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radiofrequency ablation colorectal liver

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https://www.readbyqxmd.com/read/27931834/treatments-for-colorectal-liver-metastases-a-new-focus-on-a-familiar-concept
#1
REVIEW
M G Zampino, E Magni, P S Ravenda, C A Cella, G Bonomo, P Della Vigna, S Galdy, F Spada, G M Varano, G Mauri, N Fazio, F Orsi
A major challenge for the management of advanced-colorectal-cancer is the multidisciplinary approach required for the treatment of liver metastases. Reducing the burden of liver metastases with liver-directed therapy has an important impact on both survival and health-related quality of life. This paper debates the rationale and current liver-directed approaches for colorectal liver metastases based on the evidence of literature and new clinical trials. Surgery is the gold standard, when feasible, and it's the main treatment goal for patients with potentially-resectable disease as a means of prolonging progression-free survival...
December 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27928604/-surgery-of-colorectal-lung-metastases-results-of-a-survey-in-germany
#2
W Dudek, W Schreiner, P Stapel, N Vassos, R Grützmann, H Sirbu
BACKGROUND: There is no evidence from randomized trials on the prognostic significance of pulmonary metastasectomy of colorectal cancer. The objective of this study was to assess the current criteria for indications, preoperative diagnostics and preferred operative techniques of pulmonary metastasectomy in Germany. METHODS: An anonymous survey was carried out in 239 German centers performing thoracic surgery in October 2015. RESULTS: Chest computed tomography (CT, 98%), liver CT (62%), pelvis CT (39%) and fluorodeoxyglucose positron emission tomography (FDG-PET, 37%) were used by the respondents (65% of participants) for preoperative staging...
December 7, 2016: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/27928458/anatomical-hepatectomy-for-liver-metastasis-from-rectal-adenocarcinoma-presenting-with-intrabiliary-extension-a-case-report
#3
Tetsuo Kon, Hideo Suzuki, Tatsuya Kawaguchi, Kazuyuki Gyoten, Hideki Machishi, Takashi Kurumiya, Yoshikatsu Okada
Liver metastases from colorectal carcinoma commonly form nodular lesions in the liver parenchyma. We report a case of liver metastasis from rectal adenocarcinoma that extended predominantly into the bile duct. A 62-year-old Japanese man underwent low anterior resection for rectal adenocarcinoma 9 years ago. Approximately 3 years later, he underwent radiofrequency ablation therapy for a metastatic liver tumor. Nine years after surgery, a tumor in liver segment III exhibiting intrabiliary extension was discovered; it was unclear if this was a metastatic liver tumor or intrahepatic cholangiocarcinoma...
2016: Journal of Rural Medicine: JRM
https://www.readbyqxmd.com/read/27916360/combined-resection-and-rfa-in-colorectal-liver-metastases-stratification-of-long-term-outcomes
#4
Kazunari Sasaki, Georgios A Margonis, Nikolaos Andreatos, Yuhree Kim, Ana Wilson, Faiz Gani, Neda Amini, Timothy M Pawlik
BACKGROUND: Combined hepatic resection and radiofrequency ablation (resection-RFA) is a widely accepted multidisciplinary treatment for unresectable colorectal cancer liver metastases. Worse prognosis after resection-RFA is correlated to tumor morphology, although unfavorable morphology is inherent to this patient cohort. This study aimed to select patients who may or may not benefit from resection-RFA with the aid of tumor biology. METHOD: Data from 485 patients who underwent curative hepatectomy with or without concurrent RFA were retrospectively collected and analyzed...
November 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27877209/impact-of-systemic-therapy-and-recurrence-pattern-on-survival-outcome-after-radiofrequency-ablation-for-colorectal-liver-metastases
#5
Axel Stang, Marcello Donati, Hauke Weilert, Karl Jürgen Oldhafer
Background: Most patients undergoing radiofrequency ablation (RFA) of colorectal liver metastasases (CLM) develop disease recurrence, but little is known about the effect of recurrence patterns and/or systemic therapy on outcome. In this study, we examined the recurrence patterns and survival after systemic therapy plus RFA in patients with unresectable CLM without extrahepatic disease. The aims were to analyze the effect of recurrence patterns on survival and to assess the relative benefit contributed by systemic therapy and local ablation to disease control and patient outcome...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27870679/new-developments-in-interventional-oncology-liver-metastases-from-colorectal-cancer
#6
Joseph R Kallini, Ahmed Gabr, Nadine Abouchaleh, Rehan Ali, Ahsun Riaz, Robert J Lewandowski, Riad Salem
Colorectal cancer is the third leading cause of cancer death in the United States. Although hepatic excision is the first-line treatment for colorectal liver metastasis (CRLM), few patients are candidates. Locoregional therapy (LRT) encompasses minimally invasive techniques practiced by interventional radiology. These include ablative treatments (radiofrequency ablation, microwave ablation, and cryosurgical ablation) and transcatheter intra-arterial therapy (hepatic arterial infusion chemotherapy, transarterial "bland" embolization, transarterial chemoembolization, and radioembolization with yttrium 90)...
