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sarcopenia in elder

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https://www.readbyqxmd.com/read/29760608/calf-circumference-as-a-simple-screening-marker-for-diagnosing-sarcopenia-in-older-korean-adults-the-korean-frailty-and-aging-cohort-study-kfacs
#1
Sunyoung Kim, Miji Kim, Yunhwan Lee, ByungSung Kim, Tai Young Yoon, Chang Won Won
Background: The purpose of this study was to explore the optimal cut-off point of calf circumference (CC) as a simple proxy marker of appendicular skeletal muscle mass (ASM) and sarcopenia in the Korean elderly and to test the criterion-related validity of CC by analyzing its relationships with the physical function. Methods: The participants were 657 adults aged 70 to 84 years who had completed both dual energy X-ray absorptiometry (DXA) and physical function test in the first baseline year of the Korean Frailty and Aging Cohort Study...
May 14, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29753582/the-biomarkers-associated-with-sarcopenia-and-physical-frailty-in-elderly-persons-biosphere-study-rationale-design-and-methods
#2
Riccardo Calvani, Anna Picca, Federico Marini, Alessandra Biancolillo, Matteo Cesari, Vito Pesce, Angela Maria Serena Lezza, Maurizio Bossola, Christiaan Leeuwenburgh, Roberto Bernabei, Francesco Landi, Emanuele Marzetti
Sarcopenia, the progressive and generalised loss of muscle mass and strength/function, is a major health issue in older adults given its high prevalence and burdensome clinical implications. Over the years, this condition has been endorsed as a marker for discriminating biological from chronological age. However, the absence of a unified operational definition has hampered its full appreciation by healthcare providers, researchers and policy-makers. In addition to this unsolved debate, the complexity of musculoskeletal ageing represents a major challenge to the identification of clinically meaningful biomarkers...
May 10, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29739477/selected-b-vitamins-and-their-possible-link-to-the-aetiology-of-age-related-sarcopenia-relevance-of-uk-dietary-recommendations
#3
N Aytekin, K N Mileva, A D Cunliffe
The possible roles of selected B vitamins in the development and progression of sarcopenia are reviewed. Age-related declines in muscle mass and function are associated with huge and increasing costs to healthcare providers. Falls and loss of mobility and independence due to declining muscle mass/function are associated with poor clinical outcomes and their prevention and management are attractive research targets. Nutritional status appears a key modifiable and affordable intervention. There is emerging evidence of sarcopenia being the result not only of diminished anabolic activity but also of declining neurological integrity in older age, which is emerging as an important aspect of the development of age-related decline in muscle mass/function...
May 9, 2018: Nutrition Research Reviews
https://www.readbyqxmd.com/read/29737798/malnutrition-and-chronic-inflammation-as-risk-factors-for-sarcopenia-in-elderly-patients-with-hip-fracture
#4
Jun-Il Yoo, Yong-Chan Ha, Hana Choi, Kyu-Hwang Kim, Young-Kyun Lee, Kyung-Hoi Koo, Ki-Soo Park
BACKGROUND AND OBJECTIVES: To evaluate malnutrition and chronic inflammation as risk factors for sarcopenia in elderly patients with hip fractures, as defined by the criteria of the Asian Working Group on Sarcopenia (AWGS). METHODS AND STUDY DESIGN: A total of 327 elderly patients with hip fractures were enrolled in this retrospective observational study. The main outcome measure was the nutritional status and nutritional risk factors for sarcopenia in elderly patients...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29736711/isolation-of-skeletal-muscle-stem-cells-for-phenotypic-screens-for-modulators-of-proliferation
#5
Aaron C Hinken, Andrew N Billin
Adult skeletal muscle contains a population of resident stem cells known as muscle stem cells (MuSC) or satellite cells. This population of cells is required for regeneration of functional myofibers after damage. Aging reduces the proliferative response of satellite cells post-injury. This deficient response is thought to contribute to slowed recovery of muscle function after damage in the elderly and may also contribute to age-related loss of muscle function (sarcopenia). Numerous techniques are now available for the isolation of highly purified satellite cells from mice and humans (Sherwood, et al...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29727228/osteosarcopenia
#6
James Paintin, Cyrus Cooper, Elaine Dennison
Osteosarcopenia is a newly described syndrome that describes the co-existence of osteoporosis and sarcopenia, two chronic musculoskeletal conditions associated with ageing. Osteoporosis, a condition of low bone mass and micro-architectural deterioration of bone, and sarcopenia, the loss of muscle mass, strength and function, often co-exist in a frail subset of the elderly population, leading to significantly worsened outcomes than seen in either condition alone. These include a greater risk of falls, fractures and institutionalization, and significant socioeconomic costs...
