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https://www.readbyqxmd.com/read/21839228/impact-of-recurrent-glomerulonephritis-on-renal-graft-survival
#1
K Toledo, M J Pérez-Sáez, M D Navarro, R Ortega, M D Redondo, M L Agüera, A Rodríguez-Benot, P Aljama
BACKGROUND: Glomerular disease causes graft loss in the intermediate and long term, especially recurrent primary renal disease, negatively impacting graft survival. Thus, it must be considered a differential diagnosis in the evaluation of chronic graft dysfunction. METHODS: The objectives of our study were to compare the impacts of primary glomerular disease on graft survival and association with interstitial fibrosis/tubular atrophy (IFTA) or transplant glomerulopathy...
July 2011: Transplantation Proceedings
https://www.readbyqxmd.com/read/20386928/characterisation-of-renal-immune-cell-infiltrates-in-children-with-nephrotic-syndrome
#2
Kerstin Benz, Maike Büttner, Katalin Dittrich, Valentina Campean, Jörg Dötsch, Kerstin Amann
There is increasing evidence that not only T cells but also B cells may play an important role in the pathogenesis of idiopathic nephrotic syndrome (NS). We have evaluated the infiltrating immune cells found in renal biopsies from 38 children with NS using immunohistochemistry techniques involving antibodies against T cells (CD3, CD4, CD8, FoxP3), B cells (CD20), macrophages (CD68) and follicular dendritic cells (CD21). Kidney biopsies with thin basement membrane disease were used as controls. We found higher numbers of interstitial CD3-positive T cells and macrophages in patients with focal segmental glomerulosclerosis (FSGS) than in those with minimal change glomerulopathy (MCGN) and in the controls, and significantly lower FoxP3-positive cells in patients with FSGS, MCGN and steroid-dependent NS than in the controls...
July 2010: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/19182757/proliferative-glomerulonephritis-with-acute-renal-failure-a-rare-manifestation-in-seronegative-rheumatoid-arthritis
#3
P K Dutta, I H Khan
A 55 years old lady with advanced rheumatoid arthritis (RA) presented with severe acute renal failure with significant proteinuria preceded by fever for 14 days. She had no history of taking drugs usually responsible for glomerulonephritis, neither had she any clinico-biochemical evidence of peri-infectious glomerulonephritis. Acute interstitial nephritis (AIN) was excluded by absence of eosinophilia and eosinophils in urine. Renal biopsy reveled absence of amyloidosis and showed Focal segmental proliferative glomerulonephritis (FSGN)...
January 2009: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/17936231/hepatitis-c-and-kidney-disease
#4
P Coccoli, P Esposito, B Cianciaruso, A Pota, B Visciano, R Annecchini, G Parrilli
Hepatitis C virus (HCV) infection is often associated with kidney diseases such as membranoproliferative glomerulonephritis (MPGN), with and without cryoglobulinemia, membranous glomerulonephritis (MGN) or glomerulosclerosis (FSGN). The aim of our study was to determine the frequency of HCV with or without hypertransaminasemia in patients with chronic nephropathy in the predialytic phase. We tested 340 subjects with chronic renal insufficiency (CRI) from our hospital's nephrology outpatient clinic for anti-HCV antibodies...
September 2007: Digestive and Liver Disease
https://www.readbyqxmd.com/read/17255215/expression-of-nestin-in-the-podocytes-of-normal-and-diseased-human-kidneys
#5
Wei Su, Jing Chen, Haichun Yang, Li You, Lan Xu, Xiang Wang, Ruixi Li, Lu Gao, Yong Gu, Shanyan Lin, Hong Xu, Matthew D Breyer, Chuan-Ming Hao
The complex cyto-architecture of the podocyte is critical for glomerular permselectivity. The present study characterizes the expression of nestin, an intermediate filament protein, in human kidneys. In normal kidneys, nestin was detected at the periphery of glomerular capillary loops. Colabeling showed nestin was expressed in WT1-positive cells. Within the podocyte, nestin immunoreactivity was present in the cell body and primary process. This was supported by immunoelectron microscopy. Nestin also colocalized with vimentin in the periphery of capillary loops but not in the mesangium...
