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https://www.readbyqxmd.com/read/29682442/green-synthesis-of-nerium-oleander-conjugated-gold-nanoparticles-and-study-of-its-in-vitro-anticancer-activity-on-mcf-7-cell-lines-and-catalytic-activity
#1
Abir Chandan Barai, Koushik Paul, Aditi Dey, Subhankar Manna, Somenath Roy, Braja Gopal Bag, Chiradeep Mukhopadhyay
The phytochemicals present in the stem bark extract of Nerium oleander (commonly known as Karabi) have been utilized for the green synthesis of stable gold-conjugated nanoparticles at room temperature under very mild conditions. The green synthesized gold-conjugated nanoparticles were characterized by surface plasmon resonance spectroscopy, High resolution transmission electron microscopy, X-ray diffraction studies and dynamic light scattering. A mechanism for the synthesis and stabilization of gold-conjugated nanoparticles (AuNPs) has been proposed...
2018: Nano Convergence
https://www.readbyqxmd.com/read/29681982/propolin-c-inhibited-migration-and-invasion-via-suppression-of-egfr-mediated-epithelial-to-mesenchymal-transition-in-human-lung-cancer-cells
#2
Jih-Tung Pai, Yi-Chin Lee, Si-Ying Chen, Yann-Lii Leu, Meng-Shih Weng
Controlling lung cancer cell migration and invasion via epithelial-to-mesenchymal transition (EMT) through the regulation of epidermal growth factor receptor (EGFR) signaling pathway has been demonstrated. Searching biological active phytochemicals to repress EGFR-regulated EMT might prevent lung cancer progression. Propolis has been used as folk medicine in many countries and possesses anti-inflammatory, antioxidant, and anticancer activities. In this study, the antimigration and anti-invasion activities of propolin C, a c-prenylflavanone from Taiwanese propolis, were investigated on EGFR-regulated EMT signaling pathway...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29681978/flavonoids-effects-on-hepatocellular-carcinoma-in-murine-models-a-systematic-review
#3
REVIEW
Estefanny Ruiz García, Eliana Alviárez Gutierrez, Fabiana Cristina Silveira Alves de Melo, Rômulo Dias Novaes, Reggiani Vilela Gonçalves
The hepatocellular carcinoma (HCC) is the second most common cause of cancer deaths worldwide. It occurs primarily as manifestation of other pathological processes, such as viral hepatitis, cirrhosis, and toxin exposure that affect directly the cellular process. Studies were selected from PubMed and Scopus databases according to the PRISMA statement. The research filters were constructed using three parameters: flavonoids, hepatocellular carcinoma, and animal model. The bias analysis of the 34 selected works was done using the ARRIVE guidelines...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29681972/-in-vitro-bioactivity-of-methanolic-extracts-from-amphipterygium-adstringens-schltdl-schiede-ex-standl-chenopodium-ambrosioides-l-cirsium-mexicanum-dc-eryngium-carlinae-f-delaroche-and-pithecellobium-dulce-roxb-benth-used-in-traditional-medicine-in-mexico
#4
Peter Knauth, Gustavo J Acevedo-Hernández, M Eduardo Cano, Melesio Gutiérrez-Lomelí, Zaira López
Seven out of eight methanolic extracts from five plants native to Mexico were inactive against ten bacterial strains of clinical interest. The fruit extract of Chenopodium ambrosioides inhibited the bacteria Enterococcus faecalis (MIC = 4375  μ g/ml), Escherichia coli (MIC = 1094  μ g/ml), and Salmonella typhimurium (MIC = 137  μ g/ml). The fruit extract of C. ambrosioides was with CC50 = 45  μ g/ml most cytotoxic against the cell-line Caco-2, followed by the leaf extract from Pithecellobium dulce (CC50 = 126  μ g/ml); interestingly, leaves of C...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29681854/evidence-supports-tradition-the-in-vitro-effects-of-roman-chamomile-on-smooth-muscles
#5
Zsolt Sándor, Javad Mottaghipisheh, Katalin Veres, Judit Hohmann, Tímea Bencsik, Attila Horváth, Dezső Kelemen, Róbert Papp, Loránd Barthó, Dezső Csupor
The dried flowers of Chamaemelum nobile (L.) All. have been used in traditional medicine for different conditions related to the spasm of the gastrointestinal system. However, there have been no experimental studies to support the smooth muscle relaxant effect of this plant. The aim of our research was to assess the effects of the hydroethanolic extract of Roman chamomile, its fractions, four of its flavonoids (apigenin, luteolin, hispidulin, and eupafolin), and its essential oil on smooth muscles. The phytochemical compositions of the extract and its fractions were characterized and quantified by HPLC-DAD, the essential oil was characterized by GC and GC-MS...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29680063/effects-of-high-humidity-hot-air-impingement-blanching-hhaib-pretreatment-on-the-change-of-antioxidant-capacity-the-degradation-kinetics-of-red-pigment-ascorbic-acid-in-dehydrated-red-peppers-during-storage
#6
Jun Wang, Xu-Hai Yang, Arun S Mujumdar, Xiao-Ming Fang, Qian Zhang, Zhi-An Zheng, Zhen-Jiang Gao, Hong-Wei Xiao
Effect of high-humidity hot air impingement blanching on photochemical degradation kinetics (red pigments and ascorbic acid) and antioxidant capacity changes (2,2-diphenyl-1-picrylhydracyl, DPPH and total antioxidant capacity) of red pepper during 6-month storage at ambient temperature in dark was investigated. Ultrastructure of raw and blanched samples was also observed using a transmission electron microscope (TEM). Blanching followed by drying resulted in 63-85% and 33-59% reduction in red pigment and ascorbic acid content, respectively...
