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PCa advanced to late-stage

Avishek Kumar Singh, Sheetalnath Babasaheb Rooge, Aditi Varshney, Madavan Vasudevan, Ankit Bhardwaj, Senthil Kumar Venugopal, Nirupama Trehanpati, Manoj Kumar, Robert Geffers, Vijay Kumar, Shiv Kumar Sarin
Hepatitis B virus (HBV) can manipulate the microRNA (miRNA) regulatory networks in infected cells to create a permissive environment for viral replication, cellular injury, disease onset, and its progression. The aim of the present study was to understand the miRNA networks and their target genes in the liver of hepatitis B patients involved in HBV replication, liver injury, and liver fibrosis. We investigated differentially expressed miRNAs by microarray in liver biopsy samples from different stages of HBV infection and liver disease (immune-tolerant [n = 8], acute viral hepatitis [n = 8], no fibrosis [n = 16], early [F1+F2, n = 19] or late [F3+F4, n = 14] fibrosis, and healthy controls [n = 7])...
May 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Ying Peng, Austin R Prater, Susan L Deutscher
There is a crucial need to identify new biomarkers associated with aggressive prostate cancer (PCa) including those associated with cancer stem cells (CSCs). CD44v6, generated by alternative splicing of CD44, has been proposed as a CSC biomarker due to its correlation with aggressive PCa disease. We hypothesized that phage display selected peptides that target CD44v6 may serve as theranostic agents for aggressive PCa. Here, a 15 amino acid peptide ("PFT") was identified by affinity selection against a peptide derived from the v6 region of CD44v6...
October 17, 2017: Oncotarget
Cedric D'Hue, Michael Moore, Don-John Summerlin, Alan Jarmusch, Clint Alfaro, Avinash Mantravadi, Arnaud Bewley, D Gregory Farwell, R Graham Cooks
RATIONALE: Desorption electrospray ionization mass spectrometry (DESI-MS) has demonstrated utility in differentiating tumor from adjacent normal tissue in both urologic and neurosurgical specimens. We sought to evaluate if this technique had similar accuracy in differentiating oral tongue squamous cell carcinoma (SCC) from adjacent normal epithelium due to current issues with late diagnosis of SCC in advanced stages. METHODS: Fresh frozen samples of SCC and adjacent normal tissue were obtained by surgical resection...
January 30, 2018: Rapid Communications in Mass Spectrometry: RCM
Eric Tran, Matthew Paquette, Justin Jay, Jeremy Hamm, Mitchell Liu, Graeme Duncan, Tom Pickles, Scott Tyldesley
PURPOSE: To determine whether the survival benefit associated with prolonged androgen deprivation therapy (ADT) and radiotherapy (EBRT) varies with baseline estimates of overall survival in cT3-4 prostate cancer patients (PCa). METHODS AND MATERIALS: In 1997, the BC Cancer Agency adopted as standard a policy of prolonged ADT (>18months) with EBRT for locally advanced PCa. Two cohorts of cT3-T4 PCa treated with EBRT were selected: 1993-1995 (early: N=725) and 1999-2001 (late: N=584)...
August 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Eleanor Fitall, Dayo Jagun, Kristi Mitchell, Peter St John Francis, Hong Tang, Kyung Min Song
273 Background: Prostate cancer (PCa) is the leading cancer for men in the United States (US) and identified by the Centers for Medicare & Medicaid Services (CMS) as one of the top 20 high-impact Medicare conditions experienced by beneficiaries. Thus, there is increasing focus by stakeholders to measure and achieve high-value, quality care in PCa. However, quality measurement is particularly difficult in oncology. Our aim was to assess the current landscape of PCa quality measures (QMs) in the US. METHODS: Published literature and online resources from the past 5 years were reviewed to identify PCa QMs and general oncology QMs relevant to PCa...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Rik Ossenkoppele, Brendan I Cohn-Sheehy, Renaud La Joie, Jacob W Vogel, Christiane Möller, Manja Lehmann, Bart N M van Berckel, William W Seeley, Yolande A Pijnenburg, Maria L Gorno-Tempini, Joel H Kramer, Frederik Barkhof, Howard J Rosen, Wiesje M van der Flier, William J Jagust, Bruce L Miller, Philip Scheltens, Gil D Rabinovici
Alzheimer's disease (AD) can present with distinct clinical variants. Identifying the earliest neurodegenerative changes associated with each variant has implications for early diagnosis, and for understanding the mechanisms that underlie regional vulnerability and disease progression in AD. We performed voxel-based morphometry to detect atrophy patterns in early clinical stages of four AD phenotypes: Posterior cortical atrophy (PCA, "visual variant," n=93), logopenic variant primary progressive aphasia (lvPPA, "language variant," n=74), and memory-predominant AD categorized as early age-of-onset (EOAD, <65 years, n=114) and late age-of-onset (LOAD, >65 years, n=114)...
