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Tumor of sacrum

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https://www.readbyqxmd.com/read/29299501/giant-cell-tumor-of-the-sacrum-series-of-19-patients-and-review-of-the-literature
#1
Khodamorad Jamshidi, Abolfazl Bagherifard, Alireza Mirzaei, Mehrdad Bahrabadi
There are still some debates regarding the best treatment of Giant Cell Tumor (GCT) of the sacrum. Since GCT of this location is rare, therapeutic strategies are mainly based on the treatment of GCT in other anatomic locations. The objective of this study was to evaluate the oncologic and clinical results of surgical management of sacral GCT with and without local adjuvant therapy. Medical records of 19 patients diagnosed with GCT of the sacrum, were retrospectively reviewed. Sixteen patients were treated by intralesional curettage and three patients with marginal resection...
November 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29296040/evaluation-and-performance-of-arccheck-and-film-using-gamma-criteria-in-pre-treatment-quality-assurance-of-stereotactic-ablative-radiotherapy
#2
Prabhakar Ramachandran, Abdulrahman Tajaldeen, David Taylor, Derrick Wanigaratne, Karl Roozen, Moshi Geso
Aim: The aim of this study is to assess the use of ArcCHECK (AC) as an alternative method to replace film dosimetry for pre-treatment quality assurance (QA) of three-dimensional conformal radiation therapy, intensity-modulated radiation therapy (IMRT), and volumetric-modulated arc therapy (VMAT) stereotactic ablative radiotherapy (SABR) treatment plans. Materials and Methods: Twenty-five patients with a varied diagnosis of lung, spine, sacrum, sternum, ribs, scapula, and femur undergoing SABR were selected for this study...
October 2017: Journal of Medical Physics
https://www.readbyqxmd.com/read/29250326/palliative-treatment-efficacy-of-glucose-inhibition-combined-with-chemotherapy-for-non-small-cell-lung-cancer-with-widespread-bone-and-brain-metastases-a-case-report
#3
Yongping Liu, Yaping Zhang, Xibao Mao, Qiufeng Qi, Ming Zhu, Changsong Zhang, Xuefeng Pan, Yang Ling
Otto Warburg observed in 1924 that cancer cells were dependent exclusively on glycolysis for the production of energy even in the presence of oxygen (the 'Warburg effect'). Consequently, cancer cells require ~19 times more glucose uptake to obtain equivalent amounts of energy as normal cells. The Warburg effect is the scientific basis for positron emission tomography (PET), which has markedly improved cancer detection. During chemotherapy, cancer cells may upregulate their expression of multi-drug resistance proteins and ultimately cause treatment failure...
December 2017: Biomedical Reports
https://www.readbyqxmd.com/read/29236139/-notochordal-tumors-benign-notochordal-tumors-and-chordomas
#4
REVIEW
T F E Barth, A von Witzleben, P Möller, S Scheil-Bertram
Benign notochordal tumors (BNCT) and chordomas are primary bone tumors of the spine with a predominant localization in the sacrum and clival region followed by the vertebral bodies. Besides the most common variant (NOS [not otherwise specified] with hepatoid or renal carcinoma cell-like differentiation) chordomas with chondroid, and polymorphic to anaplastic morphology are described. An unfavorable variant are pediatric chordomas with a loss of INI-1. BNCT and chordomas are characterized by the following immunohistological profile: vimentin+, cytokeratin+/-, epithelial membrane antigen (EMA)+/-, S100 protein+/-, brachyury+...
December 13, 2017: Der Pathologe
https://www.readbyqxmd.com/read/29181683/analysis-of-the-infiltrative-features-of-chordoma-the-relationship-between-micro-skip-metastasis-and-postoperative-outcomes
#5
Toru Akiyama, Koichi Ogura, Tabu Gokita, Satoshi Tsukushi, Shintaro Iwata, Tomoki Nakamura, Akihiko Matsumine, Tsukasa Yonemoto, Yoshihiro Nishida, Kazuo Saita, Akira Kawai, Seiichi Matsumoto, Takehiko Yamaguchi
BACKGROUND: Chordomas are very rare primary malignant bone tumors that arise commonly from the sacrum (50-60%) and clivus (25-35%). Chordomas have a high rate of recurrence. The authors confirmed a unique histologic infiltration pattern of chordomas that resembles a skip-metastatic lesion in normal tissue around tumor, which they named "micro-skip metastasis." This study aimed to examine the correlations between the clinicopathologic features of chordomas, including micro-skip metastasis, and the clinical outcomes, including overall survival, local recurrence-free survival, and distant metastasis-free survival...
