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poly-unsaturated fatty acids

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https://www.readbyqxmd.com/read/28608804/phytosterols-and-omega-3-supplementation-exert-novel-regulatory-effects-on-metabolic-and-inflammatory-pathways-a-proteomic-study
#1
Carmen Lambert Judit Cubedo, Teresa Padró, Joan Sánchez-Hernández, Rosa M Antonijoan, Antonio Perez, Lina Badimon
Cardiovascular disease (CVD) remains one of the major causes of death and disability worldwide. In addition to drug treatment, nutritional interventions or supplementations are becoming a health strategy for CVD prevention. Phytosterols (PhyS) are natural components that have been shown to reduce cholesterol levels; while poly-unsaturated fatty acids (PUFA), mainly omega-3 (ω3) fatty acids, have shown to reduce triglyceride levels. Here we aimed to investigate whether the proteins in the main lipoproteins (low density lipoproteins (LDL) and high density lipoproteins (HDL)) as well as proteins in the lipid free plasma fraction (LPDP) were regulated by the intake of PhyS-milk or ω3-milk, in overweight healthy volunteers by a proteomic based systems biology approach...
June 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28595582/enhancing-the-quality-and-lipid-stability-of-chicken-nuggets-using-natural-antioxidants
#2
Muhammad Sajid Arshad, Ali Imran, Muhammad Tahir Nadeem, Muhammad Sohaib, Farhan Saeed, Faqir Muhammad Anjum, Joong-Ho Kwon, Shahzad Hussain
BACKGROUND: Current day consumers prefer natural antioxidants to synthetic antioxidants because they are more active. However, the activity generally depends on the specific condition and composition of food. The aim of this study was to investigate the effect of wheat germ oil and α-lipoic acid on the quality characteristics, antioxidant status, fatty acid profile, and sensory attributes of chicken nuggets. METHODS: Six types of diets were prepared for feeding the chickens to evaluate the quality of nuggets made from the leg meat of these experimental animals...
June 8, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28593722/macronutrient-intake-associated-with-weight-gain-in-adolescent-girls-with-anorexia-nervosa
#3
Charumathi Baskaran, Traci L Carson, Karen J Campoverde Reyes, Kendra R Becker, Meghan J Slattery, Shreya Tulsiani, Kamryn T Eddy, Ellen J Anderson, Jane L Hubbard, Madhusmita Misra, Anne Klibanski
OBJECTIVE: Adolescents and women with anorexia nervosa (AN) are known to severely restrict total calorie and fat intake. However, data are limited regarding specific macronutrient intake associated with weight gain in AN. OBJECTIVE: To prospectively investigate dietary macronutrient composition associated with weight gain in adolescent girls with AN. METHOD: A prospective naturalistic study of 90 girls 12-18 years old; 45 with AN and 45 healthy normal-weight-controls over a 6-12-month period...
June 7, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28579398/evaluation-of-the-expression-level-of-12-15-lipoxygenase-and-the-related-inflammatory-factors-ccl5-ccl3-in-respiratory-syncytial-virus-infection-in-mice-model
#4
Vahid Salimi, Ali Ramezani, Habibollah Mirzaei, Alireza Tahamtan, Ebrahim Faghihloo, Farhad Rezaei, Maryam Naseri, Louis Bont, Talat Mokhtari-Azad, Masoumeh Tavakoli-Yaraki
Human respiratory syncytial virus (RSV) is a leading cause of acute respiratory infection during early childhood and imposes a great burden on patients, parents, and society. Disease is thought to be caused, at least partially, by an excessive immune response. Pulmonary leukocyte infiltration is the result of a coordinated expression of diverse chemokines with distinct cellular specificities. Lipoxygenases (LOXs), as a key enzyme catalyzing deoxygenation of poly unsaturated fatty acids, regulate inflammation and have been suggested to play an important role in the immune response in viral infection...
June 1, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28570057/differences-in-the-oxylipid-profiles-of-bovine-milk-and-plasma-at-different-stages-of-lactation
#5
Matthew J Kuhn, Vengai Mavangira, Jeffery C Gandy, Chen Zhang, A Daniel Jones, Lorraine M Sordillo
Mastitis is caused by a bacterial infection of the mammary gland, which reduces both milk quality and quantity produced for human consumption. The incidence and severity of bovine mastitis are greatest during the periparturient period that results from dysfunctional inflammatory responses and causes damage to milk synthesizing tissues. Oxylipids are potent fatty acid-derived mediators that control the onset and resolution of the inflammatory response. The purpose of this study was to investigate how oxylipid profiles change in bovine milk at different stages of the lactation cycle...