May 2, 2018: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/29723655/effects-of-aging-and-insulin-resistant-states-on-protein-anabolic-responses-in-older-adults
#7
REVIEW
Jose A Morais, Kathryn Jacob, Stéphanie Chevalier
Insulin is the principal postprandial anabolic hormone and resistance to its action could contribute to sarcopenia. We developed different types of hyperinsulinemic clamp protocols to measure glucose and protein metabolism in insulin resistant states (older adults, obesity, diabetes, etc.). To define effects of healthy aging in response to insulin, we employed the hyperinsulinemic, euglycemic and isoaminoacidemic (HYPER-1) clamp. The net whole-body anabolic (protein balance) response to hyperinsulinemia was lower in the elderly vs young (p = 0...
April 30, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29682215/oxidative-stress-role-of-physical-exercise-and-antioxidant-nutraceuticals-in-adulthood-and-aging
#8
REVIEW
Carolina Simioni, Giorgio Zauli, Alberto M Martelli, Marco Vitale, Gianni Sacchetti, Arianna Gonelli, Luca M Neri
Physical exercise is considered to be one of the beneficial factors of a proper lifestyle and is nowadays seen as an indispensable element for good health, able to lower the risk of disorders of the cardiovascular, endocrine and osteomuscular apparatus, immune system diseases and the onset of potential neoplasms. A moderate and programmed physical exercise has often been reported to be therapeutic both in the adulthood and in aging, since capable to promote fitness. Regular exercise alleviates the negative effects caused by free radicals and offers many health benefits, including reduced risk of all-cause mortality, sarcopenia in the skeletal muscle, chronic disease, and premature death in elderly people...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29680239/protein-and-peptides-for-elderly-health
#9
Nan Shang, Chalamaiah Meram, Nandika Bandara, Jianping Wu
The world is aging rapidly; thus, the management of elderly health at an advanced age poses a new research challenge. The elderly is vulnerable to not only malnutrition but also hypofunction of all organs and a variety of chronic diseases such as sarcopenia, osteoporosis, gastrointestinal dysfunction, and mental problems. As the major macronutrient, food protein plays an important role in elderly health and well-being. In this chapter, the function of protein and peptide in elderly health as well as their effects on preventing aging-related disease is reviewed...
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29673541/appropriate-protein-intake-is-one-strategy-in-the-management-of-metabolic-syndrome-in-korean-elderly-to-mitigate-changes-in-body-composition
#10
Chorong Oh, Jae-Kyung No
Higher protein intake could reduce metabolic syndrome (MetS) by managing body composition among Korean elderly although the research is scant. Herein, we examined the hypothesis that the optimal protein intake of Korean elderly is associated with both improvements in MetS risk as well as favorable changes in body composition. The present study employs a national data source, the Korea National Health and Nutrition Examination Survey (KNHANES, 2009), and a total 1,567 elderly (651 men and 916 women) were included in the final data analyses...
March 2018: Nutrition Research
https://www.readbyqxmd.com/read/29673501/association-of-sarcopenia-with-nutritional-parameters-quality-of-life-hospitalization-and-mortality-rates-of-elderly-patients-on-hemodialysis
#11
Juliana Giglio, Maria Ayako Kamimura, Fernando Lamarca, Juliana Rodrigues, Fernanda Santin, Carla Maria Avesani
OBJECTIVE: This study aimed to assess whether diminished muscle mass, diminished muscle strength, or both conditions (sarcopenia) are associated with worse nutritional status, poor quality of life (QoL), and hard outcomes, such as hospitalization and mortality, in elderly patients on maintenance hemodialysis (MHD). DESIGN AND SUBJECTS: This is a multicenter observational longitudinal study that included 170 patients on MHD (age 70 ± 7 years, 65% male) from 6 dialysis centers...
