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https://www.readbyqxmd.com/read/29933059/immunomodulatory-and-enhanced-antitumor-activity-of-a-modified-thymosin-%C3%AE-1-in-melanoma-and-lung-cancer
#1
Fanwen Wang, Bin Li, Pengcheng Fu, Qingqing Li, Heng Zheng, Xingzhen Lao
Tumor-targeted therapy is an attractive strategy for cancer treatment. Peptide hormone thymosin α1 (Tα1) has been used against several diseases, including cancer, but its activity is pleiotropic. Herein, we designed a fusion protein Tα1-iRGD by introducing the tumor homing peptide iRGD to Tα1. Results show that Tα1-iRGD can promote T-cell activation and CD86 expression, thereby exerting better effect and stronger inhibitory against melanoma and lung cancer, respectively, than Tα1 in vivo. These effects are indicated by the reduced densities of tumor vessels and Tα1-iRGD accumulation in tumors...
June 19, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29932505/physiological-culture-conditions-alter-myotube-morphology-and-responses-to-atrophy-treatments-implications-for-in-vitro-research-on-muscle-wasting
#2
Elodie Archer-Lahlou, Cathy Lan, R Thomas Jagoe
Standard in vitro myotube culture conditions are nonphysiological and there is increasing evidence that this may distort adaptations to both catabolic and anabolic stimuli and hamper preclinical research into mechanisms and treatments for muscle atrophy in cancer and other chronic diseases. We tested a new model of myotube culture which mimics more accurately the basal conditions for muscle tissue in patients with chronic disease, such as cancer. Myotubes derived from C2C12 myoblasts, cultured under the modified conditions were thinner, more numerous, with more uniform morphology and an increased proportion of mature myotubes...
June 2018: Physiological Reports
https://www.readbyqxmd.com/read/29932254/long-term-immunosuppression-for-cns-mouse-xenotransplantation-effects-on-nigrostriatal-neurodegeneration-and-neuroprotective-carotid-body-cell-therapy
#3
Javier Villadiego, Sonia Romo-Madero, Roberto García-Swinburn, Nela Suárez-Luna, Alfonso Bermejo-Navas, Miriam Echevarría, Juan J Toledo-Aral
BACKGROUND: The use of long-term immunosuppressive treatments on neural transplantation has been controversial during the last decades. Although nowadays there is a consensus about the necessity of maintaining a permanent state of immunosuppression to preserve the survival of cerebral grafts, little is known about the effects that chronic immunosuppression produces both on the neurodegenerative process and on transplants function. METHODS: Here, we establish a new immunosuppressive protocol, based on the discontinuous administration of CsA (15 mg/kg; s...
June 22, 2018: Xenotransplantation
https://www.readbyqxmd.com/read/29932210/follistatin-like-protein-1-induction-of-matrix-metalloproteinase-1-3-and-13-gene-expression-in-rheumatoid-arthritis-synoviocytes-requires-mapk-jak-stat3-and-nf-%C3%AE%C2%BAb-pathways
#4
Su Ni, Chenkai Li, Nanwei Xu, Xi Liu, Wei Wang, Wenyang Chen, Yuji Wang, Andre J van Wijnen
Elevated levels of follistatin-like protein 1 (FSTL1) have been found both in mouse models for human rheumatoid arthritis (RA) and collagen-induced arthritis (CIA). In this study, we elucidated the potential mechanisms by which FSTL1 contributes to the pathogenesis of RA. Fibroblast-like synoviocytes (FLSs) were established from synovial tissues of RA patients and stimulated with human recombinant FSTL1. Protein and mRNA expression levels of select matrix metalloproteinases (i.e., MMP1, MMP3, MMP13) in FLS were measured by, respectively, real-time RT-qPCR and ELISA...
June 22, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29932151/sirnas-targeting-growth-factor-receptor-and-anti-apoptotic-genes-synergistically-kill-breast-cancer-cells-through-inhibition-of-mapk-and-pi-3-kinase-pathways
#5
Nur Izyani Kamaruzman, Snigdha Tiash, Maeirah Ashaie, Ezharul Hoque Chowdhury
Breast cancer, the second leading cause of female deaths worldwide, is usually treated with cytotoxic drugs, accompanied by adverse side-effects, development of chemoresistance and relapse of disease condition. Survival and proliferation of the cancer cells are greatly empowered by over-expression or over-activation of growth factor receptors and anti-apoptotic factors. Identification of these key players that cross-talk to each other, and subsequently, knockdown with their respective siRNAs in a synchronous manner could be a promising approach to precisely treat the cancer...
