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https://www.readbyqxmd.com/read/30022903/awareness-of-cervical-cancer-among-women-in-malaysia
#1
Lee Mun Seng, Aina Najwa Rosman, Almas Khan, Najwa Md Haris, Nur Alyan Syahmi Mustapha, Nur Sakina Muhammad Husaini, Nurul Fadhilah Zahari
Objectives: The purpose of this study is to evaluate and ascertain the current knowledge, perception, level of awareness, and attitudes toward cervical cancer (CC) among women in Malaysia. Methods: A cross-sectional study was conducted which involved 210 women aged between 21 and 60 years old at the public in Malaysia, a subsequent statistical analysis was performed by SPSS version 22. Results: In comparison with other studies, there is still lacking of awareness on CC and these induced informal cluelessness and poor attitudes toward it...
July 2018: International Journal of Health Sciences
https://www.readbyqxmd.com/read/30021700/community-based-hiv-prevalence-in-kwazulu-natal-south-africa-results-of-a-cross-sectional-household-survey
#2
Ayesha B M Kharsany, Cherie Cawood, David Khanyile, Lara Lewis, Anneke Grobler, Adrian Puren, Kaymarlin Govender, Gavin George, Sean Beckett, Natasha Samsunder, Savathree Madurai, Carlos Toledo, Zawadi Chipeta, Mary Glenshaw, Sara Hersey, Quarraisha Abdool Karim
BACKGROUND: In high HIV burden settings, maximising the coverage of prevention strategies is crucial to achieving epidemic control. However, little is known about the reach and effect of these strategies in some communities. METHODS: We did a cross-sectional community survey in the adjacent Greater Edendale and Vulindlela areas in the uMgungundlovu district, KwaZulu-Natal, South Africa. Using a multistage cluster sampling method, we randomly selected enumeration areas, households, and individuals...
July 13, 2018: Lancet HIV
https://www.readbyqxmd.com/read/30020453/the-epidemiology-of-herpes-simplex-virus-type-1-in-asia-systematic-review-meta-analyses-and-meta-regressions
#3
Lara Khadr, Manale Harfouche, Ryosuke Omori, Guido Schwarzer, Hiam Chemaitelly, Laith J Abu-Raddad
Objective: To characterize herpes simplex virus type 1 (HSV-1) epidemiology in Asia by assessing seroprevalence levels and extent to which HSV-1 is isolated from clinically-diagnosed genital ulcer disease (GUD) and genital herpes. Methods: HSV-1 reports in Asia were systematically reviewed and synthesized, and findings reported following PRISMA guidelines. Random-effects meta-analyses were conducted to estimate pooled mean seroprevalence and proportion of HSV-1 detection in GUD and genital herpes...
July 18, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/30019769/lefamulin-review-of-a-promising-novel-pleuromutilin-antibiotic
#4
Michael P Veve, Jamie L Wagner
The emergence and spread of antimicrobial resistance has led to a global public health emergency requiring development of new antimicrobial classes. Lefamulin (formally BC-3781) is a novel pleuromutilin antibiotic currently undergoing Food and Drug Administration review for community-acquired bacterial pneumonia (CABP) as intravenous (IV) and oral (PO) formulations. While pleuromutilin antibiotics were first developed in the 1950s, lefamulin is the first to be used for systemic treatment of bacterial infections in humans...
July 18, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/30018648/-not-my-child-parents-denial-about-adolescent-sexuality-in-harare-zimbabwe
#5
Manase Chiweshe, Malvern Chiweshe
Objective: To find out adult views on adolescent sexualities in Zimbabwe and how adults construct sexual cultures that deny adolescence access to sex. Materials and methods: The paper uses qualitative methodologies, with purposively selected parents and key informants. A total of ten in depth interviews, four focus groups and six key informant interviews with purposively sampled male and female respondents were conducted. Key informants included a headmaster, teacher, social worker, nurses and a member of traditional healers association...
September 2017: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/30017717/sexual-health-knowledge-of-u-s-medical-students-a-national-survey
#6
Christina Warner, Samantha Carlson, Renee Crichlow, Michael W Ross
BACKGROUND: Sexual health is a critical component of overall wellness; however, only half of U.S. medical schools currently require formal instruction in sexuality. AIM: This study sought to quantify the sexual health knowledge of undergraduate medical students using a novel survey tool evaluating 6 domains: sexual function and dysfunction; fertility and reproduction; sexuality across the lifespan; sexual minority health; society, culture, and behavior; as well as safety and prevention...
July 12, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/30016998/sex-gap-in-aging-and-longevity-can-sex-chromosomes-play-a-role
#7
REVIEW
Gabriel A B Marais, Jean-Michel Gaillard, Cristina Vieira, Ingrid Plotton, Damien Sanlaville, François Gueyffier, Jean-Francois Lemaitre
It is well known that women live longer than men. This gap is observed in most human populations and can even reach 10-15 years. In addition, most of the known super centenarians (i.e., humans who lived for > 110 years) are women. The differences in life expectancy between men and women are often attributed to cultural differences in common thinking. However, sex hormones seem to influence differences in the prevalence of diseases, in the magnitude of aging, and in the longevity between men and women...
