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Endothelin-1

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https://www.readbyqxmd.com/read/29684635/sulfatase-1-mediates-the-attenuation-of-ang-ii-induced-hypertensive-effects-by-ccl5-in-vascular-smooth-muscle-cells-from-spontaneously-hypertensive-rats
#1
Hye Ju Cha, Hye Young Kim, Hee Sun Kim
Extracellular sulfatases, sulfatase 1 (Sulf1) and sulfatase 2 (Sulf2), play a pivotal role in cell signaling and carcinogenesis. Chemokine CCL5 inhibits Ang II-induced hypertensive mediators via angiotensin II (Ang II) type 2 receptor (AT2 R) pathway in vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rats (SHR). In this study, we investigated the effect of Sulfs on anti-hypertensive effects of CCL5 in SHR VSMCs. CCL5 attenuated Ang II-induced inhibition of sulfatase activity in SHR VSMCs...
April 20, 2018: Cytokine
https://www.readbyqxmd.com/read/29684593/renal-function-n-terminal-pro-b-type-natriuretic-peptide-propeptide-big-endothelin-and-patients-with-heart-failure-and-preserved-ejection-fraction
#2
Ingrid Gergei, Bernhard K Krämer, Hubert Scharnagl, Tatjana Stojakovic, Winfried März
Renal dysfunction may limit the clinical application of NT-proBNP in the diagnosis of heart failure. In general practice, where echocardiography is not readily available, a biomarker for the diagnosis of a heart failure with preserved ejection fraction (HFpEF) would be useful. Since cardiac diseases frequently coincide with renal disease, there is a high need of valid risk stratification methods in patients affected with both. We therefore examined NT-proBNP and another biomarker, Big-Endothelin-1, as a marker of HFpEF in patients with CKD...
April 20, 2018: Peptides
https://www.readbyqxmd.com/read/29684255/molecular-profiling-of-post-reperfusion-milieu-determines-acute-kidney-injury-after-liver-transplantation-a-prospective-study
#3
Carlo Pulitano, Phong Ho, Deborah Verran, Charbel Sandroussi, David Joseph, David G Bowen, Geoffrey W McCaughan, Michael Crawford, Nicholas Shackel
Acute kidney injury (AKI) after liver transplantation (LT) is a common event, but its pathogenesis remains unclear. The aim of this prospective study is to investigate the potential relationship between post-reperfusion gene expression, serum mediators, and the onset of AKI after LT. Sixty-five consecutive patients undergoing LT were included in the study. Reverse transcription polymerase chain reaction (RT- PCR), was performed on liver biopsies. Gene expression of 23 genes involved in ischemia reperfusion injury (IRI) was evaluated...
April 23, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29683965/effect-of-dexmedetomidine-on-cerebral-vasospasm-and-associated-biomarkers-in-a-rat-subarachnoid-hemorrhage-model
#4
Young Song, Beom Jin Lim, Do-Hyeong Kim, Jin Woo Ju, Dong Woo Han
BACKGROUND: The α2 adrenergic agonist dexmedetomidine (DEX) has huge potential for protecting against cerebral vasospasm, a leading cause of death and disability after subarachnoid hemorrhage (SAH). Biomarker assays for SAH have recently emerged as tools for predicting vasospasm and outcomes. We investigated the effects of DEX on vasospasm and assessed relevant biomarkers in a rat SAH model. METHODS: Male Wistar rats were randomly assigned to sham (n=10), vehicle (n=10), SAH (n=10), or SAH+ DEX (n=10) groups...
April 20, 2018: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/29678998/acid-stimulation-of-the-citrate-transporter-nadc-1-requires-pyk2-and-erk1-2-signaling-pathways
#5
Miriam Zacchia, Xuefei Tian, Enrica Zona, Robert J Alpern, Patricia A Preisig
Background Urine citrate is reabsorbed exclusively along the renal proximal tubule via the apical Na+ -dicarboxylate cotransporter NaDC-1. We previously showed that an acid load in vivo and media acidification in vitro increase NaDC-1 activity through endothelin-1 (ET-1)/endothelin B (ETB ) signaling. Here, we further examined the signaling pathway mediating acid-induced NaDC-1 activity. Methods We transiently transfected cultured opossum kidney cells, a model of the proximal tubule, with NaDC-1 and ETB and measured [14 C]-citrate uptake after media acidification under various experimental conditions, including inactivation of Pyk2 and c-Src, which were previously shown to be activated by media acidification...
