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Fracture + healing

J-B Ge, J-T Lin, H-Y Hong, Y-J Sun, Y Li, C-M Zhang
OBJECTIVE: To investigate whether miR-374b can promote the differentiation of MSCs into osteoblasts by mediating PTEN, thus promoting fracture healing. MATERIALS AND METHODS: Primary cultured mouse mesenchymal stem cells were obtained for following experiments. Flow cytometry was used to determine the expression of MSCs surface antigens to identify the purity. Alizarin red staining was used to detect whether MSCs could differentiate into osteoblasts. QRT-PCR was used to detect the expression of osteogenic marker genes as well as miR-374b and PTEN in bone marrow-derived MSCs from fractured mice model...
June 2018: European Review for Medical and Pharmacological Sciences
Michael Nienhaus, Ivan Zderic, Dieter Wahl, Boyko Gueorguiev, Pol Maria Rommens
BACKGROUND: Displaced transverse patellar fractures require open reduction and internal fixation. State-of-the-art stabilization techniques are tension band wiring (TBW) using Kirschner wires or cannulated screws. These techniques are associated with high rates of secondary fracture displacement, implant migration, implant prominence, wound-healing disturbances, and the need for implant removal. Recently, a locked intraosseous patellar nail prototype was developed. The aim of the present study was to investigate the biomechanical performance of this nail compared with TBW using cannulated screws...
June 20, 2018: Journal of Bone and Joint Surgery. American Volume
Xueliang Cui, Hui Chen, Yunfeng Rui, Yang Niu, He Li
Objectives Two-stage open reduction and internal fixation (ORIF) and limited internal fixation combined with external fixation (LIFEF) are two widely used methods to treat Pilon injury. However, which method is superior to the other remains controversial. This meta-analysis was performed to quantitatively compare two-stage ORIF and LIFEF and clarify which method is better with respect to postoperative complications in the treatment of tibial Pilon fractures. Methods We conducted a meta-analysis to quantitatively compare the postoperative complications between two-stage ORIF and LIFEF...
January 1, 2018: Journal of International Medical Research
Min-Cheol Kim, Sang-Don Joo, Sung-Taek Jung
PURPOSE: To evaluate the role of fractures on pathologic bone in healing of proximal humerus unicameral bone cysts (UBCs) and investigate the clinical factors that affect healing of UBCs after fractures on pathologic bone. METHODS: This prospective study was carried out between 2002 and 2014. We evaluated 56 patients with a UBC accompanying fractures on pathologic bone in the proximal humerus. Clinical data were collected from the patients' medical records. Age, gender, degree of fracture displacement, location of cyst, and cyst size were investigated, and we assessed how these factors affected cyst healing...
May 2018: Journal of Orthopaedic Surgery
Alain Borgeat, Christian Ofner, Andrea Saporito, Mazda Farshad, José Aguirre
STUDY OBJECTIVE: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used in postoperative pain management. While an increasing number of in vitro and animal studies point toward an inhibitory effect of NSAIDs on bone healing process, the few existing retro- and prospective clinical studies present conflicting data. DESIGN: The aim of this qualitative, systematic review was to investigate the impact of perioperative use of NSAIDs in humans on postoperative fracture/spinal fusion healing compared to other used analgesics measured as fracture nonunion with radiological control...
June 15, 2018: Journal of Clinical Anesthesia
Felipe Fernandes Gonçalves, Leonardo Dau, Cristiano Antonio Grassi, Fabiano Rogério Palauro, Ayrton Andrade Martins Neto, Patrícia Caroline Gapski Pereira
Objective: The objective of this study is to analyze the surgical results of humeral shaft fracture treatment and describe its epidemiology. Methods: Retrospective study that identified all patients treated with surgical fixation of humeral shaft fractures between December of 2014 and June of 2016 in a trauma reference center. All medical records were reviewed in search of epidemiological data referent to the trauma and post-operative results, including radiographic healing of the fracture and related complications...
March 2018: Revista Brasileira de Ortopedia
Maria Eischen-Loges, Karla M C Oliveira, Mit B Bhavsar, John H Barker, Liudmila Leppik
Background: Electrical stimulation (ES) has a long history of successful use in the clinical treatment of refractory, non-healing bone fractures and has recently been proposed as an adjunct to bone tissue-engineering treatments to optimize their therapeutic potential. This idea emerged from ES's demonstrated positive effects on stem cell migration, proliferation, differentiation and adherence to scaffolds, all cell behaviors recognized to be advantageous in Bone Tissue Engineering (BTE)...
