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https://www.readbyqxmd.com/read/26590344/ran-translation-in-huntington-disease
#1
Monica Bañez-Coronel, Fatma Ayhan, Alex D Tarabochia, Tao Zu, Barbara A Perez, Solaleh Khoramian Tusi, Olga Pletnikova, David R Borchelt, Christopher A Ross, Russell L Margolis, Anthony T Yachnis, Juan C Troncoso, Laura P W Ranum
Huntington disease (HD) is caused by a CAG ⋅ CTG expansion in the huntingtin (HTT) gene. While most research has focused on the HTT polyGln-expansion protein, we demonstrate that four additional, novel, homopolymeric expansion proteins (polyAla, polySer, polyLeu, and polyCys) accumulate in HD human brains. These sense and antisense repeat-associated non-ATG (RAN) translation proteins accumulate most abundantly in brain regions with neuronal loss, microglial activation and apoptosis, including caudate/putamen, white matter, and, in juvenile-onset cases, also the cerebellum...
November 18, 2015: Neuron
https://www.readbyqxmd.com/read/17083328/identification-of-a-novel-nucleoside-triphosphatase-from-mycoplasma-mobile-a-prime-candidate-motor-for-gliding-motility
#2
Naoto Ohtani, Makoto Miyata
A protein with a molecular mass of 42 kDa (P42) from Mycoplasma mobile, one of several mycoplasmas that exhibit gliding motility, was shown to be a novel NTPase (nucleoside triphosphatase). Although the P42 protein lacks a common ATP-binding sequence motif (Walker A), the recombinant proteins expressed in Escherichia coli certainly hydrolysed some nucleoside triphosphates, including ATP. The results of photoaffinity labelling by an ATP analogue supported that the P42 protein contains a specific binding site for ATP (or another nucleoside triphosphate)...
April 1, 2007: Biochemical Journal
https://www.readbyqxmd.com/read/15766881/the-pst44-polycistronic-expression-system-for-producing-protein-complexes-in-escherichia-coli
#3
Song Tan, Ronald C Kern, William Selleck
Protein complexes are responsible for key biological processes, but methods to produce recombinant protein complexes for biochemical and biophysical studies are limited. We have developed a second generation Escherichia coli polycistronic expression system which improves on the modularity of our original pST39 polycistronic system. This pST44 expression system simplifies the construction of polycis-tronic plasmids, particularly of variant plasmids expressing deletion or point mutations in any subunit. To facilitate purification of the expressed complex, we have prepared a suite of 72 plasmids which allows individual subunits to be tagged at the N- or C-terminus with six permanent or cleavable peptide affinity tags...
April 2005: Protein Expression and Purification
https://www.readbyqxmd.com/read/14857780/stereoisomerization-of-the-polycis-compounds-pro-gamma-carotene-and-prolycopene-in-chickens-and-hens
#4
H J DEUEL, J GANGULY, B K KOE, L ZECHMEISTER
No abstract text is available yet for this article.
August 1951: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/13445225/stepwise-stereoisomerization-of-prolycopene-a-polycis-carotenoid-to-all-trans-lycopene
#5
E F MAGOON, L ZECHMEISTER
No abstract text is available yet for this article.
July 1957: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/1449703/dolichol-a-curriculum-cognitionis
#6
REVIEW
F W Hemming
Dolichols were first described about 30 years ago when animal tissues were being examined for the presence of a putative precursor to the polyisoprenoid side chain of ubiquinone. These long-chain 2,3-dihydro-polycis-isoprenoid alcohols are found in all eukaryotic organisms. In many plant tissues they are accompanied by families of other polyisoprenoid alcohols that are usually similar molecules and possess an unsaturated alpha-isoprene residue. Analogy with the role of bactoprenyl phosphates in the synthesis of bacterial wall glycans led to the discovery that the mono- and di-phosphates of dolichols function as cofactors in protein N-glycosylation, involving the formation of glycosylated derivatives of dolichol as intermediates...
June 1992: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
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