April 20, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29678849/effects-of-adenovirus-mediated-vegf165-gene-therapy-on-myocardial-infarction
#6
Chao Wang, Boya Zhang, Yu Lin, Yang Dong
AIM: To evaluate the role of adenovirus-mediated transduction human VEGF isoform 165 via direct myocardial injection in rats with an occluded circumflex coronary artery, and the possible underlying mechanism. METHODS: Sprague-Dawley rats were induced myocardial infarction (MI) with ligation of the left coronary artery. Rats were randomly divided into 4 groups: 1) the sham group; 2) the MI group; 3) the NS (normal saline) group and 4) the VEGF group. Direct myocardial injection of 0...
March 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29678841/the-effect-of-hyperbaric-oxygen-therapy-on-myocardial-perfusion-after-the-implantation-of-drug-eluting-stents
#7
Yuan Li, Yafeng Hao, Tao Wang, Lingge Wei, Wei Wang, Yi Liang, Xuan Guo
AIM: The study is to investigate hyperbaric oxygen therapy (HBOT) on myocardial perfusion of patients after the implantation of drug-eluting stents (DES) METHODS: From December 2013 to December 2015, a total of 115 patients with CAD who received DES implantation were included in this retrospective study. They were divided into HBOT group (n=55) and control group (n=60) according to different treatments retrospectively. Gated myocardial perfusion single photon emission computed tomography (SPECT) was conducted in all the patients...
March 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29676937/effect-of-magnesium-acetyltaurate-and-taurine-on-endothelin1-induced-retinal-nitrosative-stress-in-rats
#8
Natasha Najwa Nor Arfuzir, Renu Agarwal, Igor Iezhitsa, Puneet Agarwal, Sabrilhakim Sidek, Alexander Spasov, Alexander Ozerov, Nafeeza Mohd Ismail
PURPOSE: Retinal ganglion cell apoptosis in glaucoma is associated with elevated levels of endothelin-1 (ET1), a potent vasoconstrictor. ET1-induced retinal ischemia leads to altered expression of nitric oxide synthase (NOS) isoforms leading to increased formation of nitric oxide (NO) and retinal nitrosative stress. Since magnesium (Mg) is known to improve endothelial functions and reduce oxidative stress and taurine (TAU) possesses potent antioxidant properties, we investigated the protective effects of magnesium acetyltaurate (MgAT) against ET1-induced nitrosative stress and retinal damage in rats...
April 20, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29674204/preeclamptic-plasma-stimulates-the-expression-of-mirnas-leading-to-a-decrease-in-endothelin-1-production-in-endothelial-cells
#9
Mayara Caldeira-Dias, Marcelo R Luizon, Elenice Deffune, Jose E Tanus-Santos, Paula P Freire, Robson F Carvalho, Heloisa Bettiol, Viviane C Cardoso, Marco Antonio Barbieri, Ricardo C Cavalli, Valéria C Sandrim
Preeclampsia is a major cause of maternal and fetal morbidity and mortality worldwide. It is a multisystem pregnancy syndrome characterized by general endothelial dysfunction caused mainly by plasma factors and debris in endothelial cells. It is widely accepted that endothelin-1 (ET-1) is involved in the pathophysiology of preeclampsia, and so it is of interest to ascertain whether the ET-1 gene (EDN1) can be targeted with tools such as miRNAs. Therefore, we investigated the relationship between the expression of miRNAs that putatively target EDN1 (and so affect ET-1 levels) in HUVECs incubated with plasma from preeclamptic women...
March 27, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29665366/3-7-bis-2-hydroxyethyl-icaritin-a-potent-inhibitor-of-phosphodiesterase-5-prevents-monocrotaline-induced-pulmonary-arterial-hypertension-via-no-cgmp-activation-in-rats
#10
Tao-Hua Lan, Xiao-Ling Chen, Yun-Shan Wu, Hui-Liang Qiu, Jun-Zhe Li, Xin-Min Ruan, Dan-Ping Xu, Dong-Qun Lin
Pulmonary arterial hypertension (PAH) is a chronic progressive disease which leads to elevated pulmonary arterial pressure and right heart failure. 3,7-Bis(2-hydroxyethyl)icaritin (ICT), an icariin derivatives, was reported to have potent inhibitory activity on phosphodiesterase type 5 (PDE5) which plays a crucial role in the pathogenesis of PAH. The present study was designed to investigate the effects of ICT on monocrotaline (MCT)-induced PAH rat model and reveal the underlying mechanism. MCT-induced PAH rat models were established with intragastric administration of ICT (10, 20, 40mg/kg/d), Icariin (ICA) (40mg/kg/d) and Sildenafil (25mg/kg/d)...
