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radiofrequency ablation colorectal liver

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https://www.readbyqxmd.com/read/28643305/-interventional-therapy-of-colorectal-liver-metastasis
#1
Qi Zhang, Gaojun Teng
Colorectal liver metastasis (CRLM) is one of the most difficult and key points in the treatment of colorectal cancer. Approximately 50% to 60% of patients diagnosed as colorectal cancer develops metastasis, and 80% to 90% of CRLM is unresectable. Surgical resection is the first-line treatment for CRLM, while it is only suitable for about 15% patients. Systemic chemotherapy can prolong the survival of CRLM patients, however, a part of CRLM patients are resistant to chemotherapy. With the development of technology and the update of clinical evidence, individual therapy with target drugs and multidisciplinary treatment (MDT) have became a tendency, and minimally invasive interventional therapy has gained more acceptance in the MDT mode of the treatment for CRLM...
June 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28636427/liver-directed-therapy-in-metastatic-colorectal-cancer
#2
Ciara M Kelly, Nancy E Kemeny
Colorectal cancer is a significant global health issue with over 1 million cases diagnosed annually throughout the world. 15% of patients diagnosed with colorectal cancer will have liver metastases and 60% will develop liver metastases if they have metastatic disease. Oligometastatic colorectal cancer confined to the liver represents an intermediate state in the evolution of metastatic capacity that opens the opportunity for local interventions. Area's covered: The literature supports long-term survival if patients undergo liver resection of colorectal metastases...
June 21, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28628012/curative-treatment-of-colorectal-cancer-solitary-metastasis-to-liver-subcapsule-by-percutaneous-us-guided-radiofrequency-ablation-using-hydrodissection-case-report
#3
N Paksashvili, T Ninikashvili, T Azrumelashvili, M Mizandari
Case report presents the successful treatment of solitary liver metastasis in a patient with resected colon cancer. A 39-year-old male underwent left hemicolectomy with colostomy formation followed by chemotherapy for a moderately differentiated adenocarcinoma of the colon. Two years later, a liver metastatic lesion was detected. Patient received chemotherapy; the mass remained stable in size, measuring up to 3 cm in diameter. Low-invasive percutaneous curative treatment by Radiofrequency ablation was conducted using hydrodissection by dielectric fluid intraperitoneal introduction for hydrodissection...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28612019/thermal-ablation-in-the-management-of-colorectal-cancer-patients-with-oligometastatic-liver-disease
#4
REVIEW
Elena Nadia Petre, Constantinos Sofocleous
BACKGROUND: Surgical resection of limited colorectal liver disease improves long-term survival and can be curative in a subset of selected cases. Image-guided percutaneous ablation therapies have emerged as safe and effective alternative options for selected patients with unresectable colorectal liver metastases (CLM) that can be ablated with margins. Ablation causes focal destruction of tissue and has increasingly been shown to provide durable eradication of tumors. METHODS: A selective review of literature was conducted in PubMed, focusing on recent studies reporting on the safety, efficacy, and long-term outcomes of percutaneous ablation modalities in the treatment of CLM...
March 2017: Visceral Medicine
https://www.readbyqxmd.com/read/28490983/institutional-experience-in-the-treatment-of-colorectal-liver-metastases-with-stereotactic-body-radiation-therapy
#5
Alejandra Méndez Romero, Fatma Keskin-Cambay, Rob M van Os, Joost J Nuyttens, Ben J M Heijmen, Jan N M IJzermans, Cornelis Verhoef
AIM: To investigate whether the impact of dose escalation in our patient population represented an improvement in local control without increasing treatment related toxicity. MATERIALS AND METHODS: A cohort of consecutive patients with colorectal liver metastases treated with stereotactic body radiation therapy (SBRT) between December 2002 and December 2013 were eligible for this study. Inclusion criteria were a Karnofsky performance status ≥80% and, according to the multidisciplinary tumor board, ineligibility for surgery or radiofrequency ablation...
