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sarcopenia in elder

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https://www.readbyqxmd.com/read/28633440/low-alanine-aminotransferase-levels-in-the-elderly-frailty-disability-sarcopenia-and-reduced-survival
#1
Umberto Vespasiani-Gentilucci, Antonio De Vincentis, Luigi Ferrucci, Stefania Bandinelli, Raffaele Antonelli Incalzi, Antonio Picardi
Background: Although low alanine aminotransferase (ALT) levels have been associated with poor outcomes in the elderly, the determinants subtending this association have been poorly explored. To gain insight into this topic, we analyzed data from a prospective population-based database (InCHIANTI study) in which frailty, disability, sarcopenia and pyridoxine levels were systematically assessed. Methods: Data are from 765 participants aged >65 years (mean age 75...
June 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28629717/sarcopenia-screened-by-the-sarc-f-questionnaire-and-physical-performances-of-elderly-women-a-cross-sectional-study
#2
Yves Rolland, Charlotte Dupuy, Gabor Abellan Van Kan, Matteo Cesari, Bruno Vellas, Marie Faruch, Cedric Dray, Philipe de Souto Barreto
OBJECTIVES: Screening for sarcopenia in daily practice can be challenging. Our objective was to explore whether the SARC-F questionnaire is a valid screening tool for sarcopenia (defined by the Foundation for the National Institutes of Health [FNIH] criteria). Moreover, we evaluated the physical performance of older women according to the SARC-F questionnaire. DESIGN: Cross-sectional study. PARTICIPANTS: Data from the Toulouse and Lyon EPIDémiologie de l'OStéoporose study (EPIDOS) on 3025 women living in the community (mean age: 80...
June 16, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28614835/aging-of-competitive-athletes
#3
Hirofumi Tanaka
Demographics of human aging are rapidly changing. As illustrated in the biomedicalization of aging, an ever increasing number of older adults is affected by a variety of clinical conditions and diseases, including vascular stiffening, sarcopenia, physical disability, and poor quality of life. One population that is situated in the opposite end of the health and functional spectrum to the sedentary frail elderly is Masters athletes. These older competitive athletes are endowed with substantial functional capacity, overall long-term health, high motivation, and psychosocial outlook...
June 15, 2017: Gerontology
https://www.readbyqxmd.com/read/28606408/-common-therapeutic-approaches-of-sarcopenia-in-the-elderly-and-uremic-myopathy
#4
Philippe Chauveau, Karine Moreau, Catherine Lasseur, Christian Combe, Michel Aparicio
The gradual loss of weight and function of muscle in patients with chronic kidney disease as in the elderly impacts the quality of life. Early management should help slow the functional limitation. Physical activity is the first therapy to propose that ensures stability of muscle mass and improved function. Resistance training programs have proven effective but are not yet widely available in nephrology units. The nutritional management should not be forgotten because there is a resistance to anabolism and protein intake should be involved in physical activity program...
June 9, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/28601218/-edmonton-frail-scale-in-colombian-older-people-comparison-with-the-fried-criteria
#5
Jairo Uriel Ramírez Ramírez, Miguel Oswaldo Cadena Sanabria, Miguel Enrique Ochoa
INTRODUCTION: The Edmonton Frailty Scale was developed in Alberta (Canada). It has been applied in different scenarios, such as acute units, day hospitals, and outpatient care. There are no studies published describing the usefulness of this scale in Colombia. MATERIALS AND METHODS: A cross-sectional study and secondary diagnostic test analysis was designed with the objective of studying the criterion validity of the Edmonton Frail Scale using Fried's frailty criteria as standard...
