keyword
https://read.qxmd.com/read/38528316/chemical-profiling-and-antioxidant-antimicrobial-and-hemolytic-properties-of-euphorbia-calyptrata-l-essential-oils-in-vitro-and-in-silico-analysis
#21
JOURNAL ARTICLE
Fatima El Kamari, Otmane Zouirech, Amira Metouekel, Mohammed Bouslamti, Imane Maliki, Abdelfattah El Moussaoui, Mohamed Chebaibi, Mohamed Taibi, Abdulaziz Abdullah Alsahli, Hiba-Allah Nafidi, Mohammed Bourhia, Musaab Dauelbait, Abdelfattah Abdellaoui
In this work, we sought to validate the use of Euphorbia calyptrata (L.), a Saharan and Mediterranean medicinal plant, in traditional pharmacopeia. GC-MS/MS identified volatile compounds of potential therapeutic interest. Antioxidant tests were performed using β-carotene decolorization, DPPH radical scavenging, FRAP, beta-carotene bleaching, and TAC. The antimicrobial activity was evaluated on solid and liquid media for bacterial and fungal strains to determine the zone of inhibition and the minimum growth concentration (MIC) of the microbes tested...
March 25, 2024: ChemistryOpen
https://read.qxmd.com/read/38527573/anti-inflammatory-effects-and-related-mechanisms-in-vitro-and-in-vivo-of-hedychium-coccineum-rhizome-essential-oil
#22
JOURNAL ARTICLE
Minyi Tian, Dan Xie, Yi Hong, Furong Ding, Xia Wu, Dongxin Tang
ETHNOPHARMACOLOGICAL RELEVANCE: Hedychium coccineum rhizome is an anti-inflammatory ethnomedicine used to remedy inflammation-related swelling and bronchial asthma. AIM OF THE STUDY: The study aimed to analyze the phytochemical constituents of H. coccineum rhizome essential oil (EO) and evaluate its in vitro and in vivo anti-inflammatory effects and underlying mechanisms. MATERIALS AND METHODS: Phytochemical constituents of H. coccineum rhizome EO were analyzed using GC-FID/MS...
March 23, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38527559/reassessing-the-role-of-phytochemicals-in-cancer-chemoprevention
#23
REVIEW
Gian Luigi Russo, Carmela Spagnuolo, Maria Russo
In this comprehensive review we tried to reassess the role of phytochemicals in cancer chemoprevention. The exploration of the "synergistic effect" concept, advocating combined chemopreventive agents, faces challenges like low bioavailability. The review incorporates personal, occasionally controversial, viewpoints on natural compounds' cancer preventive capabilities, delving into mechanisms. Prioritizing significant contributions within the vast research domain, we aim stimulating discussion to provide a comprehensive insight into the evolving role of phytochemicals in cancer prevention...
March 23, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38527165/neuromodulatory-effects-induced-by-the-association-of-moringa-oleifera-lam-tribulus-terrestris-l-undaria-pinnatidifida-extracts-in-the-hypothalamus
#24
JOURNAL ARTICLE
Annalisa Chiavaroli, Simonetta Cristina Di Simone, Alessandra Acquaviva, Nilofar Nilofar, Maria Loreta Libero, Luigi Brunetti, Lucia Recinella, Sheila Leone, Giustino Orlando, Gokhan Zengin, Maura Di Vito, Luigi Menghini, Claudio Ferrante
The present study investigated the role of a commercial formulation constituted by herbal extracts from Rhodiola rosea, Undaria pinnatifida, Tribulus terrestris, and Moringa oleifera. The formulation was analysed for determining the content in total phenols and flavonoids and scavenging/reducing properties. The formulation was also tested on isolated mouse hypothalamus in order to investigate effects on serotonin, dopamine, neuropeptide Y (NPY), and orexin A. The gene expression of gonadrotopin releasing hormone (GnRH) was also assayed...
March 25, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38527045/oral-administration-of-phytochemicals-protects-honey-bees-against-cognitive-and-motor-impairments-induced-by-the-insecticide-fipronil
#25
JOURNAL ARTICLE
Lina M García, Valentina Caicedo-Garzón, Andre J Riveros
Pollution produced by exposure to pesticides is a major concern for food security because the negative impacts on pollinators. Fipronil, an insecticide broadly used around the globe has been associated with the ongoing decline of bees. With a characteristic neuroactive toxicodynamic, fipronil leads to cognitive and motor impairments at sublethal dosages. Despite of regional bans, multilevel strategies are necessary for the protection of pollinators. Recent evidence suggests that specific nutrients in the diets of bees may induce protection against insecticides...
