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endometrial cancer

H-M Guo, S-H Yang, S-Z Zhao, L Li, M-T Yan, M-C Fan
OBJECTIVE: Cervical cancer is a common tumor in gynecological malignancies. Recent studies showed that long non-coding RNAs (lncRNAs) play a key role in tumorigenesis and development. LncRNA nuclear-rich transcripts 1 (NEAT1) has been found to play a role in gynecological tumors, such as endometrial cancer. However, expression of lncRNA NEAT1 and mechanism in cervical cancer has not been elucidated. MATERIALS AND METHODS: The tumor tissue and adjacent tissue of cervical cancer patients were collected...
July 2018: European Review for Medical and Pharmacological Sciences
Chang Liu, Ying Li, Shasha Hu, Yao Chen, Li Gao, Dajiang Liu, Hongtao Guo, Yongxiu Yang
BACKGROUND: Matrix metalloproteinase-2 (MMP-2), a member of the zinc-dependent metalloproteinase gene family, plays a vital role in cancer invasion, metastasis, and progression. This systematic review and meta-analysis aims to explore the clinical significance of MMP-2 expression in endometrial cancer. METHODS: PubMed, Embase, Cochrane Library, and China National Knowledge Infrastructure databases were systematically searched up to September 30, 2017, supplemented by manual searches of bibliographies...
July 2018: Medicine (Baltimore)
Gustavo Filipov Peres, Daniel Spadoto-Dias, Flávia Neves Bueloni-Dias, Nilton José Leite, Leonardo Vieira Elias, Maria Aparecida Custódio Domingues, Carlos Roberto Padovani, Rogério Dias
Objective: The aim of this study was to investigate the malignant potential of endometrial polyps (EP) by assessing the immunoexpressions of both estrogen receptor (ER) and progesterone receptor (PR), Ki-67 cell proliferation index, neovascularization network (endoglin - CD105), cellular adhesion molecules (claudins 3 and 4), and extracellular matrix proteins (MMP-2 and -9) in both EP and endometrioid adenocarcinoma (type I) in comparison with the normal endometrium. Study design: This is a cross-sectional comparative study...
2018: OncoTargets and Therapy
Hung Chun Fu, Jen Ruei Chen, Min Yu Chen, Keng Fu Hsu, Wen Fang Cheng, An Jen Chiang, Yu Min Ke, Yu Chieh Chen, Yin Yi Chang, Chia Yen Huang, Chieh Yi Kang, Yuan Yee Kan, Sheng Mou Hsiao, Ming Shyen Yen
OBJECTIVE: Choice of hysterectomy and adjuvant treatment for International Federation of Gynecology and Obstetrics (FIGO) 2009 stage II endometrioid endometrial cancer (EEC) is still controversial. Aims of this study were to evaluate survival benefits and adverse effects of different hysterectomies with or without adjuvant radiotherapy (RT), and to identify prognostic factors. METHODS: The patients at 14 member hospitals of the Taiwanese Gynecologic Oncology Group from 1992 to 2013 were retrospectively investigated...
May 15, 2018: Journal of Gynecologic Oncology
Soyi Lim, Yun Hwan Kim, Kwang Beom Lee, Jong Min Lee
OBJECTIVE: To determine whether drospirenone/estradiol (DRSP/E2) has an adverse effect on clinical outcomes in surgically staged International Federation of Gynecology and Obstetrics (FIGO) stage I/II endometrial cancer (EC) patients. METHODS: In a retrospective case-controlled study, 58 women with EC who had received DRSP/E2 postoperatively were compared with 116 women who had not. And, oncologic safety of postoperative hormone therapy with DRSP/E2 in EC survivors were compared between the 2 groups after propensity score matching using a logistic regression model...
May 4, 2018: Journal of Gynecologic Oncology
Koji Matsuo, Hiroko Machida, Andrea Mariani, Rachel S Mandelbaum, Gretchen E Glaser, Bobbie S Gostout, Lynda D Roman, Jason D Wright
OBJECTIVE: To examine the trends and survival for women with early-stage epithelial ovarian cancer who underwent adequate lymphadenectomy during surgical treatment. METHODS: This is a retrospective observational study examining the Surveillance, Epidemiology, End Results program between 1988 and 2013. We evaluated 21,537 cases of stage I-II epithelial ovarian cancer including serous (n=7,466), clear cell (n=6,903), mucinous (n=4,066), and endometrioid (n=3,102) histology...
May 4, 2018: Journal of Gynecologic Oncology
Takahiro Yaguchi
Endocrine disruptors have become a global social and public health problem since the late 1980s. Bisphenol A (BPA) has a steroid-like skeleton similar to estrogen and progesterone, and is an endocrine disruptor that disturbs the physiological hormone balance. The potential involvement of BPA in malignancy of endometrial cancer cells caused by overexposure of steroid hormones remains incompletely understood. The present study aimed at understanding the regulatory mechanism underlying BPA-induced cell proliferation in hormone-sensitive endometrial cancer cells...
