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endometrial cancer

Fenfen Wang, Qin Chen, Genping Huang, Xuedong Guo, Na Li, Yang Li, Baohua Li
BACKGROUND: The large-conductance, voltage-gated, calcium (Ca (2+))-activated potassium channel (BKCa) plays an important role in regulating Ca (2+) signaling and cell physiological function, and is aberrantly expressed in some types of cancers. The present study focuses on identifying the oncogenic potential and clinical significance of BKCa in endometrial adenocarcinoma, as well as exploring the mechanistic relevance by 17β -estradiol (E2) inducing aberrant activation of MEK1/2 and ERK1/2 via BKCa...
November 16, 2018: BMC Cancer
Jing Zuo, Ling Ying Wu, Min Cheng, Ping Bai, Cheng Zhi Lei, Ning Li, Gong Yi Zhang, Dan Zhao, Bin Li
STUDY OBJECTIVE: To evaluate the detection rate and accuracy of sentinel lymph node (SLN) mapping using cervical and fundal injection of carbon nanoparticles (CNPs) in laparoscopic surgery of endometrioid endometrial cancer (EC), and to identify uterine lymphatic drainage pathways validated by mapping. DESIGN: A prospective consecutive study (Canadian Task Force classification II-2) SETTING: A academic research center. PATIENTS: Consecutive patients with a pathological diagnosis of early-stage EC scheduled for primary laparoscopic-assisted staging surgery (laparoscopic hysterectomy, bilateral salpingo-oophorectomy, comprehensive lymphadenectomy)...
November 13, 2018: Journal of Minimally Invasive Gynecology
Konstantinos I Avgerinos, Nikolaos Spyrou, Christos S Mantzoros, Maria Dalamaga
Continuously rising trends in obesity-related malignancies render this disease spectrum a public health priority. Worldwide, the burden of cancer attributable to obesity, expressed as population attributable fraction, is 11.9% in men and 13.1% in women. There is convincing evidence that excess body weight is associated with an increased risk for cancer of at least 13 anatomic sites, including endometrial, esophageal, renal and pancreatic adenocarcinomas; hepatocellular carcinoma; gastric cardia cancer; meningioma; multiple myeloma; colorectal, postmenopausal breast, ovarian, gallbladder and thyroid cancers...
November 13, 2018: Metabolism: Clinical and Experimental
Shuqi Chi, Yan Liu, Xing Zhou, Dilu Feng, Xianjin Xiao, Wenliang Li, Yingchao Zhao, Hongbo Wang
PURPOSE: Progesterone, particularly medroxyprogesterone acetate (MPA) has been mainly used for young endometrial carcinoma (EC) patients with conservative treatment. However, its treatment benefits are limited by insensitivity or acquired resistance. In this study, we aim to investigate the effect of long non-coding RNA HOTAIR on progesterone sensitivity in endometrial cancer, as well as the underlying mechanisms. METHODS: The expression of HOTAIR was detected by quantitative real-time PCR...
November 15, 2018: Cancer Chemotherapy and Pharmacology
Xinyu Wu, Olivia Snir, Douglas Rottmann, Serena Wong, Natalia Buza, Pei Hui
Mismatch-repair deficiency testing plays a critical role in the identification of proband in Lynch Syndrome families and triaging patients with high stage or recurrent solid malignancies for check point inhibitor (Pembrolizumab) immunotherapy. We compared microsatellite shift patterns of microsatellite instability PCR analysis at 5 NCI recommended loci between microsatellite instability high endometrial carcinoma (n = 50) and microsatellite instability high colorectal cancer (n = 19). The endometrial cancer cohort included 45 endometrioid, 1 serous, and 4 clear cell carcinomas...
November 15, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Frederik Holst, Henrica M J Werner, Siv Mjøs, Erling A Hoivik, Kanthida Kusonmano, Elisabeth Wik, Anna Berg, Even Birkeland, William J Gibson, Mari K Halle, Jone Trovik, Andrew D Cherniack, Karl-Henning Kalland, Gordon B Mills, Christian F Singer, Camilla Krakstad, Rameen Beroukhim, Helga B Salvesen
Purpose: Amplification of PIK3CA , encoding the PI3K catalytic subunit alpha, is common in uterine corpus endometrial carcinoma (UCEC) and linked to an aggressive phenotype. However, it is unclear whether PIK3CA amplification acts via PI3K activation. We investigated the association between PIK3CA amplification, markers of PI3K activity, and prognosis in a large cohort of UCEC specimens. Experimental Design: UCECs from 591 clinically annotated patients including 83 tumors with matching metastasis ( n = 188) were analyzed by FISH to determine PIK3CA copy-number status...