June 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28557532/an-experimental-model-to-study-the-impact-of-lipid-oxidation-on-contact-lens-deposition-in-vitro
#6
Burkhardt S Schuett, Thomas J Millar
PURPOSE: This study was to establish a controlled in vitro test system to study the effect of lipid oxidation on lipid deposition on contact lenses. METHODS: Fatty acids with varying degree of unsaturation were oxidized using the Fenton reaction. The degree of lipid oxidation and the lipid moieties formed during the oxidation were identified and estimated by various lipid staining techniques following separation with thin-layer chromatography, and by measuring thiobarbituric acid reactive substances or peroxides in solution...
May 30, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28548491/deposition-of-a-sorbent-into-a-recession-on-a-solid-support-provides-a-new-mechanically-robust-solid-phase-micro-extraction-device
#7
Justen J Poole, Jonathan J Grandy, Miao Yu, Ezel Boyaci, German A Gomez Rios, Nathaly Reyes-Garcés, Barbara Bojko, Harmen Vander Heide, Janusz Pawliszyn
To date, solid-phase microextraction (SPME) fibers used for in-vivo bio-analysis can be too fragile and flexible, which limits suitability for direct tissue sampling. As a result, these devices often require a sheathing needle to pre-puncture robust sample matrices and protect the extraction phase from mechanical damage. To address this limitation, a new SPME device is herein presented which incorporates an extraction phase recessed into the body of a solid needle. This device requires no additional support or shielding during puncture events through protective tissue...
May 26, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28442322/in-vitro-and-in-vivo-antitumor-activities-of-t-3764518-a-novel-and-orally-available-small-molecule-stearoyl-coa-desaturase-1-inhibitor
#8
Satoru Nishizawa, Hiroyuki Sumi, Yoshihiko Satoh, Yukiko Yamamoto, Satoshi Kitazawa, Kohei Honda, Hideo Araki, Kazuyo Kakoi, Keisuke Imamura, Masako Sasaki, Ikuo Miyahisa, Yoshinori Satomi, Ryuuichi Nishigaki, Megumi Hirayama, Kazunobu Aoyama, Hironobu Maezaki, Takahito Hara
Most cancer cells are characterized by elevated lipid biosynthesis. The rapid proliferation of cancer cells requires de novo synthesis of fatty acids. Stearoyl-CoA desaturase-1 (SCD1), a key enzyme for lipogenesis, is overexpressed in various types of cancer and plays an important role in cancer cell proliferation. Therefore, it has been studied as a candidate target for cancer therapy. In this study, we demonstrate the pharmacological properties of T-3764518, a novel and orally available small molecule inhibitor of SCD1...
July 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28390301/mercury-exposure-serum-antinuclear-antibodies-and-serum-cytokine-levels-in-the-long-island-study-of-seafood-consumption-a-cross-sectional-study-in-ny-usa
#9
Rebecca N Monastero, Roxanne Karimi, Jennifer F Nyland, James Harrington, Keith Levine, Jaymie R Meliker
Mercury (Hg) is a well-known neurotoxin, and has been more recently studied specifically as an immunotoxin. In experimental and a few epidemiologic studies, Hg has been associated with distinct cytokine profiles and antinuclear antibody (ANA) positivity, though patterns at lower levels of exposure, typical of seafood consumers with a western diet, are not well characterized. Seafood consumers (n=287) recruited on Long Island, NY completed food frequency and health questionnaires and provided blood for analysis of Hg, poly-unsaturated fatty acids (omega-3 and omega-6 fatty acids), selenium (Se), ANA, and several cytokines (IL-1β, IL-4, IL-10, TNF-α, IL-17, IFN-γ, and IL-1ra)...