June 22, 2018: Biomedicines
https://www.readbyqxmd.com/read/29932012/choroideremia-molecular-mechanisms-and-development-of-aav-gene-therapy
#6
Maria I Patrício, Alun R Barnard, Kanmin Xue, Robert E MacLaren
INTRODUCTION: Choroideremia is an X-linked inherited retinal degeneration that causes blindness in afflicted males by middle age. The causative gene, CHM, plays a key role in intracellular trafficking pathways, and its disruption impairs cell homeostasis. Areas covered: The mechanism by which mutations in CHM cause choroideremia is still under debate. Here we describe the molecular defects in choroideremia cells regarding both the deficiency of prenylation and the involvement of Rab GTPases...
June 22, 2018: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29931586/identification-of-ca-2-signaling-components-in-neural-stem-progenitor-cells-during-differentiation-into-neurons-and-glia-in-intact-and-dissociated-zebrafish-neurospheres
#7
Man Kit Tse, Ting Shing Hung, Ching Man Chan, Tiffany Wong, Mike Dorothea, Catherine Leclerc, Marc Moreau, Andrew L Miller, Sarah E Webb
The development of the CNS in vertebrate embryos involves the generation of different sub-types of neurons and glia in a complex but highly-ordered spatio-temporal manner. Zebrafish are commonly used for exploring the development, plasticity and regeneration of the CNS, and the recent development of reliable protocols for isolating and culturing neural stem/progenitor cells (NSCs/NPCs) from the brain of adult fish now enables the exploration of mechanisms underlying the induction/specification/differentiation of these cells...
June 20, 2018: Science China. Life Sciences
https://www.readbyqxmd.com/read/29930803/stevens-johnsons-syndrome-or-drug-induced-lupus-a-clinical-dilemma-a-case-report-and-review-of-the-literature
#8
Violeta Claudia Bojinca, Mihai Bojinca, Madalina Gheorghe, Adelina Birceanu, Cristina Ileana Iosif, Serban Mihai Balanescu, Andra Rodica Balanescu
Tumor necrosis factor inhibitors are the first biological agents used in the treatment of rheumatoid arthritis (RA) to have yielded satisfactory results in terms of clinical improvement and radiologic progression, but they are also associated with the possibility of occurrence of a number of autoimmune systemic events [drug-induced lupus (DIL), vasculitis, sarcoidosis] and localized adverse events [uveitis, psoriasis, interstitial lung disease, erythema multiforme including the major form Stevens-Johnson syndrome (SJS)]...
July 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29930759/wnk1-kinase-and-its-partners-akt-sgk1-and-nbc-family-na-hco3-cotransporters-are-potential-therapeutic-targets-for-glioblastoma-stem-like-cells-linked-to-bisacodyl-signaling
#9
Wanyin Chen, Leonel Nguekeu Zebaze, Jihu Dong, Laëtitia Chézeau, Perrine Inquimbert, Sylvain Hugel, Songlin Niu, Fréderic Bihel, Emmanuel Boutant, Eléonore Réal, Pascal Villa, Marie-Pierre Junier, Hervé Chneiweiss, Marcel Hibert, Jacques Haiech, Marie-Claude Kilhoffer, Maria Zeniou
Glioblastoma is a highly heterogeneous brain tumor. The presence of cancer cells with stem-like and tumor initiation/propagation properties contributes to poor prognosis. Glioblastoma cancer stem-like cells (GSC) reside in hypoxic and acidic niches favoring cell quiescence and drug resistance. A high throughput screening recently identified the laxative Bisacodyl as a cytotoxic compound targeting quiescent GSC placed in acidic microenvironments. Bisacodyl activity requires its hydrolysis into DDPM, its pharmacologically active derivative...
June 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29930161/early-proteinuria-lowering-by-angiotensin-converting-enzyme-inhibition-predicts-renal-survival-in-children-with-ckd
#10
Sophie M van den Belt, Hiddo J L Heerspink, Valentina Gracchi, Dick de Zeeuw, Elke Wühl, Franz Schaefer
Background Although pharmacotherapeutic proteinuria lowering was found to be nephroprotective in adults, the predictive value of early drug-induced proteinuria reduction for long-term renal survival in pediatric CKD is unknown. We analyzed data from the ESCAPE Trial for a potential association between initial antiproteinuric effect of standardized angiotensin-converting enzyme (ACE) inhibition and renal disease progression in children with CKD. Methods In total, 280 eligible children with CKD stages 2-4 (mean age 11...
