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Sacrum, tumor

Kensaku Abe, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Hiroyuki Inatani, Yu Aoki, Takashi Higuchi, Yuta Taniguchi, Hirotaka Yonezawa, Yoshihiro Araki, Hiroyuki Tsuchiya
BACKGROUND: Difficult resection of tumors from regions with complex local anatomy, such as the pelvis and sacrum, is likely to result in inadequate surgical margins (intralesional or marginal); this is because three-dimensional osteotomy is difficult particularly around the acetabulum. Additionally, removal of the joint makes reconstruction very difficult; thus, retention of good function also becomes difficult. In musculoskeletal oncology, computer navigation systems are still not widely used to prevent tumor-positive margins...
October 24, 2018: BMC Cancer
S El Aoud, H Tounsi, B Ben Ammou, E Chelbi, I Chaabène, I Ben Ahmed, R Amri, W Garbouj, K Bouzaidi
Secondary hypertension is relatively rare. Its etiologies are essentially renal or endocrine. The adrenocortical carcinoma, a rare malignant tumor, is one of the most exceptional causes of hypertension. We report the case of a young woman presenting with hypertension and ascites of great abundance. She had hypokalemia, hepatic cytolysis and cholestasis. Thoracic, abdominal and pelvic CT scans showed adrenal mass, liver and lung nodules, osteolytic lesions of the sacrum. The biopsy of liver nodules confirmed the diagnosis of a metastatic malignant adrenocortical carcinoma...
October 2, 2018: Annales de Cardiologie et D'angéiologie
Muhammad Naeem, Horacio Maluf, Jonathan C Baker, Jack W Jennings
Neoplasms of the sacrum are rare. Given the non-specific imaging findings in sacral lesions, the imaging-based differential diagnosis is always difficult. This case is about an adult with primary sacral neuroblastoma and we have discussed imaging and histopathological findings of this rare tumor.
September 30, 2018: Skeletal Radiology
Kazuhiro Kitajima, Shingo Yamamoto, Norihiko Kamikonya, Yukako Nakanishi, Yusuke Yamada, Takahiko Hashimoto, Toru Suzuki, Shuken Go, Akihiro Kanematsu, Michio Nojima, Koichiro Yamakado
We report here about a 59-year-old man with bone metastatic castration-resistant prostate cancer and biochemical progression, who underwent radium-223 (Ra-223) therapy, following previous treatment failure. Treatment response of osseous metastases was assessed with three 11 C-choline positron emission tomography/computed tomography (PET/CT) scans at baseline, after three cycles for early monitoring, as well as after six cycles of radium-223 therapy. Pretreatment 11 C-choline PET/CT showed multiple areas of increased focal activity in multiple cervical, thoracic, and lumbar vertebrae as well as in both ribs, right ileum, and left ischium...
July 9, 2018: Curēus
Fabrice Bing, Jonathan Vappou, Michel de Mathelin, Afshin Gangi
PURPOSE: To retrospectively evaluate the suitability of MRgHIFU for osteoid osteomas (OOs) and bone metastases in patients who underwent minimally-invasive percutaneous thermal ablation. MATERIALS AND METHODS: One hundred and sixty-seven lesions (115 metastases and 52 OOs) treated percutaneously between October 2014 and June 2017 were retrospectively analyzed. Tumors were located in the spine or sacrum (54), pelvis (43), limbs (50), ribs (17) and sternum (3). Tumor volume, matrix, anatomical environment and need for protection of surrounding structures or consolidation were assessed...
September 13, 2018: International Journal of Hyperthermia
Qi Lai, Qiang Wang, Hucheng Liu, Dejian Chen, Zongmiao Wan, Xiaolong Yu, Runsheng Guo, Xuqiang Liu, Min Dai, Bin Zhang
BACKGROUND: An osteoblastoma is a rare benign bone tumor characterized by formation of osteoid tissue and primitive bone and occurs more often in men than in women. They are often secondary to an osteoid osteoma and can be located at any site on the skeleton. Lesions generally involve the posterior elements of the spine, such as the pedicle and the lamina. CASE PRESENTATION: This study reports the case of a 25-year-old female who suffered from an osteoblastoma of the right sacrum with repeated swelling and pain in the right lumbosacral region for approximately 6 months...