May 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29671766/protein-intake-and-distribution-in-relation-to-physical-functioning-and-quality-of-life-in-community-dwelling-elderly-people-acknowledging-the-role-of-physical-activity
#12
Dominique S M Ten Haaf, Ellen J I van Dongen, Malou A H Nuijten, Thijs M H Eijsvogels, Lisette C P G M de Groot, Maria T E Hopman
Increasing total protein intake and a spread protein intake distribution are potential strategies to attenuate sarcopenia related loss of physical function and quality of life. The aim of this cross-sectional study was to investigate whether protein intake and protein intake distribution are associated with muscle strength, physical function and quality of life in community-dwelling elderly people with a wide range of physical activity. Dietary and physical activity data were obtained from two studies (N = 140, age 81 ± 6, 64% male), with the following outcome measures: physical functioning (Short Physical Performance Battery (SPPB), comprising balance, gait speed and chair rise tests), handgrip strength and quality of life (EQ-5D-5L)...
April 19, 2018: Nutrients
https://www.readbyqxmd.com/read/29655775/relationship-between-water-intake-and-skeletal-muscle-mass-in-elderly-koreans-a-nationwide-population-based-study
#13
Jun-Il Yoo, Hana Choi M D, Sang-Yoon Song, Ki-Soo Park, Dong-Hoon Lee, Yong-Chan Ha
OBJECTIVES: The purposes of this study were to evaluate the correlation between sarcopenia and water intake and investigate lack of daily water intake in the presence of sarcopenia in an elderly population. METHODS: Data from 3656 participants (1582 men and 2074 women) were analyzed using the Korea National Health and Nutrition Examination Survey. Sarcopenia was defined in accordance with the criteria of the Asia Working Group for Sarcopenia. Water intake was assessed using the dietary water adequacy ratio and was calculated by dividing the daily water intake from fluid by the recommended daily amount of 1000 mL in men and 900 mL in women...
February 12, 2018: Nutrition
https://www.readbyqxmd.com/read/29624960/associated-factors-with-sarcopenia-among-mexican-elderly-2012-national-health-and-nutrition-survey
#14
(no author information available yet)
Background: Sarcopenia involves the loss of skeletal muscle mass and age-related functionality; it diminishes physical independence, health and quality of life. In 2016 it was added to the International Classification of Diseases (ICD-10). Information about the frequency of sarcopenia among Mexican older adults is scarce. The objective was to analyze associated factors with sarcopenia in Mexican older adults through the 2012 National Health and Nutrition Survey data. Methods: Cross-sectional study which included subjects of 60 years of age or more with simultaneous information on health and anthropometry questionnaires from the 2012 National Health and Nutrition Survey...
2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29624343/oxidative-stress-in-the-elderly-with-diabetes-mellitus-or-hypertension
#15
Aleida Rodríguez-Castañeda, Katia Leticia Martínez-González, Rosalinda Sánchez-Arenas, Sergio Sánchez-García, Israel Grijalva, Lourdes Basurto-Acevedo, Juan Cuadros-Moreno, Eliseo Ramírez-García, Paola García-de la Torre
Background: Mexico City has the highest aging rate in the country, as well as a high prevalence of diabetes mellitus (DM) and hypertension (HT). It is known that each one of these conditions increase oxidative stress (OS) independently. Methods: With this study we described changes in OS of 18 patients without DM or HT (controls), 12 with DM, 23 with HT, and 18 with DM and HT, all of them members of the COSFAMM (Cohorte de Obesidad, Sarcopenia y Fragilidad en Adultos Mayores de México)...
