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https://www.readbyqxmd.com/read/29991892/differences-in-dietary-habits-between-patients-with-inflammatory-bowel-disease-in-clinical-remission-and-a-healthy-population
#1
Mariabeatrice Principi, Giuseppe Losurdo, Andrea Iannone, Antonella Contaldo, Valentina Deflorio, Nunzio Ranaldo, Antonio Pisani, Enzo Ierardi, Alfredo Di Leo, Michele Barone
Background: Although patients with active inflammatory bowel disease (IBD) change their dietary habits according to suggestions from their healthcare team, no restriction is required in the remission phase. Accordingly, we compared eating patterns in IBD patients with drug-induced clinical remission with those in healthy subjects. Methods: A total of 150 IBD patients, 84 with Crohn's disease (CD) and 66 with ulcerative colitis (UC), in clinical remission, receiving immunomodulator/biologic therapy, and 100 healthy volunteers (controls) were enrolled...
July 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29991879/current-global-trends-in-the-incidence-of-pediatric-onset-inflammatory-bowel-disease
#2
Josef Sýkora, Renáta Pomahačová, Marcela Kreslová, Dominika Cvalínová, Přemysl Štych, Jan Schwarz
AIM: To perform a comprehensive review and provide an up-to-date synopsis of the incidence and trends of inflammatory bowel disease (IBD). METHODS: We systematically searched the MEDLINE (source PubMed), EMBASE and Cochrane Library databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (period: 1985-2018) to identify studies reporting population-based data on the incidence of pediatric-onset (< 19 years at diagnosis) IBD in full manuscripts...
July 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29987626/does-medical-acceleration-improve-outcomes-in-ulcerative-colitis-patients-who-are-in-clinical-remission-but-have-endoscopic-inflammation
#3
Ji Young Chang, Jae Hee Cheon, Yehyun Park, Soo Jung Park, Tae-Il Kim, Won-Ho Kim
BACKGROUND: Discrepancies between clinical symptoms and mucosal inflammation have been reported in up to 50% of patients with ulcerative colitis (UC). However, there are no guidelines and only limited information for appropriate treatment manipulation. AIM: We aimed to evaluate long-term outcomes according to treatment strategies and determine predictive factors for disease relapse in UC patients who are in clinical remission (CR) but still have endoscopic inflammation...
July 9, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29979218/disease-activity-steroid-use-and-extraintestinal-manifestation-are-associated-with-increased-disability-in-patients-with-inflammatory-bowel-disease-using-the-inflammatory-bowel-disease-disability-index-a-cross-sectional-multicentre-cohort-study
#4
Bobby Lo, Mette Julsgaard, Marianne Kajbæk Vester-Andersen, Ida Vind, Johan Burisch
BACKGROUND: The inflammatory bowel disease disability index (IBD-DI) was developed recently. The aim was to translate the IBD-DI into Danish and validate it for future clinical studies and practice, and to assess the level of disability among IBD patients. PATIENTS AND METHODS: The IBD-DI was translated using a transcultural adaptation method. Between January and December 2017, patients from three outpatient clinics in three different regions in Denmark were given the final version of the IBD-DI for self-completion...
July 3, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29969780/quality-of-care-in-ulcerative-colitis-a-modified-delphi-panel-approach
#5
Laurent Peyrin-Biroulet, Daniel C Baumgart, Alessandro Armuzzi, Paolo Gionchetti, Shaji Sebastian, Silvio Danese, Fernando Magro, Sophie Higgins, Andrew Yaworksy, Benjamin Banderas, Sumesh Kachroo
OBJECTIVES: To establish clinical consensus on important and relevant quality-of-care (QoC) attributes in ulcerative colitis (UC) treatment that may improve treatment outcomes and guide best practices. METHODS: Thirty-eight QoC attributes were identified in a literature review. Sixteen European-based experts were selected based on their contributions to UC guidelines, publications, and patient care. A 3-round, modified Delphi panel was conducted including an interview round, and 2 web-based rounds to reach consensus and finalize a QoC attribute list...