September 7, 2018: Der Orthopäde
Shuzhong Liu, Xi Zhou, An Song, William A Li, Radhika Rastogi, Yipeng Wang, Yong Liu
RATIONALE: Malignant pheochromocytoma in the spine is a rare disease without standard curative managements so far. The objective of this article is to report a very rare case of malignant pheochromocytoma with sacrum metastases causing severe lumbosacral pain, which was presented with acute radiculopathy and treated with three operations combined with cement augmentation and stabilization. The management of these unique cases has yet to be well-documented. PATIENT CONCERNS: A 58-year-old man presented with lumbosacral pain, radiating pain and numbness of the right extremity...
August 2018: Medicine (Baltimore)
Bo Li, Jialin Li, Wujun Miao, Yuechao Zhao, Jian Jiao, Zhipeng Wu, Xinghai Yang, Haifeng Wei, Jianru Xiao
BACKGROUND: Schwannoma comprises approximately 25% of all spinal tumors, but there is little information published in the literature regarding this subject. Our aim in this study was to discuss diagnostic and prognostic factors for spinal schwannoma. METHODS: A retrospective study was performed to analyze the clinical and immunohistochemical data of patients with spinal schwannoma surgically treated in our center between 2005 and 2013. RESULTS: A total of 524 patients with spinal schwannoma were included in the study...
August 27, 2018: World Neurosurgery
Ning Zhou, Reinhold Schäfer, Tao Li, Meiyu Fang, Luying Liu
BACKGROUND: High-grade spindle cell sarcomas are a subtype of rare, undifferentiated pleomorphic sarcomas (UPSs) for which diagnosis is difficult and no specific treatment strategies have been established. The limited published data on UPSs suggest an aggressive clinical course, high rates of local recurrence and distant metastasis, and poor prognosis. CASE PRESENTATION: Here we present the unusual case of a 45-year-old male patient with a lumbosacral UPS extending into the sacrum...
August 22, 2018: BMC Cancer
Ali S Ahmed, Mark C Flemmer
Chordomas are a rare type of bone tumor that arises from the embryological remnant of the notochord. They originate at any point along the axial spine with the sacrum and the skull based region being the most commonly affected sites. Chordomas are slowly growing, indolent tumors, presenting insidiously, but also carry a high recurrence rate with a tendency to invade contiguous structure making their treatment challenging. The current standard of care for localized chordoma is aggressive cytoreductive surgery followed by high dose adjuvant radiotherapy...
August 2018: Oxford Medical Case Reports
Sarah Razaq, Falak Nigar, Sakinnah Hussain Naqvi
We report the case of a young 25-year male, a known case of end-stage renal disease (ESRD), undergoing irregular dialysis sessions, who presented with multiple swellings along the extensor surfaces of large joints of body including shoulders, sacrum, wrists and elbows. The swellings were initially painless, but later became painful on movements alone, were causing hindrance in movement and the sacral lump was causing difficulty in lying supine. On evaluation by laboratory investigations, he revealed borderline hyperphosphatemia and hypocalcemia...
August 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Luca Denaro, Alessandra Berton, Mauro Ciuffreda, Mattia Loppini, Vincenzo Candela, Maria Luisa Brandi, Umile Giuseppe Longo
CONTEXT: Chordomas are rare primary tumors of bone characterized by local aggressiveness and poor prognosis. The surgical exeresis plays a critical role for their management. OBJECTIVE: The aim was to provide an overview of the surgical management of chordomas of the mobile spine and sacrum, describing the most common surgical approaches, the role of surgical margins, the difficulties of en block resection, the outcomes of surgery, the recurrence rate and the use of associated therapies...
July 26, 2018: Journal of Spinal Cord Medicine
Spencer Summers, Jean Jose, Carlos M Barrera, Juan Pretell-Mazzini, Ty Subhawong, Nguyen V Nguyen, Darcy Kerr, G Petur Nielsen, Andrew E Rosenberg
Background and purpose Sacral intraosseous schwannomas represent a rare subset of schwannomas. The existing literature detailing the radiographic appearance of intraosseous schwannomas is limited. The aim of this study is to formally characterize the radiological appearance of sacral intraosseous schwannomas to differentiate them from other lytic lesions. Materials and methods Imaging studies of 13 pathologically proven intraosseous schwannomas were reviewed from multiple institutions by fellowship-trained radiologists...
