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Cornea keratoconus refractive

Natasha Pahuja, Nimisha R Kumar, Rushad Shroff, Rohit Shetty, Rudy M M A Nuijts, Anuprita Ghosh, Abhijit Sinha-Roy, Shyam S Chaurasia, Rajiv R Mohan, Arkasubhra Ghosh
Purpose: In this study, we elucidated the differential expression of a set of local molecular factors in ectatic cone area of the cornea to uncover a functional cause for focal corneal weakening characteristic of the keratoconus (KC) disease. Methods: All human corneal samples were collected after approval of Institutional Ethics Committee and informed consent. Keratoconus patients were classified based on clinical parameters, topographical features, and structural deformity...
October 1, 2016: Investigative Ophthalmology & Visual Science
Abdulrahman Darraj, Walid Barakat, Mona Kenani, Reem Shajry, Abdullah Khawaji, Sultan Bakri, Abdulrahman Makin, Azza Mohanna, Abu Obaida Yassin
BACKGROUND: The rise in childhood eye diseases has become a matter of concern in Saudi Arabia, and hence a study has been conducted on the residents of Jazan. The aim of the research was to find out the root cause of such issues and provide a solution to prevent such circumstances for it may affect the vision of children. In this study, therefore, we aimed to determine the types of childhood eye diseases in Jazan and to discuss the best ways to prevent them or prevent their effect on the vision of our children...
2016: Ophthalmology and Eye Diseases
Leonardo Torquetti, Carlos Arce, Jesús Merayo-Lloves, Guilherme Ferrara, Paulo Ferrara, Brenno Signorelli, Armando Signorelli
AIM: To evaluate corneal parameters measured with a dual Scheimpflug analyzer in keratoconus patients implanted with intrastromal corneal ring segments (ICRS). METHODS: Fifty eyes of 40 keratoconus patients had Ferrara ICRS implantation from November 2010 to April 2014. Uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), refraction, keratometry, asphericity, elevation, pachymetry, root mean square (RMS), spherical aberration and coma were studied...
2016: International Journal of Ophthalmology
S S Wei, Y Li, J Li, J G Liu, L Ye, Y Q Wan, J Li, J Du
Objective: To compare the corneal biomechanical properties of keratoconic and normal eyes, and to explore the changing characteristics in keratoconic eyes. Methods: Case-control study. Thirty-two keratoconic subjects(41 eyes)and 41 subjects(41 eyes)with normal corneas were enrolled in this study. Scheimpflug noncontact tonometry(Corvis ST)was performed to measure the length of Appl 1(1st A length), velocity of Appl 1(Vin), length of Appl 2(2nd A length), velocity of Appl 2(Vout), deformation amplitude(DA), peak distance, and radius...
September 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Leonardo Mastropasqua, Mario Nubile
PURPOSE: To investigate the feasibility of the procedure and the modifications of the corneal curvature and profile obtained with a novel technique of stromal-lentoid implantation in ex vivo human corneas. DESIGN: Experimental ex vivo study in human corneas. MATERIALS AND METHODS: Twelve stromal lentoids were produced by means of hyperopic femtosecond lenticule extraction (FLEx) with the VisuMax femtosecond laser (Carl Zeiss Meditec, Jena, Germany) with a refractive power of +8...
September 15, 2016: International Ophthalmology
Mehrdad Mohammadpour, Kazem Mohammad, Nasser Karimi
PURPOSE: To evaluate the agreement among Pentacam, Orbscan and ultrasound (US) pachymetry for measurement of central corneal thickness (CCT) in thin corneas with normal topographic pattern. METHODS: We included 88 eyes of 44 refractive surgery candidates with thinnest pachymetric readings of 500 micrometers (μm) or less on Orbscan, a normal topographic pattern, no sign of keratoconus, and best corrected visual acuity (BCVA) of 20/20. Pentacam, Orbscan and US were performed in one session by the same examiner...
July 2016: Journal of Ophthalmic & Vision Research
S H Chen, J Zhang, Y N Li, P Ding, Q M Wang
OBJECTIVE: To evaluate the effect of transepithelial corneal collagen cross-linking (CXL) in the treatment of keratoconus. METHODS: Prospective study. Sixteen eyes of 16 patients with keratoconus underwent transepithelial CXL, and the fellow eyes were considered as the controls. The mean age was (22.4±6.5) years old. In the CXL group, topical anesthesia (0.1% tetracaine) was given for 15 minutes, and 0.5% riboflavin was applied until saturated in the anterior chamber...