2018: PeerJ
Do-Won Lee, Jae-Young Kwon, Hae-Kyu Kim, Hyeon-Jeong Lee, Eun-Soo Kim, Hyae-Jin Kim, Hyung-Joon Kim, Han-Bit Lee
Bone remodeling plays an important role in the bone healing process; for example, following fracture. The relative ratio of the receptor activator of nuclear factor kappa B ligand (RANKL)/ osteoprotegerin (OPG) controls osteoclast differentiation, thereby playing a pivotal role in the regulation of bone remodeling. Propofol, a widely used anesthetic agent in orthopedic procedures, is considered to possess potential antioxidant properties owing to its structural similarity to α-tocopherol. Antioxidants are known to enhance bone healing...
2018: International Journal of Medical Sciences
Galina Shapiro, Raphael Lieber, Dan Gazit, Gadi Pelled
PURPOSE OF REVIEW: The purpose of this review is to discuss the recent advances in gene therapy as a treatment for bone regeneration. While most fractures heal spontaneously, patients who present with fracture nonunion suffer from prolonged pain, disability, and often require additional operations to regain musculoskeletal function. RECENT FINDINGS: In the last few years, BMP gene delivery by means of electroporation and sonoporation resulted in repair of nonunion bone defects in mice, rats, and minipigs...
June 16, 2018: Current Osteoporosis Reports
Shaoyu Wu, Qiang Yu, Anli Lai, Jing Tian
Pulsed electromagnetic fields (PEMFs) are effective in healing fractures and improving osteoporosis. However, their effect on mesenchymal cells remains largely unknown. In this study, the effects of PEMF on osteoblastogenesis and its underlying molecular signaling mechanisms were systematically investigated in C3H10T1/2 cells. C3H10T1/2 mesenchymal cells were exposed to 30-Hz PEMF bursts at various intensities for 3 consecutive days. The optimal PEMF exposure (30 Hz, 1 mT, 2 h/day) was applied in subsequent experiments...
June 14, 2018: Biochemical and Biophysical Research Communications
Hua-Lun Wang, Pei-Pei Zhang, Li Meng, Su-Xia Liang, Hao Liu, Ying-Bin Yan
PURPOSE: The aim of this experimental study was to investigate the role of the fibrous layer of the condylar head in the formation of temporomandibular joint (TMJ) ankylosis in a sheep model of intracapsular condylar fracture. MATERIALS AND METHODS: Six growing Xiao-wei Han sheep were used in the study, and bilateral TMJ surgery was performed in each sheep. In the left TMJ, sagittal fracture of the condyle, removal of the fibrous layer of the condylar head, excision of two thirds of the disc, and removal of the fibrous zone of the glenoid fossa were performed...
May 24, 2018: Journal of Oral and Maxillofacial Surgery
Xin Yu, Qilong Wan, Gu Cheng, Xin Cheng, Jing Zhang, Janak L Pathak, Zubing Li
Mesenchymal stem cells homing and migration is a crucial step during bone fracture healing. Hypoxic environment in fracture site induces bone marrow mesenchymal stem cells (BMSCs) migration, but its mechanism remains unclear. Our previous study and studies by other groups have reported the involvement of signal transducer and activator of transcription 3 (STAT3) pathway in cell migration. However, the role of STAT3 pathway in hypoxia-induced cell migration is still unknown. In this study, we investigated the role of STAT3 signaling in hypoxia-induced BMSCs migration and osteogenic differentiation...
June 16, 2018: Cell Biology International
Giuseppe Rollo, Roberto Rotini, Denise Eygendaal, Paolo Pichierri, Michele Bisaccia, Ante Prkic, Alessandro Stasi, Luigi Meccariello
BACKGROUND: Anatomic surgical reduction of intra-articular fractures of the distal humerus is important to achieve the best long-term outcomes and prevent post-traumatic arthritis. In this study we compared the radiographic reduction using the trochleocapitellar index. We also correlated the trochleocapitellar index to the functional outcomes next to the comparison of the triceps brachii lifting approach and olecranon osteotomy approach, 2 common approaches for distal humeral fractures...