July 2017: Environmental Research
https://www.readbyqxmd.com/read/28388313/arachidonic-acid-and-docosahexanoic-acid-enhance-platelet-formation-from-human-apheresis-derived-cd34-cells
#10
Ankita Dhenge, Kedar Limbkar, Sameer Melinkeri, Vaijayanti Prakash Kale, Lalita Limaye
An Aberration in megakaryopoiesis and thrombopoiesis, 2 important processes that maintain hemostasis, leads to thrombocytopenia. Though platelet transfusions are used to treat this condition, blood banks frequently face a shortage of platelets. Therefore, methods to generate platelets on a large scale are strongly desirable. However, to generate megakaryocytes (MKs) and platelets (PLTs) in numbers sufficient for clinical application, it is essential to understand the mechanism of platelet production and explore efficient strategies accordingly...
May 19, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28351404/longitudinal-10-year-changes-in-dietary-intake-and-associations-with-cardio-metabolic-risk-factors-in-the-northern-sweden-health-and-disease-study
#11
Anna Winkvist, Sofia Klingberg, Lena Maria Nilsson, Maria Wennberg, Frida Renström, Göran Hallmans, Kurt Boman, Ingegerd Johansson
BACKGROUND: Dietary risks today constitute the largest proportion of disability-adjusted life years (DALYs) globally and in Sweden. An increasing number of people today consume highly processed foods high in saturated fat, refined sugar and salt and low in dietary fiber, vitamins and minerals. It is important that dietary trends over time are monitored to predict changes in disease risk. METHODS: In total, 15,995 individuals with two visits 10 (±1) years apart in the population-based Västerbotten Intervention Programme 1996-2014 were included...
March 28, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28265702/from-current-algae-products-to-future-biorefinery-practices-a-review
#12
Michel H M Eppink, Giuseppe Olivieri, Hans Reith, Corjan van den Berg, Maria J Barbosa, Rene H Wijffels
Microalgae are considered to be one of the most promising next generation bio-based/food feedstocks with a unique lipid composition, high protein content, and an almost unlimited amount of other bio-active molecules. High-value components such as the soluble proteins, (poly) unsaturated fatty acids, pigments, and carbohydrates can be used as an important ingredient for several markets, such as the food/feed/chemical/cosmetics and health industries. Although cultivation costs have decreased significantly in the last few decades, large microalgae production processes become economically viable if all complex compounds are optimally valorized in their functional state...
March 7, 2017: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/28254293/high-fluorescence-emission-silver-nano-particles-coated-with-poly-styrene-g-soybean-oil-graft-copolymers-antibacterial-activity-and-polymerization-kinetics
#13
Baki Hazer, Özlem A Kalaycı
Autoxidation of poly unsaturated fatty acids makes negative effect on foods. In this work, this negative effect was turned to a great advantage using autoxidized soybean oil as a macroperoxide nanocomposite initiator containing silver nano particles in free radical polymerization of vinyl monomers. The synthesis of soybean oil macro peroxide was carried out by exposing soybean oil to air oxygen with the presence of silver nanoparticles (Ag NPs) at room temperature. Autoxidized soybean oil macroperoxide containing silver nanoparticles (Agsbox) successfully initiated the free radical polymerization of styrene in order to obtain Polystyrene (PS)-g-soybean oil graft copolymer containing Ag NPs...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28242935/trans-himalayan-rhodiola-imbricata-edgew-root-a-novel-source-of-dietary-amino-acids-fatty-acids-and-minerals
#14
Amol B Tayade, Priyanka Dhar, Jatinder Kumar, Manu Sharma, Om P Chaurasia, Ravi B Srivastava
Roots of Rhodiola imbricata Edgew from Indian trans-Himalayan cold desert known for their nutritional and medicinal attributes were evaluated for the dietary amino acids, fatty acids and mineral composition. Nine essential and twelve non-essential amino acids were quantified. The contents ranged between 91.33 and 1640.67 µg/g. Histidine (1434.33 µg/g), lysine (1329.33 µg/g) and threonine (1015.67 μg/g) were dominant essential amino acids, while glycine (1640.67 µg/g), proline (1263.67 µg/g), alanine (1142...
February 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28237087/e-configuration-structures-of-epa-and-dha-derived-from-euphausia-superba-and-their-significant-inhibitive-effects-on-growth-of-human-cancer-cell-lines-in-vitro
#15
Weilong Zheng, Xudong Wang, Wenjing Cao, Bowen Yang, Ying Mu, Yuesheng Dong, Zhilong Xiu
Many bioactive components such as poly-unsaturated fatty acids (e.g. EPA and DHA), phospholipids and astaxanthin are known in Antarctic krill (Euphausia superba) oil. The krill DHA and EPA are generally considered to be similar to natural ones. However, two chemical compounds which were separated from Antarctic krill oil and identified as EPA and DHA by HRESIMS and NMR acted much more effective inhibitive activities on growth of several cell lines (U937, K562, SMMC-7721, PC-3, MDA-MB-231, HL60 and MCF-7) than those from sturgeon liver and commercial fish oil...
