keyword
Keywords Operative treatment versus non...

Operative treatment versus non operative treatment in rectal cancer

https://read.qxmd.com/read/38127627/anal-adenocarcinoma-treated-in-the-era-of-total-neoadjuvant-therapy-and-nonoperative-management
#1
JOURNAL ARTICLE
Yael Feferman, Roni Rosen, Selim Gebran, Jonathan B Yuval, Marion Kerioui, Mithat Gonen, Iris H Wei, Maria Widmar, Garrett M Nash, Martin R Weiser, Philip B Paty, Carla Hajj, Diana Roth O'Brien, Paul B Romesser, Christopher Crane, J Joshua Smith, Julio Garcia Aguilar, Emmanouil P Pappou
BACKGROUND: Anal adenocarcinoma bears a treatment strategy unique to other anal cancers. OBJECTIVE: To describe oncologic outcomes of total neoadjuvant therapy followed by watch and wait for anal adenocarcinoma. DESIGN: Retrospective analysis. SETTING: This study was conducted at a comprehensive cancer center. PATIENTS: Patients with anal adenocarcinoma treated between 2004 to 2019 were selected...
December 21, 2023: Diseases of the Colon and Rectum
https://read.qxmd.com/read/37452176/development-and-multicenter-validation-of-a-multiparametric-imaging-model-to-predict-treatment-response-in-rectal-cancer
#2
JOURNAL ARTICLE
Niels W Schurink, Simon R van Kranen, Joost J M van Griethuysen, Sander Roberti, Petur Snaebjornsson, Frans C H Bakers, Shira H de Bie, Gerlof P T Bosma, Vincent C Cappendijk, Remy W F Geenen, Peter A Neijenhuis, Gerald M Peterson, Cornelis J Veeken, Roy F A Vliegen, Femke P Peters, Nino Bogveradze, Najim El Khababi, Max J Lahaye, Monique Maas, Geerard L Beets, Regina G H Beets-Tan, Doenja M J Lambregts
OBJECTIVES: To develop and validate a multiparametric model to predict neoadjuvant treatment response in rectal cancer at baseline using a heterogeneous multicenter MRI dataset. METHODS: Baseline staging MRIs (T2W (T2-weighted)-MRI, diffusion-weighted imaging (DWI) / apparent diffusion coefficient (ADC)) of 509 patients (9 centres) treated with neoadjuvant chemoradiotherapy (CRT) were collected. Response was defined as (1) complete versus incomplete response, or (2) good (Mandard tumor regression grade (TRG) 1-2) versus poor response (TRG3-5)...
July 14, 2023: European Radiology
https://read.qxmd.com/read/37431270/predicting-rectal-cancer-response-to-total-neoadjuvant-treatment-using-an-artificial-intelligence-model-based-on-magnetic-resonance-imaging-and-clinical-data
#3
JOURNAL ARTICLE
Ganlu Ouyang, Zhebin Chen, Meng Dou, Xu Luo, Han Wen, Xiangbing Deng, Wenjian Meng, Yongyang Yu, Bing Wu, Dan Jiang, Ziqiang Wang, Yu Yao, Xin Wang
PURPOSE: To develop a model for predicting response to total neoadjuvant treatment (TNT) for patients with locally advanced rectal cancer (LARC) based on baseline magnetic resonance imaging (MRI) and clinical data using artificial intelligence methods. METHODS: Baseline MRI and clinical data were curated from patients with LARC and analyzed using logistic regression (LR) and deep learning (DL) methods to predict TNT response retrospectively. We defined two groups of response to TNT as pathological complete response (pCR) versus non-pCR (Group 1), and high sensitivity [tumor regression grade (TRG) 0 and TRG 1] versus moderate sensitivity (TRG 2 or patients with TRG 3 and a reduction in tumor volume of at least 20% compared to baseline) versus low sensitivity (TRG 3 and a reduction in tumor volume <20% compared to baseline) (Group 2)...
