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https://www.readbyqxmd.com/read/27857879/stat3-inhibition-as-a-therapeutic-strategy-for-chordoma
#1
Anthony C Wang, John H Owen, Waleed M Abuzeid, Shawn L Hervey-Jumper, Xiaobing He, Mikel Gurrea, Meijuan Lin, David B Altshuler, Richard F Keep, Mark E Prince, Thomas E Carey, Xing Fan, Erin L McKean, Stephen E Sullivan
Objective Signal transducer and activator of transcription (STAT) proteins regulate key cellular fate decisions including proliferation and apoptosis. STAT3 overexpression induces tumor growth in multiple neoplasms. STAT3 is constitutively activated in chordoma, a tumor with a high recurrence rate despite maximal surgical and radiation treatment. We hypothesized that a novel small molecule inhibitor of STAT3 (FLLL32) would induce significant cytotoxicity in sacral and clival chordoma cells. Methods Sacral (UCh1) and clival (UM-CHOR-1) chordoma cell lines were grown in culture (the latter derived from primary tumor explants)...
December 2016: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/27857455/imaging-in-spinal-posterior-epidural-space-lesions-a-pictorial-essay
#2
Foram B Gala, Yashant Aswani
Spinal epidural space is a real anatomic space located outside the dura mater and within the spinal canal extending from foramen magnum to sacrum. Important contents of this space are epidural fat, spinal nerves, epidural veins and arteries. Due to close proximity of posterior epidural space to spinal cord and spinal nerves, the lesions present with symptoms of radiculopathy and/or myelopathy. In this pictorial essay, detailed anatomy of the posterior epidural space, pathologies affecting it along with imaging pearls to accurately diagnose them are discussed...
July 2016: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/27853665/systematic-review-and-meta-analysis-of-en-bloc-vertebrectomy-compared-with-intralesional-resection-for-giant-cell-tumors-of-the-mobile-spine
#3
REVIEW
Panya Luksanapruksa, Jacob M Buchowski, Weerasak Singhatanadgige, David B Bumpass
Study Design Systematic review and meta-analysis. Objective To compare the recurrence and perioperative complication rate of en bloc vertebrectomy (EV) and intralesional resection (IR) in the giant cell tumor of the mobile spine (SGCT). Methods We systematically searched publications in the PubMed and Embase databases for reports of SGCTs, excluding the sacrum. Two reviewers independently assessed all publications. A meta-analysis was performed using local recurrence and postoperative complications as the primary outcomes of interest...
December 2016: Global Spine Journal
https://www.readbyqxmd.com/read/27832810/eccrine-porocarcinoma-of-the-vulva-a-case-report-and-review-of-the-literature
#4
Ayako Fujimine-Sato, Masafumi Toyoshima, Shogo Shigeta, Asami Toki, Takashi Kuno, Izumi Sato, Mika Watanabe, Hitoshi Niikura, Nobuo Yaegashi
BACKGROUND: Malignant tumors arising from the vulva account for only 0.6 % of all cancers in female patients. The predominant histologic type, representing about 90 % of these malignancies, is squamous cell carcinoma. Eccrine porocarcinoma is a rare malignant tumor arising from sweat glands. The incidence of eccrine porocarcinoma is estimated at 0.005-0.01 % of all cutaneous tumors. To the best of our knowledge, only seven previous cases of vulvar eccrine porocarcinoma have been reported in the English-language literature...
November 10, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27819871/atypical-notochordal-cell-tumors-a-series-of-notochordal-derived-tumors-that-defy-current-classification-schemes
#5
Jodi M Carter, Doris E Wenger, Peter S Rose, Carrie Y Inwards
By the current WHO classification, benign notochordal cell tumor (BNCT) and chordoma comprise the entire spectrum of notochordal-derived tumors. They have defined radiologic and histologic criteria, and differ considerably in management and clinical outcome. Chordomas are malignant tumors; they show progressive, destructive growth and have the capacity for metastasis. In contrast, BNCT are benign and show limited intraosseous growth. Patients with BNCT can be managed with serial imaging or conservative excision, whereas patients with spinal/sacral chordomas typically undergo radical en bloc resection often with adjuvant therapy and significant morbidity...
