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https://www.readbyqxmd.com/read/29042301/towards-a-first-implementation-of-the-wlimes-approach-in-living-system-studies-advancing-the-diagnostics-and-therapy-in-personalized-medicine
#1
Plamen L Simeonov, Andrée C Ehresmann
The goal of this paper is to advance an extensible theory of living systems using an approach to biomathematics and biocomputation that suitably addresses self-organized, self-referential and anticipatory systems with multi-temporal multi-agents. Our first step is to provide foundations for modelling of emergent and evolving dynamic multi-level organic complexes and their sustentative processes in artificial and natural life systems. Main applications are in life sciences, medicine, ecology and astrobiology, as well as robotics, industrial automation, man-machine interface and creative design...
October 14, 2017: Bio Systems
https://www.readbyqxmd.com/read/29034649/implementation-a-medical-simulation-curriculum-in-emergency-medicine-residency-program
#2
Amirhossein Jahanshir, Maryam Bahreini, Mohsen Banaie, Mohammad Jallili, Shahram Hariri, Fatemeh Rasooli, Hamed Sotoodehnia, Javad Seyed Hosseini, Arash Safaie, Ehsan Karimi, Ali Labaf, Hadi Mir Fazaelian, Elnaz Vahidi
Applying simulation in medical education is becoming more and more popular. The use of simulation in medical training has led to effective learning and safer care for patients. Nowadays educators have confronted with the challenge of respecting patient safety or bedside teaching. There is widespread evidence, supported by robust research, systematic reviews and meta-analysis, on how much effective simulation is. Simulation supports the acquisition of procedural, technical and non-technical skills through repetitive practice with feedbacks...
August 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29032590/a-scoping-approach-to-systematically-review-published-reviews-adaptations-and-recommendations
#3
REVIEW
Annette Schultz, Leah Goertzen, Janet Rothney, Pamela Wener, Jennifer Enns, Gayle Halas, Alan Katz
Knowledge translation is a central focus of the health research community, which includes strategies to synthesize published research to support uptake within healthcare practice and policy arenas. Within the literature concerning review methodologies, a new discussion has emerged concerning methods that review and synthesize published review articles. In this paper, our multidisciplinary team from family medicine, nursing, dental hygiene, kinesiology, occupational therapy, physiology, population health, clinical psychology and library sciences contribute to this discussion by sharing our experiences in conducting three scoping reviews of published review studies...
October 15, 2017: Research Synthesis Methods
https://www.readbyqxmd.com/read/29026060/unmet-needs-in-health-training-among-nurses-in-rural-chinese-township-health-centers-a-cross-sectional-hospital-based-study
#4
Yan Mo, Guijie Hu, Yanhua Yi, Yanping Ying, Huiqiao Huang, Zhongxian Huang, Jiafeng Lin
Purpose: Maintaining a sufficient and competent rural nursing workforce is important in Chinese health delivery system. However, few studies have involved in the health training status and needs assessment of rural Chinese nurses in great transformations of health policy. This study is to explore the current health training status and to ascertain needs perceived by nurses working in rural Chinese township health centers (THCs). Methods: A cross-sectional survey using a self-administered structured questionnaire was conducted to 240 THC nurses in Guangxi Zhuang Autonomous region, China from March 2014 to August 2014...
October 4, 2017: Journal of Educational Evaluation for Health Professions
https://www.readbyqxmd.com/read/29025526/hospital-acquired-urinary-tract-infections-results-of-a-cohort-study-performed-in-an-internal-medicine-department
#5
Maria João Lobão, Paulo Sousa
INTRODUCTION: Urinary tract infections are the most frequent healthcare associated infections, being related to both high costs and morbidity. Our intention was to carry out an epidemiological characterization of hospital acquired urinary tract infections that occurred in an internal medicine department of a Portuguese hospital. MATERIAL AND METHODS: Retrospective cohort study (historic cohort). Data were analysed from a systematic random sample of 388 patients, representative of the 3492 admissions occurred in 2014 in that department...
