Rik Ossenkoppele, Brendan I Cohn-Sheehy, Renaud La Joie, Jacob W Vogel, Christiane Möller, Manja Lehmann, Bart N M van Berckel, William W Seeley, Yolande A Pijnenburg, Maria L Gorno-Tempini, Joel H Kramer, Frederik Barkhof, Howard J Rosen, Wiesje M van der Flier, William J Jagust, Bruce L Miller, Philip Scheltens, Gil D Rabinovici
Alzheimer's disease (AD) can present with distinct clinical variants. Identifying the earliest neurodegenerative changes associated with each variant has implications for early diagnosis, and for understanding the mechanisms that underlie regional vulnerability and disease progression in AD. We performed voxel-based morphometry to detect atrophy patterns in early clinical stages of four AD phenotypes: Posterior cortical atrophy (PCA, "visual variant," n=93), logopenic variant primary progressive aphasia (lvPPA, "language variant," n=74), and memory-predominant AD categorized as early age-of-onset (EOAD, <65 years, n=114) and late age-of-onset (LOAD, >65 years, n=114)...
November 2015: Human Brain Mapping