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ulcerative colitis guidelines

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https://www.readbyqxmd.com/read/28210080/il23r-single-nucleotide-polymorphisms-could-be-either-beneficial-or-harmful-in-ulcerative-colitis
#1
Sarah Fischer, Erzsébet Kövesdi, Lili Magyari, Veronika Csöngei, Kinga Hadzsiev, Béla Melegh, Péter Hegyi, Patrícia Sarlós
AIM: To investigate the association of seven single nucleotide polymorphisms (SNPs) of the IL23R gene with the clinical picture of ulcerative colitis (UC). METHODS: Genomic DNA samples of 131 patients (66 males, 65 females, mean age 55.4 ± 15.8 years) with Caucasian origin, diagnosed with UC were investigated. The diagnosis of UC was based on the established clinical, endoscopic, radiological, and histopathological guidelines. DNA was extracted from peripheral blood leukocytes by routine salting out method...
January 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28161290/safety-of-treatments-for-inflammatory-bowel-disease-clinical-practice-guidelines-of-the-italian-group-for-the-study-of-inflammatory-bowel-disease-ig-ibd
#2
Livia Biancone, Vito Annese, Sandro Ardizzone, Alessandro Armuzzi, Emma Calabrese, Flavio Caprioli, Fabiana Castiglione, Michele Comberlato, Mario Cottone, Silvio Danese, Marco Daperno, Renata D'Incà, Giuseppe Frieri, Walter Fries, Paolo Gionchetti, Anna Kohn, Giovanni Latella, Monica Milla, Ambrogio Orlando, Claudio Papi, Carmelina Petruzziello, Gabriele Riegler, Fernando Rizzello, Simone Saibeni, Maria Lia Scribano, Maurizio Vecchi, Piero Vernia, Gianmichele Meucci
Inflammatory bowel diseases are chronic conditions of unknown etiology, showing a growing incidence and prevalence in several countries, including Italy. Although the etiology of Crohn's disease and ulcerative colitis is unknown, due to the current knowledge regarding their pathogenesis, effective treatment strategies have been developed. Several guidelines are available regarding the efficacy and safety of available drug treatments for inflammatory bowel diseases. Nevertheless, national guidelines provide additional information adapted to local feasibility, costs and legal issues related to the use of the same drugs...
January 17, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28150131/inflammatory-bowel-disease-unclassified-in-children-diagnosis-and-pharmacological-management
#3
Giulia D'Arcangelo, Marina Aloi
Inflammatory bowel diseases are chronic disorders of the gastrointestinal tract that include Crohn's disease (CD), ulcerative colitis (UC) and inflammatory bowel disease-unclassified (IBDU). The latter defines a subgroup of patients with clinical and endoscopic evidence of chronic colitis, without specific features of either CD or UC. These patients will possibly be re-classified as having UC or CD during the follow-up, although a significant percentage of them will keep the diagnosis of IBDU. IBDU is the rarest subtype of IBD, both in children and in adults, although it is twice as common among the pediatric population, especially in the younger ages...
February 1, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28135789/-second-korean-guideline-for-the-management-of-ulcerative-colitis
#4
REVIEW
Chang Hwan Choi, Won Moon, You Sun Kim, Eun Soo Kim, Bo In Lee, Yunho Jung, Yong Sik Yoon, Heeyoung Lee, Dong Il Park, Dong Soo Han
Ulcerative colitis (UC) is a chronic inflammatory bowel disorder characterized by a relapsing and remitting course. The direct and indirect costs of the treatment of UC are high, and the quality of life of patients is reduced, especially during exacerbation of the disease. The incidence and prevalence of UC in Korea are still lower than those of Western countries, but have been rapidly increasing during the past decades. Various medical and surgical therapies, including biologics, are currently used for the management of UC...
January 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28131521/espen-guideline-clinical-nutrition-in-inflammatory-bowel-disease
#5
Alastair Forbes, Johanna Escher, Xavier Hébuterne, Stanisław Kłęk, Zeljko Krznaric, Stéphane Schneider, Raanan Shamir, Kalina Stardelova, Nicolette Wierdsma, Anthony E Wiskin, Stephan C Bischoff
INTRODUCTION: The ESPEN guideline presents a multidisciplinary focus on clinical nutrition in inflammatory bowel disease (IBD). METHODOLOGY: The guideline is based on extensive systematic review of the literature, but relies on expert opinion when objective data were lacking or inconclusive. The conclusions and 64 recommendations have been subject to full peer review and a Delphi process in which uniformly positive responses (agree or strongly agree) were required...
