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https://www.readbyqxmd.com/read/29238111/distal-radius-nonunion-after-volar-locking-plate-fixation-of-a-distal-radius-fracture-a-case-report
#1
Takaaki Shinohara, Hitoshi Hirata
We describe a 59-year-old man who had nonunion of a right distal radius fracture after volar locking plate fixation. He underwent open reduction and internal fixation with a volar locking plate system for a dorsally displaced, unstable distal radius fracture at a previous hospital 5 months ago. Radiographs of the injured wrist showed nonunion of the distal radius with 1.5-mm ulnar minus variance. Radiographs of the unaffected wrist showed 3.5-mm ulnar plus variance. Intraoperative findings of surgical revision showed an unstable nonunion; thus, debridement of the nonunion, autogenous inlay bone grafting, and internal fixation using another type of volar locking plate system were performed...
November 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29238018/-regulation-of-bone-by-il-17-producing-t-cells
#2
Kazuo Okamoto
  Bone is a component of the skeletal-locomotor system but also functions as an immunological organ that harbors hematopoietic stem and progenitor cells. Since the immune and skeletal systems are closely related through a number of shared regulatory molecules including cytokines and receptors, bone can be affected in various immune disorders. Rheumatoid arthritis is a typical disease in which the immune system affects the bone metabolism. The enhanced activity of osteoclasts by the activation of Th17 cells causes the joint destruction in rheumatoid arthritis...
2017: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29237448/surgical-outcome-of-atypical-subtrochanteric-and-femoral-fracture-related-to-bisphosphonates-use-in-osteoporotic-patients-with-or-without-teriparatide-treatment
#3
Wen-Ling Yeh, Chun-Yi Su, Chia-Wei Chang, Chien-Hao Chen, Tsai-Sheng Fu, Lih-Huei Chen, Tung-Yi Lin
BACKGROUND: Atypical subtrochanteric fracture and femoral fracture have been considered to be rare complications related to long-term bisphosphonates use. A reduced bone turnover rate may lead to delayed bone healing. Limited data have revealed that teriparatide treatment may reverse the effect of bisphosphonates and be effective in bone healing. METHODS: We reviewed patients with atypical subtrochanteric and femoral fracture related to bisphosphonates use between January 2008 and December 2014...
December 13, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29236797/nandrolone-decanoate-appears-to-increase-bone-callus-formation-in-young-adult-rats-after-a-complete-femoral-fracture
#4
Ana Paula Franttini Garcia Moreno Guimarães, Mariana Maloste Butezloff, Ariane Zamarioli, João Paulo Mardegan Issa, José Batista Volpon
PURPOSE: To evaluate the influence of nandrolone decanoate on fracture healing and bone quality in normal rats. METHODS: Male rats were assigned to four groups (n=28/group): Control group consisting of animals without any intervention, Nandrolone decanoate (DN) group consisting of animals that received intramuscular injection of nandrolone decanoate, Fracture group consisting of animals with a fracture at the mid-diaphysis of the femur, and Fracture and nandrolone decanoate group consisting of animals with a femur fracture and treatment with nandrolone decanoate...
November 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29234646/a-retrospective-analysis-of-surgically-treated-complex-proximal-femur-fractures-with-proximal-femoral-locking-compression-plate
#5
Syed Ibrahim, Jimmy Joseph Meleppuram
Objective: Analyze the outcomes of proximal femoral locking compression plate (PF-LCP) in these complex fractures. Methods: This study retrospectively analyzed 21 proximal femoral fractures treated with PF-LCP from June 2013 to February 2015. There were 15 females (71%) and six males (29%) with an average age of 61.4 years (range: 34-80 years). The peritrochanteric fractures constituted by intertrochanteric and subtrochanteric fractures were classified by the Boyd and Griffin classification and Seinshemier's classification, respectively...
November 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/29232698/low-energy-extracorporeal-shockwave-therapy-eswt-improves-metaphyseal-fracture-healing-in-an-osteoporotic-rat-model
#6
Gina A Mackert, Matthias Schulte, Christoph Hirche, Dimitra Kotsougiani, Julian Vogelpohl, Bernd Hoener, Teresa Fiebig, Stefanie Kirschner, Marc A Brockmann, Marcus Lehnhardt, Ulrich Kneser, Leila Harhaus
PURPOSE: As result of the current demographic changes, osteoporosis and osteoporotic fractures are becoming an increasing social and economic burden. In this experimental study, extracorporeal shock wave therapy (ESWT), was evaluated as a treatment option for the improvement of osteoporotic fracture healing. METHODS: A well-established fracture model in the metaphyseal tibia in the osteoporotic rat was used. 132 animals were divided into 11 groups, with 12 animals each, consisting of one sham-operated group and 10 ovariectomized (osteoporotic) groups, of which 9 received ESWT treatment...