November 27, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29170836/phase-contrast-cerebrospinal-fluid-flow-magnetic-resonance-imaging-in-qualitative-evaluation-of-patency-of-csf-flow-pathways-prior-to-infusion-of-chemotherapeutic-and-other-agents-into-the-fourth-ventricle
#6
Rajan P Patel, Clark W Sitton, Leena M Ketonen, Ping Hou, Jason M Johnson, Seferino Romo, Stephen Fletcher, Manish N Shah, Marcia Kerr, Wafik Zaky, Michael E Rytting, Soumen Khatua, David I Sandberg
PURPOSE: Nuclear medicine studies have previously been utilized to assess for blockage of cerebrospinal fluid (CSF) flow prior to intraventricular chemotherapy infusions. To assess CSF flow without nuclear medicine studies, we obtained cine phase-contrast MRI sequences that assess CSF flow from the fourth ventricle down to the sacrum. METHODS: In three clinical trials, 18 patients with recurrent malignant posterior fossa tumors underwent implantation of a ventricular access device (VAD) into the fourth ventricle, either with or without simultaneous tumor resection...
November 23, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29114282/multicompartmental-primary-spinal-extramedullary-tumors-value-of-an-interdisciplinary-approach
#7
Guruprasad Bettaswamy, Paurush Ambesh, Raj Kumar, Rabi Narayan Sahu, Kuntal Kanti Das, Awadhesh Kumar Jaiswal, Arun Kumar Srivastava, Sanjay Behari
Background: Primary extramedullary tumors involving multiple compartments around the spine are a technically demanding group of tumors whose extent traverses beyond the normal confines of those anatomical regions which fall in the common domain of neurosurgeons. In the following series, we present 12 patients who were diagnosed with primary spinal extramedullary tumors with multicompartmental extension, and whose surgical management was facilitated by a combined multidisciplinary approach involving surgeons of other superspecialties...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29076324/innovation-in-the-planning-of-v-y-rotation-advancement-flaps-a-template-for-flap-design
#8
Utku C Dölen, Uğur Koçer
Local flaps exhibit excellent color matching that no other type of flap can compete with. Moreover, surgery using a local flap is easier and faster than surgery using a distant or free flap. However, local flaps can be much more difficult to design. We designed 2 templates to plan a V-Y rotation advancement flap. The template for a unilateral V-Y rotation advancement flap was used on the face (n=5), anterior tibia (n=1), posterior axilla (n=1), ischium (n=1), and trochanter (n=2). The template for a bilateral flap was used on the sacrum (n=8), arm (n=1), and anterior tibia (n=1)...
October 27, 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/29054328/ependymomas-arising-outside-of-the-central-nervous-system-a-case-series-and-literature-review
#9
Shlomit Yust Katz, David Cachia, Carlos Kamiya Matsuok, Adriana Olar, Brett Theeler, Marta Penas Prado, Mark R Gilbert, Terri Armstrong
BACKGROUND: Extracranial and extraspinal ependymomas are extremely rare tumors mostly published in the literature as case reports. METHODS: MD Anderson Cancer Center institutional database was screened for patients with extra CNS ependymomas over a 25 year period. RESULTS: Eight patients with extra CNS ependymoma were identified. Five cases originated in the sacrum or subcutaneous sacral area, and the other 3 cases originating in the breast, lung and adnexa of the uterus...
October 17, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29044582/provider-views-on-the-management-of-ewing-sarcoma-of-the-spine-and-pelvis
#10
Chong Zhu, Kristofor A Olson, Michael Roth, David S Geller, Richard G Gorlick, Jonathan Gill, Nadia N Laack, R L Randall
BACKGROUND: Curative therapy for ES requires both chemotherapy and local control of primary tumor. There is no universally accepted standard approach to local control modalities. This survey was conducted to determine practice patterns and factors influencing the choice to offer various local control modalities to patients with ES of the spine and pelvis. METHODS: The survey consisted of four scenarios involving a 15-year-old girl who presented with Ewing sarcoma of thoracic vertebra, sacrum, iliac wing, and acetabulum with or without neurologic compromise...