November 4, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27785074/locally-advanced-rectal-cancer-management-challenges
#6
REVIEW
R F Kokelaar, M D Evans, M Davies, D A Harris, J Beynon
Between 5% and 10% of patients with rectal cancer present with locally advanced rectal cancer (LARC), and 10% of rectal cancers recur after surgery, of which half are limited to locoregional disease only (locally recurrent rectal cancer). Exenterative surgery offers the best long-term outcomes for patients with LARC and locally recurrent rectal cancer so long as a complete (R0) resection is achieved. Accurate preoperative multimodal staging is crucial in assessing the potential operability of advanced rectal tumors, and resectability may be enhanced with neoadjuvant therapies...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27753782/management-of-locally-recurrent-chordoma-of-the-mobile-spine-and-sacrum-a-systematic-review
#7
Tamir Ailon, Radmehr Torabi, Charles G Fisher, Laurence D Rhines, Michelle J Clarke, Chetan Bettegowda, Stefano Boriani, Yoshiya J Yamada, Norio Kawahara, Peter P Varga, John H Shin, Arjun Saghal, Ziya L Gokaslan
STUDY DESIGN: Systematic review. OBJECTIVE: To determine evidence-based guidelines for the management of locally recurrent spinal chordoma. SUMMARY OF BACKGROUND DATA: Chordoma of the spine is a low-grade malignant tumor with a strong propensity for local recurrence. Salvage therapy is challenging due to its relentless nature and refractoriness to adjuvant therapies. There are currently no guidelines regarding the best management of recurrent chordoma...
October 15, 2016: Spine
https://www.readbyqxmd.com/read/27722984/clinicopathological-features-of-a-series-of-27-cases-of-post-denosumab-treated-giant-cell-tumors-of-bones-a-single-institutional-experience-at-a-tertiary-cancer-referral-centre-india
#8
Bharat Rekhi, Vivek Verma, Ashish Gulia, Nirmala A Jambhekar, Subhash Desai, Shashikant L Juvekar, Jyoti Bajpai, Ajay Puri
Giant cell tumor of bone (GCTB) is mostly a benign tumor, but associated with recurrences and metastasis. Lately, denosumab is being utilized in the treatment of certain GCTBs. Twenty-seven tumors, analyzed in the present study, occurred in 16 males and 11 females (M: F = 1.45:1), in the age-range of 16 to 47 years (mean = 29.5, median = 29). Most tumors were identified in the tibia(6) and femur(6), followed by the humerus(3), radius(3), pelvis(3), fibula(3), sacrum(1), metacarpal(1) and metatarsal(1) bones...
October 8, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27695210/gluteal-teratoma-a-rare-site-of-extragonadal-teratoma
#9
Hemonta Kr Dutta, Pronami Borah, Mauchumi Baruah
Extragonadal teratomas are rarely encountered in infants and children. These tumors are reported in retroperitoneum, floor of the mouth, mediastinum, craniofacial region or even in the solid organs of the body. Most of the gluteal teratomas reported in the literature are in fact, lateralized sacrococcygeal teratomas. We are reporting a case of unilateral big gluteal teratoma in a 6-year-old girl. The tumor did not have any connection with the sacrum or coccyx and was successfully removed. Histology showed well-differentiated bowel as well as fetiform structures...
October 2016: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/27689246/hemisacrectomy-with-preservation-of-the-contralateral-sacral-nerve-roots-and-sacroiliac-joint-for-pelvic-neurofibrosarcoma-in-a-7-year-old-child-case-report-with-2-year-follow-up
#10
Ali H Palejwala, Jared S Fridley, Krystal Garcia, Sanjeev A Vasudevan, David Khechoyan, Surya Rednam, Chester J Koh, Andrew Jea
Neurofibrosarcoma is rare in the pediatric age group. A malignant tumor of the sacrum presents significant challenges, especially if the goals are to resect with wide and clean surgical margins and to achieve acceptable functional outcomes. The authors report a case of this rare tumor affecting the sacrum and sacral nerve roots of a 7-year-old girl and review the role of total hemisacrectomy sparing the contralateral sacral nerve roots and lumbopelvic reconstruction in the treatment of this disease. This patient is, to the best of the authors' knowledge, the youngest to be treated in this manner...
