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frailty prevention

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https://www.readbyqxmd.com/read/29346524/-effects-of-a-primary-care-based-multifactorial-intervention-on-physical-and-cognitive-function-in-frail-elderly-individuals-a-randomized-controlled-trial
#1
Laura Romera-Liebana, Francesc Orfila, Josep Maria Segura, Jordi Real, Maria Lluïsa Fabra, Mercedes Möller, Santiago Lancho, Anna Ramirez, Nuria Marti, Montserrat Cullell, Nuria Bastida, Dolors Martinez, Maria Giné, Patricia Cendrós, Anna Bistuer, Elena Perez, Maria Assumpta Fabregat, Gonçal Foz
Background: Detecting and managing frailty at early stages can prevent disability and other adverse outcomes. The study aim was to evaluate whether a multifactorial intervention program could modify physical and cognitive frailty parameters in elderly individuals. Methods: We conducted a multicenter, randomized, single-blind, parallel-group trial in community-living pre-frail/frail elderly individuals in Barcelona. A total of 352 patients, aged ≥65 years old with positive frailty screening, was randomized into two groups to receive a 12-week multidisciplinary intervention or usual care, with concealed allocation...
January 16, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29346256/causes-preventability-and-cost-of-unplanned-rehospitalizations-within-30-days-of-discharge-following-lung-transplantation
#2
Andrew M Courtwright, Derek Zaleski, Lisa Gardo, Vivek N Ahya, Jason D Christie, Maria Crespo, Denis Hadjiliadis, James Lee, Maria Molina, Namrata Patel, Mary Porteous, Edward E Cantu, Christian Bermudez, Joshua M Diamond
BACKGROUND: Unplanned rehospitalizations (UR) within 30 days of discharge are common following lung transplantation. It is unknown whether UR represent preventable gaps in care or necessary interventions for complex patients. The objective of this study was to assess the incidence, causes, risk factors, and preventability of UR following initial discharge after lung transplantation. METHODS: This was a single-center prospective cohort study. Subjects completed a modified Short Physical Performance Battery (SPPB) to assess frailty at listing and at initial hospital discharge after transplantation and the State-Trait Anxiety Inventory (STAI) at discharge...
January 18, 2018: Transplantation
https://www.readbyqxmd.com/read/29338602/sequential-drug-treatment-algorithm-for-agitation-and-aggression-in-alzheimer-s-and-mixed-dementia
#3
Simon Jc Davies, Amer M Burhan, Donna Kim, Philip Gerretsen, Ariel Graff-Guerrero, Vincent L Woo, Sanjeev Kumar, Sarah Colman, Bruce G Pollock, Benoit H Mulsant, Tarek K Rajji
INTRODUCTION: Behavioural and psychological symptoms of dementia (BPSD) include agitation and aggression in people with dementia. BPSD is common on inpatient psychogeriatric units and may prevent individuals from living at home or in residential/nursing home settings. Several drugs and non-pharmacological treatments have been shown to be effective in reducing behavioural and psychological symptoms of dementia. Algorithmic treatment may address the challenge of synthesizing this evidence-based knowledge...
January 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29328899/preventing-cardiovascular-disease-in-older-adults-one-size-does-not-fit-all
#4
REVIEW
Ariela R Orkaby, Oyere Onuma, Saadia Qazi, J Michael Gaziano, Jane A Driver
Frailty and cardiovascular disease are highly interconnected and increase in prevalence with age. Identifying frailty allows for a personalized cardiovascular risk prescription and individualized management of hypertension, hyperlipidemia, diabetes, and lifestyle in the aging population.
January 2018: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/29325443/moving-upstream-in-health-promoting-policies-for-older-people-with-early-frailty-in-england-a-policy-analysis
#5
Vari Drennan, Kate Walters, Christina Avgerinou, Benjamin Gardner, Claire Goodman, Rachael Frost, Kalpa Kharicha, Steve Iliffe, Jill Manthorpe
Objectives Globally, populations are rapidly ageing and countries have developed health promotion and wellbeing strategies to address increasing demand for health care and old-age support. The older population is not homogeneous however, and includes a large group in transition between being active and healthy to being frail, i.e. with early frailty. This review explores the extent to which policy in England has addressed this group with a view to supporting independence and preventing further progression towards frailty...