July 3, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29955835/safety-and-efficacy-of-ferric-carboxymaltose-in-the-treatment-of-iron-deficiency-anaemia-in-patients-with-inflammatory-bowel-disease-in-routine-daily-practice
#6
Jürgen Stein, Aysegül Aksan, Wolfgang Klemm, Kerry Nip, Susanne Weber-Mangal, Axel Dignass
Introduction: Iron deficiency and iron deficiency anaemia are common complications in inflammatory bowel disease [IBD] patients. Anaemia in IBD is attributable to chronic blood loss and/or impaired iron intake and absorption. International guidelines recommend intravenous iron supplementation in IBD patients, since oral supplements are frequently poorly tolerated and can exacerbate inflammation. Intravenous ferric carboxymaltose [FCM; Ferinject® 50 mg ferric iron[III]/mL suspension] was approved in Europe in 2007 for correction of iron deficiency, and can be administered in single 15-min infusions of up to 1000 mg...
June 28, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29902246/validated-uplc-ms-ms-method-for-the-quantification-of-dasatinib-in-plasma-application-to-pharmacokinetic-interaction-studies-with-nutraceuticals-in-wistar-rats
#7
Hadir M Maher, Nourah Z Alzoman, Shereen M Shehata, Norah O Abanmy
Dasatinib (DAS) is a tyrosine kinase inhibitor (TKI) used in the treatment of chronic myeloid leukemia and in the management of ulcerative colitis (UC). Since some nutraceuticals (e.g. curcumin, olive oil, and cocoa extract) could alter the function of ABC transporters and /or CYP450 enzymes, DAS bioavailability could potentially be affected following their co-administration. This work aims at studying the possibility of PK interaction between DAS and the selected nutraceuticals in UC rats using UPLC- MS/MS...
2018: PloS One
https://www.readbyqxmd.com/read/29872891/-inflammatory-bowel-diseases-crohn-s-disease-and-ulcerative-colitis
#8
S Fischer, T Rath, M F Neurath
Inflammatory bowel diseases (IBD) are complex diseases. Epidemiological studies suggest rising incidences in industrialized countries. The article is based on a literature search in PubMed and is oriented on the current guidelines published by the European Crohn's and Colitis Organisation. IBD are characterized by chronic diarrhoea, abdominal pain and peranal haemorrhage. Extraintestinal manifestations commonly affect joints, skin, eyes and bile tracts. Early diagnosis and therapeutic intervention determine individual patient outcome...
June 5, 2018: Der Internist
https://www.readbyqxmd.com/read/29851767/management-of-paediatric-ulcerative-colitis-part-2-acute-severe-colitis-an-evidence-based-consensus-guideline-from-ecco-and-espghan
#9
Dan Turner, Frank M Ruemmele, Esther Orlanski-Meyer, Anne M Griffiths, Javier Martin de Carpi, Jiri Bronsky, Gabor Veres, Marina Aloi, Caterina Strisciuglio, Christian P Braegger, Amit Assa, Claudio Romano, Séamus Hussey, Michael Stanton, Mikko Pakarinen, Lissy de Ridder, Konstantinos H Katsanos, Nick Croft, Víctor Manuel Navas-López, David C Wilson, Sally Lawrence, Richard K Russell
BACKGROUND AND AIM: Acute severe colitis (ASC) is one of the few emergencies in paediatric gastroenterology. Tight monitoring and timely medical and surgical interventions may improve outcomes and minimize morbidity and mortality. We aimed to standardize daily treatment of ASC in children through detailed recommendations and practice points which are based on a systematic review of the literature and consensus of experts. METHODS: These guidelines are a joint effort of the European Crohn's and Colitis Organization (ECCO) and the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN)...