July 18, 2018: Molecular and Cellular Biochemistry
Luyao Zhang, Hongyao Yu, Otto Hemminki, Asta Försti, Kristina Sundquist, Kari Hemminki
Familial risks for testicular cancer (TC) are among the highest of all cancers. However, data are limited for histological types of TC and for possible familial associations of TC with other cancers. We used the nationwide Swedish Family-Cancer Database for years 1958 to 2015 to analyse familial relative risks (RR) for 11,138 TC patients when first-degree relatives were diagnosed with TC or other cancer in reference to those without a family history. A total of 191 familial TCs were found, which accounted for 2...
July 18, 2018: Scientific Reports
Hanzi Xu, Zhen Gong, Siying Zhou, Sujin Yang, Dandan Wang, Xiu Chen, Jiaqi Wu, Liucheng Liu, Shanliang Zhong, Jianhua Zhao, Jinhai Tang
BACKGROUND/AIMS: Emerging evidence suggests that curcumin possesses chemopreventive properties against various cancers. However, its poor bioavailability limits its clinical application. In this study, we aimed to utilize encapsulation in liposomes (Lipo) as a strategy for the clinical administration of curcumin for endometrial carcinoma (EC). METHODS: Curcumin was encapsulated in a liposomal delivery system to prepare a formulation of liposomal curcumin (LC). EC cell lines Ishikawa and HEC-1 were treated with the compound and cell proliferation was measured using MTT assay...
July 18, 2018: Cellular Physiology and Biochemistry
Alice H Hsu, Michelle A Lum, Kang-Sup Shim, Peter J Frederick, Carl D Morrison, Baojiang Chen, Subodh M Lele, Yuri M Sheinin, Takiko Daikoku, Sudhansu K Dey, Gustavo Leone, Adrian R Black, Jennifer D Black
Protein kinase C (PKC) isozymes are commonly recognized as oncoproteins based on their activation by tumor-promoting phorbol esters. However, accumulating evidence indicates that PKCs can be inhibitory in some cancers, with recent findings propelling a shift in focus to understanding tumor suppressive functions of these enzymes. Here, we report that PKCα acts as a tumor suppressor in PI3K/AKT-driven endometrial cancer. Transcriptional suppression of PKCα is observed in human endometrial tumors in association with aggressive disease and poor prognosis...
July 17, 2018: Cell Reports
Sakthivignesh Ponandai-Srinivasan, Karin L Andersson, Monica Nister, Merli Saare, Halima A Hassan, Suby J Varghese, Maire Peters, Andres Salumets, Kristina Gemzell-Danielsson, Parameswaran Grace Luther Lalitkumar
STUDY QUESTION: Is there molecular evidence for a link between endometriosis and endometriosis-associated ovarian cancers (EAOC)? STUDY ANSWER: We identified aberrant gene expression signatures associated with malignant transformation in a small subgroup of women with ovarian endometriosis. WHAT IS KNOWN ALREADY: Epidemiological studies have shown an increased risk of EAOC in women with ovarian endometriosis. However, the cellular and molecular changes leading to EAOC are largely unexplored...
July 18, 2018: Human Reproduction
Qianjin Fang, Lin Sang, Shihua Du
Long noncoding RNA LINC00261 was reported to be downregulated in multiple cancers. LINC00261 overexpression inhibits cancer cell proliferation, migration, and invasion. But the expression and function of LIN00261 in endometrial carcinoma are still elusive. We found that LINC00261 mRNA levels were downregulated in endometrial carcinoma, and LINC00261 overexpression inhibited endometrial carcinoma cell proliferation, migration, and invasion. miRNAs, including miR-182, miR-183, miR-153, miR-27a, and miR-96, were predicted to bind LINC00261 and FOXO1, and functioned to attenuate expression of LINC00261 and FOXO1...
July 18, 2018: Cell Biochemistry and Function
John Michael O Ranola, Rachel Pearlman, Heather Hampel, Brian H Shirts
Past methods for estimating the population frequency of familial cancer syndromes have used cases and controls ignoring the familial nature of genetic disease. In this study we modified the capture-recapture method from ecology to estimate the number of families in central Ohio with Lynch syndrome (LS). We screened 1566 colorectal cancer cases and 545 endometrial cancer cases in central Ohio from 1999 to 2005 and identified 58 with LS. We screened an additional 3346 colorectal and 342 endometrial cancer cases from 2013 to 2016 and identified 149 with LS...
