keyword
MENU ▼
Read by QxMD icon Read
search

sarcopenia in elder

keyword
https://www.readbyqxmd.com/read/29141602/association-between-sarcopenia-and-low-back-pain-in-local-residents-prospective-cohort-study-from-the-gaina-study
#1
Shinji Tanishima, Hiroshi Hagino, Hiromi Matsumoto, Chika Tanimura, Hideki Nagashima
BACKGROUND: Low back pain (LBP) is one of the most common ailments that people experience in their lifetime. On the other hands, Sarcopenia also leads to several physical symptoms and contributes to reducing the quality of life of elderly people.The purpose of this study is to investigate the association between sarcopenia and low back pain among the general population. METHODS: The subjects included 216 adults (79 men and 137 women; mean age, 73.5 years) undergoing a general medical examination in Hino, Japan...
November 15, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29127513/pentosidine-concentration-is-associated-with-degenerative-lumbar-scoliosis-in-older-women-preliminary-results
#2
Yawara Eguchi, Toru Toyoguchi, Kazuhide Inage, Kazuki Fujimoto, Sumihisa Orita, Kazuyo Yamauchi, Miyako Suzuki, Hirohito Kanamoto, Koki Abe, Masaki Norimoto, Tomotaka Umimura, Masao Koda, Takeo Furuya, Yasuchika Aoki, Kazuhisa Takahashi, Seiji Ohtori
PURPOSE: Advanced glycation end products (AGEs) have been implicated in the pathogenesis of sarcopenia. The objective of the study was to investigate the prevalence of sarcopenia in degenerative lumbar scoliosis (DLS), and the relationship between biochemical markers including major AGEs, pentosidine, and DLS in older women. METHODS: Our study participants were 20 elderly women with idiopathic DLS (mean age 76.4 years, range 56-88). Nineteen age- and sex-matched volunteers (mean age 74...
November 10, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29120677/relationships-between-25-oh-d-concentration-sarcopenia-and-homa-ir-in-postmenopausal-korean-women
#3
J H Lee, S Kim, M K Kim, B H Yun, S Cho, Y S Choi, B S Lee, S K Seo
OBJECTIVE: Sarcopenia and insulin resistance are common co-morbidities in the elderly and are known to be associated with vitamin D deficiency. However, no previous studies have investigated interactions between all three of these factors. We aimed to investigate the relationship between 25-hydroxyvitamin D concentration, sarcopenia, and insulin resistance in postmenopausal Korean women. METHODS: This study used data from the Korea National Health and Nutrition Examination Survey 2008-2011...
November 9, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29093231/factors-related-with-handgrip-strength-in-elderly-patients
#4
Nur Riviati, Siti Setiati, Purwita W Laksmi, Murdani Abdullah
BACKGROUND: the aging process causes decreasing in the function of various organs. Skletal muscle is one of the organs affected by aging process. It is known as sarcopenia. Sarcopenia is defined as a syndrome characterized by progressive loss of muscle mass and strength. The handgrip strength examination is often applied as a sarcopenia filtering technique. This study aimed to determine the relationship between age, nutritional status, and chronic diseases such as stroke, hypertension (HT), diabetes mellitus (DM), coronary heart disease (CHD), and chronic obstructive pulmonary disease (COPD) with handgrip strength...
July 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29092672/the-impact-of-age-on-skeletal-muscle-progenitor-cell-survival-and-fate-after-injury
#5
Yu Zhou, Daniel Lovell, Maigen Bethea, Benyam Yoseph, James Poteracki, Shay Soker, Tracy Criswell
Sarcopenia is defined as the loss of skeletal muscle mass and function due to age, and represents a major cause of disability in the elderly population. The contributing factors to the onset of sarcopenia are not well defined, but appear to involve age-dependent changes in both the tissue micro-environment and muscle progenitor cell (MPC) population. MPC transplantation has the potential to be a novel therapy for treatment of muscle dysfunction due to aging or injury, but has not shown significant clinical efficacy to date...