May 30, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29851766/management-of-paediatric-ulcerative-colitis-part-1-ambulatory-care-an-evidence-based-guideline-from-ecco-and-espghan
#10
Dan Turner, Frank M Ruemmele, Esther Orlanski-Meyer, Anne M Griffiths, Javier Martin de Carpi, Jiri Bronsky, Gabor Veres, Marina Aloi, Caterina Strisciuglio, Christian P Braegger, Amit Assa, Claudio Romano, Séamus Hussey, Michael Stanton, Mikko Pakarinen, Lissy de Ridder, Konstantinos Katsanos, Nick Croft, Victor Navas-López, David C Wilson, Sally Lawrence, Richard K Russell
BACKGROUND: The contemporary management of ambulatory ulcerative colitis (UC) continues to be challenging with ∼20% of children needing a colectomy within childhood years. We thus aimed to standardize daily treatment of paediatric UC and inflammatory bowel diseases (IBD)-unclassified through detailed recommendations and practice points. METHODS: These guidelines are a joint effort of the European Crohn's and Colitis Organization (ECCO) and the Paediatric IBD Porto group of European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN)...
May 30, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29805360/neoterminal-ileal-polyposis-and-ulceration-after-restorative-proctocolectomy-with-a-current-review-of-the-literature
#11
Venkata Subhash Gorrepati, Negar Rassaei, Kofi Clarke
After ileal pouch anal anastomosis, one of the frequently encountered complications is polyposis of the pouch. We describe a case of proximal neoterminal ileal polyposis associated with deep ulceration suggestive of Crohn's disease and review the available literature. A 36-year-old male presented with resistant pouchitis 11 years after surgery for ulcerative colitis. With all-negative initial workup, pouchoscopy showed multiple deep ulcers in the proximal ileum with some polyps. Biopsy of polyps showed inflammatory polyps with negative immunohistological staining for IgG pouchitis...
January 2018: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29788127/herpes-zoster-in-patients-receiving-jak-inhibitors-for-ulcerative-colitis-mechanism-epidemiology-management-and-prevention
#12
Jean-Frédéric Colombel
Increased risk of herpes zoster (HZ) has been observed in patients with immune-mediated diseases, including rheumatoid arthritis (RA), psoriasis (PsO), and inflammatory bowel disease; this risk can be further increased by the use of immunosuppressive therapy. One advancing modality of therapy for these diseases is Janus kinase (JAK) inhibition. Tofacitinib is an oral JAK inhibitor for the treatment of RA and psoriatic arthritis, which is currently under investigation for the treatment of ulcerative colitis (UC) and was previously investigated for psoriasis...
May 17, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29781837/short-article-recommendations-on-rectal-surveillance-for-colorectal-cancer-after-subtotal-colectomy-in-patients-with-inflammatory-bowel-disease
#13
Lauranne A A P Derikx, Michiel E de Jong, Frank Hoentjen
Approximately 30% of patients with ulcerative colitis require a colectomy during their disease course. This substantially reduces colorectal cancer risk, although it is still possible to develop colorectal neoplasia in the remaining rectum. Although clear and well-accepted surveillance guidelines exist for patients with inflammatory bowel disease with an intact colon, specific surveillance recommendations following colectomy are less clear. Here, we aim to summarize the prevalence, incidence, and risk factors for developing colorectal cancer in patients with inflammatory bowel disease who underwent subtotal colectomy with a permanent end ileostomy and rectal stump, or with ileorectal anastomosis...
August 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29771698/updates-in-colorectal-cancer-screening-in-inflammatory-bowel-disease
#14
William T Clarke, Joseph D Feuerstein
PURPOSE OF REVIEW: This review article will discuss the risk of colorectal cancer (CRC) in patients with inflammatory bowel disease (IBD), as well as the current recommendations for CRC screening and surveillance in patients with ulcerative colitis or Crohn's colitis involving one-third of the colon. RECENT FINDINGS: Given that most cases of CRC are thought to arise from dysplasia, previous guidelines have recommended endoscopic surveillance with random biopsies obtained from all segments of the colon...
July 2018: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/29768701/management-of-early-pouch-related-septic-complications-in-ulcerative-colitis-a-systematic-review
#15
REVIEW
G H T Worley, J P Segal, J Warusavitarne, S K Clark, O D Faiz
AIM: It is well established that ileo-anal pouch-related septic complications (PRSC) increase the risk of pouch failure. There are a number of publications that describe the management of early PRSC in ulcerative colitis (UC) in small series. This article aims to systematically review and summarize the relevant current data on this subject and provide an algorithm for the management of early PRSC. METHOD: A systematic review was undertaken in accordance with PRISMA guidelines...
