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Endothelin-1

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https://www.readbyqxmd.com/read/29044995/mir-200c-regulates-endothelin-1-induced-pasmcs-abnormal-proliferation-and-apoptosis
#1
Chao Yuan, Min Xu, Rong Rong, Yong Mei, Wenyan Cai, Lin Li, Yao Xue, Baoli Zhu, Kai Sun, Lei Han
miR-200c is an antioncogene in multiple tumors. However, its function in the pathogenesis of pulmonary arterial hypertension (PAH) has not been thoroughly investigated nor understood. In this study, we discovered that miR-200c was able to substantially upregulate in pulmonary arterial smooth muscle cells (PASMCs) treated with endothelin-1 (ET-1). miR-200c also induced cell proliferation and suppressed cell apoptosis in PASMCs in vitro. However, miR-200c had no effect on G1/S/G2 transitions during the cell cycle...
October 16, 2017: IUBMB Life
https://www.readbyqxmd.com/read/29042489/alterations-in-endothelin-type-b-receptor-contribute-to-microvascular-dysfunction-in-women-who-have-had-preeclampsia
#2
Anna E Stanhewicz, Sandeep Jandu, Lakshmi Santhanam, Lacy M Alexander
Microvascular dysfunction originating during a preeclamptic pregnancy persists postpartum and likely contributes to increased CVD risk in these women. One putative mechanism contributing to this dysfunction is increased vasoconstrictor sensitivity to endothelin-1 (ET-1), mediated by alterations in ET-1 receptor type-B (ETBR). We evaluated ET-1 sensitivity, ETAR and ETBR contributions to ET-1-mediated constriction, and the mechanistic role of  ETBR in endothelium-dependent dilation in vivo in the microvasculature of postpartum women who had preeclampsia (PrEC, n=12) and control women who had a healthy pregnancy (HC, n=12)...
October 17, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29034546/bradykinin-system-is-involved-in-endometriosis-related-pain-through-endothelin-1-production
#3
O Yoshino, K Yamada-Nomoto, M Kobayashi, T Andoh, M Hongo, Y Ono, A Hasegawa-Idemitsu, A Sakai, Y Osuga, S Saito
BACKGROUND: Endometriosis is a gynaecological disease exhibiting severe pelvic pain, but the mechanism of pain production remains unknown. Bradykinin (BK) is known as an inflammatory mediator, and shows elevated levels in inflammatory diseases such as rheumatoid arthritis. In the present study, we evaluated whether BK is involved in endometriosis-related pain. METHODS: Endometriotic lesions were used for immunohistochemistry. Primary cultures of endometriotic stromal cells (ESC) were stimulated with IL-1β and/or BK...
October 16, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29028084/expression-and-clinical-significance-of-aquaporin-1-and-et-1-in-urine-of-children-with-congenital-hydronephrosis
#4
Y Yu, Y-F Kang, K-S Li, Z-H Chen, L Zhang, H-M Zhang, M Zhang
OBJECTIVE: Congenital hydronephrosis is induced by congenital obstruction of uretero pelvic junction, bladder vesicoureteral reflux, posterior urethral valve, stricture of ureter end and ureterocyst, which is extremely apt to cause end-stage renal failure in children. It becomes significant to explore the expression profile and clinical significance of aquaporin-1 (AQP-1) and ET-1 (endothelin-1) in the urine of children with congenital hydronephrosis. PATIENTS AND METHODS: 80 cases of children with congenital hydronephrosis were selected to be the observation group and another 40 cases of children with other diseases were served as control group...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29028080/roles-of-hypoxia-inducible-factor-1%C3%AE-and-its-target-genes-in-neonatal-hypoxic-pulmonary-hypertension
#5
C-F Han, Z-Y Li, T-H Li
OBJECTIVE: To investigate the role of hypoxia-inducible factor-1α and its target genes in hypoxic pulmonary hypertension in neonates. PATIENTS AND METHODS: A total of 117 newborns were selected and divided into two groups for clinical experiments: 85 cases in the hypoxic pulmonary hypertension (HPH) group, including mild, moderate and severe subgroups, and 32 cases in the case-control group. ELISA was used to detect the serum HIF-1α, endothelin-1 (ET-1) and adrenomedullin (ADM) levels, and echocardiography was used to detect the dynamic changes in pulmonary artery systolic pressure (PASP), right ventricular ejection fraction (RVEF), tricuspid E peak and A peak ratio (E/A) and right ventricular Tei index...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29018989/effects-of-prior-aerobic-exercise-on-sitting-induced-vascular-dysfunction-in-healthy-men
#6
Kevin D Ballard, Robert M Duguid, Craig W Berry, Priyankar Dey, Richard S Bruno, Rose Marie Ward, Kyle L Timmerman
INTRODUCTION: Acute aerobic exercise prevents sitting-induced impairment of flow-mediated dilation (FMD). Further, evidence suggests that sitting-induced impairment of FMD occurs via an oxidative stress-dependent mechanism that disrupts endothelial function. PURPOSE: We hypothesized that acute aerobic exercise would prevent impairment of femoral artery FMD by limiting oxidative stress responses that increase endothelin-1 (ET-1) levels and disrupt nitric oxide (NO) status...
