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https://www.readbyqxmd.com/read/29156720/novel-strategies-of-raman-imaging-for-brain-tumor-research
#1
Imiela Anna, Polis Bartosz, Polis Lech, Abramczyk Halina
Raman diagnostics and imaging have been shown to be an effective tool for the analysis and discrimination of human brain tumors from normal structures. Raman spectroscopic methods have potential to be applied in clinical practice as they allow for identification of tumor margins during surgery. In this study, we investigate medulloblastoma (grade IV WHO) (n= 5), low-grade astrocytoma (grades I-II WHO) (n =4), ependymoma (n=3) and metastatic brain tumors (n= 1) and the tissue from the negative margins used as normal controls...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156677/overcoming-resistance-to-single-agent-therapy-for-oncogenic-braf-gene-fusions-via-combinatorial-targeting-of-mapk-and-pi3k-mtor-signaling-pathways
#2
Payal Jain, Amanda Silva, Harry J Han, Shih-Shan Lang, Yuankun Zhu, Katie Boucher, Tiffany E Smith, Aesha Vakil, Patrick Diviney, Namrata Choudhari, Pichai Raman, Christine M Busch, Tim Delaney, Xiaodong Yang, Aleksandra K Olow, Sabine Mueller, Daphne Haas-Kogan, Elizabeth Fox, Phillip B Storm, Adam C Resnick, Angela J Waanders
Pediatric low-grade gliomas (PLGGs) are frequently associated with activating BRAF gene fusions, such as KIAA1549-BRAF, that aberrantly drive the mitogen activated protein kinase (MAPK) pathway. Although RAF inhibitors (RAFi) have been proven effective in BRAF-V600E mutant tumors, we have previously shown how the KIAA1549-BRAF fusion can be paradoxically activated by RAFi. While newer classes of RAFi, such as PLX8394, have now been shown to inhibit MAPK activation by KIAA1549-BRAF, we sought to identify alternative MAPK pathway targeting strategies using clinically relevant MEK inhibitors (MEKi), along with potential escape mechanisms of acquired resistance to single-agent MAPK pathway therapies...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156600/fabrication-of-semiconductor-zno-nanostructures-for-versatile-sers-application
#3
REVIEW
Lili Yang, Yong Yang, Yunfeng Ma, Shuai Li, Yuquan Wei, Zhengren Huang, Nguyen Viet Long
Since the initial discovery of surface-enhanced Raman scattering (SERS) in the 1970s, it has exhibited a huge potential application in many fields due to its outstanding advantages. Since the ultra-sensitive noble metallic nanostructures have increasingly exposed themselves as having some problems during application, semiconductors have been gradually exploited as one of the critical SERS substrate materials due to their distinctive advantages when compared with noble metals. ZnO is one of the most representative metallic oxide semiconductors with an abundant reserve, various and cost-effective fabrication techniques, as well as special physical and chemical properties...
November 19, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29156315/genus-and-species-level-identification-of-dermatophyte-fungi-by-surface-enhanced-raman-spectroscopy
#4
Evelin Witkowska, Tomasz Jagielski, Agnieszka Kamińska
This paper demonstrates that surface-enhanced Raman spectroscopy (SERS) coupled with principal component analysis (PCA) can serve as a fast and reliable technique for detection and identification of dermatophyte fungi at both genus and species level. Dermatophyte infections are the most common mycotic diseases worldwide, affecting a quarter of the human population. Currently, there is no optimal method for detection and identification of fungal diseases, as each has certain limitations. Here, for the first time, we have achieved with a high accuracy, differentiation of dermatophytes representing three major genera, i...
November 3, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29156157/continuous-gradient-temperature-raman-spectroscopy-from-100-to-40%C3%A2-c-yields-new-molecular-models-of-arachidonic-acid-and-2-arachidonoyl-1-stearoyl-sn-glycero-3-phosphocholine
#5
C Leigh Broadhurst, Walter F Schmidt, Julie K Nguyen, Jianwei Qin, Kuanglin Chao, Moon S Kim
Despite its biochemical importance, a complete Raman analysis of arachidonic acid (AA, 20:4n-6) has never been reported. Gradient temperature Raman spectroscopy (GTRS) applies the temperature gradients utilized in differential scanning calorimetry (DSC) to Raman spectroscopy, providing a straightforward technique to identify molecular rearrangements that occur near and at phase transitions. Herein we utilize the GTRS technique for AA and 1-18:0, 2-20:4n-6 phosphatidyl choline (AAPC) from cryogenic to mammalian body temperatures...