December 31, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28128675/clinicians-adherence-to-international-guidelines-in-the-clinical-care-of-adults-with-inflammatory-bowel-disease
#6
Belinda D Jackson, Danny Con, Danny Liew, Peter De Cruz
BACKGROUND: Although evidence-based guidelines have been developed for inflammatory bowel disease (IBD), the extent to which they are followed is unclear. The objective of this study was to review clinicians' adherence to international IBD guidelines. METHODS: Retrospective data collection of patients attending a tertiary Australian hospital IBD clinic over a 12-month period. Management practices were audited and compared to ECCO (European Crohn's and Colitis Organization) guidelines...
January 27, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28068895/can-surgery-for-inflammatory-bowel-disease-be-personalized
#7
Antonino Spinelli, Alessandra Marano, Claudio Bacchelli, Nicolò Maria Mariani, Marco Montorsi, Paulo Gustavo Kotze
In the treatment of Inflammatory Bowel Diseases (IBD) despite advances in medical therapies, surgery has maintained a leading role in the management of complications of the disease, as well as in cases of failure of medical therapy. Surgery has become more and more minimally invasive, struggling for a difficult balance between guidelines and personalized treatment tailored on the single patient's need. In the present paper, the authors discuss the possible role for a personalization in debated fields of surgical treatment of Crohn&s disease and ulcerative colitis...
January 5, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28066941/surveillance-for-dysplasia-in-patients-with-ulcerative-colitis-discrepancy-between-guidelines-and-practice
#8
Masaru Shinozaki, Kiyonori Kobayashi, Reiko Kunisaki, Tadakazu Hisamatsu, Makoto Naganuma, Kenichi Takahashi, Yasushi Iwao, Yasuo Suzuki, Mamoru Watanabe, Michio Itabashi, Akira Torii, Masakazu Takazoe, Akira Sugita
BACKGROUND AND AIM: The risk of developing colorectal cancer is higher in patients with ulcerative colitis (UC) than in the general population. Guidelines recommend surveillance colonoscopy (SCS) to reduce mortality; however, few studies have assessed physicians' adherence to guidelines. This study was aimed to clarify the current status of SCS and adherence to guidelines through the characteristics of cancer/dysplasia surveillance for UC patients in Japan. METHODS: A questionnaire was mailed to 541 physicians who attended meetings on inflammatory bowel disease...
January 9, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28009685/there-is-significant-practice-pattern-variability-in-the-management-of-the-hospitalized-ulcerative-colitis-patient-at-a-tertiary-care-and-ibd-referral-center
#9
Shailja C Shah, Steven Naymagon, Benjamin L Cohen, Bruce E Sands, Marla C Dubinsky
BACKGROUND AND GOALS: Despite published clinical guidelines, substantive data underlying the approach to the management of hospitalized ulcerative colitis (UC) patients failing outpatient therapy are lacking. Variability in practice is therefore not uncommon and may impact clinical outcomes. The degree of variability, however, is not well-studied. Our aim was to evaluate variability in management of the hospitalized UC patient to inform future efforts targeting care optimization for this high-risk population...
December 22, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27951611/clinical-implications-of-low-grade-dysplasia-found-during-inflammatory-bowel-disease-surveillance-a-retrospective-study-comparing-chromoendoscopy-and-white-light-endoscopy
#10
Joren R Ten Hove, Erik Mooiweer, Andrea E van der Meulen de Jong, Evelien Dekker, Cyriel Y Ponsioen, Peter D Siersema, Bas Oldenburg
Background and study aims Current guidelines recommend the use of pancolonic chromoendoscopy for surveillance of patients with inflammatory bowel disease (IBD). It is currently unknown whether low grade dysplasia (LGD) found using chromoendoscopy carries a similar risk of high grade dysplasia (HGD) or colorectal cancer (CRC) compared with LGD detected using white-light endoscopy (WLE). The aim of this study was to compare the risk of advanced neoplasia, a combined endpoint of HGD and CRC, during follow-up after detection of lesions containing LGD identified with either chromoendoscopy or WLE...