July 2018: Journal of Shoulder and Elbow Surgery
Daniele Checcarelli, Mauro Zampolini, Michele Berloco, Claudia Fusco, Levent Özçakar
Managing top-level athlete's recovery after an injury is very complicated because it requires a challenging combination of clinical and social/professional aspects with the need to return as soon as possible to sports play. Herein, we report a top-level volleyball player for whom a finger splint combined with a custom made thermoplastic protection was used for the conservative management of a Mallet fracture re-injury. This way our player continued training and competitions in contrast to conventional rehabilitation protocols which suggest to avoid new traumas until the healing phase is completed...
June 13, 2018: American Journal of Physical Medicine & Rehabilitation
Ioannis P Galanopoulos, Andreas F Mavrogenis, Panayiotis D Megaloikonomos, Christos T Vottis, Evanthia Mitsiokapa, Panayiotis Koulouvaris, Dimitrios S Mastrokalos, Panayiotis J Papagelopoulos, Vasilios A Kontogeorgakos
PURPOSE: To compare short with long intramedullary hip nailing for elderly patients with unstable pertrochanteric fractures. METHODS: We prospectively studied 50 patients (33 women, 17 men; mean age, 80 years; range, 74-93 years) with unstable pertrochanteric fractures admitted and treated with a short (group A) or a long (group B) intramedullary hip nail from January 2013 to 2017. The patients were randomly allocated into each group according to their order of admission...
2018: SICOT-J
Qing Zhou, Qingquan Kong, Bo Gao
Objective: To analyze the treatment of Gartland type Ⅱ and Ⅲ supracondylar fracture of the humerus in children. Methods: Between January 2015 and January 2017, 45 cases of Gartland type Ⅱ and Ⅲ supracondylar fracture of the humerus were treated. There were 28 boys and 17 girls with an age of 1-13 years (mean, 5.7 years). The causes of injury included sports injury in 43 cases and falling from height in 2 cases. Fractures were classified as type Ⅱ in 12 cases and type Ⅲ in 33 cases according to Gartland classification...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
Jian Wang, Xiaobo Tang, Peilong Dong, Zhiyun Li
Objective: To explore the effectiveness of high strength suture fixation in treatment of patellar transverse fracture. Methods: Between June 2014 and June 2016, 38 patients with the patellar transverse fracture were treated with high strength suture internal fixation. There were 24 males and 14 females with the age of 26 to 64 years (mean, 45 years). There were 6 cases of accident injury and 32 cases of crashing injury. The time interval between injury and surgery was 2-8 days (mean, 5 days)...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
Gang Li, Lei Chen, Kai Chen
BACKGROUND The aim of this study was to use a rat model of femoral fracture healing to study the effects of curcumin on cell autophagy, compared with treatment with 3-methyladenine (3-MA), an inhibitor of autophagy. MATERIAL AND METHODS Thirty-six Sprague-Dawley rats with right mid-femoral fracture were divided into three groups: the curcumin-treated group (N=12) (gavage with curcumin 400 mg/kg/day); the curcumin + 3-MA-treated group (gavage with curcumin 400 mg/kg/day + 3-MA 30 mg/kg/day); and the control group (N=12) (gavage normal saline)...
June 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Byung-Ho Yoon, Woojin Yu
Bone turnover markers (BTMs) are released during bone remodeling and are thought to reflect the metabolic activity of bone at the cellular level. This review examines BTM as a biological response marker for monitoring future fracture prediction and fracture healing processes. Substantial evidence has been of high value to investigate the use of BTM in fracture risk prediction; nevertheless, the conclusions of some studies are inconsistent due to their large variability. BTM is promising for fracture risk prediction for adopting international reference standards or providing absolute risks, such as 10-year fracture probabilities...
May 2018: Journal of Bone Metabolism
Jean Louis Prudhon, Nicolas Tardy
INTRODUCTION: The trans femoral osteotomy was initially described by Wagner in 1987 and the extended trochanteric osteotomy (ETO) was described by Younger et al. in 1995 and is considered to be the gold standard technique for removal of well-fixed femoral stems in revision total hip arthroplasty (THA). The purpose of this report is: to compare the different types of fixation metallic wires, cables, metallic reinforcement plate (MRP) we have used in revision THA where an ETO was performed; analyse the clinical and radiological outcomes of these devices at 1 year; analyse the complication...
2018: SICOT-J
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