March 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28376151/local-treatment-of-unresectable-colorectal-liver-metastases-results-of-a-randomized-phase-ii-trial
#6
RANDOMIZED CONTROLLED TRIAL
Theo Ruers, Frits Van Coevorden, Cornelis J A Punt, Jean-Pierre E N Pierie, Inne Borel-Rinkes, Jonathan A Ledermann, Graeme Poston, Wolf Bechstein, Marie-Ange Lentz, Murielle Mauer, Gunnar Folprecht, Eric Van Cutsem, Michel Ducreux, Bernard Nordlinger
Background: Tumor ablation is often employed for unresectable colorectal liver metastases. However, no survival benefit has ever been demonstrated in prospective randomized studies. Here, we investigate the long-term benefits of such an aggressive approach. Methods: In this randomized phase II trial, 119 patients with unresectable colorectal liver metastases (n < 10 and no extrahepatic disease) received systemic treatment alone or systemic treatment plus aggressive local treatment by radiofrequency ablation ± resection...
September 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28373752/prognostic-factors-for-transarterial-chemoembolization-combined-with-sustained-oxaliplatin-based-hepatic-arterial-infusion-chemotherapy-of-colorectal-cancer-liver-metastasis
#7
Hangyu Zhang, Jianhai Guo, Song Gao, Pengjun Zhang, Hui Chen, Xiaodong Wang, Xiaoting Li, Xu Zhu
OBJECTIVE: To investigate the prognostic factors in chemorefractory colorectal cancer liver metastasis (CRCLM) patients treated by transarterial chemoembolization (TACE) and sustained hepatic arterial infusion chemotherapy (HAIC). METHODS: Between 2006 and 2015, 162 patients who underwent 763 TACE and HAIC in total were enrolled in this retrospective study, including 110 males and 52 females, with a median age of 60 (range, 26-83) years. Prognostic factors were assessed with Log-rank test, Cox univariate and multivariate analyses...
February 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28355754/-colorectal-resection-combined-with-simultaneous-radiofrequency-ablation-in-the-treatment-of-synchronous-colorectal-liver-metastases-a-retrospective-analysis
#8
Y L Guo, Z H Tong, X Xu, Y Zhao, J W Liu, H G Wang, G L Dong
Objective: To compare the efficacy and safety of colorectal resection combined with simultaneous radiofrequency ablation (RFA) in the treatment of synchronous colorectal liver metastases(SCRLM). Methods: This retrospective study involved the patients admitted between January 1st 2010 and September 1st 2013. A total of 20 patients who underwent colorectal resection combined with simultaneous RFA of SCRLM were enrolled. Those patients (RFA group) were matched with 20 patients (Resection group) who underwent simultaneous resections of colorectal cancer and SCRLM based on the propensity scores...
March 28, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28240755/mechanical-thrombolysis-as-an-adjunct-therapy-to-management-of-portal-vein-thrombosis-following-radio-frequency-ablation
#9
A O Hairol, C A Affirul, A Azlanudin, Z Zamri, J Razman, S Y Choi
Radiofrequency ablation (RFA) has evolved to become the treatment of choice for non-resectable recurrent colorectal liver metastasis. It is however, not without complications. Portal vein thrombosis following RFA is rare but can be fatal to the outcome of the patient. Here, we present a case of a 66-year-old man who developed portal vein thrombosis following RFA. CT scan revealed a left portal vein thrombosis. This case report highlights the challenges and multimodal treatment of portal vein thrombosis following Radiofrequency ablation (RFA) in a cirrhotic patient...
January 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28237869/the-role-of-image-guided-therapy-in-the-management-of-colorectal-cancer-metastatic-disease
#10
REVIEW
Thierry de Baere, Lambros Tselikas, Steven Yevich, Valérie Boige, Frederic Deschamps, Michel Ducreux, Diane Goere, France Nguyen, David Malka
The European Society for Medical Oncology (ESMO) have stressed that the option for treating oligometastatic disease is a strategy of local ablative therapy, the goal of which is to improve disease control. The spectrum of the local ablative therapy toolbox described by the ESMO includes surgical R0 resection, percutaneous ablation and intra-arterial therapies, the choice of treatment being left to the multidisciplinary team. Interventional therapy involving image-guided treatment offers the possibility of less invasive treatments for colorectal cancer metastases in the liver, lung and bone by preserving from toxicity distant healthy organs or even parts of the diseased organs...
