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frailty prevention

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https://www.readbyqxmd.com/read/28091981/environmental-pollutants-limitations-in-physical-functioning-and-frailty-in-older-adults
#1
REVIEW
Esther García-Esquinas, Fernando Rodríguez-Artalejo
PURPOSE OF REVIEW: Frailty is an age-related syndrome characterized by reductions in strength, endurance, and physiologic function that increase an individual's vulnerability for developing dependence or death. Extensive research is currently being conducted to determine preventable risk factors and mechanistic pathways of frailty. This review summarizes the existing evidence on the potential associations between environmental pollutants, limitations in physical functioning, and frailty among older adults...
January 16, 2017: Current Environmental Health Reports
https://www.readbyqxmd.com/read/28077832/-frailty-and-its-related-factors-in-vulnerable-elderly-population-by-age-groups
#2
Eunok Park, Mi Yu
PURPOSE: This study aimed to investigate factors affecting frailty by age groups among vulnerable elders in Korea. METHODS: In this secondary analysis, data were collected from records for 22,868 eldesr registered in the Visiting Health Management program of Publci Health Centers in 2012. Health behaviors, clinically diagnosed disease, frailty, depression and cognitive condition were assessed. Data were analyzed using stepwise regression to determine the associated factors of frailty by age group...
December 2016: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/28076861/potential-applications-of-smart-multifunctional-wearable-materials-to-gerontology
#3
David G Armstrong, Bijan Najafi, Mohsen Shahinpoor
Smart multifunctional materials can play a constructive role in addressing some very important aging-related issues. Aging affects the ability of older adults to continue to live safely and economically in their own residences for as long as possible. Thus, there will be a greater need for preventive, acute, rehabilitative, and long-term health care services for older adults as well as a need for tools to enable them to function independently during daily activities. The objective of this paper is, thus, to present a comprehensive review of some potential smart materials and their areas of applications to gerontology...
January 12, 2017: Gerontology
https://www.readbyqxmd.com/read/28064173/interventions-to-prevent-or-reduce-the-level-of-frailty-in-community-dwelling-older-adults-a-scoping-review-of-the-literature-and-international-policies
#4
REVIEW
Martine T E Puts, Samar Toubasi, Melissa K Andrew, Maureen C Ashe, Jenny Ploeg, Esther Atkinson, Ana Patricia Ayala, Angelique Roy, Miriam Rodríguez Monforte, Howard Bergman, Kathy McGilton
BACKGROUND: frailty impacts older adults' ability to recover from an acute illness, injuries and other stresses. Currently, a systematic synthesis of available interventions to prevent or reduce frailty does not exist. Therefore, we conducted a scoping review of interventions and international policies designed to prevent or reduce the level of frailty in community-dwelling older adults. METHODS AND ANALYSIS: we conducted a scoping review using the framework of Arksey and O'Malley. We systematically searched articles and grey literature to identify interventions and policies that aimed to prevent or reduce the level of frailty...
January 6, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28064172/effectiveness-of-an-intervention-to-prevent-frailty-in-pre-frail-community-dwelling-older-people-consulting-in-primary-care-a-randomised-controlled-trial
#5
M Serra-Prat, X Sist, R Domenich, L Jurado, A Saiz, A Roces, E Palomera, M Tarradelles, M Papiol
BACKGROUND: evidence on the effectiveness of interventions to prevent frailty is scarce. OBJECTIVE: to assess the effect of an intervention in preventing frailty progression in pre-frail older people. STUDY DESIGN: a randomised, open label, controlled trial with two parallel arms. POPULATION: community-dwelling pre-frail older people (≥70 years) consulting in primary care. INTERVENTION: nutritional assessment (and derivation to a Nutritional Unit for usual care in the event of nutritional risk) and a physical activity programme including aerobic exercise and a set of mixed strengthening, balance and coordination exercises CONTROL GROUP: patients receiving the usual care...