July 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Raffaella Mercatelli, Fulvio Ratto, Francesca Rossi, Francesca Tatini, Luca Menabuoni, Alex Malandrini, Riccardo Nicoletti, Roberto Pini, Francesco Saverio Pavone, Riccardo Cicchi
Keratoconus is an eye disorder that causes the cornea to take an abnormal conical shape, thus impairing its refractive functions and causing blindness. The late diagnosis of keratoconus is among the principal reasons for corneal surgical transplantation. This pathology is characterized by a reduced corneal stiffness in the region immediately below Bowman's membrane, probably due to a different lamellar organization, as suggested by previous studies. Here, the lamellar organization in this corneal region is characterized in three dimensions by means of second-harmonic generation (SHG) microscopy...
July 29, 2016: Journal of Biophotonics
Panida Kosrirukvongs, Panotsom Ngowyutagon, Wipawee Booranapong
OBJECTIVE: To show the association between keratoconus and macular dystrophy. MATERIAL AND METHOD: All patients with macular dystrophy and associated clinical findings leading to a diagnosis of keratoconus by corneal topography were retrospectively reviewed during a 10-year period. Uncorrected and best-corrected visual acuity, automated refraction, manifest refraction, corneal thickness, and corneal curvature by corneal topography were evaluated RESULTS: Three patients with macular dystrophy exhibiting decreased vision, multifocal white dense deposits, and haze surrounding the deposits in the corneal stroma were evaluated...
January 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Mehdi Shajari, Emanuel Eberhardt, Michael Müller, Ghada Al Khateeb, Stefan Friderich, Matthias Remy, Thomas Kohnen
PURPOSE: To evaluate the effects of atopic syndrome on manifestations of keratoconus. METHODS: In this retrospective study, we reviewed patient files and data generated by Scheimpflug imaging of 670 eyes of 434 keratoconus patients. Patients were divided into a study group consisting of patients suffering from atopic syndrome (110 eyes of 75 patients), namely allergic asthma, atopic dermatitis, and/or allergic rhinitis, and a control group of patients without known atopic syndrome (560 eyes of 359 patients)...
July 13, 2016: Cornea
Allan Luz, Bernardo Lopes, Katie M Hallahan, Bruno Valbon, Isaac Ramos, Fernando Faria-Correia, Paulo Schor, William J Dupps, Renato Ambrósio
PURPOSE: To evaluate the performance of the Ocular Response Analyzer (ORA) (Reichert Ophthalmic Instruments, Depew, NY) variables and Pentacam HR (Oculus Optikgeräte GmbH, Wetzlar, Germany) tomographic parameters in differentiating forme fruste keratoconus (FFKC) from normal corneas, and to assess a combined biomechanical and tomographic parameter to improve outcomes. METHODS: Seventy-six eyes of 76 normal patients and 21 eyes of 21 patients with FFKC were included in the study...
July 1, 2016: Journal of Refractive Surgery
Muhammet Bahattin Kır, Kemal Türkyılmaz, Veysi Öner
PURPOSE: To report 2-year outcomes of transepithelial high-intensity cross-linking (CXL) procedure in the treatment of patients with progressive keratoconus. METHODS: Forty-eight eyes of 48 consecutive progressive keratoconus patients who underwent transepithelial accelerated CXL procedure were enrolled in the study. Each patient underwent pre- and postoperative comprehensive ophthalmologic examinations including determination of refractive error as spherical equivalent (SE) and corrected distant visual acuity (CDVA), slit lamp biomicroscopic examination, fundoscopy, and a detailed analysis on a Scheimplug+Placido device (Sirius, CSO, Florence, Italy)...
June 1, 2016: Current Eye Research
Mohamed Shafik Shaheen, Ahmed Shalaby Bardan, David P Piñero, Hani Ezzeldin, Mohamed El-Kateb, Hany Helaly, Mounir A Khalifa
PURPOSE: To evaluate the clinical outcomes of wave front-guided (WFG) photorefractive keratectomy (PRK) using a high-definition aberrometer in corneas with keratoconus at least 1 year after corneal collagen cross-linking (CXL). METHODS: Prospective uncontrolled interventional case series study including a total of 34 consecutive eyes of 25 patients with keratoconus previously treated with CXL. All cases underwent WFG PRK using the VISX STAR S4 IR excimer laser and the iDesign system...