September 29, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29025360/best-practice-of-identification-and-proteomic-analysis-of-extracellular-vesicles-in-human-health-and-disease
#6
Barbara W Sódar, Árpád Kovács, Tamás Visnovitz, Éva Pállinger, Károly Vékey, Gabriella Pocsfalvi, Lilla Turiák, Edit I Buzás
Extracellular vesicles are emerging sources of biomarkers for modern preventive and precision medicine. Extracellular vesicles in body fluids offer a unique opportunity for integrative biomarker approaches due to their complex biocargo that includes proteins, lipids, nucleic acids and metabolites. Mass spectrometry-based proteomics data suggest that a significant portion of human proteins are sorted into extracellular vesicles and amenable for biomarker discovery schemes. Areas covered: this review focuses on key aspects of isolation, quality control and subsequent analysis of blood plasma- and conditioned medium-derived extracellular vesicle proteins, and summarizes the current state-of-the-art in the field...
October 13, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/29022563/statistical-medicine-an-emerging-medical-specialty
#7
A Indrayan
A large number of statistical tools are now used for medical decision in the core activities of diagnosis, treatment and prognosis. These tools provide undeniable help in improving medical outcomes. Prominent among them are uncertainty measurement by probability, medical indicators and indexes, reference ranges, and scoring systems. In addition are tools such as odds ratio, sensitivity, specificity and predictivities, area under the ROC curve, likelihood ratios, and cost-benefit analysis that are commonly applied in medical research but have implications for day-to-day clinical activities...
October 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/29019353/hot-news-ready-for-hiv-dual-therapy-new-data-from-international-hiv-aids-society-2017
#8
George A Yendewa, Robert A Salata
The introduction of combination antiretroviral therapy (ART) in the 1990s has fundamentally transformed the landscape of HIV medicine, greatly improved disease morbidity and mortality, and reduced transmission rates across all demographic groups. Central to this success was the idea that to achieve best disease outcomes and minimize the development of drug resistance, at least three antiretroviral agents should be used for HIV treatment. This therapeutic strategy is a core tenet of HIV medicine, backed by incontrovertible scientific evidence, and made easy to deploy by the high compliance levels with once-daily coformulations, which have generally been well tolerated...
October 11, 2017: AIDS Reviews
https://www.readbyqxmd.com/read/29017473/australian-consumer-perspectives-attitudes-and-behaviours-on-antibiotic-use-and-antibiotic-resistance-a-qualitative-study-with-implications-for-public-health-policy-and-practice
#9
Elaine P M Lum, Katie Page, Lisa Nissen, Jenny Doust, Nicholas Graves
BACKGROUND: Consumers receive over 27 million antibiotic prescriptions annually in Australian primary healthcare. Hence, consumers are a key group to engage in the fight against antibiotic resistance. There is a paucity of research pertaining to consumers in the Australian healthcare environment. This study aimed to investigate the perspectives, attitudes and behaviours of Australian consumers on antibiotic use and antibiotic resistance, to inform national programs for reducing inappropriate antibiotic consumption...
October 10, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29016553/bleeding-and-neurologic-complications-in-58-000-interventional-pain-procedures
#10
Nafisseh S Warner, W Michael Hooten, Matthew A Warner, Tim J Lamer, Jason S Eldrige, Halena M Gazelka, Daryl J Kor, Bryan C Hoelzer, William D Mauck, Susan M Moeschler
BACKGROUND AND OBJECTIVES: Interventional pain procedures are commonly performed on patients receiving antiplatelet therapy. However, there is limited evidence to support or refute the safety of this practice. The goal of this investigation was to assess the rate of bleeding complications in a large cohort of patients undergoing intermediate- and low-risk pain procedures, with a specific focus on antiplatelet and anticoagulant medication use and baseline coagulation abnormalities. METHODS: This is a retrospective cohort study of adult patients undergoing low- and intermediate-risk pain procedures from 2005 through 2014 by the division of pain medicine at a single academic tertiary care center...