January 6, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28062832/frailty-prefrailty-and-employment-outcomes-in-health-and-employment-after-fifty-heaf-study
#6
Keith T Palmer, Stefania D'Angelo, E Clare Harris, Cathy Linaker, Catharine R Gale, Maria Evandrou, Holly Syddall, Tjeerd van Staa, Cyrus Cooper, Avan Aihie Sayer, David Coggon, Karen Walker-Bone
OBJECTIVES: Demographic changes are requiring people to work longer. No previous studies, however, have focused on whether the 'frailty' phenotype (which predicts adverse events in the elderly) is associated with employment difficulties. To provide information, we assessed associations in the Health and Employment After Fifty Study, a population-based cohort of 50-65-year olds. METHODS: Subjects, who were recruited from 24 English general practices, completed a baseline questionnaire on 'prefrailty' and 'frailty' (adapted Fried criteria) and several work outcomes, including health-related job loss (HRJL), prolonged sickness absence (>20 days vs less, past 12 months), having to cut down substantially at work and difficulty coping with work's demands...
January 6, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28035339/emerging-roles-for-histone-deacetylases-in-age-related-muscle-atrophy
#7
REVIEW
Michael E Walsh, Holly Van Remmen
BACKGROUND: Skeletal muscle atrophy during aging, a process known as sarcopenia, is associated with muscle weakness, frailty, and the loss of independence in older adults. The mechanisms contributing to sarcopenia are not totally understood, but muscle fiber loss due to apoptosis, reduced stimulation of anabolic pathways, activation of catabolic pathways, denervation, and altered metabolism have been observed in muscle from old rodents and humans. OBJECTIVE: Recently, histone deacetylases (HDACs) have been implicated in muscle atrophy and dysfunction due to denervation, muscular dystrophy, and disuse, and HDACs play key roles in regulating metabolism in skeletal muscle...
October 27, 2016: Nutr Healthy Aging
https://www.readbyqxmd.com/read/28034376/predictors-and-prognostic-implications-of%C3%A2-incident-heart-failure-in-patients-with%C3%A2-prevalent-atrial-fibrillation
#8
Ambarish Pandey, Sunghee Kim, Curtiss Moore, Laine Thomas, Bernard Gersh, Larry A Allen, Peter R Kowey, Kenneth W Mahaffey, Elaine Hylek, Eric D Peterson, Jonathan P Piccini, Gregg C Fonarow
OBJECTIVES: The purpose of this study was to determine the significant clinical predictors of incident heart failure (HF) and its prognostic effect on long-term outcomes among community-based patients with established atrial fibrillation (AF). BACKGROUND: AF is associated with an increased risk of HF. However, in this population, little focus is placed on risk stratification for and the prevention of HF. METHODS: Patients with AF but without HF at baseline enrolled in the ORBIT-AF (Outcomes Registry for Informed Treatment of Atrial Fibrillation) registry were included...
January 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28024089/is-polypharmacy-associated-with-frailty-in-older-people-results-from-the-esther-cohort-study
#9
Kai-Uwe Saum, Ben Schöttker, Andreas D Meid, Bernd Holleczek, Walter E Haefeli, Klaus Hauer, Hermann Brenner
OBJECTIVES: To investigate the relationship between polypharmacy and frailty. DESIGN: Longitudinal, observational cohort study. SETTING: Saarland, Germany. PARTICIPANTS: 3,058 community-dwelling adults aged between 57 and 84 years. MEASUREMENTS: Frailty was assessed according to the frailty phenotype, described by Fried et al. Polypharmacy and hyperpolypharmacy were defined as the concomitant use of five or more and 10 or more drugs, respectively...
December 26, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28017349/predictors-and-prognostic-implications-of-incident-heart-failure-in-patients-with-prevalent-atrial-fibrillation
#10
Ambarish Pandey, Sunghee Kim, Curtiss Moore, Laine Thomas, Bernard Gersh, Larry A Allen, Peter R Kowey, Kenneth W Mahaffey, Elaine Hylek, Eric D Peterson, Jonathan P Piccini, Gregg C Fonarow
OBJECTIVES: The purpose of this study was to determine the significant clinical predictors of incident heart failure (HF) and its prognostic effect on long-term outcomes among community-based patients with established atrial fibrillation (AF). BACKGROUND: AF is associated with an increased risk of HF. However, in this population, little focus is placed on risk stratification for and the prevention of HF. METHODS: Patients with AF but without HF at baseline enrolled in the ORBIT-AF (Outcomes Registry for Informed Treatment of Atrial Fibrillation) registry were included...