November 2016: Cancer Journal
https://www.readbyqxmd.com/read/27855365/phase-ii-iii-study-of-radiofrequency-ablation-combined-with-cytokine-induced-killer-cells-treating-colorectal-liver-metastases
#7
Xiaodong Li, Xichao Dai, Liangrong Shi, Yong Jiang, Xuemin Chen, Lujun Chen, Jiemin Zhao, Weiguang Qiang, Jun Wu, Mei Ji, Jingting Jiang, Changping Wu
PURPOSE: This phase II/III, non-randomized clinical trial aimed to determine the efficacy and safety of the combination of radiofrequency ablation (RFA) and cytokine-induced killer (CIK) cells transfusion for patients with colorectal liver metastases (CRLMs). EXPERIMENTAL DESIGN: A total of 60 eligible patients with CRLMs were enrolled and divided into Group A (RFA alone, n = 30) and Group B (RFA plus CIK, n = 30), and following enzyme-linked immunosorbent spot assay was performed in 8 patients with CEA > 50 ng/mL pre-RFA and 7 days post-RFA and CIK treatment, respectively...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27780345/radiofrequency-in-the-management-of-colorectal-liver-metastases-a-10-year-experience-at-a-single-center
#8
Sandra Aissou, Victoire Cartier, Antoine Hamy, Fleur Plumereau, Christophe Aube, Emilie Lermite
BACKGROUND: Liver resection is the curative treatment for patients with colorectal liver metastases (CRLMs), with five-year survival rates of 30-50%. Radiofrequency ablation (RFA) is a local and useful alternative for patients with non-resectable CRLMs to obtain complete tumor clearance. The aim of this study was to analyze survival rates with this local treatment. MATERIALS AND METHODS: All patients who underwent RFA and resection or RFA alone for unresectable CRLMs between 2001 and 2012 were included in a retrospective study...
October 26, 2016: Surgical Technology International
https://www.readbyqxmd.com/read/27750238/us-us-fusion-imaging-in-radiofrequency-ablation-for-liver-metastases
#9
Yasunori Minami, Tomohiro Minami, Hirokazu Chishina, Masashi Kono, Tadaaki Arizumi, Masahiro Takita, Norihisa Yada, Satoru Hagiwara, Hiroshi Ida, Kazuomi Ueshima, Naoshi Nishida, Masatoshi Kudo
OBJECTIVE: Radiofrequency ablation (RFA) induces gas bubbles in ablation zones, and the ablative margin cannot be evaluated accurately on ultrasound (US) during and immediately after RFA. This study assessed the usefulness of US-US fusion imaging to visualize the ablative margin of RFA for liver metastasis. METHODS: RFA guided by US-US fusion imaging was performed on 12 targeted tumors in 10 patients. Secondary hepatic malignancies included patients with colorectal cancer (n = 4), breast cancer (n = 2), lung cancer (n = 1), gastrointestinal stromal tumor (n = 1), pancreatic neuroendocrine tumor (n = 1), and adrenocortical carcinoma (n = 1)...
2016: Digestive Diseases
https://www.readbyqxmd.com/read/27705879/local-tumor-progression-patterns-after-radiofrequency-ablation-of-colorectal-cancer-liver-metastases
#10
Marc Napoleone, Ania Z Kielar, Rebecca Hibbert, Sameh Saif, Benjamin Y Kwan
PURPOSE: We aimed to evaluate patterns of local tumor progression (LTP) after radiofrequency ablation (RF ablation) of colorectal cancer liver metastases (CRCLM) and to highlight the percentage of LTP not attributable to lesion size or RF ablation procedure-related factors (heat sink or insufficient ablation margin). METHODS: CRCLM treated by RF ablation at a single tertiary care center from 2004-2012, with a minimum of six months of postprocedure follow-up, were included in this retrospective study...
