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https://www.readbyqxmd.com/read/29032818/radiographic-histologic-and-biomechanical-evaluation-of-combined-application-of%C3%A2-platelet-rich-fibrin-with-blood-clot-in%C3%A2-regenerative-endodontics
#1
Ronghui Zhou, Yumin Wang, Yuemin Chen, Shuai Chen, Hongbing Lyu, Zhiyu Cai, Xiaojing Huang
INTRODUCTION: No in vivo study has been reported on the mechanical reinforcement of a tooth after regenerative endodontic treatment (RET). The present work aimed to evaluate the concurrent use of platelet-rich fibrin (PRF) with a blood clot (BC) in RET concerning periapical healing, root development, and tooth structural reinforcement. METHODS: In our study, 24 premolars from 3 beagle dogs were assigned into control, BC, and PRF + BC groups. Periapical healing was monitored with quantitative measurements of root elongation and thickening radiographically...
October 9, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29032173/the-reduced-osteogenic-potential-of-nf1-deficient-osteoprogenitors-is-egfr-independent
#2
S E Tahaei, G Couasnay, Y Ma, N Paria, J Gu, B F Lemoine, X Wang, J J Rios, F Elefteriou
Neurofibromatosis type 1 (NF1) is a common genetic disorder caused by mutations in the NF1 gene. Recalcitrant bone healing following fracture (i.e. pseudarthrosis) is one of the most problematic skeletal complications associated with NF1. The etiology of this condition is still unclear; thus, pharmacological options for clinical management are limited. Multiple studies have shown the reduced osteogenic potential of Nf1-deficient osteoprogenitors. A recent transcriptome profiling investigation revealed that EREG and EGFR, encoding epiregulin and its receptor Epidermal Growth Factor Receptor 1, respectively, were among the top over-expressed genes in cells of the NF1 pseudarthrosis site...
October 11, 2017: Bone
https://www.readbyqxmd.com/read/29031822/a-systematic-review-of-volar-locking-plate-removal-after-distal-radius-fracture
#3
REVIEW
Michiro Yamamoto, Yuki Fujihara, Nasa Fujihara, Hitoshi Hirata
BACKGROUND: Indication of volar locking plate (VLP) removal after bony healing of distal radius fracture (DRF) is controversial. Studies with various range of removal rate were reported. The purpose of this systematic review was to investigate the frequency and the reasons of hardware removal over the world. We hypothesized that more frequent VLP removal contribute to better clinical outcomes. METHODS: The authors searched all available literature in the PubMed and EMBASE databases for articles reporting on outcomes of treatment using VLP for DRF...
October 9, 2017: Injury
https://www.readbyqxmd.com/read/29031012/the-role-of-diabetes-mellitus-and-bmi-in-the-surgical-treatment-of-ankle-fractures
#4
Riccardo Maria Lanzetti, Domenico Lupariello, Teresa Venditto, Matteo Guzzini, Antonio Ponzo, Angelo De Carli, Andrea Ferretti
BACKGROUND: Open reduction and internal fixation is the standard treatment for displaced ankle fractures. However, the presence of comorbidities such as diabetes mellitus and BMI is associated with poor bone quality, and these factors may predict the development of postoperative complications. The study aim was to assess the role of diabetes mellitus and BMI in wound healing in patients younger than 65 years who were surgically treated for malleoli fractures. METHODS: Ninety patients, aged from 18 to 65 years old, with surgically treated ankle fracture, were retrospectively enrolled...
October 14, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29027187/midterm-results-of-trochanteric-flip-osteotomy-technique-for-management-of-fractures-around-the-hip
#5
Vivek Trikha, Saubhik Das, Arkesh Madegowda, Prabhat Agrawal
INTRODUCTION: In this study, we aimed to investigate safety and efficacy of the trochanteric flip osteotomy with surgical hip dislocation technique in selected displaced acetabular and femoral head fractures with clinico-radiological outcome and potential complications. MATERIALS AND METHODS: We retrospectively reviewed 32 patients from January 2009 to June 2014. Selected displaced acetabular fractures with comminution and/or cranial extension of posterior wall, marginal impaction, intraarticular fragment, femoral head fractures and hip fracture-dislocations were operated by this modified approach of trochanteric flip osteotomy and surgical hip dislocation...