November 30, 2016: JACC. Heart Failure
https://www.readbyqxmd.com/read/28001461/tobacco-smoking-and-smoking-related-dna-methylation-are-associated-with-the-development-of-frailty-among-older-adults
#11
Xu Gao, Yan Zhang, Kai-Uwe Saum, Ben Schöttker, Lutz Philipp Breitling, Hermann Brenner
Tobacco smoking is a preventable environmental factor that contributes to a wide spectrum of age-related health outcomes; however, its association with the development of frailty is not yet well established. We examined the associations of self-reported smoking indicators, serum cotinine levels and smoking-related DNA methylation biomarkers with a quantitative frailty index (FI) in two independent subsets of older adults (age 50-75) recruited in Saarland, Germany in 2000 - 2002 (discovery set: n = 978, validation set: n = 531)...
December 21, 2016: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/27999225/passi-d-argento-silver-steps-the-main-features-of-the-new-nationwide-surveillance-system-for-the-ageing-italian-population-italy-2013-2014
#12
Benedetta Contoli, Patrizia Carrieri, Maria Masocco, Luana Penna, Alberto Perra
BACKGROUND: Italy is particularly concerned by population ageing. The costs for society are substantial. In this context a national, representative surveillance system, Passi D'Argento (PDA), was implemented in 2009 to monitor "active aging" and health status in people aged over 64 and to develop preventive health programs to reduce frailty. METHODS/DESIGN: PDA recruited a representative sample of 24 129 individuals (March 2012-January 2013) aged over 64 who were interviewed by trained staff using a standardized questionnaire...
October 2016: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/27996360/liver-transplantation-for-hepatocellular-carcinoma-in-young-adults-a-united-network-for-organ-sharing-study
#13
Stefanie M Thomas, Diana Moke, Rocio Lopez, Rabi Hanna, Mohammad Nasser Kabbany, Naim Alkhouri
PURPOSE: Orthotopic liver transplantation (OLT) is curative for hepatocellular carcinoma (HCC). HCC is typically a disease of older adults (OAs); therefore, characteristics and outcomes of OLT for young adults (YAs) (ages 18-40) are not described. The objective of this study was to assess the characteristics and outcomes of YAs with HCC receiving OLT and compare these to OAs (ages >40 years). METHODS: YAs with HCC who had OLT from the United Network for Organ Sharing (UNOS) database were included in this study...
December 20, 2016: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/27959941/impact-of-oral-treatment-on-physical-function-in-older-patients-hospitalized-for-heart-failure-a-randomized-clinical-trial
#14
Kazutaka Ueda, Masashi Kasao, Motoaki Shimamura, Hironori Haruta, Shuya Nitta, Mitsunobu Kaneko, Yukari Uemura, Hiroyuki Morita, Issei Komuro, Tetsuro Shirai
BACKGROUND: Frailty is a characteristic of older patients with heart failure, who undergo functional decline during hospitalization. At present, continuous intravenous infusion of diuretics is widely used for the treatment of hospitalized patients with heart failure. In this prospective, randomized, open-label controlled trial, we tested whether an early switch from continuous intravenous infusion therapy to oral treatment with diuretics prevents functional decline in patients hospitalized for heart failure...
2016: PloS One
https://www.readbyqxmd.com/read/27942948/potentially-inappropriate-prescribing-in-a-population-of-frail-elderly-people
#15
Isabelle Récoché, Cécile Lebaudy, Charlène Cool, Sandrine Sourdet, Antoine Piau, Maryse Lapeyre-Mestre, Bruno Vellas, Philippe Cestac
Background Frailty is a clinical syndrome highly predictive of functional decline after a stress or a medical event, such as adverse drug events. Objective To describe the prevalence of potentially inappropriate prescribing in a population of frail elderly patients. Setting Geriatric day hospital for assessment of frailty and prevention of disability, Toulouse, France. Method A cross-sectional study performed from January to April 2014. Two pharmacists retrospectively analyzed the prescriptions of elderly patients who were sent to the day hospital to assess their frailty and to be given a personalized plan of care and prevention...
