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Cornea keratoconus refractive

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https://www.readbyqxmd.com/read/29118708/corneal-collagen-cross-linking-combined-with-an-artiflex-iris-fixated-anterior-chamber-phakic-intraocular-lens-implantation-in-a-patient-with-progressive-keratoconus
#1
Sharif Hashmani, Nauman Hashmani, Roha Saeed Memon
We present here the case of a 24-year-old male who experienced progressive keratoconus and vision loss which adversely affected his ability to carry out everyday tasks. This landed him in the Hashmanis Hospital for consultation. He had a preoperative best corrected visual acuity of 6/12. He underwent multiple Oculus Pentacam examinations, which showed progressive keratoconus. Corneal collagen cross-linking (CXL) was performed to stabilize his cornea and, subsequently, an Artiflex anterior chamber iris-fixated phakic intraocular lens (ACIF-PIOL) was implanted to alleviate his refractive errors...
September 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29116549/transepithelial-accelerated-corneal-collagen-cross-linking-with-higher-oxygen-availability-for-keratoconus-1-year-results
#2
Ling Sun, Meng Li, Xiaoyu Zhang, Mi Tian, Tian Han, Jing Zhao, Xingtao Zhou
PURPOSE: To investigate the safety and efficacy of a new protocol for transepithelial accelerated corneal collagen cross-linking with higher oxygen availability for keratoconus treatment. METHODS: There were 26 patients (26 eyes) diagnosed with keratoconus enrolled in the study and treated with transepithelial accelerated corneal collagen cross-linking. The corneas were irradiated using UVA light for 5 min and 20 s with 45 mW/cm(2) irradiance and pulsed illumination (1:1)...
November 7, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29103962/corneal-stroma-enhancement-with-decellularized-stromal-laminas-with-or-without-stem-cell-recellularization-for-advanced-keratoconus
#3
Jorge L Alió Del Barrio, Mona El Zarif, Albert Azaar, Nehman Makdissy, Charbel Khalil, Walid Harb, Ibrahim El Achkar, Ziad Abdul Jawad, María P de Miguel, Jorge L Alió
PURPOSE: Phase-1 study to preliminarily evaluate the safety and efficacy of decellularized human corneal stromal lamina transplantation with or without autologous adipose derived adult stem cells (ADASC) recellularization within the corneal stroma of patients with advanced keratoconus. DESIGN: Phase one clinical trial METHODS: Femtosecond-assisted 120μm-thickness and 9mm-diameter laminas were obtained from the anterior stroma of human donor corneas and decellularized with a sodium dodecyl sulfate solution...
November 2, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29042747/high-resolution-wavefront-guided-surface-ablation-with-corneal-cross-linking-in-ectatic-corneas-a-pilot-study
#4
Gustavo E Tamayo, Claudia Castell, Pilar Vargas, Eduardo Polania, Juliana Tamayo
PURPOSE: A preliminary study to evaluate the outcomes of high-resolution wavefront-guided (HRWG) photorefractive keratectomy (PRK) with simultaneous corneal cross-linking (CXL) in ectasia eyes. METHODS: Sixteen eyes of 11 patients (mean age 31.9±9.8 years; range: 15-48 years) with keratoconus or post-laser-assisted in situ keratomileusis ectasia underwent HRWG PRK with simultaneous CXL. Manifest refraction, uncorrected (UDVA) and corrected distance visual acuity (CDVA), and keratometric and aberrometric outcomes are reported at 12 months...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28969170/comparison-of-central-corneal-thickness-using-anterior-segment-optical-coherence-tomography-versus-ultrasound-pachymetry
#5
Prasanna Venkatesh Ramesh, Kirti Nath Jha, Krishnagopal Srikanth