2023: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/37079715/survival-outcomes-for-patients-with-colorectal-cancer-with-synchronous-liver-only-metastasis
#4
JOURNAL ARTICLE
Mia Shepherdson, Daniel Kilburn, Shahid Ullah, Timothy Price, Christos S Karapetis, Peter Nguyen, Amanda Townsend, Robert Padbury, Cynthia Piantadosi, Guy Maddern, Scott Carruthers, David Roder, Michael Sorich, Amitesh C Roy
BACKGROUND: Colorectal cancer with synchronous liver-only metastasis is managed with a multimodal approach, however, optimal sequencing of modalities remains unclear. METHODS: A retrospective review of all consecutive rectal or colon cancer cases with synchronous liver-only metastasis was conducted from the South Australian Colorectal Cancer Registry from 2006 to 2021. This study aimed to investigate how order and type of treatment modality affects overall survival...
April 20, 2023: ANZ Journal of Surgery
https://read.qxmd.com/read/37011059/implications-of-the-new-mri-based-rectum-definition-according-to-the-sigmoid-take-off-multicentre-cohort-study
#5
MULTICENTER STUDY
Thijs A Burghgraef, Jeroen C Hol, Marieke L Rutgers, Gina Brown, Roel Hompes, Colin Sietses, Esther C J Consten
BACKGROUND: The introduction of the sigmoid take-off definition might lead to a shift from rectal cancers to sigmoid cancers. The aim of this retrospective cohort study was to determine the clinical impact of the new definition. METHODS: In this multicentre retrospective cohort study, patients were included if they underwent an elective, curative total mesorectal excision for non-metastasized rectal cancer between January 2015 and December 2017, were registered in the Dutch Colorectal Audit as having a rectal cancer according to the previous definition, and if MRI was available...
March 7, 2023: BJS Open
https://read.qxmd.com/read/36999800/changing-trends-clinicopathological-characteristics-surgical-treatment-patterns-and-prognosis-of-schistosomiasis-associated-versus-non-schistosomiasis-associated-colorectal-cancer-a-large-retrospective-cohort-study-of-31-153-cases-in-shanghai-china-2001-2021
#6
JOURNAL ARTICLE
Nanxin Zheng, Hao Wang, Qing Yu, Chen Wang, Chen Guang Bai, An Fu Pan, Jianjun Jiang, Jian Lu, Si Min Dai, Zubing Mei, Wei Zhang, Xian Hua Gao
BACKGROUND: With the elimination of schistosomiasis in China, its role in the pathogenesis of colorectal cancer (CRC) has decreased. However, the trends, clinicopathological features, surgical treatment patterns, and prognosis of schistosomiasis-associated CRC (SACRC) versus non-schistosomiasis-associated CRC (NSACRC) in China remain unclear. MATERIALS AND METHODS: The percentage trend of SACRC in CRC patients in China was analyzed using data retrieved from the Pathology Registry of Changhai Hospital (2001-2021)...
April 3, 2023: International Journal of Surgery
https://read.qxmd.com/read/36577551/star-trec-an-international-three-arm-multicentre-partially-randomised-controlled-trial-incorporating-an-external-pilot
#7
JOURNAL ARTICLE
S P Bach
AIM: Organ saving treatment for early-stage rectal cancer can reduce patient reported side effects compared to standard total mesorectal excision (TME) and preserve quality of life (QOL). An optimal strategy for achieving organ preservation and longer-term oncological outcomes are unknown, thus there is a need for high quality trials. METHOD: Can we Save the rectum by watchful waiting or TransAnal surgery following (chemo)Radiotherapy versus Total mesorectal excision for early REctal Cancer (STAR-TREC) is an international 3-arm multi-centre, partially randomised controlled trial incorporating an external pilot...