October 9, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29027119/mollugin-enhances-the-osteogenic-action-of-bmp-2-via-the-p38-smad-signaling-pathway
#6
Seong-Hee Moon, Ikyon Kim, Seong Hwan Kim
Bone morphogenetic protein 2 (BMP-2) has been used clinically to encourage bone regeneration; although, there can be major side effects with larger doses. Therefore, there is a need to identify new small molecules to potentiate the osteogenic action of BMP-2. In this study, we investigated the effect of mollugin on bone formation in murine bi-potential mesenchymal progenitor C2C12 cells by combination with BMP-2. We found mollugin could enhance the BMP-2-mediated osteoblast differentiation of C2C12 cells. This was accompanied by the induction of other osteogenic BMPs...
October 12, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29026917/-fractures-of-the-lower-extremities-in-childhood-part-2-lower-leg-and-ankle-fractures
#7
M Voth, L Kremer, I Marzi
The treatment of pediatric patients in trauma surgery is a special situation in every aspect. For deciding on the correct treatment of fractures of the lower leg and ankle joint, various parameters, such as residual growth rate, skeletal age and height of the patient are decisive. The differences between fractures in children and adolescents are the open epiphyseal plate and the resulting residual growth. The bones of young children have a higher healing tendency and a greater potential for correction than in adolescents...
October 12, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29026819/the-role-of-dynamic-ultrasound-in-the-immediate-conservative-treatment-of-volar-plate-injuries-of-the-pip-joint-a-series-of-78-patients
#8
Franck Marie Leclère, Lukas Mathys, Bettina Juon, Esther Vögelin
INTRODUCTION: The management of volar plate avulsion fractures in the context of a stable joint and a bony fragment of less than 30% has traditionally been conservative. This study was performed to assess volar plate healing with high-resolution ultrasound in order to provide early full mobilization. MATERIAL AND METHODS: Between January 2012 and December 2013, 78 patients with volar plate injuries of the proximal interphalangeal (PIP) joints (42 distortions and 36 dislocations) were treated conservatively in our department for volar plate avulsion fracture associated with stable joint and bony fragment inferior to 30% of the intra-articular surface assessed both by radiography and ultrasound...
August 2017: Plastic Surgery
https://www.readbyqxmd.com/read/29026642/locking-system-strengthened-by-biomimetic-mineralized-collagen-putty-for-the-treatment-of-osteoporotic-proximal-humeral-fractures
#9
Cheng Peng, Hai-Peng Wang, Jia-Hua Yan, Tian-Xi Song
The current study is to observe the effect of the locking system strengthened by biomimetic mineralized collagen putty for the treatment of senile proximal humeral osteoporotic fractures. From January 2012 to December 2015, 80 cases of senile patients with osteoporotic proximal humeral fractures were randomly divided into an observation group and a control group, each group with a total of 40 cases. The control group was simply treated with locking plate. The observation group was treated with locking plate in combination with biomimetic mineralized collagen putty...
October 2017: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29025612/clavicle-aseptic-nonunion-is-there-a-place-for-cortical-allogenic-strut-graft
#10
Giuseppe Rollo, Giovanni Vicenti, Roberto Rotini, Antonella Abate, Antonio Colella, Antonio D'Arienzo, Massimiliano Carrozzo, Biagio Moretti
We investigated functional and radiological outcome in 57 cases of midshaft clavicle nonunion treated with open reduction and internal fixation with plate and screws over a 13 year-period. Intercalary bone graft was used in 42 patients; opposite autologous strut graft was used in 31 cases to provide mechanical support to the host bone. Patients were analysed using chart and radiological review and assessed with DASH questionnaire obtained at the latest follow-up. 37 patients were male while 20 were females, with a mean age of 35 years (63-17)...
