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endometrial intraepithelial neoplasia

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https://www.readbyqxmd.com/read/27910065/pathology-of-endometrial-carcinoma
#1
Sigurd F Lax
On a clinicopathological and molecular level, two distinctive types of endometrial carcinoma, type I and type II, can be distinguished. Endometrioid carcinoma, the typical type I carcinoma, seems to develop through an estrogen-driven "adenoma carcinoma" pathway from atypical endometrial hyperplasia/endometrioid intraepithelial neoplasia (AEH/EIN). It is associated with elevated serum estrogen and high body mass index and expresses estrogen and progesterone receptors. They are mostly low grade and show a favorable prognosis...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27902476/stromal-p16-expression-is-significantly-increased-in-endometrial-carcinoma
#2
Gun Yoon, Chang Won Koh, Nara Yoon, Ji-Ye Kim, Hyun-Soo Kim
p16 is a negative regulator of cell proliferation and is considered a tumor suppressor protein. Alterations in p16 protein expression are associated with tumor development and progression. However, the p16 expression status in the peritumoral stroma has not been investigated in the endometrium. Therefore, we evaluated stromal p16 expression in different types of endometrial lesions using immunohistochemistry. Differences in the p16 expression status according to the degree of malignancy and histological type were analyzed...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27901412/oral-progestogens-versus-levonorgestrel-releasing-intrauterine-system-for-treatment-of-endometrial-intraepithelial-neoplasia
#3
Mary L Marnach, Kristina A Butler, Michael R Henry, Catherine E Hutz, Carrie L Langstraat, Christine M Lohse, Petra M Casey
BACKGROUND: Limited therapeutic guidelines exist regarding medical therapy, ideal dosing, duration of therapy, or recommendations for timing of endometrial reassessment for women with endometrial intraepithelial neoplasia (EIN) who desire fertility preservation or who are not optimal surgical candidates. We aimed to determine the effectiveness of oral progestogens (OP) versus the levonorgestrel-releasing intrauterine system (LNG IUS) in the medical treatment of EIN. METHODS: We retrospectively identified women with EIN at our institution from 2007 through 2014 and compared the outcomes of those treated with OP versus LNG IUS...
November 30, 2016: Journal of Women's Health
https://www.readbyqxmd.com/read/27738815/-new-features-in-the-2014-who-classification-of-uterine-neoplasms
#4
S F Lax
The 2014 World Health Organization (WHO) classification of uterine tumors revealed simplification of the classification by fusion of several entities and the introduction of novel entities. Among the multitude of alterations, the following are named: a simplified classification for precursor lesions of endometrial carcinoma now distinguishes between hyperplasia without atypia and atypical hyperplasia, the latter also known as endometrioid intraepithelial neoplasia (EIN). For endometrial carcinoma a differentiation is made between type 1 (endometrioid carcinoma with variants and mucinous carcinoma) and type 2 (serous and clear cell carcinoma)...
October 13, 2016: Der Pathologe
https://www.readbyqxmd.com/read/27601118/the-histological-significance-of-atypical-glandular-cells-on-cervical-cytology-experience-at-groote-schuur-hospital-cape-town-south-africa
#5
Lance D Hoffman, Hue-Tsi Wu
BACKGROUND: Atypical glandular cells (AGC) identified on Pap tests may be markers for potentially significant pathology. OBJECTIVES: Primarily, to correlate AGC findings at Groote Schuur Hospital (GSH, Cape Town, South Africa) with subsequent histological investigations and attempt to identify predictors of pathology relevant to the clinical management of women with a cytological diagnosis of AGC. Secondly, to compare the GSH data with data from similar international studies...