February 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28216958/-1-h-nmr-based-serum-metabolomics-reveals-erythromycin-induced-liver-toxicity-in-albino-wistar-rats
#16
Atul Rawat, Durgesh Dubey, Anupam Guleria, Umesh Kumar, Amit K Keshari, Swati Chaturvedi, Anand Prakash, Sudipta Saha, Dinesh Kumar
INTRODUCTION: Erythromycin (ERY) is known to induce hepatic toxicity which mimics other liver diseases. Thus, ERY is often used to produce experimental models of drug-induced liver-toxicity. The serum metabolic profiles can be used to evaluate the liver-toxicity and to further improve the understanding of underlying mechanism. OBJECTIVE: To establish the serum metabolic patterns of Erythromycin induced hepatotoxicity in albino wistar rats using (1)H NMR based serum metabolomics...
October 2016: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28215784/comparison-of-derivatization-ionization-techniques-for-liquid-chromatography-tandem-mass-spectrometry-analysis-of-oxylipins
#17
Sven W Meckelmann, Stefan Hellhake, Maryvonne Steuck, Michael Krohn, Nils Helge Schebb
The performance of two derivatization and ionization techniques for the quantitative reversed phase liquid chromatography (LC)- mass spectrometry (MS) analysis of hydroxy fatty acids (OH-PUFA) in plasma was evaluated: One used AMPP (N-(4-aminomethylphenyl)pyridinium chloride) leading to a positive charged amid-derivate which can be detected by electrospray ionization (ESI)-MS. Second yielded penta fluorobenzyl bromide (PFB) ester derivates allowing detection in electron capture atmospheric pressure chemical ionization (ecAPCI)-MS...
May 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28187761/erratum-to-maternal-intake-of-seafood-and-supplementary-long-chain-n-3-poly-unsaturated-fatty-acids-and-preterm-delivery
#18
Anne Lise Brantsæter, Linda Englund-Ögge, Margareta Haugen, Bryndis Eva Birgisdottir, Helle Katrine Knutsen, Verena Sengpiel, Ronny Myhre, Jan Alexander, Roy M Nilsen, Bo Jacobsson, Helle Margrete Meltzer
No abstract text is available yet for this article.
February 10, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28121994/diet-and-adhd-reviewing-the-evidence-a-systematic-review-of-meta-analyses-of-double-blind-placebo-controlled-trials-evaluating-the-efficacy-of-diet-interventions-on-the-behavior-of-children-with-adhd
#19
Lidy M Pelsser, Klaas Frankena, Jan Toorman, Rob Rodrigues Pereira
INTRODUCTION: Attention-deficit/hyperactivity disorder (ADHD) is a debilitating mental health problem hampering the child's development. The underlying causes include both genetic and environmental factors and may differ between individuals. The efficacy of diet treatments in ADHD was recently evaluated in three reviews, reporting divergent and confusing conclusions based on heterogeneous studies and subjects. To address this inconsistency we conducted a systematic review of meta-analyses of double-blind placebo-controlled trials evaluating the effect of diet interventions (elimination and supplementation) on ADHD...
2017: PloS One
https://www.readbyqxmd.com/read/28115966/the-effect-of-walnut-oil-consumption-on-blood-sugar-in-patients-with-diabetes-mellitus-type-2
#20
Mohammadjavad Zibaeenezhad, Kamran Aghasadeghi, Hossein Hakimi, Hassan Yarmohammadi, Farzad Nikaein
BACKGROUND: Prevalence of diabetes mellitus type 2 (DM) is increasing globally. Considering the potential role of poly-unsaturated fatty acids in prevention of DM type 2 and lipid profiles improvement, some studies have been carried out on walnut. However, there are no studies on control of blood sugar in DM type 2 patients using walnut. OBJECTIVES: The current study aimed to evaluate the effect of walnut oil on blood sugar in DM type 2 patients. METHODS: This randomized control clinical trial was performed on 100 patients with DM type 2...
July 2016: International Journal of Endocrinology and Metabolism
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