2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29623651/is-iron-accumulation-a-possible-risk-factor-for-sarcopenia
#16
Guoyang Zhao
Sarcopenia has a high incidence among the elderly, with significant negative effects on the quality of life. The pathogenesis of sarcopenia is complex, and many factors are involved in its development and progression. Sarcopenia might be associated with iron accumulation given that (1) age-related iron accumulation was found in the skeletal muscle, (2) excess iron could cause skeletal muscle damage or atrophy, and (3) patients with sarcopenia showed higher levels of serum ferritin. Understanding the etiology and pathogenesis of sarcopenia would help to develop new treatment and preventive methods, thereby improving the quality of life of the elderly patients...
April 5, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29619149/appendicular-skeletal-muscle-mass-reference-values-and-the-peak-muscle-mass-to-identify-sarcopenia-among-iranian-healthy-population
#17
Gita Shafiee, Afshin Ostovar, Ramin Heshmat, Abbas Ali Keshtkar, Farshad Sharifi, Zhaleh Shadman, Iraj Nabipour, Akbar Soltani, Bagher Larijani
Background: Sacopenia is a common problem in elderly with the adverse outcomes. The objective of this study was to estimate the peak appendicular skeletal muscle mass (ASM) and age of its attainment by sex among the Iranian population. Methods: A total of 691 men and women aged 18-94 years participated in this cross-sectional, population-based study in Bushehr, Iran. ASM was measured by dual X-ray absorptiometry. Cutoff points for men and women were established considering two standard deviations (SDs) below the mean values of the skeletal muscle index (SMI) for young reference groups...
2018: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29614534/-current-concepts-of-cardiologic-therapies-in-the-elderly
#18
Ursula Müller-Werdan, Kristina Norman
MYOCARDIAL INFARCTION IN THE OLD PATIENT: Even old patients may crucially benefit from reopening the occluded coronary artery by percutaneous coronary intervention with stent implantation. Bleeding complications can be reduced by choosing the radial instead of the femoral vascular approach for cardiac catheterization. STATINS FOR THE ELDERLY: WHEN TO START UND WHEN TO STOP?: Elderly benefit no less than the younger from statins. "Goal-oriented statin therapy" is preferable to the "statin strategy of fixed dose"...
April 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29604401/limb-muscle-quality-and-quantity-in-elderly-adults-with-dynapenia-but-not-sarcopenia-an-ultrasound-imaging-study
#19
Ke-Vin Chang, Wei-Ting Wu, Kuo-Chin Huang, Wei Han Jan, Der-Sheng Han
BACKGROUND: Dynapenia is prevalent in people with reduced skeletal muscle mass, i.e. sarcopenia, but a certain population develops muscle strength loss despite having normal skeletal muscle volume. To date, studies investigating muscle quality and quantity in groups with dynapenia but not sarcopenia are limited. METHODS: Echogenicity and thickness of the biceps brachii, triceps brachii, rectus femoris, and medial gastrocnemius muscles were measured using high-resolution ultrasonography in 140 community-dwelling elderly adults...
March 28, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29604268/mild-aerobic-training-with-blood-flow-restriction-increases-the-hypertrophy-index-and-musk-in-both-slow-and-fast-muscles-of-old-rats-role-of-pgc-1%C3%AE
#20
Mohammad-Ali Bahreini Pour, Siyavash Joukar, Fariborz Hovanloo, Hamid Najafipour, Vida Naderi, Alireza Raji, Saeed Esmaeili-Mahani
AIMS: Existing evidence emphasize the role of mitochondrial dysfunction in sarcopenia which is revealed as loss of skeletal muscle mass and neuromuscular junction remodeling. We assessed the effect of low-intensity aerobic training along with blood flow restriction on muscle hypertrophy index, muscle-specific kinase (MuSK), a pivotal protein of the neuromuscular junction and Peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC-1α) in aged male rats. MAIN METHODS: Animals groups were control (CTL), sham (Sh), leg blood flow restriction (BFR), exercise (Ex), sham + exercise (Sh + Ex), and BFR plus exercise (BFR + Ex) groups...
March 28, 2018: Life Sciences
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