November 1, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/29079029/relationship-between-sarcopenia-and-frailty-in-the-toledo-study-of-healthy-aging-a-population-based-cross-sectional-study
#6
B Davies, F García, I Ara, F Rodríguez Artalejo, L Rodriguez-Mañas, S Walter
INTRODUCTION: Frailty and sarcopenia are correlates of musculoskeletal aging that represent a state of vulnerability increasing the risk of negative health outcomes. Standardized definitions are lacking for both, and sometimes both concepts are used interchangeably. However, no large study has assessed the coexistence of these 2 entities in a cohort of older community-dwelling people. METHODS: Data were taken from the Toledo Study of Healthy Aging (TSHA), a study of community-dwelling elderly (≥65 years)...
October 24, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29074832/-update-on-recent-progress-in-vitamin-d-research-eldecalcitol-r-and-fall-prevention
#7
Takao Suzuki
In the elderly, vitamin D deficiency results not only in impaired bone mineralization, but also myopathy. Low vitamin D has also been shown to be associated with decline of muscle strength, sarcopenia, functional limitation, and disability. Several recent studies have shown that low serum vitamin D concentration is associated with lower physical function and falls in older adults. In this article, the author reviews a relationship between falls and serum vitamin D concentration of the elderly living in the community, and also introduces the major results from a recent randomized controlled trial on prevention of decline of fall-related balance performance by the treatment with newly developed active vitamin D(Eldecalcitol(R) )among the women with age 65 years old and over and diagnosed as osteoporosis...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/29074829/-update-on-recent-progress-in-vitamin-d-research-vitamin-d-and-muscle-tissues
#8
Ichiro Kaneko, Ken-Ichi Miyamoto, Takeshi Nikawa
In elderly people, vitamin D insufficiency may increase the risk of fracture, and may also be involved in the development of sarcopenia or cardiovascular decline. Recent studies using vitamin D receptor knockout mice unveiled multiple functions of vitamin D beyond bone and mineral metabolism. This review describes the actions of vitamin D in skeletal, cardiac, and vascular smooth muscle. Eldecalcitol, an active vitamin D analog developed for the treatment of osteoporosis, also effectively improved skeletal muscle function in vivo, and may have synergistic activities in bone and muscle...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/29052905/metabolic-changes-in-patients-with-prostate-cancer-during-androgen-deprivation-therapy
#9
REVIEW
Koji Mitsuzuka, Yoichi Arai
Androgen deprivation therapy continues to be widely used for the treatment of prostate cancer despite the appearance of new-generation androgen-receptor targeting drugs after 2000. Androgen deprivation therapy can alleviate symptoms in patients with metastatic prostate cancer and might have a survival benefit in some patients, but it causes undesirable changes in lipid, glucose, muscle or bone metabolism. These metabolic changes could lead to new onset or worsening of diseases, such as obesity, metabolic syndrome, diabetes mellitus, cardiovascular disease, sarcopenia or fracture...
October 20, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29050209/handgrip-strength-and-subclinical-carotid-atherosclerosis-in-relation-to-platelet-levels-among-hypertensive-elderly-japanese
#10
Yuji Shimizu, Shimpei Sato, Jun Koyamatsu, Hirotomo Yamanashi, Mako Nagayoshi, Koichiro Kadota, Shin-Ya Kawashiri, Keita Inoue, Yasuhiro Nagata, Takahiro Maeda
Age-related disruption of microvascular endothelium exacerbates hypertension and sarcopenia; and atherosclerosis is a well-known biological response to vascular endothelial injury. Therefore, prevalence of atherosclerosis among hypertensive elderly subjects may partly indicate the presence of an appropriate response to endothelial injury. We conducted a cross-sectional study of 795 elderly hypertensive Japanese subjects aged 60-89 years. Since platelet level is an indicator of vascular repair activity, subjects were stratified by platelet counts...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29046390/novel-sarcopenia-related-alterations-in-sarcomeric-protein-post-translational-modifications-in-skeletal-muscles-identified-by-top-down-proteomics
#11
Liming Wei, Zachery R Gregorich, Ziqing Lin, Wenxuan Cai, Yutong Jin, Susan H McKiernan, Sean McIlwain, Judd M Aiken, Richard L Moss, Gary M Diffee, Ying Ge
Sarcopenia, the age-related loss of skeletal muscle mass and strength, is a significant cause of morbidity in the elderly and is a major burden on health care systems. Unfortunately, the underlying molecular mechanisms in sarcopenia remain poorly understood. Herein, we utilized top-down proteomics to elucidate sarcopenia-related changes in the fast- and slow-twitch skeletal muscles of aging rats with a focus on the sarcomeric proteome, which includes both myofilament and Z-disc proteins-the proteins that constitute the contractile apparatuses...