INTRODUCTION: Corneal thickness is an important and sensitive indicator of corneal health. It is useful in monitoring corneal diseases such as corneal oedema and keratoconus, and selecting patients for refractive surgery. Central Corneal Thickness (CCT) is a risk factor for Primary Open-Angle Glaucoma (POAG). AIM: To compare CCT using ultrasound pachymetry and Anterior Segment Optical Coherence Tomography (AS-OCT), and also to find out the reproducibility of AS-OCT readings for both central and pericentral corneal areas...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28932339/penetrating-keratoplasty-for-keratoconus-excimer-versus-femtosecond-laser-trephination
#6
Berthold Seitz, Achim Langenbucher, Tobias Hager, Edgar Janunts, Moatasem El-Husseiny, Nora Szentmáry
BACKGROUND: In case of keratoconus, rigid gas-permeable contact lenses as the correction method of first choice allow for a good visual acuity for quite some time. In a severe stage of the disease with major cone-shaped protrusion of the cornea, even specially designed keratoconus contact lenses are no more tolerated. In case of existing contraindications for intrastromal ring segments, corneal transplantation typically has a very good prognosis. METHODS: In case of advanced keratoconus - especially after corneal hydrops due to rupture of Descemet's membrane - penetrating keratoplasty (PKP) still is the surgical method of first choice...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28913504/a-review-and-meta-analysis-of-corneal-cross-linking-for-post-laser-vision-correction-ectasia
#7
REVIEW
Qi Wan, Dan Wang, HongQuan Ye, Jing Tang, Yu Han
PURPOSE: The aim of this study was to review the safety and stability of cornea cross-linking (CXL) for the treatment of keratectasia after Excimer Laser Refractive Surgery. METHODS: Eligible studies were identified by systematically searching PubMed, Embase, Web of Science and reference lists. Meta-analysis was performed using Stata 12.1 software. The primary outcome parameters included the changes of corrected distant visual acuity (CDVA), uncorrected visual acuity (UCVA), the maximum keratometry value (Kmax) and minimum keratometry value (Kmin), the surface regularity index (SRI), the surface asymmetry index (SAI), the keratoconus prediction index (KPI), corneal thickness, and endothelial cell count...
September 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28726533/ophthalmic-findings-in-patients-with-arterial-tortuosity-syndrome-and-carriers-a-case-series
#8
Joshua S Hardin, Yuri A Zarate, Bert Callewaert, Paul H Phillips, David B Warner
INTRODUCTION: Arterial tortuosity syndrome (ATS) is a rare autosomal recessive disease hallmarked by tortuosity, stenosis, and aneurysm development of large- and medium-sized arteries. Mutations in SLC2A10, a gene that encodes the facilitative glucose transporter GLUT10, cause ATS. Several case reports have noted associated ophthalmic findings such as keratoconus, keratoglobus, and myopia without detailed descriptions or standardized examinations. We report the ophthalmic findings in a cohort of compound heterozygous ATS patients and heterozygous carriers of SLC2A10 mutations...
July 20, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28681909/medium-to-long-term-results-of-corneal-cross-linking-for-keratoconus-using-phototherapeutic-keratectomy-for-epithelial-removal-and-partial-stromal-ablation
#9
Xiangjun Chen, Aleksandar Stojanovic, Yangyang Xu, Wen Zhou, Sten Raeder, Sam Enayati, Tor Paaske Utheim
PURPOSE: To evaluate the medium- to long-term outcomes of corneal cross-linking in treatment of keratoconus using transepithelial phototherapeutic keratectomy (PTK-CXL) for epithelial removal and partial stromal ablation to stabilize the cornea, reduce corneal irregularity, and improve corrected vision. METHODS: Retrospective analysis of 46 keratoconic eyes that underwent PTK-CXL. Corrected distance visual acuity (CDVA), manifest refraction, steep and flat simulated keratometry (Kmax and Kmin), corneal irregularity index (IRI), corneal higher order aberrations (HOAs), epithelial thickness profile, and corneal biomechanical characteristics were evaluated preoperatively and postoperatively...