November 2015: Human Brain Mapping
Chang Xu, Fang-Fang Han, Xian-Tao Zeng, Tong-Zu Liu, Shen Li, Zheng-Yan Gao
BACKGROUND: Since the late 1960s, the average global supply of fat has increased by 20 g per capita per day. While fat intake has been considered a potential risk factor for prostate cancer (Pca), the hypothesis from previous epidemiologic studies remained equivocal. MATERIALS AND METHODS: Relevant cohort studies were identified through a literature search in PubMed, ScienceDirect and Wiley Online Library up to March 1, 2015. A systematic review and dose-response meta-analysis were used to assess the relationship between fat intake and the risk for Pca...
2015: PloS One
Shalini Moningi, Avani S Dholakia, Siva P Raman, Amanda Blackford, John L Cameron, Dung T Le, Ana M C De Jesus-Acosta, Amy Hacker-Prietz, Lauren M Rosati, Ryan K Assadi, Shirl Dipasquale, Timothy M Pawlik, Lei Zheng, Matthew J Weiss, Daniel A Laheru, Christopher L Wolfgang, Joseph M Herman
BACKGROUND: Stereotactic body radiation therapy (SBRT) is a promising option for patients with pancreatic cancer (PCA); however, limited data support its efficacy. This study reviews our institutional experience of SBRT in the treatment of locally advanced (LAPC) and borderline resectable (BRPC) PCA. METHODS: Charts of all PCA patients receiving SBRT at our institution from 2010 to 2014 were reviewed. Most patients received pre-SBRT chemotherapy. Primary endpoints included overall survival (OS) and local progression-free survival (LPFS)...
July 2015: Annals of Surgical Oncology
Bridget F Koontz, Alberto Bossi, Cesare Cozzarini, Thomas Wiegel, Anthony D'Amico
CONTEXT: Technological advances in radiation therapy delivery have permitted the use of high-dose-per-fraction radiation therapy (RT) for early-stage prostate cancer (PCa). Level 1 evidence supporting the safety and efficacy of hypofractionated RT is evolving as this modality becomes more widely utilized and refined. OBJECTIVE: To perform a systematic review of the current evidence on the safety and efficacy of hypofractionated RT for early-stage PCa and to provide in-context recommendations for current application of this technology...
October 2015: European Urology
Z Bannur, L K Teh, T Hennesy, W R W Rosli, N Mohamad, A Nasir, R Ankathil, Z A Zakaria, A Baba, M Z Salleh
BACKGROUND: Acute lymphoblastic leukaemia (ALL) has posed challenges to the clinician due to variable patients' responses and late diagnosis. With the advance in metabolomics, early detection and personalised treatment are possible. METHODS: Metabolomic profile of 21 ALL patients treated with 6-mercaptopurine and 10 healthy volunteers were analysed using liquid chromatography/mass spectrometry quadrupole-time of flight (LC/MS Q-TOF). Principal components analysis (PCA), recursive analysis, clustering and pathway analysis were performed using MassHunter Qualitative and Mass Profiler Professional (MPP) software...
April 2014: Clinical Biochemistry
Johanna E Torfadottir, Unnur A Valdimarsdottir, Lorelei Mucci, Meir Stampfer, Julie L Kasperzyk, Katja Fall, Laufey Tryggvadottir, Thor Aspelund, Orn Olafsson, Tamara B Harris, Eirikur Jonsson, Hrafn Tulinius, Hans-Olov Adami, Vilmundur Gudnason, Laufey Steingrimsdottir
OBJECTIVE: To determine whether consumption of whole-grain rye bread, oatmeal, and whole-wheat bread, during different periods of life, is associated with risk of prostate cancer (PCa). METHODS: From 2002 to 2006, 2,268 men, aged 67-96 years, reported their dietary habits in the AGES-Reykjavik cohort study. Dietary habits were assessed for early life, midlife, and current life using a validated food frequency questionnaire. Through linkage to cancer and mortality registers, we retrieved information on PCa diagnosis and mortality through 2009...
June 2012: Cancer Causes & Control: CCC
C Weber
The diagnostics and treatment of prostate cancer (PCa) are currently encumbered with several problems: Only a small proportion of men attend medical check-ups. The PSA count, although invaluable in the early detection of PCa, is not being paid for by health insurance schemes, because its indiscriminate use would result in overdiagnosis of PCa which, in turn would burden patients with avoidable morbidity and the mutually supportive community with unnecessary costs. Accordingly, some clinically insignificant tumors are being detected and treated although treatment appears unnecessary...
November 2011: Der Radiologe
Erica M Carlisle, Valeriy Poroyko, Michael S Caplan, John A Alverdy, Donald Liu
INTRODUCTION: Necrotizing enterocolitis (NEC) affects 5-10% of infants born weighing less than 1500 g. Most models of NEC recapitulate late-stage disease with gut necrosis and elevated inflammatory mediators. Evaluation of NEC at earlier, less lethal stages of disease will allow investigation of initial disease triggers and may advance our understanding of temporal relationships between factors implicated in NEC pathogenesis. In this manuscript, we describe our investigation of early NEC and test the hypothesis that bacteria and inflammatory mediators differ between animals with early NEC and disease free animals...