December 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29156139/thermo-sensitive-phase-separation-behavior-of-poly-benzyl-methacrylate-solvate-ionic-liquid-solutions
#6
Yumi Kobayashi, Yuzo Kitazawa, Kei Hashimoto, Takeshi Ueki, Hisashi Kokubo, Masayoshi Watanabe
We report a lower critical solution temperature (LCST) behavior of binary systems consisting of poly(benzyl methacrylate) (PBnMA) and solvate ionic liquids (SILs): equimolar mixtures of triglyme (G3) or tetraglyme (G4) and lithium bis(trifluoromethanesulfonyl)amide (Li[TFSA]). We evaluated the critical temperatures (Tcs) using transmittance measurements. The stability of the glyme-Li+ complex ([Li(G3 or G4)]+) in the presence of PBnMA was confirmed using Raman spectroscopy, pulsed-field gradient spin-echo NMR (PGSE-NMR), and thermogravimetric analysis to demonstrate that the complex was not disrupted...
November 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29154675/express-preprocessing-tools-applied-to-improve-the-assessment-of-aldrin-effects-on-prostate-cancer-cells-using-raman-spectroscopy
#7
Victor Olmos, Carmen Bedia, Romà Tauler, Anna De Juan
No abstract text is available yet for this article.
January 1, 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/29154143/investigation-of-various-factors-influencing-raman-spectra-interpretation-with-the-use-of-likelihood-ratio-approach
#8
Aleksandra Michalska, Agnieszka Martyna, Grzegorz Zadora
The main aim of this study was to verify whether selected analytical parameters may affect solving the comparison problem of Raman spectra with the use of the likelihood ratio (LR) approach. Firstly the LR methodologies developed for Raman spectra of blue automotive paints obtained with the use of 785nm laser source (results published by the authors previously) were implemented for good quality spectra recorded for these paints with the use of 514.5nm laser source. For LR models construction two types of variables were used i...
November 3, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29153956/effect-of-laser-activated-bleaching-on-the-chemical-stability-and-morphology-of-intracoronal-dentin
#9
Fabiane Carneiro Lopes, Renato Roperto, Anna Akkus, Ozan Akkus, Regina Guenka Palma-Dibb, Manoel Damião de Sousa-Neto
OBJECTIVES: To evaluate the effect of the bleaching with 35% hydrogen peroxide either activated or not by a 970nm diode laser on the chemical stability and dentin surface morphology of intracoronary dentin. METHODS: Twenty-seven slabs of intracoronary dentin specimens (3×3mm) were distributed into three groups (n=9), according to surface treatment: HP - 35% hydrogen peroxide (1×4'), DL - 970nm diode laser (1×30"/0,8W/10Hz), HP+DL - 35% HP activated with 970nm diode laser (1×30"/0,8W/10Hz leaving the gel in contact to the surface for 4' after activation)...
November 13, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29153746/degree-of-conversion-of-resin-cement-with-varying-methacrylate-compositions-used-to-cement-fiber-dowels-a-raman-spectroscopy-study
#10
Abdulelah M BinMahfooz, Osama A Qutub, Thamer Y Marghalani, Mohammed F Ayad, Abdulhamaid A Maghrabi
STATEMENT OF PROBLEM: Studies on the degree of conversion of dental cement in relation to the number of methacrylate components are lacking. PURPOSE: The purpose of this in vitro study was to evaluate the degree of conversion of single- and multicomponent methacrylate-containing dental cements around opaque and translucent fiber dowels at varying depths. MATERIAL AND METHODS: Teeth were prepared for standard endodontic therapy, and a dowel space was created...