April 14, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29663576/neuroprotection-by-post-stroke-administration-of-an-oral-formulation-of-angiotensin-1-7-in-ischemic-stroke
#11
Douglas M Bennion, Chad H Jones, Lauren L Donnangelo, Justin T Graham, Jacob D Isenberg, Alex N Dang, Vermali Rodriguez, Ruben D M Sinisterra, Frederico B Sousa, Robson A S Santos, Colin Sumners
NEW FINDINGS: What is the central question of this study? Angiotensin-(1-7) decreases cerebral infarct volume and improves neurological function when delivered centrally prior to and during ischemic stroke. Here, we assessed the neuroprotective effects of angiotensin-(1-7) when delivered orally post-stroke. What is the main finding and its importance? We show that oral delivery of angiotensin-(1-7) attenuates cerebral damage induced by middle cerebral artery occlusion in rats, without affecting blood pressure or cerebral blood flow...
April 16, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29661292/etanercept-restores-vasocontractile-sensitivity-affected-by-mesenteric-ischemia-reperfusion
#12
S Erpulat Ozis, Tamila Akhayeva, Sahika Guner, Sibel S Kilicoglu, Arzu Pampal
BACKGROUND: The aim of the study is to evaluate in vivo and in vitro effects of etanercept, a soluble tumor necrosis factor receptor, on the contractile responses of superior mesenteric artery in an experimental mesenteric ischemia and reperfusion model. MATERIAL AND METHODS: After obtaining animal ethics committee approval, 24 Sprague-Dawley rats were allocated to three groups. Control group (Gr C, n = 6) underwent a sham operation, whereas ischemia/reperfusion and treatment groups underwent 90 min ischemia and 24-h reperfusion (Gr I/R, n = 12; Gr I/R+E, n = 6)...
June 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29660902/effect-of-rho-kinase-inhibitor-fasudil-on-the-expression-et-1-and-no-in-rats-with-hypoxic-pulmonary-hypertension
#13
Xing-Zhen Sun, Shu-Yan Li, Xiang-Yang Tian, Ze Hong, Jia-Xin Li
OBJECTIVE: This study aims to study the effect of Rho kinase inhibitor fasudil on the expression endothelin-1 (ET-1) and nitric oxide (NO) in rats with hypoxic pulmonary hypertension (HPH). METHODS: Twenty-four male SD rats were randomly divided into three groups: control group, model group (HPH group) and HPH+fasudil group. The rat HPH model was established by intermittent hypoxia (IH) at atmospheric pressure. Mean pulmonary artery pressure (mPAP), right ventricular hypertrophy index (RVHI), ET-1 and NO levels, and pulmonary vascular structural changes were observed in all groups...
April 12, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29658585/inhibitors-of-heat-shock-protein-90-augment-endothelin%C3%A2-1%C3%A2-induced-heat-shock-protein-27-through-the-sapk-jnk-signaling-pathway-in-osteoblasts
#14
Kazuhiko Fujita, Takanobu Otsuka, Tetsu Kawabata, Go Sakai, Rie Matsushima-Nishiwaki, Osamu Kozawa, Haruhiko Tokuda
It has been previously reported that endothelin‑1 (ET‑1) stimulates the induction of heat shock protein (HSP) 27 through the activation of p38 mitogen‑activated protein (MAP) kinase and stress‑activated protein kinase/c‑Jun N‑terminal kinase (SAPK/JNK) in osteoblast‑like MC3T3‑E1 cells. The present study investigated whether HSP90, a high‑molecular‑weight HSP, was implicated in the ET‑1‑stimulated HSP27 induction in MC3T3‑E1 cells. The effects of HSP90 inhibitors on the induction of HSP27 were examined...
