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Phytochemical

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https://www.readbyqxmd.com/read/28732430/bee-pollen-flavonoids-as-a-therapeutic-agent-in-allergic-and-immunological-disorders
#1
Masoomeh Jannesar, Maryam Sharif Shoushtari, Ahmad Majd, Zahra Pourpak
Bee pollen grains, as the male reproductive part of seed-bearing plants contain considerable concentrations of various phytochemicals and nutrients. Since antiquity, people throughout the world used pollens to cure colds, flu, ulcers, premature aging, anemia and colitis. It is now well-documented that some bee pollen secondary metabolites (e.g. flavonoid) may have positive health effects. In recent years, the flavonoids have attracted much interest because of their wide range of biological properties and their beneficial effects on human health...
June 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28731316/phytochemical-analysis-of-myrtus-communis-plant-conventional-versus-microwave-assisted-extraction-procedures
#2
Nadia Bouaoudia-Madi, Lila Boulekbache-Makhlouf, Nabil Kadri, Farid Dahmoune, Hocine Remini, Sofiane Dairi, Sonia Oukhmanou-Bensidhoum, Khodir Madani
Background Myrtle (Myrtus communis L) may constitute an interesting dietary source of health protective compounds. Microwave-assisted extraction (MAE) of total phenolic compounds (TPC) from myrtle leaf, stems, pericarp, and seeds was studied and the results were compared with those of the conventional method extraction (CME) in terms of extraction time. Methods Extraction yield/efficiency and antioxidant activity were measured using radical scavenging assay (DPPH•) and reducing power. Results The results show that the MAE was higher in terms of saving energy, extraction time (62 s) and extraction efficiency of bioactive compound compared to CME (2 h)...
June 10, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28730384/verifying-identities-of-plant-based-multivitamins-using-phytochemical-fingerprinting-in-combination-with-multiple-bioassays
#3
Yeni Lim, Yoon Hee Ahn, Jae Keun Yoo, Kyoung Sik Park, Oran Kwon
Sales of multivitamins have been growing rapidly and the concept of natural multivitamin, plant-based multivitamin, or both has been introduced in the market, leading consumers to anticipate additional health benefits from phytochemicals that accompany the vitamins. However, the lack of labeling requirements might lead to fraudulent claims. Therefore, the objective of this study was to develop a strategy to verify identity of plant-based multivitamins. Phytochemical fingerprinting was used to discriminate identities...
July 20, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/28729705/diterpenoid-alkaloids-from-delphinium-anthriscifolium-var-majus
#4
Lian-Hai Shan, Ji-Fa Zhang, Feng Gao, Shuai Huang, Xian-Li Zhou
Extensive phytochemical investigation on the whole herbs of Delphinium anthriscifolium var. majus led to the identification of fourteen diterpenoid alkaloids, including three new C20-diterpenoid alkaloids (anthriscifolsines A-C, 1-3), six new C19-diterpenoid alkaloids (anthriscifolrines A-F, 4-9), and five know compounds (10-14). Among them, anthriscifolsine A represents a novel C20-diterpenoid alkaloid characterized by a seco C-ring. The structures of the isolated compounds were elucidated by extensive spectroscopic methods, including HR-ESI-MS, X-ray, and 1D and 2D NMR experiments...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28725898/the-effect-of-selected-food-phytochemicals-on-breast-cancer-metastasis-based-on-in-vivo-capture-of-circulating-tumor-cells
#5
Chuanchen Wu, Zhaochen Liu, Zhen Zhang, Yuehua Jiang, Hongyan Zhang
The number of circulating tumor cells (CTCs) in a mouse tumor model fed with different dietary factors was first evaluated by in vivo CTC capture at different time points of cancer progression. The results showed that the number of CTCs reflected the degree of cancer progression. A new assessment method of dietary factor effects on cancer metastasis was established.