October 10, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29018813/cardiovascular-consequences-of-repetitive-arousals-over-the-entire-sleep-duration
#7
Yanyan Wu, Rong Huang, Xu Zhong, Yi Xiao
OBJECTIVES: To explore the cardiovascular effects of nightlong repetitive arousals (RA). METHODS: Twenty healthy subjects participated in two consecutive sleep studies. The first one was free of intervention and the second study involved repetitive arousals induced by acoustical stimuli. Blood pressure, heart rate variability (HRV), arterial stiffness index (ASI), and serum markers including nitric oxide (NO), endothelin-1 (ET-1), C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and vascular endothelial growth factor (VEGF) were studied...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28985491/tanshinone-iia-ameliorated-endothelial-dysfunction-in-rats-with-chronic-intermittent-hypoxia
#8
Lingling Chen, Qiu-Hong Guo, Yue Chang, Ya-Shuo Zhao, Ai-Ying Li, En-Sheng Ji
Chronic intermittent hypoxia (CIH) during repetitive airflow cessations may cause endothelial dysfunction. Tanshinone IIA (Tan IIA) has been used to treat various circulatory disturbance-related diseases because of its pharmacological actions, including vasodilation. However, the mechanism of the effect of its vasodilation is not well established. The objective of this study was to explore the effect of Tan IIA in endothelium-dependent contracting factors and endothelin receptors in aortic endothelial dysfunction in CIH rats...
June 30, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/28982333/cerebral-artery-vasoconstriction-is-endothelin-1-dependent-requiring-neurogenic-and-adrenergic-crosstalk
#9
Roel H L Haeren, Sieuwke A Hartmans, Jo De Mey, Govert Hoogland, Jim Dings, Olaf E M G Schijns, Sander M J van Kuijk, Kim Rijkers, Paul Schiffers, Koo J van Overbeeke
BACKGROUND: The regulation of cerebral arterial vasomotor tone involves several mechanisms. The role of sympathetic nerves and the adrenergic neurotransmitter, noradrenaline (NA), has been subject of debate for decades. Moreover, the specific role of endothelin-1 (ET-1) in cerebral arterial vasoconstriction has not been elucidated to date. In this study, we evaluated the contribution of NA and ET-1 to cerebral artery vasoconstriction. METHODS: Arterial responses of rat middle cerebral arteries, and human pial cerebral arteries to cumulative concentrations of NA and ET-1, and to electrical field stimulation (EFS), were evaluated...
October 5, 2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/28981444/central-mediators-of-the-zymosan-induced-febrile-response
#10
Amanda Leite Bastos-Pereira, Daniel Fraga, Arturo Alejandro Dreifuss, Aleksander Roberto Zampronio
BACKGROUND: Zymosan is a fungal cell wall protein-carbohydrate complex that is known to activate inflammatory pathways through the Toll-like receptors and is commonly used to induce fever. Nevertheless, the central mediators that are involved in the zymosan-induced febrile response are only partially known. METHODS: The present study evaluated the participation of prostaglandins, substance P, endothelin-1 (ET-1), and endogenous opioids (eOPs) in the zymosan-induced febrile response by using inhibitors and antagonists in male Wistar rats...