2017: PloS One
https://www.readbyqxmd.com/read/29232643/mechanical-corrosion-and-biocompatibility-behaviour-of-mg-3zn-ha-biodegradable-composites-for-orthopaedic-fixture-accessories
#7
Satish Jaiswal, R Manoj Kumar, Pallavi Gupta, Murali Kumaraswamy, Partha Roy, Debrupa Lahiri
Development of biodegradable implants has grown into one of the important areas in medical science. Degradability becomes more important for orthopaedic accessories used to support fractured and damaged bones, in order to avoid second surgery for their removal after healing. Clinically available biodegradable orthopaedic materials are mainly made of polymers or ceramics. These orthopaedic accessories have an unsatisfactory mechanical strength, when used in load-bearing parts. Magnesium and its alloys can be suitable candidate for this purpose, due to their outstanding strength to weight ratio, biodegradability, non-toxicity and mechanical properties, similar to natural bone...
November 21, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29230303/case-series-of-paragonimiasis-from-nepal
#8
Ranjit Sah, Shusila Khadka
Paragonimiasis is an important food-borne parasitic zoonosis caused by trematodes of genus Paragonimus. We report case series of paragonimiasis with common symptoms of cough with blood tinged sputum, shortness of breath, chest pain with occasional fever, eosinophilia and radiological findings mimicking pulmonary tuberculosis and had taken anti-tubercular drug despite all investigation negative for tuberculosis without improvement. They all had common history of consumption of raw/undercooked crab. There is a local belief in remote villages of Nepal that eating raw crab helps in healing bone fracture and cure jaundice...
November 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/29230039/gli1-identifies-osteogenic-progenitors-for-bone-formation-and-fracture-repair
#9
Yu Shi, Guangxu He, Wen-Chih Lee, Jennifer A McKenzie, Matthew J Silva, Fanxin Long
Bone formation in mammals requires continuous production of osteoblasts throughout life. A common molecular marker for all osteogenic mesenchymal progenitors has not been identified. Here, by lineage-tracing experiments in fetal or postnatal mice, we discover that Gli1+ cells progressively produce osteoblasts in all skeletal sites. Most notably, in postnatal growing mice, the Gli1+ cells residing immediately beneath the growth plate, termed here "metaphyseal mesenchymal progenitors" (MMPs), are essential for cancellous bone formation...
December 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/29229668/multiple-myeloma-and-bone-the-fatal-interaction
#10
Silvia Marino, G David Roodman
Multiple myeloma (MM) is the second-most-common hematologic malignancy and the most frequent cancer to involve bone. MM bone disease (MMBD) has devastating consequences for patients, including dramatic bone loss, severe bone pain, and pathological fractures that markedly decrease the quality of life and impact survival of MM patients. MMBD results from excessive osteoclastic bone resorption and persistent suppressed osteoblastic bone formation, causing lytic lesions that do not heal, even when patients are in complete and prolonged remission...
December 11, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/29229541/results-of-percutaneous-fixation-and-distal-radius-core-decompression-in-scaphoid-waist-non-unions-treated-without-grafting
#11
S S Dedeoğlu, Y İmren, H Çabuk, A C Tekin, Y C Türe, H Gürbüz
Scaphoid non-union management is still a challenge in clinical practice for orthopaedic surgeons. Though several treatment methods have been described, there is an ongoing debate about optimum management. Based on new concepts about avascular conditions, promising results were reported with metaphyseal decompression of the distal radius by increasing the vascularization of the radial column of the carpus. We aimed to evaluate the clinical, radiological, and functional outcomes of distal radius core decompression and fixation with palmar percutaneous cannulated compression screws without grafting in patients with scaphoid waist fracture non-union...
December 8, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/29228800/fifth-metatarsal-jones-fractures-in-the-athlete
#12
David A Porter
Fifth metatarsal fractures, otherwise known as "Jones" fractures, occur commonly in athletes and nonathletes alike. While recent occurrence in the popular elite athlete has increased public knowledge and interest in the fracture, this injury is common at all levels of sport. This review will focus on all three types of Jones fractures. The current standard for treatment is operative intervention with intramedullary screw fixation. Athletes typically report an acute episode of lateral foot pain, described as an ache...
December 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/29228043/novel-systems-for-the-application-of-isolated-tensile-compressive-and-shearing-stimulation-of-distraction-callus-tissue
#13
Nicholaus Meyers, Julian Schülke, Anita Ignatius, Lutz Claes
BACKGROUND: Distraction osteogenesis is a procedure widely used for the correction of large bone defects. However, a high complication rate persists, likely due to insufficient stability during maturation. Numerical fracture healing models predict bone regeneration under different mechanical conditions allowing fixation stiffness optimization. However, most models apply a linear elastic material law inappropriate for the transient stresses/strains present during limb lengthening or segment transport...
2017: PloS One
https://www.readbyqxmd.com/read/29227827/determining-when-a-fracture-occurred-does-the-method-matter-analysis-of-the-similarity-of-three-different-methods-for-estimating-time-since-fracture-of-juvenile-long-bones
#14
Anne Drury, Craig Cunningham
Radiographic fracture date estimation is a critical component of skeletal trauma analysis in the living. Several timetables have been proposed for how the appearance of radiographic features can be interpreted to provide a likely time frame for fracture occurrence. This study compares three such timetables for pediatric fractures, by Islam et al. (2000), Malone et al. (2011), and Prosser et al. (2012), in order to determine whether the fracture date ranges produced by using these methods are in agreement with one another...