February 23, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28145969/a-new-technique-of-radiofrequency-assisted-ultrasound-guided-needle-localized-laparoscopic-resection-of-disappearing-colorectal-liver-metastases
#11
Hakan Yigitbas, Pinar Yazici, Halit E Taskin, Alexis K Okoh, Cem Dural, Nail Aydin, Eren Berber
The management of disappearing colorectal liver metastases in the postadjuvant chemotherapy setting is challenging. We describe a novel technique that facilitates laparoscopic resection of disappearing metastatic liver lesions with great precision. Details of this new technique are described in 2 patients with colorectal cancer synchronously metastatic to the liver. Both patients had small indistinct intraparenchymal liver lesions after adjuvant chemotherapy. A video displays the steps of the procedure. Both patients presented with colorectal cancer with synchronous liver metastasis...
February 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28133019/-radiofrequency-ablation-combined-with-hepatectomy-for-the-treatment-of-liver-metastases-from-colorectal-cancer
#12
Masanobu Enomoto, Tomoya Tago, Kenta Kasahara, Takahiro Wada, Takaaki Matsudo, Yusuke Murakoshi, Tetsuo Ishizaki, Kazuhiko Kasuya, Kenji Katsumata, Akihiko Tsuchida
OBJECTIVE: We evaluated hepatectomy combined with radiofrequency ablation(RFA)in patients with liver metastases from colorectal cancer for which curative resection is difficult. METHODS: This study included 13 patients who underwent hepatectomy combined with RFA for liver metastases from colorectal cancer in or before 2015. RESULTS: In 11 patients who were determined to have achieved a complete curative resection, the 50%survival time was 35...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28130578/-liver-metastases-of-colorectal-cancer
#13
R-T Hoffmann
Liver metastases are the most common cause of death in colorectal cancer patients. Nowadays, complete resection is considered to be the only curative treatment but only approximately 25% of patients are suitable candidates for surgery; therefore, many different interventional oncology techniques have been developed in recent years for the treatment of secondary liver metastases. The aim of interventional oncological procedures is either to provide a potentially curative treatment option for locally limited metastases with local ablative techniques, to enable nonresectable tumors to become accessible to surgical or local ablative techniques using transarterial procedures or to achieve improved survival in a palliative setting...
February 2017: Der Radiologe
https://www.readbyqxmd.com/read/28112813/long-term-outcomes-of-radiofrequency-ablation-combined-with-hepatectomy-compared-with-hepatectomy-alone-for-colorectal-liver-metastases
#14
K Imai, M-A Allard, C Castro Benitez, E Vibert, A Sa Cunha, D Cherqui, D Castaing, H Baba, R Adam
BACKGROUND: Combining radiofrequency ablation (RFA) with hepatectomy may enable treatment with curative intent for patients with colorectal liver metastasis (CRLM). However, the oncological outcomes in comparison with resection alone remain to be clarified. METHODS: Patients who underwent a first hepatectomy between 2001 and 2012 for CRLM were enrolled. Short- and long-term outcomes of patients who underwent hepatectomy plus RFA were compared with those of patients who had hepatectomy alone using propensity score matching...
April 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28109674/single-center-nonrandomized-clinical-trial-to-assess-the-safety-and-efficacy-of-irreversible-electroporation-ire-ablation-of-liver-tumors-in-humans-short-to-mid-term-results
#15
P Frühling, A Nilsson, F Duraj, U Haglund, A Norén
INTRODUCTION: A single-center nonrandomized clinical trial was performed to assess the safety and efficacy of IRE ablation of liver tumors in humans. METHODS: 38 malignant liver tumors on 30 patients were treated with IRE between September 2011 and September 2014. Treatment was with curative intent, and the diagnoses were colorectal cancer with liver metastases (CRLM) (n = 23), hepatocellular carcinoma (HCC) (n = 8) and other metastasis (n = 7). Patients were selected when surgery, radiofrequency ablation (RFA) or microwave ablation (MWA) was not an option, and when they met inclusion criteria (tumor size < 3 cm, 1-2 tumors)...
April 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28054139/-local-ablative-radiotherapy-of-oligometastatic-colorectal-cancer
#16
C Petersen, T Gauer
BACKGROUND: Colorectal cancer (CRC) often presents as oligometastatic disease. Currently available intensive systemic treatment regimens, including combination chemotherapy and molecular targeted agents, result in tumor response and transient to long-term disease control in a high percentage of patients, thus raising the question of further management. Secondary resection and ablation, e.g. by surgery or radiofrequency may contribute to long-term survival and even be curative or at least allow a relevant chemotherapy-free interval...