June 7, 2017: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/28591061/effects-of-elastic-resistance-exercise-on-body-composition-and-physical-capacity-in-older-women-with-sarcopenic-obesity-a-consort-compliant-prospective-randomized-controlled-trial
#6
Chun-De Liao, Jau-Yih Tsauo, Li-Fong Lin, Shih-Wei Huang, Jan-Wen Ku, Lin-Chuan Chou, Tsan-Hon Liou
BACKGROUND: Sarcopenia is associated with loss of muscle mass and an increased risk of physical disability in elderly people. However, the prevalence of sarcopenia has increased in obese elderly populations. The purpose of this study was to identify the clinical efficacy of elastic resistance exercise training (RET) in patients with sarcopenic obesity. METHODS: This study was conducted at the rehabilitation center of a university-based teaching hospital and was designed as a prospective and randomized controlled trial with an intention-to-treat analysis...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28572890/association-of-coffee-consumption-with-sarcopenia-in-korean-elderly-men-analysis-using-the-korea-national-health-and-nutrition-examination-survey-2008-2011
#7
Hyewon Chung, Ji Hyun Moon, Ju Il Kim, Mi Hee Kong, Jung Sik Huh, Hyeon Ju Kim
BACKGROUND: Sarcopenia is an age-related loss of muscle mass and strength. Coffee has antioxidant and anti-inflammatory properties that have been shown to be inversely related to the mechanism of sarcopenia. While there have been some studies on the effect of coffee on sarcopenia in animals, studies on the topic in humans are rare. Therefore, we investigated this relationship in elderly Korean men. METHODS: The cross-sectional data were derived from the 2008-2011 Korea National Health and Nutrition Examination Survey...
May 2017: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/28558678/high-prevalence-of-sarcopenia-among-binge-drinking-elderly-women-a-nationwide-population-based-study
#8
Jun-Il Yoo, Yong-Chan Ha, Young-Kyun Lee, Hana-Choi, Moon-Jib Yoo, Kyung-Hoi Koo
BACKGROUND: Alcohol consumption is considered a risk factor for sarcopenia, but the association between alcohol consumption and the prevalence of sarcopenia has not been evaluated in detail. This study was to identify the relationship between alcohol drinking patterns and the prevalence of sarcopenia in the elderly Korean population. METHODS: The cross-sectional study was performed using data from the Korea National Health and Nutrition Examination Survey. Participants were excluded if they were under the age of 65, or if data was not available regarding skeletal muscle mass or dietary intake...
May 30, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28554727/testosterone-modulates-foxo3a-and-p53-related-genes-to-protect-c2c12-skeletal-muscle-cells-against-apoptosis
#9
Lucía Pronsato, Lorena Milanesi, Andrea Vasconsuelo, Anabela La Colla
The loss of muscle mass and strength with aging, sarcopenia, is a prevalent condition among the elderly, associated with skeletal muscle dysfunction and enhanced muscle cell apoptosis. We have previously demonstrated that testosterone protects against H2O2-induced apoptosis in C2C12 muscle cells, at different levels: morphological, biochemical and molecular. Since we have observed that testosterone reduces p-p53 and maintains the inactive state of FoxO3a transcription factor, induced by H2O2, we analyzed if the hormone was exerting its antiapoptotic effect at transcriptional level, by modulating pro and antiapoptotic genes associated to them...
May 26, 2017: Steroids
https://www.readbyqxmd.com/read/28549989/overweight-in-elderly-people-induces-impaired-autophagy-in-skeletal-muscle
#10
Yaiza Potes, Beatriz de Luxán-Delgado, Susana Rodriguez-González, Marcela Rodrigues Moreira Guimarães, Juan J Solano, María Fernández-Fernández, Manuel Bermúdez, Jose A Boga, Ignacio Vega-Naredo, Ana Coto-Montes
Sarcopenia is the gradual loss of skeletal muscle mass, strength and quality associated with aging. Changes in body composition, especially in skeletal muscle and fat mass are crucial steps in the development of chronic diseases. We studied the effect of overweight on skeletal muscle tissue in elderly people without reaching obesity to prevent this extreme situation. Overweight induces a progressive protein breakdown reflected as a progressive withdrawal of anabolism against the promoted catabolic state leading to muscle wasting...