November 2016: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/27684857/the-role-of-radiofrequency-ablation-for-treatment-of-metachronous-isolated-hepatic-metastasis-from-colorectal-cancer
#11
Byoung Chul Lee, Hyun Gu Lee, In Ja Park, So Yeon Kim, Ki-Hun Kim, Jae Hoon Lee, Chan Wook Kim, Jong Lyul Lee, Yong Sik Yoon, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
We investigated recurrence pattern and oncologic outcomes after treatment of metachronous isolated liver metastases from colorectal cancer according to treatment modality.We retrospectively analyzed 123 patients treated with hepatic resection and 82 patients treated with radiofrequency ablation (RFA) for metachronous isolated hepatic metastasis from colorectal cancer (HMCRC). We compared clinicopathological data, recurrence pattern, and recurrence-free survival (RFS) rates after the treatment of hepatic metastasis between patients treated with RFA and resection...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27646023/surgical-treatment-of-colorectal-cancer-with-peritoneal-and-liver-metastases-using-combined-liver-and-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-report-from-a-single-centre-experience
#12
Julie Navez, Christophe Remue, Daniel Leonard, Radu Bachmann, Alex Kartheuser, Catherine Hubert, Laurent Coubeau, Mina Komuta, Marc Van den Eynde, Francis Zech, Nicolas Jabbour
BACKGROUND: Chemotherapeutic advances have enabled successful cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) expansion in treating metastatic colorectal cancer. OBJECTIVES: The aims of this study were to evaluate the safety of combining liver surgery (LS) with HIPEC and CRS (which remains controversial) and its impact on overall survival (OS) rates. METHODS: From 2007 to 2015, a total of 77 patients underwent CRS/HIPEC for peritoneal carcinomatosis (PC) of colorectal cancer...
September 19, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27593593/longterm-survival-outcomes-of-patients-undergoing-treatment-with-radiofrequency-ablation-for-hepatocellular-carcinoma-and-metastatic-colorectal-cancer-liver-tumors
#13
Iswanto Sucandy, Susannah Cheek, Benjamin J Golas, Allan Tsung, David A Geller, James W Marsh
BACKGROUND: We aim to investigate long-term survival outcomes in patients undergoing radiofrequency ablation (RFA), based on our longitudinal 5 and 10 year follow-up data. METHODS: All patients who underwent RFA for hepatocellular carcinoma (HCC) and colorectal liver metastasis (CLM) between 1999 and 2010. RESULTS: 320 patients were included with oncologic diagnoses of HCC in 122 (38.1%) and CLM in 198 (61.9%). The majority of patients had a single tumor ablation (71% RFA 1 lesion)...
September 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27490681/two-cases-of-laparoscopic-simultaneous-resection-of-colorectal-cancer-and-synchronous-liver-metastases-in-elderly-patients
#14
Tomoaki Ito, Tomoyuki Kushida, Mutsumi Sakurada, Hiroshi Maekawa, Hajime Orita, Konomi Mizuguchi, Koichi Sato
INTRODUCTION: The laparoscopic resection of colorectal cancer and laparoscopic liver surgery are widely considered to be safe. Recently, it has been reported that the simultaneous laparoscopic resection of primary colorectal cancer and liver metastasis is technically feasible and safe when it is performed at experienced centers. However, the feasibility of simultaneous laparoscopic procedures for colorectal cancer and synchronous colorectal liver metastases in elderly patients has not been studied sufficiently...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27465325/radiofrequency-ablation-vs-hepatic-resection-for-resectable-colorectal-liver-metastases
#15
Nan He, Qian-Na Jin, Di Wang, Yi-Ming Yang, Yu-Lin Liu, Guo-Bin Wang, Kai-Xiong Tao
The treatments of resectable colorectal liver metastases (CRLM) are controversial. This study aimed to evaluate the relative efficacy and safety of hepatic resection (HR) and radiofrequency ablation (RFA) for treating resectable CRLM. Between January 2004 and May 2010, the enrolled patients were given hepatic resection (HR group; n=32) or percutaneous RFA (RFA group; n=21) as a first-line treatment for CRLM. All the tumors had a maximum diameter of 3.5 cm and all patients had five or less tumors. The patient background, tumor characteristics, cumulative survival rate and recurrence-free survival rate were assessed in both groups...