October 2017: Injury
https://www.readbyqxmd.com/read/29025605/comparison-between-carbon-peek-volar-locking-plates-and-titanium-volar-locking-plates-in-the-treatment-of-distal-radius-fractures
#11
Dario Perugia, Matteo Guzzini, Daniele Mazza, Carlo Iorio, Carolina Civitenga, Andrea Ferretti
INTRODUCTION: Unstable intra articular fractures of distal radius are frequently being managed with open reduction and internal fixation. Volar locking plate based on polyetheretherketon (PEEK) polymer has developed lately as an alternative to conventional metallic devices. The advantage of this kind of plates include the lack of metal allergies, radiolucency, low artefacts on MRI or imaging scans and the high resistance associated to loading forces. The aim of this study was to evaluate the clinical and radiological results using a new Carbon-PEEK volar locking plate compared with titanium volar locking plates for the treatment of distal radius fractures...
October 2017: Injury
https://www.readbyqxmd.com/read/29024060/loss-of-dnmt3b-in-chondrocytes-leads-to-delayed-endochondral-ossification-and-fracture-repair
#12
Cuicui Wang, Yousef Abu-Amer, Regis J O'Keefe, Jie Shen
Despite advanced understanding of signaling mediated by local and systemic factors, the role of epigenetic factors in the regulation of bone regeneration remains vague. The DNA methyltransferases (Dnmts) Dnmt3a and Dnmt3b have tissue specific expression patterns and create unique methylation signatures to regulate gene expression. Using a stabilized murine tibia fracture model we find that Dnmt3b is induced early in fracture healing, peaks at 10 days post fracture (dpf), and declines to nearly undetectable levels by 28 dpf...
October 10, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29023221/evaluation-of-the-effect-of-phototherapy-in-patients-with-mandibular-fracture-on-mandibular-dynamics-pain-edema-and-bite-force-a-pilot-study
#13
Leandro Lauriti, João Gualberto de Cerqueira Luz, Raquel Agnelli Mesquita-Ferrari, Kristianne Porta Santos Fernandes, Alessandro Melo Deana, Anna Carolina Ratto Tempestini Horliana, Larissa Costa-Santos, Aldo Brugnera Junior, Sandra Kalil Bussadori
OBJECTIVE: The aim of this study was to evaluate the effect of phototherapy on bite force, facial swelling, mandibular movements, and pain in patients having undergone surgical treatment for mandibular fractures. BACKGROUND: These are among the predominant types of facial fractures, and treatment involving surgical fixation with titanium plates is one of the most common procedures in oral-maxillofacial surgery. Phototherapy has been used to accelerate the muscle healing process and significantly improves muscle regeneration by inducing the formation of new muscle fibers...
October 12, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29022165/a-new-approach-to-treat-bone-gaps-after-midfacial-and-zygomatic-fractures-with-a-collagen-membrane
#14
Matthias Krause, Heike Hümpfner-Hierl, Lutz Völker, Thomas Hierl, Niels Christian Pausch
PURPOSE: The aim of the study was to analyze the eligibility of resorbable collagen membrane in the treatment of midfacial fractures to prevent gap formation and subsequent cheek tissue retraction. MATERIAL AND METHODS: We included nine patients (six males, three females; mean age 51; range 20-73 years; mean bone gap size 8.03 × 13.12 mm) in a retrospective study design. The defect size was assessed by ultrasound. RESULTS: After a healing period of 4 to 55 weeks, treatment resulted in a significant reduction of gap size (residual mean bone gap size 6...
October 11, 2017: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29021995/tumor-induced-osteomalacia
#15
Pablo Florenzano, Rachel I Gafni, Michael T Collins
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome clinically characterized by bone pain, fractures and muscle weakness. It is caused by tumoral overproduction of fibroblast growth factor 23 (FGF23) that acts primarily at the proximal renal tubule, decreasing phosphate reabsorption and 1α-hydroxylation of 25 hydroxyvitamin D, thus producing hypophosphatemia and osteomalacia. Lesions are typically small, benign mesenchymal tumors that may be found in bone or soft tissue, anywhere in the body...