April 12, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29655692/effects-of-xin-ji-er-kang-on-heart-failure-induced-by-myocardial-infarction-role-of-inflammation-oxidative-stress-and-endothelial-dysfunction
#15
Juan Hu, Pan Cheng, Guang-Yao Huang, Guo-Wei Cai, Feng-Zhen Lian, Xiao-Yun Wang, Shan Gao
BACKGROUND: Xin-Ji-Er-Kang (XJEK) is a Chinese herbal formula, which has been reported to exert effective protection on cardiovascular diseases like hypertension and myocarditis. PURPOSE: To elucidate the protective effects of XJEK on heart failure (HF) induced by myocardial infarction (MI) through the amelioration of inflammation, oxidative stress (OS) and endothelial dysfunction(ED). MATERIALS AND METHODS: Fifty-seven male KM mice were randomized into the following six groups (n = 9-10 for each): control group, model group, MI+XJEK low dose group(XJEKL) group, MI+XJEK middle dose group(XJEKM), MI+XJEK high dose group(XJEKH), and MI+fosinopril group (positive control group)...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29652095/decrease-in-neprilysin-and-vasoconstrictors-and-increase-in-vasodilators-following-bariatric-surgery
#16
Husam Ghanim, Scott Monte, Joseph Caruana, Kelly Green, Sanaa Abuaysheh, Paresh Dandona
Since morbid obesity is associated with congestive cardiac failure and hypertension, and gastric bypass surgery is followed by a reduction in blood pressure and in the risk of congestive cardiac failure, we hypothesized that weight loss following Roux-en-Y gastric bypass (RYGB) surgery in morbidly obese patients is associated with a decrease in plasma concentrations of neprilysin, mediators of renin angiotensin system (RAS), catecholamines and endothelin-1 with an increase in the concentrations of vasodilators...
April 13, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29651618/effect-of-renal-sympathetic-denervation-on-ventricular-and-neural-remodeling
#17
L Wang, G Wei, L Song, C Li, F Zhang, Y Yang, C Lu
BACKGROUND: This study assessed the therapeutic effects of renal sympathetic denervation (RDN) on post-myocardial infarction (MI) ventricular remodeling and sympathetic neural remodeling in dogs. The possible mechanisms and optimal time for treatment are discussed. METHODS: We randomly assigned 30 dogs to five groups: RDN 1 week before MI (RDN1w + MI; n = 6), RDN 1 week after MI (MI1w + RDN; n = 6), RDN 2 weeks after MI (MI2w + RDN; n = 6), control (N; n = 6), and MI (n = 6)...
April 12, 2018: Herz
https://www.readbyqxmd.com/read/29649425/effects-of-grape-consumption-on-biomarkers-of-inflammation-endothelial-function-and-pbmc-gene-expression-in-obese-subjects
#18
Allison S Bardagjy, Qian Hu, Kathryn A Giebler, Addison Ford, Francene M Steinberg
This study investigated effects of grape consumption on biomarkers of cardiovascular health in obese participants in both postprandial and chronic settings. Twenty obese adults participated in this randomized, placebo controlled, double-blinded crossover trial. Participants were randomized to consume 60 g freeze-dried polyphenol-rich whole grape powder (GP) or placebo (PBO) followed by high fat high carbohydrate (HFHC) meal challenge. Following acute challenge, participants consumed their respective treatment daily for 4 weeks to determine effects of chronic consumption...
April 9, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29649319/unraveling-endothelin-1-induced-hypercontractility-of-human-pulmonary-artery-smooth-muscle-cells-from-patients-with-pulmonary-arterial-hypertension
#19
Jamie L Wilson, Rod Warburton, Linda Taylor, Deniz Toksoz, Nicholas Hill, Peter Polgar
Contraction of human pulmonary artery smooth muscle cells (HPASMC) isolated from pulmonary arterial hypertensive (PAH) and normal (non-PAH) subject lungs was determined and measured with real-time electrical impedance. Treatment of HPASMC with vasoactive peptides, endothelin-1 (ET-1) and bradykinin (BK) but not angiotensin II, induced a temporal decrease in the electrical impedance profile mirroring constrictive morphological change of the cells which typically was more robust in PAH as opposed to non-PAH cells...
2018: PloS One
https://www.readbyqxmd.com/read/29648980/cerebrospinal-fluid-endothelin-1-in-severe-traumatic-brain-injury
#20
Hong-Liang Zhang, Jiang Wu
We read with great interest the article by Salonia and colleagues, which reported increased levels of endothelin-1 (ET-1) in the cerebrospinal fluid (CSF) of children with severe traumatic brain injury (TBI), in association with unfavorable outcome (Salonia, et al.). The study was well conducted and the findings are intriguing. However, we wonder if the authors have considered the influence of the blood CSF barrier (B-CSF-B) on the CSF level of ET-1.
March 8, 2018: Journal of Neurotrauma
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