October 5, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28980281/evaluating-the-effects-of-cardiac-resynchronization-therapy-on-pathophysiological-pathways-of-heart-failure-using-surrogate-biomarkers
#11
Hamza Sunman, Adem Özkan, Hikmet Yorgun, Uğur Canpolat, Erdem Karabulut, Tülin Bayrak, Ergün Barış Kaya, Lale Tokgözoğlu, Necla Özer, Asuman Özkara, Kudret Aytemir, Ali Oto
BACKGROUND: Several studies have investigated the effects of cardiac resynchronization therapy (CRT) on heart failure (HF), but none have evaluated the pathophysiological pathways involved in a single group of patients. Therefore, this study aims to assess the long-term effects of CRT on six different pathophysiological pathways involved in the process of HF by the use of surrogate biomarkers. METHODS: In a group 44 patients with HF, six groups of biomarkers were measured, both at baseline and 1 year after CRT implantation: Inflammation (interleukin [IL]-4, IL-6, tumor necrosis factor [TNF]-α, high sensitive C-reactive protein [hsCRP]); oxidative stress (myeloperoxidase, oxidized low-density lipoprotein [oxLDL], uric acid); extracellular matrix (ECM) remodeling (matrix metalloproteinase [MMP]-2 and -9, galectin-3, procollagen III N-terminal propeptide [prokol-3NT]); neurohormonal pathways (endothelin-1, chromogranin-A); myocyte injury (troponin T, creatine kinase MB fraction [CK-MB]), myocyte stress (B-type natriuretic peptide [BNP])...
October 5, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28977804/vascular-dynamics-and-peripheral-oxygen-uptake-in-obese-individuals-during-progressive-physical-exercise
#12
Amelia Brunani, Stefano Lanzi, Franco Codecasa, Mauro Cornacchia, Sabrina Maestrini, Davide Soranna, Antonella Zambon, Stefania Cattaldo, Paolo Fanari, Davide Malatesta, Alberto Salvadori
BACKGROUND: Obese men show higher O2 consumption than lean men during physical exercise, with a trend toward higher peripheral O2 extraction; this is probably due to their larger muscle mass. OBJECTIVES: The aim of this study was to examine this phenomenon by measuring 2 vasoactive substances, endothelin-1 (ET-1) and nitric oxide (NO), during a progressive submaximal exercise. METHODS: Seventeen obese (body mass index [BMI] 38.6) and 15 lean (BMI 22...
October 5, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28976905/endothelin-1-gene-polymorphisms-rs5370-rs1476046-and-rs3087459-are-not-associated-with-diabetic-nephropathy-in-caucasians-with-type-2-diabetes-mellitus
#13
Maja Šeruga, Stojan Kariž, Jana Makuc, Matej Završnik, Ines Cilenšek, Katarina Gazdikova, Martin Caprnda, Peter Kruzliak, Daniel Petrovič
BACKGROUND: Diabetic nephropathy (DN) is a major microvascular complication of type 2 diabetes mellitus (T2DM). Several lines of evidence implicate the endothelin (ET) system in the pathophysiology of DN. The aim of the present study was to analyze if genetic polymorphisms of the ET-1 (EDN1) gene affect susceptibility to DN in Caucasians with T2DM. MATERIALS AND METHODS: The study population consisted of 651 Caucasian subjects with T2DM of more than 10 years' duration: 276 patients with DN (cases) and 375 patients without evidence of DN (controls)...
September 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28975093/association-of-endothelin-1-rs5370-g-t-gene-polymorphism-with-the-risk-of-nephrotic-syndrome-in-children
#14
Mohammad Hashemi, Simin Sadeghi-Bojd, Soheib Aryanezhad, Maryam Rezaei
BACKGROUND: Primary nephrotic syndrome (NS) is a common kidney disease in children. Objectives: The present study was aimed to investigate whether rs5370 G>T (lys198Asn) genetic variant of endothelin-1 (ET-1) is involved in the susceptibility to NS. PATIENTS AND METHODS: This case-control study was performed on 138 patients with NS and 150 healthy children. Genomic DNA was extracted from whole blood using salting out method. Polymorphism of the ET-1 rs5370 G>T (lys198Asn) polymorphism detected by T-ARMS-PCR as well as PCR-RFLP method...
July 2017: Journal of Nephropathology
https://www.readbyqxmd.com/read/28971844/traf3ip2-mediates-high-glucose-induced-endothelin-1-production-as-well-as-endothelin-1-induced-inflammation-in-endothelial-cells
#15
Jaume Padilla, Andrea Carpenter, Nitin Das Das, Hemanth K Kandikattu, Susana Lopez-Ongil, Luis A Martinez-Lemus, Ulrich Siebenlist, Vincent G DeMarco, Bysani Chandrasekar
Hyperglycemia-induced production of endothelin-1 (ET-1) is a hallmark of endothelial dysfunction in diabetes. While the detrimental vascular effects of increased ET-1 are well-known, the molecular mechanisms regulating endothelial synthesis of ET-1 in the setting of diabetes remain largely unidentified. Here we show that adapter molecule TRAF3 Interacting Protein 2 (TRAF3IP2) mediates high glucose-induced ET-1 production in endothelial cells and ET-1-mediated endothelial cell inflammation. Specifically, we found that high glucose upregulated TRAF3IP2 in human aortic endothelial cells, which subsequently led to activation of c-Jun N-terminal kinase (JNK) and IκB kinase beta (IKKβ)...
