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https://www.readbyqxmd.com/read/28705220/the-role-of-sports-clubs-in-helping-older-people-to-stay-active-and-prevent-frailty-a-longitudinal-mediation-analysis
#1
Paul Watts, Elizabeth Webb, Gopalakrishnan Netuveli
BACKGROUND: Frailty is a common syndrome in older adults characterised by increased vulnerability to adverse health outcomes as a result of decline in functional and physiological measures. Frailty predicts a range of poor health and social outcomes and is associated with increased risk of hospital admission. The health benefits of sport and physical activity and the health risks of inactivity are well known. However, less is known about the role of sports clubs and physical activity in preventing and managing frailty in older adults...
July 14, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28689573/rapid-geriatric-assessment-secondary-prevention-to-stop-age-associated-disability
#2
REVIEW
John E Morley
The Rapid Geriatric Assessment (RGA) measures frailty, sarcopenia, anorexia, cognition, and advanced directives. The RGA is a screen for primary care physicians to be able to detect geriatric syndromes. Early intervention when geriatric syndromes are recognized can decrease disability, hospitalization, and mortality.
August 2017: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/28689567/cognitive-frailty-mechanisms-tools-to-measure-prevention-and-controversy
#3
REVIEW
Bertrand Fougère, Julien Delrieu, Natalia Del Campo, Gaëlle Soriano, Sandrine Sourdet, Bruno Vellas
Physical frailty is often associated with cognitive impairment, possibly because of common underlying pathophysiologic mechanisms. To stimulate research in this field, the concept cognitive frailty was proposed, emphasizing the important role of brain aging. Cognitive frailty was defined as the presence of cognitive deficits in physically frail older persons without dementia. This subtype of frailty is deemed important, as it may represent a prodromal phase for neurodegenerative diseases and is potentially a suitable target for early intervention...
August 2017: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/28683956/strategies-for-selecting-the-optimal-treatment-in-newly-diagnosed-multiple-myeloma-patients
#4
REVIEW
Mary Steinbach, Tiffany Richards, Beth Faiman
OBJECTIVE: To review the current evidence on strategies for selecting the optimal treatment for newly diagnosed patients with multiple myeloma (MM). DATA SOURCES: Journal articles, research reports, state of the science papers, and clinical practice guidelines. CONCLUSION: Despite the plethora of drugs to effectively treat MM, the optimal induction regimen for patients with newly diagnosed MM is unknown. Rapid control of the disease, appropriate treatment selection and effective supportive care strategies remain integral to prevention and management of the disease...
July 3, 2017: Seminars in Oncology Nursing
https://www.readbyqxmd.com/read/28683406/crimes-against-the-elderly-in-italy-2007-2014
#5
Claudio Terranova, Greta Bevilacqua, Margherita Zen, Massimo Montisci
Crimes against the elderly have physical, psychological, and economic consequences. Approaches for mitigating them must be based on comprehensive knowledge of the phenomenon. This study analyses crimes against the elderly in Italy during the period 2007-2014 from an epidemiological viewpoint. Data on violent and non-violent crimes derived from the Italian Institute of Statistics were analysed in relation to trends, gender and age by linear regression, T-test, and calculation of the odds ratio with a 95% confidence interval...
June 27, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28679416/management-of-frailty-a-protocol-of-a-network-meta-analysis-of-randomized-controlled-trials
#6
Ahmed M Negm, Courtney C Kennedy, Lehana Thabane, Areti-Angeliki Veroniki, Jonathan D Adachi, Julie Richardson, Ian D Cameron, Aidan Giangregorio, Alexandra Papaioannou
BACKGROUND: Frailty is a common syndrome affecting 5-17% of community-dwelling older adults. Various interventions are used to prevent or treat frailty. Given the diversity of singular and multi-faceted frailty interventions, not all of them have been compared in head-to-head studies. Network meta-analyses provide an approach to simultaneous consideration of the relative effectiveness of multiple treatment alternatives. This systematic review and network meta-analysis of RCTs aims to determine the comparative effect of interventions targeting the prevention or treatment of frailty...