October 6, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29016516/barriers-to-effective-teamwork-relating-to-pediatric-resuscitations-perceptions-of-pediatric-emergency-medicine-staff
#11
Joshua M Sherman, Todd P Chang, Nurit Ziv, Alan L Nager
BACKGROUND: In the pediatric emergency department (PED), resuscitations require medical teams form ad hoc, rarely communicating beforehand. Literature has shown that the medical community has deficiencies in communication and teamwork. However, we as medical providers do not know or understand the perceived barriers of our colleagues. Physicians may perceive a barrier that is different from nurses, respiratory therapists, pharmacists, or technicians. Perhaps we do not know in which area of teamwork and communication we are deficient...
October 9, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28992873/the-rapid-disaster-evaluation-system-rades-a-plan-to-improve-global-disaster-response-by-privatizing-the-assessment-component
#12
Kenneth V Iserson
BACKGROUND: Emergency medicine personnel frequently respond to major disasters. They expect to have an effective and efficient management system to elegantly allocate available resources. Despite claims to the contrary, experience demonstrates this rarely occurs. OBJECTIVES: This article describes privatizing disaster assessment using a single-purposed, accountable, and well-trained organization. The goal is to achieve elegant disaster assessment, rather than repeatedly exhorting existing groups to do it...
September 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28991842/medical-school-factors-that-prepare-students-to-become-leaders-in-medicine
#13
Louise Arnold, Paul G Cuddy, Susan B Hathaway, Jennifer L Quaintance, Steven L Kanter
PURPOSE: To identify medical school factors graduates in major leadership positions perceive as contributing to their leadership development. METHOD: Using a phenomenological, qualitative approach, in August-November 2015 the authors conducted semistructured interviews with 48 medical leaders who were 1976-1999 baccalaureate-MD graduates of the University of Missouri-Kansas City School of Medicine (UMKC). At UMKC, they participated in longitudinal learning communities, the centerpiece for learning professional values and behaviors plus clinical skills, knowledge, and judgment, but received no formal leadership instruction...
October 3, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28989095/risk-factors-and-prevention-of-hepatocellular-carcinoma-in-the-era-of-precision-medicine
#14
REVIEW
Naoto Fujiwara, Scott L Friedman, Nicolas Goossens, Yujin Hoshida
Chronic fibrotic liver disease caused by viral or metabolic etiologies is a high-risk condition for developing hepatocellular carcinoma (HCC). Even after complete HCC tumor resection or ablation, the carcinogenic tissue microenvironment in the remnant liver can give rise to recurrent de novo HCC tumors, which progress into incurable, advanced-stage disease in the majority of patients. Thus, early detection and prevention of HCC development is, in principle, the most impactful strategy to improve patient prognosis...
October 5, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28986192/effect-of-antibiotics-for-infectious-diarrhea-on-the-duration-of%C3%A2-hospitalization-a-retrospective-cohort-study-at-a-single-center%C3%A2-in%C3%A2-japan-from-2012-to-2015
#15
Yosuke Sasaki, Yoshitaka Murakami, Hiroaki Zai, Hitoshi Nakajima, Yoshihisa Urita
OBJECTIVE: Routine empirical antimicrobial therapy for patients with infectious diarrhea is not recommended in general practice. Conversely, prescription of empirical antibiotics for hospitalized patients remains controversial due to a lack of studies providing evidence for its benefits. Thus, this study aimed to examine whether empirical antimicrobial therapy would shorten the hospitalization duration for infectious diarrhea patients. METHODS: This single-center, retrospective cohort study was performed at the Department of General Medicine and Emergency Care, Toho University Medical Center Omori Hospital, using medical records...