September 29, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28971608/pharmacological-hypothesis-nitric-oxide-induced-inhibition-of-adam-17-activity-as-well-as-vesicle-release-can-in-turn-prevent-the-production-of-soluble-endothelin-converting-enzyme
#16
REVIEW
Sanjaya Kuruppu, Niwanthi W Rajapakse, Helena C Parkington, Ian Smith
Endothelin-1 (ET-1) and nitric oxide (NO) are two highly potent vasoactive molecules with opposing effects on the vasculature. Endothelin-converting enzyme (ECE) and nitric oxide synthase (NOS) catalyse the production of ET-1 and NO, respectively. It is well established that these molecules play a crucial role in the initiation and progression of cardiovascular diseases and have therefore become targets of therapy. Many studies have examined the mechanism(s) by which NO regulates ET-1 production. Expression and localization of ECE-1 is a key factor that determines the rate of ET-1 production...
October 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28964752/inhibition-of-nkcc1-promotes-axonal-growth-and-motor-recovery-in-ischemic-rats
#17
X P Mu, H B Wang, X Cheng, L Yang, X Y Sun, H L Qu, S S Zhao, Z K Zhou, T T Liu, T Xiao, B Song, J Jolkkonen, C S Zhao
Bumetanide is a selective inhibitor of the Na(+)-K(+)-Cl(-)-co-transporter 1(NKCC1). We studied whether bumetanide could affect axonal growth and behavioral outcome in stroke rats. Adult male Wistar rats were randomly assigned to four groups: sham-operated rats treated with vehicle or bumetanide, and ischemic rats treated with vehicle or bumetanide. Endothelin-1 was used to induce focal cerebral ischemia. Bumetanide administration (i.c.v.) started on postoperative day 7 and continued for 3 weeks. Biotinylated dextran amine (BDA) was injected into the right imotor cortex on postoperative day 14 to trace corticospinal tract (CST) fibers sprouting into the denervated cervical spinal cord...
September 28, 2017: Neuroscience
https://www.readbyqxmd.com/read/28960333/the-pruritogenic-mediator-endothelin-1-shifts-the-dendritic-cell-t-cell-response-toward-th17-th1-polarization
#18
T Nakahara, M Kido-Nakahara, F Ohno, D Ulzii, T Chiba, G Tsuji, M Furue
Endothelin-1 (ET-1) is associated with skin diseases such as atopic dermatitis (AD) and psoriasis. ET-1 is enhanced in the skin of patients AD and psoriasis. In addition, plasma levels of ET-1 are elevated in AD and psoriasis. Although both AD and psoriasis are T-cell-mediated skin diseases, the association between ET-1 and the T-cell immune response has not been clarified. To evaluate the role of ET-1 in inflammatory skin disease, we sought to investigate the effects of ET-1 on the functions of dendritic cells (DCs) and subsequent immune responses...
September 27, 2017: Allergy
https://www.readbyqxmd.com/read/28957531/fibroblasts-and-the-extracellular-matrix-in-right-ventricular-disease
#19
Nikolaos G Frangogiannis
Right ventricular failure predicts adverse outcome in patients with pulmonary hypertension (PH), and in subjects with left ventricular heart failure and is associated with interstitial fibrosis. This review manuscript discusses the cellular effectors and molecular mechanisms implicated in right ventricular fibrosis. The right ventricular interstitium contains vascular cells, fibroblasts, and immune cells, enmeshed in a collagen-based matrix. Right ventricular pressure overload in PH is associated with the expansion of the fibroblast population, myofibroblast activation, and secretion of extracellular matrix proteins...
October 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28949445/impact-of-selective-anti-bmp9-treatment-on-tumor-cells-and-tumor-angiogenesis
#20
(no author information available yet)
The role of bone morphogenic protein 9 (BMP9) signaling in angiogenesis has been controversial, with a number of studies showing that it acts either as a pro-angiogenic or, conversely, as an anti-angiogenic factor in a context-dependent manner. Notably, BMP9 was also reported to function in both pro- or anti-tumorigenic roles during tumor progression. It has therefore remained unclear, whether selective BMP9 inhibition is a useful target for antibody therapy of cancer. To shed light on these questions, we characterized BMP9 expression in plasma of patients with different cancer indications and found elevated levels of pro-domains and precursor BMP9 with a strong response in renal cell carcinoma (RCC)...
December 2016: Molecular Oncology
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