July 2016: Cornea
Sara Ortiz-Toquero, Guadalupe Rodriguez, Victoria de Juan, Raul Martin
PURPOSE: To determine and compare the repeatability of anterior corneal higher order aberrations (HOAs) using a Placido-based topographer (Allegro Topolyzer; WaveLight Technologie AG, Alcon Laboratories, Erlangen, Germany) in a sample of normal and keratoconic eyes. METHODS: Three repeated measurements of each cornea of normal and keratoconic eyes were taken with the Allegro Topolyzer. Repeatability of the HOAs (3rd- and 4th-order individual values and normalized polar Zernike coefficients, coma-like, root mean square (RMS) up to 8th-order values, HOA RMS, and total RMS for 6-mm pupil diameter) and central corneal power (3-mm pupil) were analyzed...
May 1, 2016: Journal of Refractive Surgery
Cosimo Mazzotta, Soosan Jacob, Amar Agarwal, Dhivya Ashok Kumar
PURPOSE: To study in vivo confocal microscopy (IVCM) after contact lens-assisted corneal collagen cross-linking (CACXL) in keratoconic eyes with thin corneas. METHODS: This prospective interventional case series included patients with progressive keratoconus with minimum corneal thickness less than 400 µm after removing epithelium. CACXL was done once functional corneal thickness was confirmed to be 400 µm or greater after applying a riboflavin-soaked, ultraviolet barrier-free contact lens...
May 1, 2016: Journal of Refractive Surgery
Marcony R Santhiago, Natalia T Giacomin, David Smadja, Samir J Bechara
This review outlines risk factors of post-laser in situ keratomileusis (LASIK) ectasia that can be detected preoperatively and presents a new metric to be considered in the detection of ectasia risk. Relevant factors in refractive surgery screening include the analysis of intrinsic biomechanical properties (information obtained from corneal topography/tomography and patient's age), as well as the analysis of alterable biomechanical properties (information obtained from the amount of tissue altered by surgery and the remaining load-bearing tissue)...
2016: Clinical Ophthalmology
Omid Hesami, Seyedeh Simindokht Hosseini, Nasim Kazemi, Seyed-Mostafa Hosseini-Zijoud, Nahid Beladi Moghaddam, Farhad Assarzadegan, Sara Mokhtari, Shahrzad Fakhraee
INTRODUCTION: Topiramate, a sulfa-derivative monosaccharide, is an antiepileptic drug which is administered in the control of migraine. It is reported to cause various ocular side effects such as visual field defect and myopic shift. To investigate the alterations in refractive error, properties of the cornea and changes in the anterior chamber in patients that receive Topiramate for migraine control. MATERIALS AND METHODS: This is a hospital-based, non-interventional, observational study that is conducted at Imam Hossein Hospital, affiliated to Shahid Beheshti University of Medical Sciences, Department of Neurology, in collaboration with the department of Ophthalmology...
March 2016: Journal of Clinical and Diagnostic Research: JCDR
Elan Rosenblat, Peter S Hersh
PURPOSE: To determine intraoperative changes in corneal thickness and outcomes of corneal collagen crosslinking (CXL) using 2 intraoperative regimens: riboflavin-dextran or hypotonic riboflavin. SETTING: Cornea and refractive surgery practice, Teaneck, New Jersey, USA. DESIGN: Prospective randomized case series. METHODS: Eyes with keratoconus or corneal ectasia were treated. All eyes received preloading with riboflavin 0...
April 2016: Journal of Cataract and Refractive Surgery
Hasan Razmjoo, Seyed Mohammad Ghoreishi, Alireza Ashtari, Iman Ghafouri, Bashir Mamousi
BACKGROUND: Corneal transplantation is a surgery in which cornea is replaced by a donated one and can be completely penetrating keratoplasty (PK) or included a part of cornea deep lamellar keratoplasty (DLK). Although the functional results are limited by some complications, it is considered as one of the most successful surgeries. This study aimed to compare the refractive errors after same size corneal transplantation through DLK and PK methods in keratoconus patients over 20 years...
2016: Advanced Biomedical Research
Ladan Espandar, Jonathan B Mandell, Sasan Niknam
OBJECTIVE: To assess the use of a new polygonal trephination pattern for deep anterior lamellar keratoplasty (DALK) assisted by femtosecond laser. DESIGN: Prospective, nonrandomized clinical study. METHODS: Twenty-four eyes underwent decagonal DALK. All except 1 had advanced keratoconus. A laser was used to create decagonal cuts on both donor and recipient corneas. All patients were assessed for uncorrected visual acuity, best spectacle-corrected visual acuity (BCVA), and keratometry by Pentacam pre- and postoperatively...
April 2016: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
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