July 5, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28678345/the-effect-of-intentional-weight-loss-on-fracture-risk-in-persons-with-diabetes-results-from-the-look-ahead-randomized-clinical-trial
#7
Karen C Johnson, George A Bray, Lawrence J Cheskin, Jeanne M Clark, Caitlin M Egan, John P Foreyt, Katelyn R Garcia, Stephen Glasser, Frank L Greenway, Edward W Gregg, Helen P Hazuda, Andrea Hergenroeder, James O Hill, Edward S Horton, John M Jakicic, Robert W Jeffery, Steven E Kahn, William C Knowler, Cora E Lewis, Marsha Miller, Maria G Montez, David M Nathan, Jennifer L Patricio, Anne L Peters, Xavier Pi-Sunyer, Henry J Pownall, David Reboussin, J Bruce Redmon, Helmut Steinberg, Thomas A Wadden, Lynne E Wagenknecht, Rena R Wing, Catherine R Womack, Susan Z Yanovski, Ping Zhang, Ann V Schwartz
Intentional weight loss is an important treatment option for overweight persons with type 2 diabetes mellitus (DM), but the effects on long term fracture risk are not known. The purpose of this Look AHEAD analysis was to evaluate whether long term intentional weight loss would increase fracture risk in overweight or obese persons with DM. Look AHEAD is a multicenter, randomized clinical trial. Recruitment began in August 2001 and follow-up continued for a median of 11.3 years at 16 academic centers. 5145 persons aged 45 - 76 with DM were randomized to either an intensive lifestyle intervention (ILI) with reduced calorie consumption and increased physical activity designed to achieve and maintain ≥7% weight loss or to diabetes support and education intervention (DSE)...
July 5, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28669464/frailty-and-sarcopenia-newly-emerging-and-high-impact-complications-of-diabetes
#8
REVIEW
Alan J Sinclair, Ahmed H Abdelhafiz, Leocadio Rodríguez-Mañas
Diabetes increases the risk of physical dysfunction and disability. Diabetes-related complications and coexisting morbidities partially explain the deterioration in physical function. The decline in muscle mass, strength and function associated with diabetes leads to sarcopenia, frailty and eventually disability. Frailty acts as a mediator in the pathogenesis of disability in older people with diabetes and its measurement in routine daily practice is recommended. Frailty is a dynamic process which progresses from a robust condition to a pre-frail stage then frailty and eventually disability...
May 12, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28664287/-musculoskeletal-factors-sarcopenia-and-falls-in-old-age
#9
REVIEW
Daniel Schoene, Eva Kiesswetter, Cornel C Sieber, Ellen Freiberger
Falls in older adults are a major public health problem with a high incidence and severe consequences for the older individual. The age-related loss of muscle strength as well as muscle mass and muscle function (sarcopenia) are i) risk factors for falling, ii) associated with physical function and iii) markers of the frailty syndrome. Muscle function appears to play a bigger role than muscle mass. The operationalization of sarcopenia using the European Working Group on Sarcopenia in Older People (EWGSOP) algorithm is consistently associated with falling events...
June 29, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28663354/feeding-the-microbiota-transducer-of-nutrient-signals-for-the-host
#10
REVIEW
Fergus Shanahan, Douwe van Sinderen, Paul W O'Toole, Catherine Stanton
Advances in microbiome science cast light on traditional concepts on nutritional science, and are poised for clinical translation. Epidemiologic observations which linked lifestyle factors to risk of disease are being re-interpreted with mechanistic insight based on improved understanding of the microbiota. Examples include the role of dietary fibre in disease prevention, the deleterious effects of highly restricted diets, and the contribution of the microbiota to over- and undernutrition. While the microbiota transduces nutrient signals for the host, food and habitual diet shape the composition of the gut microbiota at every stage of life...