2024: PloS One
https://read.qxmd.com/read/38526821/steamed-daylily-flower-hemerocallis-fulva-l-protected-cardiac-and-hepatic-cells-against-ethanol-induced-apoptotic-and-oxidative-damage
#26
JOURNAL ARTICLE
Sheng-Lei Yan, Wen-Tzu Wu, Mei-Chin Mong, Mei-Chin Yin
Our previous study examined the phytochemical composition and bio-activities of raw daylily flower (Hemerocallis fulva L.). However, this plant food is usually served via heat process such as cooking in a soup. This study aimed to investigate the phytochemical profile and biofunctions of steamed daylily flower (SDF). The content of total phenolic acids, total flavonoids, total carotenoids, total anthocyanins and total triterpenoids in SDF aqueous extract was assessed. Normal cardiac and hepatic cells, H9c2 and L-02 cells, were used to evaluate the protective effects of SDF against ethanol...
December 15, 2023: Journal of Food and Drug Analysis
https://read.qxmd.com/read/38526663/chromatographic-fingerprinting-of-cacao-pod-husk-extracts-theobroma-cacao-l-exploring-antibacterial-antioxidant-and-antidiabetic-properties-with-in-silico-molecular-docking-analysis
#27
JOURNAL ARTICLE
Hany M Abd El-Lateef, Mai M Khalaf, Manal F Abou Taleb, Mohamed Gouda
Natural drugs derived from plants are becoming more popular because of their apparent biological efficacy, affordability, and safety. A byproduct of cocoa farms, cocoa pod husk (CPH), is often disregarded yet contains an abundance of phenolic chemicals that have antimicrobial and antioxidant features, which has led to intensive investigation into possible biomedical applications. In order to identify crucial functional groups and phytochemical components, we carefully examined the 80% ethanol and dichloromethane extracts of CPH using gas chromatography-mass spectrometry (GC-MS) and HPLC...
March 25, 2024: Applied Biochemistry and Biotechnology
https://read.qxmd.com/read/38526661/molecular-identification-and-phytochemical-analysis-and-bioactivity-assessment-of-catharanthus-roseus%C3%A2-leaf-extract-exploring-antioxidant-potential-and-antimicrobial-activities
#28
JOURNAL ARTICLE
Velusamy Arulvendhan, Periyakali Saravana Bhavan, Rajapandian Rajaganesh
Plants have long been at the main focus of the medical industry's attention due to their extensive list of biological and therapeutic properties and ethnobotanical applications. Catharanthus roseus, sometimes referred to as Nithyakalyani in Tamil, is an Apocynaceae family member used in traditional Indian medicine. It also examines the plant's potential antimicrobial and antioxidant activities as well as its preliminary phytochemical makeup. Leaf material from C. roseus was analyzed and found to include a variety of phytochemicals including alkaloids, terpenoids, flavonoids, tannins, phenols, saponins, glycosides, quinones, and steroids...
March 25, 2024: Applied Biochemistry and Biotechnology
https://read.qxmd.com/read/38525928/phytotherapeutic-potential-of-compounds-identified-from-fractionated-extracts-of-morus-alba-l-as-an-inhibitor-of-interleukin-6-in-the-treatment-of-rheumatoid-arthritis-computational-approach
#29
JOURNAL ARTICLE
Tran Nhat Phong Dao, Sunday Amos Onikanni, Adewale Oluwaseun Fadaka, Nicole Remaliah Samantha Sibuyi, Minh Hoang Le, Hen-Hong Chang
The presence of HLA-DRB1 alleles that encode critical points associated with environmental interactions is associated with increased risk of rheumatoid arthritis caused by anti-citrullinated protein antibodies. Therefore, interleukin-6 (IL-6), a multifunctional cytokine that controls both local and systemic acute inflammatory responses through its ability to induce a phase response, plays a serious role. Its overexpression leads to pathological challenges such as rheumatoid arthritis and menopausal osteoporosis...
March 25, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38525925/boosting-immune-responses-in-lung-tumor-immune-microenvironment-a-comprehensive-review-of-strategies-and-adjuvants
#30
REVIEW
Fei Gao, Xiaoqing You, Liu Yang, Xiangni Zou, Bowen Sui
The immune system has a substantial impact on the growth and expansion of lung malignancies. Immune cells are encompassed by a stroma comprising an extracellular matrix (ECM) and different cells like stromal cells, which are known as the tumor immune microenvironment (TIME). TME is marked by the presence of immunosuppressive factors, which inhibit the function of immune cells and expand tumor growth. In recent years, numerous strategies and adjuvants have been developed to extend immune responses in the TIME, to improve the efficacy of immunotherapy...