March 22, 2011: PloS One
S Leo, C Accettura, V Lorusso
BACKGROUND: Castration-resistant prostate cancer (CRPC) refers to patients who no longer respond to surgical or medical castration. Standard treatment options are limited. OBJECTIVE: To review the concepts and rationale behind targeted agents currently in late-stage clinical testing for patients with CRPC. METHODS: Novel targeted therapies in clinical trials were identified from registries. The Medline database was searched for all relevant reports published from 1996 to October 2009...
2011: Chemotherapy
Jonathan A Hensel, Diptiman Chanda, Sanjay Kumar, Anandi Sawant, William E Grizzle, Gene P Siegal, Selvarangan Ponnazhagan
BACKGROUND: The antimicrobial peptide, leucine-leucine-37 (LL-37), stimulates proliferation, angiogenesis, and cellular migration, inhibits apoptosis and is associated with inflammation. Since these functional processes are often exaggerated in cancer, the aim of the present study was to investigate the expression and role of LL-37 in prostate cancer (PCa) and establish its value as a therapeutic target. METHODS: We evaluated the expression of LL-37 and the murine orthologue, cathelicidin-related antimicrobial peptide (CRAMP) in human and murine prostate tumors, respectively...
May 2011: Prostate
Lina Matera
Tumor antigens (TA) are promising candidates for targeted treatment of prostate cancer (PCa). Critical issues in the preparation of dendritic cell (DC)-based TA vaccines are the DC maturation state and the appropriateness of the TA. Prostate-specific antigen (PSA) and prostate acide pshosphatase (PAP) presented by DC have produced encouraging results and PAP-loaded DCs are at late-stage development for PCa patients. TAs indispensable for tumor survival and propagation are now emerging as first choice TAs for future vaccines...
April 2010: Cancer Treatment Reviews
Kim N Chi, Anders Bjartell, David Dearnaley, Fred Saad, Fritz H Schröder, Cora Sternberg, Bertrand Tombal, Tapio Visakorpi
CONTEXT: Castration-resistant prostate cancer (CRPC) refers to patients who no longer respond to surgical or medical castration. Standard treatment options are limited. OBJECTIVE: To review the concepts and rationale behind targeted agents currently in late-stage clinical testing for patients with CRPC. EVIDENCE ACQUISITION: Novel targeted therapies in clinical trials were identified from registries. The MEDLINE database was searched for all relevant reports published from 1996 to October 2009...
October 2009: European Urology
Alyse M DeHaan, Natalie M Wolters, Evan T Keller, Kathleen M Woods Ignatoski
BACKGROUND: Bone metastasis occurs frequently in advanced prostate cancer (PCa) patients; however, it is not known why this happens. The epidermal growth factor receptor (EGFR) ligand EGF is available to early stage PCa; whereas, TGF-alpha is available when PCa metastasizes. Since the microenvironment of metastases has been shown to play a role in the survival of the tumor, we examined whether the ligands had effects on cell survival and proliferation in early and late PCa. METHODS: We used LNCaP cells as a model of early stage, non-metastatic PCa and the isogenic C4-2B cells as a model of late stage, metastatic PCa...
April 1, 2009: Prostate
Jun Lu, Zhao-yang Chen, Wei Wang, Yuan-feng Zhang, Xiao-fu Qiu, Li-chao Zhang, Wei-lie Hu, Wen-feng Xu, Zhang-qun Ye
OBJECTIVE: To evaluate the clinical effect of transrectal high-intensity focused ultrasound (HIFU) in the treatment of prostate cancer (PCa). METHODS: A total of 57 PCa patients, 27 localized and 30 advanced, underwent transrectal HIFU with the Sonab- late 500, the localized group treated by transrectal HIFU only, while the advanced group by transrectal HIFU combined with androgen ablation. RESULTS: For the HIFU treatment, the mean operating time, hospital stay and follow-up were 111 mm (ranging from 86 to 153 mm), 3...
November 2007: Zhonghua Nan Ke Xue, National Journal of Andrology
S Mugikura, S Takahashi, S Higano, R Shirane, N Kurihara, S Furuta, M Ezura, A Takahashi
BACKGROUND AND PURPOSE: In childhood-onset moyamoya disease, the angiographic disease process of stenoocclusive lesions is progressive, and cerebral infarctions often develop as a result of ischemia. Our purpose was to determine how the severity of stenoocclusive lesions in the anterior and posterior circulations affects the distribution of cerebral infarction in patients with childhood-onset moyamoya disease. METHODS: In 69 patients with childhood-onset moyamoya disease, angiograms were reviewed for stenoocclusive lesions, and CT scans, MR images, or both were reviewed for the sites and extent of cerebral infarction...
February 1999: AJNR. American Journal of Neuroradiology
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