October 3, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28985994/from-mundane-medicines-to-euphorigenic-drugs-how-pharmaceutical-pleasures-are-initiated-foregrounded-and-made-durable
#16
Henry Bundy, Gilbert Quintero
BACKGROUND: Examining how pharmaceuticals are used to induce pleasure presents a unique opportunity for analyzing not only how pleasure is assembled and experienced through distinct consumption practices but also how mundane medicines can become euphorigenic substances. METHODS: Drawing on qualitative research on the non-medical use of prescription drugs by young adults in the United States, this paper utilizes Actor-Network Theory (ANT) to examine how prescription medicines come to produce pleasure...
October 3, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28985293/qualitative-research-on-infertile-chinese-couples-understanding-of-sexuality
#17
Wang Zhuoran, Liu Wanpeng, Peng Tao, Rosemary Coates
Background: Family physicians play an important role in the initial counselling and evaluation of infertility. Despite infertility regarded as a stressor and a life crisis for individuals or couples, little is known about the psychosexual aspects of infertility. On the basis that sexuality is a crucial part of quality of life, it is worthwhile to give more attention to sexuality of infertile couples during their time of experiencing infertility. Objective: This study aimed to gain insight into the dynamic features of the sexuality of infertile couples and to provide meaningful evidence for improving their quality of life...
July 23, 2017: Family Practice
https://www.readbyqxmd.com/read/28984353/care-maps-for-children-with-medical-complexity
#18
Sherri Adams, David Nicholas, Sanjay Mahant, Natalie Weiser, Ronik Kanani, Katherine Boydell, Eyal Cohen
AIM: Children with medical complexity require multiple providers and services to keep them well and at home. A care map is a patient/family-created diagram that pictorially maps out this complex web of services. This study explored what care maps mean for families and healthcare providers to inform potential for clinical use. METHOD: Parents (n=15) created care maps (hand drawn n=10 and computer-generated n=5) and participated in semi-structured interviews about the process of developing care maps and their perceived impact...
October 6, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28981996/clinical-vignettes-inadequate-to-assess-impact-of-implicit-bias-concerning-limitations-of-a-systematic-review
#19
Elizabeth A Samuels, Dowin H Boatright, Leon Sanchez, Sheryl Heron, Aisha T Liferidge, Taneisha Wilson, Ava Pierce, Alden Landry, Lisa Moreno-Walton, Jeffrey Druck, Joel Moll, Bernard Lopez
We are writing in response to Dehon et al's article "A Systematic Review of the Impact of Physician Implicit Racial Bias on Clinical Decision Making"(1) in the August 2017 issue of Academic Emergency Medicine. As members of SAEM's Academy of Diversity and Inclusion in Emergency Medicine, we believe it is imperative to pursue research on the impact of bias and discrimination on clinical practice and healthcare outcomes. While we commend Dr. Dehon and her colleagues for their effort to assess the impact of implicit bias on clinical decision-making, we do not think that the evidence reviewed supports the breadth of their conclusions...
October 5, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28981459/high-resolution-nmr-spectroscopy-as-a-structural-and-analytical-tool-for-unsaturated-lipids-in-solution
#20
REVIEW
Eleni Alexandri, Raheel Ahmed, Hina Siddiqui, Muhammad I Choudhary, Constantinos G Tsiafoulis, Ioannis P Gerothanassis
Mono- and polyunsaturated lipids are widely distributed in Nature, and are structurally and functionally a diverse class of molecules with a variety of physicochemical, biological, medicinal and nutritional properties. High resolution NMR spectroscopic techniques including 1H-, 13C- and 31P-NMR have been successfully employed as a structural and analytical tool for unsaturated lipids. The objective of this review article is to provide: (i) an overview of the critical 1H-, 13C- and 31P-NMR parameters for structural and analytical investigations; (ii) an overview of various 1D and 2D NMR techniques that have been used for resonance assignments; (iii) selected analytical and structural studies with emphasis in the identification of major and minor unsaturated fatty acids in complex lipid extracts without the need for the isolation of the individual components; (iv) selected investigations of oxidation products of lipids; (v) applications in the emerging field of lipidomics; (vi) studies of protein-lipid interactions at a molecular level; (vii) practical considerations and (viii) an overview of future developments in the field...
October 5, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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