February 2017: Endoscopy
https://www.readbyqxmd.com/read/27927666/epigenetic-biomarkers-in-progression-from-non-dysplastic-barrett-s-oesophagus-to-oesophageal-adenocarcinoma-a-systematic-review-protocol
#11
T Nieto, C L Tomlinson, J Dretzke, S Bayliss, M Dilworth, A D Beggs, O Tucker
INTRODUCTION: Barrett's oesophagus (BO), a metaplastic condition affecting the lower oesophagus due to long-standing gastro-oesophageal reflux and chronic inflammation, is a precursor lesion for oesophageal adenocarcinoma (OADC). There is no clinical test to predict which patients with BO will progress to OADC. The British Society of Gastroenterology recommends endoscopic surveillance of patients with BO. Epigenetic changes have been well characterised in the neoplastic progression of ulcerative colitis to colonic carcinoma, another gastrointestinal cancer associated with chronic inflammation...
December 7, 2016: BMJ Open
https://www.readbyqxmd.com/read/27926558/postoperative-venous-thromboembolism-in-patients-undergoing-abdominal-surgery-for-ibd-a-common-but-rarely-addressed-problem
#12
Matthew T Brady, Gregory J Patts, Amy Rosen, George Kasotakis, Jeffrey J Siracuse, Teviah Sachs, Angela Kuhnen, Hiroko Kunitake
BACKGROUND: Venous thromboembolism after abdominal surgery occurs in 2% to 3% of patients with Crohn's disease and ulcerative colitis. However, no evidence-based guidelines currently exist to guide postdischarge prophylactic anticoagulation. OBJECTIVE: We sought to determine the use of postoperative postdischarge venous thromboembolism chemical prophylaxis, 90-day venous thromboembolism rates, and factors associated with 90-day thromboembolic events in IBD patients following abdominal surgery...
January 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27890853/chromoendoscopy-for-surveillance-in-ulcerative-colitis-and-crohn-s-disease-a-systematic-review-of-randomized-trials
#13
REVIEW
Andrea Iannone, Marinella Ruospo, Germaine Wong, Mariabeatrice Principi, Michele Barone, Giovanni Fm Strippoli, Alfredo Di Leo
BACKGROUND & AIMS: Key international guideline agencies recommend dysplasia surveillance in inflammatory bowel diseases with chromoendoscopy. We performed a systematic review of randomized trials comparing chromoendoscopy versus other endoscopic techniques for dysplasia surveillance in inflammatory bowel diseases. METHODS: We searched MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials for relevant studies published through September 2016. We estimated risk ratios (RR) for dichotomous outcomes (all-cause/colorectal cancer-related mortality, time to interval cancer, patients with dysplasia, total/subtypes of dysplastic lesions, dysplasia detected by targeted biopsies, adverse events), mean differences (MD) for continuous outcomes (procedural time, costs, total/targeted biopsies) and their 95% confidence intervals (CI) using a random-effects model...
November 24, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27889728/pediatric-inflammatory-bowel-disease
#14
Akshay Kapoor, Vidyut Bhatia, Anupam Sibal
Background: The incidence of inflammatory bowel disease is increasing in the pediatric population worldwide. NEED AND PURPOSE OF REVIEW: There is paucity of high quality scientific data regarding pediatric inflammatory bowel disease. Most of the guidelines are offshoots of work done in adults, which have been adapted over time to diagnose and treat pediatric patients. This is in part related to the small numbers in pediatric inflammatory bowel disease and less extensive collaboration for multicentric trials both nationally and internationally...
November 15, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27884517/endoscopic-morphologic-features-of-ulcerative-colitis-associated-dysplasia-classified-according-to%C3%A2-the%C3%A2-scenic%C3%A2-consensus-statement
#15
Shinya Sugimoto, Makoto Naganuma, Yasushi Iwao, Katsuyoshi Matsuoka, Masayuki Shimoda, Shuji Mikami, Shinta Mizuno, Yoshihiro Nakazato, Kosaku Nanki, Nagamu Inoue, Haruhiko Ogata, Takanori Kanai
BACKGROUND AND AIMS: Recent advances in endoscopic equipment and diagnostic techniques have made possible the detection of early dysplasia in the inflamed mucosa of ulcerative colitis (UC). The SCENIC consensus statement recommends the use of unified terminology for the morphology of dysplasia. In this study, we investigated the endoscopic features of high-grade dysplasia (HGD) in a clinical setting. METHODS: We retrospectively identified 62 patients with UC who were diagnosed with colitis-associated cancer or HGD between 1997 and 2015...