November 15, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/29153717/biomass-derived-porous-carbon-modified-glass-fiber-separator-as-polysulfide-reservoir-for-li-s-batteries
#11
Ramakrishnan Kalai Selvan, Pei Zhu, Chaoi Yan, Jiadeng Zhu, Mahmut Dirican, A Shanmugavani, Yun Sung Lee, Xiangwu Zhang
Biomass-derived porous carbon has been considered as a promising sulfur host material for lithium-sulfur batteries because of its high conductive nature and large porosity. The present study explored biomass-derived porous carbon as polysulfide reservoir to modify the surface of glass fiber (GF) separator. Two different carbons were prepared from Oak Tree fruit shells by carbonization with and without KOH activation. The KOH activated porous carbon (AC) provides a much higher surface area (796 m(2) g(-1)) than pyrolized carbon (PC) (334 m(2) g(-1))...
November 7, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29153714/polyphosphonate-ligands-from-synthesis-to-design-of-hybrid-pegylated-nanoparticles-toward-phototherapy-studies
#12
Maelle Monteil, Hanane Moustaoui, Gennaro Picardi, Fatima Aouidat, Nadia Djaker, Marc Lamy de La Chapelle, Marc Lecouvey, Jolanda Spadavecchia
The use of phosphonate ligands to modify the nanoparticle (NPs) surface has attracted a strong interest in the last years for the design of highly functional hybrid materials. Here, we applied a methodology to synthesize bisphosphonates having functionalized PEG side chains with a specific length in order to design a novel class of hybrid nanomaterials composed by tetraphosphonate-complex-gold COOH-terminated PEG-coated NPs (Bis-PO-PEG-AuNPs). The synthetic approach consist in three steps: (1) Complexation between new phosphonate ligands (Bis PO) and tetrachloroauric acid (HAuCl4) to form gold clusters; (2) adsorption of COOH-terminated PEG molecules (PEG) onto Bis PO-Au complex; (3) reduction of metal ions in that vicinity, growth of gold particles and colloidal stabilization...
November 2, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29153084/combined-differential-scanning-calorimetry-raman-and-brillouin-spectroscopies-a-multiscale-approach-for-materials-investigation
#13
A Veber, M R Cicconi, H Reinfelder, D de Ligny
A new experimental setup combining DSC, Raman and Brillouin spectroscopies was developed. In order to estimate its accuracy and stability a study of silicon and the alpha-beta quartz phase transition were performed. The data obtained demonstrated good agreement with previous studies using these three different techniques. For quartz, the temperature behavior of its 147 cm(-1) Raman mode was studied in detail. Using a two-phonon coupling treatment of the Raman band, we show for the first time that its behavior can be well described by Landau theory of first-order phase transitions...
January 15, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29151920/viscoelasticity-of-amyloid-plaques-in-transgenic-mouse-brain-studied-by-brillouin-microspectroscopy-and-correlative-raman-analysis
#14
Sara Mattana, Silvia Caponi, Francesco Tamagnini, Daniele Fioretto, Francesca Palombo
Amyloidopathy is one of the most prominent hallmarks of Alzheimer's disease (AD), the leading cause of dementia worldwide, and is characterized by the accumulation of amyloid plaques in the brain parenchyma. The plaques consist of abnormal deposits mainly composed of an aggregation-prone protein fragment, β-amyloid 1-40/1-42, into the extracellular matrix. Brillouin microspectroscopy is an all-optical contactless technique that is based on the interaction between visible light and longitudinal acoustic waves or phonons, giving access to the viscoelasticity of a sample on a subcellular scale...
November 2017: Journal of Innovative Optical Health Sciences
https://www.readbyqxmd.com/read/29150729/effect-of-microemulsion-structure-on-fluorescence-and-nonlinear-optical-properties-of-rhodamine-6g
#15
M Pourtabrizi, N Shahtahmassebi, A Kompany, S Sharifi
This study is conducted to investigate the effect of nano-droplets concentration and size on linear and nonlinear optical properties of Rhodamine 6G by UV-Vis, spectrofluorometer and Z-Scan techniques. Nano-droplets were prepared by mixture of AOT, n-Decane and Water at three different water to surfactant molar ratios (W = 3, 6.7 and 40) and two dye to water mass ratios (R). At high enough dye concentration, the fluorescence intensity and its red shift depend on the concentration of dye in water nano-droplets (R)...