December 26, 2022: Clinical Oncology: a Journal of the Royal College of Radiologists
https://read.qxmd.com/read/36551723/associations-between-response-to-commonly-used-neo-adjuvant-schedules-in-rectal-cancer-and-routinely-collected-clinical-and-imaging-parameters
#8
JOURNAL ARTICLE
Masoud Karimi, Pia Osterlund, Klara Hammarström, Israa Imam, Jan-Erik Frodin, Bengt Glimelius
Complete pathological response (pCR) is achieved in 10-20% of rectal cancers when treated with short-course radiotherapy (scRT) or long-course chemoradiotherapy (CRT) and in 28% with total neoadjuvant therapy (scRT/CRT + CTX). pCR is associated with better outcomes and a "watch-and-wait" strategy (W&W). The aim of this study was to identify baseline clinical or imaging factors predicting pCR. All patients with preoperative treatment and delays to surgery in Uppsala-Dalarna ( n = 359) and Stockholm ( n = 635) were included...
December 18, 2022: Cancers
https://read.qxmd.com/read/36535196/comparison-of-short-course-radiotherapy-with-chemoradiotherapy-for-locally-advanced-rectal-cancers-in-the-elderly-a-multicentre-randomised-non-blinded-phase-3-trial
#9
RANDOMIZED CONTROLLED TRIAL
Eric François, Berardino De Bari, Philippe Ronchin, Elodie Nouhaud, Isabelle Martel-Lafay, Pascal Artru, Pierre Clavere, Veronique Vendrely, Valerie Boige, Deny Gargot, Claire Lemanski, Nicolas De Sousa Carvalho, Jocelyn Gal, Mandy Pernot, Nicolas Magné
BACKGROUND: There is no specific guideline for the treatment of locally advanced rectal cancers in the elderly. Here we compared R0 resection rate and degradation of autonomy based on the instrumental activities of daily living score between neoadjuvant, short course radiotherapy and chemoradiotherapy in this specific population. PATIENTS AND METHODS: Patients ≥75 years with resectable T3-T4 rectal adenocarcinoma within 12 cm of the anal verge or T2 of the very low rectum were randomised between short course radiotherapy (5 × 5 Gy in one week) and chemoradiotherapy (50 Gy, 2 Gy/f, 5 weeks with capecitabine: 800 mg/m2 twice daily, 5 days per week), with delayed surgery 7 ± 1 weeks for the two arms...
February 2023: European Journal of Cancer
https://read.qxmd.com/read/35694967/laparoscopic-versus-open-lateral-pelvic-lymph-node-dissection-in-locally-advanced-rectal-cancer-multicentre-retrospective-cohort-study
#10
MULTICENTER STUDY
Han-Ki Lim, Minjung Kim, Ji Won Park, Seung-Bum Ryoo, Kyu Joo Park, Heung-Kwon Oh, Duck-Woo Kim, Sung-Bum Kang, Dong Woon Lee, Sung Chan Park, Jae Hwan Oh, Seung-Yong Jeong
BACKGROUND: Lateral pelvic lymph node dissection (LPLND) is an option in the treatment of rectal cancer and may reduce local recurrence/improve disease-free survival. Advancements in minimally invasive technology have improved the ability to identify anatomy and neurovascular structures that may help in LPLND. The aim of this retrospective study was to evaluate the technical feasibility and oncological safety of laparoscopic LPLND compared with the open LPLND. METHOD: Between July 2010 and July 2019, patients from three tertiary referral hospitals who underwent LPLND with total mesorectal excision for primary rectal cancer were included...
May 2, 2022: BJS Open
https://read.qxmd.com/read/35114057/can-we-save-the-rectum-by-watchful-waiting-or-transanal-surgery-following-chemo-radiotherapy-versus-total-mesorectal-excision-for-early-rectal-cancer-star-trec-protocol-for-the-international-multicentre-rolling-phase-ii-iii-partially-randomized-patient-preference
#11
JOURNAL ARTICLE
Simon P Bach
AIM: Organ-saving treatment for early-stage rectal cancer can reduce patient-reported side effects compared to standard total mesorectal excision (TME) and preserve quality of life. An optimal strategy for achieving organ preservation and longer-term oncological outcomes are unknown; thus there is a need for high quality trials. METHOD: Can we Save the rectum by watchful waiting or TransAnal surgery following (chemo)Radiotherapy versus Total mesorectal excision for early REctal Cancer (STAR-TREC) is an international three-arm multicentre, partially randomized controlled trial incorporating an external pilot...