September 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29680032/antioxidant-polyphenols-of-madeira-sorrel-rumex-maderensis-how-do-they-survive-to-in-vitro-simulated-gastrointestinal-digestion
#7
Vítor Spínola, Eulogio J Llorent-Martínez, Paula C Castilho
In this work, we report the phytochemical profile and antioxidant activity of different morphological parts of Rumex maderensis Lowe (Polygonaceae), a wild leafy-vegetable growing in Madeira Island (Portugal). Methanol extracts from leaves, flowers, and stems were submitted to high-performance liquid chromatography with mass spectrometry detection to obtain the phytochemical profile, which allowed the identification of 86 polyphenols (about 70% C- and O-flavonoids) and 9 non-phenolic compounds. In vitro antioxidant activities were measured against ABTS, DPPH, nitric oxide and superoxide free radicals...
September 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29679184/hplc-dad-identification-of-polyphenols-from-ethyl-acetate-extract-of-amaranthus-spinosus-leaves-and-determination-of-their-antioxidant-and-antinociceptive-effects
#8
Ilhem Rjeibi, Anouar Ben Saad, Jazia Sdayria, Anouar Feriani, Sana Ncib, Mohamed Salah Allagui, Najla Hfaiedh, Sami Souid
Amaranthus spinosus has been consumed traditionally to prevent various diseases including abdominal pain. In this study, the phytochemical composition, antioxidant and analgesic activities of an ethyl acetate extract of A. spinosus leaves (ASEA) were evaluated. The ASEA had the highest concentrations of total phenols (462.2 mg GAE/g DW), condensed tannin (5.01 mg CE/g DW) and total flavonoid contents (30.07 mg CE/g DW) compared to the chloroform, n-hexane, n-butanol and water extracts. Similarly, ASEA showed the most effective total antioxidant activity (45...
April 20, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29677459/hepatoprotective-and-antioxidant-properties-of-the-aqueous-extract-of-olea-europaea-leaves-against-diclofenac-induced-liver-damages-in-mice
#9
Rawya Soussi, Najla Hfaiedh, Fatma Guesmi, Mohsen Sakly, Khémais Ben Rhouma
Historically, olive tree "Olea europaea" is one of the most important fruit trees in Mediterranean countries. Several studies suggest that olive leaf is a significant source of bioactive phenolic compounds compared to olive oil and fruits. This study was undertaken to investigate, the protective effect of the aqueous extract of « Chemlali » olive leaves against diclofenac-induced damages in liver and haematological alterations in swiss albinos mice. For this, twenty-eight mice were divided into four groups: a control group, a diclofenac-treated group (2...
April 20, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29676912/bioactivity-guided-isolation-of-potential-antidiabetic-and-antihyperlipidemic-compounds-from-trigonella-stellata
#10
Safa M Shams Eldin, Mohamed M Radwan, Amira S Wanas, Abdel-Azim M Habib, Fahima F Kassem, Hala M Hammoda, Shabana I Khan, Michael L Klein, Khaled M Elokely, Mahmoud A ElSohly
The in vitro antidiabetic and antihyperlipidemic activities of an alcoholic extract of Trigonella stellata were evaluated in terms of the activation of PPARα and PPARγ in human hepatoma (HepG2) cells. The extract was investigated phytochemically, aiming at the isolation of the most active compounds to be used as a platform for drug discovery. Three new isoflavans, (3 S,4 R)-4,2',4'-trihydroxy)-7-methoxyisoflavan (1), (3 R,4 S)-4,2',4'-trihydroxy-7-methoxy-4'- O-β-d-glucopyranosylisoflavan (2), and (2 S,3 R,4 R)-4,2',4'-trihydroxy-2,7-dimethoxyisoflavan (3), were isolated and characterized along with the five known compounds p-hydroxybenzoic acid (4), 7,4'-dihydroxyflavone (5), dihydromelilotoside (6), quercetin-3,7- O-α-l-dirhamnoside (7), and soyasaponin I (8)...