September 30, 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27601840/epithelioid-osteoblastoma-of-maxilla-a-rare-and-aggressive-variant-of-a-benign-neoplasm-at-an-uncommon-site
#11
Vandana Rana, Vivek Saxena, Kavita Sahai, Giriraj Singh
Osteoblastoma (OB) is an uncommon benign bone-forming tumor accounting for <1% of all bone neoplasms. Unlike conventional OB, its small subset variant "Epithelioid osteoblastoma (EO)" is characterized by its propensity for local invasion and recurrent behavior. This rare variant of an uncommon tumor when occurs in an atypical site can lead to diagnostic problems more so due to ambiguous clinico-radiologic presentation. This was what faced in the present case of 18-year-old female with a swelling in upper jaw...
May 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/27553491/predicting-clinical-outcomes-in-chordoma-patients-receiving-immunotherapy-a-comparison-between-volumetric-segmentation-and-recist
#12
Kathleen E Fenerty, Les R Folio, Nicholas J Patronas, Jennifer L Marté, James L Gulley, Christopher R Heery
BACKGROUND: The Response Evaluation Criteria in Solid Tumors (RECIST) are the current standard for evaluating disease progression or therapy response in patients with solid tumors. RECIST 1.1 calls for axial, longest-diameter (or perpendicular short axis of lymph nodes) measurements of a maximum of five tumors, which limits clinicians' ability to adequately measure disease burden, especially in patients with irregularly shaped tumors. This is especially problematic in chordoma, a disease for which RECIST does not always adequately capture disease burden because chordoma tumors are typically irregularly shaped and slow-growing...
August 23, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27509195/safety-and-local-control-of-radiation-therapy-for-chordoma-of-the-spine-and-sacrum-a-systematic-review
#13
Brenton Pennicooke, Ilya Laufer, Arjun Sahgal, Peter P Varga, Ziya L Gokaslan, Mark H Bilsky, Yoshiya J Yamada
STUDY DESIGN: Systematic literature review. OBJECTIVE: To assess the toxicity, common radiation doses, and local control (LC) rates of radiation therapy for chordoma of the spine and sacrum and identify the difference in LC and toxicity between adjuvant, salvage, and primary therapy using radiation. SUMMARY OF BACKGROUND DATA: Chordoma of the spine is typically a low-grade malignant tumor thought to be relatively radioresistant with a high rate of local recurrence and the potential for metastases...
October 15, 2016: Spine
https://www.readbyqxmd.com/read/27411285/-advance-in-surgical-treatment-of-primary-sacrum-tumor
#14
REVIEW
Leyuan Zang, Tongwei Chu
OBJECTIVE: To summarize the research progress of surgical treatment for primary sacrum tumor. METHODS: The domestic and foreign related literature about surgical treatment of primary sacrum tumor, and many aspects of its surgical procedures, intraoperative hemostasis, pelvic reconstruction, protection of sacral nerve, complications, and prognosis was summarized and analyzed. RESULTS: The operation is the major therapy for primary sacrum tumor...
April 2016: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/27398253/bi-lobed-perirectal-epidermoid-cyst-an-unusual-cause-of-hematochezia-in-a-middle-aged-woman
#15
A O Atolagbe, O Ogunleye, C T Apakama
Perirectal epidermoid cysts are congenital cysts originating from the ectodermal germ cell layer of the hind gut. Their presenting symptoms are most often nonspecific and distinguishing them from other presacral developmental cysts often present a diagnostic and therapeutic dilemma. We present a 58-year-old woman who presented with chronic dyschezia and hematochezia of a few days duration and no prior colonoscopies. Initial blood work and tumor markers were unremarkable. Pelvic magnetic resonance imaging (MRI) showed a 7...