November 26, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29226199/effectiveness-of-minimally-invasive-plate-osteosynthesis-mipo-on-comminuted-tibial-or-femoral-fractures
#15
Ali Andalib, Erfan Sheikhbahaei, Zeynab Andalib, Mohammad A Tahririan
Background: Comminuted fractures happen frequently due to traumas. Fixation without opening the fracture site, known as minimally invasive plate osteosynthesis (MIPO), has recently become prevalent. This study has been designed to assess the outcomes of this treatment for tibial and femoral comminuted fractures. Methods: A total of 60 patients with comminuted femoral or tibial fractures were operated with MIPO method in this cross-sectional study at Alzahra university hospital in 2015...
September 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29225463/nano-copper-bearing-stainless-steel-promotes-fracture-healing-by-accelerating-the-callus-evolution-process
#16
Lei Wang, Guoyuan Li, Ling Ren, Xiangdong Kong, Yugang Wang, Xiuguo Han, Wenbo Jiang, Kerong Dai, Ke Yang, Yongqiang Hao
Treatment for fractures requires internal fixation devices, which are mainly produced from stainless steel or titanium alloy without biological functions. Therefore, we developed a novel nano-copper-bearing stainless steel with nano-sized copper-precipitation (317L-Cu SS). Based on previous studies, this work explores the effect of 317L-Cu SS on fracture healing; that is, proliferation, osteogenic differentiation, osteogenesis-related gene expression, and lysyl oxidase activity of human bone mesenchymal stem cells were detected in vitro...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29223594/femoral-neck-fractures-after-removal-of-hardware-in-healed-trochanteric-fractures
#17
REVIEW
Antonio Barquet, Peter V Giannoudis, Andrés Gelink
INTRODUCTION: Hardware removal in healed trochanteric fractures (TF) in the absence of infection or significant mechanical complications is rarely indicated. However, in patients with persistent pain, prominent material and discomfort in the activities of daily living, the implant is eventually removed. Publications of ipsilateral femoral neck fracture after removal of implants from healed trochanteric fractures (FNFARIHTF) just because of pain or discomfort are rare. The purpose of this systematic review of the literature is to report on the eventual risk factors, the mechanisms, the clinical presentation, and frequency, and to pay special emphasis in their prevention...
December 2017: Injury
https://www.readbyqxmd.com/read/29217668/induced-global-deletion-of-glucocorticoid-receptor-impairs-fracture-healing
#18
Anna E Rapp, Yasmine Hachemi, Julia Kemmler, Mascha Koenen, Jan Tuckermann, Anita Ignatius
Although endogenous glucocorticoids (GCs) are important regulators of bone integrity and the immune system, their role in bone repair after fracture-a process highly dependent on inflammation and bone formation-is unclear. Because most effects of GCs are mediated by the glucocorticoid receptor (GR), we used an inducible global GR knockout (GRgtROSACreERT2) mouse model to eliminate endogenous GC action in all cells contributing to bone repair. The healing process was analyzed by cytokine/chemokine multiplex analysis, flow cytometry, histology, gene-expression analysis, microcomputed tomography, and biomechanical analysis...
December 7, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29216793/parametric-study-of-patient-specific-femoral-locking-plates-based-on-a-combined-musculoskeletal-multibody-dynamics-and-finite-element-modeling
#19
Xunjian Fan, Zhenxian Chen, Zhongmin Jin, Qida Zhang, Xuan Zhang, Yinghu Peng
A combined musculoskeletal multibody dynamics and finite element modeling was performed to investigate the effects of design parameters on the fracture-healing efficiency and the mechanical property of a patient-specific anatomically adjusted femoral locking plate. Specifically, the screw type, the thickness and material of the locking plate, the gap between two femoral fragments (fracture gap) and the distance between bone and plate (interface gap) were evaluated during a human walking. We found that the patient-specific locking plate possessed greater mechanical strength and more efficient fracture healing than the corresponding traditional plate...
December 1, 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29216693/a-comparative-study-in-patients-with-fractures-of-the-lower-limbs-between-rivaroxaban-versus-enoxaparin-and-its-impact-on-bone-healing-time
#20
P Peláez-Damy, A Torres-Gómez, F Mas-Celis, M Martínez-Villalobos
BACKGROUND: Each year it is estimated in the United States an approximate of 8 million fractures; 5 to 10% develop delayed union or absence of periosteal new bone. There are several factors that can cause delay in fracture healing, among the well known, is the use of prophylactic antithrombotic therapy for deep vein thrombosis (DVT). DVT appears in 40 to 60% of the patients undergoing orthopedic surgery without prophylactic antithrombotic therapy. The goal of this study was to assess whether there is a difference in time of bone healing in lower limb fractures (femur and tibia) comparing rivaroxaban to enoxaparin as the prophylactic antithrombotic management...
July 2017: Acta Ortopédica Mexicana
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