April 20, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29676124/-four-new-cis-phenylethanoid-glycosides-from-stems-of-cistanche-deserticola-cultured-in-tarim-desert
#11
Ze-Dong Nan, Hua-Zhong Ren, Ming-Bo Zhao, Yong Jiang, Peng-Fei Tu
In order to clarify the chemical constituents of Cistanche deserticola cultured in Tarim desert, a systematically phytochemical investigation was carried out. The chemical constituents were isolated by column chromatography, such as silica gel, Sephadex LH-20, MCI gel, ODS and semi-preparative HPLC, and their structures were determined on the basis of MS, NMR spectroscopic analysis, and comparison with literature data. Four compounds were isolated from the 85% ethanol extract of the stems of C. cultured in Tarim desert...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29676097/-quality-evaluation-of-artemisiae-argyi-folium-based-on-fingerprint-analysis-and-quantitative-analysis-of-multicomponents
#12
Long Guo, Qian Jiao, Dan Zhang, Ai-Peng Liu, Qian Wang, Yu-Guang Zheng
Artemisiae Argyi Folium, the dried leaves of Artemisia argyi, has been widely used in traditional Chinese and folk medicines for treatment of hemorrhage, pain, and skin itch. Phytochemical studies indicated that volatile oil, organic acid and flavonoids were the main bioactive components in Artemisiae Argyi Folium. Compared to the volatile compounds, the research of nonvolatile compounds in Artemisiae Argyi Folium are limited. In the present study, an accurate and reliable fingerprint approach was developed using HPLC for quality control of Artemisiae Argyi Folium...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29675806/comparative-study-of-predominant-phytochemical-compounds-and-proapoptotic-potential-of-broccoli-sprouts-and-florets
#13
Paweł Paśko, Małgorzata Tyszka-Czochara, Agnieszka Galanty, Joanna Gdula-Argasińska, Paweł Żmudzki, Henryk Bartoń, Paweł Zagrodzki, Shela Gorinstein
The study compares lyophilized broccoli sprouts and florets in terms of their chemical composition, cytotoxic and proapoptotic potential against hepatocellular carcinoma HepG2, colorectal cancer SW480, and skin fibroblast BJ cells. Sinapic and isochlorogenic acids were predominant phenolics in the sprouts and florets, respectively. The amount of sulforaphane in the sprouts was significantly higher vs. florets. Oleic and linoleic acids dominated in the sprouts, while caproic, stearic and oleic acids in the florets...
April 19, 2018: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/29674278/cassia-grandis-fruit-extract-reduces-the-blood-glucose-level-in-alloxan-induced-diabetic-rats
#14
Ariadna Lafourcade Prada, Jesús Rafael Rodríguez Amado, Hady Keita, Edgar Puente Zapata, Helison Carvalho, Emersom Silva Lima, Tatiane Pereira de Sousa, José Carlos Tavares Carvalho
INTRODUCTION: Cassia grandis Lf fruits are ethnobotanically used for digestive disorders, anemia, and for reducing blood glucose. However, there are no studies about the antidiabetic activity nor the oral toxicity of the plant fruit-extracts. This paper aims to evaluate the hypoglycemic effect of C. grandis fruits extract in vivo, and assess the acute oral toxicity, and sub-acute oral toxicity. The antioxidant activity and the α-glycosidase inhibitor effect were also evaluated. METHODS: The extract was obtained by maceration of the fruit pulp with 70% hydroalcoholic solution (1:2, m:v)...
April 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29672977/phytotherapeutics-in-cancer-invasion-and-metastasis
#15
REVIEW
Bahare Salehi, Paolo Zucca, Mehdi Sharifi-Rad, Raffaele Pezzani, Sadegh Rajabi, William N Setzer, Elena Maria Varoni, Marcello Iriti, Farzad Kobarfard, Javad Sharifi-Rad
Cancer is a multifactorial disease, and therefore, a multitarget approach is needed to face the complex cancer biology, based on the combined use of different natural and synthetic anticancer agents able to target synergistically multiple signaling pathways involved in carcinogenesis, including angiogenesis and metastasis. In this view, the plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. This narrative review aims to provide an updated overview on the bioactive phytochemicals exhibiting a promising potential as adjuvants in conventional anticancer therapies, with emphasis on antiangiogenic and antimetastatic activities...