May 23, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28539380/sarcopenic-obesity-weight-loss-and-mortality-the-english-longitudinal-study-of-ageing
#11
Mark Hamer, Gary O'Donovan
Background: Age-related sarcopenia describes the loss of muscle strength and often accompanies an increase in adiposity in the elderly.Objective: We examined the association of sarcopenic obesity and changes in muscle strength and weight with the risk of mortality.Design: Participants (n = 6864) were community-dwelling men and women (45.6% men; 54.4% women; mean ± SD age: 66.2 ± 9.5 y) from the English Longitudinal Study of Ageing. Handgrip strength and body mass index (BMI; in kg/m(2)) were measured at baseline and at a 4-y follow-up...
May 24, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28539168/effectiveness-of-nutritional-supplementation-on-sarcopenia-and-recovery-in-hip-fracture-patients-a-multi-centre-randomized-trial
#12
Vincenzo Malafarina, Francisco Uriz-Otano, Concetta Malafarina, J Alfredo Martinez, M Angeles Zulet
BACKGROUND AND OBJECTIVES: Functional deterioration and reduced mobility in elderly patients with a hip fracture are associated with a loss of both muscle mass and function (sarcopenia). The aim of this study was to assess whether oral nutritional supplementation (ONS) improves muscle mass and nutritional markers (BMI, proteins) in elderly patients with hip fracture. METHODS: Patients aged 65 years and over with hip fractures admitted to either of two rehabilitation facilities were included...
July 2017: Maturitas
https://www.readbyqxmd.com/read/28537342/assessing-the-risk-of-sarcopenia-in-the-elderly-the-mini-sarcopenia-risk-assessment-msra-questionnaire
#13
A P Rossi, R Micciolo, S Rubele, F Fantin, C Caliari, E Zoico, G Mazzali, E Ferrari, S Volpato, M Zamboni
OBJECTIVES: to validate the MSRA questionnaire proposed as prescreening tool for sarcopenia, in a population of community-dwelling elderly subjects. DESIGN: observational study. SETTING: community dwelling elderly subjects. PARTICIPANTS: 274 community dwelling elderly subjects, 177 women and 97 men, aged 66-78 years. MEASUREMENTS: Based on EWGSOP diagnostic criteria subjects were classified as sarcopenic and non-sarcopenic...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28523252/prevalence-of-sarcopenia-in-the-world-a-systematic-review-and-meta-analysis-of-general-population-studies
#14
REVIEW
Gita Shafiee, Abbasali Keshtkar, Akbar Soltani, Zeinab Ahadi, Bagher Larijani, Ramin Heshmat
BACKGROUND: Sarcopenia, an age-related decline in muscle mass and function, is one of the most important health problems in elderly with a high rate of adverse outcomes. However, several studies have investigated the prevalence of sarcopenia in the world, the results have been inconsistent. The current systematic review and meta- analysis study was conducted to estimate the overall prevalence of sarcopenia in both genders in different regions of the world. METHODS: Electronic databases, including MEDLINE (via PubMed), SCOPUS and Web of Science were searched between January 2009 and December 2016...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/28511733/similarities-and-interactions-between-the-ageing-process-and-high-chronic-intake-of-added-sugars
#15
Eva Gatineau, Sergio Polakof, Dominique Dardevet, Laurent Mosoni
In our societies, the proportions of elderly people and of obese individuals are increasing. Both factors are associated with high health-related costs. During obesity, many authors suggest that it is a high chronic intake of added sugars (HCIAS) that triggers the shift towards pathology. However, the majority of studies were performed in young subjects and only a few were interested in the interaction with the ageing process. Our purpose was to discuss the metabolic effects of HCIAS, compare with the effects of ageing, and evaluate how deleterious the combined action of HCIAS and ageing could be...