February 2017: Der Radiologe
https://www.readbyqxmd.com/read/27999917/radiofrequency-ablation-combined-with-hepatic-arterial-chemoembolization-using-degradable-starch-microsphere-mixed-with-mitomycin-c-for-the-treatment-of-liver-metastasis-from-colorectal-cancer-a-prospective-multicenter-study
#17
MULTICENTER STUDY
Koichiro Yamakado, Yasutaka Inaba, Yozo Sato, Taku Yasumoto, Sadao Hayashi, Takashi Yamanaka, Koji Nobata, Haruyuki Takaki, Atsuhiro Nakatsuka
PURPOSE: This phase II prospective study investigates possible benefits of radiofrequency ablation (RFA) combined with hepatic arterial chemoembolization using degradable starch microsphere (DSM) mixed with mitomycin C (MMC) in non-surgical candidates with colorectal liver metastases. MATERIALS AND METHODS: This study, approved by the respective institutional review board, included non-surgical candidates with 3 or fewer liver tumors of 3 cm or smaller, or a single lesion 5 cm or smaller...
April 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27995093/new-perspectives-in-the-treatment-of-colorectal-metastases
#18
REVIEW
Dominique Elias, Luca Viganò, Franco Orsi, Marta Scorsetti, Tiziana Comito, Jan Lerut, Davide Cosola, Guido Torzilli
BACKGROUND: In recent years, the management of metastatic colorectal cancer has become more aggressive and more multidisciplinary. New treatment options have been proposed in addition to the standard approach of resection of liver metastases and chemotherapy. SUMMARY: Selected patients with synchronous limited peritoneal and liver disease (peritoneal cancer index <12 and <3 liver metastases) can be scheduled for aggressive treatment, including cytoreductive surgery, hyperthermic intraperitoneal chemotherapy, and liver resection...
November 2016: Liver Cancer
https://www.readbyqxmd.com/read/27979717/perioperative-triplet-chemotherapy-and-cetuximab-in-patients-with-ras-wild-type-high-recurrence-risk-or-borderline-resectable-colorectal-cancer-liver-metastases
#19
Filippo Pietrantonio, Maria Di Bartolomeo, Christian Cotsoglou, Alessia Mennitto, Rosa Berenato, Federica Morano, Jorgelina Coppa, Federica Perrone, Roberto Iacovelli, Massimo Milione, Alessandra Alessi, Marta Vaiani, Ilaria Bossi, Francesca Ricchini, Mauro Scotti, Marta Caporale, Emilio Bajetta, Filippo de Braud, Vincenzo Mazzaferro
BACKGROUND: For borderline resectable colorectal cancer liver metastases (CLM), systemic treatment can help to achieve R0 resection and reduce the risk of relapse. We assessed the role of perioperative triplet chemotherapy in combination with cetuximab in patients with RAS wild type high recurrence risk and/or borderline resectable CLM. PATIENTS AND METHODS: This was a monocenter, open-label phase II study. Borderline resectability was defined technically as tumor involvement of >1 hepatic vein, or >4 hepatic segments, need for 2-stage hepatectomy or radiofrequency ablation, and/or biologically (high risk): ≥4 metastatic nodules, or synchronous metastases...
October 6, 2016: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/27958231/radiofrequency-ablation-versus-liver-resection-for-colorectal-cancer-liver-metastasis-an-updated-systematic-review-and-meta-analysis
#20
REVIEW
Yue Han, Dong Yan, Fei Xu, Xiao Li, Jian-Qiang Cai
BACKGROUND: Controversial results about the therapeutic value of radiofrequency ablation (RFA) and liver resection (LR) in the treatment of colorectal cancer liver metastasis (CRCLM) have been reported. Thus, we performed the present meta-analysis to summarize the related clinical evidences. METHODS: A systematic literature search was conducted using PubMed (Medline), EMBASE, Cochrane Library, and Web of Science, for all years up to April 2016. Pooled analyses of the overall survival (OS), progression-free survival (PFS), and morbidity rates were performed...
December 20, 2016: Chinese Medical Journal
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