June 21, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29929736/malignancy-development-risk-in-psoriatic-arthritis-patients-undergoing-treatment-a-systematic-review-and-meta-analysis
#11
REVIEW
Xuan Luo, Chuiwen Deng, Yunyun Fei, Wen Zhang, Yongzhe Li, Xuan Zhang, Yan Zhao, Xiaofeng Zeng, Fengchun Zhang
BACKGROUND: Psoriatic arthritis (PsA) is a chronic and seronegative inflammatory arthritis occurring in patients with psoriasis. The current knowledge about the risk of malignancy associated with psoriatic arthritis (PsA) patients undergoing therapy is controversial. We focused on the relationship between malignancy and therapy and undertook a meta-analysis to address this issue. METHODS: A systematic literature search of the PubMed, EMBASE, and Web of Science databases was performed to identify relevant studies and trials...
May 23, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29928978/dual-functional-lipid-polymeric-hybrid-ph-responsive-nanoparticles-decorated-with-cell-penetrating-peptide-and-folate-for-therapy-against-rheumatoid-arthritis
#12
Jinlong Zhao, Xueyan Zhang, Xiangshi Sun, Menghui Zhao, Changhui Yu, Robert J Lee, Fengying Sun, Yulin Zhou, Youxin Li, Lesheng Teng
Methotrexate (MTX), as a disease modifying antirheumatic drug (DMARD), was first line drug to treat rheumatoid arthritis. However, the severe side effect during long term and high dosage usage limit its application. The aim of this study was to develop dual-functional lipid polymeric hybrid pH-responsive nanoparticles to deliver MTX to inflamed joints selectively. The designed MTX loaded stearic acid-octa-arginine and folic acid decorated poly lactic-co-glycolic acid (PLGA) -PK3-based lipid polymeric hybrid nanoparticles (Sta-R8-FA-PPLPNs/MTX) were composed of PK3, Folate-PEG-PLGA, egg PC, and Sta-R8...
June 18, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29928951/higher-serum-levels-of-pro-hepcidin-in-patients-with-parkinson-s-disease-treated-with-deep-brain-stimulation
#13
J Kwiatek-Majkusiak, M Geremek, D Koziorowski, R Tomasiuk, S Szlufik, A Friedman
Hepcidin is an essential hormone responsible for the systemic metabolism of iron and simultaneously belongs to the family of the protein mediators of the acute inflammatory response, primarily induced in response to interleukin 6. It can therefore be regarded as a link between the oxidative stress processes, where iron plays an important role, and the processes of neuroinflammation - both considered to be responsible for the neurodegeneration in Parkinson's disease. We assessed the serum level of pro-hepcidin in patients with Parkinson's disease treated only pharmacologically and those treated additionally with deep brain stimulation (DBS) as compared to the control group...
June 18, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29928645/bile-cast-nephropathy-the-unknown-dangers-of-online-shopping
#14
Andrea Fisler, Tobias Breidthardt, Nadine Schmidlin, Helmut Hopfer, Michael Dickenmann, Katrin König, Patricia Hirt-Minkowski
Renal dysfunction in the setting of cholestatic liver disease is multifactorial but most often due to decreased kidney perfusion from intravascular volume depletion, acute tubular injury/necrosis, and hepatorenal syndrome. Drug-induced hepatotoxicity may be associated with a cholestatic injury pattern. We report a case of a 56-year-old man with a diagnosis of bile cast nephropathy, as a complication of drug-induced severe hyperbilirubinemia due to the abuse of intramuscular anabolic steroids bought on the internet to increase muscular mass for bodybuilding training...
May 2018: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/29928608/recent-advances-in-nanoparticle-carriers-for-photodynamic-therapy
#15
REVIEW
Gawon Yi, Suk Ho Hong, Jihwan Son, Jihye Yoo, Changhee Park, Yongdoo Choi, Heebeom Koo
This review summarizes recent advances in the development of nanoparticles (NPs) for efficient photodynamic therapy (PDT), particularly the development and application of various NPs based on organic and inorganic materials. PubMed database was used for literature search with the terms including NP, nanomedicine, PDT, photosensitizer (PSs), and drug delivery. For successful PDT, it is essential to deliver PSs to target disease sites. A number of NPs have been developed and tested as the carriers for both imaging and therapy, an approach termed "nanomedicine"...