January 1, 2018: Journal of Health Services Research & Policy
https://www.readbyqxmd.com/read/29324562/effectiveness-of-interventions-to-prevent-pre-frailty-and-frailty-progression-in-older-adults-a-systematic-review
#6
João Apóstolo, Richard Cooke, Elzbieta Bobrowicz-Campos, Silvina Santana, Maura Marcucci, Antonio Cano, Miriam Vollenbroek-Hutten, Federico Germini, Barbara D'Avanzo, Holly Gwyther, Carol Holland
OBJECTIVE: To summarize the best available evidence regarding the effectiveness of interventions for preventing frailty progression in older adults. INTRODUCTION: Frailty is an age-related state of decreased physiological reserves characterized by an increased risk of poor clinical outcomes. Evidence supporting the malleability of frailty, its prevention and treatment, has been presented. INCLUSION CRITERIA: The review considered studies on older adults aged 65 and over, explicitly identified as pre-frail or frail, who had been undergoing interventions focusing on the prevention of frailty progression...
January 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29316345/factors-related-to-frailty-among-the-elderly-in-south-korea-a-3-year-longitudinal-study
#7
Jin-Kyoung Park, Jong-Eun Lee
PURPOSE: To examine factors associated with frailty among the young-old elderly (YOE) and old-old elderly (OOE). METHODS: This longitudinal study with a 3-year follow-up included 486 participants who received home care services. FINDINGS: Precipitous weight loss and depression in the YOE and worsening of complex mobility and depression in the OOE were associated with worsened frailty over the 3-year period. CONCLUSIONS: To prevent frailty, we suggest weight-loss prevention programs for the YOE, lower-limb exercise programs for the OOE, and depression management programs for both groups...
January 5, 2018: International Journal of Nursing Knowledge
https://www.readbyqxmd.com/read/29314622/frailty-prevalence-in-australia-findings-from-four-pooled-australian-cohort-studies
#8
Mark Q Thompson, Olga Theou, Jonathon Karnon, Robert J Adams, Renuka Visvanathan
OBJECTIVE: To examine frailty prevalence in Australian older adults. METHODS: Frailty was measured using a modified Fried Frailty Phenotype (FFP) in a combined cohort of 8804 Australian adults aged ≥65 years (female 86%, median age 80 (79-82) years) from the Dynamic Analyses to Optimise Ageing Project and the North West Adelaide Health Study. RESULTS: Using the FFP, 21% of participants were frail while a further 48% were prefrail. Chi-squared testing of frailty among four age groups (65-69, 70-74, 75-79 and 80-84 years) for sex, and marital status revealed that frailty was significantly higher for women (approximately double that of men), increased significantly with advancing age for both sexes, and was significantly higher for women who were widowed, divorced or never married...
January 5, 2018: Australasian Journal on Ageing
https://www.readbyqxmd.com/read/29300416/the-association-between-bmi-and-different-frailty-domains-a-u-shaped-curve
#9
M L Rietman, D L van der A, S H van Oostrom, H S J Picavet, M E T Dollé, H van Steeg, W M M Verschuren, A M W Spijkerman
OBJECTIVES: Previous studies showed a U-shaped association between BMI and (physical) frailty. We studied the association between BMI and physical, cognitive, psychological, and social frailty. Furthermore, the overlap between and prevalence of these frailty domains was examined. DESIGN: Cross-sectional study. SETTING: The Doetinchem Cohort Study is a longitudinal population-based study starting in 1987-1991 examining men and women aged 20-59 with follow-up examinations every 5 yrs...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29296872/chronic-disease-burden-and-frailty-in-survivors-of-childhood-hsct-a-report-from-the-st-jude-lifetime-cohort-study
#10
Hesham M Eissa, Lu Lu, Malek Baassiri, Nickhill Bhakta, Matthew J Ehrhardt, Brandon M Triplett, Daniel M Green, Daniel A Mulrooney, Leslie L Robison, Melissa M Hudson, Kirsten K Ness
Outcomes of hematopoietic stem cell transplantation (HSCT) have markedly improved over the past 2 decades, underscoring a need to better understand the long-term health effects of this intensive treatment modality. We describe the burden of chronic medical conditions and frail health among St. Jude Lifetime Cohort Study participants treated for childhood hematologic malignancies with HSCT (n = 112) or with conventional therapy (n = 1106). Chronic conditions and frail health were ascertained clinically and classified according to a modified version of the Common Terminology Criteria for Adverse Events (version 4...