October 16, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29017308/ganglioneuroma-of-the-sacrum
#11
Donguk Lee, Woo Jin Choe, So Dug Lim
Presacral ganglioneuromas are extremely rare benign tumors and fewer than 20 cases have been reported in the literature. Ganglioneuromas are difficult to be differentiated preoperatively from tumors such as schwannomas, meningiomas, and neurofibromas with imaging modalities. The retroperitoneal approach for resection of presacral ganglioneuroma was performed for gross total resection of the tumor. Recurrence and malignant transformation of these tumors is rare. Adjuvant chemotherapy or radiation therapy is not indicated because of their benign nature...
September 2017: Korean Journal of Spine
https://www.readbyqxmd.com/read/28951177/5-aminolevulinic-acid-based-photodynamic-therapy-of-chordoma-in-vitro-experiments-on-a-human-tumor-cell-line
#12
Jan F Cornelius, Lennert Eismann, Lara Ebbert, Brigitte Senger, Athanasios K Petridis, Marcel Alexander Kamp, Rüdiger V Sorg, Hans Jakob Steiger
BACKGROUND: Chordomas are very rare tumors of the skull base and the sacrum. They show infiltrating and destructive growth and are known to be chemo- and radio-resistant. After surgical resection, the recurrence rate is high and overall survival limited. As current adjuvant treatments are ineffective, new treatment concepts are urgently needed. 5-aminolevulinic acid-based photodynamic therapy (5-ALA based PDT) showed promising results for malignant gliomas. However, it is unknown so far, whether chordomas accumulate protoporphyrin IX (PPIX) after application of 5-ALA and whether they are sensitive to subsequent 5-ALA based PDT...
September 22, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28948491/acetabular-reconstruction-with-femoral-head-autograft-after-intraarticular-resection-of-periacetabular-tumors-is-durable-at-short-term-followup
#13
Xiaodong Tang, Wei Guo, Rongli Yang, Taiqiang Yan, Shun Tang, Dasen Li
BACKGROUND: Pelvic reconstruction after periacetabular tumor resection is technically difficult and characterized by a high complication rate. Although endoprosthetic replacement can result in immediate postoperative functional recovery, biologic reconstructions with autograft may provide an enhanced prognosis in patients with long-term survival; however, little has been published regarding this approach. We therefore wished to evaluate whether whole-bulk femoral head autograft that is not contaminated by tumor can be used to reconstruct segmental bone defects after intraarticular resection of periacetabular tumors...
December 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28943899/surgical-management-of-pelvic-ewing-s-sarcoma-in-children-and-adolescents
#14
Hongbin Fan, Zheng Guo, Jun Fu, Xiangdong Li, Jing Li, Zhen Wang
The present study describes a novel surgical strategy used to treat immature pelvic Ewing's sarcoma (ES), one made possible owing to the intrinsic structure of the skeletally immature pelvis. A total of 12 children and adolescents with open triradiate cartilage received limb-salvage surgeries following a diagnosis of pelvic ES. In total, 3 patients with iliac lesions (2 lesions with extension into the sacrum) received surgical tumor excisions and allograft reconstructions. Another 8 patients with periacetabular lesions received trans-acetabular osteotomies and allograft reconstructions...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28934935/treatment-and-outcomes-of-tumor-induced-osteomalacia-associated-with-phosphaturic-mesenchymal-tumors-retrospective-review-of-12-patients
#15
Qing-Yao Zuo, Hong Wang, Wei Li, Xiao-Hui Niu, Yan-Hong Huang, Jia Chen, Yu-Hua You, Bao-Yue Liu, Ai-Min Cui, Wei Deng
BACKGROUND: Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by severe hypophosphatemia and osteomalacia. Nonspecific symptoms make the diagnosis elusive. In addition, locating the responsible tumor(s) is challenging. The aim of this study was to investigate the clinical management and outcomes of TIO. METHODS: The clinical features, diagnostic procedures, treatment, and outcomes of 12 patients were reviewed retrospectively. RESULTS: The cohort comprised six men and six women (mean age 45...