May 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29928007/a-cytokine-protein-protein-interaction-network-for-identifying-key-molecules-in-rheumatoid-arthritis
#16
Venugopal Panga, Srivatsan Raghunathan
Rheumatoid arthritis (RA) is a chronic inflammatory disease of the synovial joints. Though the current RA therapeutics such as disease-modifying antirheumatic drugs (DMARDs), nonsteroidal anti-inflammatory drugs (NSAIDs) and biologics can halt the progression of the disease, none of these would either dramatically reduce or cure RA. So, the identification of potential therapeutic targets and new therapies for RA are active areas of research. Several studies have discovered the involvement of cytokines in the pathogenesis of this disease...
2018: PloS One
https://www.readbyqxmd.com/read/29927982/influenza-d-virus-m2-protein-exhibits-ion-channel-activity-in-xenopus-laevis-oocytes
#17
Evan Kesinger, Jianing Liu, Aaron Jensen, Catherine P Chia, Andrew Demers, Hideaki Moriyama
BACKGROUND: A new type of influenza virus, known as type D, has recently been identified in cattle and pigs. Influenza D virus infection in cattle is typically asymptomatic; however, its infection in swine can result in clinical disease. Swine can also be infected with all other types of influenza viruses, namely A, B, and C. Consequently, swine can serve as a "mixing vessel" for highly pathogenic influenza viruses, including those with zoonotic potential. Currently, the only antiviral drug available targets influenza M2 protein ion channel is not completely effective...
2018: PloS One
https://www.readbyqxmd.com/read/29927820/acetyl-11-keto-%C3%AE-boswellic-acid-promotes-osteoblast-differentiation-by-inhibiting-tumor-necrosis-factor-%C3%AE-and-nuclear-factor-%C3%AE%C2%BAb-activity
#18
Fan Bai, Xuewu Chen, Hui Yang, Hong-Guang Xu
Tumor necrosis factor (TNF) -α plays a crucial role in rheumatoid arthritis (RA)-related bone loss disease. The main mechanism of action of RA induced bone loss is the significant inhibitory effect of TNF-α on osteoblast differentiation. TNF-α inhibits osteoblast differentiation mainly by activating nuclear factor (NF) -κB signaling pathway. Owing to the crucial role of TNF-α and NF-κB in the inhibition of osteoblast differentiation, they are considered as targets for the development of therapeutic drugs...
June 20, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29927684/inhibition-of-the-histone-demethylase-kdm4b-leads-to-activation-of-kdm1a-attenuates-bacterial-induced-pro-inflammatory-cytokine-release-and-reduces-osteoclastogenesis
#19
Joy E Kirkpatrick, Keith L Kirkwood, Patrick M Woster
Periodontal disease (PD) afflicts 46% of Americans with no effective adjunctive therapies available. While most pharmacotherapy for PD targets bacteria, the host immune response is responsible for driving tissue damage and bone loss in severe disease. Herein, we establish that the histone demethylase KDM4B is a potential drug target for the treatment of PD. Immunohistochemical staining of diseased periodontal epithelium revealed an increased abundance of KDM4B that correlates with inflammation. In murine calvarial sections exposed to Aggregatibacter actinomycetemcomitans lipopolysaccharide (Aa-LPS), immunohistochemical staining revealed a significant increase in KDM4B protein expression...
June 21, 2018: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/29927573/neuroprotective-effect-of-tetrahedral-dna-nanostructures-in-a-cell-model-of-alzheimer-s-disease
#20
Xiao-Ru Shao, Wen-Juan Ma, Xue-Ping Xie, Qian-Shun Li, Shi-Yu Lin, Tao Zhang, Yun-Feng Lin
Accumulating evidence supports the abnormal deposition of amyloid beta-peptide (Aβ) as the main cause of Alzheimer's disease (AD). Therefore, fighting against the formation, deposition, and toxicity of Aβ is a basic strategy for the treatment of AD. In the process of in vitro nerve cell culture, screening out drugs that can antagonize a series of toxic reactions caused by β-amyloid deposition has become an effective method for the follow-up treatment of AD. Our previous studies showed that tetrahedral DNA nanostructures (TDNs) had good biocompatibility and had some positive effects on the biological behavior of cells...
June 21, 2018: ACS Applied Materials & Interfaces
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