J Michael Wells, Dongqi Xing, Liliana Viera, Robert M Burkes, Yixin Wu, Surya P Bhatt, Mark T Dransfield, David J Couper, Wanda O'Neal, Eric A Hoffman, Amit Gaggar, Igor Barjaktarevic, Jeffrey L Curtis, Wassim W Labaki, Mei Lan K Han, Christine M Freeman, Nirupama Putcha, Thomas Schlange, J Edwin Blalock
BACKGROUND: Pulmonary and systemic inflammation are central features of chronic obstructive pulmonary disease (COPD). Previous studies have demonstrated relationships between biologically active extracellular matrix components, or matrikines, and COPD pathogenesis. We studied the relationships between the matrikine acetyl-proline-glycine-proline (AcPGP) in sputum and plasma and clinical features of COPD. METHODS: Sputum and plasma samples were obtained from COPD participants in the SPIROMICS cohort at enrollment...
November 12, 2019: Respiratory Research