June 29, 2017: Gut
https://www.readbyqxmd.com/read/28656599/sleep-complaints-are-associated-with-frailty-in-mexican-older-adults-in-a-rural-setting
#11
Karla Moreno-Tamayo, Betty Manrique-Espinoza, Oscar Rosas-Carrasco, Alejandro Pérez-Moreno, Aarón Salinas-Rodríguez
AIM: The aim of the present study was to examine the association between sleep complaints and frailty status in a cohort of older adults from rural Mexico, and determine if this association varies according to sex. METHODS: A cross-sectional study was carried out on a total of 591 community-dwelling adults aged ≥70 years in rural settings of Mexico. Sleep complaints were based on self-reported sleep problems. Frailty status was assessed according to the Fried et al...
June 28, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28649108/-aging-and-homeostasis-prevention-and-treatment-of-sarcopenia-and-frailty
#12
Hidenori Arai
Frailty and sarcopenia are geriatrics syndromes that are increasing in the super aged society and are an important risk factor for the outcomes such as disability, falls, falls/fractures, and death. Although aging is a major factor in both syndromes, muscle weakness is accelerated by malnutrition such as protein and vitamin D deficiency and lack of exercise in a sedentary lifestyle. Therefore, nutritional guidance and exercise instruction are extremely important as well as management of diseases in older people...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28646457/national-survey-among-radiation-oncology-residents-related-to-their-needs-in-geriatric-oncology
#13
Rachel Leifer, Bonnie Bristow, Martine Puts, Shabbir Alibhai, Xingshan Cao, Barbara-Ann Millar, Meredith Giuliani, Tina Hsu, Maureen Trudeau, Rajin Mehta, Ines Menjak, Mireille Norris, Barbara Liu, Francois Gallant, Ewa Szumacher
Currently, there is no formal curriculum addressing geriatric oncology within Canadian radiation oncology (RO) residency programs. Knowledge related to geriatric medicine may help radiation oncologists modify RT based on frailty status and geriatric considerations. Understanding specific learning needs allow program coordinators to align the current curriculum with residents' geriatric oncology learning needs. The purpose of this study is to determine the geriatric oncology educational needs of the Canadian RO residents and to inform Canadian RO residency training...
June 24, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28641903/-effectiveness-of-physical-exercise-on-fitness-in-frail-older-adults-a-systematic-review-of-randomised-trials
#14
Maria Viladrosa, Carles Casanova, Angela Claudia Ghiorghies, Pilar Jürschik
Performing exercise to maintain a good physical condition is crucial to improve and prevent frailty in older adults. The aim of this review was to assess the beneficial effects of physical exercise on fitness in frail older adults. A thorough literature search of randomised clinical trials (RCT) in the last 15 years was performed on different electronic databases. The methodological assessment of studies was obtained using the PEDro scale. Ten RCT were included, providing a final sample of 1,130 individuals...
June 19, 2017: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/28632933/patient-characteristics-associated-with-a-successful-response-to-nurse-led-care-programs-targeting-the-oldest-old-a-comparison-of-two-rcts
#15
Nienke Bleijenberg, Lorenz Imhof, Romy Mahrer-Imhof, Margaret I Wallhagen, Niek J de Wit, Marieke J Schuurmans
BACKGROUND: To improve the effectiveness of community-based care programs, especially those targeting the oldest-old population (80+), data are needed that elucidate those factors associated with a successful response to the intervention. Two comparable nurse-led care programs have been evaluated in two large randomized controlled trials (RCTs), one in Switzerland and one in the Netherlands. AIMS: To identify common patient characteristics that are related to a successful response to proactive nurse-led care, we explored if and to what extent, identical factors were present in both study populations...