December 2017: Bone Reports
https://www.readbyqxmd.com/read/29021874/functional-outcome-of-isolated-hoffa-fractures-treated-with-cannulated-cancellous-screw
#16
R Singh, R B Singh, M Mahendra
Introduction: Isolated Hoffa fracture is an infrequent injury and little research has been done on this subject. The purpose of this study was to evaluate the functional outcome and complications of surgically managed Hoffa fractures with cannulated cancellous screw. Materials and Methods: Between 2011 and 2014, eight isolated Hoffa fractures in seven adult patients with mean age 39.8±11.9 years (range 25-60 years) were managed with cannulated cancellous screw of 6.5mm diameter applied in anterior to posterior direction using swashbuckler and medial parapatellar approach for lateral and medial Hoffa fractures respectively...
July 2017: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/29020880/pulsed-electromagnetic-fields-and-tissue-engineering-of-the-joints
#17
Kenjiro Iwasa, Reddi A Hari
BACKGROUND: Bone and cartilage joint formation, maintenance and regeneration are regulated by both chemical and physical signals. Among the physical signals there is increasing realization of the role of Pulsed electromagnetic fields (PEMF) in the treatment of nonunions of bone fractures. The discovery of the piezoelectric properties of bone by Fukada and Yasuda in 1953 in Japan established the foundation of this field. Pioneering research by Bassett and Brighton and their teams resulted in the approval by Food and Drug Administration (FDA) the use of PEMF in treatment of fracture healing...
October 12, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29019890/external-fixation-combined-with-delayed-internal-fixation-in-treatment-of-tibial-plateau-fractures-with-dislocation
#18
Xingguang Tao, Nong Chen, Fugen Pan, Biao Cheng
The aim of this study was to evaluate the clinical efficacy of external fixation, delayed open reduction, and internal fixation in treating tibial plateau fracture with dislocation.Clinical data of 34 patients diagnosed with tibial plateau fracture complicated with dislocation between January 2009 and May 2015 were retrospectively analyzed. Fifteen patients in group A underwent early calcaneus traction combined with open reduction and internal fixation and 19 in group B received early external fixation combined with delayed open reduction and internal fixation...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29019882/koebner-phenomenon-induced-by-failed-revisional-orthopedic-surgery-but-remitted-with-bone-union-a-case-report
#19
Yiing-Feng Hwang, Nai-Yuan Wu, Pei-Yuan Lee
RATIONALE: Trauma or surgical incision might cause Koebner phenomenon (KP) in patients with cutaneous diseases, but seldom studies reported KP induced by repeated orthopedic surgery. PATIENT CONCERNS: The 22-year-old man did not have any prior histories of cutaneous diseases. Two months after the revision surgery for nonunion of the left femoral shaft fracture, KP was noted by psoriasis presented at the surgical scar, left thigh, scalp, and trunk. Phototherapy and topical treatments were prescribed but the effect was limited...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29019535/what-is-the-ideal-working-length-for-bridge-plating-osteosynthesis-of-a-femoral-shaft-fracture-a-multinational-online-survey-evaluation
#20
Vincenzo Giordano, Roger Pletsch Paes, Gustavo Barbosa de-Queiroz, José Claudio Lira, William Dias Belangero, Robinson Esteves Santos Pires, Pedro José Labronici
OBJECTIVE: to evaluate how orthopedic surgeons in Latin America define the working length for distinct patterns of femoral shaft fracture. METHODS: a survey was developed presenting different options of working length in four femoral fracture patterns. The survey was submitted to the participants using Google Forms tool. The association between professional characteristics and medical management options according to each type of fracture was analyzed by Chi-square test, with 5% significance level...
July 2017: Revista do Colégio Brasileiro de Cirurgiões
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