May 2016: Annals of Medical and Health Sciences Research
https://www.readbyqxmd.com/read/27388197/intraosseous-hibernoma-in-the-sacrum-of-an-adult
#16
Lorraine Westacott, Angus Collins, Ian Dickenson
Hibernoma is an uncommon lipomatous tumor composed of brown adipose cells that until recently has only ever been described in soft tissue locations. This report describes the histological features of a discrete lesion in the sacrum of an 84-year-old lady. Biopsy of this lesion demonstrated that it consisted predominantly of multivacuolated lipocytes with a morphological and immunohistochemical profile consistent with brown fat cells. The lesion was diagnosed as an intraosseous hibernoma. This is the 16th report in the English literature of a hibernoma occurring outside of a soft tissue location...
July 7, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27384723/malignant-pelvic-tumors-involving-the-sacrum-surgical-approaches-and-procedures-based-on-a-new-classification
#17
Yi-Dan Zhang, Wei Guo, Rong-Li Yang, Xiao-Dong Tang, Tai-Qiang Yan, Tao Ji
OBJECTIVE: To introduce a new classification of Enneking type IV pelvic tumors involving the sacrum and a corresponding system of standardized surgical approaches and procedures for resection of such tumors, and to investigate the feasibility and therapeutic effect of the new system. METHODS: Data on 59 patients treated between February 2003 and February 2013 by standardized surgical approaches and procedures were retrospectively reviewed. The study subjects comprised 28 male and 31 female patients with a mean age at diagnosis of 36 years (range, 2-72 years)...
May 2016: Orthopaedic Surgery
https://www.readbyqxmd.com/read/27330631/clear-cell-chondrosarcoma-of-the-humerus
#18
Saeed Elojeimy, William A Ahrens, Brian Howard, Joshua C Patt, Taylor Stone, Jeffrey S Kneisl, Puneet Bhargava
Clear-cell chondrosarcoma is a rare, low-grade variant of chondrosarcoma characterized by slow growth, low metastatic potential, and a predilection for local recurrence long after treatment. We report an unusually aggressive case of clear-cell chondrosarcoma of the humerus with early metastasis to multiple bony sites including femur, thoracic and lumbar spine, sacrum, and iliac bone. Our purpose is to alert physicians to the sarcoma's potential for aggressive behavior, necessitating closer and more frequent followups for early detection and treatment of tumor recurrence and metastasis...
2013: Radiology case reports
https://www.readbyqxmd.com/read/27299100/inferior-vena-caval-tumor-thrombus-in-giant-cell-tumor-of-sacrum-an-unusual-complication-treated-with-multimodality-management
#19
Ashish Gulia, Ajay Puri, Suman Byregowda, Bharat Rekhi, Siddhartha Laskar, Nitin Shetty
INTRODUCTION: Giant cell tumor is the most common benign lesion encountered. It accounts for 5 % of all skeletal tumors. It mainly affects the epiphysis of long bones and rarely axial bones. In axial bones, sacrum is the most common site to be affected. CASE REPORT: A 23 year old female with giant cell tumor of sacrum was treated initially with conservative treatment (serial angioembolisation and bisphosphonates). Later intralesional curettage was done as the patient started developing bladder and bowel disturbances after two sessions of angioembolisation...
October 2015: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/27274412/chondromyxoid-fibroma-of-the-sacrum-a-case-report-and-literature-review
#20
Tanya Minasian, Chad Claus, Omid R Hariri, Zhe Piao, Syed A Quadri, Robert Yuhan, Darren Leong, Vartan Tashjian
BACKGROUND: Chondromyxoid fibroma (CMF) is an extremely rare, benign cartilaginous tumor that makes up <0.5% of all bone tumors, typically presenting in the second or third decade of life. CMF of the sacrum is exceedingly rare, with only seven documented cases reported in the neurosurgical literature. CASE DESCRIPTION: We report a case of a 35-year-old female with a 3 month history of lower back pain after sustaining a fall on her sacrum/coccyx presenting with a progressive complaint of localized lower back pain, occasional urinary retention without incontinence, gluteal hypesthesia, and pressure below the gluteal crease...
2016: Surgical Neurology International
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