September 21, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28905737/giant-cell-tumor-of-bone-revisited
#16
Andreas F Mavrogenis, Vasileios G Igoumenou, Panayiotis D Megaloikonomos, Georgios N Panagopoulos, Panayiotis J Papagelopoulos, Panayotis N Soucacos
Giant cell tumor (GCT) of bone is a locally aggressive benign neoplasm that is associated with a large biological spectrum ranging from latent benign to highly recurrent and occasionally metastatic malignant bone tumor. It accounts for 4-10% of all bone tumors and typically affects the meta-epiphyseal region of long bones of young adults. The most common site involved is the distal femur, followed by the distal radius, sacrum, and proximal humerus. Clinical symptoms are nonspecific and may include local pain, swelling, and limited range of motion of the adjacent joint...
2017: SICOT-J
https://www.readbyqxmd.com/read/28890010/lumbosacral-subdural-hematoma-following-glioblastoma-multiforme-resection-possible-radiographic-evidence-for-the-downward-migration-of-intracranial-blood
#17
Gabriella M Paisan, Thomas J Buell, Daniel Raper, Ashok Asthagiri
Spinal subdural hematomas (SSDHs) are rare and usually associated with bleeding diatheses, trauma, iatrogenic injury, spinal vascular malformations, or intraspinal tumors. We report a case of a 75-year-old male who developed a symptomatic lumbosacral SSDH after undergoing resection of a right temporal glioblastoma multiforme. The patient subsequently recovered and was discharged home. Over the next two weeks he developed progressively worsening symptoms of lower back pain, lower extremity weakness, and urinary retention...
September 7, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28826304/moderate-dose-escalation-with-volumetric-modulated-arc-therapy-improves-outcome-in-rectal-cancer
#18
Cedric Stuyck, Marilyn Wegge, Philippe Bulens, Ines Joye, Karin Haustermans
BACKGROUND: Locally advanced rectal cancer is frequently treated with a long course of preoperative chemoradiotherapy. We investigated the effect of moderate dose escalation with volumetric modulated arc therapy (VMAT) up to 50 Gy in 25 fractions compared to 3D conformal radiotherapy (3D-CRT) to 45 Gy in 25 fractions in rectal cancer patients. Dose-volume parameters, acute toxicity, and complete response rates were compared. MATERIAL AND METHODS: For both groups, 65 patients were selected from our database through availability...
November 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28781793/activation-of-the-arachidonic-acid-metabolic-pathway-and-induction-of-sleep-disturbance-by-sacral-osteoblastoma-a-case-report
#19
Mitsunori Ozaki, Kazuya Nishioka, Akihiko Kimura, Toshikazu Kondo, Naoyuki Nakao
Osteoblastomas are benign bone tumors that produce prostaglandin and promote inflammation. The aim of the present study was to describe the clinical and radiological characteristics of a pediatric osteoblastoma case over an 8-month postoperative follow-up. The case involved an 11-year-old female patient with normal somatic development, presenting with a chief complaint of sleep disturbance. The patient had no spontaneous pain or other readily evident possible causes. Magnetic resonance imaging (MRI) revealed a neoplastic lesion in the sacrum, with peritumoral edema...
August 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28748455/resection-of-rectal-cancer-resembling-submucosal-tumor-that-was-preoperatively-diagnosed-with-endoscopic-ultrasound-guided-biopsy
#20
Akimitsu Tanio, Hiroaki Saito, Keigo Ashida, Shouichi Urushibara, Manabu Yamamoto, Naruo Tokuyasu, Teruhisa Sakamoto, Soichiro Honjo, Yoshihiko Maeta, Yoshiyuki Fujiwara
BACKGROUND: Colorectal cancer (CRC) resembling submucosal tumor (SMT; CRC/SMT) is very rare. Because its biopsy is challenging, accurate preoperative diagnosis is also very rare. CASE PRESENTATION: A 55-year-old woman with a high serum carcinoembryonic antigen level underwent a computed tomography colonoscopy, which showed extrinsic rectum compression. A coronal magnetic resonance image showed a 4-cm low-intensity tumor between her rectum and sacrum. Endoscopic ultrasound (EUS) showed a 30-mm low-echoic lesion originating from the rectum...
December 2017: Surgical Case Reports
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