October 18, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29021612/il-15-promotes-human-myogenesis-and-mitigates-the-detrimental-effects-of-tnf%C3%AE-on-myotube-development
#12
Mary F O'Leary, Graham R Wallace, Andrew J Bennett, Kostas Tsintzas, Simon W Jones
Studies in murine cell lines and in mouse models suggest that IL-15 promotes myogenesis and may protect against the inflammation-mediated skeletal muscle atrophy which occurs in sarcopenia and cachexia. The effects of IL-15 on human skeletal muscle growth and development remain largely uncharacterised. Myogenic cultures were isolated from the skeletal muscle of young and elderly subjects. Myoblasts were differentiated for 8 d, with or without the addition of recombinant cytokines (rIL-15, rTNFα) and an IL-15 receptor neutralising antibody...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28991145/use-of-sarcopenia-to-predict-risk-of-mortality-after-emergency-abdominal-surgery-in-elderly-patients
#13
Shi-Yu Wang, Fu-Shan Xue, Ya-Yang Liu, Gui-Zhen Yang
No abstract text is available yet for this article.
October 4, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28977377/fnih-defined-sarcopenia-predicts-adverse-outcomes-among-community-dwelling-older-people-in-taiwan-results-from-i-lan-longitudinal-aging-study
#14
Ting-Ching Tang, An-Chun Hwang, Li-Kuo Liu, Wei-Ju Lee, Liang-Yu Chen, Yi-Hui Wu, Chung-Yu Huang, Cheng-Hao Hung, Chih-Jen Wang, Ming-Hsien Lin, Li-Ning Peng, Liang-Kung Chen
Background: To evaluate the predictive validity of sarcopenia defined by the Foundation for the National Institutes of Health (FNIH) Sarcopenia Project among Asian older adults. Methods: Data of the I-Lan Longitudinal Aging Study were obtained for analysis. Overall, 1,839 community-dwelling people aged 50 years and older, capable of completing a 6-m walk, with life expectancy of more than 6 months, and not institutionalized at time of data collection were enrolled for study...
July 25, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28967718/outcomes-after-non-cardiac-surgery-mortality-complications-disability-and-rehospitalization
#15
Bruno Amato, Mario Santoro, Giuseppe Giugliano, Giuseppe Servillo, Veronica Di Nardo, Lorenza Di Domenico, Rita Compagna, Raffaele Izzo
In the last 25 years, the number of patients aged ≥75 years undergoing non-cardiac surgery has greatly increased. In elderly patients, frailty is significantly associated with an increased risk of adverse events, functional decline, procedural complications, prolonged hospitalization, and mortality. The relationship between frailty and increased mortality and morbidity requires an appropriate tool of assessment to accurately quantify the patient's clinical and perioperative conditions. The preoperative evaluation of elderly patients candidate for non-cardiac surgery should include assessment of frailty, sarcopenia and malnutrition, as these are related to high surgical risk...