July 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28681902/integration-of-scheimpflug-based-corneal-tomography-and-biomechanical-assessments-for-enhancing-ectasia-detection
#10
Renato Ambrósio, Bernardo T Lopes, Fernando Faria-Correia, Marcella Q Salomão, Jens Bühren, Cynthia J Roberts, Ahmed Elsheikh, Riccardo Vinciguerra, Paolo Vinciguerra
PURPOSE: To present the Tomographic and Biomechanical Index (TBI), which combines Scheimpflugbased corneal tomography and biomechanics for enhancing ectasia detection. METHODS: Patients from different continents were retrospectively studied. The normal group included 1 eye randomly selected from 480 patients with normal corneas and the keratoconus group included 1 eye randomly selected from 204 patients with keratoconus. There were two groups: 72 ectatic eyes with no surgery from 94 patients with very asymmetric ectasia (VAE-E group) and the fellow eyes of these patients with normal topography (VAE-NT group)...
July 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28676992/topographic-typology-in-a-consecutive-series-of-refractive-surgery-candidates
#11
Seyed-Farzad Mohammadi, Vahid Mohammadzadeh, Sakineh Kadivar, Amir-Houshang Beheshtnejad, Amir Hossein Norooznezhad, Seyed-Hassan Hashemi
PURPOSE: The term 'keratoconus (KC) suspect' is used as a blanket term to refer to any deviation of virgin cornea shape toward KC features. We intend to subclassify such topographies in meaningful and informative designations. METHODS: Pentacam corneal topographies of 199 consecutive refractive surgery candidates (398 eyes) are examined. Features of steepness, inferior-superior asymmetry, focal steepening, thinning, and bounded anterior or posterior elevations are observed in the quad map...
July 4, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28658437/indications-and-visual-outcomes-of-intrastromal-corneal-ring-segment-implantation-in-a-large-patient-series
#12
Taíse Tognon, Mauro Campos, João Paulo Wengrzynovski, Kleyton Arlindo Barella, Adriano Pasqualotti, Luiz Antônio de Brito Martins, Adriana Dos Santos Forseto, Luciene Barbosa de Sousa
OBJECTIVES: To describe the indications for and visual outcomes of intrastromal corneal ring segment implantation. METHODS: A large retrospective case-series chart-review study was conducted using Sorocaba Ophthalmological Hospital medical records. This study included 1222 eyes (1196 patients) that were surgically treated between November 2009 and December 2012. The following preoperative data were collected: age, gender, type of medical care and funding source, surgical technique, best-corrected visual acuity, manifest sphere and cylinder refractive error, maximum and minimum central keratometry, and pachymetry measurements of the cornea at the thinnest point and at the ring channel...
June 2017: Clinics
https://www.readbyqxmd.com/read/28630786/ophthoselfie-detailed-self-imaging-of-cornea-and-anterior-segment-by-smartphone
#13
Abdullah Kaya
OBJECTIVES: To describe the ophthoselfie, a method by which everyone can take detailed self-images of the cornea and anterior segment with a smartphone. MATERIALS AND METHODS: A 90-diopter non-contact double aspheric lens was attached to posterior camera of the smartphone by clear tape. Images of one eye on the screen of the smartphone could be seen with the other eye in the mirror and images were taken. RESULTS: Accurate and detailed images of the cornea and anterior segment of the eye could be taken...
June 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28594648/risk-profiles-of-ectasia-after-keratorefractive-surgery
#14
Pushpanjali Giri, Dimitri T Azar
PURPOSE OF REVIEW: To identify and evaluate the risk factors of iatrogenic ectasia after refractive surgery. RECENT FINDINGS: We reviewed recently published papers that identified various risk factors associated with ectasia after LASIK, photorefractive keratectomy, small incision lenticule extraction, and other refractive surgical procedures. We also attempted to evaluate the relative contributions of these factors to the development of ectasia following refractive surgery...
July 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28549842/mitochondrial-dysfunction-and-oxidative-stress-in-corneal-disease
#15
Neeru A Vallabh, Vito Romano, Colin E Willoughby
The cornea is the anterior transparent surface and the main refracting structure of the eye. Mitochondrial dysfunction and oxidative stress are implicated in the pathogenesis of inherited (e.g. Kearns Sayre Syndrome) and acquired corneal diseases (e.g. keratoconus and Fuchs endothelial corneal dystrophy). Both antioxidants and reactive oxygen species are found in the healthy cornea. There is increasing evidence of imbalance in the oxidative balance and mitochondrial function in the cornea in disease states...