November 15, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Martin Dušek, Ladislav Hadravský, Jan Stehlík, Kateřina Černá, Radmila Čurčíková, Marián Švajdler, Bohuslava Šašková, Magdaléna Dubová, Michal Michal, Tomáš Jirásek, Ondřej Daum
The introduction of a screening system for Lynch syndrome in pathology laboratories in Plzen yielded 24 diagnoses of Lynch syndrome during the period of 2013-2016, 20 of them presenting with colorectal cancer. In 8 of those 24 cases germline mutations of MMR genes, previously not recognized as pathogenic with certainty, were detected. Although the frequency of Lynch syndrome in patients with colorectal cancer was only 0.34 % in total, following introduction of the universal immunohistochemical investigation of MMR (mismatch repair) proteins expression in all colorectal cancers examined in Sikl´s Institute of Pathology the frequency per year in this department reached 2...
2018: Ceskoslovenská Patologie
Lichao Zhu, Xiaoyan Wang, Tao Wang, Wenwen Zhu, Xinge Zhou
MicroRNAs (miRs) are essential regulators in the development and progression of cancer. The role of miR-494-3p in endometrial cancer (EC) has not yet been investigated. In the present study, the expression levels of miR‑494‑3p were significantly upregulated in EC tissues compared with adjacent normal tissues. Furthermore, upregulation of miR‑494‑3p in patients with EC indicated poorer prognosis; miR‑494‑3p overexpression significantly promoted the proliferation, migration and invasion of HHUA and JEC cells in vitro...
November 13, 2018: Molecular Medicine Reports
Chunhua Zhang, Bo Wang, Ling Wu
MicroRNAs (miRNAs) are frequently dysregulated in human cancer and can act as either potent oncogenes or tumor suppressor genes. The aberrant expression of miRNA‑409 (miR‑409) has been found in certain types of cancer, however, its expression and potential biological role in endometrial cancer remain to be fully elucidated. In the present study, a total of 16 pairs of tissue samples from 16 patients with endometrial cancer were used in the present study, each of which consisted of human endometrial cancer tissue and matched adjacent normal tissue from the same patient...
November 12, 2018: Molecular Medicine Reports
Luiz Gustavo de Almeida Chuffa, Fábio Rodrigues Ferreira Seiva, Maira Smaniotto Cucielo, Henrique Spaulonci Silveira, Russel J Reiter, Luiz Antonio Lupi
Cancers of the reproductive organs have a strong association with mitochondrial defects, and a deeper understanding of the role of this organelle in preneoplastic-neoplastic changes is important to determine the appropriate therapeutic intervention. Mitochondria are involved in events during cancer development, including metabolic and oxidative status, acquisition of metastatic potential, resistance to chemotherapy, apoptosis, and others. Because of their origin from melatonin-producing bacteria, mitochondria are speculated to produce melatonin and its derivatives at high levels; in addition, exogenously administered melatonin accumulates in the mitochondria against a concentration gradient...
November 14, 2018: Cellular and Molecular Life Sciences: CMLS
Pei-Li Wu, Cheng Zeng, Ying-Fang Zhou, Ling Yin, Xiao-Lan Yu, Qing Xue
Endometriosis is an estrogen-dependent disease. Farnesoid X receptor (FXR) activation has been shown to inhibit estrogen signaling in breast cancer and testicular tumors. However, the role of FXR in endometriosis is still poorly understood. Here, we aimed to investigate whether FXR activation by its synthetic agonist GW4064 has a therapeutic effect on endometriosis and the underlying molecular mechanisms. We found that the expression of FXR (encoded by the NR1H4 gene) in endometriotic tissues and stromal cells (ESCs) was higher than that in eutopic endometrial tissues and stromal cells...
November 14, 2018: Reproductive Sciences
Shinichi Togami, Toshihiko Kawamura, Mika Fukuda, Shintaro Yanazume, Masaki Kamio, Hiroaki Kobayashi
OBJECTIVE: The detection accuracy of sentinel lymph node (SLN) metastasis by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) for endometrial cancer (EC) remains unclear and was assessed in this preliminary study. METHODS: We studied primary cancer tissues and pelvic lymph nodes (PLN) from 105 patients with EC. qRT-PCR assay was performed to determine the copy numbers of CK19 mRNA in EC tissues, and negative and positive LN samples. Further, qRT-PCR results were compared with pathological findings...
November 14, 2018: Oncology
Chunfang Wang, Ke Su, Yanyan Zhang, Weiwei Zhang, Qian Zhao, Danxia Chu, Ruixia Guo
BACKGROUND: Obesity is a risk factor for endometrial cancer (EC). However, it is not known how insulin receptor isoform A (IR-A) and insulin-like growth factor 1 receptor (IGF-1R), cognate receptors for insulin and IGFs, respectively, regulate malignant behaviors of EC. In this study, we examined the biological effects of IR-A/IGF-1R, explored the downstream signaling cascades, and assessed the therapeutic potential of targeting IR-A/IGF-1R in vivo. METHODS: The expression levels of IR-A and IGF-1R were examined by qRT-PCR and Western blotting...