July 18, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/28956710/fermented-rice-germ-extract-alleviates-morphological-and-functional-damage-to-murine-gastrocnemius-muscle-by-inactivation-of-amp-activated-protein-kinase
#16
Miyu Tanaka, Yuta Yoshino, Shogo Takeda, Kazuya Toda, Hiroshi Shimoda, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Hara
Sarcopenia, loss of muscle mass and function, is mainly observed in elderly people. In this study, we investigated whether fermented rice germ extract (FRGE) has some effects on the mouse gastrocnemius muscle by using behavioral and morphological analyses, Western blotting, and a murine model of immobilization-induced muscle atrophy. Daily oral FRGE administration increased muscle weight and strength. In addition, myofiber size in gastrocnemius muscle of FRGE-treated mice was increased as revealed by morphological quantification...
October 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28954714/baseline-functional-status-as-the-strongest-predictor-of-in-hospital-mortality-in-elderly-patients-with-non-valvular-atrial-fibrillation-results-of-the-nonavasc-registry
#17
A Gullón, F Formiga, M Camafort, J M Mostaza, J Díez-Manglano, J M Cepeda, I Novo-Veleiro, A Pose, C Suárez Fernández
OBJECTIVES: Atrial fibrillation (AF) has been associated with higher mortality. We aimed to identify the baseline predictors of in-hospital mortality among elderly patients with non-valvular AF (NVAF) hospitalised for any reason. METHODS: Observational, prospective and multicentre study was carried out on patients with NVAF over the age of 75, who had been admitted for any acute medical condition to Internal Medicine departments in Spain. RESULTS: We evaluated 804 patients with a mean age of 85±5...
September 24, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28934309/increased-plasma-proline-concentrations-are-associated-with-sarcopenia-in-the-elderly
#18
Kenji Toyoshima, Marie Nakamura, Yusuke Adachi, Akira Imaizumi, Tomomi Hakamada, Yasuko Abe, Eiji Kaneko, Soiciro Takahashi, Kentaro Shimokado
BACKGROUND AND PURPOSE: Metabolome analyses have shown that plasma amino acid profiles reflect various pathological conditions, such as cancer and diabetes mellitus. It remains unclear, however, whether plasma amino acid profiles change in patients with sarcopenia. This study therefore aimed to investigate whether sarcopenia-specific changes occur in plasma amino acid profiles. METHODS: A total of 153 community-dwelling and seven institutionalized elderly individuals (56 men, 104 women; mean age, 77...
2017: PloS One
https://www.readbyqxmd.com/read/28931495/a-review-of-sarcopenia-enhancing-awareness-of-an-increasingly-prevalent-disease
#19
REVIEW
Eric Marty, Yi Liu, Andre Samuel, Omer Or, Joseph Lane
Sarcopenia is defined as an age associated decline in skeletal muscle mass. The pathophysiology of sarcopenia is multifactorial, with decreased caloric intake, muscle fiber denervation, intracellular oxidative stress, hormonal decline, and enhanced myostatin signaling all thought to contribute. Prevalence rates are as high as 29% and 33% in elderly community dwelling and long-term care populations, respectively, with advanced age, low body mass index, and low physical activity as significant risk factors. Sarcopenia shares many characteristics with other disease states typically associated with risk of fall and fracture, including osteoporosis, frailty, and obesity...
December 2017: Bone
https://www.readbyqxmd.com/read/28903955/in-the-elderly-meat-protein-assimilation-from-rare-meat-is-lower-than-that-from-meat-that-is-well-done
#20
Caroline Buffière, Claire Gaudichon, Noureddine Hafnaoui, Carole Migné, Valérie Scislowsky, Nadezda Khodorova, Laurent Mosoni, Adeline Blot, Yves Boirie, Dominique Dardevet, Véronique Santé-Lhoutellier, Didier Rémond
Background: Meat cooking conditions in in vitro and in vivo models have been shown to influence the rate of protein digestion, which is known to affect postprandial protein metabolism in the elderly.Objectives: The present study was conducted to demonstrate the effect of cooking conditions on meat protein assimilation in the elderly. We used a single-meal protocol to assess the meat protein absorption rate and estimate postprandial meat protein utilization in elderly subjects.Design: The study recruited 10 elderly volunteers aged 70-82 y...
September 13, 2017: American Journal of Clinical Nutrition
keyword
keyword
109349
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"