May 2007: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/17097332/linking-floral-symmetry-genes-to-breeding-system-evolution
#6
Susan Kalisz, Richard H Ree, Risa D Sargent
Understanding the genetic basis of ecologically important traits is a major focus of evolutionary research. Recent advances in molecular genetic techniques should significantly increase our understanding of how regulatory genes function. By contrast, our understanding of the broader macro-evolutionary implications of developmental gene function lags behind. Here we review published data on the floral symmetry gene network (FSGN), and conduct phylogenetic analyses that provide evidence of a link between floral symmetry and breeding systems in angiosperms via dichogamy...
December 2006: Trends in Plant Science
https://www.readbyqxmd.com/read/16400231/recurrent-glomerulonephritis-in-living-kidney-transplantation
#7
G Spasovski, N Ivanovski, J Masin-Spasovska, S Dzikova, L Grcevska, G Petrusevska, Lj Lekovski, Z Popov, M Polenaković
Glomerulonephritis (GN) is one of the most frequent causes of end-stage renal disease. Recurrent GN can occur very early after transplantation in up to 20% of renal-allograft recipients and should be considered with late graft dysfunction in 2-5%. Importantly, diagnosis of a clinically silent recurrence of the disease will pass undetected unless transplant centers have a policy of protocol biopsies. In addition, the classification of the type of recurrent GN should be done with data on electron microscopy and immunofluorescence, in order to promote prompt treatment and a strategy for long-term graft survival...
December 2005: Prilozi
https://www.readbyqxmd.com/read/14974372/-serum-concentration-and-urinary-excretion-of-soluble-receptors-for-tumor-necrosis-factor-in-patients-with-primary-glomerulonephritis
#8
Feliks Kacprzyk
In sera and urine of healthy and diseased patients two soluble types of TNF receptors--p55--sTNF RI and p75--sTNF RII have been detected. They can protect cells against excessive cytotoxic activity of TNF-alpha in vitro and in vivo. The aim of the study was to investigate the prognostic significance and role of sTNF R in various types of glomerular diseases. We studied 49 patients with primary glomerular diseases (5 minimal change--MC; 4 focal glomerulosclerosis--FSGN; 4 membranous nephropathy--MN; 12 mesangial proliferative GN--MSPGN; 18 IgA nephropathy--IgAN; and 6 membranoproliferative GN--MPGN) and 10 healthy persons...
October 2003: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/12107901/-primary-glomerulopathies-incidence-dynamics-and-clinical-manifestations-of-morphological-variants
#9
B R Dzhanaliev, V A Varshavskiĭ, A A Laurinavichus
4400 biopsies studied in the pathology department of I.M. Sechenov Moscow Medical Academy in 1970-1999 were analysed. Primary glomerulopathy (PGP) was found in 62.4% of nephrobiopsies. PGP was represented by mesangioproliferative glomerulonephritis (MPGN, 48.9%), mesangiocapillary glomerulonephritis (MCGN, 18.4%), membranous nephropathy (MN, 13.4%), focal segmentary glomerulosclerosis/hyalinosis (FSGH, 7.8%), minimal changes (MC, 5.6%). Mainly of nephrotic origin were MC, MN, FSGH. The hematuric form was primarily represented by MPGN...
March 2002: Arkhiv Patologii
https://www.readbyqxmd.com/read/11769443/treatment-of-children-in-the-u-s-with-end-stage-renal-disease-esrd
#10
J E Lewy
USA 10,434 children with End State Renal Disease or chronic renal insufficiency have been followed by NAPRTCS. 5958 renal transplants have been performed. Haemoidalysis preceeded Tx in 28%, PD in 47% and 24% were preemptive transplants. The most common diagnoses were obstructive uropathy, renal dysplasia, FSGN, reflux nephropathy and CGN. 20.4 were < 5 and 24.9% < 12 years or age a transplant. 57.7% had living related donors. The most common therapy is with prednisone, cyclosporine and mycophenalate mofetile...