November 14, 2017: Blood Advances
https://www.readbyqxmd.com/read/29289542/adherence-to-mediterranean-diet-and-frailty
#11
Eva Ntanasi, Mary Yannakoulia, Mary-Helen Kosmidis, Costas A Anastasiou, Efthimios Dardiotis, Giorgos Hadjigeorgiou, Paraskevi Sakka, Nikolaos Scarmeas
OBJECTIVE: Το investigate associations between adherence to the Mediterranean diet and frailty in a Greek population of older adults. DESIGN: Cross-sectional study. SETTING: Data were drawn from the Hellenic longitudinal Investigation of Aging and Diet (HELIAD), a population-based, multidisciplinary study designed to estimate the prevalence and incidence of dementia in the Greek population. PARTICIPANTS: Data from 1740 participants aged ≥65 years were included in the present analysis...
December 27, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29282270/frailty-measurement-and-outcomes-in-interventional-studies-protocol-for-a-systematic-review-of-randomised-control-trials
#12
Melissa Shears, Danielle McGolrick, Braden Waters, Marnie Jakab, J Gordon Boyd, John Muscedere
INTRODUCTION: Frailty is associated with reduced functional capacity, decreased resistance to stressors and is predictive of a range of adverse health outcomes, including dependency, hospitalisation and mortality. Early identification of frailty may prevent, reduce and postpone adverse health outcomes. However, there is a need for additional evidence to guide decision-making for the care of frail patients since frail persons are frequently excluded from studies, the differential impact of frailty is often not examined in clinical trials and few large-scale clinical trials examining frail cohorts have been conducted...
December 26, 2017: BMJ Open
https://www.readbyqxmd.com/read/29282000/the-association-between-anemia-and-falls-in-community-living-women-and-men-aged-65-years-and-older-from-the-fifth-troms%C3%A3-study-2001-02-a-replication-study
#13
Laila Arnesdatter Hopstock, Elisabeth Bøe Utne, Alexander Horsch, Tove Skjelbakken
BACKGROUND: Falls are common among elderly people, and the risk increase with age. Falls are associated with both health and social consequences for the patient, and major societal costs. Identification of risk factors should be investigated to prevent falls. Previous studies have shown anemia to be associated with increased risk of falling, but the results are inconsistent. The aim of this study was to investigate the association between anemia and self-reported falls among community-living elderly people...
December 27, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29238176/emotion-experience-and-frailty-in-a-sample-of-italian-community-dwelling-older-adults
#14
Anna Mulasso, Laura Argiolu, Mattia Roppolo, Danny Azucar, Emanuela Rabaglietti
Frailty increases individual vulnerability to external stressors and involves high risk for adverse geriatric outcomes. To date, few studies have addressed the role of emotion perception and its association with frailty in aged populations. This cross-sectional study aimed to explore whether a significant association between frailty and emotional experience exists in a sample of Italian community-dwelling older adults. Our sample consisted of 104 older adults (age 76±8 years; 59.6% women) living in Piedmont, Italy...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29238004/frailty-in-elderly-diabetes-patients
#15
Toshihiko Yanase, Ikumi Yanagita, Kazuo Muta, Hajime Nawata
Frailty is a state of vulnerability and a consequence of cumulative decline in multiple physiological systems over a lifespan. The occurrence of frailty depends on deterioration in muscle and nerve function, declining cardiopulmonary reserve and loss of executive function. Diabetes mellitus (DM) often causes functional impairment in each of the above systems, thus leading to a loss of whole body homeostasis and deterioration in physical function. Inability of self-management in DM patients may also have considerable impact on the development of sarcopenia/frailty...