November 18, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/29150516/drna-seq-implicates-sulfide-as-master-regulator-of-s-0-metabolism-in-chlorobaculum-tepidum-and-other-green-sulfur-bacteria
#16
Jacob M Hilzinger, Vidhyavathi Raman, Kevin E Shuman, Brian J Eddie, Thomas E Hanson
The green sulfur bacteria (Chlorobiaceae) are anaerobes that use electrons from reduced sulfur compounds (sulfide, S(0), and thiosulfate) as electron donors for photoautotrophic growth. Chlorobaculum tepidum, the model system for the Chlorobiaceae, both produces and consumes extracellular S(0) globules depending on the availability of sulfide in the environment. These physiological changes imply significant changes in gene regulation, which has been observed when sulfide is added to Cba. tepidum growing on thiosulfate...
November 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29150282/artesunate-quercetin-luteolin-dual-drug-nanofacilitated-synergistic-treatment-for-malaria-a-plausible-approach-to-overcome-artemisinin-combination-therapy-resistance
#17
Nethravathi Puttappa, Raman Suresh Kumar, Karthik Yamjala
Malaria is one of the major global health challenge with 300 million new cases annually. The best regimen for treating Plasmodium falciparum induced malaria is based on artemisinin and its derivatives which were prescribed as artemisinin combination therapy (ACT). These are highly effective drugs resulting in rapid clearance of parasites even in severe P. falciparum induced malaria patients. However, from the past few years parasites resistant to ACT's have begun to emerge in various parts of the world such as Cambodia and Greater Mekong Subregion...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29149993/label-free-determination-of-prostate-specific-membrane-antigen-in-human-whole-blood-at-nanomolar-levels-by-magnetically-assisted-surface-enhanced-raman-spectroscopy
#18
Zuzana Chaloupková, Anna Balzerová, Jitka Bařinková, Zdenka Medříková, Pavel Šácha, Petr Beneš, Václav Ranc, Jan Konvalinka, Radek Zbořil
Prostate cancer is one of the most common cancers among men and can in its later stages cause serious medical problems. Due to the limited suitability of current diagnostic biochemical markers, new biomarkers for the detection of prostate cancer are highly sought after. An ideal biomarker should serve as a reliable prognostic marker, be applicable for early diagnosis, and be applicable for monitoring of therapeutic response. One potential candidate is glutamate carboxypeptidase II (GCPII), also known as prostate specific membrane antigen (PSMA), which has a promising role for direct imaging...
January 2, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29149992/a-separable-surface-enhanced-raman-scattering-substrate-modified-with-mil-101-for-detection-of-overlapping-and-invisible-compounds-after-thin-layer-chromatography-development
#19
Bin Bin Zhang, Yi Shi, Hui Chen, Qing Xia Zhu, Feng Lu, Ying Wei Li
By coupling surface-enhanced Raman spectroscopy (SERS) with thin-layer chromatography (TLC), a powerful method for detecting complex samples was successfully developed. However, in the TLC-SERS method, metal nanoparticles serving as the SERS-active substrate are likely to disturb the detection of target compounds, particularly in overlapping compounds after TLC development. In addition, the SERS detection of compounds that are invisible under both visible light and UV254/365 after TLC development is still a significant challenge...
January 2, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29149638/roles-of-n-and-c-terminal-domains-in-the-ligand-binding-properties-of-cytoglobin
#20
Shumpei Hanai, Hirofumi Tsujino, Taku Yamashita, Ryo Torii, Hitomi Sawai, Yoshitsugu Shiro, Koji Oohora, Takashi Hayashi, Tadayuki Uno
Cytoglobin (Cygb) is a member of the hexacoordinated globin protein family and is expressed ubiquitously in rat and human tissues. Although Cygb is reportedly upregulated under hypoxic conditions both in vivo and in vitro, suggesting a physiological function to protect cells under hypoxic/ischemic conditions by scavenging reactive oxygen species or by signal transduction, the mechanisms associated with this function have not been fully elucidated. Recent studies comparing Cygbs among several species suggest that mammalian Cygbs show a distinctly longer C-terminal domain potentially involved in unique physiological functions...
November 9, 2017: Journal of Inorganic Biochemistry
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