July 17, 2018: Biology of Sex Differences
https://www.readbyqxmd.com/read/30009141/review-of-trichomonas-vaginalis-in-iran-based-on-epidemiological-situation
#8
REVIEW
Mohsen Arbabi, Mahdi Delavari, Zohreh Fakhrieh-Kashan, Hossein Hooshyar
Trichomoniasis, which is caused by Trichomonas vaginalis , is the most common non-viral sexually transmitted infection (STI) in the world including Iran. There were roughly 250 million new cases all over the world in a year. T. vaginalis as an important disease has been associated with HIV (in terms of exposure to sexually transmitted infection, STI) which increases the number of high-risk members, and thus it is an important public health problem. Additionally, this pathogen has been associated with serious health consequences...
April 2018: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/30006789/retroviruses-and-reproduction-revisited
#9
Ann A Kiessling
Thanks to effective anti-HIV medications, deaths from acquired immunodeficiency disease (AIDS) have plummeted, although the incidence of new HIV infections has decreased little, approximately 36,000 annually in the USA. The CDC estimates 1.1 million persons, mostly men, are living with HIV in the USA, with approximately 14% unaware they are infected. Since the global blood supply is essentially free of HIV today, infected semen is fueling the pandemic (88% of new infections in the USA), with needle sharing among IV drug abusers (7% of new US infections) and female to male transmission (5% of new infections) accounting for the balance...
July 13, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/30003923/mathematical-analysis-of-the-role-of-hospitalization-isolation-in-controlling-the-spread-of-zika-fever
#10
Mudassar Imran, Muhammad Usman, Tufail Malik, Ali R Ansari
The Zika virus is transmitted to humans primarily through Aedes mosquitoes and through sexual contact. It is documented that the virus can be transmitted to newborn babies from their mothers. We consider a deterministic model for the transmission dynamics of the Zika virus infectious disease that spreads in, both humans and vectors, through horizontal and vertical transmission. The total populations of both humans and mosquitoes is assumed to be constant. Our models consist of a system of eight differential equations describing the human and vector populations during the different stages of the disease...
July 9, 2018: Virus Research
https://www.readbyqxmd.com/read/30003068/characterization-of-jak2-v617f-1849-g-t-mutation-in-cervical-cancer-related-to-human-papillomavirus-and-sexually-transmitted-infections
#11
Masoumeh Abdolmaleki, Amir Sohrabi
Background: Human papillomavirus (HPV) genotypes that infect the genital tract play a main etiologic role in cervical cancer progression. Other environmental factors, such as sexually transmitted diseases and the host genetic pattern, contribute to infection persistence of the uterus and cervical epithelium in sustaining their malignancy. The Janus kinase 2 is a non-receptor tyrosine kinase in cell signaling process of tumor genesis. In the present study, JAK2 V167F mutation was distinguished in women with sexually transmitted infections, such as Herpes simplex virus 2, Chlamydia trachomatis and Mycoplasma genitalium and cervical cancer...
June 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/30002845/chlamydia-protein-pgp3-studied-at-high-resolution-in-a-new-crystal-form
#12
Sahir Khurshid, Lata Govada, Gillian Wills, Myra O McClure, John R Helliwell, Naomi E Chayen
The protein Pgp3 is implicated in the sexually transmitted disease chlamydia and comprises an extended complex arrangement of a C-terminal domain (CTD) and an N-terminal domain (NTD) linked by a triple-helix coiled coil (THCC). Here, the X-ray crystal structure of Pgp3 from an LGV1 strain is reported at the highest X-ray diffraction resolution obtained to date for the full protein. The protein was crystallized using a high concentration of potassium bromide, which resulted in a new crystal form with relatively low solvent content that diffracted to a resolution of 1...
July 1, 2018: IUCrJ
https://www.readbyqxmd.com/read/30002834/an-unusual-cause-of-adrenal-insufficiency-and-bilateral-adrenal-masses
#13
Su Ann Tee, Earn Hui Gan, Mohamad Zaher Kanaan, David Ashley Price, Tim Hoare, Simon H S Pearce
Primary adrenal insufficiency secondary to syphilis is extremely rare, with only five cases being reported in the literature. We report a case of adrenal insufficiency as a manifestation of Treponema pallidum infection (tertiary syphilis). A 69-year-old, previously fit and well Caucasian male was found to have adrenal insufficiency after being admitted with weight loss, anorexia and postural dizziness resulting in a fall. Biochemical testing showed hyponatraemia, hyperkalaemia, and an inadequate response to Synacthen testing, with a peak cortisol level of 302 nmol/L after administration of 250 µg Synacthen...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/30001298/hiv-coinfection-among-persons-diagnosed-as-having-sexually-transmitted-diseases-san-francisco-2007-to-2014
#14
Miao-Jung Chen, Susan Scheer, Trang Q Nguyen, Robert P Kohn, Sandra K Schwarcz
BACKGROUND: Early syphilis, gonorrhea, and chlamydia but not HIV infections have increased in San Francisco, primarily among men. METHODS: We linked records of persons reported with early syphilis, gonorrhea, and chlamydia to records of persons reported with HIV to measure the proportion and characteristics of San Francisco residents with HIV-sexually transmitted disease (STD) coinfection between 2007 and 2014. We measured trends in HIV coinfection separately for men and women for each STD...