June 2017: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/28632340/prescribing-in-the-oldest-old-inpatients-a-retrospective-analysis-of-patients-referred-for-specialist-geriatric-consultation
#16
Sivarajah Ilango, Peter Pillans, Nancye M Peel, Ian Scott, Leonard C Gray, Ruth E Hubbard
INTRODUCTION: While medications may prolong life and prevent morbidity in older people, adverse effects of polypharmacy are increasingly recognised. As patients age and become frail, prescribing may be expected to focus more on symptom control and minimise potentially harmful preventive medication use that confer little benefit within a short lifespan. Whether prescribing practice shifts to one of symptom control among the oldest old admitted to hospital remains unclear. METHODS: Retrospective analysis of all patients aged ≥85 years referred for comprehensive geriatric assessment at a tertiary care hospital between May 2006 and December 2014 for whom all prescribed medications were documented...
June 20, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28629899/high-adherence-to-a-mediterranean-diet-and-lower-risk-of-frailty-among-french-older-adults-community-dwellers-results-from-the-three-city-bordeaux-study
#17
Berna Rahi, Soufiane Ajana, Maturin Tabue-Teguo, Jean-François Dartigues, Karine Peres, Catherine Feart
BACKGROUND & AIMS: Mediterranean diet (MeDi) is considered as a key component for healthy aging, including prevention of age-related disability, while its association with frailty, independent of disability has never been assessed. Our objective was to investigate the relation between MeDi adherence and frailty incidence among persons aged ≥75 years participating at the prospective population-based French Three-City Study. METHODS: The study sample consisted of 560 initially non-frail participants of the Three-City-Bordeaux center, seen at the 2009-2010 follow-up, and re-examined two years later...
May 31, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28628498/earlier-physical-therapy-input-is-associated-with-a-reduced-length-of-hospital-stay-and-reduced-care-needs-on-discharge-in-frail-older-inpatients-an-observational-study
#18
Peter J Hartley, Victoria L Keevil, Ledia Alushi, Rebecca L Charles, Eimear B Conroy, Patricia M Costello, Becki Dixon, Aida M Dolinska-Grzybek, Diana Vajda, Roman Romero-Ortuno
BACKGROUND AND PURPOSE: Pressures on hospital bed occupancy in the English National Health Service have focused attention on enhanced service delivery models and methods by which physical therapists might contribute to effective cost savings, while retaining a patient-centered approach. Earlier access to physical therapy may lead to better outcomes in frail older inpatients, but this has not been well studied in acute National Health Service hospitals. Our aim was to retrospectively study the associations between early physical therapy input and length of hospital stay (LOS), functional outcomes, and care needs on discharge...
June 16, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/28627050/effects-of-a-community-disability-prevention-program-for-frail-older-adults-at-48-month-follow-up
#19
Hyuma Makizako, Hiroyuki Shimada, Takehiko Doi, Kota Tsutumimoto, Daisuke Yoshida, Takao Suzuki
AIM: The present prospective study was carried out to determine whether participation in community-based intervention studies exerted a positive impact on disability prevention in older adults with physical frailty. METHODS: A total of 514 community-dwelling older adults (aged ≥65 years) with physical frailty who had undergone baseline assessment and participated in community-based intervention studies (participants) or did not (non-participants) were included in the present study...
June 18, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28621000/how-serious-is-bias-in-effect-estimation-in-randomised-trials-with-survival-data-given-risk-heterogeneity-and-informative-censoring
#20
Roseanne McNamee
It is often assumed that randomisation will prevent bias in estimation of treatment effects from clinical trials, but this is not true of the semiparametric Proportional Hazards model for survival data when there is underlying risk heterogeneity. Here, a new formula is proposed for estimation of this bias, improving on a previous formula through ease of use and clarity regarding the role of the mid-study cumulative hazard rate, shown to be an important factor for the bias magnitude. Informative censoring (IC) is recognised as a source of bias...
June 15, 2017: Statistics in Medicine
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