December 10, 2016: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/27932368/longitudinal-associations-between-body-composition-sarcopenic-obesity-and-outcomes-of-frailty-disability-institutionalisation-and-mortality-in-community-dwelling-older-men-the-concord-health-and-ageing-in-men-project
#16
Vasant Hirani, Vasi Naganathan, Fiona Blyth, David G Le Couteur, Markus J Seibel, Louise M Waite, David J Handelsman, Robert G Cumming
BACKGROUND: to explore the longitudinal associations between body composition measures, sarcopenic obesity and outcomes of frailty, activities of daily living (ADL) and instrumental ADL (IADL) disability, institutionalisation and mortality. METHODS: men aged ≥ 70 years (2005-07) from the Concord Health and Ageing in Men Project were assessed at baseline (n = 1,705), 2 (n = 1,366) and 5 years (n = 954). The main outcome measures were frailty (adapted Fried criteria), ADL, including personal care and mobility and IADL disability (ability to perform tasks for independent living), institutionalisation and mortality...
December 7, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27923981/sarcopenia-and-frailty-in-chronic-respiratory-disease-lessons-from-gerontology
#17
Anna E Bone, Nilay Hepgul, Samantha Kon, Matthew Maddocks
Sarcopenia and frailty are geriatric syndromes characterized by multisystem decline, which are related to and reflected by markers of skeletal muscle dysfunction. In older people, sarcopenia and frailty have been used for risk stratification, to predict adverse outcomes and to prompt intervention aimed at preventing decline in those at greatest risk. In this review, we examine sarcopenia and frailty in the context of chronic respiratory disease, providing an overview of the common assessments tools and studies to date in the field...
December 6, 2016: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/27919145/-development-of-a-predictive-model-of-death-or-urgent-hospitalization-to-identify-frail-elderly
#18
Paolo Pandolfi, Natalina Collina, Paolo Marzaroli, Elisa Stivanello, Muriel Assunta Musti, Chiara Giansante, Vincenza Perlangeli, Lorenzo Pizzi, Sara De Lisio, Fausto Francia
OBJECTIVES: to develop and validate a predictive model of mortality or emergency hospitalization in all subjects aged 65 years and over. DESIGN: cohort study based on 9 different databases linked with each other. SETTING AND PARTICIPANTS: the model was developed on the population aged 65 years and over resident at 01.01.2011 for at least two years in the city of Bologna (Emilia-Romagna Region, Northern Italy); 96,000 persons were included...
November 2016: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/27913742/frailty-assessment-in-hospitalized-older-adults-using-the-electronic-health-record
#19
Deborah A Lekan, Debra C Wallace, Thomas P McCoy, Jie Hu, Susan G Silva, Heather E Whitson
INTRODUCTION: Frailty, a clinical syndrome of decreased physiologic reserve and dysregulation in multiple physiologic systems, is associated with increased risk for adverse outcomes. PURPOSE: The aim of this retrospective, cross-sectional, correlational study was to characterize frailty in older adults admitted to a tertiary-care hospital using a biopsychosocial frailty assessment and to determine associations between frailty and time to in-hospital mortality and 30-day rehospitalization...
December 2, 2016: Biological Research for Nursing
https://www.readbyqxmd.com/read/27904019/clinical-characteristics-and-social-frailty-of-super-elderly-patients-with-heart-failure%C3%A3-the-kitakawachi-clinical-background-and-outcome-of-heart-failure-registry
#20
Kensuke Takabayashi, Akihiro Ikuta, Yoshinori Okazaki, Mariko Ogami, Kotaro Iwatsu, Koichi Matsumura, Tsutomu Ikeda, Tahei Ichinohe, Yuko Morikami, Takashi Yamamoto, Ryoko Fujita, Kotoe Takenaka, Hiroyuki Takenaka, Yoshisumi Haruna, Hiroyuki Muranaka, Masaaki Ozaki, Tetsuhisa Kitamura, Shouji Kitaguchi, Ryuji Nohara
BACKGROUND: Social background is important in preventing admission/readmission of heart failure (HF) patients. However, few clinical studies have been conducted to assess the social background of these patients, especially elderly patients.Methods and Results:The Kitakawachi Clinical Background and Outcome of Heart Failure (KICKOFF) Registry is a prospective multicenter community-based cohort of HF patients, established in April 2015. We compared the clinical characteristics and social background of the super-elderly group (≥85 years old) and the non-super-elderly group (<85 years old)...
December 22, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
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