November 21, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27878770/a-low-cost-method-for-chromoendoscopy-for-surveillance-in-ulcerative-colitis
#16
Sawan Bopanna, Saurabh Kedia, Vineet Ahuja
The risk of colorectal cancer in Indian patients with long-standing ulcerative colitis is high and similar to that in the West. Surveillance for dysplasia in these patients is therefore important. Recent studies and guidelines suggest an increasing role for chromoendoscopy-guided biopsy in surveillance for dysplasia. We report our experience with the technique of chromoendoscopy and an economical method of performing it. Reconstituting indigo carmine from a powder form rather than the dyes available commercially is a better economical alternative and should help make chromoendoscopy the standard of care for dysplasia surveillance across the country...
November 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/27822107/the-danish-national-registry-for-biological-therapy-in-inflammatory-bowel-disease
#17
REVIEW
Lone Larsen, Michael Dam Jensen, Michael Due Larsen, Rasmus Gaardskær Nielsen, Niels Thorsgaard, Ida Vind, Signe Wildt, Jens Kjeldsen
AIM: The aims of The Danish National Registry for Biological Therapy in Inflammatory Bowel Disease are to ensure that biological therapy and the clinical management of patients with inflammatory bowel disease (IBD) receiving biological treatment are in accordance with the national clinical guidelines and, second, the database allows register-based clinical epidemiological research. STUDY POPULATION: The study population comprises all Danish patients with IBD (both children and adults) with ulcerative colitis, Crohn's disease, and IBD unclassified who receive biological therapy...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27759417/oral-manifestations-of-gastrointestinal-diseases-in-children-part-3-ulcerative-colitis-and-gastro-oesophageal-reflux-disease
#18
C Mantegazza, F Angiero, G V Zuccotti
Alterations of the oral cavity are common in children: 22% of children aged less than 4 years and 44% of those aged more than 12 develop dental erosion, 9-95% of children in Europe and in North America develop gingivitis, with adolescents showing a prevalence of more than 60% [Italian Ministry of Health, Guidelines 2013]. Alterations within the oral cavity can be the first sign of systemic diseases and may thus allow for an early diagnosis and treatment. In particular, being the oral cavity a part of the gastrointestinal system, oral alterations can be an expression of a gastrointestinal disease...
September 2016: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/27695502/an-indirect-comparison-of-infliximab-versus-adalimumab-or-golimumab-for-active-ulcerative-colitis
#19
REVIEW
Paweł Kawalec, Andrzej Pilc
INTRODUCTION: The aim of the study was to compare adalimumab or golimumab with infliximab in patients with moderately-to-severely active ulcerative colitis (UC). MATERIAL AND METHODS: This paper was prepared according to the PRISMA guidelines. The systematic literature search was performed in PubMed, Embase, and Cochrane Library. No direct head-to-head comparisons for infliximab vs. adalimumab or golimumab were available so an indirect comparison according to the Bucher method was performed after a homogeneity evaluation of the included studies...
October 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27613257/low-rate-of-dysplasia-detection-in-mucosa-surrounding-dysplastic-lesions-in-patients-undergoing-surveillance-for-inflammatory-bowel-diseases
#20
Joren R Ten Hove, Erik Mooiweer, Evelien Dekker, Andrea E van der Meulen-de Jong, G Johan A Offerhaus, Cyriel Y Ponsioen, Peter D Siersema, Bas Oldenburg
BACKGROUND & AIMS: When dysplastic lesions are encountered during surveillance colonoscopy of patients with inflammatory bowel disease (IBD), guidelines recommend collection of additional biopsies from the surrounding mucosa to ensure the lesion has been adequately circumscribed. We aimed to determine the rate of dysplasia in mucosa biopsies collected from tissues surrounding dysplastic lesions during IBD surveillance. METHODS: In a retrospective study, we collected endoscopy and pathology reports from 1065 patients undergoing colonoscopic surveillance for IBD from 2000 through 2015 at 3 centers in the Netherlands...
September 6, 2016: Clinical Gastroenterology and Hepatology
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