2001: Medicinski Arhiv
https://www.readbyqxmd.com/read/11588659/-effect-of-cyclosporin-a-on-renal-function-in-patients-with-glomerulonephritis
#11
P Heering, A Schneider, B Grabensee, J Plum
BACKGROUND AND OBJECTIVE: Cyclosporin A ( CsA) plays a confounding part in the treatment of nephrotic syndrome. Renal hemodynamics and glomerular permselectivity were investigated in patients with glomerulonephritis to analyse the antiproteinuric action of CsA and to differentiate between nephrotoxic and immunosuppressive effects. METHODS: We studied 19 patients with nephrotic syndrome after 6 months of treatment with CsA (membranous glomerulonephritis-MGN, n = 10; focal segmental sclerosing glomerulonephritis - FSGN, n = 5; minimal changes glomerulonephritis - MCGN, n = 4)...
October 5, 2001: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/10844803/chronic-inflammatory-demyelinating-polyradiculoneuropathy-and-severe-peripheral-oedema-a-renal-explanation
#12
R D Henderson, H G Healy, P A McCombe, C M Lander
Inflammatory demyelinating neuropathies have been associated with membranous and focal sclerosing glomerulonephritis. Here we describe a 58 year old man with a clinical history, physical examination and laboratory investigations consistent with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), who also had severe lower limb and sacral oedema resistant to medical therapy. Mild proteinuria was present and a renal biopsy showed features consistent with focal sclerosing glomerulonephritis (FSGN)...
March 2000: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/10202612/hla-identical-sibling-renal-transplantation-a-21-yr-single-center-experience
#13
COMPARATIVE STUDY
A M de Mattos, W M Bennett, J M Barry, D J Norman
Human lymphocyte antigen (HLA)-identical sibling organs offer the best long-term outcomes for recipients of a renal transplant apart from an identical twin. Unlike cadaveric transplants, however, factors that affect long-term survival of these immunologically privileged grafts are not well described. We reviewed 108 HLA-identical transplants performed at our institution between January 1977 and February 1993. Variables chosen for graft survival analysis were: gender, age and ABO blood type of donors and recipients, panel reactivity antibodies (PRA), blood transfusions prior to transplant, pregnancies, and the underlying renal disease...
April 1999: Clinical Transplantation
https://www.readbyqxmd.com/read/8771242/long-term-cyclosporin-a-treatment-in-adults-with-refractory-nephrotic-syndrome
#14
K el-Reshaid, E Amer, J P Madda, M Kapoor
Patients with refractory nephrotic syndrome (NS) are at risk of infections, thrombosis, renal failure, or inherent side effects of immunosuppressive therapy. In the present study we investigated the efficacy of cyclosporin A (Cy A) in treatment of adult patients with steroid-refractory NS. Fifteen patients were included, 13 of whom were steroid resistant. Initial renal histology showed minimal-change glomerulonephritis (MCGN) in 3 patients, focal segmental glomerulonephritis (FSGN) in 6 patients, and membranous glomerulonephritis (MGN) in 6 patients...
November 1995: Renal Failure
https://www.readbyqxmd.com/read/8658613/recurrent-and-de-novo-glomerulonephritis-postrenal-transplantation
#15
R D Guttmann
Important conceptual advances in recent years have been made in the area of posttransplant GN mainly in the de novo form rather than in recurrent posttransplant glomerulonephritis. Important patient subgroups have been identified for whom a significant risk exists. In particular, those carriers of hepatitis C virus may develop immune-complex renal disease leading to both MGN and MPGN. A de novo form of FSGN may occur in very long-term renal allograft patients. A case cited of an identical twin donor and her recipient developing glomerulosclerosis more than 10 years posttransplant represents an instance where the provocative hyperfiltration hypothesis was not relevant...