May 16, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29764306/long-term-complications-of-appendectomy-a-systematic-review
#16
T Rasmussen, S Fonnes, J Rosenberg
BACKGROUND AND AIMS: Appendectomy is a common surgical procedure, but no overview of the long-term consequences exists. Our aim was to systematically review the long-term complications of appendectomy for acute appendicitis. MATERIALS AND METHODS: This systematic review was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A protocol was registered on PROSPERO (CRD42017064662). The databases PubMed and EMBASE were searched for original reports on appendectomy with n ≥ 500 and follow-up >30 days...
May 1, 2018: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/29750050/does-the-internet-promote-the-unregulated-use-of-fecal-microbiota-transplantation-a-potential-public-health-issue
#17
Jonathan Philip Segal, Faisal Abbasi, Cynthia Kanagasundaram, Ailsa Hart
Introduction: The Internet has become an increasingly popular resource for medical information. Fecal microbiota transplantation (FMT) has changed the treatment of Clostridium difficile with cure rates of 81% following one infusion of FMT, further studies have since validated these findings. The Medicines and Health care Products Regulatory Agency has classified FMT as a medicine and hence should be only utilized in strict clinical settings. Methods: We searched Facebook, Twitter, Google, and YouTube using the words "Faecal Microbiota Transplantation" and "FMT"...
2018: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/29724427/acr-appropriateness-criteria-%C3%A2-colorectal-cancer-screening
#18
Courtney Moreno, David H Kim, Twyla B Bartel, Brooks D Cash, Kevin J Chang, Barry W Feig, Kathryn J Fowler, Evelyn M Garcia, Avinash R Kambadakone, Drew L Lambert, Angela D Levy, Daniele Marin, Christine M Peterson, Christopher D Scheirey, Martin P Smith, Stefanie Weinstein, Laura R Carucci
This review summarizes the relevant literature regarding colorectal screening with imaging. For individuals at average or moderate risk for colorectal cancer, CT colonography is usually appropriate for colorectal cancer screening. After positive results on a fecal occult blood test or immunohistochemical test, CT colonography is usually appropriate for colorectal cancer detection. For individuals at high risk for colorectal cancer (eg, hereditary nonpolyposis colorectal cancer, ulcerative colitis, or Crohn colitis), optical colonoscopy is preferred because of its ability to obtain biopsies to detect dysplasia...
May 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29719998/biologics-and-immunomodulators-for-treating-crohn-s-disease-developing-after-surgery-for-an-initial-diagnosis-of-ulcerative-colitis-a-review-of-current-literature
#19
Abhijeet Yadav, Joshua Foromera, Kenneth R Falchuk, Joseph D Feuerstein
Crohn's Disease (CD) or CD-like (CDL) conditions of the pouch are rare long-term inflammatory complications of patients who were initially diagnosed with ulcerative colitis (UC) who undergo total proctocolectomy with ileo-anal anastomosis (IPAA). There are no societal guidelines nor a consensus on their treatment, resulting in significant challenges for clinicians for their diagnosis and management. It is important to differentiate them from other more common pouch-related complications like pouchitis, cuffitis, irritable pouch syndrome, surgery associated stricture, and fistula...
May 2, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29705029/usefulness-of-contrast-enhanced-ultrasound-ceus-in-inflammatory-bowel-disease-ibd
#20
REVIEW
Silvia Pecere, Grainne Holleran, Maria Elena Ainora, Matteo Garcovich, Franco Scaldaferri, Antonio Gasbarrini, Maria Assunta Zocco
Intestinal ultrasonography has emerged as a cheap, non-invasive and readily accessible modality for the assessment of a number of gastroenterological diseases. Over the last decade, particularly due to the widespread use of biological agents in Inflammatory Bowel Disease (IBD), guidelines regarding management and follow-up advise more regular disease assessment and surveillance in order to guide treatment adjustments, and provide more personalised care. Given the young age of the majority of patients with IBD the availability of an alternative modality to harmful radiation or the risks of endoscopy for this indication offers an appealing advantage...
April 3, 2018: Digestive and Liver Disease
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