August 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/27444839/a-comparison-of-perioperative-outcomes-in-elderly-patients-with-malignant-liver-tumors-undergoing-laparoscopic-liver-resection-versus-radiofrequency-ablation
#16
Pinar Yazici, Muhammet Akyuz, Hakan Yigitbas, Cem Dural, Alexis Okoh, Nail Aydin, Eren Berber
BACKGROUND: Liver resection is the treatment option with the best chance for cure in patients with malignant liver tumors. However, there are concerns regarding postoperative recovery in elderly patients, which may lead to a preference of non-resectional therapies over hepatectomy in this patient population. Although laparoscopic liver resection (LLR) is associated with a faster recovery compared to open hepatectomy, there are scant data on how elderly patients tolerate LLR. The aim of this study was to analyze the perioperative outcomes of LLR in elderly patients with hepatic malignancies, with a comparison to laparoscopic RFA (LRFA)...
July 21, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27444829/precoagulation-assisted-parenchyma-sparing-laparoscopic-liver-surgery-rationale-and-surgical-technique
#17
Elisa Francone, Elena Muzio, Luigi D'Ambra, Carlo Aschele, Teseo Stefanini, Cinzia Sani, Emilio Falco, Stefano Berti
BACKGROUND: For the treatment of both primary and metastatic liver tumors, laparoscopic parenchyma-sparing surgery is advocated to reduce postoperative liver failure and facilitate reoperation in the case of recurrence. However, atypical and wedge resections are associated with a higher amount of intraoperative bleeding than are anatomical resections, and such bleeding is known to affect short- and long-term outcomes. Beyond the established role of radiofrequency and microwave ablation in the setting of inoperable liver tumors, the application of thermoablative energy along the plane of the liver surface to be transected results in a zone of coagulative necrosis, possibly minimizing bleeding of the cut liver surface during parenchymal transection...
July 21, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27396228/the-outcome-of-radiofrequency-ablation-of-metastatic-liver-tumors
#18
Somrach Thamtorawat, Satit Rojwatcharapibarn, Trongtum Tongdee, Thanongchai Siriapisith
OBJECTIVE: To determine outcome of radiofrequency ablation (RFA) in metastatic liver tumor and to evaluate related factors of residual or local tumor recurrences. MATERIAL AND METHOD: With Institutional Review Board approval, we retrospectively reviewed RFA procedure between June 2006 and September 2013. Fifty-seven metastatic nodules in 36 patients were treated. The primary tumors were colorectal carcinoma (n = 30), neuroendocrine tumor (n = 2), gallbladder carcinoma (n = 1), adenocarcinoma of head of pancreas (n = 1), and gastrointestinal stromal tumor (n = 2)...
April 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
https://www.readbyqxmd.com/read/27387188/mwa-versus-rfa-for-perivascular-and-peribiliary-crlm-a-retrospective-patient-and-lesion-based-analysis-of-two-historical-cohorts
#19
Aukje A J M van Tilborg, Hester J Scheffer, Marcus C de Jong, Laurien G P H Vroomen, Karin Nielsen, Cornelis van Kuijk, Petrousjka M P van den Tol, Martijn R Meijerink
PURPOSE: To retrospectively analyse the safety and efficacy of radiofrequency ablation (RFA) versus microwave ablation (MWA) in the treatment of unresectable colorectal liver metastases (CRLM) in proximity to large vessels and/or major bile ducts. METHOD AND MATERIALS: A database search was performed to include patients with unresectable histologically proven and/or (18)F-FDG-PET avid CRLM who were treated with RFA or MWA between January 2001 and September 2014 in a single centre...
October 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27244540/codon-13-kras-mutation-predicts-patterns-of-recurrence-in-patients-undergoing-hepatectomy-for-colorectal-liver-metastases
#20
Georgios A Margonis, Yuhree Kim, Kazunari Sasaki, Mario Samaha, Neda Amini, Timothy M Pawlik
BACKGROUND: Investigations regarding the impact of tumor biology after surgical management of colorectal liver metastasis have focused largely on overall survival. We investigated the impact of codon-specific KRAS mutations on the rates and patterns of recurrence in patients after surgery for colorectal liver metastasis (CRLM). METHODS: All patients who underwent curative-intent surgery for CRLM between 2002 and 2015 at Johns Hopkins who had available data on KRAS mutation status were identified...
September 1, 2016: Cancer
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