August 4, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27465834/cervical-polyps-is-histologic-evaluation-necessary
#6
Rebecca A Levy, Asangi R Kumarapeli, Horace J Spencer, Charles M Quick
OBJECTIVE: The aim of this study was to examine a series of clinically identified cervical polyps and determine the incidence of significant histologic and concurrent cytologic findings. METHODS: Consecutive cervical polyps from January 2000 through September 2012 were retrieved from the hospital laboratory information system. Histologic evaluation of these polyps was performed, followed by a chart review of clinical findings and correlation with the immediately prior or concurrently collected cervical Papanicolaou (Pap) test results, when available...
September 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27347120/human-wings-apart-like-gene-is-specifically-overexpressed-in-cervical-cancer
#7
Xiaoqin Lu, Jinquan Cui, Meizhou Fu, Wuliang Wang
Cervical cancer is the third most commonly diagnosed cancer in women. The human wings apart-like (hWAPL) gene, which is 30,793 bp long and located on 10q23.2., is a human homologue of the WAPL gene in Drosophila melanogaster. hWAPL has the characteristics of an oncogene in uterine cervical cancer. The present study investigated the expression of the hWAPL gene in tissues, including 9 common cancers, consisting of cervical, gastric and lung cancers, liver, bladder, esophageal, endometrial, renal and rectal carcinomas, cervical intraepithelial neoplasia (CIN) and benign squamous epithelia...
July 2016: Oncology Letters
https://www.readbyqxmd.com/read/27186853/unusual-mismatch-repair-immunohistochemical-patterns-in-endometrial-carcinoma
#8
Jaclyn C Watkins, Marisa R Nucci, Lauren L Ritterhouse, Brooke E Howitt, Lynette M Sholl
Universal screening for Lynch syndrome through mismatch repair (MMR) immunohistochemistry (IHC) on tumor samples has brought to light several heterogenous MMR staining patterns. At our institution, a prospective study of universal Lynch syndrome screening using MMR IHC on 125 endometrial cancers (EC) led to the identification of subclonal loss of MMR protein expression within the tumor (n=9). We also interrogated the MMR staining patterns in MMR-deficient EC with concurrent endometrial intraepithelial neoplasia (EIN; n=14) and all mixed-type ECs (n=14) to look for concordant or discordant profiles between the various components...
July 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27172639/endometrial-effects-of-prolonged-therapy-with-the-selective-progesterone-receptor-modulator-ulipristal-acetate-a-case-report
#9
Gary Levy, John Elkas, Alicia Y Armstrong, Lynnette K Nieman
BACKGROUND: Prolonged exposure to a selective progesterone receptor modulator (ulipristal acetate) in a patient with benign metastasizing leiomyoma did not result in endometrial hyperplasia or neoplasia. CASE: A woman with history of benign metastasizing leiomyoma underwent medical treatment for 5 years with ulipristal acetate. Endometrial biopsies were performed at established intervals to monitor for intraepithelial neoplasia or progesterone receptor modulator-associated endometrial changes (PAECs)...
March 2016: Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/27146746/abnormal-uterine-cervical-cytology-in-a-large-tertiary-hospital-in-bangkok-metropolis-prevalence-management-and-outcomes
#10
C Kingnate, S Tangjitgamol, J Khunnarong, S Manusirivithaya
OBJECTIVES: To determine the prevalence of abnormal cervical cytology, management, and association with clinical significant histopathology including cervical intraepithelial neoplasia II or adenocarcinoma in situ and more severe lesions. MATERIALS AND METHODS: Women with abnormal cervical cytology from January 2005 to December 2009 were identified from the archives of Department of Anatomical Pathology and Department of Obstetrics and Gynecology. Demographic data, type of abnormal cytology, management, and their associated histopathology were collected...
January 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/27115423/clinical-significance-of-atypical-glandular-cells-in-pap-tests-an-analysis-of-more-than-3000-cases-at-a-large-academic-women-s-center
#11
Dinesh Pradhan, Zaibo Li, Rebecca Ocque, Stell Patadji, Chengquan Zhao
BACKGROUND: The interpretation of atypical glandular cells (AGC) in Papanicolaou (Pap) tests and screening for glandular neoplasia remain challenging. METHODS: Pap tests with an AGC interpretation from January 2008 to December 2013 were retrieved from a pathology database, and cases with histologic follow-up within 1 year were included in the study. RESULTS: There were 589,830 Pap tests during the study period, and 3709 cases (0.6%) were reported as AGC, which included the following: AGC, not otherwise specified (52...