July 20, 2017: Food & Function
https://www.readbyqxmd.com/read/28725625/evaluation-of-effect-of-alcoholic-extract-of-heartwood-of-pterocarpus-marsupium-on-in%C3%A2-vitro-antioxidant-anti-glycation-sorbitol-accumulation-and-inhibition-of-aldose-reductase-activity
#6
Pankaj Gupta, Vivek Jain, Ashutosh Pareek, Preeti Kumari, Randhir Singh, Priyanka Agarwal, Veena Sharma
Rising popularity of phytomedicines in various diseased conditions have strengthened the significance of plant-research and evaluation of phytoextracts in clinical manifestations. Pterocarpus marsupium Roxb., a medicinal plant, known for its anti-oxidant and anti-diabetic activity is a rich source of phytochemicals with antihyperglycemic and antihyperlipidemic activities. However, its possible role in diabetic complications is not evaluated yet. The present study explores the possible role of alcoholic extract of heartwood of P...
July 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28725148/isolation-biological-evaluation-and-validated-hptlc-quantification-of-the-marker-constituent-of-the-edible-saudi-plant-sisymbrium-irio-l
#7
Shaza M Al-Massarani, Ali A El Gamal, Perwez Alam, Ebtesam S Al-Sheddi, Mai M Al-Oqail, Nida N Farshori
Phytochemical investigation and chromatographic purification of the n-hexane fraction of the aerial parts of the edible Saudi plant Sisymbrium irio led to the isolation of β-sitosterol (1), stigmasterol (2) and β-sitosterol-β-d-glucoside (3). The cytotoxic effects of the n-hexane, dichloromethane, ethyl acetate and n-butanol fractions were tested against three cancer cell lines viz., MCF-7, HCT-116 and HepG2, using the crystal violet staining (CVS) method, while the antibacterial activity against a number of pathogenic bacterial strains, was also estimated using the broth microdilution assay...
July 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28724201/variations-in-the-bioactive-compounds-composition-and-biological-activities-of-loofah-luffa-cylindrica-fruits-in-relation-to-maturation-stages
#8
Takoua Ben Hlel, Feten Belhadj, Fatih Gül, Muhammed Altun, Ayşe ŞahinYağlıoğlu, Ibrahim Demirtaş, M Nejib Marzouki
The present work aimed to determine the antioxidant and antiproliferative potential of Luffa cylindrica fruits collected at two different maturation stages and to identify and compare their functional components composition. The methanolic extracts of L. cylindrica fruits harvested at 60 to 65 days after seeding (S1) and 85 to 90 days after seeding (S2) were investigated for their antioxidant activity using various assays. Furthermore, the antiproliferative activity of the extracts against HeLa human cervical cancer cells was explored with xCELLigence real time cell analyzer while the effect of the samples on the membrane integrity of the same cell line was assessed using LDH cytotoxicity leakage assay...
July 19, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28723868/screening-of-medicinal-plant-phytochemicals-as-natural-antagonists-of-p53-mdm2-interaction-to-reactivate-p53-functioning
#9
Muhammad Riaz, Usman A Ashfaq, Muhammad Qasim, Erum Yasmeen, Muhammad T Ul Qamar, Farooq Anwar
In most types of cancer, overexpression of murine double minute 2 (MDM2) often leads to inactivation of p53. The crystal structure of MDM2, with a 109-residue amino-terminal domain, reveals that MDM2 has a core hydrophobic region to which p53 binds as an amphipathic α helix. The interface depends on the steric complementarity between MDM2 and the hydrophobic region of p53. Especially, on p53's triad, amino acids Phe19, Trp23 and Leu26 bind to the MDM2 core. Results from studies suggest that the structural motif of both p53 and MDM2 can be attributed to similarities in the amphipathic α helix...
July 18, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28722505/lipolytic-effect-of-compounds-isolated-from-leaves-of-mulberry-morus-alba-l-in-3t3-l1-adipocytes
#10
Hong Xu Li, Eunji Jo, Chang-Seon Myung, Young Ho Kim, Seo Young Yang
In this study, 19 known compounds were isolated from mulberry (Morus alba L.) leaves. The lipid accumulation inhibitory activity of the isolated compounds was investigated. Compounds 4 and 12 showed good anti-adipogenic activity based on 3T3-L1 adipocytes with values of 36.6 ± 9.0 and 34.7 ± 4.0%, respectively. In addition, compounds 3, 6 and 15 showed significant inhibitory activity with values from 15.4 to 21.2% and compounds 2, 8-9 and 17-18 exhibited weak activity with values ranging from 2.1 to 10...