October 2018: Neuroradiology Journal
L H Gong, W F Liu, Y Ding, W Zhang, Y K Yang, F Yu, G Q Wong, X Y Huang, X H Niu
Objective: To investigate the radiological and histopathological features of giant cell tumor of bone treated with RANKL inhibitor denosumab. Methods: Eleven cases were retrieved from the surgical pathology records between March 2015 and June 2017 in Beijing Jishuitan Hospital. Formalin fixed, paraffin embedded specimens were collected and the histological features were evaluated. The imaging features including X ray, magnetic resonance imaging, and computed tomography were also reviewed. Results: These 11 cases of giant cell tumor of bone were derived from five female and six male patients, with age ranged from 20 to 62 years (mean age, 35 years)...
June 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
S Pillai, S Govender
Chordoma is a rare malignant tumor with predilection for the sacrum. A favorable outcome depends on early diagnosis and surgical excision with tumor free margins. Aim: To review the incidence and prevalence of sacral chordoma and the appropriate surgical management and formulate a criteria for early diagnosis. Materials and methods: Thirty eight articles on the subject of sacral chordoma and extrapolated data of clinical and surgical significance. Results: The commonest presenting feature in patients with sacral chordoma was lower back pain which was worse on sitting and up to a third of these patients had associated urinary tract infections, constipation or symptoms of disc herniation...
June 2018: Journal of Orthopaedics
Junqiang Yin, Hui Wu, Jian Tu, Changye Zou, Gang Huang, Xianbiao Xie, Yulong He, Jingnan Shen
BACKGROUND: Few studies have been done on robot-assisted sacral surgery. This study aims to evaluate the outcomes of seven patients with benign sacral or presacral tumors treated with a robotic surgical system at a single center. METHODS: All patients with benign sacral or presacral tumors who underwent transperitoneal resection (between June 2015 and June 2016) using the da Vinci Si HD robotic surgical system (Intuitive Surgical Inc.) were included in this retrospective study...
June 6, 2018: BMC Musculoskeletal Disorders
Xiaohui Li, Rugang Lu, Youcai Zhao, Feng Wang, Guoqiang Shao
Primary malignant pericardial mesothelioma (PMPM) is an aggressive tumor that originates from the mesothelial cells of the pericardium. PMPM with extensive atrial infiltration and bone metastasis is extremely rare. The diagnosis and staging of PMPM based on anatomical imaging may be difficult when concurrent pericardial and pleural effusions are present. A 28-year-old man presented with progressive chest pain. Concurrent pericardial and pleural effusions were identified on computed tomography. On echocardiography, mild thickening and adhesions of the pericardium with the right ventricle and atrium were observed...
June 2018: Molecular and Clinical Oncology
Akio Sakamoto, Iori Nagamatsu, Eisuke Shiba, Takeshi Okamoto, Masanori Hisaoka, Shuichi Matsuda
Presacral myelolipomas are rare, benign, asymptomatic tumors composed of mature adipose tissue and hematopoietic elements. Presacral myelolipomas can occur in patients with a medical history of malignancy, steroid use, and/or endocrine disorders including diabetes mellitus. A 65-year-old man with no specific medical history experienced temporal abdominal pain without bowel symptoms that lasted a few hours. By the time he visited a hospital, the pain had diminished. Computed tomography failed to detect any abnormality in the abdominal or pelvic organs that would have caused the abdominal pain but revealed a lesion 4 cm in diameter in the frontal sacrum...
2018: Rare Tumors
Hui-Hui Sun, Xin Hong, Bing Liu, Jia-Qu Cui, Zhao-Ming Zhou, Xin-Hui Xie, Xiao-Tao Wu
This study was aimed to analyze the survival of patients with spinal chordomas. Patients' data in the Surveillance, Epidemiology, and End Results (SEER) database were retrieved and analyzed statistically. There were 765 patients with spinal chordomas between 1974 and 2013. The overall survival did not improve significantly over decades for patients receiving surgery and radiotherapy (SR) (P = 0.221). There were significant differences in overall survival among subgroups of patients receiving surgery (S), radiotherapy (R), and neither S nor R (NSR) (P = 0...
May 7, 2018: Neurosurgical Review
Tochukwu Ikpeze, Addisu Mesfin
Background: Chordomas are rare malignant primary tumors of the spine. In the mobile spine and sacrum an en-bloc resection is associated with decreased rates of recurrence. Our objective was to identify the top cited articles in chordoma research and to further analyze characteristics of these articles. Methods: In March 2017, we used ISI Web of Science (v5.11, Thomas Reuter, Philadelphia, Pennsylvania, USA) to search for the following key word: "chordoma"...
March 2018: Journal of Spine Surgery (Hong Kong)
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