May 17, 2017: Nutrition Research Reviews
https://www.readbyqxmd.com/read/28502778/the-joint-association-of-insulin-sensitivity-and-physical-activity-on-the-skeletal-muscle-mass-and-performance-in-community-dwelling-older-adults
#16
Chuan-Wei Yang, Chia-Ing Li, Tsai-Chung Li, Chiu-Shong Liu, Chih-Hsueh Lin, Wen-Yuan Lin, Cheng-Chieh Lin
BACKGROUND: Many well-known risk factors that may lead to sarcopenia are already discovered. However, their combined effects on sarcopenia components remain unclear. This study aims to explore the joint association of physical activity and insulin sensitivity on skeletal muscle mass and performance of Taiwanese elder people from a metropolitan community. METHODS: The study sample involved 844 elders who were examined through dual energy X-ray absorptiometry and who underwent tests for fasting blood glucose and serum insulin level...
September 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28501109/sarcopenia-a-new-predictor-of-postoperative-complications-for-elderly-gastric-cancer-patients-who-underwent-radical-gastrectomy
#17
Chong-Jun Zhou, Feng-Min Zhang, Fei-Yu Zhang, Zhen Yu, Xiao-Lei Chen, Xian Shen, Cheng-Le Zhuang, Xiao-Xi Chen
BACKGROUND: A geriatric assessment is needed to identify high-risk elderly patients with gastric cancer. However, the current geriatric assessment has been considered to be either time-consuming or subjective. The present study aimed to investigate the predictive effect of sarcopenia on the postoperative complications for elderly patients who underwent radical gastrectomy. MATERIALS AND METHODS: We conducted a prospective study of patients who underwent radical gastrectomy from August 2014 to December 2015...
May 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28493406/beta-hydroxy-beta-methylbutyrate-supplementation-and-skeletal-muscle-in-healthy-and-muscle-wasting-conditions
#18
REVIEW
Milan Holeček
Beta-hydroxy-beta-methylbutyrate (HMB) is a metabolite of the essential amino acid leucine that has been reported to have anabolic effects on protein metabolism. The aims of this article were to summarize the results of studies of the effects of HMB on skeletal muscle and to examine the evidence for the rationale to use HMB as a nutritional supplement to exert beneficial effects on muscle mass and function in various conditions of health and disease. The data presented here indicate that the beneficial effects of HMB have been well characterized in strength-power and endurance exercise...
May 10, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28477106/sarcopenia-in-gastric-cancer-when-the-loss-costs-too-much
#19
REVIEW
Elena Ongaro, Vanessa Buoro, Marika Cinausero, Riccardo Caccialanza, Annalisa Turri, Valentina Fanotto, Debora Basile, Maria Grazia Vitale, Paola Ermacora, Giovanni Gerardo Cardellino, Laura Nicoletti, Lorenzo Fornaro, Andrea Casadei-Gardini, Giuseppe Aprile
Sarcopenia is a complex syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength. Malignancy is a major determinant of sarcopenia, and gastric cancer (GC) is among the most common causes of this phenomenon. As sarcopenia is a well-recognized poor prognostic feature in GC and has been associated with worse tolerance of surgical and medical treatments, members of the multidisciplinary team should be aware of the clinical relevance, pathogenic mechanisms, and potential treatments for this syndrome...
May 5, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28437312/assessment-of-sarcopenia-as-a-predictor-of-poor-outcomes-after-esophagectomy-in-elderly-patients-with-esophageal-cancer
#20
Yuichiro Nakashima, Hiroshi Saeki, Ryota Nakanishi, Masahiko Sugiyama, Junji Kurashige, Eiji Oki, Yoshihiko Maehara
OBJECTIVE: The objective of the study was to elucidate the impact of sarcopenia in elderly patients with esophageal cancer on postoperative complications and long-term survival after surgery for esophageal cancer. SUMMARY BACKGROUND DATA: Sarcopenia, defined as loss of skeletal muscle mass with age, has been identified as a poor prognostic factor for malignancies. This retrospective study investigated the effect of sarcopenia on surgical outcomes among young and elderly patients with esophageal cancer...
April 21, 2017: Annals of Surgery
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