June 1996: Transplantation Proceedings
https://www.readbyqxmd.com/read/8091126/lymphocyte-transformation-test-in-adult-patients-with-minimal-change-nephrotic-syndrome
#16
Y H al-Azzawi, N G al-Tawil, I A al-Shamaa
The lymphocyte transformation test was used to evaluate the cellular immune response in 31 adult patients with MCNS in comparison with 30 normal control and 49 patient (CRF, FSGN, MGN) control groups. The results showed that the stimulation indices of the lymphocytes in MCNS group were significantly lower than those of the normal control and patient control groups with the exception of CRF group. In cross studies, lymphocytes obtained from normal individuals were incubated in homologous serum obtained from MCNS patients in relapse, and lymphocytes from MCNS patients in relapse were incubated in normal homologous AB serum...
September 1994: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/3279574/immunopathologic-features-of-de-novo-membranous-nephropathy-in-renal-allografts
#17
H J Ward, M A Koyle
De novo membranous nephropathy (MN) is now one of the most common forms of posttransplant glomerular disease, second only to allograft glomerulopathy. We investigated several immunopathologic and physicochemical properties of the immune complex (IC) or IC components displayed in the sera of patients with de novo MN. The parameters studied included detection of small (9S) preformed IC by monoclonal rheumatoid factor, determination of IC isoelectric point by chromatofocusing, detection of cationic IgG spectrotypes (pI 8...
March 1988: Transplantation
https://www.readbyqxmd.com/read/2302866/dense-intramembranous-deposit-disease-a-clinical-comparison-of-histological-subtypes
#18
COMPARATIVE STUDY
C E Kashtan, B Burke, G Burch, S Gustav Fisker, Y Kim
The accumulation of osmiophilic dense deposits in glomerular mesangial and basement membranes (dense intramembranous deposit disease, or DIDD) is associated with variable histologic alterations of the kidneys. We compared clinical features and long-term renal outcome in 21 patients representing two histologic subtypes of DIDD, namely membranoproliferative glomerulonephritis (MPGN) and focal segmental glomerulonephritis (FSGN). We found that MPGN-type DIDD in 12 patients was associated with nephrotic syndrome in 12, persistent hypocomplementemia in 10 and progression to chronic renal insufficiency in 8...
January 1990: Clinical Nephrology
https://www.readbyqxmd.com/read/2253248/focal-sclerosing-glomerulonephritis-in-a-child-with-laurence-moon-biedl-syndrome
#19
A J Barakat, P Arianas, A D Glick, M G Butler
We report a 6-year-old white male with Laurence-Moon-Biedl syndrome and focal sclerosing glomerulonephritis (FSGN). To our knowledge, FSGN has not been reported previously in patients with this syndrome. We wish to alert the clinician to the wide variety of renal abnormalities that can be seen in patients with this rare, autosomal recessive disorder.
1990: Child Nephrology and Urology
https://www.readbyqxmd.com/read/779494/immunopathology-of-the-end-stage-kidney-immunoglobulin-and-complement-component-deposition-in-nonimmune-disease
#20
COMPARATIVE STUDY
J Velosa, K Miller, A F Michael
Seventy nephrectomy specimens from patients with end-stage renal disease, four renal biopsies from patients with focal sclerosing glomerulonephropathy (FSGN) and normal renal function, and 17 control biopsies from normal renal allograft donors (Group I) were studied by immunofluorescence with respect to deposition of immunoglobulins and classic and alternative complement (C) pathway components. The end-stage kidneys were divided into three groups according to etiology: 16 patients with immune-mediated glomerulonephritis (Group II), 22 patients with congenital and/or familial renal disease (Group III), and 32 patients with systemic or primary renal disease in which an immune-mediated injury could not be established (Group IV)...
July 1976: American Journal of Pathology
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