July 17, 2018: Familial Cancer
Clara Musicco, Gennaro Cormio, Vito Pesce, Vera Loizzi, Ettore Cicinelli, Leonardo Resta, Girolamo Ranieri, Antonella Cormio
Type I endometrial cancer (EC) is the most common form of EC, displaying less aggressive behavior than type II. The development of type I endometrial cancer is considered a multistep process, with slow progression from normal endometrium to hyperplasia, the premalignant form, and endometrial cancer as a result of an unopposed estrogenic stimulation. The role of mitochondria in type I EC tumor progression and prognosis is currently emerging. This review aims to explore mitochondrial alterations in this cancer and in endometrial hyperplasia focusing on mitochondrial DNA mutations, respiratory complex I deficiency, and the activation of mitochondrial quality control systems...
July 17, 2018: International Journal of Molecular Sciences
Pierluigi Giampaolino, Attilio Di Spiezio Sardo, Antonio Mollo, Antonio Raffone, Antonio Travaglino, Antonio Boccellino, Brunella Zizolfi, Luigi Insabato, Fulvio Zullo, Giuseppe De Placido, Giuseppe Bifulco
STUDY OBJECTIVE: To evaluate safety and effectiveness of the combination of hysteroscopic endometrial focal resection with levonorgestrel-releasing intrauterine device (LNG-IUD) for FIGO IA G1 early endometrial cancer (EEC) and atypical endometrial hyperplasia (AEH) in young women to preserve their fertility. DESIGN (CANADIAN TASK FORCE CLASSIFICATION): Retrospective case series (Level II-3). SETTING: University Federico II, Naples, Italy...
July 11, 2018: Journal of Minimally Invasive Gynecology
Francesca Menghi, Floris P Barthel, Vinod Yadav, Ming Tang, Bo Ji, Zhonghui Tang, Gregory W Carter, Yijun Ruan, Ralph Scully, Roel G W Verhaak, Jos Jonkers, Edison T Liu
The tandem duplicator phenotype (TDP) is a genome-wide instability configuration primarily observed in breast, ovarian, and endometrial carcinomas. Here, we stratify TDP tumors by classifying their tandem duplications (TDs) into three span intervals, with modal values of 11 kb, 231 kb, and 1.7 Mb, respectively. TDPs with ∼11 kb TDs feature loss of TP53 and BRCA1. TDPs with ∼231 kb and ∼1.7 Mb TDs associate with CCNE1 pathway activation and CDK12 disruptions, respectively. We demonstrate that p53 and BRCA1 conjoint abrogation drives TDP induction by generating short-span TDP mammary tumors in genetically modified mice lacking them...
June 29, 2018: Cancer Cell
João Lopes, Mariana Horta, Teresa Margarida Cunha
Clinical and pathological aspects of endometrial cancers that develop after radiation therapy for cervical carcinoma have been studied for years but their imaging features have not yet been described. To determine these features, we performed a retrospective study that included all patients of our institution that were diagnosed with an endometrial cancer after being submitted to radiation therapy for cervical cancer and that performed computed tomography (CT) or magnetic resonance (MR) imaging at the time of the diagnosis, in a period of 11 years...
August 2018: European Journal of Radiology
Vivian Lac, David G Huntsman
Endometriosis is a common gynecologic disease characterized by the ectopic growth of endometrial-like tissue. Despite the widespread prevalence of endometriosis, its pathogenesis remains poorly understood. A recent study by Noë et al. provides evidence that the epithelium and stroma within the same endometriotic lesions follow distinct and independent developmental trajectories. They used droplet digital PCR analysis of laser-captured epithelial-enriched and stromal-enriched endometriosis tissue and found that all 19 somatic passenger mutations analyzed were enriched exclusively in the epithelial compartment...
July 17, 2018: Journal of Pathology
Anna Myriam Perrone, Giulia Girolimetti, Martina Procaccini, Lorena Marchio, Alessandra Livi, Giulia Borghese, Anna Maria Porcelli, Pierandrea De Iaco, Giuseppe Gasparre
In the event of multiple synchronous gynecological lesions, a fundamental piece of information to determine patient management, prognosis, and therapeutic regimen choice is whether the simultaneous malignancies arise independently or as a result of metastatic dissemination. An example of synchronous primary tumors of the female genital tract most frequently described are ovarian and endometrial cancers. Surgical findings and histopathological examination aimed at resolving this conundrum may be aided by molecular analyses, although they are too often inconclusive...
July 13, 2018: International Journal of Molecular Sciences
Boyeon Kim, Yongjung Park, Banseok Kim, Hyo Jun Ahn, Kyung-A Lee, Jae Eun Chung, Sang Won Han
OBJECTIVE: We evaluated the diagnostic performance of CA 125, HE4, and ROMA for ovarian cancer in Koreans and set optimal cutoffs. METHOD: Serum levels of HE4 and CA 125 and the ROMA score were determined in 762 patients with benign gynecological disease and 70 with ovarian cancer. Receiver operating characteristic curves were constructed to calculate the areas under the curve (AUC). CA 125, HE4, and ROMA exhibiting maximum Youden index were determined, respectively, as the optimal cutoffs, and sensitivity and specificity were evaluated by applying those cutoffs...
July 15, 2018: Journal of Clinical Laboratory Analysis
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