August 2016: Cancer Cytopathology
https://www.readbyqxmd.com/read/27067843/-paradigm-shift-in-ovarian-tumor-pathology-from-the-view-of-genomic-abnormalities
#12
Yoshiki Mikami
A decade of accumulated evidence has led to significant progress and a paradigm shift in ovarian tumor pathology. Now, ovarian carcinoma is widely recognized as a heterogeneous group of neoplasms with regard to histogenesis and underlying molecular mechanisms. Ovarian carcinoma is, therefore, divided into 2 clinicopathologic groups: type 1 and type 2 tumors. Type 1 tumors arise in association with benign neoplastic conditions (adenoma-carcinoma sequence). They include endometriosis-related ovarian neoplasias, such as clear cell carcinoma and low-grade endometrioid carcinoma, which are derived from atypical endometriosis or adenofibroma, as well as mucinous carcinoma and low-grade serous carcinoma, which are commonly associated with mucinous and serous borderline tumors, respectively...
March 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/26972419/the-role-of-immunohistochemical-adrenomedullin-and-bcl-2-expression-in-development-of-type-1-endometrial-adenocarcinoma-adrenomedullin-expression-in-endometrium
#13
Kemal Kürşat Bozkurt, Yakup Yalçın, Ebru Erdemoğlu, Burak Tatar, Evrim Erdemoğlu, Sevim Süreyya Çerçi, İbrahim Metin Çiriş, Şirin Başpınar, Afife Uğuz, Nilgün Kapucuoğlu
BACKGROUND: Adrenomedullin (AM) is a pluripotent peptide first discovered from human pheochromocytoma. AM expression has been shown in various cancer types including endometrium cancer. Bcl-2 is an antiapoptotic protein which might be regulated by AM in hypoxic conditions. The aim of the present study was to investigate the role of AM and Bcl-2 expressions in carcinogenesis of type-1 endometrium cancer. MATERIALS AND METHOD: Study group consisted of 10 proliferative endometrium, 22 simple endometrial hyperplasia, 23 endometrial intraepithelial neoplasia (EIN) and 30 Grade 1 endometrioid adenocarcinoma patients...
May 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/26921623/metal-accumulation-in-the-human-uterus-varies-by-pathology-and-smoking-status
#14
Piotr Rzymski, Przemysław Niedzielski, Paweł Rzymski, Katarzyna Tomczyk, Lidia Kozak, Barbara Poniedziałek
OBJECTIVE: To evaluate the content of Al, Cd, Cr, Cu, Mn, Ni, Pb, and Zn in human endometrium (END), endocervix (ECX), and endometrial (END-P) and endocervical (ECX-P) polyps in relation to histologic image and female demographic characteristics and habits. DESIGN: Tissues were collected during curettage of the uterine cavity, subjected to histopathologic examination, digested, and analyzed with the use of a microwave induced nitrogen plasma atomic emission spectrometer...
June 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/26871687/assessment-of-cervicovaginal-cancer-antigen-125-levels-a-preliminary-study-for-endometrial-cancer-screening
#15
Pinar Calis, Kunter Yuce, Derman Basaran, Coskun Salman
AIM: We primarily aimed to compare the levels of serum and cervicovaginal cancer antigen 125 (CA 125) in women with and without endometrial carcinoma in order to reveal whether cervicovaginal CA 125 could be used as a non-invasive method. METHODS: A preliminary case-control study was designed. The study group consisted of patients who were operated for endometrial adenocarcinoma or endometrial intraepithelial neoplasia. The control group consisted of patients who underwent surgery for benign gynecological diseases...