March 25, 2024: International Reviews of Immunology
https://read.qxmd.com/read/38525044/perspective-on-utilization-of-bacillus-species-as-plant-probiotics-for-different-crops-in-adverse-conditions
#31
REVIEW
Shubhra Singh, Douglas J H Shyu
Plant probiotic bacteria are a versatile group of bacteria isolated from different environmental sources to improve plant productivity and immunity. The potential of plant probiotic-based formulations is successfully seen as growth enhancement in economically important plants. For instance, endophytic Bacillus species acted as plant growth-promoting bacteria, influenced crops such as cowpea and lady's finger, and increased phytochemicals in crops such as high antioxidant content in tomato fruits. The present review aims to summarize the studies of Bacillus species retaining probiotic properties and compare them with the conventional fertilizers on the market...
2024: AIMS Microbiology
https://read.qxmd.com/read/38524936/biomarkers-and-signaling-pathways-of-diabetic-nephropathy-and-peripheral-neuropathy-possible-therapeutic-intervention-of-rutin-and-quercetin
#32
REVIEW
Tamsheel Fatima Roohi, Seema Mehdi, Sadaf Aarfi, K L Krishna, Suman Pathak, Seikh Mohammad Suhail, Syed Faizan
Diabetic nephropathy and peripheral neuropathy are the two main complications of chronic diabetes that contribute to high morbidity and mortality. These conditions are characterized by the dysregulation of multiple molecular signaling pathways and the presence of specific biomarkers such as inflammatory cytokines, indicators of oxidative stress, and components of the renin-angiotensin system. In this review, we systematically collected and collated the relevant information from MEDLINE, EMBASE, ELSEVIER, PUBMED, GOOGLE, WEB OF SCIENCE, and SCOPUS databases...
April 2024: Diabetology International
https://read.qxmd.com/read/38524627/climate-and-soil-factors-co-derive-the-functional-traits-variations-in-naturalized-downy-thorn-apple-datura-innoxia-mill-along-the-altitudinal-gradient-in-the-semi-arid-environment
#33
JOURNAL ARTICLE
Nasrullah Khan, Rafi Ullah, Mohammad K Okla, Mostafa A Abdel-Maksoud, Ibrahim A Saleh, Hashem A Abu-Harirah, Tareq Nayef AlRamadneh, Hamada AbdElgawad
Plant functional traits are consistently linked with certain ecological factors (i.e., abiotic and biotic), determining which components of a plant species pool are assembled into local communities. In this sense, non-native naturalized plants show more plasticity of morphological traits by adopting new habitat (an ecological niche) of the invaded habitats. This study focuses on the biomass allocation pattern and consistent traits-environment linkages of a naturalized Datura innoxia plant population along the elevation gradient in NW, Pakistan...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38524534/plant-extract-preparation-and-green-synthesis-of-silver-nanoparticles-using-swertia-chirata-characterization-and-antimicrobial-activity-against-selected-human-pathogens
#34
JOURNAL ARTICLE
Muhammad Adnan Shereen, Aftab Ahmad, Hashir Khan, Sadia Mehmood Satti, Abeer Kazmi, Nadia Bashir, Muhammad Shehroz, Shahid Hussain, Muhammad Ilyas, M Ijaz Khan, Hatoon A Niyazi, Ferjeni Zouidi
Herbal medicinal plants have been used for centuries in traditional medicine, and it is interesting to see how modern research has identified the active compounds responsible for their therapeutic effects. The green synthesis of silver nanoparticles using herbal medicinal plants, such as Swertia chirata , is particularly noteworthy due to its antimicrobial properties. In the current study, the Swertia chirata plant was collected for the first time from the region of Murree, Punjab, Pakistan. After collection, extracts were prepared in different solvents (ethanol, methanol, chloroform, and distilled water), and silver nanoparticles were synthesized by reducing silver nitrate (AgNO3 )...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38522945/comprehensive-insights-into-rheumatoid-arthritis-pathophysiology-current-therapies-and-herbal-alternatives-for-effective-disease-management
#35
REVIEW
Amrita Chatterjee, Monisha Jayaprakasan, Anirban Kr Chakrabarty, Naga Rajiv Lakkaniga, Bibhuti Nath Bhatt, Dipankar Banerjee, Avinash Narwaria, Chandra Kant Katiyar, Sunil Kumar Dubey
Rheumatoid arthritis is a chronic autoimmune inflammatory disease characterized by immune response overexpression, causing pain and swelling in the synovial joints. This condition is caused by auto-reactive antibodies that attack self-antigens due to their incapacity to distinguish between self and foreign molecules. Dysregulated activity within numerous signalling and immunological pathways supports the disease's development and progression, elevating its complexity. While current treatments provide some alleviation, their effectiveness is accompanied by a variety of adverse effects that are inherent in conventional medications...