July 19, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28722156/chemometric-evaluation-of-hypericin-and-related-phytochemicals-in-17-in-vitro-cultured-hypericum-species-hairy-root-cultures-and-hairy-root-derived-transgenic-plants
#11
Katarína Nigutová, Souvik Kusari, Selahaddin Sezgin, Linda Petijová, Jana Henzelyová, Miroslava Bálintová, Michael Spiteller, Eva Čellárová
OBJECTIVES: The objective of this study was to ascertain the presence and correlations among eight important secondary metabolites viz. hypericin, pseudohypericin, emodin, hyperforin, rutin, hyperoside, quercetin and quercitrin in different organs of 17 in vitro cultured Hypericum species, along with H. tomentosum and H. tetrapterum hairy root cultures, and hairy root-derived transgenic plants of H. tomentosum. METHODS: Samples were extracted and analysed by LC-MS...
July 19, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28721833/role-of-nutrients-and-phyto-compounds-in-the-modulation-of-antimicrobial-resistance
#12
Steve Harakeh, Imran Khan, Saad B Almasaudi, Esam I Azhar, Soad Al-Jaouni, Aleksandra Niedzweicki
Antimicrobial resistance is quickly spreading and has become a major public health problem worldwide. If this issue is not resolved, it may cause a shift back to the pre-antibiotics era and infectious disease will again be a serious problem, especially in developing countries. Since the discovery of antibiotics, bacterial resistance has emerged, enabling certain bacteria to withstand antibiotic effects. The emergence of antibiotic resistance is fueled by excessive and improper use of antimicrobial agents, especially in developing countries...
July 18, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28721679/phytochemicals-as-potential-antidotes-for-targeting-nf-%C3%AE%C2%BAb-in-rheumatoid-arthritis
#13
REVIEW
R Kowshik Aravilli, S Laveen Vikram, V Kohila
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune destructive arthropathy prevalent among people in the age group of 40-70 years. RA induces severe pain, swelling and stiffness of joints resulting in bone damage. RA leads to reduced life expectancy when left untreated. RA is characterized by synovial hyperplasia, infiltration of inflammatory cells resulting in formation of pannus. Synovial hyperplasia is mediated by proinflammatory cytokines, notably IL-1 and TNF-α. NF-κB is a predominant transcription factor in amplifying the inflammatory response...
August 2017: 3 Biotech
https://www.readbyqxmd.com/read/28720941/chemical-composition-and-bioactivity-of-essential-oils-from-flower-and-fruit-of-thymbra-capitata-and-thymus-species
#14
Jonathan Delgado-Adámez, María Garrido, Maria Elena Bote, María C Fuentes-Pérez, Javier Espino, Daniel Martín-Vertedor
Thymbra capitata and Thymus species are commonly known as thyme in Spain and they are currently used as culinary herbs, as well as for ornamental, aromatizing and traditional medicinal purposes. Given the economic importance of thyme oils, many thyme species have been studied, and their essential oils (EOs) and other volatile-containing extracts have been chemically characterized. The aim of this study was to evaluate the antioxidant, antimicrobial and cytotoxic activities as well as the phytochemical composition of the EOs from fruits and flowers of T...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28720131/anti-arthritic-activity-of-aqueous-methanolic-extract-and-various-fractions-of-berberis-orthobotrys-bien-ex-aitch
#15
Alamgeer, Ambreen Malik Uttra, Umme Habiba Hasan
BACKGROUND: The roots and stem bark of Berberis orthobotrys (Berberidaceae) have long been used traditionally to treat joint pain. Though, it has not been pharmacologically assessed for rheumatoid arthritis. The current study explores anti-arthritic activity and phytochemical analysis of aqueous-methanolic extract (30:70) and fractions (ethyl acetate, n-butanol, and aqueous) of Berberis orthobotrys roots. METHODS: Anti-arthritic potential was evaluated in vitro using protein denaturation (bovine serum albumin and egg albumin) and membrane stabilization methods at 12...