2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/26838198/high-grade-cervical-histopathology-in-women-with-atypical-glandular-cell-cytology
#16
Waranya Watcharanon, Sanguanchoke Luanratanakorn, Pilaiwan Kleebkaow, Bandit Chumworathayi, Amornrat Temtanakitpaisan, Chumnan Kietpeerakool
This study was undertaken to evaluate the prevalence of underlying significant lesions among women referred for colposcopy after atypical glandular cell (AGC) smears and the associated risks. The present study reviewed data from women with AGC smears undergoing colposcopy at the Colposcopy Clinic, Faculty of Medicine, Khon Kaen University, Thailand between January 2001 to December 2014. Significant lesions included cervical intraepithelial neoplasia grade 2-3, adenocarcinoma in situ, endometrial hyperplasia, and cancer...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/26830992/expression-of-potassium-channels-in-uterine-smooth-muscle-cells-from-patients-with-adenomyosis
#17
Jing-Hua Shi, Li Jin, Jin-Hua Leng, Jing-He Lang
BACKGROUND: Adenomyosis (AM) has impaired contraction. This study aimed to explore the expression of potassium channels related to contraction in myometrial smooth muscle cells (MSMCs) of AM. METHODS: Uterine tissue samples from 22 patients (cases) with histologically confirmed AM and 12 (controls) with cervical intraepithelial neoplasia were collected for both immunohistochemistry and real-time polymerase chain reaction to detect the expression of large conductance calcium- and voltage-sensitive K + channel (BKCa)-α/β subunits, voltage-gated potassium channel (Kv) 4...
January 20, 2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/26807560/loss-of-mismatch-repair-protein-expression-in-unselected-endometrial-adenocarcinoma-precursor-lesions
#18
Koah Robin Vierkoetter, Laura A T Kagami, Hyeong Jun Ahn, David M Shimizu, Keith Y Terada
OBJECTIVE: The benefit of evaluating the precursor of endometrial carcinoma, endometrial hyperplasia (intraepithelial neoplasia [EIN]), for loss of mismatch repair (MMR) protein expression and Lynch syndrome has yet to be determined. The present study aims to establish the incidence and type of loss of MMR protein expression in unselected premalignant lesions of endometrial adenocarcinoma, as well as the agreement of immunohistochemical staining in pretreatment endometrial biopsy (EMB) specimens with subsequent uterine resections...
February 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/26514516/is-age-an-independent-predictor-of-high-grade-histopathology-in-women-referred-for-colposcopy-after-abnormal-cervical-cytology
#19
Chalita Kingnate, Amornrat Supoken, Pilaiwan Kleebkaow, Bundit Chumworathayi, Sanguanchoke Luanratanakorn, Chumnan Kietpeerakool
This study was conducted to determine whether advancing age is an independent predictor of increased risk of high-grade pathologies among women referred for colposcopy after abnormal cervical cytology. Medical records were reviewed for women with abnormal cervical cytology who underwent colposcopy at Khon Kaen University Hospital. Logistic regression was used to determine the independent impact of age on the risk of high-grade pathologies. Mean age of the women was 42.8 years. Of 482 women, 97 (20.1%) were postmenopausal, and 92 (19...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/26456964/the-role-of-frozen-section-in-the-surgical-management-of-patients-with-endometrial-intraepithelial-neoplasia
#20
Mehmet Coşkun Salman, Derman Başaran, Alp Usubütün, Nejat Özgül, Kunter Yüce
OBJECTIVE: Patients with endometrial intraepithelial neoplasia may have concurrent endometrial cancer if managed surgically or develop cancer in time if managed conservatively. Therefore, intraoperative assessment of the uterus may be helpful if a surgical approach is decided on. Our study aimed to investigate the role of frozen-section examination in patients with endometrial intraepithelial neoplasia. MATERIAL AND METHOD: Patients with endometrial intraepithelial neoplasia who were subjected to hysterectomy with intraoperative frozen-section assessment were included...
2015: Türk Patoloji Dergisi
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