April 19, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29672923/dual-role-of-par-4-in-abrogation-of-emt-and-switching-on-mesenchymal-to-epithelial-transition-met-in-metastatic-pancreatic-cancer-cells
#16
Archana Katoch, Sujit Suklabaidya, Souneek Chakraborty, Debasis Nayak, Reyaz Ur Rasool, Deepak Sharma, Debaraj Mukherjee, Mir Mohd Faheem, Anmol Kumar, Parduman Raj Sharma, Shantibhusan Senapati, Lekha Dinesh Kumar, Anindya Goswami
Epithelial-mesenchymal transition (EMT), a critical event that occurs during invasion and metastatic spread of cancer cells. Here, we conceive a dual mechanism of Par-4-mediated inhibition of EMT and induction of MET in metastatic pancreatic cancer cells. First, we demonstrate that 1,1'-β-D-glucopyranosyl-3,3'-bis(5-bromoindolyl)-octyl methane (NGD16), an N-glycosylated derivative of medicinally important phytochemical 3,3'-diindolylmethane (DIM) abrogates EMT by inducing pro-apoptotic protein Par-4. Induction of Par-4 (by NGD16 or ectopic overexpression) strongly impedes invasion with inhibition of major mesenchymal markers viz...
April 19, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29672819/isolation-and-determination-of-phenolic-glycosides-and-anthraquinones-from-rhizomes-of-various-reynoutria-species
#17
Izabela Nawrot-Hadzik, Sebastian Granica, Krzysztof Domaradzki, Łukasz Pecio, Adam Matkowski
Giant knotweeds of the genus Reynoutria (syn. Fallopia )- Reynoutria japonica, Reynoutria sachalinensis , and a hybrid of them, Reynoutria x bohemica -are noxious invasive plants in Europe and North America. R. japonica is a traditional East Asian (Japan and China) drug ( Polygoni cuspidati rhizoma ). Recently, it has been included in European Pharmacopoeia as one of the traditional Chinese medicinal herbs. In this study, a reversed-phase high performance liquid chromatography method with diode array detector and time-of-flight mass spectrometry was developed and validated for the profiling of rhizomes from European invasive populations and Polygoni cuspidati rhizoma purchased in China...
April 19, 2018: Planta Medica
https://www.readbyqxmd.com/read/29672044/andrographolide-antagonizes-tnf-%C3%AE-induced-il-8-via-inhibition-of-nadph-oxidase-ros-nf-%C3%AE%C2%BAb-and-src-mapks-ap-1-axis-in-human-colorectal-cancer-hct116-cells
#18
Miaomiao Yuan, Wei Meng, Wenzhen Liao, Sen Lian
Andrographis paniculata Nees is used as a functional food in Japan, Korea, India and China. Andrographolide, a naturally occurring phytochemical identified in Andrographis paniculata, has been discovered to present anti-inflammatory and anticancer activities. Highly expressed of interleukin (IL-8) has been detected in colorectal cancer and is implicated in angiogenesis. However, the effect and molecular mechanisms of IL-8 expression by andrographolide remain obscure in human colorectal cancer cells. The present study was aimed to investigate the effects of andrographolide on TNF-α-induced IL-8 expression and its underlying mechanisms...
April 19, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29671907/a-comprehensive-review-of-phytochemical-profile-bioactives-for-pharmaceuticals-and-pharmacological-attributes-of-azadirachta-indica
#19
REVIEW
Sumaira Saleem, Gulzar Muhammad, Muhammad Ajaz Hussain, Syed Nasir Abbas Bukhari
Azadirachta indica L. is a multipurpose medicinal tree of family Meliaceae. It occurs in tropical and semitropical regions of the world. Different parts of this miraculous tree are used to treat pyrexia, headache, ulcer, respiratory disorders, cancer, diabetes, leprosy, malaria, dengue, chicken pox, and dermal complications. The tree is popular for its pharmacological attributes such as hypolipidemic, antifertility, microbicidal, antidiabetic, anti-inflammatory, hepatoprotective, antipyretic, hypoglycemic, insecticidal, nematicidal, antiulcer, antioxidant, neuroprotective, cardioprotective, and antileishmaniasis properties...
April 19, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29671794/phytochemical-study-of-the-ecuadorian-species-lepechinia-mutica-benth-epling-and-high-antifungal-activity-of-carnosol-against-pyricularia-oryzae
#20
Jorge Ramírez, Gianluca Gilardoni, Erika Ramón, Solveig Tosi, Anna Maria Picco, Carlo Bicchi, Giovanni Vidari
The plant Lepechinia mutica (Benth.) Epling (family Lamiaceae) is endemic to Ecuador. In the present study, we report some major non-volatile secondary metabolites from the leaves and the chemistry of the essential oil distilled from the flowers. The main identified compounds were carnosol, viridiflorol, ursolic acid, oleanolic acid, chrysothol, and 5-hydroxy-4′,7-dimethoxy flavone. Their structures were determined by X-ray diffraction and NMR and MS techniques. The essential oil showed a chemical composition similar to that distilled from the leaves, but with some qualitative and quantitative differences regarding several minor compounds...
April 19, 2018: Pharmaceuticals
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