless, detailed evaluation of vascular response to stents in LCX ostium is lacking. We therefore evaluated the vascular response to different drug-eluting stents (DES) in ostial LCX after ULM by means of optical coherence tomography (OCT)...
December 23, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28060840/an-isochore-framework-underlies-chromatin-architecture
#9
Kamel Jabbari, Giorgio Bernardi
A recent investigation showed the existence of correlations between the architectural features of mammalian interphase chromosomes and the compositional properties of isochores. This result prompted us to compare maps of the Topologically Associating Domains (TADs) and of the Lamina Associated Domains (LADs) with the corresponding isochore maps of mouse and human chromosomes. This approach revealed that: 1) TADs and LADs correspond to isochores, i.e., isochores are the genomic units that underlie chromatin domains; 2) the conservation of TADs and LADs in mammalian genomes is explained by the evolutionary conservation of isochores; 3) chromatin domains corresponding to GC-poor isochores (e...
2017: PloS One
https://www.readbyqxmd.com/read/28056234/-effect-of-intracoronary-autologous-bone-marrow-mononuclear-cells-transplantation-on-arrhythmia-in-canines
#10
J Tang, G Y Sun, T Chen, Y D Wang, J Zhang, X Q Qi
Objective: To observe the survival and the differentiation of grafted bone marrow cells (BM-MNCs) in host myocardium. To observe whether BM-MNCs transplantation can potentially cause arrhythmia and whether the BM-MNCs transplantation can alter the spatial distribution of connexins, important mediator for arrhythmia genesis after myocardial infarction. Methods: Acute myocardial infarction (AMI) was induced by left anterior descending coronary artery (LAD) ligation in hybrid canine. BM-MNCs suspension was prepared by density centrifugation...
December 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28051022/risk-factors-of-contrast-induced-acute-kidney-injury-in-patients-undergoing-emergency-percutaneous-coronary-intervention
#11
Ying Yuan, Hong Qiu, Xiao-Ying Hu, Tong Luo, Xiao-Jin Gao, Xue-Yan Zhao, Jun Zhang, Yuan Wu, Hong-Bing Yan, Shu-Bin Qiao, Yue-Jin Yang, Run-Lin Gao
BACKGROUND: Previous studies of contrast-induced acute kidney injury (CI-AKI) were mostly based on selective percutaneous coronary intervention (PCI) cases, and risk factors of CI-AKI after emergency PCI are unclear. The aim of this study was to explore the risk factors of CI-AKI in a Chinese population undergoing emergency PCI. METHODS: A total of 1061 consecutive patients undergoing emergency PCI during January 2013 and June 2015 were enrolled and divided into CI-AKI and non-CI-AKI group...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28049601/validation-of-left-atrial-volume-estimation-by-left-atrial-diameter-from-the-parasternal-long-axis-view
#12
Grazia Canciello, Giovanni de Simone, Raffaele Izzo, Alessandra Giamundo, Filomena Pacelli, Costantino Mancusi, Maurizio Galderisi, Bruno Trimarco, Maria-Angela Losi
BACKGROUND: Measurement of left atrial (LA) volume (LAV) is recommended for quantification of LA size. Only LA anteroposterior diameter (LAd) is available in a number of large cohorts, trials, or registries. The aim of this study was to evaluate whether LAV may be reasonably estimated from LAd. METHODS: One hundred forty consecutive patients referred to our outpatient clinics were prospectively enrolled to measure LAd from the long-axis view on two-dimensional echocardiography...
December 31, 2016: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28048492/th-cd-206-07-determination-of-patient-specific-myocardial-mass-at-risk-using-computed-tomography-angiography
#13
L Hubbard, B Ziemer, S Malkasian, J Lipinski, B Sadeghi, H Javan, B Dertli, E Groves, S Molloi
PURPOSE: To evaluate the accuracy of a patient-specific coronary perfusion territory assignment algorithm that uses CT angiography (CTA) and a minimum-cost-path approach to assign coronary perfusion territories on a voxel-by-voxel basis for determination of myocardial mass at risk. METHODS: Intravenous (IV) contrast (370 mg/mL iodine, 25 mL, 7 mL/s) was injected centrally into five swine (35-45 kg) and CTA was performed using a 320-slice CT scanner at 100 kVp and 200 mA...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047196/th-ab-207a-11-anatomical-and-functional-assessment-of-coronary-artery-disease-using-low-dose-whole-organ-dynamic-computed-tomography
#14
L Hubbard, B Ziemer, J Lipinski, S Malkasian, B Sadeghi, H Javan, B Dertli, E M Groves, S Molloi
PURPOSE: To evaluate the accuracy of a low-dose, first-pass-analysis (FPA) dynamic computed tomography angiography and perfusion (CTAP) technique, for whole-organ anatomical and functional assessment of coronary artery disease (CAD). METHODS: An angioplasty balloon was advanced into the left anterior descending (LAD) coronary artery of five swine (35-45 kg) to induce several levels of stenosis at maximal hyperemia (intracoronary adenosine, 240 µg/min). Reference fluorescence microspheres and intravenous contrast (370 mg/mL iodine, 25 mL, 7 mL/s) were injected centrally and dynamic imaging was performed using a 320-slice CT scanner at 100 kVp and 200 mA...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046429/su-f-t-418-evaluation-of-organs-at-risk-oar-sparing-in-left-breast-irradiation-techniques
#15
A Saini, C Hwang, I Das