December 14, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29236162/bisphosphonates-prevent-age-related-weight-loss-in-japanese-postmenopausal-women
#16
Tomohiko Urano, Masataka Shiraki, Tatsuhiko Kuroda, Shiro Tanaka, Fumihiko Urano, Kazuhiro Uenishi, Satoshi Inoue
Decline of body weight with aging is a major risk factor for frailty, osteoporosis and fracture, suggesting that treatment for osteoporosis may affect body composition. Recently, we have shown that 5-year treatment with raloxifene prevented age-related weight loss, suggesting some other drugs for osteoporosis may also prevent a decrease in body weight with aging. The present study aimed to identify the relationship between bisphosphonate treatment and body composition markers. We measured bone mineral density (BMD), body composition, and bone remodeling markers in 551 Japanese postmenopausal women with bisphosphonate treatment, which included risedronate or alendronate treatment (BP-treatment group; N = 193) and without treatment by any osteoporosis drug (no-treatment group; N = 358) for 4-7 years (mean observation periods; 5...
December 13, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29224700/preventing-weakness-and-stiffness-a-top-priority-for-health-and-social-care
#17
REVIEW
Muir Gray, Kenny Butler
With growing evidence that sarcopenia, disability and frailty can be prevented with physical activity, people living with pain, stiffness and weakness due to a musculoskeletal condition should be offered physical activity as a preventive strategy. By changing beliefs and attitudes towards ageing and raising the value and importance of physical activity, disability can be avoided or delayed and the costly burden of social care lessened. The effects of ageing and the effects of muscle strength loss are often confused...
April 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29214975/home-based-health-promotion-for-older-people-with-mild-frailty-the-homehealth-intervention-development-and-feasibility-rct
#18
Kate Walters, Rachael Frost, Kalpa Kharicha, Christina Avgerinou, Benjamin Gardner, Federico Ricciardi, Rachael Hunter, Ann Liljas, Jill Manthorpe, Vari Drennan, John Wood, Claire Goodman, Ana Jovicic, Steve Iliffe
BACKGROUND: Mild frailty or pre-frailty is common and yet is potentially reversible. Preventing progression to worsening frailty may benefit individuals and lower health/social care costs. However, we know little about effective approaches to preventing frailty progression. OBJECTIVES: (1) To develop an evidence- and theory-based home-based health promotion intervention for older people with mild frailty. (2) To assess feasibility, costs and acceptability of (i) the intervention and (ii) a full-scale clinical effectiveness and cost-effectiveness randomised controlled trial (RCT)...
December 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29210840/conoscere-e-curare-il-cuore-1986-2016-how-the-heart-has-changed
#19
Alessandro Boccanelli
: The demographic transition, with longer life expectancy, is mainly due to prevention and care of atherosclerotic vascular and heart disease. The cardiovascular patient is now much older and often presents with coexisting geriatric syndromes that affect healthcare goals, outcomes, and the process of care. Numerous mechanisms at cellular level are responsible for cardiovascular aging such as replicative senescence, apoptosis, proteins misfolding, and inflammation. Aging-related modifications are increase in left-ventricular mass, increased left atrial size, myocardial collagen deposition, and calcium deposition in valvular structures and the coronary arteries...
November 27, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29190544/the-contribution-of-occupational-factors-on-frailty
#20
REVIEW
Ivo Iavicoli, Veruscka Leso, Matteo Cesari
INTRODUCTION: Frailty is a clinical condition characterized by enhanced vulnerability to stressors and increased risk of developing dependency and/or mortality. It has been described as the multidimensional and dynamic condition that cannot be easily disentangled from psychosocial determinants. To date, the possible role of occupational factors on frailty development and its progression at advanced age are not yet fully understood. The aim of this work is to provide a comprehensive overview of existing evidence exploring the relationship between multiple occupational issues (e...
November 22, 2017: Archives of Gerontology and Geriatrics
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