July 18, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28719999/comparison-of-anticancer-activity-of-biocompatible-zno-nanoparticles-prepared-by-solution-combustion-synthesis-using-aqueous-leaf-extracts-of-abutilon-indicum-melia-azedarach-and-indigofera-tinctoria-as-biofuels
#16
G K Prashanth, P A Prashanth, B M Nagabhushana, S Ananda, G M Krishnaiah, H G Nagendra, H M Sathyananda, C Rajendra Singh, S Yogisha, S Anand, Y Tejabhiram
Recently, there has been an upsurge in the use of naturally available fuels for solution combustion synthesis (SCS) of nanoparticles. Although many reports suggest that these biofuels pose less harm to the environment, their strategic advantages and reliability for making NPs has not been discussed. In the present work, we try to address this issue using plant extracts as biofuels for the SCS of zinc oxide nanoparticles as a model system. In the present work, combustion synthesis of ZnO NPs using lactose and aqueous leaf extracts of Abutilon indicum, Melia azedarach, Indigofera tinctoria as biofuels has been carried out...
July 18, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28716565/mangiferin-a-phytochemical-with-panacea-potential
#17
EDITORIAL
Abdur Rauf, Muhammad Imranb, Seema Patel
No abstract text is available yet for this article.
July 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28716411/genetic-mitigation-strategies-to-tackle-agricultural-ghg-emissions-the-case-for-biological-nitrification-inhibition-technology
#18
REVIEW
G V Subbarao, J Arango, K Masahiro, A M Hooper, T Yoshihashi, Y Ando, K Nakahara, S Deshpande, I Ortiz-Monasterio, M Ishitani, M Peters, N Chirinda, L Wollenberg, J C Lata, B Gerard, S Tobita, I M Rao, H J Braun, V Kommerell, J Tohme, M Iwanaga
Accelerated soil-nitrifier activity and rapid nitrification are the cause of declining nitrogen-use efficiency (NUE) and enhanced nitrous oxide (N2O) emissions from farming. Biological nitrification inhibition (BNI) is the ability of certain plant roots to suppress soil-nitrifier activity, through production and release of nitrification inhibitors. The power of phytochemicals with BNI-function needs to be harnessed to control soil-nitrifier activity and improve nitrogen-cycling in agricultural systems. Transformative biological technologies designed for genetic mitigation are needed, so that BNI-enabled crop-livestock and cropping systems can rein in soil-nitrifier activity, to help reduce greenhouse gas (GHG) emissions and globally make farming nitrogen efficient and less harmful to environment...
September 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28714318/gc-ms-analysis-of-the-bioactive-phytoconstituents-of-various-organic-crude-extracts-from-the-seed-kernels-of-manilkara-bidentata-balata-collected-in-trinidad-w-i
#19
Yomica L Powder-George, Faisal K Mohammed
The present study reports the first phytochemical investigation of the seed kernels of Manilkara bidentata (Balata) harvested in Trinidad, W.I. Gas chromatography-mass spectrometry (GC-MS) analysis of the n-hexane, chloroform, ethyl acetate, ethanol and methanol extracts showed a total of 39 components. 2,6,10,14,18-pentamethyl-2,6,10,14,18-eicosapentaene (74.93%), 9-octadecenoic acid, (Z)- 2,3-dihydroxypropyl ester (79.98%), (Z)-ethyl oleate (92.75%), Z,E-2-methyl-3,13-octadecadien-1-ol (80.51%) and 5-(hydroxymethyl)-2-furancarboxyaldehyde (50...
July 16, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28713892/trichostatin%C3%A2-a-induces-bladder-cancer-cell-death-via-intrinsic-apoptosis-at-the-early%C3%A2-phase-and-sp1%C3%A2-survivin-downregulation-at-the-late%C3%A2-phase-of-treatment
#20
Shou-Chieh Wang, Shou-Tsung Wang, Hung-Te Liu, Xiang-Yu Wang, She-Ching Wu, Lei-Chin Chen, Yi-Wen Liu
Histone deacetylase (HDAC) inhibitors have been widely shown to result in cancer cell death. The present study investigated the mechanisms underlying the antitumor effects of the phytochemical trichostatin A (TSA), a classic pan-HDAC inhibitor, in 5,637 urinary bladder cancer cells. It was found that TSA caused cell cycle arrest at the G2/M and G1 phase accompanied by reduced expression of cyclin D1 and upregulated induction of p21. In addition, TSA induced morphological changes, reduced cell viability and apoptotic cell death in 5,637 cells through caspase-3 activation followed by PARP cleavage...
July 6, 2017: Oncology Reports
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