PURPOSE: To compare dose to organs at risk (OAR) for left sided breast radiation therapy with comparable planning target volume (PTV) coverage in three techniques; free breathing in supine position (FB), deep inspirational breath hold in supine (DIBH) and free breathing in prone position (PP). METHODS: Ten left sided breast cancer patients suitable for this study underwent a CT scan in three techniques e.g. supine, FB and DIBH and prone position (PP). One radiation oncologist contoured the PTV and OAR (cardiac components) based on RTOG guidelines...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042918/the-neurostimulation-appropriateness-consensus-committee-nacc-safety-guidelines-for-the-reduction-of-severe-neurological-injury
#16
Timothy R Deer, Tim J Lamer, Jason E Pope, Steven M Falowski, David A Provenzano, Konstantin Slavin, Stanley Golovac, Jeffrey Arle, Joshua M Rosenow, Kayode Williams, Porter McRoberts, Samer Narouze, Sam Eldabe, Shivanand P Lad, Jose A De Andrés, Eric Buchser, Philippe Rigoard, Robert M Levy, Brian Simpson, Nagy Mekhail
INTRODUCTION: Neurostimulation involves the implantation of devices to stimulate the brain, spinal cord, or peripheral or cranial nerves for the purpose of modulating the neural activity of the targeted structures to achieve specific therapeutic effects. Surgical placement of neurostimulation devices is associated with risks of neurologic injury, as well as possible sequelae from the local or systemic effects of the intervention. The goal of the Neurostimulation Appropriateness Consensus Committee (NACC) is to improve the safety of neurostimulation...
January 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28042909/the-neurostimulation-appropriateness-consensus-committee-nacc-recommendations-for-infection-prevention-and-management
#17
Timothy R Deer, David A Provenzano, Michael Hanes, Jason E Pope, Simon J Thomson, Marc A Russo, Tory McJunkin, Michael Saulino, Louis J Raso, Shivanand P Lad, Samer Narouze, Steven M Falowski, Robert M Levy, Ganesan Baranidharan, Stanley Golovac, Didier Demesmin, William O Witt, Brian Simpson, Elliot Krames, Nagy Mekhail
INTRODUCTION: The use of neurostimulation for pain has been an established therapy for many decades and is a major tool in the arsenal to treat neuropathic pain syndromes. Level I evidence has recently been presented to substantiate the therapy, but this is balanced against the risk of complications of an interventional technique. METHODS: The Neurostimulation Appropriateness Consensus Committee (NACC) of the International Neuromodulation Society convened an international panel of well published and diverse physicians to examine the best practices for infection mitigation and management in patients undergoing neurostimulation...
January 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28042905/the-neurostimulation-appropriateness-consensus-committee-nacc-recommendations-on-bleeding-and-coagulation-management-in-neurostimulation-devices
#18
Timothy R Deer, Samer Narouze, David A Provenzano, Jason E Pope, Steven M Falowski, Marc A Russo, Honorio Benzon, Konstantin Slavin, Julie G Pilitsis, Kenneth Alo, Jonathan D Carlson, Porter McRoberts, Shivanand P Lad, Jeffrey Arle, Robert M Levy, Brian Simpson, Nagy Mekhail
INTRODUCTION: The Neurostimulation Appropriateness Consensus Committee (NACC) was formed by the International Neuromodulation Society (INS) in 2012 to evaluate the evidence to reduce the risk of complications and improve the efficacy of neurostimulation. The first series of papers, published in 2014, focused on the general principles of appropriate practice in the surgical implantation of neurostimulation devices. The NACC was reconvened in 2014 to address specific patient care issues, including bleeding and coagulation...
January 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28040272/myocardial-strain-may-be-useful-in-differentiating-takotsubo-cardiomyopathy-from-left-anterior-descending-coronary-artery-ischemia
#19
LiYing Cai, Karima Addetia, Diego Medvedofsky, Kirk T Spencer
BACKGROUND: Stress-induced cardiomyopathy (SCM) is characterized by transient apical wall motion abnormalities of the left ventricle (LV) in the absence of obstructive coronary artery disease. Although the echocardiographic findings of SCM mimic those of left anterior descending coronary artery ischemia or infarction (LAD), the regional LV wall motion pattern and degree of RV involvement may differ. METHODS: We sought to systematically assess regional LV and RV function with myocardial strain imaging to assess if ventricular involvement may differ between SCM and LAD...
December 21, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28039203/ischemic-preconditioning-in-pigs-a-causal-role-for-signal-transducer-and-activator-of-transcription-3
#20
Sabine Gent, Andreas Skyschally, Petra Kleinbongard, Gerd Heusch
Ischemic preconditioning (IPC), i.e. brief episodes of non-lethal myocardial ischemia/reperfusion (IR) prior to sustained ischemia with subsequent reperfusion, reduces infarct size in all tested species so far, including humans. In rodents, the cardioprotective signal transduction causally involves an activation of AKT, ERK1/2 and STAT3. However, there are apparent species differences in the signal transduction between rodents and larger mammals such as pigs, where data on IPC's signal transduction are inconsistent for AKT and ERK1/2...
December 30, 2016: American Journal of Physiology. Heart and Circulatory Physiology
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