August 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/30001297/state-laws-related-to-billing-third-parties-for-health-care-services-at-public-sexually-transmitted-disease-clinics-in-the-united-states
#15
Ryan Cramer, Penny S Loosier, Andee Krasner, Jennifer Kawatu
BACKGROUND: Health departments (HDs) cite state laws as barriers to billing third parties for sexually transmitted disease (STD) services, but the association between legal/policy barriers and third-party HD billing has not been examined. This study investigates the relationship between laws that may limit HDs' ability to bill, clinic perceptions of billing barriers, and billing practices. METHODS: Two surveys, (1) clinic managers (n = 246), (2) STD program managers (n = 63), conducted via a multiregional needs assessment of federally funded HD clinics' capacity to bill for STD services, billing/reimbursement practices, and perceived barriers were combined with an analysis of state laws regarding third-party billing for STD services...
August 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29996927/prevalence-of-anti-hepatitis-c-antibodies-and-its-co-infection-with-hiv-in-rural-cameroon
#16
Valirie Ndip Agbor, Claude Tayou Tagny, Jules-Bertrand Kenmegne, Bih Awazi, Charlotte Ngansop, Dora Mbanya, Nicaise Ndembi
OBJECTIVE: To evaluate the prevalence of the co-infection between the human immunodeficiency virus (HIV) and hepatitis C virus (HCV), and the prevalence of factors associated with HCV transmission in a rural Cameroonian community. RESULTS: The mean age of the 174 participants included in the study was 30.3 (standard deviation = 13.26) years (age range 12-77 years). the prevalence of HCV/HIV co-infection was 1.7% [95% confidence interval (CI) 1.1-5.9]. The prevalence of HCV and HIV were 6...
July 11, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29994936/survey-of-obstetrician-gynecologists-in-the-united-states-about-trichomoniasis-2016
#17
Eugene W Liu, Kimberly A Workowski, Laura Taouk, Jay Schulkin, William E Secor, Jeffrey L Jones
PURPOSE: Trichomoniasis is the most prevalent non-viral sexually transmitted infection in the United States. It can present with vaginitis in women and urethritis in men, but is most often asymptomatic or occurs with minimal symptoms. It is associated with other sexually transmitted infections (STIs), adverse pregnancy outcomes and pelvic inflammatory disease. For these reasons, healthcare provider awareness of trichomoniasis is of public health importance. METHODS: To assess practitioner knowledge, attitudes, and practices concerning trichomoniasis management, the American College of Obstetricians and Gynecologists (ACOG) conducted an online survey in 2016 of its members, and we analyzed results from 230 respondents...
July 7, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29989879/unusual-manifestations-of-secondary-syphilis-case-presentations
#18
Sorina Ana Dănescu, Blanca Szolga, Carmen Georgiu, Alina Surcel, Simona Corina Corina Șenilă
Dear Editor, Syphilis is an infection caused by Treponema pallidum. Without treatment, it goes through the following stages: primary, secondary, latent, and tertiary (1). The clinical picture of secondary syphilis is very variable (2,3). We present two rare cases of secondary syphilis, one with nodular lesions initially considered to be lymphoma and second with periostitis, which was initially interpreted as an osteoma. To date, only 15 cases with nodular lesions and 10 cases with periostitis in secondary syphilis have been reported in the literature...
June 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29983342/advancing-the-public-health-applications-of-chlamydia-trachomatis-serology
#19
REVIEW
Sarah C Woodhall, Rachel J Gorwitz, Stephanie J Migchelsen, Sami L Gottlieb, Patrick J Horner, William M Geisler, Catherine Winstanley, Katrin Hufnagel, Tim Waterboer, Diana L Martin, Wilhelmina M Huston, Charlotte A Gaydos, Carolyn Deal, Magnus Unemo, J Kevin Dunbar, Kyle Bernstein
Genital Chlamydia trachomatis infection is the most commonly diagnosed sexually transmitted infection. Trachoma is caused by ocular infection with C trachomatis and is the leading infectious cause of blindness worldwide. New serological assays for C trachomatis could facilitate improved understanding of C trachomatis epidemiology and prevention. C trachomatis serology offers a means of investigating the incidence of chlamydia infection and might be developed as a biomarker of scarring sequelae, such as pelvic inflammatory disease...
July 5, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29981756/impacts-of-infection-avoidance-for-populations-affected-by-sexually-transmitted-infections
#20
Michal Theuer, Luděk Berec
Sexually transmitted infections are ubiquitous in nature and affect many populations. The key process for their transmission is mating, usually preceded by mate choice. Susceptible individuals may avoid mating with infected individuals to prevent infection provided it is recognizable. We show that accounting for infection avoidance significantly alters host population dynamics. We observe bistability between the disease-free and endemic or disease-induced extinction equilibria, significant abrupt reduction in the host population size and disease-induced host extinction...
July 5, 2018: Journal of Theoretical Biology
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