March 24, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38522560/overexpression-of-tocopherol-biosynthesis-genes-in-guayule-parthenium-argentatum-reduces-rubber-resin-and-argentatins-content-in-stem-and-leaf-tissues
#36
JOURNAL ARTICLE
Grisel Ponciano, Niu Dong, Chen Dong, Andrew Breksa, Ana Vilches, Maha T Abutokaikah, Colleen McMahan, F Omar Holguin
Natural rubber produced in stems of the guayule plant (Parthenium argentatum) is susceptible to post-harvest degradation from microbial or thermo-oxidative processes, especially once stems are chipped. As a result, the time from harvest to extraction must be minimized to recover high quality rubber, especially in warm summer months. Tocopherols are natural antioxidants produced in plants through the shikimate and methyl-erythtiol-4-phosphate (MEP) pathways. We hypothesized that increased in vivo guayule tocopherol content might protect rubber from post-harvest degradation, and/or allow reduced use of chemical antioxidants during the extraction process...
March 22, 2024: Phytochemistry
https://read.qxmd.com/read/38522297/nanoencapsulation-of-hybrid-crude-palm-oil-unau%C3%A3-hie-oxg-with-jackfruit-by-products-as-encapsulants-a-study-of-cellular-antioxidant-activity-and-cytotoxicity-in-caco-2-cells
#37
JOURNAL ARTICLE
Larissa Santos Assunção, Camila Duarte Ferreira Ribeiro, Carolina Oliveira de Souza, Renan Danielski, Sarika Kumari, Itaciara Larroza Nunes, Fereidoon Shahidi
Hybrid crude palm oil (HCPO) HIE OxG is notable for its abundance of carotenoids, tocopherols, and tocotrienols. Investigating cellular antioxidant activity (CAA) and the non-cytotoxicity of oil nanoparticles is crucial for understanding the behavior of these phytochemicals in biological systems and ensuring the safety of products. Nanoparticles of HCPO, encapsulated with jackfruit by-products were produced and characterized for CAA and cytotoxicity in Caco-2 cells. The nanoparticles exhibited nanoscale diameters (<250 nm), uniform distribution and stability (polydispersity index < 0...
March 15, 2024: Food Chemistry
https://read.qxmd.com/read/38521495/proliferacorins-a-m-thirteen-undescribed-acorane-sesquiterpenoids-isolated-from-the-fungus-fusarium-proliferatum
#38
JOURNAL ARTICLE
Alan Bao, Qin Li, Xiaotian Zhang, Meijia Zheng, Nanjin Ding, Chunmei Chen, Yonghui Zhang, Hucheng Zhu
In this study, 13 previously undescribed acorane sesquiterpenoids, namely, proliferacorins A-M, were isolated from the solid fermentation of Fusarium proliferatum. Their structures and absolute configurations were confirmed via spectroscopic analyses, quantum-chemical NMR calculations with DP4+ probability analyses, ECD calculations and comparisons, and single-crystal X-ray diffraction techniques. Proliferacorins A-E (1-5) have a 7-oxa-tricyclo[6.3.1.01,5 ]tridecane decorated with a rare ether bridge between C-7 and C-11, while proliferacorin F (6) possesses a 7-oxa-tricyclic[6...
March 21, 2024: Phytochemistry
https://read.qxmd.com/read/38521364/pharmacological-effects-of-methysticin-and-l-sulforaphane-through-the-nrf2-are-signaling-pathway-in-mlo-y4-osteocytes-in-vitro-study
#39
JOURNAL ARTICLE
Maja Charlotte Dittmar, Mersedeh Tohidnezhad, Athanassios Fragoulis, Annette Bücker, Matthias Stein, Thomas Pufe, Yusuke Kubo
BACKGROUND: Oxidative stress plays a crucial role in the pathogenesis of many skeletal diseases by inducing osteocyte death. The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator of various antioxidant gene expressions through antioxidant response element (ARE) against cellular oxidative stress and can be induced by various stimulants, including the phytochemicals Methysticin (MET) and L-Sulforaphane (SFN). This study aimed to establish an osteocyte in vitro model to investigate the pharmacological effects of MET and SFN on the Nrf2/ARE pathway...
March 21, 2024: Annals of Anatomy
https://read.qxmd.com/read/38520787/deciphering-jak-stat-signaling-pathway-a-multifaceted-approach-to-tumorigenesis-progression-and-therapeutic-interventions
#40
REVIEW
Yihui Wang, Zhe Wang, Shuyu Li, Juntao Ma, Xiaoshuo Dai, Jing Lu
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway, essential for cellular communication, orchestrates a myriad of physiological and pathological processes. Recently, the intricate association between the pathway's dysregulation and the progression of malignant tumors has garnered increasing attention. Nevertheless, there is no systematic summary detailing the anticancer effects of molecules targeting the JAK/STAT pathway in the context of tumor progression. This review offers a comprehensive overview of pharmaceutical agents targeting the JAK/STAT pathway, encompassing phytochemicals, synthetic drugs, and biomolecules...
March 22, 2024: International Immunopharmacology
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