May 2022: Colorectal Disease
https://read.qxmd.com/read/35040944/quality-of-life-in-restorative-versus-non-restorative-resections-for-rectal-cancer-systematic-review
#12
JOURNAL ARTICLE
Samuel Lawday, Nicholas Flamey, George E Fowler, Matthew Leaning, Nadine Dyar, Ian R Daniels, Neil J Smart, Christopher Hyde
BACKGROUND: Low rectal cancers could be treated using restorative (anterior resection, AR) or non-restorative procedures with an end/permanent stoma (Hartmann's, HE; or abdominoperineal excision, APE). Although the surgical choice is determined by tumour and patient factors, quality of life (QoL) will also influence the patient's future beyond cancer. This systematic review of the literature compared postoperative QoL between the restorative and non-restorative techniques using validated measurement tools...
November 9, 2021: BJS Open
https://read.qxmd.com/read/34967578/propensity-score-matched-analysis-of-laparoscopic-versus-open-surgery-for-non-metastatic-rectal-cancer
#13
COMPARATIVE STUDY
Kanittha Sakolprakaikij, Kamthorn Yolsuriyanwong, Piyanun Wangkulangkul, Praisuda Bwaloy, Siripong Cheewatanakornkul
BACKGROUND: Rectal cancer is a pervasive type of malignancy that accounts for one-third of colorectal cancers worldwide. Several studies have assessed the use of laparoscopic surgery as a treatment option. However, there is an ongoing debate regarding its oncological safety. METHODS: This retrospective study included 270 patients with non-metastatic rectal cancer who underwent either laparoscopic resection (LR, n = 93) or open resection (OR, n = 177) in an academic medical center...
December 1, 2021: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/34716474/mid-and-low-rectal-cancer-laparoscopic-vs-open-treatment-short-and-long-term-results-meta-analysis-of-randomized-controlled-trials
#14
REVIEW
Mario Schietroma, Lucia Romano, Adriana Ionelia Apostol, Silvia Vada, Stefano Necozione, Francesco Carlei, Antonio Giuliani
BACKGROUND: The laparoscopic approach in the treatment of mid- or low-rectal cancer is still controversial. Compared with open surgery, laparoscopic resection of extraperitoneal cancer is associated with improved short-time non-oncological outcomes, although high-level evidence showing similar short- and long-term oncological outcomes is scarce. OBJECTIVE: The aim of our paper is to study the oncological and non-oncological outcomes of laparoscopic versus open surgery for extraperitoneal rectal cancer...
January 2022: International Journal of Colorectal Disease
https://read.qxmd.com/read/34701977/the-evolving-landscape-of-treatment-paradigms-for-locally-advanced-rectal-cancer-a-survey-study-of-gastrointestinal-radiation-oncology-experts
#15
JOURNAL ARTICLE
T C Wu, N N Sanford, S Anand, J Y Wo, A Raldow
PURPOSE/OBJECTIVE(S): To assess current practice patterns in the treatment of locally advanced rectal cancer among radiation oncologists specializing in gastrointestinal (GI) malignancies. MATERIALS/METHODS: Radiation oncologists specialized in GI malignancies at an ACGME affiliated institution were invited to complete an online survey and select management recommendations for seven locally advanced rectal cancer clinical vignettes, consisting of variable T and N staging, tumor location and high-risk features (presence of enlarged lateral lymph nodes, mesorectal fascia involvement and extramural vascular invasion)...
November 1, 2021: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/34700399/multi-institutional-comparison-of-sc-tnt-and-lc-tnt-for-rectal-cancer-non-operative-management
#16
JOURNAL ARTICLE
M Moskalenko, H Kim, R I Chin, A Roy, S N Badiyan, P Bauer, K Fakhoury, L E Henke, W Herter, C Lieu, A M Moyer, M Mutch, P J Parikh, K Pedersen, T Schefter, M Silviera, G Srivastava, J D Vogel, B Chapman, J R Olsen
PURPOSE/OBJECTIVE(S): Recent data support the use of total neoadjuvant therapy (TNT) for treatment of locally advanced rectal cancer (LARC), although the optimal TNT regimen and therapy sequence is unclear for non-operative management (NOM). We performed a multi-institutional comparison of short-course radiation (SCRT) followed by consolidation chemotherapy (SC-TNT) versus long-course chemoradiation (CRT) preceded by induction chemotherapy (LC-TNT), after adoption of NOM at both institutions...