May 23, 2017: Mitochondrion
https://www.readbyqxmd.com/read/28546941/role-of-corneal-collagen-fibrils-in-corneal-disorders-and-related-pathological-conditions
#16
REVIEW
Hong-Yan Zhou, Yan Cao, Jie Wu, Wen-Song Zhang
The cornea is a soft tissue located at the front of the eye with the principal function of transmitting and refracting light rays to precisely sense visual information. Corneal shape, refraction, and stromal stiffness are to a large part determined by corneal fibrils, the arrangements of which define the corneal cells and their functional behaviour. However, the modality and alignment of native corneal collagen lamellae are altered in various corneal pathological states such as infection, injury, keratoconus, corneal scar formation, and keratoprosthesis...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28486719/customized-topography-guided-corneal-collagen-cross-linking-for-keratoconus
#17
Myriam Cassagne, Kévin Pierné, Stéphane D Galiacy, Marie-Pierre Asfaux-Marfaing, Pierre Fournié, François Malecaze
PURPOSE: To compare the efficacy and safety of topography-guided corneal collagen cross-linking (TG-CXL) to conventional corneal CXL (C-CXL) in progressive keratoconus. METHODS: In this prospective, nonrandomized clinical trial, 60 eyes of 60 patients were scheduled to receive either TG-CXL (30 eyes with deepithelialization focused on the cone, riboflavin application for 10 minutes, and 30 mW/cm(2) pulsed ultraviolet-A irradiance pattern according to topography) or C-CXL (30 eyes treated in accordance with the Dresden protocol)...
May 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28426715/acute-hypoxia-influences-collagen-and-matrix-metalloproteinase-expression-by-human-keratoconus-cells-in-vitro
#18
Tina B McKay, Jesper Hjortdal, Shrestha Priyadarsini, Dimitrios Karamichos
Keratoconus (KC) is a progressive corneal ectasia linked to thinning of the central cornea. Hard contact lenses, rigid gas permeable lenses, and scleral lenses are the primary treatment modalities for early to mid- stages of KC to correct refractive error and astigmatism that develops as a result of an irregular corneal structure. These treatments are associated with significant drawbacks, including reduced availability of the tear film and oxygen to the corneal epithelium and stroma. However, it remains unknown whether hypoxia affects corneal integrity in the KC pathobiology...
2017: PloS One
https://www.readbyqxmd.com/read/28393023/mathematical-analysis-of-corneal-remodelling-after-intracorneal-ring-surgery-in-keratoconus
#19
Elias F Jarade, Elise Slim, Carole Cherfan, Hala El Rami, Toufic Hassan, Elias Chelala
AIM: To represent mathematically the intersection between the ectatic corneal geometry and the plane of intracorneal ring implants (ICRS) in order to determine the corneal response to ICRS surgery in keratoconus (KC). Thereafter, to present the concept and early results of a newly derived topography-guided nomogram for ICRS surgery for the treatment of keratectasia. METHODS: The corneal rings plane intersection was modelled to a conic section. Ring effect was the result of: the ring size, position (steep vs flat), location (distance from the geometric centre of the cornea), and the discrepancy between the ring's curvature and the tunnel's curvature...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28341606/safety-and-efficacy-of-sequential-intracorneal-ring-segment-implantation-and-cross-linking-in-pediatric-keratoconus
#20
Youssef Abdelmassih, Sylvain El-Khoury, Ali Dirani, Rafic Antonios, Ali Fadlallah, Carole G Cherfan, Elias Chelala, Elias F Jarade
PURPOSE: To evaluate the safety and visual outcome of intracorneal ring segment (ICRS) implantation followed by cross-linking in pediatric keratoconus patients. DESIGN: Retrospective interventional case series. METHODS: This retrospective study included pediatric patients (aged ≤14 years) with keratoconus and poor corrected distance visual acuity (CDVA) that underwent ICRS implantation and cross-linking (CXL). ICRS were inserted under topical anesthesia after creating a corneal tunnel with a femtosecond laser...
June 2017: American Journal of Ophthalmology
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