November 14, 2018: Cancer Biology & Therapy
Satoru Nagase, Tsuyoshi Ohta, Fumiaki Takahashi, Takayuki Enomoto
AIM: To provide information including the trend of gynecological malignancies in Japan, we hereby present the Annual Patient Report for 2015 and the Annual Treatment Report for 2010 on the outcomes of patients who started treatment in 2010. METHODS: The Japan Society of Obstetrics and Gynecology maintains an annual tumor registry where information on gynecological malignancies from various participating institutions is gathered. The data of patients whose treatment was initiated in 2015 were analyzed retrospectively...
November 13, 2018: Journal of Obstetrics and Gynaecology Research
Michelle L MacKintosh, Emma J Crosbie
PURPOSE OF THE REVIEW: To assess the most recent high-quality evidence for endometrial cancer prevention strategies. RECENT FINDINGS: Obesity is an established risk factor for endometrial cancer. Weight cycling and weight gain in middle age are risk factors for endometrial cancer. Bariatric surgery reduces the risk of endometrial cancer by up to 81% in obese women who attain and maintain a normal weight. Combined oral contraceptives provide durable protection against endometrial cancer for 30 years or more...
November 13, 2018: Current Oncology Reports
Eric J Devor, Elizabeth Cha, Akshaya Warrier, Marina D Miller, Jesus Gonzalez-Bosquet, Kimberly K Leslie
Background: The miR-503 miRNA cluster, located at Xq23.1, is composed of six miRNAs; miR-424, miR-503, miR-542, miR-450a-1, miR-450a-2 and miR-450b. Numerous studies have focused on the relationship of one or two members of the cluster and various human cancers. Here, we suggest that the entire cluster as a single coordinately expressed polycistron transcribed from a single promoter in endometrial endometrioid adenocarcinoma (EEA). Subjects and methods: A tissue panel composed of twenty histologically confirmed endometrial endometrioid adenocarcinomas (EEA) and four benign endometrium was assembled under informed consent...
2018: OncoTargets and Therapy
Chanil Deshan Ekanayake, Ramani Punchihewa, Prasantha Sudehana Wijesinghe
BACKGROUND: Ovarian lymphoma has a varied clinical presentation and rarely presents with heavy menstrual bleeding. It may occur de novo or secondary to systemic disease and macroscopically appear as solid ovarian tumors. CASE PRESENTATION: A 32-year-old Tamil woman presented with heavy menstrual bleeding of 4 months' duration. On examination she was anemic with no lymphadenopathy. A large immobile pelvic mass and three firm nodules were found involving her vaginal walls...
November 14, 2018: Journal of Medical Case Reports
Sabine Schuster, Beáta Biri-Kovács, Bálint Szeder, László Buday, János Gardi, Zsuzsanna Szabó, Gábor Halmos, Gábor Mező
Receptors for gonadotropin releasing hormone (GnRH) are highly expressed in various human cancers including breast, ovarian, endometrial, prostate and colorectal cancer. Ligands like human GnRH-I or the sea lamprey analogue GnRH-III represent a promising approach for the development of efficient drug delivery systems for targeted tumor therapy. Here, we report on the synthesis and cytostatic effect of 14 oxime bond-linked daunorubicin GnRH-III conjugates containing a variety of unnatural amino acids within the peptide sequence...
November 9, 2018: Pharmaceutics
Takashi Mitamura, Peixin Dong, Kei Ihira, Masataka Kudo, Hidemichi Watari
The overall survival rate of patients with early-stage endometrial cancer is relatively high; however, there are few treatment options for patients with advanced or recurrent endometrial cancer, and the prognosis of such patients remains poor. Recent progress in molecular-targeted therapies demonstrated that they have the potential to improve the long-term survival of cancer patients with appropriate biomarkers. However, the median progression-free survival of patients who received single-agent molecular-targeted therapy was <5 months, and the development of molecular-targeted therapies for endometrial cancer patients is urgently needed...
November 13, 2018: Japanese Journal of Clinical Oncology
Mustafa Erkan Sarı, Mehmet Mutlu Meydanlı, Ibrahim Yalçın, Hanifi Şahin, Gonca Çoban, Hüsnü Çelik, Esra Kuşçu, Tayfun Gungor, Ali Ayhan
INTRODUCTION: We aimed to assess risk factors for lymph node (LN) metastasis among lymphovascular space invasion(LVSI)-positive women with pure endometrioid endometrial cancer (EC) clinically confined to the uterus. METHODS: Medical records of women who underwent primary surgery for EC between 2007 and 2016 at either of 2 gynecological oncology centers were retrospectively reviewed. Patient data were analyzed with respect to LN involvement, and predictive factors for LN metastasis were investigated...
November 13, 2018: Oncology Research and Treatment
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