November 1, 2021: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/34686879/organ-preservation-following-short-course-radiotherapy-for-rectal-cancer
#17
JOURNAL ARTICLE
Per J Nilsson, Madelene Ahlberg, Shahrzad Kordnejad, Torbjörn Holm, Anna Martling
BACKGROUND: Non-operative management of rectal cancer is increasingly being used in selected patients. Most reports include patients treated with chemoradiotherapy (CRT) before inclusion into a Watch & Wait (W&W) programme. The aim of this study was to report outcomes from a single-centre W&W programme involving a large cohort of patients. METHODS: Patients treated with chemoradiotherapy (CRT) or short-course radiotherapy (SCRT) with or without chemotherapy, between 2008 and 2020, who showed signs of a clinical complete response (cCR) were reviewed...
September 6, 2021: BJS Open
https://read.qxmd.com/read/33844090/trans-anal-minimally-invasive-surgery-tamis-versus-trans-anal-endoscopic-microsurgery-tem-a-comparative-case-control-matched-pairs-analysis
#18
JOURNAL ARTICLE
Francesco Stipa, Simone Maria Tierno, Giulia Russo, Antonio Burza
AIM: Since its introduction, transanal endoscopic microsurgery (TEM) has become the treatment of choice for rectal benign lesions not amenable to flexible endoscopic excision and for early rectal cancer. Disposable soft devices as the Trans-anal Minimally Invasive Surgery (TAMIS) are a valid alternative to non-disposable rigid trans-anal endoscopic microsurgery (TEM) platforms. The aim of the present study is to compare TEM and TAMIS in terms of incidence of R1 resection and lesion fragmentation which were combined in a composite outcome called quality resection...
March 2022: Surgical Endoscopy
https://read.qxmd.com/read/33585353/short-and-mid-term-outcomes-of-transanal-versus-laparoscopic-total-mesorectal-excision-for-low-rectal-cancer-a-meta-analysis
#19
JOURNAL ARTICLE
Jingqing Ren, Huixing Luo, Shaojie Liu, Bailin Wang, Fan Wu
PURPOSE: The current meta-analysis combining mid and low rectal cancer with no meta-analysis only for low rectal cancer was seen. This meta-analysis was to compare the short- and mid-term outcomes of the transanal total mesorectal excision (TaTME) vs. laparoscopic total mesorectal excision (LaTME) for low rectal cancer. METHODS: A systematic literature search was conducted using the web-based databases; China National Knowledge Infrastructure, Chinese BioMedical Database, PubMed, Embase, Cochrane Central Register of Controlled Trials, and Wanfang Database...
February 2021: Annals of Surgical Treatment and Research
https://read.qxmd.com/read/33256819/analysis-of-long-term-oncological-results-of-clinical-versus-pathological-responses-after-neoadjuvant-treatment-in-locally-advanced-rectal-cancer
#20
JOURNAL ARTICLE
Mariana F Coraglio, Martin A Eleta, Mirta R Kujaruk, Javier H Oviedo, Enrique L Roca, Guillermo A Masciangioli, Guillermo Mendez, Ilma S Iseas
BACKGROUND: Nonoperative management after neoadjuvant treatment in low rectal cancer enables organ preservation and avoids surgical morbidity. Our aim is to compare oncological outcomes in patients with clinical complete response in watch and wait strategy with those who received neoadjuvant therapy followed by surgery with a pathological complete response. METHODS: Patients with non-metastatic rectal cancer after neoadjuvant treatment with clinical complete response in watch and wait approach (group 1, n = 26) and complete pathological responders (ypT0N0) after chemoradiotherapy and surgery (group 2, n = 22), between January 2011 and October 2018, were included retrospectively, and all of them evaluated and followed in a multidisciplinary team...
November 30, 2020: World Journal of Surgical Oncology
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